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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:selinexor
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Accession:CHEBI:229764 term browser browse the term
Definition:A member of the class of triazoles that is 1H-1,2,4-triazole substituted by (1Z)-3-oxo-3-[2-(pyrazin-2-yl)hydrazinyl]prop-1-en-1-yl and 3,5-bis(trifluoromethyl)phenyl groups at positions 1 and 3, respectively. It is a prescription medicine approved for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma.
Synonyms:related_synonym: (2Z)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1- yl}-N'-(pyrazin-2-yl)prop-2-enehydrazide;   Formula=C17H11F6N7O;   InChI=1S/C17H11F6N7O/c18-16(19,20)11-5-10(6-12(7-11)17(21,22)23)15-26-9-30(29-15)4-1-14(31)28-27-13-8-24-2-3-25-13/h1-9H,(H,25,27)(H,28,31)/b4-1-;   InChIKey=DEVSOMFAQLZNKR-RJRFIUFISA-N;   KPT 330;   SMILES=FC(F)(F)C1=CC(=CC(=C1)C1=NN(\\C=C/C(=O)NNC2=NC=CN=C2)C=N1)C(F)(F)F;   Xpovio;   selinexorum
 xref: DrugBank:DB11942;   HMDB:HMDB0258217;   KEGG:D11222
 xref_mesh: MESH:C585161
 xref: PMID:23373539;   PMID:27893412;   PMID:28314790;   PMID:28810913;   PMID:28852098;   PMID:29707241;   PMID:30064906;   PMID:30115935;   PMID:30996012;   PMID:32598257;   PMID:33403670;   PMID:33507295;   PMID:33601919;   PMID:34488662;   PMID:34669417;   PMID:34741230;   PMID:35355406;   PMID:35477814;   PMID:35667526;   PMID:35941226;   PMID:36180918;   PMID:36200270;   PMID:36622814;   PMID:36731340;   PMID:36827679;   PMID:36847599;   PMID:37016732;   PMID:37046649;   PMID:37047788;   PMID:37079389;   PMID:37094850;   PMID:37126200;   PMID:37175668;   PMID:37184196;   PMID:37191210;   PMID:37346402;   PMID:37595020;   PMID:37715291;   PMID:37760508;   PMID:37945593;   PMID:38105606;   PMID:38186637;   PMID:38454813;   Wikipedia:Selinexor


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selinexor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase multiple interactions ISO [selinexor co-treated with INCB057643] results in decreased phosphorylation of ATM protein CTD PMID:37899423 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629 		JBrowse link
G Atr ATR serine/threonine kinase multiple interactions ISO [selinexor co-treated with INCB057643] results in decreased phosphorylation of ATR protein CTD PMID:37899423 NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:105,306,305...105,403,718 		JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions
increases expression 		ISO [INCB057643 co-treated with selinexor] results in increased expression of BBC3 protein
selinexor results in increased expression of BBC3 protein 		CTD PMID:37899423 NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666 		JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions ISO [selinexor co-treated with INCB057643] results in decreased phosphorylation of CHEK1 protein CTD PMID:37899423 NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:44,609,417...44,629,359 		JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO [selinexor co-treated with INCB057643] results in decreased phosphorylation of CHEK2 protein CTD PMID:37899423 NCBI chr12:51,448,838...51,481,159
Ensembl chr12:51,449,140...51,480,667 		JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions 		ISO selinexor results in increased expression of H2AX protein
[selinexor co-treated with INCB057643] results in increased expression of H2AX protein 		CTD PMID:37899423 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression
multiple interactions 		ISO selinexor results in increased expression of MDM2 protein
[INCB057643 co-treated with selinexor] results in increased expression of MDM2 protein 		CTD PMID:37899423 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases expression 		ISO INCB057643 promotes the reaction [selinexor results in decreased expression of MYC mRNA]; INCB057643 promotes the reaction [selinexor results in decreased expression of MYC protein]; selinexor promotes the reaction [INCB057643 results in decreased expression of MYC mRNA]; selinexor promotes the reaction [INCB057643 results in decreased expression of MYC protein]
selinexor results in decreased expression of MYC mRNA; selinexor results in decreased expression of MYC protein 		CTD PMID:37899423 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions ISO [INCB057643 co-treated with selinexor] results in increased expression of PMAIP1 protein CTD PMID:37899423 NCBI chr18:62,255,970...62,262,384
Ensembl chr18:62,255,598...62,262,382 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions 		ISO selinexor results in increased expression of TP53 protein
[INCB057643 co-treated with selinexor] results in increased expression of TP53 protein 		CTD PMID:37899423 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Tp73 tumor protein p73 increases expression ISO selinexor results in increased expression of TP73 protein CTD PMID:37899423 NCBI chr 5:169,903,801...169,988,075
Ensembl chr 5:169,903,801...169,963,552 		JBrowse link
G Wee1 WEE1 G2 checkpoint kinase multiple interactions ISO [selinexor co-treated with INCB057643] results in decreased phosphorylation of WEE1 protein CTD PMID:37899423 NCBI chr 1:173,605,609...173,632,450
Ensembl chr 1:173,608,949...173,632,449 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20871
    role 20829
      application 20632
        anti-inflammatory agent 16830
          selinexor 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 20871
    subatomic particle 20869
      composite particle 20869
        hadron 20869
          baryon 20869
            nucleon 20869
              atomic nucleus 20869
                atom 20869
                  main group element atom 20792
                    p-block element atom 20792
                      carbon group element atom 20725
                        carbon atom 20721
                          organic molecular entity 20721
                            heteroorganic entity 20226
                              organochalcogen compound 19911
                                organooxygen compound 19814
                                  carbon oxoacid 19160
                                    carboxylic acid 19157
                                      carboacyl group 18080
                                        univalent carboacyl group 18080
                                          carbamoyl group 17916
                                            carboxamide 17916
                                              alpha,beta-unsaturated carboxylic acid amide 7293
                                                enamide 7293
                                                  selinexor 12
paths to the root