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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:exportin 1 inhibitor
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Accession:CHEBI:229763 term browser browse the term
Definition:Any inhibitor of exportin 1.
Synonyms:related_synonym: CRM-1 inhibitor;   CRM-1 inhibitors;   CRM1 inhibitor;   CRM1 inhibitors;   SINE compound;   SINE compounds;   SINEs;   XPO1 inhibitor;   XPO1 inhibitors;   chromosomal region maintenance 1 inhibitor;   chromosomal region maintenance 1 inhibitors;   exportin-1 inhibitors;   selective inhibitor of nuclear export;   selective inhibitors of nuclear export
 xref: PMID:37595020;   PMID:37899423;   PMID:38105606;   Wikipedia:XPO1


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selinexor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase multiple interactions ISO [selinexor co-treated with INCB057643] results in decreased phosphorylation of ATM protein CTD PMID:37899423 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Atr ATR serine/threonine kinase multiple interactions ISO [selinexor co-treated with INCB057643] results in decreased phosphorylation of ATR protein CTD PMID:37899423 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136 		JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions
increases expression		 ISO [INCB057643 co-treated with selinexor] results in increased expression of BBC3 protein
selinexor results in increased expression of BBC3 protein		 CTD PMID:37899423 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions ISO [selinexor co-treated with INCB057643] results in decreased phosphorylation of CHEK1 protein CTD PMID:37899423 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO [selinexor co-treated with INCB057643] results in decreased phosphorylation of CHEK2 protein CTD PMID:37899423 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions		 ISO selinexor results in increased expression of H2AX protein
[selinexor co-treated with INCB057643] results in increased expression of H2AX protein		 CTD PMID:37899423 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression
multiple interactions		 ISO selinexor results in increased expression of MDM2 protein
[INCB057643 co-treated with selinexor] results in increased expression of MDM2 protein		 CTD PMID:37899423 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases expression		 ISO INCB057643 promotes the reaction [selinexor results in decreased expression of MYC mRNA]; INCB057643 promotes the reaction [selinexor results in decreased expression of MYC protein]; selinexor promotes the reaction [INCB057643 results in decreased expression of MYC mRNA]; selinexor promotes the reaction [INCB057643 results in decreased expression of MYC protein]
selinexor results in decreased expression of MYC mRNA; selinexor results in decreased expression of MYC protein		 CTD PMID:37899423 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions ISO [INCB057643 co-treated with selinexor] results in increased expression of PMAIP1 protein CTD PMID:37899423 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions		 ISO selinexor results in increased expression of TP53 protein
[INCB057643 co-treated with selinexor] results in increased expression of TP53 protein		 CTD PMID:37899423 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp73 tumor protein p73 increases expression ISO selinexor results in increased expression of TP73 protein CTD PMID:37899423 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128 		JBrowse link
G Wee1 WEE1 G2 checkpoint kinase multiple interactions ISO [selinexor co-treated with INCB057643] results in decreased phosphorylation of WEE1 protein CTD PMID:37899423 NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        biochemical role 19556
          exportin 1 inhibitor 12
            KPT-350 0
            XPO1-IN-1 0
            eltanexor 0
            selinexor 12
paths to the root