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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:carbon disulfide
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Accession:CHEBI:23012 term browser browse the term
Definition:An organosulfur compound that has formula CS2.
Synonyms:exact_synonym: disulfidocarbon
 related_synonym: CS2;   Formula=CS2;   InChI=1S/CS2/c2-1-3;   InChIKey=QGJOPFRUJISHPQ-UHFFFAOYSA-N;   SMILES=S=C=S;   carbon disulphide
 xref: CAS:75-15-0;   KEGG:C19033
 xref_mesh: MESH:D002246
 xref: PPDB:2724;   UM-BBD_compID:c0561


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carbon disulfide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actb actin, beta increases expression EXP Carbon Disulfide results in increased expression of ACTB mRNA; Carbon Disulfide results in increased expression of ACTB protein CTD PMID:16474999 PMID:17498345 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877 		JBrowse link
G Atg5 autophagy related 5 multiple interactions
decreases expression		 ISO N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of ATG5 mRNA]
Carbon Disulfide results in decreased expression of ATG5 mRNA; Carbon Disulfide results in decreased expression of ATG5 protein		 CTD PMID:31369747 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Carbon Disulfide results in increased expression of BAX mRNA; Carbon Disulfide results in increased expression of BAX protein CTD PMID:24080331 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Carbon Disulfide results in decreased expression of BCL2 mRNA; Carbon Disulfide results in decreased expression of BCL2 protein CTD PMID:24080331 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Becn1 beclin 1 decreases expression
multiple interactions		 ISO Carbon Disulfide results in decreased expression of BECN1 mRNA; Carbon Disulfide results in decreased expression of BECN1 protein
N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of BECN1 mRNA]; N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of BECN1 protein]		 CTD PMID:31369747 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 increases expression EXP Carbon Disulfide results in increased expression of CAMKK2 protein CTD PMID:27530093 NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279 		JBrowse link
G Capn1 calpain 1 increases expression EXP Carbon Disulfide results in increased expression of CAPN1 protein CTD PMID:17120161 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177 		JBrowse link
G Capn2 calpain 2 decreases expression
increases expression		 EXP Carbon Disulfide results in decreased expression of CAPN2 protein
Carbon Disulfide results in increased expression of CAPN2 protein		 CTD PMID:17120161 PMID:19165470 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969 		JBrowse link
G Casp3 caspase 3 increases expression ISO Carbon Disulfide results in increased expression of CASP3 mRNA; Carbon Disulfide results in increased expression of CASP3 protein CTD PMID:24080331 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase decreases activity EXP Carbon Disulfide results in decreased activity of CAT protein CTD PMID:19070609 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ctsb cathepsin B increases expression ISO Carbon Disulfide results in increased expression of CTSB protein CTD PMID:24887698 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Faslg Fas ligand increases expression EXP Carbon Disulfide results in increased expression of FASLG mRNA CTD PMID:17241545 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression EXP Carbon Disulfide results in increased expression of GCLC mRNA CTD PMID:27530093 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 affects metabolic processing ISO GSTM1 gene polymorphism affects the metabolism of Carbon Disulfide CTD PMID:17333241 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 affects metabolic processing ISO GSTT1 gene polymorphism affects the metabolism of Carbon Disulfide CTD PMID:17333241 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Carbon Disulfide results in increased expression of HMOX1 mRNA CTD PMID:27530093 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il12b interleukin 12B increases expression ISO Carbon Disulfide results in increased expression of IL12B mRNA CTD PMID:31468960 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il6 interleukin 6 increases expression ISO Carbon Disulfide results in increased expression of IL6 mRNA; Carbon Disulfide results in increased expression of IL6 protein CTD PMID:31468960 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgb3 integrin subunit beta 3 decreases expression ISO Carbon Disulfide results in decreased expression of ITGB3 mRNA; Carbon Disulfide results in decreased expression of ITGB3 protein CTD PMID:24025711 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression EXP Carbon Disulfide results in decreased expression of KEAP1 protein CTD PMID:27530093 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 increases expression ISO Carbon Disulfide results in increased expression of LAMP1 protein CTD PMID:24887698 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta decreases expression
multiple interactions		 ISO Carbon Disulfide results in decreased expression of MAP1LC3B mRNA; Carbon Disulfide results in decreased expression of MAP1LC3B protein
N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of MAP1LC3B mRNA]; N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in decreased expression of MAP1LC3B protein]		 CTD PMID:31369747 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Mtor mechanistic target of rapamycin kinase affects phosphorylation
decreases expression
multiple interactions		 EXP
ISO		 Carbon Disulfide affects the phosphorylation of MTOR protein
Carbon Disulfide results in decreased expression of MTOR mRNA; Carbon Disulfide results in decreased expression of MTOR protein; Carbon Disulfide results in decreased expression of MTOR protein modified form
Carbamoyl Phosphate Synthetase I Activators inhibits the reaction [Carbon Disulfide results in decreased expression of MTOR protein]		 CTD PMID:27530093 PMID:30521784 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nefh neurofilament heavy chain decreases expression
increases expression		 EXP Carbon Disulfide results in decreased expression of NEFH protein
Carbon Disulfide results in increased expression of NEFH mRNA		 CTD PMID:16474999 PMID:17120161 PMID:19165470 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351 		JBrowse link
G Nefl neurofilament light chain decreases expression
increases expression		 EXP Carbon Disulfide results in decreased expression of NEFL protein
Carbon Disulfide results in increased expression of NEFL mRNA; Carbon Disulfide results in increased expression of NEFL protein		 CTD PMID:16474999 PMID:17120161 PMID:19165470 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793 		JBrowse link
G Nefm neurofilament medium chain decreases expression
increases expression		 EXP Carbon Disulfide results in decreased expression of NEFM protein
Carbon Disulfide results in increased expression of NEFM mRNA; Carbon Disulfide results in increased expression of NEFM protein		 CTD PMID:16474999 PMID:17120161 PMID:19165470 NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization EXP Carbon Disulfide affects the localization of NFE2L2 protein CTD PMID:27530093 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP Carbon Disulfide results in increased expression of NQO1 mRNA; Carbon Disulfide results in increased expression of NQO1 protein CTD PMID:27530093 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 affects phosphorylation EXP Carbon Disulfide affects the phosphorylation of RPS6KB1 protein CTD PMID:27530093 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 increases expression EXP Carbon Disulfide results in increased expression of RPTOR protein CTD PMID:27530093 NCBI chr10:104,878,487...105,176,986
Ensembl chr10:104,878,487...105,176,983 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression		 EXP
ISO		 Carbon Disulfide results in increased expression of and results in increased phosphorylation of SQSTM1 protein
Carbon Disulfide results in increased expression of SQSTM1 mRNA; Carbon Disulfide results in increased expression of SQSTM1 protein
N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in increased expression of SQSTM1 mRNA]; N-carbamylglutamate inhibits the reaction [Carbon Disulfide results in increased expression of SQSTM1 protein]		 CTD PMID:27530093 PMID:31369747 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO Carbon Disulfide results in decreased expression of TGFB1 mRNA CTD PMID:31468960 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 increases expression
increases phosphorylation		 ISO
EXP		 Carbon Disulfide results in increased expression of ULK1 protein
Carbon Disulfide results in increased phosphorylation of ULK1 protein		 CTD PMID:24887698 PMID:27530093 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966 		JBrowse link
G Uvrag UV radiation resistance associated increases expression ISO Carbon Disulfide results in increased expression of UVRAG protein CTD PMID:24887698 NCBI chr 1:153,185,356...153,442,200
Ensembl chr 1:153,185,395...153,442,136 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Carbon Disulfide results in decreased expression of VEGFA mRNA; Carbon Disulfide results in decreased expression of VEGFA protein CTD PMID:31468960 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    chemical entity 19878
      atom 19878
        nonmetal atom 19800
          sulfur atom 17752
            sulfur molecular entity 17752
              organosulfur compound 17450
                carbon disulfide 35
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            heteroorganic entity 19512
                              organochalcogen compound 19275
                                organosulfur compound 17450
                                  carbon disulfide 35
paths to the root