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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:daprodustat
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Accession:CHEBI:229223 term browser browse the term
Definition:A member of the class of barbiturates that is barbituric acid substituted by cyclohexyl groups at positions 1 and 3, and by a (carboxymethyl)aminocarbonyl group at position 5. It is an inhibitor of hypoxia-inducible factor prolyl hydroxylase developed by GlaxoSmithKline for the treatment of anaemia in patients with chronic kidney disease.
Synonyms:exact_synonym: N-[(1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidin-5-yl)carbonyl]glycine
 related_synonym: Formula=C19H27N3O6;   GSK 1278863;   GSK1278863;   InChI=1S/C19H27N3O6/c23-14(24)11-20-16(25)15-17(26)21(12-7-3-1-4-8-12)19(28)22(18(15)27)13-9-5-2-6-10-13/h12-13,15H,1-11H2,(H,20,25)(H,23,24);   InChIKey=RUEYEZADQJCKGV-UHFFFAOYSA-N;   Jesduvroq;   SMILES=OC(=O)CNC(=O)C1C(=O)N(C2CCCCC2)C(=O)N(C2CCCCC2)C1=O;   daprodustatum;   {[(1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidin-5-yl)carbonyl]amino}acetic acid
 xref: CAS:960539-70-2;   DrugBank:DB11682;   HMDB:HMDB0250863;   KEGG:D10874;   PMID:25343825;   PMID:31640478;   PMID:32880805;   PMID:34739196;   PMID:34824467;   PMID:35191925;   PMID:35281917;   PMID:35355447;   PMID:35380500;   PMID:35534679;   PMID:35628849;   PMID:35639861;   PMID:35643373;   PMID:35983622;   PMID:36181513;   PMID:36195739;   PMID:36372403;   PMID:36565721;   PMID:36577110;   PMID:36577111;   PMID:36577112;   PMID:36739866;   PMID:36780413;   PMID:36868377;   PMID:37026612;   PMID:37116458;   PMID:37125459;   PMID:37156672;   PMID:37516063;   PMID:37637409;   PMID:37885335;   PMID:37926547;   PMID:38261926;   PMID:38412265;   Wikipedia:Daprodustat



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Term Annotations click to browse term
  CHEBI ontology 19879
    role 19850
      application 19693
        anti-anaemic agent 107
          daprodustat 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19879
    subatomic particle 19877
      composite particle 19877
        hadron 19877
          baryon 19877
            nucleon 19877
              atomic nucleus 19877
                atom 19877
                  main group element atom 19816
                    main group molecular entity 19816
                      s-block molecular entity 19651
                        hydrogen molecular entity 19633
                          hydrides 19147
                            inorganic hydride 18160
                              pnictogen hydride 18150
                                nitrogen hydride 18063
                                  azane 17872
                                    ammonia 17871
                                      organic amino compound 17871
                                        amino acid 16064
                                          alpha-amino acid 13935
                                            serine family amino acid 5759
                                              glycine 3327
                                                glycine derivative 3317
                                                  N-acylglycine 30
                                                    daprodustat 0
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