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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 2.1.1.354 ([histone H3]-lysine(4) N-trimethyltransferase) inhibitor
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Accession:CHEBI:228263 term browser browse the term
Definition:An EC 2.1.1.* (methyltransferases) inhibitor that interferes with the action of [histone H3]-lysine(4) N-trimethyltransferase (EC 2.1.1.354).
Synonyms:related_synonym: ASH1L inhibitor;   ASH1L inhibitors;   EC 2.1.1.354 ([histone H3]-lysine(4) N-trimethyltransferase) inhibitors;   EC 2.1.1.354 inhibitor;   EC 2.1.1.354 inhibitors;   KMT2H inhibitor;   KMT2H inhibitors;   KMT3C inhibitor;   KMT3C inhibitors;   KMT3D inhibitor;   KMT3D inhibitors;   KMT3E inhibitor;   KMT3E inhibitors;   MLL5 inhibitor;   MLL5 inhibitors;   PRDM9 inhibitor;   PRDM9 inhibitors;   SMYD1 inhibitor;   SMYD1 inhibitors;   SMYD2 inhibitor;   SMYD2 inhibitors;   SMYD3 inhibitor;   SMYD3 inhibitors;   [histone H3]-lysine(4) N-trimethyltransferase inhibitor;   [histone H3]-lysine(4) N-trimethyltransferase inhibitors


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LLY-507 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD36 CD36 molecule (CD36 blood group) multiple interactions ISO [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of CD36 mRNA CTD PMID:29718165 NCBI chr 7:80,602,207...80,679,274
Ensembl chr 7:80,369,575...80,679,277 		JBrowse link
G IFNG interferon gamma multiple interactions ISO [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of CD36 mRNA; [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of MARCO mRNA; [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of MMP9 mRNA; [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of MSR1 mRNA; [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in increased expression of IL6 mRNA; [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in increased expression of TNF mRNA CTD PMID:29718165 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in increased expression of IL6 mRNA CTD PMID:29718165 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G MARCO macrophage receptor with collagenous structure multiple interactions ISO [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of MARCO mRNA CTD PMID:29718165 NCBI chr 2:118,942,194...118,994,660
Ensembl chr 2:118,942,194...118,994,660 		JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions ISO [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of MMP9 mRNA CTD PMID:29718165 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MSR1 macrophage scavenger receptor 1 multiple interactions ISO [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of MSR1 mRNA CTD PMID:29718165 NCBI chr 8:16,107,881...16,192,651
Ensembl chr 8:16,107,878...16,567,490 		JBrowse link
G SMYD2 SET and MYND domain containing 2 multiple interactions EXP LLY-507 binds to and results in decreased activity of SMYD2 protein CTD PMID:25825497 NCBI chr 1:214,281,159...214,337,131
Ensembl chr 1:214,281,102...214,337,131 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in increased expression of TNF mRNA CTD PMID:29718165 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26798
    role 26626
      biological role 26605
        biochemical role 25857
          enzyme inhibitor 22908
            EC 2.* (transferase) inhibitor 16133
              EC 2.1.* (C1-transferase) inhibitor 3742
                EC 2.1.1.* (methyltransferases) inhibitor 725
                  EC 2.1.1.354 ([histone H3]-lysine(4) N-trimethyltransferase) inhibitor 8
                    AZ505 0
                    LLY-507 8
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