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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:butenedioic acid
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Accession:CHEBI:22958 term browser browse the term
Definition:A C4-dicarboxylic acid that has formula C4H4O4.
Synonyms:exact_synonym: but-2-enedioic acid
 related_synonym: 2-butenedioic acid;   Formula=C4H4O4;   InChI=1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8);   InChIKey=VZCYOOQTPOCHFL-UHFFFAOYSA-N;   SMILES=[H]C(=C([H])C(O)=O)C(O)=O
 xref: Beilstein:8132074
 cyclic_relationship: is_conjugate_acid_of CHEBI:37155



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citraconic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bach1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 affects localization ISO citraconic acid affects the localization of BACH1 protein CTD PMID:27277809 NCBI chr16:87,495,842...87,530,234
Ensembl chr16:87,495,833...87,530,234
JBrowse link
G Foxm1 forkhead box M1 increases expression ISO citraconic acid results in increased expression of FOXM1 protein CTD PMID:28289076 NCBI chr 6:128,339,957...128,352,849
Ensembl chr 6:128,339,930...128,353,109
JBrowse link
G Fth1 ferritin heavy polypeptide 1 increases expression ISO citraconic acid results in increased expression of FTH1 protein CTD PMID:28289076 NCBI chr19:9,957,964...9,962,475
Ensembl chr19:9,957,962...9,962,462
JBrowse link
G Ftl1 ferritin light polypeptide 1 increases expression
multiple interactions
ISO citraconic acid results in increased expression of FTL protein
citraconic acid promotes the reaction [NFE2L2 protein results in increased expression of FTL protein]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of FTL protein]
CTD PMID:28289076 NCBI chr 7:45,107,368...45,109,310
Ensembl chr 7:45,107,368...45,109,308
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO
EXP
citraconic acid results in increased expression of GCLC protein
citraconic acid results in increased expression of GCLC mRNA
CTD PMID:27277809 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression EXP
ISO
citraconic acid results in increased expression of GCLM mRNA
citraconic acid results in increased expression of GCLM protein
CTD PMID:27277809 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
JBrowse link
G Gsr glutathione reductase increases expression ISO
EXP
citraconic acid results in increased expression of GSR protein
citraconic acid results in increased expression of GSR mRNA
CTD PMID:27277809 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP
ISO
citraconic acid results in increased expression of HMOX1 mRNA
citraconic acid results in increased expression of HMOX1 mRNA; citraconic acid results in increased expression of HMOX1 protein
CTD PMID:27277809 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G mt-Cytb cytochrome b, mitochondrial increases expression
multiple interactions
EXP citraconic acid results in increased expression of CYTB mRNA
NFE2L2 protein affects the reaction [citraconic acid results in increased expression of CYTB mRNA]
CTD PMID:27277809 NCBI chr MT:14,145...15,288
Ensembl chr MT:14,145...15,288
JBrowse link
G mt-Nd1 NADH dehydrogenase 1, mitochondrial increases expression
multiple interactions
EXP citraconic acid results in increased expression of ND1 mRNA
NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND1 mRNA]
CTD PMID:27277809 NCBI chr MT:2,751...3,707
Ensembl chr MT:2,751...3,707
JBrowse link
G mt-Nd5 NADH dehydrogenase 5, mitochondrial multiple interactions
increases expression
EXP NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND5 mRNA] CTD PMID:27277809 NCBI chr MT:11,742...13,565
Ensembl chr MT:11,742...13,565
JBrowse link
G mt-Nd6 NADH dehydrogenase 6, mitochondrial multiple interactions
increases expression
EXP NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND6 mRNA] CTD PMID:27277809 NCBI chr MT:13,552...14,070
Ensembl chr MT:13,552...14,070
JBrowse link
G Mterf1a mitochondrial transcription termination factor 1a increases expression EXP citraconic acid results in increased expression of MTERF1A mRNA CTD PMID:27277809 NCBI chr 5:3,914,576...3,943,933
Ensembl chr 5:3,940,581...3,943,933
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 affects localization
multiple interactions
ISO
EXP
citraconic acid affects the localization of NFE2L2 protein
citraconic acid promotes the reaction [NFE2L2 protein results in increased expression of FTL protein]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of FTL protein]
NFE2L2 protein affects the reaction [citraconic acid results in increased expression of CYTB mRNA]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND1 mRNA]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND5 mRNA]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of ND6 mRNA]; NFE2L2 protein affects the reaction [citraconic acid results in increased expression of POLRMT mRNA]
CTD PMID:27277809 PMID:28289076 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression ISO citraconic acid results in increased expression of NQO1 mRNA; citraconic acid results in increased expression of NQO1 protein CTD PMID:27277809 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Polrmt polymerase (RNA) mitochondrial (DNA directed) multiple interactions
increases expression
EXP NFE2L2 protein affects the reaction [citraconic acid results in increased expression of POLRMT mRNA] CTD PMID:27277809 NCBI chr10:79,571,951...79,582,436
Ensembl chr10:79,571,957...79,582,415
JBrowse link
diethyl fumarate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases cleavage ISO diethyl fumarate results in increased cleavage of CASP3 protein CTD PMID:21105742 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO diethyl fumarate results in increased cleavage of PARP1 protein CTD PMID:21105742 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Sptan1 spectrin alpha, non-erythrocytic 1 increases cleavage ISO diethyl fumarate results in increased cleavage of SPTAN1 protein CTD PMID:21105742 NCBI chr 2:29,855,572...29,921,463
Ensembl chr 2:29,855,572...29,921,463
JBrowse link
G Star steroidogenic acute regulatory protein increases expression EXP diethyl fumarate results in increased expression of STAR protein CTD PMID:34768887 NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010
JBrowse link
diethyl maleate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP-binding cassette, sub-family C member 2 increases expression EXP diethyl maleate results in increased expression of ABCC2 mRNA CTD PMID:25270620 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
JBrowse link
G Abhd4 abhydrolase domain containing 4 increases expression EXP diethyl maleate results in increased expression of ABHD4 mRNA CTD PMID:25270620 NCBI chr14:54,491,586...54,506,626
Ensembl chr14:54,491,645...54,508,094
JBrowse link
G Acaca acetyl-Coenzyme A carboxylase alpha decreases expression EXP diethyl maleate results in decreased expression of ACACA mRNA CTD PMID:25270620 NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477
JBrowse link
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl multiple interactions ISO diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]; resveratrol inhibits the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol promotes the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]] CTD PMID:17134953 NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871
JBrowse link
G Acy3 aminoacylase 3 decreases expression ISO diethyl maleate results in decreased expression of ACY3 mRNA CTD PMID:21161181 NCBI chr19:4,036,570...4,040,007
Ensembl chr19:4,036,570...4,040,007
JBrowse link
G Adm adrenomedullin increases expression ISO diethyl maleate results in increased expression of ADM mRNA CTD PMID:33545341 NCBI chr 7:110,226,864...110,229,027
Ensembl chr 7:110,226,868...110,229,027
JBrowse link
G Adora3 adenosine A3 receptor decreases expression ISO diethyl maleate results in decreased expression of ADORA3 mRNA CTD PMID:21161181 NCBI chr 3:105,811,737...105,816,244
Ensembl chr 3:105,778,174...105,816,242
JBrowse link
G Aen apoptosis enhancing nuclease increases expression ISO diethyl maleate results in increased expression of AEN mRNA CTD PMID:33545341 NCBI chr 7:78,545,675...78,560,957
Ensembl chr 7:78,545,602...78,560,957
JBrowse link
G Afp alpha fetoprotein increases expression EXP diethyl maleate results in increased expression of AFP mRNA CTD PMID:25270620 NCBI chr 5:90,638,573...90,656,766
Ensembl chr 5:90,638,596...90,656,766
JBrowse link
G Ahcyl1 S-adenosylhomocysteine hydrolase-like 1 increases expression EXP diethyl maleate results in increased expression of AHCYL1 mRNA CTD PMID:25270620 NCBI chr 3:107,570,436...107,603,876
Ensembl chr 3:107,570,434...107,603,876
JBrowse link
G Akr1a1 aldo-keto reductase family 1, member A1 increases expression ISO diethyl maleate results in increased expression of AKR1A1 protein CTD PMID:21161181 NCBI chr 4:116,493,707...116,508,871
Ensembl chr 4:116,493,707...116,508,877
JBrowse link
G Akr1b10 aldo-keto reductase family 1, member B10 increases expression ISO diethyl maleate results in increased expression of AKR1B10 mRNA CTD PMID:33545341 NCBI chr 6:34,361,182...34,373,884
Ensembl chr 6:34,361,153...34,373,885
JBrowse link
G Akr1c19 aldo-keto reductase family 1, member C19 increases expression EXP diethyl maleate results in increased expression of AKR1C19 mRNA CTD PMID:25270620 NCBI chr13:4,283,499...4,298,360
Ensembl chr13:4,278,699...4,302,842
JBrowse link
G Akr1c21 aldo-keto reductase family 1, member C21 increases expression ISO diethyl maleate results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540
JBrowse link
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 affects reduction EXP diethyl maleate affects the reduction of ALDH1A1 protein CTD PMID:19843705 NCBI chr19:20,469,947...20,620,827
Ensembl chr19:20,470,079...20,620,829
JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 decreases expression ISO diethyl maleate results in decreased expression of ALDH1B1 mRNA CTD PMID:21161181 NCBI chr 4:45,799,022...45,804,608
Ensembl chr 4:45,799,022...45,804,604
JBrowse link
G Aldh2 aldehyde dehydrogenase 2, mitochondrial decreases reduction
increases expression
decreases expression
EXP
ISO
diethyl maleate results in decreased reduction of ALDH2 protein
diethyl maleate results in increased expression of ALDH2 protein
diethyl maleate results in decreased expression of ALDH2 protein
CTD PMID:19843705 PMID:21161181 NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887
JBrowse link
G Aldob aldolase B, fructose-bisphosphate decreases expression ISO diethyl maleate results in decreased expression of ALDOB protein CTD PMID:21161181 NCBI chr 4:49,535,993...49,549,546
Ensembl chr 4:49,535,995...49,549,546
JBrowse link
G Amigo2 adhesion molecule with Ig like domain 2 decreases expression ISO diethyl maleate results in decreased expression of AMIGO2 mRNA CTD PMID:21161181 NCBI chr15:97,141,955...97,145,168
Ensembl chr15:97,142,006...97,145,168
JBrowse link
G Angptl2 angiopoietin-like 2 decreases expression ISO diethyl maleate results in decreased expression of ANGPTL2 mRNA CTD PMID:21161181 NCBI chr 2:33,105,963...33,137,737
Ensembl chr 2:33,106,081...33,137,729
JBrowse link
G Angptl4 angiopoietin-like 4 increases expression ISO diethyl maleate results in increased expression of ANGPTL4 mRNA CTD PMID:33545341 NCBI chr17:33,993,874...34,000,549
Ensembl chr17:33,992,724...34,000,804
JBrowse link
G Ankrd46 ankyrin repeat domain 46 decreases expression ISO diethyl maleate results in decreased expression of ANKRD46 mRNA CTD PMID:21161181 NCBI chr15:36,477,814...36,496,937
Ensembl chr15:36,477,814...36,496,966
JBrowse link
G Anln anillin, actin binding protein increases expression ISO diethyl maleate results in increased expression of ANLN mRNA CTD PMID:21161181 NCBI chr 9:22,243,305...22,302,132
Ensembl chr 9:22,243,308...22,300,484
JBrowse link
G Anxa1 annexin A1 affects expression ISO diethyl maleate affects the expression of ANXA1 mRNA CTD PMID:34480604 NCBI chr19:20,350,798...20,368,035
Ensembl chr19:20,350,792...20,368,308
JBrowse link
G Anxa3 annexin A3 decreases expression ISO diethyl maleate results in decreased expression of ANXA3 mRNA CTD PMID:21161181 NCBI chr 5:96,941,257...96,993,825
Ensembl chr 5:96,941,198...96,993,825
JBrowse link
G Ap3m2 adaptor-related protein complex 3, mu 2 subunit decreases expression ISO diethyl maleate results in decreased expression of AP3M2 mRNA CTD PMID:21161181 NCBI chr 8:23,277,370...23,297,308
Ensembl chr 8:23,277,370...23,295,638
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO diethyl maleate results in increased expression of APAF1 mRNA CTD PMID:11875189 NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632
JBrowse link
G Aplp1 amyloid beta precursor like protein 1 decreases expression EXP diethyl maleate results in decreased expression of APLP1 mRNA CTD PMID:25270620 NCBI chr 7:30,134,405...30,144,960
Ensembl chr 7:30,134,407...30,144,960
JBrowse link
G Apol9a apolipoprotein L 9a decreases expression ISO diethyl maleate results in decreased expression of APOL9A mRNA CTD PMID:21161181 NCBI chr15:77,287,989...77,295,280
Ensembl chr15:77,287,989...77,295,335
JBrowse link
G Arhgap9 Rho GTPase activating protein 9 increases expression ISO diethyl maleate results in increased expression of ARHGAP9 mRNA CTD PMID:33545341 NCBI chr10:127,157,829...127,165,816
Ensembl chr10:127,157,833...127,165,812
JBrowse link
G Arrdc2 arrestin domain containing 2 decreases expression ISO diethyl maleate results in decreased expression of ARRDC2 mRNA CTD PMID:21161181 NCBI chr 8:71,287,773...71,293,173
Ensembl chr 8:71,287,773...71,292,364
JBrowse link
G Arrdc4 arrestin domain containing 4 decreases expression EXP diethyl maleate results in decreased expression of ARRDC4 mRNA CTD PMID:25270620 NCBI chr 7:68,386,742...68,398,986
Ensembl chr 7:68,386,743...68,398,989
JBrowse link
G Asf1b anti-silencing function 1B histone chaperone increases expression ISO diethyl maleate results in increased expression of ASF1B mRNA CTD PMID:21161181 NCBI chr 8:84,682,323...84,696,824
Ensembl chr 8:84,682,136...84,696,826
JBrowse link
G Asxl1 ASXL transcriptional regulator 1 decreases expression EXP diethyl maleate results in decreased expression of ASXL1 mRNA CTD PMID:25270620 NCBI chr 2:153,187,750...153,245,927
Ensembl chr 2:153,187,749...153,245,927
JBrowse link
G Atm ataxia telangiectasia mutated increases expression ISO diethyl maleate results in increased expression of ATM mRNA CTD PMID:11875189 NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta increases expression ISO diethyl maleate results in increased expression of ATP5F1B protein CTD PMID:21161181 NCBI chr10:127,919,176...127,926,257
Ensembl chr10:127,919,142...127,926,260
JBrowse link
G Aurka aurora kinase A increases expression
decreases expression
ISO
EXP
diethyl maleate results in increased expression of AURKA mRNA
diethyl maleate results in decreased expression of AURKA mRNA
CTD PMID:21161181 PMID:25270620 NCBI chr 2:172,198,116...172,212,825
Ensembl chr 2:172,198,110...172,212,455
JBrowse link
G Bbc3 BCL2 binding component 3 increases expression ISO diethyl maleate results in increased expression of BBC3 mRNA CTD PMID:33545341 NCBI chr 7:16,042,307...16,052,130
Ensembl chr 7:16,042,318...16,052,130
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
increases expression
EXP
ISO
[diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of BCL2 mRNA
diethyl maleate results in increased expression of BCL2 mRNA
CTD PMID:22564015 PMID:33545341 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bcl2a1b B cell leukemia/lymphoma 2 related protein A1b decreases expression ISO diethyl maleate results in decreased expression of BCL2A1 mRNA CTD PMID:21161181 NCBI chr 9:89,081,326...89,089,891
Ensembl chr 9:89,081,262...89,089,880
JBrowse link
G Bcl3 B cell leukemia/lymphoma 3 decreases expression EXP diethyl maleate results in decreased expression of BCL3 mRNA CTD PMID:25270620 NCBI chr 7:19,542,387...19,556,691
Ensembl chr 7:19,542,387...19,556,695
JBrowse link
G Bcl6b B cell CLL/lymphoma 6, member B decreases expression ISO diethyl maleate results in decreased expression of BCL6B mRNA CTD PMID:21161181 NCBI chr11:70,114,953...70,120,624
Ensembl chr11:70,114,954...70,120,624
JBrowse link
G Bhlhe41 basic helix-loop-helix family, member e41 decreases expression ISO diethyl maleate results in decreased expression of BHLHE41 mRNA CTD PMID:21161181 NCBI chr 6:145,803,969...145,811,146
Ensembl chr 6:145,803,969...145,811,284
JBrowse link
G Bhmt betaine-homocysteine methyltransferase decreases expression ISO diethyl maleate results in decreased expression of BHMT mRNA CTD PMID:21161181 NCBI chr13:93,753,399...93,774,266
Ensembl chr13:93,753,183...93,774,469
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions EXP diethyl maleate inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA] CTD PMID:12774022 NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187
JBrowse link
G Blvrb biliverdin reductase B increases expression EXP diethyl maleate results in increased expression of BLVRB mRNA CTD PMID:25270620 PMID:34626751 NCBI chr 7:27,147,403...27,165,406
Ensembl chr 7:27,147,403...27,165,569
JBrowse link
G Bmf BCL2 modifying factor decreases expression ISO diethyl maleate results in decreased expression of BMF mRNA CTD PMID:21161181 NCBI chr 2:118,359,238...118,385,240
Ensembl chr 2:118,359,238...118,380,168
JBrowse link
G Brip1 BRCA1 interacting protein C-terminal helicase 1 increases expression ISO diethyl maleate results in increased expression of BRIP1 mRNA CTD PMID:21161181 NCBI chr11:85,948,957...86,092,041
Ensembl chr11:85,948,964...86,092,019
JBrowse link
G Btbd2 BTB domain containing 2 decreases expression ISO diethyl maleate results in decreased expression of BTBD2 mRNA CTD PMID:21161181 NCBI chr10:80,478,457...80,492,328
Ensembl chr10:80,478,451...80,492,328
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression
decreases expression
multiple interactions
EXP diethyl maleate results in increased expression of BTG2 mRNA
diethyl maleate results in decreased expression of BTG2 mRNA
NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]; TRP53 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]
CTD PMID:22003191 PMID:25270620 PMID:34626751 NCBI chr 1:134,002,603...134,006,893
Ensembl chr 1:134,002,908...134,006,858
JBrowse link
G C6 complement component 6 decreases expression ISO diethyl maleate results in decreased expression of C6 mRNA CTD PMID:21161181 NCBI chr15:4,756,550...4,833,527
Ensembl chr15:4,756,657...4,844,449
JBrowse link
G Casp2 caspase 2 increases expression ISO diethyl maleate results in increased expression of CASP2 mRNA CTD PMID:11875189 NCBI chr 6:42,241,942...42,259,442
Ensembl chr 6:42,241,919...42,259,442
JBrowse link
G Casp3 caspase 3 increases expression
increases cleavage
ISO diethyl maleate results in increased expression of CASP3 mRNA
diethyl maleate results in increased cleavage of CASP3 protein
CTD PMID:11875189 PMID:21105742 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp9 caspase 9 increases expression ISO diethyl maleate results in increased expression of CASP9 mRNA CTD PMID:11875189 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cat catalase decreases expression ISO diethyl maleate results in decreased expression of CAT protein CTD PMID:21161181 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Cbr1 carbonyl reductase 1 increases expression EXP diethyl maleate results in increased expression of CBR1 mRNA CTD PMID:25270620 NCBI chr16:93,404,752...93,407,226
Ensembl chr16:93,402,741...93,407,393
JBrowse link
G Cbr3 carbonyl reductase 3 increases expression
multiple interactions
ISO
EXP
diethyl maleate results in increased expression of CBR3 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [diethyl maleate results in increased expression of CBR3 mRNA]
CTD PMID:20806931 PMID:25270620 NCBI chr16:93,480,107...93,487,879
Ensembl chr16:93,480,103...93,487,878
JBrowse link
G Cbx4 chromobox 4 increases expression ISO diethyl maleate results in increased expression of CBX4 mRNA CTD PMID:33545341 NCBI chr11:118,968,399...118,977,067
Ensembl chr11:118,968,399...118,977,047
JBrowse link
G Ccdc50 coiled-coil domain containing 50 decreases expression EXP diethyl maleate results in decreased expression of CCDC50 mRNA CTD PMID:25270620 NCBI chr16:27,205,815...27,270,968
Ensembl chr16:27,207,619...27,270,968
JBrowse link
G Ccna1 cyclin A1 decreases expression ISO diethyl maleate results in decreased expression of CCNA1 mRNA CTD PMID:11875189 NCBI chr 3:54,952,890...54,965,055
Ensembl chr 3:54,952,890...54,962,922
JBrowse link
G Ccna2 cyclin A2 increases expression ISO diethyl maleate results in increased expression of CCNA2 mRNA CTD PMID:21161181 NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299
JBrowse link
G Ccnd1 cyclin D1 decreases expression
increases expression
ISO
EXP
diethyl maleate results in decreased expression of CCND1 mRNA
diethyl maleate results in increased expression of CCND1 mRNA
CTD PMID:11875189 PMID:21161181 PMID:25270620 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Ccne2 cyclin E2 increases expression ISO diethyl maleate results in increased expression of CCNE2 mRNA CTD PMID:21161181 NCBI chr 4:11,190,489...11,204,781
Ensembl chr 4:11,191,351...11,204,779
JBrowse link
G Ccnk cyclin K decreases expression ISO diethyl maleate results in decreased expression of CCNK mRNA CTD PMID:11875189 NCBI chr12:108,145,543...108,170,252
Ensembl chr12:108,145,838...108,169,618
JBrowse link
G Cd80 CD80 antigen multiple interactions
increases expression
ISO [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein
diethyl maleate results in increased expression of CD80 protein
CTD PMID:31958493 NCBI chr16:38,277,793...38,316,682
Ensembl chr16:38,275,923...38,316,697
JBrowse link
G Cd86 CD86 antigen multiple interactions
increases expression
ISO [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein; bisindolylmaleimide I inhibits the reaction [diethyl maleate results in increased expression of CD86 protein] CTD PMID:24136171 PMID:31958493 NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443
JBrowse link
G Cdc25a cell division cycle 25A increases expression ISO diethyl maleate results in increased expression of CDC25A mRNA CTD PMID:21161181 NCBI chr 9:109,704,545...109,722,963
Ensembl chr 9:109,704,647...109,722,963
JBrowse link
G Cdca2 cell division cycle associated 2 increases expression ISO diethyl maleate results in increased expression of CDCA2 mRNA CTD PMID:21161181 NCBI chr14:67,910,629...67,953,290
Ensembl chr14:67,913,780...67,953,290
JBrowse link
G Cdca3 cell division cycle associated 3 increases expression ISO diethyl maleate results in increased expression of CDCA3 mRNA CTD PMID:21161181 NCBI chr 6:124,806,533...124,810,664
Ensembl chr 6:124,806,510...124,810,664
JBrowse link
G Cdca8 cell division cycle associated 8 increases expression ISO diethyl maleate results in increased expression of CDCA8 mRNA CTD PMID:21161181 NCBI chr 4:124,812,258...124,830,710
Ensembl chr 4:124,812,258...124,833,104
JBrowse link
G Cdh11 cadherin 11 decreases expression ISO diethyl maleate results in decreased expression of CDH11 mRNA CTD PMID:21161181 NCBI chr 8:103,358,727...103,512,125
Ensembl chr 8:103,358,727...103,512,274
JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression
multiple interactions
ISO diethyl maleate results in increased expression of CDKN1A mRNA; diethyl maleate results in increased expression of CDKN1A protein
TP53 protein affects the reaction [diethyl maleate results in increased expression of CDKN1A protein]
CTD PMID:11875189 PMID:27982581 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Cds2 CDP-diacylglycerol synthase 2 increases expression EXP diethyl maleate results in increased expression of CDS2 mRNA CTD PMID:25270620 NCBI chr 2:132,105,068...132,153,970
Ensembl chr 2:132,105,068...132,153,970
JBrowse link
G Ces1d carboxylesterase 1D increases reduction
decreases expression
EXP
ISO
diethyl maleate results in increased reduction of CES1D protein
diethyl maleate results in decreased expression of CES1D protein
CTD PMID:19843705 PMID:21161181 NCBI chr 8:93,892,700...93,924,432
Ensembl chr 8:93,892,696...93,924,466
JBrowse link
G Ces2a carboxylesterase 2A increases reduction EXP diethyl maleate results in increased reduction of CES2A protein CTD PMID:19843705 NCBI chr 8:105,460,635...105,468,266
Ensembl chr 8:105,460,635...105,468,266
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression ISO diethyl maleate results in decreased expression of CFLAR mRNA CTD PMID:21161181 NCBI chr 1:58,750,353...58,798,043
Ensembl chr 1:58,750,667...58,798,043
JBrowse link
G Chrna4 cholinergic receptor, nicotinic, alpha polypeptide 4 increases expression ISO diethyl maleate results in increased expression of CHRNA4 mRNA CTD PMID:33545341 NCBI chr 2:180,664,104...180,685,339
Ensembl chr 2:180,660,173...180,685,339
JBrowse link
G Cidec cell death-inducing DFFA-like effector c decreases expression ISO diethyl maleate results in decreased expression of CIDEC mRNA CTD PMID:21161181 NCBI chr 6:113,401,595...113,412,721
Ensembl chr 6:113,401,595...113,412,721
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression ISO diethyl maleate results in decreased expression of CITED2 mRNA CTD PMID:21161181 NCBI chr10:17,598,452...17,601,422
Ensembl chr10:17,598,966...17,601,422
JBrowse link
G Cited4 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 decreases expression ISO diethyl maleate results in decreased expression of CITED4 mRNA CTD PMID:21161181 NCBI chr 4:120,523,760...120,525,017
Ensembl chr 4:120,523,769...120,525,017
JBrowse link
G Ckb creatine kinase, brain decreases reduction EXP diethyl maleate results in decreased reduction of CKB protein CTD PMID:19843705 NCBI chr12:111,635,789...111,638,772
Ensembl chr12:111,635,795...111,638,772
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 increases expression ISO diethyl maleate results in increased expression of CKS2 mRNA CTD PMID:33545341 NCBI chr13:51,799,268...51,804,698
Ensembl chr13:51,799,268...51,804,696
JBrowse link
G Clk1 CDC-like kinase 1 increases expression ISO diethyl maleate results in increased expression of CLK1 mRNA CTD PMID:33545341 NCBI chr 1:58,451,147...58,463,247
Ensembl chr 1:58,449,348...58,463,225
JBrowse link
G Cmpk2 cytidine/uridine monophosphate kinase 2 decreases expression ISO diethyl maleate results in decreased expression of CMPK2 mRNA CTD PMID:21161181 NCBI chr12:26,519,121...26,529,836
Ensembl chr12:26,519,203...26,529,836
JBrowse link
G Cntn1 contactin 1 increases expression ISO diethyl maleate results in increased expression of CNTN1 mRNA CTD PMID:33545341 NCBI chr15:91,949,034...92,239,834
Ensembl chr15:91,949,046...92,239,848
JBrowse link
G Col1a1 collagen, type I, alpha 1 decreases expression ISO diethyl maleate results in decreased expression of COL1A1 mRNA CTD PMID:21161181 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868
JBrowse link
G Col3a1 collagen, type III, alpha 1 decreases expression EXP diethyl maleate results in decreased expression of COL3A1 mRNA CTD PMID:25270620 NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866
JBrowse link
G Commd3 COMM domain containing 3 increases expression EXP diethyl maleate results in increased expression of COMMD3 mRNA CTD PMID:25270620 NCBI chr 2:18,677,246...18,681,042
Ensembl chr 2:18,677,234...18,681,042
JBrowse link
G Comt catechol-O-methyltransferase decreases expression ISO diethyl maleate results in decreased expression of COMT mRNA CTD PMID:21161181 NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602
JBrowse link
G Cp ceruloplasmin decreases expression EXP diethyl maleate results in decreased expression of CP mRNA CTD PMID:25270620 NCBI chr 3:20,011,097...20,063,914
Ensembl chr 3:20,011,218...20,063,309
JBrowse link
G Cpsf4l cleavage and polyadenylation specific factor 4-like increases expression ISO diethyl maleate results in increased expression of CPSF4L mRNA CTD PMID:33545341 NCBI chr11:113,588,997...113,601,125
Ensembl chr11:113,588,998...113,600,843
JBrowse link
G Crym crystallin, mu decreases expression ISO diethyl maleate results in decreased expression of CRYM mRNA CTD PMID:21161181 NCBI chr 7:119,785,603...119,801,212
Ensembl chr 7:119,785,603...119,801,334
JBrowse link
G Csrp1 cysteine and glycine-rich protein 1 decreases expression ISO diethyl maleate results in decreased expression of CSRP1 mRNA CTD PMID:21161181 NCBI chr 1:135,614,650...135,679,970
Ensembl chr 1:135,647,799...135,679,970
JBrowse link
G Csrp3 cysteine and glycine-rich protein 3 decreases reduction EXP diethyl maleate results in decreased reduction of CSRP3 protein CTD PMID:19843705 NCBI chr 7:48,480,146...48,497,799
Ensembl chr 7:48,480,146...48,497,781
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression ISO diethyl maleate results in decreased expression of CXCL10 mRNA CTD PMID:21161181 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO diethyl maleate results in decreased expression of CXCL12 mRNA CTD PMID:21161181 NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 increases expression
multiple interactions
increases secretion
increases stability
ISO diethyl maleate results in increased expression of CXCL8 mRNA; diethyl maleate results in increased expression of CXCL8 protein
bisindolylmaleimide I inhibits the reaction [diethyl maleate results in increased expression of CXCL8 protein]
diethyl maleate results in increased secretion of CXCL8 protein
diethyl maleate results in increased stability of CXCL8 mRNA
CTD PMID:20491607 PMID:20541004 PMID:21920952 PMID:21969073 PMID:24136171 More... NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 decreases expression ISO diethyl maleate results in decreased expression of CXCL9 mRNA CTD PMID:21161181 NCBI chr 5:92,469,190...92,475,938
Ensembl chr 5:92,469,206...92,475,938
JBrowse link
G Cyb5a cytochrome b5 type A (microsomal) increases expression EXP diethyl maleate results in increased expression of CYB5A mRNA CTD PMID:25270620 NCBI chr18:84,869,463...84,897,996
Ensembl chr18:84,856,829...84,897,996
JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 decreases expression ISO diethyl maleate results in decreased expression of CYP26B1 mRNA CTD PMID:21161181 NCBI chr 6:84,548,396...84,570,890
Ensembl chr 6:84,548,396...84,570,890
JBrowse link
G D17H6S56E-5 DNA segment, Chr 17, human D6S56E 5 decreases expression EXP diethyl maleate results in decreased expression of D17H6S56E-5 mRNA CTD PMID:25270620 NCBI chr17:35,215,654...35,219,722
Ensembl chr17:35,215,654...35,220,489
JBrowse link
G Dbp D site albumin promoter binding protein decreases expression ISO diethyl maleate results in decreased expression of DBP mRNA CTD PMID:21161181 NCBI chr 7:45,354,658...45,359,579
Ensembl chr 7:45,354,512...45,359,627
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO diethyl maleate results in increased expression of DDIT3 mRNA; diethyl maleate results in increased expression of DDIT3 protein CTD PMID:33545341 PMID:35724838 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO diethyl maleate results in increased expression of DDIT4 mRNA CTD PMID:33545341 NCBI chr10:59,785,497...59,787,592
Ensembl chr10:59,785,491...59,787,656
JBrowse link
G Ddit4l DNA-damage-inducible transcript 4-like increases expression EXP diethyl maleate results in increased expression of DDIT4L mRNA CTD PMID:25270620 NCBI chr 3:137,329,433...137,334,093
Ensembl chr 3:137,327,373...137,334,094
JBrowse link
G Ddx60 DExD/H box helicase 60 decreases expression ISO diethyl maleate results in decreased expression of DDX60 mRNA CTD PMID:21161181 NCBI chr 8:62,381,155...62,491,278
Ensembl chr 8:62,381,121...62,491,278
JBrowse link
G Dhx58 DExH-box helicase 58 decreases expression ISO diethyl maleate results in decreased expression of DHX58 mRNA CTD PMID:21161181 NCBI chr11:100,585,710...100,595,165
Ensembl chr11:100,585,710...100,595,097
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 increases expression ISO diethyl maleate results in increased expression of DNAJB1 mRNA CTD PMID:33545341 PMID:34480604 NCBI chr 8:84,334,804...84,339,282
Ensembl chr 8:84,334,822...84,339,282
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO diethyl maleate results in increased expression of DNAJB4 mRNA CTD PMID:33545341 NCBI chr 3:151,887,217...151,915,720
Ensembl chr 3:151,884,148...151,915,939
JBrowse link
G Dnmbp dynamin binding protein decreases expression ISO diethyl maleate results in decreased expression of DNMBP mRNA CTD PMID:21161181 NCBI chr19:43,835,259...43,930,930
Ensembl chr19:43,835,260...43,928,630
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 decreases reduction EXP diethyl maleate results in decreased reduction of DPYSL2 protein CTD PMID:19843705 NCBI chr14:67,040,313...67,148,490
Ensembl chr14:67,040,313...67,148,410
JBrowse link
G Dtx3l deltex 3-like, E3 ubiquitin ligase decreases expression ISO diethyl maleate results in decreased expression of DTX3L mRNA CTD PMID:21161181 NCBI chr16:35,746,885...35,759,397
Ensembl chr16:35,746,881...35,759,521
JBrowse link
G Dus3l dihydrouridine synthase 3 like decreases expression EXP diethyl maleate results in decreased expression of DUS3L mRNA CTD PMID:25270620 NCBI chr17:57,069,224...57,077,093
Ensembl chr17:57,071,757...57,077,093
JBrowse link
G Dusp6 dual specificity phosphatase 6 increases expression ISO diethyl maleate results in increased expression of DUSP6 mRNA CTD PMID:33545341 NCBI chr10:99,098,676...99,103,351
Ensembl chr10:99,099,093...99,103,351
JBrowse link
G Eef2k eukaryotic elongation factor-2 kinase decreases expression ISO diethyl maleate results in decreased expression of EEF2K mRNA CTD PMID:21161181 NCBI chr 7:120,442,080...120,506,441
Ensembl chr 7:120,442,054...120,506,673
JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 increases expression ISO diethyl maleate results in increased expression of EGLN3 mRNA CTD PMID:34480604 NCBI chr12:54,225,767...54,250,660
Ensembl chr12:54,225,767...54,250,646
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 decreases expression ISO diethyl maleate results in decreased expression of EIF2AK2 mRNA CTD PMID:21161181 NCBI chr17:79,157,933...79,190,001
Ensembl chr17:79,159,993...79,190,002
JBrowse link
G Entpd5 ectonucleoside triphosphate diphosphohydrolase 5 increases expression EXP diethyl maleate results in increased expression of ENTPD5 mRNA CTD PMID:25270620 NCBI chr12:84,420,649...84,455,803
Ensembl chr12:84,420,631...84,455,803
JBrowse link
G Eras ES cell-expressed Ras decreases expression EXP diethyl maleate results in decreased expression of ERAS mRNA CTD PMID:25270620 NCBI chr  X:7,790,515...7,794,846
Ensembl chr  X:7,790,515...7,794,846
JBrowse link
G Ercc6l excision repair cross-complementing rodent repair deficiency complementation group 6 like increases expression ISO diethyl maleate results in increased expression of ERCC6L mRNA CTD PMID:21161181 NCBI chr  X:101,186,426...101,200,697
Ensembl chr  X:101,185,322...101,200,697
JBrowse link
G Exo1 exonuclease 1 increases expression ISO diethyl maleate results in increased expression of EXO1 mRNA CTD PMID:21161181 NCBI chr 1:175,708,334...175,738,962
Ensembl chr 1:175,708,147...175,741,055
JBrowse link
G Fabp1 fatty acid binding protein 1, liver increases expression ISO diethyl maleate results in increased expression of FABP1 protein CTD PMID:21161181 NCBI chr 6:71,176,863...71,182,018
Ensembl chr 6:71,176,811...71,182,007
JBrowse link
G Fabp7 fatty acid binding protein 7, brain decreases expression ISO diethyl maleate results in decreased expression of FABP7 mRNA CTD PMID:21161181 NCBI chr10:57,661,019...57,664,546
Ensembl chr10:57,660,977...57,664,546
JBrowse link
G Fah fumarylacetoacetate hydrolase affects expression ISO diethyl maleate affects the expression of FAH mRNA CTD PMID:34480604 NCBI chr 7:84,234,367...84,255,150
Ensembl chr 7:84,234,367...84,255,930
JBrowse link
G Fam83d family with sequence similarity 83, member D increases expression ISO diethyl maleate results in increased expression of FAM83D mRNA CTD PMID:33545341 NCBI chr 2:158,610,011...158,628,557
Ensembl chr 2:158,610,013...158,628,557
JBrowse link
G Fasn fatty acid synthase decreases expression ISO diethyl maleate results in decreased expression of FASN mRNA CTD PMID:21161181 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373
JBrowse link
G Fbn1 fibrillin 1 decreases expression ISO diethyl maleate results in decreased expression of FBN1 mRNA CTD PMID:21161181 NCBI chr 2:125,142,514...125,348,417
Ensembl chr 2:125,142,514...125,349,913
JBrowse link
G Fbp1 fructose bisphosphatase 1 decreases expression ISO diethyl maleate results in decreased expression of FBP1 protein CTD PMID:21161181 NCBI chr13:63,012,567...63,036,112
Ensembl chr13:63,012,567...63,036,096
JBrowse link
G Fgf17 fibroblast growth factor 17 decreases expression EXP diethyl maleate results in decreased expression of FGF17 mRNA CTD PMID:25270620 NCBI chr14:70,873,643...70,880,064
Ensembl chr14:70,873,643...70,879,708
JBrowse link
G Fgg fibrinogen gamma chain decreases expression EXP diethyl maleate results in decreased expression of FGG mRNA CTD PMID:25270620 NCBI chr 3:82,915,031...82,922,363
Ensembl chr 3:82,915,031...82,922,356
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase decreases expression ISO diethyl maleate results in decreased expression of FGR mRNA CTD PMID:21161181 NCBI chr 4:132,701,406...132,729,204
Ensembl chr 4:132,701,406...132,729,221
JBrowse link
G Fndc3b fibronectin type III domain containing 3B decreases expression EXP diethyl maleate results in decreased expression of FNDC3B mRNA CTD PMID:25270620 NCBI chr 3:27,470,284...27,765,469
Ensembl chr 3:27,470,311...27,765,456
JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression EXP
ISO
diethyl maleate results in increased expression of FOS mRNA CTD PMID:10915739 PMID:33545341 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO diethyl maleate inhibits the reaction [INS protein affects the localization of and results in increased phosphorylation of FOXO1 protein] CTD PMID:30261343 NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642
JBrowse link
G Foxo3 forkhead box O3 increases expression ISO diethyl maleate results in increased expression of FOXO3 mRNA CTD PMID:33545341 NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751
JBrowse link
G Fstl3 follistatin-like 3 increases expression ISO diethyl maleate results in increased expression of FSTL3 mRNA CTD PMID:33545341 NCBI chr10:79,613,108...79,618,464
Ensembl chr10:79,613,106...79,618,464
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO
EXP
diethyl maleate results in decreased expression of G6PC1 mRNA CTD PMID:25270620 PMID:30261343 NCBI chr11:101,258,542...101,268,729
Ensembl chr11:101,258,387...101,268,729
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked increases activity
increases expression
ISO diethyl maleate results in increased activity of G6PD protein
diethyl maleate results in increased expression of G6PD mRNA
CTD PMID:3099627 PMID:30261343 PMID:33545341 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800
JBrowse link
G Gab1 growth factor receptor bound protein 2-associated protein 1 decreases expression EXP diethyl maleate results in decreased expression of GAB1 mRNA CTD PMID:25270620 NCBI chr 8:81,491,060...81,607,151
Ensembl chr 8:81,491,063...81,607,148
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha increases expression ISO diethyl maleate results in increased expression of GADD45A mRNA CTD PMID:33545341 PMID:34480604 NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible 45 gamma increases expression ISO diethyl maleate results in increased expression of GADD45G mRNA CTD PMID:33545341 NCBI chr13:52,000,711...52,002,511
Ensembl chr13:52,000,714...52,002,504
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases reduction EXP diethyl maleate results in increased reduction of GAPDH protein CTD PMID:19843705 NCBI chr 6:125,138,812...125,143,450
Ensembl chr 6:125,138,678...125,143,430
JBrowse link
G Gba2 glucosidase beta 2 decreases expression EXP diethyl maleate results in decreased expression of GBA2 mRNA CTD PMID:25270620 NCBI chr 4:43,566,928...43,578,893
Ensembl chr 4:43,566,928...43,578,873
JBrowse link
G Gbp2 guanylate binding protein 2 decreases expression ISO diethyl maleate results in decreased expression of GBP2 mRNA CTD PMID:21161181 NCBI chr 3:142,326,424...142,343,769
Ensembl chr 3:142,326,363...142,343,769
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases activity
increases expression
EXP
ISO
diethyl maleate results in increased activity of GCLC protein
diethyl maleate results in increased expression of GCLC mRNA; diethyl maleate results in increased expression of GCLC protein
CTD PMID:10915739 PMID:10978506 PMID:15115889 PMID:21465251 PMID:25270620 More... NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression ISO
EXP
diethyl maleate results in increased expression of GCLM mRNA; diethyl maleate results in increased expression of GCLM protein CTD PMID:10978506 PMID:15115889 PMID:21465251 PMID:25270620 PMID:33545341 More... NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
JBrowse link
G Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type increases expression ISO diethyl maleate results in increased expression of GCNT3 mRNA CTD PMID:33545341 NCBI chr 9:69,938,777...69,947,172
Ensembl chr 9:69,938,778...69,945,370
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO diethyl maleate results in increased expression of GDF15 mRNA CTD PMID:33545341 NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106
JBrowse link
G Gdf9 growth differentiation factor 9 increases expression ISO diethyl maleate results in increased expression of GDF9 mRNA CTD PMID:33545341 NCBI chr11:53,321,773...53,328,731
Ensembl chr11:53,321,850...53,328,731
JBrowse link
G Gfod1 glucose-fructose oxidoreductase domain containing 1 increases expression ISO diethyl maleate results in increased expression of GFOD1 mRNA CTD PMID:33545341 NCBI chr13:43,348,716...43,457,648
Ensembl chr13:43,348,721...43,457,648
JBrowse link
G Glul glutamate-ammonia ligase decreases expression EXP diethyl maleate results in decreased expression of GLUL mRNA CTD PMID:25270620 NCBI chr 1:153,775,692...153,785,469
Ensembl chr 1:153,775,690...153,785,469
JBrowse link
G Got2 glutamatic-oxaloacetic transaminase 2, mitochondrial decreases expression ISO diethyl maleate results in decreased expression of GOT2 protein CTD PMID:21161181 NCBI chr 8:96,590,761...96,615,029
Ensembl chr 8:96,590,762...96,615,175
JBrowse link
G Gpihbp1 GPI-anchored HDL-binding protein 1 decreases expression EXP diethyl maleate results in decreased expression of GPIHBP1 mRNA CTD PMID:25270620 NCBI chr15:75,468,479...75,470,062
Ensembl chr15:75,468,477...75,471,330
JBrowse link
G Gpx2 glutathione peroxidase 2 affects expression ISO diethyl maleate affects the expression of GPX2 mRNA CTD PMID:34480604 NCBI chr12:76,839,109...76,842,328
Ensembl chr12:76,839,107...76,842,273
JBrowse link
G Gria3 glutamate receptor, ionotropic, AMPA3 (alpha 3) decreases expression ISO diethyl maleate results in decreased expression of GRIA3 mRNA CTD PMID:21161181 NCBI chr  X:40,489,351...40,767,478
Ensembl chr  X:40,489,731...40,767,478
JBrowse link
G Gsn gelsolin decreases reduction EXP diethyl maleate results in decreased reduction of GSN protein CTD PMID:19843705 NCBI chr 2:35,146,371...35,197,914
Ensembl chr 2:35,146,392...35,197,904
JBrowse link
G Gsr glutathione reductase increases expression EXP diethyl maleate results in increased expression of GSR mRNA CTD PMID:25270620 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
JBrowse link
G Gss glutathione synthetase increases expression ISO diethyl maleate results in increased expression of GSS mRNA CTD PMID:10978506 NCBI chr 2:155,405,101...155,434,730
Ensembl chr 2:155,405,101...155,434,730
JBrowse link
G Gsta1 glutathione S-transferase, alpha 1 (Ya) increases expression ISO diethyl maleate results in increased expression of GSTA5 protein CTD PMID:9794803 NCBI chr 9:78,137,951...78,149,965
Ensembl chr 9:78,137,938...78,149,966
JBrowse link
G Gsta2 glutathione S-transferase, alpha 2 (Yc2) increases expression EXP diethyl maleate results in increased expression of GSTA2 mRNA CTD PMID:25270620 NCBI chr 9:78,238,300...78,254,474
Ensembl chr 9:78,238,300...78,263,070
JBrowse link
G Gsta4 glutathione S-transferase, alpha 4 increases expression EXP diethyl maleate results in increased expression of GSTA4 mRNA CTD PMID:25270620 NCBI chr 9:78,099,248...78,116,631
Ensembl chr 9:78,090,056...78,116,631
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 multiple interactions EXP [diethyl maleate results in decreased abundance of Glutathione] which results in decreased expression of GSTK1 mRNA CTD PMID:22564015 NCBI chr 6:42,222,869...42,227,375
Ensembl chr 6:42,222,869...42,227,381
JBrowse link
G Gstm1 glutathione S-transferase, mu 1 decreases expression ISO diethyl maleate results in decreased expression of GSTM1 protein CTD PMID:21161181 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289
JBrowse link
G Gsto1 glutathione S-transferase omega 1 increases expression EXP diethyl maleate results in increased expression of GSTO1 mRNA CTD PMID:25270620 NCBI chr19:47,843,412...47,853,229
Ensembl chr19:47,843,409...47,853,229
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 increases expression ISO diethyl maleate results in increased expression of GSTP1 protein CTD PMID:9794803 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
JBrowse link
G Gstt1 glutathione S-transferase, theta 1 increases expression ISO diethyl maleate results in increased expression of GSTT1 protein CTD PMID:9794803 NCBI chr10:75,619,647...75,634,418
Ensembl chr10:75,619,647...75,634,418
JBrowse link
G Gtse1 G two S phase expressed protein 1 increases expression ISO diethyl maleate results in increased expression of GTSE1 mRNA CTD PMID:21161181 NCBI chr15:85,743,928...85,760,774
Ensembl chr15:85,743,946...85,760,774
JBrowse link
G H2az2 H2A.Z histone variant 2 increases expression ISO diethyl maleate results in increased expression of H2AZ2 mRNA CTD PMID:33545341 NCBI chr11:6,377,226...6,394,511
Ensembl chr11:6,377,229...6,394,443
JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) increases expression EXP diethyl maleate results in increased expression of H6PD mRNA CTD PMID:25270620 NCBI chr 4:150,063,931...150,093,480
Ensembl chr 4:150,063,932...150,093,480
JBrowse link
G Hamp hepcidin antimicrobial peptide increases expression ISO diethyl maleate results in increased expression of HAMP mRNA CTD PMID:33545341 NCBI chr 7:30,641,793...30,643,454
Ensembl chr 7:30,641,793...30,643,457
JBrowse link
G Helb helicase (DNA) B decreases expression EXP diethyl maleate results in decreased expression of HELB mRNA CTD PMID:25270620 NCBI chr10:119,919,513...119,948,917
Ensembl chr10:119,919,513...119,948,892
JBrowse link
G Hes6 hairy and enhancer of split 6 decreases expression ISO diethyl maleate results in decreased expression of HES6 mRNA CTD PMID:21161181 NCBI chr 1:91,339,204...91,342,901
Ensembl chr 1:91,339,205...91,341,760
JBrowse link
G Hjurp Holliday junction recognition protein increases expression ISO diethyl maleate results in increased expression of HJURP mRNA CTD PMID:21161181 NCBI chr 1:88,186,578...88,205,366
Ensembl chr 1:88,190,193...88,205,355
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO
EXP
diethyl maleate results in increased expression of HMOX1 mRNA; diethyl maleate results in increased expression of HMOX1 protein CTD PMID:20491607 PMID:25270620 PMID:30261343 PMID:33545341 PMID:34480604 More... NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 decreases reduction EXP diethyl maleate results in decreased reduction of HNRNPH1 protein CTD PMID:19843705 NCBI chr11:50,266,084...50,277,355
Ensembl chr11:50,267,817...50,277,355
JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 increases expression ISO diethyl maleate results in increased expression of HSD17B10 mRNA CTD PMID:33545341 NCBI chr  X:150,784,892...150,787,438
Ensembl chr  X:150,784,841...150,787,438
JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 decreases expression ISO diethyl maleate results in decreased expression of HSD17B2 mRNA CTD PMID:21161181 NCBI chr 8:118,427,752...118,485,767
Ensembl chr 8:118,428,643...118,485,766
JBrowse link
G Hspa1b heat shock protein 1B increases expression ISO diethyl maleate results in increased expression of HSPA1B mRNA CTD PMID:33545341 NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214
JBrowse link
G Hspa1l heat shock protein 1-like increases expression ISO diethyl maleate results in increased expression of HSPA1L mRNA CTD PMID:33545341 NCBI chr17:35,191,679...35,198,204
Ensembl chr17:35,191,679...35,198,261
JBrowse link
G Hspa5 heat shock protein 5 decreases reduction EXP diethyl maleate results in decreased reduction of HSPA5 protein CTD PMID:19843705 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559
JBrowse link
G Hspa8 heat shock protein 8 increases reduction EXP diethyl maleate results in increased reduction of HSPA8 protein CTD PMID:19843705 NCBI chr 9:40,712,572...40,716,498
Ensembl chr 9:40,712,280...40,721,383
JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 increases expression EXP diethyl maleate results in increased expression of HTATIP2 mRNA CTD PMID:25270620 NCBI chr 7:49,408,761...49,423,748
Ensembl chr 7:49,408,863...49,423,723
JBrowse link
G Hycc2 hyccin PI4KA lipid kinase complex subunit 2 decreases expression ISO diethyl maleate results in decreased expression of HYCC2 mRNA CTD PMID:21161181 NCBI chr 1:58,561,965...58,625,492
Ensembl chr 1:58,561,965...58,625,482
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions
EXP
ISO
diethyl maleate results in decreased expression of ICAM1 mRNA
diethyl maleate inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; NFE2L2 protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; RELA protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]
CTD PMID:25270620 PMID:35724838 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
JBrowse link
G Id3 inhibitor of DNA binding 3 decreases expression EXP diethyl maleate results in decreased expression of ID3 mRNA CTD PMID:25270620 NCBI chr 4:135,871,133...135,872,703
Ensembl chr 4:135,870,808...135,873,066
JBrowse link
G Id4 inhibitor of DNA binding 4 decreases expression EXP diethyl maleate results in decreased expression of ID4 mRNA CTD PMID:25270620 NCBI chr13:48,414,592...48,419,504
Ensembl chr13:48,414,704...48,419,502
JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 decreases expression ISO diethyl maleate results in decreased expression of IFIT3 mRNA CTD PMID:21161181 NCBI chr19:34,560,519...34,566,382
Ensembl chr19:34,560,931...34,566,131
JBrowse link
G Ifrd1 interferon-related developmental regulator 1 increases expression ISO diethyl maleate results in increased expression of IFRD1 mRNA CTD PMID:33545341 NCBI chr12:40,253,128...40,273,184
Ensembl chr12:40,251,566...40,298,503
JBrowse link
G Ikbke inhibitor of kappaB kinase epsilon decreases expression EXP diethyl maleate results in decreased expression of IKBKE mRNA CTD PMID:25270620 NCBI chr 1:131,182,337...131,207,339
Ensembl chr 1:131,182,080...131,207,344
JBrowse link
G Ikbkg inhibitor of kappaB kinase gamma increases expression EXP diethyl maleate results in increased expression of IKBKG mRNA CTD PMID:25270620 NCBI chr  X:73,436,883...73,498,013
Ensembl chr  X:73,436,896...73,497,460
JBrowse link
G Il10 interleukin 10 increases secretion ISO diethyl maleate results in increased secretion of IL10 protein CTD PMID:31958493 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
JBrowse link
G Il18 interleukin 18 increases expression ISO diethyl maleate results in increased expression of IL18 protein CTD PMID:23063874 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO diethyl maleate inhibits the reaction [IL1B protein affects the localization of NFKBIA protein]; diethyl maleate inhibits the reaction [IL1B protein affects the localization of RELA protein]; diethyl maleate inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; diethyl maleate inhibits the reaction [IL1B protein results in increased expression of TNFAIP3 protein] CTD PMID:35724838 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il1r1 interleukin 1 receptor, type I affects expression ISO diethyl maleate affects the expression of IL1R1 mRNA CTD PMID:34480604 NCBI chr 1:40,261,651...40,355,361
Ensembl chr 1:40,264,240...40,356,417
JBrowse link
G Il4 interleukin 4 multiple interactions ISO [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein CTD PMID:31958493 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
JBrowse link
G Inhbb inhibin beta-B decreases expression EXP diethyl maleate results in decreased expression of INHBB mRNA CTD PMID:25270620 NCBI chr 1:119,343,193...119,349,978
Ensembl chr 1:119,343,195...119,349,978
JBrowse link
G Inmt indolethylamine N-methyltransferase decreases expression ISO diethyl maleate results in decreased expression of INMT mRNA CTD PMID:21161181 NCBI chr 6:55,147,612...55,151,975
Ensembl chr 6:55,147,611...55,152,028
JBrowse link
G Ins2 insulin II multiple interactions ISO diethyl maleate inhibits the reaction [INS protein affects the localization of and results in increased phosphorylation of FOXO1 protein] CTD PMID:30261343 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118
JBrowse link
G Ints7 integrator complex subunit 7 decreases expression EXP diethyl maleate results in decreased expression of INTS7 mRNA CTD PMID:25270620 NCBI chr 1:191,307,652...191,355,802
Ensembl chr 1:191,307,748...191,355,800
JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression ISO diethyl maleate results in decreased expression of IRF7 mRNA CTD PMID:21161181 NCBI chr 7:140,843,096...140,846,412
Ensembl chr 7:140,842,619...140,846,394
JBrowse link
G Irf9 interferon regulatory factor 9 decreases expression ISO diethyl maleate results in decreased expression of IRF9 mRNA CTD PMID:21161181 NCBI chr14:55,841,442...55,847,487
Ensembl chr14:55,841,028...55,847,487
JBrowse link
G Irgm1 immunity-related GTPase family M member 1 decreases expression ISO diethyl maleate results in decreased expression of IRGM mRNA CTD PMID:21161181 NCBI chr11:48,756,072...48,762,247
Ensembl chr11:48,752,795...48,762,510
JBrowse link
G Itgal integrin alpha L decreases expression ISO diethyl maleate results in decreased expression of ITGAL mRNA CTD PMID:21161181 NCBI chr 7:126,895,404...126,934,309
Ensembl chr 7:126,895,432...126,934,310
JBrowse link
G Itih3 inter-alpha trypsin inhibitor, heavy chain 3 decreases expression EXP diethyl maleate results in decreased expression of ITIH3 mRNA CTD PMID:25270620 NCBI chr14:30,630,529...30,645,748
Ensembl chr14:30,630,529...30,645,717
JBrowse link
G Itih4 inter alpha-trypsin inhibitor, heavy chain 4 decreases expression EXP diethyl maleate results in decreased expression of ITIH4 mRNA CTD PMID:25270620 NCBI chr14:30,608,433...30,623,943
Ensembl chr14:30,608,433...30,624,310
JBrowse link
G Jam3 junction adhesion molecule 3 decreases expression ISO diethyl maleate results in decreased expression of JAM3 mRNA CTD PMID:21161181 NCBI chr 9:27,008,680...27,066,739
Ensembl chr 9:27,008,680...27,066,717
JBrowse link
G Jun jun proto-oncogene multiple interactions
increases expression
increases phosphorylation
EXP
ISO
pyrazolanthrone inhibits the reaction [TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]]; TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]
diethyl maleate results in increased expression of JUN protein modified form
pyrazolanthrone inhibits the reaction [diethyl maleate results in increased expression of JUN protein modified form]
diethyl maleate results in increased expression of JUN mRNA
CTD PMID:10915739 PMID:12774022 PMID:30261343 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
JBrowse link
G Kcne3 potassium voltage-gated channel, Isk-related subfamily, gene 3 decreases expression EXP diethyl maleate results in decreased expression of KCNE3 mRNA CTD PMID:25270620 NCBI chr 7:99,825,714...99,834,076
Ensembl chr 7:99,825,709...99,834,076
JBrowse link
G Keap1 kelch-like ECH-associated protein 1 increases expression ISO diethyl maleate results in increased expression of KEAP1 mRNA; diethyl maleate results in increased expression of KEAP1 protein CTD PMID:27358234 PMID:33545341 PMID:34480604 NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657
JBrowse link
G Khdrbs3 KH domain containing, RNA binding, signal transduction associated 3 increases expression ISO diethyl maleate results in increased expression of KHDRBS3 mRNA CTD PMID:33545341 NCBI chr15:68,800,155...68,973,064
Ensembl chr15:68,800,269...68,973,060
JBrowse link
G Kifc1 kinesin family member C1 increases expression ISO diethyl maleate results in increased expression of KIFC1 mRNA CTD PMID:21161181 NCBI chr17:34,094,640...34,109,607
Ensembl chr17:34,094,633...34,109,635
JBrowse link
G Klf10 Kruppel-like transcription factor 10 decreases expression ISO
EXP
diethyl maleate results in decreased expression of KLF10 mRNA CTD PMID:21161181 PMID:25270620 NCBI chr15:38,291,702...38,300,950
Ensembl chr15:38,291,707...38,300,950
JBrowse link
G Krt75 keratin 75 increases reduction EXP diethyl maleate results in increased reduction of KRT75 protein CTD PMID:19843705 NCBI chr15:101,471,778...101,482,339
Ensembl chr15:101,471,780...101,482,339
JBrowse link
G Lama1 laminin, alpha 1 decreases expression EXP diethyl maleate results in decreased expression of LAMA1 mRNA CTD PMID:25270620 NCBI chr17:68,004,129...68,129,640
Ensembl chr17:68,004,254...68,129,642
JBrowse link
G Lancl2 LanC (bacterial lantibiotic synthetase component C)-like 2 decreases expression EXP diethyl maleate results in decreased expression of LANCL2 mRNA CTD PMID:25270620 NCBI chr 6:57,679,440...57,716,434
Ensembl chr 6:57,679,525...57,716,424
JBrowse link
G Ldlr low density lipoprotein receptor decreases expression ISO diethyl maleate results in decreased expression of LDLR mRNA CTD PMID:21161181 NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215
JBrowse link
G Lepr leptin receptor decreases expression ISO diethyl maleate results in decreased expression of LEPR mRNA CTD PMID:21161181 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549
JBrowse link
G Lgals3bp lectin, galactoside-binding, soluble, 3 binding protein decreases expression ISO diethyl maleate results in decreased expression of LGALS3BP mRNA CTD PMID:21161181 NCBI chr11:118,283,573...118,292,787
Ensembl chr11:118,283,577...118,292,918
JBrowse link
G Lmnb1 lamin B1 increases expression ISO diethyl maleate results in increased expression of LMNB1 mRNA CTD PMID:21161181 NCBI chr18:56,840,885...56,886,496
Ensembl chr18:56,840,885...56,886,496
JBrowse link
G Lmo7 LIM domain only 7 decreases expression ISO diethyl maleate results in decreased expression of LMO7 mRNA CTD PMID:21161181 NCBI chr14:101,967,353...102,172,144
Ensembl chr14:101,967,386...102,172,146
JBrowse link
G Lrig3 leucine-rich repeats and immunoglobulin-like domains 3 decreases expression ISO diethyl maleate results in decreased expression of LRIG3 mRNA CTD PMID:21161181 NCBI chr10:125,802,088...125,851,228
Ensembl chr10:125,802,037...125,851,228
JBrowse link
G Lrrn4 leucine rich repeat neuronal 4 increases expression ISO diethyl maleate results in increased expression of LRRN4 mRNA CTD PMID:21161181 NCBI chr 2:132,710,436...132,735,930
Ensembl chr 2:132,710,225...132,722,811
JBrowse link
G Lrtm2 leucine-rich repeats and transmembrane domains 2 decreases expression ISO diethyl maleate results in decreased expression of LRTM2 mRNA CTD PMID:21161181 NCBI chr 6:119,292,094...119,315,009
Ensembl chr 6:119,292,094...119,307,727
JBrowse link
G Ltc4s leukotriene C4 synthase decreases expression ISO diethyl maleate results in decreased expression of LTC4S mRNA CTD PMID:21161181 NCBI chr11:50,127,288...50,129,378
Ensembl chr11:50,127,288...50,129,443
JBrowse link
G Lum lumican decreases expression ISO diethyl maleate results in decreased expression of LUM mRNA CTD PMID:21161181 NCBI chr10:97,401,363...97,408,565
Ensembl chr10:97,400,990...97,408,565
JBrowse link
G Maff v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) increases expression ISO diethyl maleate results in increased expression of MAFF mRNA CTD PMID:20491607 PMID:33545341 NCBI chr15:79,230,813...79,243,278
Ensembl chr15:79,230,821...79,243,276
JBrowse link
G Mafg v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian) increases expression ISO diethyl maleate results in increased expression of MAFG mRNA CTD PMID:33545341 PMID:34480604 NCBI chr11:120,515,943...120,525,771
Ensembl chr11:120,515,943...120,524,426
JBrowse link
G Maoa monoamine oxidase A increases expression EXP diethyl maleate results in increased expression of MAOA mRNA CTD PMID:25270620 NCBI chr  X:16,485,937...16,554,051
Ensembl chr  X:16,485,937...16,554,057
JBrowse link
G Mapk1ip1l mitogen-activated protein kinase 1 interacting protein 1-like increases expression ISO diethyl maleate results in increased expression of MAPK1IP1L mRNA CTD PMID:33545341 NCBI chr14:47,535,731...47,560,663
Ensembl chr14:47,535,723...47,560,661
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression
multiple interactions
ISO diethyl maleate results in increased expression of MAPK8 protein modified form
pyrazolanthrone inhibits the reaction [diethyl maleate results in increased expression of MAPK8 protein modified form]
CTD PMID:30261343 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases expression
multiple interactions
ISO diethyl maleate results in increased expression of MAPK9 protein modified form
pyrazolanthrone inhibits the reaction [diethyl maleate results in increased expression of MAPK9 protein modified form]
CTD PMID:30261343 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248
JBrowse link
G Marveld1 MARVEL (membrane-associating) domain containing 1 decreases expression ISO diethyl maleate results in decreased expression of MARVELD1 mRNA CTD PMID:21161181 NCBI chr19:42,135,879...42,140,137
Ensembl chr19:42,135,839...42,140,142
JBrowse link
G Mboat7 membrane bound O-acyltransferase domain containing 7 increases expression ISO diethyl maleate results in increased expression of MBOAT7 mRNA CTD PMID:33545341 NCBI chr 7:3,680,788...3,696,188
Ensembl chr 7:3,680,788...3,696,522
JBrowse link
G Mcm10 minichromosome maintenance 10 replication initiation factor increases expression ISO diethyl maleate results in increased expression of MCM10 mRNA CTD PMID:21161181 NCBI chr 2:4,995,535...5,017,602
Ensembl chr 2:4,994,525...5,017,602
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 increases expression ISO diethyl maleate results in increased expression of MCM4 mRNA CTD PMID:21161181 NCBI chr16:15,441,761...15,455,264
Ensembl chr16:15,441,761...15,455,264
JBrowse link
G Me1 malic enzyme 1, NADP(+)-dependent, cytosolic increases expression EXP diethyl maleate results in increased expression of ME1 mRNA CTD PMID:25270620 NCBI chr 9:86,463,416...86,577,967
Ensembl chr 9:86,463,424...86,578,006
JBrowse link
G Mfap4 microfibrillar-associated protein 4 decreases expression ISO diethyl maleate results in decreased expression of MFAP4 mRNA CTD PMID:21161181 NCBI chr11:61,376,257...61,379,536
Ensembl chr11:61,376,257...61,379,726
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases activity ISO diethyl maleate results in decreased activity of MGMT protein CTD PMID:16950796 NCBI chr 7:136,496,315...136,732,001
Ensembl chr 7:136,496,343...136,731,995
JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 increases expression ISO diethyl maleate results in increased expression of MKI67 mRNA CTD PMID:21161181 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090
JBrowse link
G Mknk2 MAP kinase-interacting serine/threonine kinase 2 decreases expression ISO diethyl maleate results in decreased expression of MKNK2 mRNA CTD PMID:21161181 NCBI chr10:80,501,152...80,512,264
Ensembl chr10:80,501,161...80,513,946
JBrowse link
G Mmp12 matrix metallopeptidase 12 increases expression EXP diethyl maleate results in increased expression of MMP12 mRNA CTD PMID:10216232 NCBI chr 9:7,344,397...7,360,461
Ensembl chr 9:7,344,381...7,369,499
JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) increases expression ISO diethyl maleate results in increased expression of MMP1 mRNA CTD PMID:33545341 NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO diethyl maleate results in decreased expression of MMP2 mRNA CTD PMID:21161181 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO diethyl maleate results in increased expression of MMP3 mRNA CTD PMID:33545341 NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975
JBrowse link
G Mpzl1 myelin protein zero-like 1 decreases expression ISO diethyl maleate results in decreased expression of MPZL1 mRNA CTD PMID:34480604 NCBI chr 1:165,419,745...165,462,144
Ensembl chr 1:165,419,809...165,462,107
JBrowse link
G Msn moesin increases reduction EXP diethyl maleate results in increased reduction of MSN protein CTD PMID:19843705 NCBI chr  X:95,139,651...95,212,159
Ensembl chr  X:95,139,648...95,212,158
JBrowse link
G Mt2 metallothionein 2 increases expression ISO diethyl maleate results in increased expression of MT2A mRNA CTD PMID:20491607 NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196
JBrowse link
G Mx1 MX dynamin-like GTPase 1 decreases expression ISO diethyl maleate results in decreased expression of MX1 mRNA CTD PMID:21161181 NCBI chr16:97,248,235...97,264,106
Ensembl chr16:97,248,235...97,264,107
JBrowse link
G Mybl2 myeloblastosis oncogene-like 2 increases expression ISO diethyl maleate results in increased expression of MYBL2 mRNA CTD PMID:21161181 NCBI chr 2:162,896,246...162,926,608
Ensembl chr 2:162,896,607...162,926,608
JBrowse link
G Mycn v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived decreases expression EXP diethyl maleate results in decreased expression of MYCN mRNA CTD PMID:25270620 NCBI chr12:12,986,094...12,991,837
Ensembl chr12:12,986,094...12,991,915
JBrowse link
G Nat8 N-acetyltransferase 8 (GCN5-related) decreases expression ISO diethyl maleate results in decreased expression of NAT8 mRNA CTD PMID:21161181 NCBI chr 6:85,807,369...85,813,839
Ensembl chr 6:85,807,370...85,809,064
JBrowse link
G Ncaph non-SMC condensin I complex, subunit H increases expression ISO diethyl maleate results in increased expression of NCAPH mRNA CTD PMID:21161181 NCBI chr 2:126,945,729...126,975,857
Ensembl chr 2:126,945,729...126,975,874
JBrowse link
G Ndrg1 N-myc downstream regulated gene 1 increases expression ISO diethyl maleate results in increased expression of NDRG1 mRNA CTD PMID:33545341 NCBI chr15:66,801,167...66,841,490
Ensembl chr15:66,801,167...66,841,489
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 affects localization
increases activity
increases expression
multiple interactions
decreases response to substance
EXP
ISO
diethyl maleate affects the localization of NFE2L2 protein
diethyl maleate results in increased activity of NFE2L2 protein
diethyl maleate results in increased expression of NFE2L2 protein
[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein; diethyl maleate binds to and results in increased activity of NFE2L2 protein; diethyl maleate promotes the reaction [NFE2L2 protein binds to SMPD1 promoter]; diethyl maleate results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SMPD1 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]; NFE2L2 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; NFE2L2 protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; NFE2L2 protein promotes the reaction [diethyl maleate results in increased expression of SRXN1 protein]; RELA protein inhibits the reaction [diethyl maleate results in increased expression of NFE2L2 protein]; RELA protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein]; TNFAIP3 protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein]
NFE2L2 results in decreased susceptibility to diethyl maleate
NFE2L2 gene mutant form inhibits the reaction [diethyl maleate results in increased expression of SLC7A11 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 mRNA]
CTD PMID:12235164 PMID:20806931 PMID:21465251 PMID:22003191 PMID:25762726 More... NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP
ISO
diethyl maleate inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]
diethyl maleate inhibits the reaction [IL1B protein affects the localization of NFKBIA protein]; diethyl maleate inhibits the reaction [TNF protein affects the localization of NFKBIA protein]
CTD PMID:12774022 PMID:35724838 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
JBrowse link
G Nherf1 NHERF family PDZ scaffold protein 1 decreases expression ISO diethyl maleate results in decreased expression of NHERF1 mRNA CTD PMID:21161181 NCBI chr11:115,054,138...115,072,009
Ensembl chr11:115,054,167...115,072,007
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP
ISO
diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]
Acetylcysteine inhibits the reaction [diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of diethyl maleate]
CTD PMID:7532384 PMID:9918918 PMID:12774022 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Notch1 notch 1 increases expression ISO diethyl maleate results in increased expression of NOTCH1 mRNA CTD PMID:33545341 NCBI chr 2:26,347,914...26,393,834
Ensembl chr 2:26,347,915...26,406,675
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression ISO
EXP
diethyl maleate results in increased expression of NQO1 mRNA CTD PMID:20491607 PMID:25270620 PMID:33545341 PMID:34480604 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression ISO diethyl maleate results in decreased expression of NR0B2 mRNA CTD PMID:21161181 NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 decreases expression ISO diethyl maleate results in decreased expression of NR1D1 mRNA CTD PMID:21161181 NCBI chr11:98,658,758...98,666,233
Ensembl chr11:98,658,758...98,666,159
JBrowse link
G Nrep neuronal regeneration related protein decreases expression ISO diethyl maleate results in decreased expression of NREP mRNA CTD PMID:21161181 NCBI chr18:33,570,072...33,597,444
Ensembl chr18:33,570,072...33,597,082
JBrowse link
G Nsmf NMDA receptor synaptonuclear signaling and neuronal migration factor decreases expression EXP diethyl maleate results in decreased expression of NSMF mRNA CTD PMID:25270620 NCBI chr 2:24,944,370...24,952,893
Ensembl chr 2:24,944,367...24,952,893
JBrowse link
G Ntf3 neurotrophin 3 decreases expression ISO diethyl maleate results in decreased expression of NTF3 mRNA CTD PMID:21161181 NCBI chr 6:126,078,375...126,143,703
Ensembl chr 6:126,078,375...126,143,873
JBrowse link
G Nup153 nucleoporin 153 multiple interactions
affects localization
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP153 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP153 protein]; diethyl maleate results in increased phosphorylation of and results in increased O-linked glycosylation of NUP153 protein CTD PMID:20041180 NCBI chr13:46,833,369...46,890,682
Ensembl chr13:46,833,381...46,881,416
JBrowse link
G Nup88 nucleoporin 88 multiple interactions
affects localization
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP88 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP88 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] affects the reaction [diethyl maleate affects the localization of NUP88 protein]; diethyl maleate results in increased phosphorylation of and results in increased glycosylation of NUP88 protein CTD PMID:20041180 NCBI chr11:70,833,884...70,860,799
Ensembl chr11:70,833,884...70,860,799
JBrowse link
G Oaf out at first homolog decreases expression ISO diethyl maleate results in decreased expression of OAF mRNA CTD PMID:21161181 NCBI chr 9:43,132,575...43,151,113
Ensembl chr 9:43,132,532...43,151,208
JBrowse link
G Oas1g 2'-5' oligoadenylate synthetase 1G decreases expression ISO diethyl maleate results in decreased expression of OAS1A mRNA CTD PMID:21161181 NCBI chr 5:121,014,205...121,025,676
Ensembl chr 5:121,014,205...121,025,676
JBrowse link
G Ogg1 8-oxoguanine DNA-glycosylase 1 multiple interactions EXP [diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of OGG1 mRNA CTD PMID:22564015 NCBI chr 6:113,303,959...113,311,149
Ensembl chr 6:113,303,933...113,312,029
JBrowse link
G Orc1 origin recognition complex, subunit 1 increases expression ISO diethyl maleate results in increased expression of ORC1 mRNA CTD PMID:21161181 NCBI chr 4:108,436,651...108,472,030
Ensembl chr 4:108,436,620...108,472,030
JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 increases expression ISO diethyl maleate results in increased expression of OSGIN1 mRNA CTD PMID:33545341 NCBI chr 8:120,160,874...120,172,996
Ensembl chr 8:120,160,863...120,172,995
JBrowse link
G P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 decreases expression ISO diethyl maleate results in decreased expression of P2RX7 mRNA CTD PMID:21161181 NCBI chr 5:122,781,990...122,830,399
Ensembl chr 5:122,781,974...122,829,495
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO diethyl maleate results in increased cleavage of PARP1 protein CTD PMID:21105742 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Pbld1 phenazine biosynthesis-like protein domain containing 1 decreases expression ISO diethyl maleate results in decreased expression of PBLD protein CTD PMID:21161181 NCBI chr10:62,896,404...62,913,743
Ensembl chr10:62,895,941...62,913,741
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO diethyl maleate results in decreased expression of PCNA mRNA CTD PMID:11875189 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
JBrowse link
G Pdlim2 PDZ and LIM domain 2 decreases expression ISO diethyl maleate results in decreased expression of PDLIM2 mRNA CTD PMID:21161181 NCBI chr14:70,401,667...70,415,140
Ensembl chr14:70,401,667...70,415,130
JBrowse link
G Pdrg1 p53 and DNA damage regulated 1 increases expression EXP diethyl maleate results in increased expression of PDRG1 mRNA CTD PMID:25270620 NCBI chr 2:152,850,810...152,857,939
Ensembl chr 2:152,850,810...152,857,347
JBrowse link
G Per2 period circadian clock 2 decreases expression ISO diethyl maleate results in decreased expression of PER2 mRNA CTD PMID:21161181 NCBI chr 1:91,343,699...91,387,028
Ensembl chr 1:91,343,704...91,387,046
JBrowse link
G Per3 period circadian clock 3 decreases expression ISO diethyl maleate results in decreased expression of PER3 mRNA CTD PMID:21161181 NCBI chr 4:151,081,475...151,129,167
Ensembl chr 4:151,088,109...151,129,122
JBrowse link
G Pgd phosphogluconate dehydrogenase increases activity ISO diethyl maleate results in increased activity of PGD protein CTD PMID:3099627 NCBI chr 4:149,234,448...149,251,162
Ensembl chr 4:149,234,448...149,251,228
JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 increases expression EXP diethyl maleate results in increased expression of PGRMC1 mRNA CTD PMID:25270620 NCBI chr  X:35,861,846...35,869,732
Ensembl chr  X:35,861,859...35,869,732
JBrowse link
G Pir pirin increases expression EXP diethyl maleate results in increased expression of PIR mRNA CTD PMID:25270620 NCBI chr  X:163,052,427...163,156,009
Ensembl chr  X:163,052,367...163,156,007
JBrowse link
G Pklr pyruvate kinase liver and red blood cell decreases expression ISO diethyl maleate results in decreased expression of PKLR mRNA CTD PMID:21161181 NCBI chr 3:89,043,429...89,054,122
Ensembl chr 3:89,043,449...89,054,091
JBrowse link
G Plat plasminogen activator, tissue increases expression
decreases expression
ISO
EXP
diethyl maleate results in increased expression of PLAT mRNA
diethyl maleate results in decreased expression of PLAT mRNA
CTD PMID:21161181 PMID:25270620 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860
JBrowse link
G Plek pleckstrin decreases expression ISO diethyl maleate results in decreased expression of PLEK mRNA CTD PMID:21161181 NCBI chr11:16,921,206...16,958,718
Ensembl chr11:16,921,206...17,002,381
JBrowse link
G Plekhm1 pleckstrin homology domain containing, family M (with RUN domain) member 1 increases expression ISO diethyl maleate results in increased expression of PLEKHM1 mRNA CTD PMID:33545341 NCBI chr11:103,255,101...103,303,531
Ensembl chr11:103,255,101...103,303,513
JBrowse link
G Plin2 perilipin 2 increases expression ISO diethyl maleate results in increased expression of PLIN2 mRNA CTD PMID:33545341 NCBI chr 4:86,545,147...86,588,518
Ensembl chr 4:86,566,623...86,588,297
JBrowse link
G Plk1 polo like kinase 1 increases expression ISO diethyl maleate results in increased expression of PLK1 mRNA CTD PMID:33545341 NCBI chr 7:121,758,658...121,769,107
Ensembl chr 7:121,758,662...121,769,096
JBrowse link
G Plk3 polo like kinase 3 increases expression ISO diethyl maleate results in increased expression of PLK3 mRNA CTD PMID:33545341 NCBI chr 4:116,985,852...116,991,244
Ensembl chr 4:116,985,852...116,991,160
JBrowse link
G Pou5f1 POU domain, class 5, transcription factor 1 increases expression ISO diethyl maleate results in increased expression of POU5F1 mRNA CTD PMID:33545341 NCBI chr17:35,816,929...35,821,674
Ensembl chr17:35,816,915...35,821,669
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
decreases activity
ISO diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]; resveratrol inhibits the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol inhibits the reaction [diethyl maleate results in decreased activity of PPARA protein]; resveratrol promotes the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol promotes the reaction [diethyl maleate results in decreased activity of PPARA protein] CTD PMID:17134953 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
JBrowse link
G Ppargc1b peroxisome proliferative activated receptor, gamma, coactivator 1 beta decreases expression ISO diethyl maleate results in decreased expression of PPARGC1B mRNA CTD PMID:21161181 NCBI chr18:61,424,516...61,533,846
Ensembl chr18:61,431,207...61,533,502
JBrowse link
G Ppp1r3b protein phosphatase 1, regulatory subunit 3B decreases expression ISO diethyl maleate results in decreased expression of PPP1R3B mRNA CTD PMID:21161181 NCBI chr 8:35,842,847...35,855,293
Ensembl chr 8:35,842,893...35,855,293
JBrowse link
G Ppp1r3c protein phosphatase 1, regulatory subunit 3C decreases expression ISO diethyl maleate results in decreased expression of PPP1R3C mRNA CTD PMID:21161181 NCBI chr19:36,709,131...36,714,004
Ensembl chr19:36,709,131...36,714,053
JBrowse link
G Prdm14 PR domain containing 14 decreases expression EXP diethyl maleate results in decreased expression of PRDM14 mRNA CTD PMID:25270620 NCBI chr 1:13,183,649...13,197,467
Ensembl chr 1:13,183,681...13,197,387
JBrowse link
G Prdx1 peroxiredoxin 1 increases expression EXP
ISO
diethyl maleate results in increased expression of PRDX1 mRNA CTD PMID:9506838 NCBI chr 4:116,542,796...116,557,196
Ensembl chr 4:116,542,741...116,558,019
JBrowse link
G Prkab1 protein kinase, AMP-activated, beta 1 non-catalytic subunit decreases expression EXP diethyl maleate results in decreased expression of PRKAB1 mRNA CTD PMID:25270620 NCBI chr 5:116,151,654...116,162,449
Ensembl chr 5:116,151,645...116,162,567
JBrowse link
G Prkag2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit increases expression ISO diethyl maleate results in increased expression of PRKAG2 mRNA CTD PMID:33545341 NCBI chr 5:25,067,733...25,311,576
Ensembl chr 5:25,067,742...25,305,640
JBrowse link
G Prkcb protein kinase C, beta affects expression ISO diethyl maleate affects the expression of PRKCB protein CTD PMID:31958493 NCBI chr 7:121,888,327...122,233,625
Ensembl chr 7:121,887,974...122,233,625
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO Cycloheximide inhibits the reaction [diethyl maleate results in increased expression of PRKCD protein]; diethyl maleate results in increased expression of and results in increased activity of PRKCD protein CTD PMID:11118818 NCBI chr14:30,317,310...30,348,637
Ensembl chr14:30,317,311...30,348,167
JBrowse link
G Prkce protein kinase C, epsilon multiple interactions ISO Cycloheximide inhibits the reaction [diethyl maleate results in increased expression of PRKCE protein]; diethyl maleate results in increased expression of and results in increased activity of PRKCE protein CTD PMID:11118818 NCBI chr17:86,472,631...86,965,347
Ensembl chr17:86,475,213...86,965,347
JBrowse link
G Prss8 serine protease 8 (prostasin) decreases expression ISO diethyl maleate results in decreased expression of PRSS8 mRNA CTD PMID:21161181 NCBI chr 7:127,524,889...127,529,266
Ensembl chr 7:127,524,888...127,529,276
JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression EXP diethyl maleate results in increased expression of PTGR1 mRNA CTD PMID:25270620 NCBI chr 4:58,965,590...58,987,131
Ensembl chr 4:58,965,439...58,987,119
JBrowse link
G Ptpn14 protein tyrosine phosphatase, non-receptor type 14 increases expression EXP diethyl maleate results in increased expression of PTPN14 mRNA CTD PMID:25270620 NCBI chr 1:189,460,417...189,608,892
Ensembl chr 1:189,460,465...189,608,892
JBrowse link
G Pus1 pseudouridine synthase 1 decreases expression EXP diethyl maleate results in decreased expression of PUS1 mRNA CTD PMID:25270620 NCBI chr 5:110,921,533...110,928,523
Ensembl chr 5:110,921,533...110,928,525
JBrowse link
G Pxn paxillin increases expression ISO diethyl maleate results in increased expression of PXN mRNA CTD PMID:33545341 NCBI chr 5:115,630,035...115,694,046
Ensembl chr 5:115,644,735...115,694,046
JBrowse link
G Rab27a RAB27A, member RAS oncogene family decreases expression ISO diethyl maleate results in decreased expression of RAB27A mRNA CTD PMID:21161181 NCBI chr 9:72,952,092...73,004,905
Ensembl chr 9:72,952,136...73,004,911
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO diethyl maleate inhibits the reaction [[carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein]; diethyl maleate inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; diethyl maleate inhibits the reaction [IL1B protein affects the localization of RELA protein]; diethyl maleate inhibits the reaction [TNF protein affects the localization of RELA protein]; RELA protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; RELA protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; RELA protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]]; RELA protein inhibits the reaction [diethyl maleate results in increased expression of NFE2L2 protein]; RELA protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein]; RELA protein promotes the reaction [diethyl maleate results in increased expression of SRXN1 protein] CTD PMID:20116392 PMID:35724838 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Rho rhodopsin increases expression ISO diethyl maleate results in increased expression of RHO mRNA CTD PMID:33545341 NCBI chr 6:115,903,741...115,916,999
Ensembl chr 6:115,908,709...115,916,997
JBrowse link
G Rnf114 ring finger protein 114 decreases expression EXP diethyl maleate results in decreased expression of RNF114 mRNA CTD PMID:25270620 NCBI chr 2:167,334,565...167,358,093
Ensembl chr 2:167,334,565...167,358,093
JBrowse link
G Rnf14 ring finger protein 14 increases expression EXP diethyl maleate results in increased expression of RNF14 mRNA CTD PMID:25270620 NCBI chr18:38,410,513...38,450,905
Ensembl chr18:38,417,590...38,450,902
JBrowse link
G Rrm2 ribonucleotide reductase M2 increases expression ISO diethyl maleate results in increased expression of RRM2 mRNA CTD PMID:21161181 PMID:33545341 NCBI chr12:24,758,253...24,764,145
Ensembl chr12:24,758,240...24,764,145
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 decreases expression ISO diethyl maleate results in decreased expression of RSAD2 mRNA CTD PMID:21161181 NCBI chr12:26,492,742...26,506,451
Ensembl chr12:26,492,745...26,506,451
JBrowse link
G S100a9 S100 calcium binding protein A9 (calgranulin B) decreases expression ISO diethyl maleate results in decreased expression of S100A9 mRNA CTD PMID:21161181 NCBI chr 3:90,599,937...90,603,028
Ensembl chr 3:90,599,939...90,603,028
JBrowse link
G Sash3 SAM and SH3 domain containing 3 decreases expression ISO diethyl maleate results in decreased expression of SASH3 mRNA CTD PMID:21161181 NCBI chr  X:47,235,313...47,250,442
Ensembl chr  X:47,235,313...47,250,442
JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression ISO diethyl maleate results in decreased expression of SCARB1 mRNA CTD PMID:34480604 NCBI chr 5:125,354,151...125,418,082
Ensembl chr 5:125,354,151...125,418,158
JBrowse link
G Scd1 stearoyl-Coenzyme A desaturase 1 decreases expression ISO diethyl maleate results in decreased expression of SCD1 mRNA CTD PMID:21161181 NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318
JBrowse link
G Sds serine dehydratase decreases expression ISO diethyl maleate results in decreased expression of SDS mRNA CTD PMID:21161181 NCBI chr 5:120,614,612...120,621,997
Ensembl chr 5:120,614,591...120,621,997
JBrowse link
G Selenop selenoprotein P decreases expression ISO diethyl maleate results in decreased expression of SELENOP mRNA CTD PMID:30261343 NCBI chr15:3,300,249...3,309,992
Ensembl chr15:3,298,029...3,309,990
JBrowse link
G Serpinb6b serine (or cysteine) peptidase inhibitor, clade B, member 6b decreases expression EXP diethyl maleate results in decreased expression of SERPINB6B mRNA CTD PMID:25270620 NCBI chr13:33,140,797...33,163,050
Ensembl chr13:33,149,192...33,163,050
JBrowse link
G Serpind1 serine (or cysteine) peptidase inhibitor, clade D, member 1 decreases expression EXP diethyl maleate results in decreased expression of SERPIND1 mRNA CTD PMID:25270620 NCBI chr16:17,149,235...17,161,438
Ensembl chr16:17,149,235...17,161,439
JBrowse link
G Sertad1 SERTA domain containing 1 increases expression ISO diethyl maleate results in increased expression of SERTAD1 mRNA CTD PMID:33545341 NCBI chr 7:27,186,378...27,189,741
Ensembl chr 7:27,186,335...27,189,741
JBrowse link
G Sez6 seizure related gene 6 decreases expression ISO diethyl maleate results in decreased expression of SEZ6 mRNA CTD PMID:21161181 NCBI chr11:77,821,403...77,869,874
Ensembl chr11:77,821,626...77,869,874
JBrowse link
G Sfxn1 sideroflexin 1 decreases expression EXP diethyl maleate results in decreased expression of SFXN1 mRNA CTD PMID:25270620 NCBI chr13:54,225,675...54,262,365
Ensembl chr13:54,225,888...54,262,361
JBrowse link
G Sh3bp5 SH3-domain binding protein 5 (BTK-associated) increases expression
affects expression
ISO diethyl maleate results in increased expression of SH3BP5 mRNA
diethyl maleate affects the expression of SH3BP5 mRNA
CTD PMID:33545341 PMID:34480604 NCBI chr14:31,094,571...31,158,056
Ensembl chr14:31,081,837...31,158,035
JBrowse link
G Six4 sine oculis-related homeobox 4 increases expression EXP diethyl maleate results in increased expression of SIX4 mRNA CTD PMID:25270620 NCBI chr12:73,146,383...73,160,201
Ensembl chr12:73,146,383...73,160,230
JBrowse link
G Slc16a6 solute carrier family 16 (monocarboxylic acid transporters), member 6 decreases expression EXP diethyl maleate results in decreased expression of SLC16A6 mRNA CTD PMID:25270620 NCBI chr11:109,341,681...109,366,428
Ensembl chr11:109,341,681...109,364,424
JBrowse link
G Slc1a4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 increases expression EXP diethyl maleate results in increased expression of SLC1A4 mRNA CTD PMID:25270620 NCBI chr11:20,252,180...20,282,713
Ensembl chr11:20,252,180...20,282,713
JBrowse link
G Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 decreases expression ISO diethyl maleate results in decreased expression of SLC2A2 mRNA CTD PMID:21161181 NCBI chr 3:28,752,052...28,782,510
Ensembl chr 3:28,752,052...28,785,508
JBrowse link
G Slc2a5 solute carrier family 2 (facilitated glucose transporter), member 5 decreases expression ISO diethyl maleate results in decreased expression of SLC2A5 mRNA CTD PMID:21161181 NCBI chr 4:150,203,801...150,228,625
Ensembl chr 4:150,203,740...150,228,626
JBrowse link
G Slc39a14 solute carrier family 39 (zinc transporter), member 14 decreases expression EXP diethyl maleate results in decreased expression of SLC39A14 mRNA CTD PMID:25270620 NCBI chr14:70,540,916...70,588,873
Ensembl chr14:70,540,918...70,588,874
JBrowse link
G Slc3a2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 increases expression ISO diethyl maleate results in increased expression of SLC3A2 mRNA CTD PMID:33545341 NCBI chr19:8,684,931...8,700,733
Ensembl chr19:8,684,246...8,700,733
JBrowse link
G Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 multiple interactions ISO diethyl maleate inhibits the reaction [Lipopolysaccharides results in decreased expression of SLC40A1 mRNA] CTD PMID:21303654 NCBI chr 1:45,947,230...45,965,690
Ensembl chr 1:45,947,228...45,965,683
JBrowse link
G Slc44a4 solute carrier family 44, member 4 decreases expression ISO diethyl maleate results in decreased expression of SLC44A4 mRNA CTD PMID:21161181 NCBI chr17:35,133,200...35,149,412
Ensembl chr17:35,133,442...35,149,412
JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 multiple interactions
increases expression
EXP
ISO
NFE2L2 gene mutant form inhibits the reaction [diethyl maleate results in increased expression of SLC7A11 mRNA] CTD PMID:12235164 PMID:33545341 NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063
JBrowse link
G Slco2a1 solute carrier organic anion transporter family, member 2a1 decreases expression ISO diethyl maleate results in decreased expression of SLCO2A1 mRNA CTD PMID:21161181 NCBI chr 9:102,885,686...102,973,201
Ensembl chr 9:102,865,911...102,973,201
JBrowse link
G Slfn3 schlafen 3 decreases expression ISO diethyl maleate results in decreased expression of SLFN3 mRNA CTD PMID:21161181 NCBI chr11:83,082,156...83,105,980
Ensembl chr11:83,082,156...83,105,980
JBrowse link
G Smc4 structural maintenance of chromosomes 4 increases expression ISO diethyl maleate results in increased expression of SMC4 mRNA CTD PMID:21161181 NCBI chr 3:68,912,071...68,941,956
Ensembl chr 3:68,912,071...68,941,956
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1, acid lysosomal increases expression
multiple interactions
increases activity
ISO diethyl maleate results in increased expression of SMPD1 mRNA
Dactinomycin inhibits the reaction [diethyl maleate results in increased expression of SMPD1 mRNA]; diethyl maleate promotes the reaction [NFE2L2 protein binds to SMPD1 promoter]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SMPD1 mRNA]
diethyl maleate results in increased activity of SMPD1 protein
CTD PMID:25762726 NCBI chr 7:105,203,567...105,207,596
Ensembl chr 7:105,203,567...105,207,596
JBrowse link
G Smtn smoothelin increases expression ISO diethyl maleate results in increased expression of SMTN mRNA CTD PMID:21161181 NCBI chr11:3,467,522...3,489,337
Ensembl chr11:3,467,521...3,490,612
JBrowse link
G Socs3 suppressor of cytokine signaling 3 decreases expression EXP diethyl maleate results in decreased expression of SOCS3 mRNA CTD PMID:25270620 NCBI chr11:117,856,905...117,860,192
Ensembl chr11:117,856,905...117,860,873
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions ISO diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Sorl1 sortilin-related receptor, LDLR class A repeats-containing decreases expression ISO diethyl maleate results in decreased expression of SORL1 mRNA CTD PMID:21161181 NCBI chr 9:41,876,005...42,035,593
Ensembl chr 9:41,876,016...42,035,593
JBrowse link
G Sox9 SRY (sex determining region Y)-box 9 increases expression ISO diethyl maleate results in increased expression of SOX9 mRNA CTD PMID:21161181 NCBI chr11:112,673,036...112,678,583
Ensembl chr11:112,673,050...112,678,586
JBrowse link
G Sp5 trans-acting transcription factor 5 decreases expression EXP diethyl maleate results in decreased expression of SP5 mRNA CTD PMID:25270620 NCBI chr 2:70,305,267...70,308,070
Ensembl chr 2:70,305,267...70,308,073
JBrowse link
G Spc25 SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) increases expression ISO diethyl maleate results in increased expression of SPC25 mRNA CTD PMID:21161181 NCBI chr 2:69,009,753...69,036,583
Ensembl chr 2:69,024,239...69,036,538
JBrowse link
G Spta1 spectrin alpha, erythrocytic 1 increases expression EXP diethyl maleate results in increased expression of SPTA1 mRNA CTD PMID:25270620 NCBI chr 1:174,000,305...174,076,015
Ensembl chr 1:174,000,342...174,076,016
JBrowse link
G Sptan1 spectrin alpha, non-erythrocytic 1 increases cleavage ISO diethyl maleate results in increased cleavage of SPTAN1 protein CTD PMID:21105742 NCBI chr 2:29,855,572...29,921,463
Ensembl chr 2:29,855,572...29,921,463
JBrowse link
G Sptbn4 spectrin beta, non-erythrocytic 4 increases expression EXP diethyl maleate results in increased expression of SPTBN4 mRNA CTD PMID:25270620 NCBI chr 7:27,055,808...27,147,128
Ensembl chr 7:27,055,808...27,147,111
JBrowse link
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 increases expression ISO diethyl maleate results in increased expression of SPTLC1 mRNA CTD PMID:33545341 NCBI chr13:53,486,784...53,531,401
Ensembl chr13:53,486,784...53,531,433
JBrowse link
G Sqstm1 sequestosome 1 increases expression EXP
ISO
diethyl maleate results in increased expression of SQSTM1 mRNA CTD PMID:25270620 PMID:33545341 PMID:34480604 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression ISO diethyl maleate results in decreased expression of SREBF1 mRNA CTD PMID:21161181 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407
JBrowse link
G Srxn1 sulfiredoxin 1 homolog (S. cerevisiae) multiple interactions
decreases expression
increases expression
EXP
ISO
[Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [diethyl maleate results in increased expression of SRXN1 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 mRNA]
diethyl maleate results in decreased expression of SRXN1 mRNA
[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]; NFE2L2 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; NFE2L2 protein promotes the reaction [diethyl maleate results in increased expression of SRXN1 protein]; RELA protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; RELA protein promotes the reaction [diethyl maleate results in increased expression of SRXN1 protein]; TNFAIP3 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; TP53 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]
diethyl maleate results in increased expression of SRXN1 mRNA; diethyl maleate results in increased expression of SRXN1 protein
CTD PMID:22003191 PMID:25270620 PMID:27358234 PMID:27982581 PMID:33545341 More... NCBI chr 2:151,946,738...151,953,296
Ensembl chr 2:151,947,436...151,953,296
JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression ISO diethyl maleate results in decreased expression of STAT1 mRNA CTD PMID:21161181 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024
JBrowse link
G Steap4 STEAP family member 4 decreases expression EXP diethyl maleate results in decreased expression of STEAP4 mRNA CTD PMID:25270620 NCBI chr 5:8,010,472...8,032,213
Ensembl chr 5:8,010,457...8,032,213
JBrowse link
G Sulf2 sulfatase 2 decreases expression ISO diethyl maleate results in decreased expression of SULF2 mRNA CTD PMID:21161181 NCBI chr 2:165,915,819...165,997,603
Ensembl chr 2:165,915,009...165,997,583
JBrowse link
G Tagln transgelin decreases expression ISO diethyl maleate results in decreased expression of TAGLN mRNA CTD PMID:21161181 NCBI chr 9:45,840,926...45,847,356
Ensembl chr 9:45,840,917...45,847,356
JBrowse link
G Tatdn2 TatD DNase domain containing 2 increases expression ISO diethyl maleate results in increased expression of TATDN2 mRNA CTD PMID:33545341 NCBI chr 6:113,674,090...113,688,030
Ensembl chr 6:113,674,011...113,688,030
JBrowse link
G Tbcel tubulin folding cofactor E-like increases expression EXP diethyl maleate results in increased expression of TBCEL mRNA CTD PMID:25270620 NCBI chr 9:42,323,612...42,383,534
Ensembl chr 9:42,323,612...42,419,105
JBrowse link
G Tent4a terminal nucleotidyltransferase 4A increases expression ISO diethyl maleate results in increased expression of TENT4A mRNA CTD PMID:33545341 NCBI chr13:69,646,071...69,682,710
Ensembl chr13:69,646,078...69,682,736
JBrowse link
G Tent5a terminal nucleotidyltransferase 5A decreases expression ISO diethyl maleate results in decreased expression of TENT5A mRNA CTD PMID:21161181 NCBI chr 9:85,202,492...85,209,203
Ensembl chr 9:85,202,492...85,209,401
JBrowse link
G Tesmin testis expressed metallothionein like affects localization EXP diethyl maleate affects the localization of TESMIN protein CTD PMID:12606435 NCBI chr19:3,438,857...3,457,823
Ensembl chr19:3,438,857...3,457,823
JBrowse link
G Tfeb transcription factor EB decreases expression EXP diethyl maleate results in decreased expression of TFEB mRNA CTD PMID:25270620 NCBI chr17:48,047,962...48,103,341
Ensembl chr17:48,047,955...48,103,344
JBrowse link
G Tgm2 transglutaminase 2, C polypeptide increases expression ISO diethyl maleate results in increased expression of TGM2 mRNA CTD PMID:21161181 NCBI chr 2:157,958,325...157,988,312
Ensembl chr 2:157,958,322...157,988,356
JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO diethyl maleate results in increased expression of THBS1 mRNA CTD PMID:21161181 NCBI chr 2:117,942,357...117,957,614
Ensembl chr 2:117,942,357...117,957,614
JBrowse link
G Thrsp thyroid hormone responsive decreases expression ISO diethyl maleate results in decreased expression of THRSP mRNA CTD PMID:21161181 NCBI chr 7:97,062,140...97,066,757
Ensembl chr 7:97,062,145...97,066,937
JBrowse link
G Tm4sf1 transmembrane 4 superfamily member 1 increases expression ISO diethyl maleate results in increased expression of TM4SF1 mRNA CTD PMID:21161181 NCBI chr 3:57,193,038...57,295,150
Ensembl chr 3:57,193,032...57,209,409
Ensembl chr 3:57,193,032...57,209,409
JBrowse link
G Tmem209 transmembrane protein 209 increases expression EXP diethyl maleate results in increased expression of TMEM209 mRNA CTD PMID:25270620 NCBI chr 6:30,480,806...30,509,786
Ensembl chr 6:30,479,052...30,509,782
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
[diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein; [diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein; [diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein; diethyl maleate inhibits the reaction [[carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein]; diethyl maleate inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; diethyl maleate inhibits the reaction [TNF protein affects the localization of NFKBIA protein]; diethyl maleate inhibits the reaction [TNF protein affects the localization of RELA protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; NFE2L2 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; NFE2L2 protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; RELA protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; RELA protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; RELA protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]]; RELA protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein]; TNFAIP3 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; TNFAIP3 protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein]
diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of diethyl maleate]
diethyl maleate inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]]; TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]
CTD PMID:7476933 PMID:7532384 PMID:12774022 PMID:20116392 PMID:31958493 More... NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tnfaip3 tumor necrosis factor, alpha-induced protein 3 multiple interactions ISO diethyl maleate inhibits the reaction [IL1B protein results in increased expression of TNFAIP3 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; RELA protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]]; TNFAIP3 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; TNFAIP3 protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein] CTD PMID:35724838 NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405
JBrowse link
G Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) decreases expression ISO diethyl maleate results in decreased expression of TNFRSF14 mRNA CTD PMID:21161181 NCBI chr 4:155,002,944...155,013,077
Ensembl chr 4:155,006,390...155,013,020
JBrowse link
G Tpm2 tropomyosin 2, beta decreases expression ISO diethyl maleate results in decreased expression of TPM2 mRNA CTD PMID:21161181 NCBI chr 4:43,513,726...43,523,583
Ensembl chr 4:43,514,711...43,523,765
JBrowse link
G Trap1 TNF receptor-associated protein 1 multiple interactions
decreases response to substance
ISO diethyl maleate inhibits the reaction [Cisplatin results in decreased expression of TRAP1 protein]
TRAP1 protein results in decreased susceptibility to diethyl maleate
CTD PMID:17853063 NCBI chr16:3,857,835...3,895,704
Ensembl chr16:3,857,835...3,895,691
JBrowse link
G Trdmt1 tRNA aspartic acid methyltransferase 1 decreases expression EXP diethyl maleate results in decreased expression of TRDMT1 mRNA CTD PMID:25270620 NCBI chr 2:13,509,690...13,549,475
Ensembl chr 2:13,513,825...13,549,479
JBrowse link
G Trf transferrin decreases expression ISO diethyl maleate results in decreased expression of TF protein CTD PMID:21161181 NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643
JBrowse link
G Trib1 tribbles pseudokinase 1 increases expression ISO diethyl maleate results in increased expression of TRIB1 mRNA CTD PMID:33545341 NCBI chr15:59,520,503...59,528,948
Ensembl chr15:59,520,199...59,528,948
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO diethyl maleate results in increased expression of TRIB3 mRNA CTD PMID:33545341 NCBI chr 2:152,179,345...152,185,980
Ensembl chr 2:152,179,342...152,185,952
JBrowse link
G Trim6 tripartite motif-containing 6 decreases expression ISO diethyl maleate results in decreased expression of TRIM6 mRNA CTD PMID:21161181 NCBI chr 7:103,868,002...103,884,359
Ensembl chr 7:103,868,000...103,884,359
JBrowse link
G Trip13 thyroid hormone receptor interactor 13 increases expression ISO diethyl maleate results in increased expression of TRIP13 mRNA CTD PMID:21161181 NCBI chr13:74,060,577...74,085,855
Ensembl chr13:74,059,466...74,085,903
JBrowse link
G Trp53 transformation related protein 53 multiple interactions EXP
ISO
TRP53 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]
TP53 protein affects the reaction [diethyl maleate results in increased expression of CDKN1A protein]; TP53 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]
CTD PMID:22003191 PMID:27982581 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 decreases expression ISO diethyl maleate results in decreased expression of TSC22D1 mRNA CTD PMID:21161181 NCBI chr14:76,652,401...76,745,205
Ensembl chr14:76,652,401...76,745,205
JBrowse link
G Tspan8 tetraspanin 8 decreases expression ISO diethyl maleate results in decreased expression of TSPAN8 mRNA CTD PMID:21161181 NCBI chr10:115,652,722...115,685,798
Ensembl chr10:115,652,737...115,685,798
JBrowse link
G Tstd1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 decreases expression EXP diethyl maleate results in decreased expression of TSTD1 mRNA CTD PMID:25270620 NCBI chr 1:171,246,601...171,247,920
Ensembl chr 1:171,246,440...171,247,920
JBrowse link
G Txn1 thioredoxin 1 decreases activity ISO diethyl maleate results in decreased activity of TXN protein CTD PMID:15388247 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO diethyl maleate results in increased expression of TXNIP mRNA CTD PMID:21161181 NCBI chr 3:96,465,273...96,469,173
Ensembl chr 3:96,465,273...96,469,199
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO diethyl maleate results in increased expression of TXNRD1 mRNA CTD PMID:15521073 PMID:33545341 PMID:34480604 NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546
JBrowse link
G Ubd ubiquitin D decreases expression ISO diethyl maleate results in decreased expression of UBD mRNA CTD PMID:21161181 NCBI chr17:37,504,783...37,506,992
Ensembl chr17:37,504,783...37,506,986
JBrowse link
G Ugt2b35 UDP glucuronosyltransferase 2 family, polypeptide B35 increases expression EXP diethyl maleate results in increased expression of UGT2B35 mRNA CTD PMID:25270620 NCBI chr 5:87,148,719...87,161,133
Ensembl chr 5:87,148,719...87,161,134
JBrowse link
G Uhrf1 ubiquitin-like, containing PHD and RING finger domains, 1 increases expression ISO diethyl maleate results in increased expression of UHRF1 mRNA CTD PMID:21161181 NCBI chr17:56,610,405...56,630,486
Ensembl chr17:56,610,321...56,630,486
JBrowse link
G Usp18 ubiquitin specific peptidase 18 decreases expression ISO diethyl maleate results in decreased expression of USP18 mRNA CTD PMID:21161181 NCBI chr 6:121,222,865...121,247,876
Ensembl chr 6:121,222,865...121,247,876
JBrowse link
G Usp2 ubiquitin specific peptidase 2 decreases expression ISO diethyl maleate results in decreased expression of USP2 mRNA CTD PMID:21161181 NCBI chr 9:43,978,318...44,006,924
Ensembl chr 9:43,978,318...44,006,924
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO diethyl maleate results in increased expression of VEGFA mRNA CTD PMID:33545341 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link
G Wdr31 WD repeat domain 31 decreases expression EXP diethyl maleate results in decreased expression of WDR31 mRNA CTD PMID:25270620 NCBI chr 4:62,366,890...62,389,236
Ensembl chr 4:62,366,890...62,389,133
JBrowse link
G Wdr6 WD repeat domain 6 decreases expression ISO diethyl maleate results in decreased expression of WDR6 mRNA CTD PMID:21161181 NCBI chr 9:108,449,510...108,455,862
Ensembl chr 9:108,449,510...108,455,938
JBrowse link
G Ypel5 yippee like 5 increases expression EXP diethyl maleate results in increased expression of YPEL5 mRNA CTD PMID:25270620 NCBI chr17:73,143,623...73,157,439
Ensembl chr17:73,143,448...73,158,190
JBrowse link
G Zfand2a zinc finger, AN1-type domain 2A increases expression ISO diethyl maleate results in increased expression of ZFAND2A mRNA CTD PMID:33545341 PMID:34480604 NCBI chr 5:139,456,971...139,470,246
Ensembl chr 5:139,456,966...139,470,304
JBrowse link
G Zfp36 zinc finger protein 36 increases expression ISO diethyl maleate results in increased expression of ZFP36 protein CTD PMID:21969073 NCBI chr 7:28,076,208...28,078,680
Ensembl chr 7:28,076,209...28,079,678
JBrowse link
G Zfp367 zinc finger protein 367 increases expression ISO diethyl maleate results in increased expression of ZNF367 mRNA CTD PMID:21161181 NCBI chr13:64,280,836...64,301,013
Ensembl chr13:64,280,832...64,301,016
JBrowse link
G Zfp37 zinc finger protein 37 decreases expression ISO diethyl maleate results in decreased expression of ZFP37 mRNA CTD PMID:21161181 NCBI chr 4:62,107,777...62,126,685
Ensembl chr 4:62,107,777...62,149,284
JBrowse link
G Zfp493 zinc finger protein 493 decreases reduction EXP diethyl maleate results in decreased reduction of ZFP493 protein CTD PMID:19843705 NCBI chr13:67,927,812...67,937,201
Ensembl chr13:67,927,812...67,940,631
JBrowse link
G Znrd2 zinc ribbon domain containing 2 decreases expression EXP diethyl maleate results in decreased expression of ZNRD2 mRNA CTD PMID:25270620 NCBI chr19:5,780,334...5,781,760
Ensembl chr19:5,780,331...5,781,760
Ensembl chr19:5,780,331...5,781,760
JBrowse link
dimethyl fumarate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of ACSL4 protein] CTD PMID:35870111 NCBI chr  X:141,100,989...141,173,792
Ensembl chr  X:141,100,989...141,173,531
JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions ISO Dimethyl Fumarate inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:30703375 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGER protein]; Dimethyl Fumarate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGER protein] CTD PMID:36999408 NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910
JBrowse link
G Aifm2 apoptosis-inducing factor, mitochondrion-associated 2 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [Matrines results in decreased expression of AIFM2 mRNA]; Dimethyl Fumarate inhibits the reaction [Matrines results in decreased expression of AIFM2 protein] CTD PMID:38723914 NCBI chr10:61,551,042...61,575,474
Ensembl chr10:61,551,042...61,575,039
JBrowse link
G Atp6v0d2 ATPase, H+ transporting, lysosomal V0 subunit D2 multiple interactions EXP Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 mRNA] CTD PMID:30742845 NCBI chr 4:19,876,838...19,922,566
Ensembl chr 4:19,876,841...19,922,605
JBrowse link
G Bach1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 affects localization ISO Dimethyl Fumarate affects the localization of BACH1 protein CTD PMID:27277809 NCBI chr16:87,495,842...87,530,234
Ensembl chr16:87,495,833...87,530,234
JBrowse link
G Bdnf brain derived neurotrophic factor multiple interactions ISO Dimethyl Fumarate inhibits the reaction [Propylthiouracil results in decreased expression of BDNF mRNA]; Dimethyl Fumarate inhibits the reaction [Propylthiouracil results in decreased expression of BDNF protein] CTD PMID:35869475 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
JBrowse link
G Casp1 caspase 1 multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased cleavage of CASP1 protein]; Dimethyl Fumarate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased cleavage of CASP1 protein]
Dimethyl Fumarate inhibits the reaction [piperlongumine results in increased cleavage of CASP1 protein]
CTD PMID:36999408 PMID:38242274 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Cat catalase multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of CAT protein]; Dimethyl Fumarate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of CAT protein] CTD PMID:36999408 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
ISO
EXP
Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dimethyl Fumarate inhibits the reaction [IKBKB protein results in increased expression of CCL2 mRNA]; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to CCL2 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]
Dimethyl Fumarate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCL2 mRNA]
Dimethyl Fumarate results in decreased expression of CCL2 mRNA
CTD PMID:26683377 PMID:27277809 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Cd68 CD68 antigen multiple interactions EXP Dimethyl Fumarate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CD68 mRNA] CTD PMID:27277809 NCBI chr11:69,555,039...69,556,996
Ensembl chr11:69,555,039...69,556,979
JBrowse link
G Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) multiple interactions ISO Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of CD74 mRNA] CTD PMID:30021835 NCBI chr18:60,936,921...60,945,724
Ensembl chr18:60,936,920...60,945,724
JBrowse link
G Ciita class II transactivator multiple interactions ISO Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of CIITA mRNA] CTD PMID:30021835 NCBI chr16:10,297,877...10,348,928
Ensembl chr16:10,297,923...10,346,282
JBrowse link
G Csf1r colony stimulating factor 1 receptor multiple interactions EXP Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 mRNA]; Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA] CTD PMID:30742845 NCBI chr18:61,238,644...61,264,211
Ensembl chr18:61,233,670...61,265,221
JBrowse link
G Ctsk cathepsin K multiple interactions EXP Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA] CTD PMID:30742845 NCBI chr 3:95,406,521...95,416,698
Ensembl chr 3:95,406,567...95,416,673
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of CXCL10 mRNA] CTD PMID:30021835 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of CXCL9 mRNA] CTD PMID:30021835 NCBI chr 5:92,469,190...92,475,938
Ensembl chr 5:92,469,206...92,475,938
JBrowse link
G Fth1 ferritin heavy polypeptide 1 multiple interactions
increases expression
ISO Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of FTH1 protein]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTH1 mRNA]
Dimethyl Fumarate results in increased expression of FTH1 mRNA; Dimethyl Fumarate results in increased expression of FTH1 protein
CTD PMID:28289076 PMID:35870111 NCBI chr19:9,957,964...9,962,475
Ensembl chr19:9,957,962...9,962,462
JBrowse link
G Ftl1 ferritin light polypeptide 1 multiple interactions
increases expression
ISO NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTL mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTL protein]
Dimethyl Fumarate results in increased expression of FTL mRNA; Dimethyl Fumarate results in increased expression of FTL protein
CTD PMID:28289076 NCBI chr 7:45,107,368...45,109,310
Ensembl chr 7:45,107,368...45,109,308
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
EXP
ISO
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GCLC mRNA]
Dimethyl Fumarate results in increased expression of GCLC protein
CTD PMID:27277809 PMID:30248482 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression
multiple interactions
ISO
EXP
Dimethyl Fumarate results in increased expression of GCLM protein
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GCLM mRNA]
CTD PMID:27277809 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
JBrowse link
G Gpx4 glutathione peroxidase 4 increases metabolic processing
multiple interactions
ISO
EXP
Dimethyl Fumarate results in increased metabolism of GPX4 protein
Dimethyl Fumarate inhibits the reaction [Matrines results in decreased expression of GPX4 mRNA]; Dimethyl Fumarate inhibits the reaction [Matrines results in decreased expression of GPX4 protein]; Dimethyl Fumarate inhibits the reaction [sodium aescinate results in decreased expression of GPX4 protein]
Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of GPX4 protein]
CTD PMID:29917289 PMID:35870111 PMID:38364601 PMID:38723914 NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273
JBrowse link
G Gsdmd gasdermin D multiple interactions ISO Dimethyl Fumarate inhibits the reaction [piperlongumine results in increased expression of GSDMD protein] CTD PMID:38242274 NCBI chr15:75,733,990...75,739,257
Ensembl chr15:75,734,176...75,739,257
JBrowse link
G Gsr glutathione reductase increases expression
multiple interactions
ISO
EXP
Dimethyl Fumarate results in increased expression of GSR protein
Dimethyl Fumarate results in increased expression of GSR mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GSR mRNA]
CTD PMID:27277809 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
JBrowse link
G H2-Ea histocompatibility 2, class II antigen E alpha multiple interactions ISO Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of HLA-DRA mRNA] CTD PMID:30021835 NCBI chr17:34,560,926...34,563,619
Ensembl chr17:34,560,926...34,563,618
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP Dimethyl Fumarate inhibits the reaction [sodium aescinate results in increased expression of HAVCR1] CTD PMID:38364601 NCBI chr11:46,630,644...46,670,405
Ensembl chr11:46,625,907...46,670,405
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO
EXP
Dimethyl Fumarate results in increased expression of HMOX1 mRNA; Dimethyl Fumarate results in increased expression of HMOX1 protein
[Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; Dimethyl Fumarate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]
Acetylcysteine inhibits the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; HMOX1 protein inhibits the reaction [Dimethyl Fumarate inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]
[Dimethyl Fumarate results in decreased abundance of Glutathione] which results in increased expression of HMOX1 protein; [Dimethyl Fumarate results in increased expression of HMOX1 protein] which results in decreased susceptibility to PDGFB protein; Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of HMOX1 protein]; Glutathione inhibits the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]
CTD PMID:20961405 PMID:23942037 PMID:26683377 PMID:27277809 PMID:28790194 More... NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to ICAM1 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]
Dimethyl Fumarate results in decreased expression of ICAM1 mRNA
CTD PMID:26683377 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP
Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of CD74 mRNA]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of CIITA mRNA]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of CXCL10 mRNA]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of CXCL9 mRNA]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of HLA-DRA mRNA]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of IRF1 mRNA]; Dimethyl Fumarate inhibits the reaction [nickel sulfate results in increased secretion of IFNG protein]
Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased abundance of Dinoprostone]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; tin protoporphyrin IX inhibits the reaction [Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]
CTD PMID:15663561 PMID:23942037 PMID:30021835 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IGF1 protein]; Dimethyl Fumarate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IGF1 protein] CTD PMID:36999408 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904
JBrowse link
G Ikbkb inhibitor of kappaB kinase beta multiple interactions ISO Dimethyl Fumarate inhibits the reaction [IKBKB protein results in increased expression of CCL2 mRNA]; Dimethyl Fumarate inhibits the reaction [IKBKB protein results in increased expression of TNF mRNA] CTD PMID:26683377 NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605
JBrowse link
G Il18 interleukin 18 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [piperlongumine results in increased expression of IL18 protein] CTD PMID:38242274 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Dimethyl Fumarate inhibits the reaction [piperlongumine results in increased expression of IL1B protein] CTD PMID:38242274 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6ra interleukin 6 receptor, alpha decreases expression ISO Dimethyl Fumarate results in decreased expression of IL6R protein CTD PMID:28134847 NCBI chr 3:89,776,631...89,820,503
Ensembl chr 3:89,771,366...89,820,503
JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of IRF1 mRNA] CTD PMID:30021835 NCBI chr11:53,660,841...53,669,200
Ensembl chr11:53,660,841...53,669,200
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 multiple interactions
increases expression
EXP NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of LAMP2 protein alternative form] CTD PMID:29950142 NCBI chr  X:37,488,524...37,545,337
Ensembl chr  X:37,490,234...37,545,331
JBrowse link
G mt-Co3 cytochrome c oxidase III, mitochondrial increases expression
multiple interactions
EXP Dimethyl Fumarate results in increased expression of COX3 mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of COX3 mRNA]
CTD PMID:27277809 NCBI chr MT:8,607...9,390
Ensembl chr MT:8,607...9,390
JBrowse link
G mt-Cytb cytochrome b, mitochondrial multiple interactions
increases expression
EXP NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of CYTB mRNA] CTD PMID:27277809 NCBI chr MT:14,145...15,288
Ensembl chr MT:14,145...15,288
JBrowse link
G mt-Nd1 NADH dehydrogenase 1, mitochondrial increases expression
multiple interactions
EXP Dimethyl Fumarate results in increased expression of ND1 mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND1 mRNA]
CTD PMID:27277809 NCBI chr MT:2,751...3,707
Ensembl chr MT:2,751...3,707
JBrowse link
G mt-Nd2 NADH dehydrogenase 2, mitochondrial increases expression
multiple interactions
EXP Dimethyl Fumarate results in increased expression of ND2 mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND2 mRNA]
CTD PMID:27277809 NCBI chr MT:3,914...4,951
Ensembl chr MT:3,914...4,951
JBrowse link
G mt-Nd5 NADH dehydrogenase 5, mitochondrial multiple interactions
increases expression
EXP NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND5 mRNA] CTD PMID:27277809 NCBI chr MT:11,742...13,565
Ensembl chr MT:11,742...13,565
JBrowse link
G Mterf1a mitochondrial transcription termination factor 1a increases expression
multiple interactions
EXP Dimethyl Fumarate results in increased expression of MTERF1A mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of MTERF1A mRNA]
CTD PMID:27277809 NCBI chr 5:3,914,576...3,943,933
Ensembl chr 5:3,940,581...3,943,933
JBrowse link
G Mterf3 mitochondrial transcription termination factor 3 increases expression
multiple interactions
EXP Dimethyl Fumarate results in increased expression of MTERF3 mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of MTERF3 mRNA]
CTD PMID:27277809 NCBI chr13:67,053,520...67,081,148
Ensembl chr13:67,055,032...67,081,152
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
increases expression
affects localization
EXP
ISO
Dimethyl Fumarate inhibits the reaction [sodium aescinate results in decreased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of COX3 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of CYTB mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GCLC mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GCLM mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GSR mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of LAMP2 protein alternative form]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of MTERF1A mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of MTERF3 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND1 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND2 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND5 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of POLG2 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of POLRMT mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of SQSTM1 protein]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of SSBP1 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFAM mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFB1M mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFB2M mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TWNK mRNA]; NFE2L2 protein inhibits the reaction [Dimethyl Fumarate inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]; NFE2L2 protein promotes the reaction [Dimethyl Fumarate inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]]
[Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein]; Dimethyl Fumarate affects the reaction [Matrines affects the localization of NFE2L2 protein]; Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of NFE2L2 protein]; Dimethyl Fumarate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein]
Dimethyl Fumarate results in increased expression of NFE2L2 protein
Dimethyl Fumarate affects the localization of NFE2L2 protein
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTH1 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTL mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTL protein]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]
CTD PMID:23942037 PMID:27277809 PMID:28289076 PMID:28790194 PMID:29950142 More... NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NFKB1 protein]; Dimethyl Fumarate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NFKB1 protein] CTD PMID:36999408 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NLRP3 protein]; Dimethyl Fumarate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NLRP3 protein]
Dimethyl Fumarate inhibits the reaction [piperlongumine results in increased expression of NLRP3 protein]
CTD PMID:36999408 PMID:38242274 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases activity
increases expression
multiple interactions
ISO
EXP
Dimethyl Fumarate results in increased activity of NQO1 protein
Dimethyl Fumarate results in increased expression of NQO1 mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of NQO1 mRNA]
Dimethyl Fumarate results in increased expression of NQO1 mRNA; Dimethyl Fumarate results in increased expression of NQO1 protein
[Dimethyl Fumarate results in increased activity of NQO1 protein] which results in increased susceptibility to Mitomycin; [Dimethyl Fumarate results in increased activity of NQO1 protein] which results in increased susceptibility to Streptonigrin
CTD PMID:15655414 PMID:16045903 PMID:27277809 PMID:28790194 PMID:30248482 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Pdgfb platelet derived growth factor, B polypeptide multiple interactions ISO [Dimethyl Fumarate results in increased expression of HMOX1 protein] which results in decreased susceptibility to PDGFB protein CTD PMID:20961405 NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178
JBrowse link
G Polg2 polymerase (DNA directed), gamma 2, accessory subunit increases expression
multiple interactions
EXP Dimethyl Fumarate results in increased expression of POLG2 mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of POLG2 mRNA]
CTD PMID:27277809 NCBI chr11:106,659,030...106,670,363
Ensembl chr11:106,659,079...106,670,363
JBrowse link
G Polrmt polymerase (RNA) mitochondrial (DNA directed) increases expression
multiple interactions
EXP Dimethyl Fumarate results in increased expression of POLRMT mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of POLRMT mRNA]
CTD PMID:27277809 NCBI chr10:79,571,951...79,582,436
Ensembl chr10:79,571,957...79,582,415
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO Dimethyl Fumarate inhibits the reaction [piperlongumine results in increased expression of PYCARD protein] CTD PMID:38242274 NCBI chr 7:127,590,545...127,593,039
Ensembl chr 7:127,588,880...127,593,039
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Dimethyl Fumarate binds to and affects the localization of and results in decreased activity of RELA protein; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to CCL2 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to ICAM1 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased activity of RELA protein] CTD PMID:26683377 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of RIPK3 protein] CTD PMID:36000575 NCBI chr14:56,022,452...56,026,314
Ensembl chr14:56,022,452...56,026,322
JBrowse link
G Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of SLC40A1 protein] CTD PMID:35870111 NCBI chr 1:45,947,230...45,965,690
Ensembl chr 1:45,947,228...45,965,683
JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of SLC7A11 protein] CTD PMID:35870111 NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063
JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions ISO [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of SOD1 protein]; Dimethyl Fumarate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of SOD1 protein] CTD PMID:36999408 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression
EXP NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of SQSTM1 protein] CTD PMID:29950142 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654
JBrowse link
G Ssbp1 single-stranded DNA binding protein 1 multiple interactions
increases expression
EXP NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of SSBP1 mRNA] CTD PMID:27277809 NCBI chr 6:40,448,302...40,458,757
Ensembl chr 6:40,448,286...40,461,634
JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions
increases expression
EXP NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFAM mRNA] CTD PMID:27277809 NCBI chr10:71,061,298...71,074,157
Ensembl chr10:71,061,294...71,074,110
JBrowse link
G Tfb1m transcription factor B1, mitochondrial increases expression
multiple interactions
EXP Dimethyl Fumarate results in increased expression of TFB1M mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFB1M mRNA]
CTD PMID:27277809 NCBI chr17:3,569,119...3,608,064
Ensembl chr17:3,569,531...3,608,056
JBrowse link
G Tfb2m transcription factor B2, mitochondrial increases expression
multiple interactions
EXP Dimethyl Fumarate results in increased expression of TFB2M mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFB2M mRNA]
CTD PMID:27277809 NCBI chr 1:179,355,617...179,373,870
Ensembl chr 1:179,355,620...179,373,832
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein] CTD PMID:30703375 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of TNF mRNA]]; Dimethyl Fumarate inhibits the reaction [IKBKB protein results in increased expression of TNF mRNA]; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to CCL2 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to ICAM1 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased activity of RELA protein]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of TNF mRNA]
Dimethyl Fumarate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF mRNA]
Dimethyl Fumarate results in decreased expression of TNF mRNA
CTD PMID:26683377 PMID:27277809 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 multiple interactions EXP Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 mRNA]; Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA] CTD PMID:30742845 NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483
JBrowse link
G Twnk twinkle mtDNA helicase multiple interactions
increases expression
EXP NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TWNK mRNA] CTD PMID:27277809 NCBI chr19:44,994,102...45,001,203
Ensembl chr19:44,994,102...45,001,201
JBrowse link
dimethyl maleate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO dimethyl maleate results in increased cleavage of PARP1 protein CTD PMID:21105742 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Sptan1 spectrin alpha, non-erythrocytic 1 increases cleavage ISO dimethyl maleate results in increased cleavage of SPTAN1 protein CTD PMID:21105742 NCBI chr 2:29,855,572...29,921,463
Ensembl chr 2:29,855,572...29,921,463
JBrowse link
fumaric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions EXP [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of fumaric acid; IDO1 protein affects the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of fumaric acid] CTD PMID:39172838 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions EXP fumaric acid inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]; fumaric acid inhibits the reaction [TNF protein results in increased expression of CCL11 protein] CTD PMID:23707484 NCBI chr11:81,948,658...81,953,781
Ensembl chr11:81,948,649...81,953,781
JBrowse link
G Ccr3 C-C motif chemokine receptor 3 multiple interactions EXP fumaric acid inhibits the reaction [TNF protein results in increased expression of CCR3 protein] CTD PMID:23707484 NCBI chr 9:123,817,799...123,831,729
Ensembl chr 9:123,822,009...123,831,726
JBrowse link
G Hlcs holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) decreases activity ISO fumaric acid results in decreased activity of HLCS protein CTD PMID:26303405 NCBI chr16:93,930,054...94,116,098
Ensembl chr16:93,929,741...94,114,430
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP fumaric acid inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:23707484 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 multiple interactions EXP IDO1 protein affects the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of fumaric acid] CTD PMID:39172838 NCBI chr 8:25,074,148...25,086,987
Ensembl chr 8:25,074,152...25,087,025
JBrowse link
G Lepr leptin receptor affects abundance EXP LEPR affects the abundance of fumaric acid CTD PMID:20567778 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions
decreases abundance
ISO PF-06840003 inhibits the reaction [MAPT protein mutant form results in decreased abundance of fumaric acid] CTD PMID:39172838 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP fumaric acid inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] CTD PMID:23707484 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
JBrowse link
G Psen1 presenilin 1 multiple interactions EXP [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of fumaric acid; IDO1 protein affects the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of fumaric acid] CTD PMID:39172838 NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP fumaric acid inhibits the reaction [TNF protein affects the localization of RELA protein] CTD PMID:23707484 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP fumaric acid inhibits the reaction [TNF protein affects the localization of RELA protein]; fumaric acid inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]; fumaric acid inhibits the reaction [TNF protein results in increased expression of CCL11 protein]; fumaric acid inhibits the reaction [TNF protein results in increased expression of CCR3 protein]; fumaric acid inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; fumaric acid inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; fumaric acid inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] CTD PMID:23707484 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP fumaric acid inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:23707484 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337
JBrowse link
maleic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 6430550D23Rik RIKEN cDNA 6430550D23 gene increases expression ISO maleic acid results in increased expression of C20ORF173 mRNA CTD PMID:28392987 NCBI chr 2:155,831,465...155,850,315
Ensembl chr 2:155,815,199...155,849,897
JBrowse link
G Abca7 ATP-binding cassette, sub-family A member 7 increases expression ISO maleic acid results in increased expression of ABCA7 mRNA CTD PMID:28392987 NCBI chr10:79,832,328...79,851,406
Ensembl chr10:79,832,328...79,851,406
JBrowse link
G Agap1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 increases expression ISO maleic acid results in increased expression of AGAP1 mRNA CTD PMID:28392987 NCBI chr 1:89,382,533...89,823,004
Ensembl chr 1:89,382,528...89,825,339
JBrowse link
G Akt2 thymoma viral proto-oncogene 2 decreases expression ISO maleic acid results in decreased expression of AKT2 mRNA CTD PMID:28392987 NCBI chr 7:27,290,977...27,340,251
Ensembl chr 7:27,290,977...27,340,251
JBrowse link
G B4galnt4 beta-1,4-N-acetyl-galactosaminyl transferase 4 decreases expression ISO maleic acid results in decreased expression of B4GALNT4 mRNA CTD PMID:28392987 NCBI chr 7:140,640,891...140,652,313
Ensembl chr 7:140,641,017...140,652,313
JBrowse link
G Ccbe1 collagen and calcium binding EGF domains 1 increases expression ISO maleic acid results in increased expression of CCBE1 mRNA CTD PMID:28392987 NCBI chr18:66,189,926...66,424,909
Ensembl chr18:66,178,373...66,435,812
JBrowse link
G Cldn2 claudin 2 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [maleic acid results in decreased expression of CLDN2] CTD PMID:25119790 NCBI chr  X:138,701,552...138,712,135
Ensembl chr  X:138,701,577...138,712,135
JBrowse link
G Cldn25 claudin 25 increases expression ISO maleic acid results in increased expression of CLDN25 mRNA CTD PMID:28392987 NCBI chr 9:48,958,857...48,959,642
Ensembl chr 9:48,958,902...48,959,642
JBrowse link
G Cracr2b calcium release activated channel regulator 2B increases expression ISO maleic acid results in increased expression of CRACR2B mRNA CTD PMID:28392987 NCBI chr 7:141,041,007...141,046,526
Ensembl chr 7:141,041,007...141,046,526
JBrowse link
G Exoc3l2 exocyst complex component 3-like 2 increases expression ISO maleic acid results in increased expression of EXOC3L2 mRNA CTD PMID:28392987 NCBI chr 7:19,197,212...19,230,687
Ensembl chr 7:19,197,256...19,230,687
JBrowse link
G Fbxo40 F-box protein 40 increases expression ISO maleic acid results in increased expression of FBXO40 mRNA CTD PMID:28392987 NCBI chr16:36,783,823...36,811,321
Ensembl chr16:36,783,822...36,810,829
JBrowse link
G Fcgr1 Fc receptor, IgG, high affinity I increases expression ISO maleic acid results in increased expression of FCGR1A mRNA CTD PMID:28392987 NCBI chr 3:96,190,225...96,201,285
Ensembl chr 3:96,190,225...96,201,285
JBrowse link
G Fmo1 flavin containing monooxygenase 1 increases expression ISO maleic acid results in increased expression of FMO1 mRNA CTD PMID:28392987 NCBI chr 1:162,657,130...162,694,170
Ensembl chr 1:162,657,130...162,694,179
JBrowse link
G Gab3 growth factor receptor bound protein 2-associated protein 3 increases expression ISO maleic acid results in increased expression of GAB3 mRNA CTD PMID:28392987 NCBI chr  X:74,032,151...74,128,511
Ensembl chr  X:74,010,449...74,129,064
JBrowse link
G Ggt5 gamma-glutamyltransferase 5 increases expression ISO maleic acid results in increased expression of GGT5 mRNA CTD PMID:28392987 NCBI chr10:75,425,161...75,453,034
Ensembl chr10:75,425,174...75,453,034
JBrowse link
G Gnrhr gonadotropin releasing hormone receptor increases expression ISO maleic acid results in increased expression of GNRHR mRNA CTD PMID:28392987 NCBI chr 5:86,328,613...86,345,760
Ensembl chr 5:86,328,613...86,345,760
JBrowse link
G Gria1 glutamate receptor, ionotropic, AMPA1 (alpha 1) increases expression ISO maleic acid results in increased expression of GRIA1 mRNA CTD PMID:28392987 NCBI chr11:56,902,342...57,221,070
Ensembl chr11:56,902,213...57,221,070
JBrowse link
G H2bc8 H2B clustered histone 8 decreases expression ISO maleic acid results in decreased expression of H2BC8 mRNA CTD PMID:28392987 NCBI chr13:23,755,574...23,756,037
Ensembl chr13:23,755,570...23,756,187
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression
multiple interactions
ISO maleic acid results in increased expression of HAVCR1 protein
Curcumin inhibits the reaction [maleic acid results in increased expression of HAVCR1 protein]
CTD PMID:25119790 NCBI chr11:46,630,644...46,670,405
Ensembl chr11:46,625,907...46,670,405
JBrowse link
G Hmox1 heme oxygenase 1 affects expression ISO maleic acid affects the expression of HMOX1 mRNA CTD PMID:22954530 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO maleic acid results in increased expression of IGF1 mRNA CTD PMID:28392987 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904
JBrowse link
G Kcnc1 potassium voltage gated channel, Shaw-related subfamily, member 1 decreases expression ISO maleic acid results in decreased expression of KCNC1 mRNA CTD PMID:28392987 NCBI chr 7:46,045,643...46,088,130
Ensembl chr 7:46,045,921...46,088,128
JBrowse link
G Lcn2 lipocalin 2 multiple interactions
increases secretion
ISO Curcumin inhibits the reaction [maleic acid results in increased secretion of LCN2 protein] CTD PMID:25119790 NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264
JBrowse link
G Nfat5 nuclear factor of activated T cells 5 increases expression ISO maleic acid results in increased expression of NFAT5 mRNA CTD PMID:28392987 NCBI chr 8:108,020,072...108,106,149
Ensembl chr 8:108,020,102...108,106,149
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
affects expression
ISO Curcumin inhibits the reaction [maleic acid affects the expression of NFE2L2 protein] CTD PMID:25119790 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Or11g2 olfactory receptor family 11 subfamily G member 2 increases expression ISO maleic acid results in increased expression of OR11G2 mRNA CTD PMID:28392987 NCBI chr14:50,855,681...50,856,652
Ensembl chr14:50,852,336...50,857,296
JBrowse link
G Or6c65 olfactory receptor family 6 subfamily C member 65 increases expression ISO maleic acid results in increased expression of OR6C65 mRNA CTD PMID:28392987 NCBI chr10:129,603,367...129,604,305
Ensembl chr10:129,601,351...129,607,582
JBrowse link
G Pcdhac1 protocadherin alpha subfamily C, 1 increases expression ISO maleic acid results in increased expression of PCDHAC1 mRNA CTD PMID:28392987 NCBI chr18:37,223,189...37,320,710
Ensembl chr18:37,223,066...37,320,710
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase 1 decreases expression ISO maleic acid results in decreased expression of PDPK1 mRNA CTD PMID:28392987 NCBI chr17:24,292,654...24,370,957
Ensembl chr17:24,292,654...24,369,898
JBrowse link
G Pkd1l1 polycystic kidney disease 1 like 1 increases expression ISO maleic acid results in increased expression of PKD1L1 mRNA CTD PMID:28392987 NCBI chr11:8,782,025...8,924,365
Ensembl chr11:8,776,708...8,938,709
JBrowse link
G Rsph6a radial spoke head 6 homolog A (Chlamydomonas) increases expression ISO maleic acid results in increased expression of RSPH6A mRNA CTD PMID:28392987 NCBI chr 7:18,788,603...18,808,384
Ensembl chr 7:18,788,615...18,808,372
JBrowse link
G S100a3 S100 calcium binding protein A3 increases expression ISO maleic acid results in increased expression of S100A3 mRNA CTD PMID:28392987 NCBI chr 3:90,467,571...90,510,922
Ensembl chr 3:90,491,966...90,510,009
JBrowse link
G Skap1 src family associated phosphoprotein 1 increases expression ISO maleic acid results in increased expression of SKAP1 mRNA CTD PMID:28392987 NCBI chr11:96,355,396...96,650,448
Ensembl chr11:96,355,419...96,649,956
JBrowse link
G Slc25a48 solute carrier family 25, member 48 increases expression ISO maleic acid results in increased expression of SLC25A48 mRNA CTD PMID:28392987 NCBI chr13:56,585,774...56,620,180
Ensembl chr13:56,586,168...56,622,052
JBrowse link
G Sox17 SRY (sex determining region Y)-box 17 increases expression ISO maleic acid results in increased expression of SOX17 mRNA CTD PMID:28392987 NCBI chr 1:4,561,154...4,567,624
Ensembl chr 1:4,561,154...4,567,577
JBrowse link
G Spata1 spermatogenesis associated 1 increases expression ISO maleic acid results in increased expression of SPATA1 mRNA CTD PMID:28392987 NCBI chr 3:146,162,955...146,205,548
Ensembl chr 3:146,162,951...146,205,508
JBrowse link
G Spem1 spermatid maturation 1 increases expression ISO maleic acid results in increased expression of SPEM1 mRNA CTD PMID:28392987 NCBI chr11:69,711,697...69,712,991
Ensembl chr11:69,711,702...69,713,006
JBrowse link
G Tcaf2 TRPM8 channel-associated factor 2 increases expression ISO maleic acid results in increased expression of TCAF2 mRNA CTD PMID:28392987 NCBI chr 6:42,599,950...42,622,134
Ensembl chr 6:42,599,950...42,622,188
JBrowse link
G Tnf tumor necrosis factor increases expression ISO maleic acid results in increased expression of TNF mRNA CTD PMID:28392987 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Zfp800 zinc finger protein 800 decreases expression ISO maleic acid results in decreased expression of ZNF800 mRNA CTD PMID:28392987 NCBI chr 6:28,210,543...28,398,010
Ensembl chr 6:28,239,926...28,398,004
JBrowse link
G Zgrf1 zinc finger, GRF-type containing 1 decreases expression ISO maleic acid results in decreased expression of ZGRF1 mRNA CTD PMID:28392987 NCBI chr 3:127,347,080...127,411,672
Ensembl chr 3:127,347,138...127,411,672
JBrowse link
maleimide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trp53 transformation related protein 53 multiple interactions ISO maleimide analog binds to and results in increased activity of TP53 protein mutant form CTD PMID:15998635 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
maleimides term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases activity ISO Maleimides analog results in decreased activity of PTGS2 protein CTD PMID:8648609 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
N-ethylmaleimide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A decreases activity ISO Ethylmaleimide results in decreased activity of ABCB1 protein CTD PMID:2900677 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Abcc1 ATP-binding cassette, sub-family C member 1 affects activity
multiple interactions
ISO Ethylmaleimide affects the activity of ABCC1 protein
Ethylmaleimide inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]
CTD PMID:9096673 PMID:9334814 PMID:16101123 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601
JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 decreases activity ISO Ethylmaleimide results in decreased activity of ACSL4 protein CTD PMID:11319222 NCBI chr  X:141,100,989...141,173,792
Ensembl chr  X:141,100,989...141,173,531
JBrowse link
G Alb albumin decreases transport ISO Ethylmaleimide results in decreased transport of ALB protein CTD PMID:15897811 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
JBrowse link
G Apex1 apurinic/apyrimidinic endonuclease 1 multiple interactions ISO Ethylmaleimide inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]] CTD PMID:23370007 NCBI chr14:51,162,406...51,164,645
Ensembl chr14:51,162,425...51,164,596
JBrowse link
G Atp7a ATPase, copper transporting, alpha polypeptide multiple interactions
increases glutathionylation
ISO Dithiothreitol inhibits the reaction [Ethylmaleimide results in increased glutathionylation of ATP7A protein] CTD PMID:20566629 NCBI chr  X:105,070,830...105,171,766
Ensembl chr  X:105,070,882...105,168,532
JBrowse link
G Atp8b1 ATPase, class I, type 8B, member 1 multiple interactions ISO Ethylmaleimide inhibits the reaction [ATP8B1 protein results in increased transport of Phosphatidylserines] CTD PMID:11584374 NCBI chr18:64,662,050...64,794,342
Ensembl chr18:64,662,038...64,794,338
JBrowse link
G Cbr2 carbonyl reductase 2 increases acylation EXP Ethylmaleimide results in increased acylation of CBR2 protein CTD PMID:18597497 NCBI chr11:120,620,311...120,622,851
Ensembl chr11:120,620,315...120,622,940
JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator multiple interactions ISO Ethylmaleimide inhibits the reaction [Glutathione results in decreased activity of CFTR protein] CTD PMID:15657297 NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767
JBrowse link
G Chat choline O-acetyltransferase decreases activity EXP Ethylmaleimide results in decreased activity of CHAT protein CTD PMID:3437937 NCBI chr14:32,130,160...32,187,866
Ensembl chr14:32,130,160...32,187,946
JBrowse link
G Chuk conserved helix-loop-helix ubiquitous kinase multiple interactions EXP Ethylmaleimide inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein] CTD PMID:10820281 NCBI chr19:44,061,773...44,095,940
Ensembl chr19:44,061,774...44,095,919
JBrowse link
G Dusp23 dual specificity phosphatase 23 multiple interactions ISO Ethylmaleimide inhibits the reaction [DUSP23 protein results in decreased phosphorylation of nitrophenylphosphate] CTD PMID:15147733 NCBI chr 1:172,458,336...172,460,504
Ensembl chr 1:172,458,331...172,460,529
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO Ethylmaleimide results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697
JBrowse link
G Gad1 glutamate decarboxylase 1 decreases activity ISO Ethylmaleimide results in decreased activity of GAD1 protein CTD PMID:15836621 NCBI chr 2:70,392,109...70,432,358
Ensembl chr 2:70,383,416...70,432,358
JBrowse link
G Gad2 glutamic acid decarboxylase 2 decreases activity ISO Ethylmaleimide results in decreased activity of GAD2 protein CTD PMID:15836621 NCBI chr 2:22,512,262...22,583,889
Ensembl chr 2:22,512,217...22,583,886
JBrowse link
G Hoxb13 homeobox B13 increases response to substance ISO HOXB13 protein results in increased susceptibility to Ethylmaleimide CTD PMID:24213000 NCBI chr11:96,085,142...96,087,436
Ensembl chr11:96,085,142...96,088,273
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions ISO Ethylmaleimide promotes the reaction [Thiram results in decreased activity of HSD11B2 protein] CTD PMID:22796344 NCBI chr 8:106,245,378...106,250,620
Ensembl chr 8:106,245,387...106,250,620
JBrowse link
G Idh1 isocitrate dehydrogenase 1 (NADP+), soluble multiple interactions
decreases activity
ISO isocitric acid inhibits the reaction [Ethylmaleimide results in decreased activity of IDH1 protein]; NADP promotes the reaction [Ethylmaleimide results in decreased activity of IDH1 protein] CTD PMID:8486157 NCBI chr 1:65,197,775...65,225,638
Ensembl chr 1:65,197,775...65,225,659
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
JBrowse link
G Ltbr lymphotoxin B receptor multiple interactions ISO Ethylmaleimide promotes the reaction [OSM protein binds to LTBR protein] CTD PMID:37193757 NCBI chr 6:125,283,534...125,291,026
Ensembl chr 6:125,283,534...125,290,848
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO Ethylmaleimide inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]] CTD PMID:23370007 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mt3 metallothionein 3 increases alkylation ISO Ethylmaleimide results in increased alkylation of MT3 protein CTD PMID:12383939 NCBI chr 8:94,879,235...94,880,776
Ensembl chr 8:94,879,235...94,880,774
JBrowse link
G Osm oncostatin M multiple interactions ISO Ethylmaleimide promotes the reaction [OSM protein binds to LTBR protein] CTD PMID:37193757 NCBI chr11:4,186,831...4,191,027
Ensembl chr11:4,186,420...4,191,026
JBrowse link
G Pah phenylalanine hydroxylase multiple interactions EXP Ethylmaleimide results in increased activity of [PAH protein binds to PAH protein binds to PAH protein binds to PAH protein] CTD PMID:19367645 NCBI chr10:87,357,657...87,419,999
Ensembl chr10:87,357,657...87,419,998
JBrowse link
G Senp1 SUMO1/sentrin specific peptidase 1 multiple interactions ISO Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP1 protein] CTD PMID:26060329 NCBI chr15:97,936,625...97,991,625
Ensembl chr15:97,936,625...97,991,625
JBrowse link
G Senp6 SUMO/sentrin specific peptidase 6 multiple interactions ISO Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP6 protein] CTD PMID:26060329 NCBI chr 9:79,973,862...80,052,064
Ensembl chr 9:79,974,185...80,052,235
JBrowse link
G Slc12a5 solute carrier family 12, member 5 increases activity
multiple interactions
ISO Ethylmaleimide results in increased activity of SLC12A5 protein
Ethylmaleimide inhibits the reaction [SLC12A5 protein results in increased import of Thallium]
CTD PMID:20086212 NCBI chr 2:164,802,766...164,841,651
Ensembl chr 2:164,802,722...164,841,651
JBrowse link
G Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 multiple interactions ISO Ethylmaleimide inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid] CTD PMID:15804185 NCBI chr 3:104,545,980...104,565,778
Ensembl chr 3:104,545,984...104,565,778
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions ISO Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Sp1 trans-acting transcription factor 1 multiple interactions EXP
ISO
Ethylmaleimide inhibits the reaction [CD 437 results in increased cleavage of SP1 protein] CTD PMID:9343396 NCBI chr15:102,314,751...102,344,839
Ensembl chr15:102,314,578...102,344,839
JBrowse link
G Sumo2 small ubiquitin-like modifier 2 multiple interactions ISO Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP1 protein]; Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP6 protein] CTD PMID:26060329 NCBI chr11:115,413,935...115,427,056
Ensembl chr11:115,413,928...115,427,102
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO Ethylmaleimide inhibits the reaction [Clozapine results in decreased expression of TH protein] CTD PMID:15983997 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Trf transferrin decreases uptake EXP Ethylmaleimide results in decreased uptake of TF protein CTD PMID:10865941 NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643
JBrowse link
G Vdac1 voltage-dependent anion channel 1 affects binding ISO Ethylmaleimide binds to VDAC1 protein CTD PMID:20192921 NCBI chr11:52,251,905...52,280,224
Ensembl chr11:52,251,687...52,280,224
JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 multiple interactions
decreases activity
ISO Dithiothreitol promotes the reaction [Ethylmaleimide results in decreased activity of VKORC1 protein] CTD PMID:2319331 NCBI chr 7:127,492,235...127,494,833
Ensembl chr 7:127,485,399...127,494,626
Ensembl chr 7:127,485,399...127,494,626
JBrowse link
N-Ethylmaleimide-S-glutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc6 ATP-binding cassette, sub-family C member 6 multiple interactions
affects transport
ISO Benzbromarone inhibits the reaction [ABCC6 protein affects the transport of N-ethylmaleimide-S-glutathione]; Indomethacin inhibits the reaction [ABCC6 protein affects the transport of N-ethylmaleimide-S-glutathione]; Probenecid inhibits the reaction [ABCC6 protein affects the transport of N-ethylmaleimide-S-glutathione] CTD PMID:11880368 NCBI chr 7:45,625,804...45,679,915
Ensembl chr 7:45,616,979...45,679,726
JBrowse link
Ro 31-8220 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP-binding cassette, sub-family A member 1 multiple interactions
decreases expression
ISO Ro 31-8220 inhibits the reaction [5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-monophosphorothioate results in increased expression of ABCA1 mRNA]
Ro 31-8220 results in decreased expression of ABCA1 mRNA
CTD PMID:15037193 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895
JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions ISO Ro 31-8220 inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:16757516 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990
JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 multiple interactions ISO Ro 31-8220 inhibits the reaction [panaxytriol results in increased activity of AKR1C3 protein] CTD PMID:18826220 NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653
JBrowse link
G Akr1c21 aldo-keto reductase family 1, member C21 multiple interactions ISO Ro 31-8220 inhibits the reaction [panaxytriol results in increased activity of AKR1C2 protein] CTD PMID:18826220 NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540
JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO Ro 31-8220 promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of BAX protein] CTD PMID:36925031 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO Ro 31-8220 promotes the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of BCL2 protein] CTD PMID:36925031 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions ISO Ro 31-8220 inhibits the reaction [Hexachlorocyclohexane results in increased expression of BCL2L1 protein] CTD PMID:22001173 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO Ro 31-8220 results in increased activity of CASP3 protein
Ro 31-8220 inhibits the reaction [Hexachlorocyclohexane results in increased activity of CASP3 protein]; Ro 31-8220 inhibits the reaction [Paraoxon results in increased activity of CASP3 protein]
CTD PMID:17561261 PMID:18054255 PMID:22001173 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp8 caspase 8 increases activity ISO Ro 31-8220 results in increased activity of CASP8 protein CTD PMID:18054255 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Ro 31-8220 inhibits the reaction [Hexachlorocyclohexane results in increased activity of CASP9 protein] CTD PMID:22001173 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cd38 CD38 antigen multiple interactions ISO Ro 31-8220 inhibits the reaction [Tretinoin results in increased expression of CD38 mRNA] CTD PMID:21393419 NCBI chr 5:44,026,153...44,069,714
Ensembl chr 5:44,025,895...44,069,717
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Ro 31-8220 inhibits the reaction [Formaldehyde results in increased phosphorylation of CREB1 protein]; Ro 31-8220 inhibits the reaction [Tretinoin results in increased phosphorylation of CREB1 protein]
Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]
CTD PMID:15522277 PMID:16280361 PMID:22138297 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO Ro 31-8220 inhibits the reaction [Neurotensin results in increased expression of CXCL8 mRNA] CTD PMID:17000667 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Dpp3 dipeptidylpeptidase 3 multiple interactions ISO Ro 31-8220 inhibits the reaction [DPP3 protein results in increased expression of NQO1 protein] CTD PMID:17360324 NCBI chr19:4,957,257...4,978,315
Ensembl chr19:4,957,257...4,978,315
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Ro 31-8220 inhibits the reaction [EDN1 protein results in increased phosphorylation of JUN protein] CTD PMID:12169099 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466
JBrowse link
G Egf epidermal growth factor multiple interactions ISO Ro 31-8220 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ro 31-8220 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of EGF protein] CTD PMID:12947092 PMID:16877402 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965
JBrowse link
G Fcer1a Fc receptor, IgE, high affinity I, alpha polypeptide multiple interactions EXP Ro 31-8220 inhibits the reaction [FCER1A protein results in increased expression of IL6 mRNA]; Ro 31-8220 inhibits the reaction [FCER1A protein results in increased expression of TNF mRNA] CTD PMID:16818790 NCBI chr 1:173,048,836...173,054,799
Ensembl chr 1:173,048,851...173,054,781
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions
decreases expression
EXP Ro 31-8220 inhibits the reaction [beryllium sulfate results in increased expression of FOS mRNA]; Ro 31-8220 inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA]
Ro 31-8220 results in decreased expression of FOS mRNA
CTD PMID:11353138 PMID:11568973 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions ISO Ro 31-8220 inhibits the reaction [gingerol results in increased expression of GDF15 protein] CTD PMID:18058799 NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO Ro 31-8220 promotes the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of and results in decreased phosphorylation of GJA1 protein] CTD PMID:36925031 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609
JBrowse link
G Grp gastrin releasing peptide multiple interactions ISO Ro 31-8220 promotes the reaction [GRP protein modified form results in increased chemical synthesis of Inositol Phosphates] CTD PMID:18313772 NCBI chr18:66,005,826...66,019,670
Ensembl chr18:66,005,891...66,019,667
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases activity ISO Ro 31-8220 results in decreased activity of GSK3B protein CTD PMID:10998351 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Ro 31-8220 inhibits the reaction [Acrolein results in increased expression of HMOX1 mRNA]; Ro 31-8220 inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; Ro 31-8220 inhibits the reaction [Curcumin results in increased expression of HMOX1 protein] CTD PMID:18048804 PMID:18357586 PMID:26275128 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Hrh1 histamine receptor H1 multiple interactions ISO Ro 31-8220 inhibits the reaction [Histamine results in increased expression of HRH1 mRNA] CTD PMID:18360087 NCBI chr 6:114,374,897...114,459,432
Ensembl chr 6:114,374,897...114,460,257
JBrowse link
G Il11 interleukin 11 multiple interactions ISO Ro 31-8220 inhibits the reaction [Formaldehyde results in increased expression of IL11 mRNA]; Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL11 mRNA] CTD PMID:22138297 NCBI chr 7:4,775,372...4,785,877
Ensembl chr 7:4,775,372...4,785,858
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Ro 31-8220 inhibits the reaction [bufalin results in increased expression of IL1B mRNA]; Ro 31-8220 inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Ro 31-8220 inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein] CTD PMID:10712238 PMID:11854442 PMID:18054255 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Ro 31-8220 inhibits the reaction [FCER1A protein results in increased expression of IL6 mRNA] CTD PMID:16818790 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Ins1 insulin I multiple interactions EXP
ISO
Ro 31-8220 inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]
Ro 31-8220 inhibits the reaction [apigenin-6-C-(2''-O-rhamnopyranosyl)-fucopyranoside promotes the reaction [Glucose results in increased secretion of INS1 protein]]
CTD PMID:14511371 PMID:19070612 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914
JBrowse link
G Jun jun proto-oncogene multiple interactions
decreases expression
EXP
ISO
Ro 31-8220 inhibits the reaction [beryllium sulfate results in increased expression of JUN mRNA]; Ro 31-8220 inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]
Ro 31-8220 results in decreased expression of JUN mRNA
Ro 31-8220 inhibits the reaction [EDN1 protein results in increased phosphorylation of JUN protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]
CTD PMID:11353138 PMID:11568973 PMID:12169099 PMID:19002563 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO
EXP
Ro 31-8220 inhibits the reaction [bufalin results in increased phosphorylation of MAPK1 protein]
Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
Ro 31-8220 inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ro 31-8220 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD PMID:10712238 PMID:12083801 PMID:16877402 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO
EXP
Ro 31-8220 inhibits the reaction [bufalin results in increased phosphorylation of MAPK3 protein]
Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
Ro 31-8220 inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Ro 31-8220 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Ro 31-8220 inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:10712238 PMID:12083801 PMID:16877402 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases activity
ISO Ro 31-8220 inhibits the reaction [Arsenic results in decreased phosphorylation of and results in decreased activity of MAPK8 protein]
Ro 31-8220 results in increased activity of MAPK8 protein
CTD PMID:11027531 PMID:11756236 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO Ro 31-8220 inhibits the reaction [Arsenic results in decreased phosphorylation of and results in decreased activity of MAPK9 protein] CTD PMID:11756236 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Ro 31-8220 inhibits the reaction [Arachidonic Acid results in increased phosphorylation of MAPT protein] CTD PMID:12605413 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916
JBrowse link
G Mt1 metallothionein 1 multiple interactions
decreases expression
EXP Ro 31-8220 inhibits the reaction [Cadmium Chloride results in increased expression of MT1 mRNA]; Ro 31-8220 inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]
Ro 31-8220 results in decreased expression of MT1 mRNA
CTD PMID:11551972 NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP Ro 31-8220 inhibits the reaction [deoxynivalenol results in increased expression of NOS2 protein] CTD PMID:32416088 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions ISO Ro 31-8220 inhibits the reaction [DPP3 protein results in increased expression of NQO1 protein]; Ro 31-8220 inhibits the reaction [SQSTM1 protein results in increased expression of NQO1 protein] CTD PMID:17360324 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Nts neurotensin increases activity
multiple interactions
ISO Ro 31-8220 results in increased activity of NTS protein
Ro 31-8220 affects the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]; Tetradecanoylphorbol Acetate inhibits the reaction [Ro 31-8220 results in increased activity of NTS protein]
CTD PMID:18313772 NCBI chr10:102,317,617...102,326,294
Ensembl chr10:102,317,617...102,326,347
JBrowse link
G Ppp1r14a protein phosphatase 1, regulatory inhibitor subunit 14A multiple interactions ISO Ro 31-8220 inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased phosphorylation of PPP1R14A protein] CTD PMID:18986333 NCBI chr 7:28,988,732...28,992,817
Ensembl chr 7:28,988,733...28,993,226
JBrowse link
G Prkca protein kinase C, alpha multiple interactions EXP
ISO
Ro 31-8220 inhibits the reaction [deoxynivalenol affects the localization of PRKCA protein]
Ro 31-8220 promotes the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of and results in decreased phosphorylation of PRKCA protein]
CTD PMID:32416088 PMID:36925031 NCBI chr11:107,824,213...108,237,360
Ensembl chr11:107,824,213...108,234,754
JBrowse link
G Prkce protein kinase C, epsilon multiple interactions EXP Ro 31-8220 inhibits the reaction [deoxynivalenol affects the localization of PRKCE protein] CTD PMID:32416088 NCBI chr17:86,472,631...86,965,347
Ensembl chr17:86,475,213...86,965,347
JBrowse link
G Prkcg protein kinase C, gamma multiple interactions EXP Ro 31-8220 inhibits the reaction [deoxynivalenol affects the localization of PRKCG protein] CTD PMID:32416088 NCBI chr 7:3,352,038...3,379,615
Ensembl chr 7:3,337,704...3,379,615
JBrowse link
G Prkci protein kinase C, iota decreases activity EXP Ro 31-8220 results in decreased activity of PRKCI protein CTD PMID:14511371 NCBI chr 3:31,049,893...31,106,889
Ensembl chr 3:31,049,896...31,107,108
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
Ro 31-8220 inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; Ro 31-8220 inhibits the reaction [NCX 4040 results in increased expression of PTGS2 protein]
Ro 31-8220 inhibits the reaction [deoxynivalenol results in increased expression of PTGS2 protein]
CTD PMID:11854442 PMID:19576865 PMID:32416088 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO Ro 31-8220 inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased expression of RHOA protein modified form] CTD PMID:18986333 NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133
JBrowse link
G Rnf187 ring finger protein 187 multiple interactions
decreases stability
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Ro 31-8220 results in decreased stability of RNF187 protein] CTD PMID:25851810 NCBI chr11:58,823,114...58,829,732
Ensembl chr11:58,823,114...58,829,742
JBrowse link
G Rps6ka5 ribosomal protein S6 kinase, polypeptide 5 decreases activity ISO Ro 31-8220 results in decreased activity of RPS6KA5 protein CTD PMID:15522277 NCBI chr12:100,514,692...100,691,693
Ensembl chr12:100,514,698...100,693,242
JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions ISO Ro 31-8220 inhibits the reaction [Niacin results in increased expression of SCARB1 mRNA] CTD PMID:15037193 NCBI chr 5:125,354,151...125,418,082
Ensembl chr 5:125,354,151...125,418,158
JBrowse link
G Sftpb surfactant associated protein B multiple interactions ISO Ro 31-8220 inhibits the reaction [Adenosine Triphosphate results in increased secretion of SFTPB protein]; Ro 31-8220 inhibits the reaction [Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of SFTPB protein]; Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of SFTPB protein] CTD PMID:11704537 NCBI chr 6:72,281,594...72,291,354
Ensembl chr 6:72,281,594...72,291,354
JBrowse link
G Sftpc surfactant associated protein C multiple interactions ISO Ro 31-8220 inhibits the reaction [Adenosine Triphosphate results in increased secretion of SFTPC protein]; Ro 31-8220 inhibits the reaction [Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of SFTPC protein]; Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of SFTPC protein] CTD PMID:11704537 NCBI chr14:70,758,381...70,761,521
Ensembl chr14:70,758,389...70,761,521
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO Ro 31-8220 inhibits the reaction [SQSTM1 protein results in increased expression of NQO1 protein] CTD PMID:17360324 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Ro 31-8220 inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:16757516 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Ro 31-8220 inhibits the reaction [FCER1A protein results in increased expression of TNF mRNA] CTD PMID:16818790 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 multiple interactions ISO Ro 31-8220 inhibits the reaction [decitabine results in increased expression of TNFSF10 protein] CTD PMID:17283156 NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Ro 31-8220 results in decreased expression of VEGFA mRNA CTD PMID:12590138 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link
SB 415286 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Copper affects the localization of APP protein] CTD PMID:24610780 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Casp3 caspase 3 multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in increased cleavage of CASP3 protein] CTD PMID:33548343 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp8 caspase 8 multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased activity of CASP8 protein]; 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Camptothecin results in increased activity of CASP8 protein]; 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Etoposide results in increased activity of CASP8 protein] CTD PMID:15475000 PMID:15942663 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions
ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of CCND1 mRNA
[3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione co-treated with WNT3A protein] results in increased expression of CCND1 mRNA; bisphenol A inhibits the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of CCND1 mRNA]
[3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in decreased activity of GSK3B protein] inhibits the reaction [Sirolimus results in decreased expression of CCND1 protein]
CTD PMID:15753396 PMID:25381574 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions
ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased phosphorylation of CREB1 protein
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]]; 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein]
CTD PMID:23292070 PMID:29723552 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in decreased activity of GSK3B protein] which results in increased expression of CTNNB1 protein CTD PMID:19159680 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
JBrowse link
G Dbn1 drebrin 1 multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DBN1 protein]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DBN1 protein]] CTD PMID:33548343 NCBI chr13:55,621,241...55,635,874
Ensembl chr13:55,621,242...55,635,924
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein]] CTD PMID:33548343 NCBI chr11:69,908,029...69,938,107
Ensembl chr11:69,907,768...69,938,348
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in increased phosphorylation of DPYSL2 protein]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DBN1 protein]]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein]]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of SYP protein]] CTD PMID:33548343 NCBI chr14:67,040,313...67,148,490
Ensembl chr14:67,040,313...67,148,410
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Camptothecin results in increased expression of and affects the localization of FAS protein]; 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Etoposide results in increased expression of and affects the localization of FAS protein] CTD PMID:15475000 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
decreases activity
ISO
EXP
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Dizocilpine Maleate results in decreased phosphorylation of and results in increased activity of GSK3B protein]; [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in decreased activity of GSK3B protein] inhibits the reaction [Sirolimus results in decreased expression of CCND1 protein]
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased phosphorylation of GSK3B protein]
[3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in decreased activity of GSK3B protein] which results in increased expression of CTNNB1 protein
CTD PMID:15753396 PMID:19159680 PMID:31563592 PMID:33548343 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
JBrowse link
G Gys1 glycogen synthase 1, muscle multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [resveratrol results in increased phosphorylation of GYS1 protein] CTD PMID:23292070 NCBI chr 7:45,084,263...45,106,041
Ensembl chr 7:45,084,268...45,106,043
JBrowse link
G Il6 interleukin 6 multiple interactions EXP 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Cisplatin results in increased expression of IL6 mRNA] CTD PMID:24560772 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 increases expression
multiple interactions
ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of LEF1 mRNA
bisphenol A inhibits the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of LEF1 mRNA]; WNT3A protein promotes the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of LEF1 mRNA]
CTD PMID:25381574 NCBI chr 3:130,903,972...131,018,006
Ensembl chr 3:130,904,120...131,018,005
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions EXP 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Cyclosporine results in increased cleavage of PARP1 protein] CTD PMID:22155090 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [resveratrol results in decreased phosphorylation of RPS6KB1 protein] CTD PMID:23292070 NCBI chr11:86,389,695...86,435,711
Ensembl chr11:86,389,697...86,435,631
JBrowse link
G Syp synaptophysin multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of SYP protein]; DPYSL2 protein affects the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Sevoflurane results in decreased expression of SYP protein]] CTD PMID:33548343 NCBI chr  X:7,504,819...7,519,495
Ensembl chr  X:7,504,710...7,519,495
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Cisplatin results in increased expression of TNF mRNA] CTD PMID:24560772 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Wnt3a wingless-type MMTV integration site family, member 3A multiple interactions ISO [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione co-treated with WNT3A protein] results in increased expression of CCND1 mRNA; WNT3A protein promotes the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of LEF1 mRNA] CTD PMID:25381574 NCBI chr11:59,138,859...59,181,579
Ensembl chr11:59,138,859...59,181,578
JBrowse link
sotrastaurin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Avp arginine vasopressin multiple interactions ISO sotrastaurin inhibits the reaction [Raloxifene Hydrochloride results in decreased expression of AVP mRNA]; sotrastaurin inhibits the reaction [Selective Estrogen Receptor Modulators results in decreased expression of AVP mRNA] CTD PMID:26200092 NCBI chr 2:130,422,540...130,424,508
Ensembl chr 2:130,422,540...130,424,474
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO sotrastaurin inhibits the reaction [Raloxifene Hydrochloride results in increased phosphorylation of MAPK1 protein]; sotrastaurin inhibits the reaction [Selective Estrogen Receptor Modulators results in increased phosphorylation of MAPK1 protein] CTD PMID:26200092 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO sotrastaurin inhibits the reaction [Raloxifene Hydrochloride results in increased phosphorylation of MAPK3 protein]; sotrastaurin inhibits the reaction [Selective Estrogen Receptor Modulators results in increased phosphorylation of MAPK3 protein] CTD PMID:26200092 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Prkcb protein kinase C, beta decreases activity
multiple interactions
ISO sotrastaurin results in decreased activity of PRKCB protein
sotrastaurin inhibits the reaction [docetaxel results in increased phosphorylation of PRKCB protein]
CTD PMID:25634538 NCBI chr 7:121,888,327...122,233,625
Ensembl chr 7:121,887,974...122,233,625
JBrowse link
tetramethrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions
decreases expression
ISO tetramethrin results in decreased activity of [Dihydrotestosterone results in increased activity of AR protein]
tetramethrin results in decreased expression of AR mRNA
CTD PMID:12711008 PMID:16621434 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821
JBrowse link
G Brca1 breast cancer 1, early onset affects binding ISO tetramethrin binds to BRCA1 protein CTD PMID:32278787 NCBI chr11:101,379,587...101,442,808
Ensembl chr11:101,379,590...101,442,781
JBrowse link
G Ces2h carboxylesterase 2H multiple interactions
increases metabolic processing
ISO CES2 protein inhibits the reaction [tetramethrin results in increased activity of NR1I2 protein]
CES2 protein results in increased metabolism of tetramethrin
CTD PMID:19249324 NCBI chr 8:105,727,462...105,747,042
Ensembl chr 8:105,727,485...105,747,810
JBrowse link
G Esr1 estrogen receptor 1 (alpha) decreases expression ISO tetramethrin results in decreased expression of ESR1 protein CTD PMID:16326440 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
JBrowse link
G Esr2 estrogen receptor 2 (beta) increases expression ISO tetramethrin results in increased expression of ESR2 protein CTD PMID:16326440 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
JBrowse link
G Folh1 folate hydrolase 1 decreases expression ISO tetramethrin results in decreased expression of FOLH1 mRNA CTD PMID:12711008 NCBI chr 7:86,365,733...86,425,171
Ensembl chr 7:86,368,185...86,425,151
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions EXP tetramethrin inhibits the reaction [IGF1 protein results in increased import of Calcium] CTD PMID:1550224 PMID:2460452 PMID:2539779 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904
JBrowse link
G Igf2 insulin-like growth factor 2 multiple interactions EXP tetramethrin inhibits the reaction [IGF2 protein results in increased import of Calcium] CTD PMID:2442157 PMID:2539779 NCBI chr 7:142,204,505...142,220,566
Ensembl chr 7:142,204,503...142,220,553
JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO tetramethrin results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602
JBrowse link
G Nkx3-1 NK3 homeobox 1 decreases expression ISO tetramethrin results in decreased expression of NKX3-1 mRNA CTD PMID:12711008 NCBI chr14:69,428,141...69,432,107
Ensembl chr14:69,428,087...69,432,111
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO CES2 protein inhibits the reaction [tetramethrin results in increased activity of NR1I2 protein] CTD PMID:19249324 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO [Diethylhexyl Phthalate co-treated with butylparaben co-treated with tetramethrin co-treated with propylparaben] results in increased activity of NR3C1 protein; [Diethylhexyl Phthalate co-treated with butylparaben co-treated with tetramethrin] results in increased activity of NR3C1 protein; [tetramethrin co-treated with propylparaben] results in increased activity of NR3C1 protein CTD PMID:25448277 NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474
JBrowse link
G S100g S100 calcium binding protein G decreases expression
multiple interactions
ISO tetramethrin results in decreased expression of S100G mRNA
tetramethrin inhibits the reaction [Estradiol results in increased expression of S100G mRNA]
CTD PMID:16326440 NCBI chr  X:161,744,988...161,747,595
Ensembl chr  X:161,744,988...161,747,595
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO tetramethrin binds to SHBG protein CTD PMID:32278787 NCBI chr11:69,501,108...69,508,852
Ensembl chr11:69,505,630...69,508,731
JBrowse link
U-73122 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenergic receptor, alpha 1a multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose] CTD PMID:15550506 NCBI chr14:66,872,705...67,009,549
Ensembl chr14:66,872,700...67,008,617
JBrowse link
G Adra2a adrenergic receptor, alpha 2a multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein] CTD PMID:10742289 NCBI chr19:54,033,690...54,037,413
Ensembl chr19:54,032,582...54,037,413
JBrowse link
G Agt angiotensinogen multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [AGT protein affects the localization of Calcium]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]] CTD PMID:18250367 PMID:21613610 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein] CTD PMID:15177934 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Apoa1 apolipoprotein A-I multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Phosphatidylinositols results in increased expression of APOA1 protein] CTD PMID:19013290 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764
JBrowse link
G Cacna1e calcium channel, voltage-dependent, R type, alpha 1E subunit multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]] CTD PMID:12663092 NCBI chr 1:154,266,552...154,760,374
Ensembl chr 1:154,266,477...154,760,247
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [SK&F 83959 promotes the reaction [CAMK2A protein binds to DRD3 protein]] CTD PMID:19217379 NCBI chr18:61,058,704...61,121,224
Ensembl chr18:61,058,690...61,121,224
JBrowse link
G Casp3 caspase 3 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein] CTD PMID:19927300 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casr calcium-sensing receptor multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [CASR protein results in increased uptake of Calcium] CTD PMID:21562303 NCBI chr16:36,310,947...36,382,605
Ensembl chr16:36,314,058...36,382,503
JBrowse link
G Cck cholecystokinin multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [deoxynivalenol results in increased secretion of CCK protein] CTD PMID:25787141 NCBI chr 9:121,318,890...121,324,728
Ensembl chr 9:121,318,890...121,324,760
JBrowse link
G Ccl26 C-C motif chemokine ligand 26 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [CCL26 protein binds to and results in increased activity of CCR3 protein] CTD PMID:37788752 NCBI chr 5:135,589,302...135,592,423
Ensembl chr 5:135,589,302...135,592,423
JBrowse link
G Ccr3 C-C motif chemokine receptor 3 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [CCL26 protein binds to and results in increased activity of CCR3 protein] CTD PMID:37788752 NCBI chr 9:123,817,799...123,831,729
Ensembl chr 9:123,822,009...123,831,726
JBrowse link
G Cd40 CD40 antigen multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Carbachol results in increased expression of CD40 protein] CTD PMID:16879495 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1, CNS multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium] CTD PMID:18316702 NCBI chr19:8,641,369...8,660,970
Ensembl chr19:8,641,153...8,660,951
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methamphetamine results in increased expression of CREB1 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methamphetamine results in increased expression of CREB1 protein]
CTD PMID:17680988 PMID:33421459 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Quercetin results in increased secretion of CSF2 protein] CTD PMID:18346843 NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Derp2 allergen, Dermatophagoides pteronyssinus results in increased secretion of CXCL8 protein] CTD PMID:30623574 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione affects the reaction [imidacloprid affects the expression of CYP19A1 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione affects the reaction [thiacloprid affects the expression of CYP19A1 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA] CTD PMID:29701941 NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methamphetamine results in increased expression of DLG4 protein] CTD PMID:33421459 NCBI chr11:69,908,029...69,938,107
Ensembl chr11:69,907,768...69,938,348
JBrowse link
G Drd3 dopamine receptor D3 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [SK&F 83959 promotes the reaction [CAMK2A protein binds to DRD3 protein]] CTD PMID:19217379 NCBI chr16:43,574,285...43,646,353
Ensembl chr16:43,574,389...43,643,295
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine] CTD PMID:14759557 PMID:15245872 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466
JBrowse link
G Edn3 endothelin 3 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [EDN3 protein results in increased secretion of Norepinephrine] CTD PMID:14759557 PMID:15245872 NCBI chr 2:174,602,412...174,625,835
Ensembl chr 2:174,602,412...174,625,835
JBrowse link
G Ednrb endothelin receptor type B multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein] CTD PMID:15245872 NCBI chr14:104,052,055...104,081,764
Ensembl chr14:104,052,061...104,081,838
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein] CTD PMID:15177934 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
JBrowse link
G F2 coagulation factor II multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [F2 protein results in increased localization of Calcium] CTD PMID:19814731 NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of FOS mRNA] CTD PMID:19225867 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
JBrowse link
G Gcg glucagon multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [deoxynivalenol results in increased secretion of GCG protein alternative form] CTD PMID:25787141 NCBI chr 2:62,304,874...62,313,997
Ensembl chr 2:62,304,874...62,313,994
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [diphenylditelluride results in increased phosphorylation of GFAP protein] CTD PMID:21879721 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738
JBrowse link
G Gnas GNAS complex locus multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[[6alpha-ethyl-23(S)-methylcholic acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols] CTD PMID:23022524 NCBI chr 2:174,126,113...174,188,537
Ensembl chr 2:174,126,113...174,188,537
JBrowse link
G Gpbar1 G protein-coupled bile acid receptor 1 multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[[6alpha-ethyl-23(S)-methylcholic acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[[Oleanolic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased activity of GNAS protein] which results in increased hydrolysis of Phosphatidylinositols] CTD PMID:23022524 NCBI chr 1:74,316,269...74,318,868
Ensembl chr 1:74,317,709...74,318,783
JBrowse link
G Hspa5 heat shock protein 5 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methamphetamine results in increased expression of HSPA5 protein] CTD PMID:33421459 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [IL1B protein affects the localization of PRKCA protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [IL1B protein results in increased phosphorylation of SRC protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B]]
CTD PMID:19281832 PMID:22214447 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6 interleukin 6 multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [di-n-butyltin results in increased expression of IL6 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [di-n-butyltin results in increased expression of IL6 protein] CTD PMID:24631921 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Ins1 insulin I multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[4-(3-3,4-p-menthadien-(1,8)-yl)olivetol co-treated with Glucose] results in increased secretion of INS1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[O-1602 compound co-treated with Glucose] results in increased secretion of INS1 protein] CTD PMID:31054273 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914
JBrowse link
G Ip6k1 inositol hexaphosphate kinase 1 decreases activity ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione results in decreased activity of IP6K1 protein CTD PMID:29042286 NCBI chr 9:107,879,847...107,925,981
Ensembl chr 9:107,879,700...107,925,981
JBrowse link
G Jun jun proto-oncogene multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of JUN mRNA] CTD PMID:19225867 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
JBrowse link
G Kng1 kininogen 1 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [KNG1 protein inhibits the reaction [Potassium Chloride results in increased secretion of TAC1 protein]]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [KNG1 protein results in increased susceptibility to Capsaicin] CTD PMID:16696851 PMID:17324588 NCBI chr16:22,876,970...22,900,828
Ensembl chr16:22,876,615...22,900,828
JBrowse link
G Lep leptin multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO
EXP
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Permethrin results in increased phosphorylation of MAPK1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [desnitroimidacloprid results in increased phosphorylation of MAPK1 protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Estradiol results in increased activity of MAPK1 protein]
CTD PMID:12460746 PMID:15034929 PMID:15177934 PMID:15355987 PMID:16713447 More... NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO
EXP
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK3 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Permethrin results in increased phosphorylation of MAPK3 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [desnitroimidacloprid results in increased phosphorylation of MAPK3 protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Estradiol results in increased activity of MAPK3 protein]
CTD PMID:12460746 PMID:15034929 PMID:15177934 PMID:15355987 PMID:16713447 More... NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Pilocarpine results in increased activity of MAPK8 protein] CTD PMID:19927300 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Vehicle Emissions results in increased expression of MMP1 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Vehicle Emissions results in increased secretion of MMP1 protein] CTD PMID:21245013 NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047
JBrowse link
G Nefl neurofilament, light polypeptide multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFL protein] CTD PMID:21879721 NCBI chr14:68,321,312...68,326,544
Ensembl chr14:68,321,312...68,326,544
JBrowse link
G Nefm neurofilament, medium polypeptide multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFM protein] CTD PMID:21879721 NCBI chr14:68,356,994...68,362,453
Ensembl chr14:68,320,039...68,362,295
JBrowse link
G Nos1 nitric oxide synthase 1, neuronal multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein] CTD PMID:15245872 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2]] CTD PMID:22214447 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nppa natriuretic peptide type A multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of NPPA mRNA] CTD PMID:15240149 PMID:16714034 NCBI chr 4:148,085,179...148,086,531
Ensembl chr 4:148,085,179...148,086,536
JBrowse link
G Nts neurotensin multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:15177934 NCBI chr10:102,317,617...102,326,294
Ensembl chr10:102,317,617...102,326,347
JBrowse link
G Plcb1 phospholipase C, beta 1 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCB1 protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methamphetamine results in increased expression of PLCB1 mRNA]
CTD PMID:16714034 PMID:33421459 NCBI chr 2:134,628,084...135,317,178
Ensembl chr 2:134,627,987...135,317,178
JBrowse link
G Plcb3 phospholipase C, beta 3 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCB3 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCB3 protein] CTD PMID:16714034 NCBI chr19:6,931,081...6,951,738
Ensembl chr19:6,929,693...6,953,838
JBrowse link
G Plcd1 phospholipase C, delta 1 decreases activity
multiple interactions
EXP
ISO
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione results in decreased activity of PLCD1 protein
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCD1 protein]
CTD PMID:16618758 PMID:16714034 NCBI chr 9:118,900,595...118,922,570
Ensembl chr 9:118,900,595...118,922,570
JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions
decreases expression
ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCG1 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCG1 protein]; [1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione results in decreased expression of PLCG1 protein] which results in decreased abundance of Inositol 1,4,5-Trisphosphate
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [iodixanol results in increased phosphorylation of PLCG1 protein]
CTD PMID:16714034 PMID:16973916 PMID:34774977 NCBI chr 2:160,573,230...160,617,680
Ensembl chr 2:160,573,220...160,617,680
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory inhibitor subunit 1B multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein] CTD PMID:11880652 NCBI chr11:98,239,232...98,248,622
Ensembl chr11:98,239,230...98,248,622
JBrowse link
G Prkca protein kinase C, alpha multiple interactions EXP
ISO
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione promotes the reaction [Corticosterone results in increased activity of PRKCA protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [IL1B protein affects the localization of PRKCA protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methamphetamine results in increased expression of PRKCA mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methamphetamine results in increased expression of PRKCA protein]
CTD PMID:16581232 PMID:19281832 PMID:33421459 NCBI chr11:107,824,213...108,237,360
Ensembl chr11:107,824,213...108,234,754
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer affects the localization of PRKCD protein] CTD PMID:29669290 NCBI chr14:30,317,310...30,348,637
Ensembl chr14:30,317,311...30,348,167
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2]] CTD PMID:22214447 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]] CTD PMID:18250367 NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133
JBrowse link
G Selp selectin, platelet multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased expression of SELP protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione promotes the reaction [resveratrol inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased expression of SELP protein]]; resveratrol promotes the reaction [1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased expression of SELP protein]] CTD PMID:18291361 NCBI chr 1:163,942,833...163,977,595
Ensembl chr 1:163,942,833...163,977,595
JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Chloroquine affects the localization of SLC2A4 protein] CTD PMID:27160165 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014
JBrowse link
G Src Rous sarcoma oncogene multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [IL1B protein results in increased phosphorylation of SRC protein] CTD PMID:19281832 NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782
JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [25-hydroxyprotopanaxadiol results in increased phosphorylation of STK11 protein] CTD PMID:33676887 NCBI chr10:79,951,602...79,966,513
Ensembl chr10:79,951,637...79,966,516
JBrowse link
G Syp synaptophysin multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methamphetamine results in increased expression of SYP protein] CTD PMID:33421459 NCBI chr  X:7,504,819...7,519,495
Ensembl chr  X:7,504,710...7,519,495
JBrowse link
G Tac1 tachykinin 1 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [GR 73632 promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [KNG1 protein inhibits the reaction [Potassium Chloride results in increased secretion of TAC1 protein]] CTD PMID:16696851 PMID:18809416 NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF]] CTD PMID:22214447 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [cinnamaldehyde results in increased activity of TRPA1 protein] CTD PMID:15046718 NCBI chr 1:14,942,868...14,989,086
Ensembl chr 1:14,942,872...14,989,086
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 decreases activity
multiple interactions
EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione results in decreased activity of TRPC6 protein
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Carbachol results in increased activity of TRPC6 protein]
CTD PMID:11179201 PMID:17603544 NCBI chr 9:8,543,868...8,680,753
Ensembl chr 9:8,544,143...8,680,742
JBrowse link
G Trpm8 transient receptor potential cation channel, subfamily M, member 8 multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Menthol results in increased activity of TRPM8] CTD PMID:15046718 NCBI chr 1:88,234,457...88,318,909
Ensembl chr 1:88,205,383...88,317,015
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [GR 73632 results in increased phosphorylation of TRPV1 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein] CTD PMID:18172555 PMID:18809416 NCBI chr11:73,124,975...73,152,148
Ensembl chr11:73,125,118...73,152,068
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] CTD PMID:19281832 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337
JBrowse link
G Vim vimentin multiple interactions ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [diphenylditelluride results in increased phosphorylation of VIM protein] CTD PMID:21879721 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22441
    chemical entity 22440
      group 22288
        inorganic group 21291
          oxo group 20365
            organic oxo compound 20365
              carbonyl compound 20365
                dicarboxylic acids and O-substituted derivatives 13224
                  dicarboxylic acid 13221
                    C4-dicarboxylic acid 1367
                      butenedioic acid 629
                        2-amino-3-(3-oxoprop-1-enyl)but-2-enedioic acid + 0
                        3-carboxyprop-2-enoyl group + 0
                        butenedioyl group + 0
                        enol-oxaloacetic acid 0
                        fumaric acid + 79
                        maleic acid + 589
Path 2
Term Annotations click to browse term
  CHEBI ontology 22441
    subatomic particle 22435
      composite particle 22435
        hadron 22435
          baryon 22435
            nucleon 22435
              atomic nucleus 22435
                atom 22435
                  main group element atom 22321
                    p-block element atom 22321
                      carbon group element atom 22125
                        carbon atom 22058
                          organic molecular entity 22058
                            heteroorganic entity 21705
                              organochalcogen compound 21195
                                organooxygen compound 21038
                                  carbonyl compound 20365
                                    dicarboxylic acids and O-substituted derivatives 13224
                                      dicarboxylic acid 13221
                                        C4-dicarboxylic acid 1367
                                          butenedioic acid 629
                                            2-amino-3-(3-oxoprop-1-enyl)but-2-enedioic acid + 0
                                            3-carboxyprop-2-enoyl group + 0
                                            butenedioyl group + 0
                                            enol-oxaloacetic acid 0
                                            fumaric acid + 79
                                            maleic acid + 589
paths to the root