CHEBI ONTOLOGY - ANNOTATIONS |
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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
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Term: | benzodiazepine |
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Accession: | CHEBI:22720
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browse the term
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Definition: | A group of heterocyclic compounds with a core structure containing a benzene ring fused to a diazepine ring. |
Synonyms: | related_synonym: | benzodiazepines |
| alt_id: | MESH:D001569 |
| xref_mesh: | MESH:D001569 |
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G |
Gabre |
gamma-aminobutyric acid type A receptor subunit epsilon |
decreases response to substance |
EXP |
GABRE protein results in decreased susceptibility to Benzodiazepines |
CTD |
PMID:11691872 |
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NCBI chr X:150,060,035...150,078,773
Ensembl chr X:150,060,040...150,078,693
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Gabrg2 |
gamma-aminobutyric acid type A receptor subunit gamma 2 |
affects response to substance |
ISO |
GABRG2 protein affects the susceptibility to Benzodiazepines |
CTD |
PMID:7644489 |
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NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases chemical synthesis increases glucuronidation multiple interactions increases abundance |
ISO |
CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam CYP3A4 protein results in increased glucuronidation of 1-hydroxymethylmidazolam [[3-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[5-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[6-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[6-methylflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[7-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[alpha-naphthoflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[artemetin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[beta-Naphthoflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[chrysin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[eupatilin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[flavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[galangin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[nobiletin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[sinensetin analog results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[sinensetin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[tangeretin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [CYP3A4 protein results in increased glucuronidation of 1-hydroxymethylmidazolam] which results in increased abundance of 1-hydroxymethylmidazolam glucuronide; [CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased abundance of 1-hydroxymethylmidazolam; [CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased chemical synthesis of 1-hydroxymethylmidazolam; [L 754394 results in decreased activity of CYP3A4 protein] which results in decreased chemical synthesis of 1-hydroxymethylmidazolam; acacetin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Apigenin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; CYP3A4 protein inhibits the reaction [Rifampin results in decreased chemical synthesis of 1-hydroxymethylmidazolam]; diosmetin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; erdafitinib inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; flavanone promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; flavone promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; galangin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased abundance of 1-hydroxymethylmidazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Luteolin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; NADP deficiency inhibits the reaction [erdafitinib inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]]; Rifampin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Rifampin promotes the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Verapamil inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam] |
CTD |
PMID:10997946 PMID:12401345 PMID:12695342 PMID:18191104 PMID:20233841 PMID:21053930 PMID:21915887 PMID:23850985 PMID:26958860 PMID:27485346 PMID:30087611 PMID:31756459 PMID:34189909 More...
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
increases chemical synthesis multiple interactions |
ISO |
CYP3A5 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam [CYP3A5 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; erdafitinib inhibits the reaction [[CYP3A5 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam] |
CTD |
PMID:18191104 PMID:26958860 PMID:34189909 |
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NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Tspo |
translocator protein |
affects binding |
EXP |
1-hydroxymethylmidazolam binds to TSPO protein; 1-hydroxymethylmidazolam metabolite binds to TSPO protein |
CTD |
PMID:7603229 |
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NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
[CYP3A4 protein results in increased glucuronidation of 1-hydroxymethylmidazolam] which results in increased abundance of 1-hydroxymethylmidazolam glucuronide |
CTD |
PMID:27485346 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases chemical synthesis multiple interactions |
ISO |
CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam [CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased abundance of 4-hydroxymidazolam; [CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam; acacetin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; Apigenin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; CYP3A4 protein inhibits the reaction [Rifampin results in decreased chemical synthesis of 4-hydroxymidazolam]; diosmetin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam]; flavanone inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; flavone inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; galangin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam]; Luteolin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam]; Rifampin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam] |
CTD |
PMID:12695342 PMID:18191104 PMID:21053930 PMID:27485346 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
increases chemical synthesis multiple interactions |
ISO |
CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam diosmetin inhibits the reaction [CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam]; Luteolin inhibits the reaction [CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam] |
CTD |
PMID:18191104 |
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NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Crh |
corticotropin releasing hormone |
multiple interactions |
EXP |
adinazolam inhibits the reaction [CRF protein results in increased secretion of beta-Endorphin] |
CTD |
PMID:1480515 |
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NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
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Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
decreases methylation multiple interactions |
ISO |
CYP2C19 protein results in decreased methylation of adinazolam Omeprazole inhibits the reaction [CYP2C19 protein results in decreased methylation of adinazolam] |
CTD |
PMID:9600717 |
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NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
decreases methylation multiple interactions |
ISO |
CYP3A4 protein results in decreased methylation of adinazolam Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased methylation of adinazolam]; Troleandomycin inhibits the reaction [CYP3A4 protein results in decreased methylation of adinazolam] |
CTD |
PMID:9600717 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Htr2a |
5-hydroxytryptamine receptor 2A |
decreases expression |
EXP |
adinazolam results in decreased expression of HTR2A protein |
CTD |
PMID:1664741 |
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NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
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Trh |
thyrotropin releasing hormone |
multiple interactions |
EXP |
adinazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] |
CTD |
PMID:2845442 |
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NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637
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Trhr |
thyrotropin releasing hormone receptor |
multiple interactions |
EXP |
adinazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] |
CTD |
PMID:2845442 |
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NCBI chr 7:75,348,672...75,393,310
Ensembl chr 7:75,348,672...75,393,309
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
affects chemical synthesis |
ISO |
CYP3A4 protein affects the chemical synthesis of alpha-hydroxyalprazolam |
CTD |
PMID:12196913 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
affects chemical synthesis |
EXP |
CYP3A23-3A1 protein affects the chemical synthesis of alpha-hydroxyalprazolam |
CTD |
PMID:12196913 |
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NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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G |
Capn1 |
calpain 1 |
multiple interactions |
ISO |
[Caffeine co-treated with Alprazolam] promotes the reaction [Calcium results in increased activity of CAPN1 protein] |
CTD |
PMID:19490937 |
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NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
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Casp3 |
caspase 3 |
multiple interactions |
ISO |
[Caffeine co-treated with Alprazolam] results in increased cleavage of CASP3 protein |
CTD |
PMID:19490937 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Ctsb |
cathepsin B |
multiple interactions |
ISO |
[Caffeine co-treated with Alprazolam] results in increased secretion of CTSB protein |
CTD |
PMID:19490937 |
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NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions affects metabolic processing |
ISO |
CYP3A4 protein binds to and affects the metabolism of Alprazolam CYP3A4 protein affects the metabolism of Alprazolam |
CTD |
PMID:12196913 PMID:15856409 PMID:16042670 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
affects metabolic processing |
EXP |
CYP3A23-3A1 protein affects the metabolism of Alprazolam |
CTD |
PMID:12196913 |
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NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
increases hydroxylation |
ISO |
CYP3A5 protein results in increased hydroxylation of Alprazolam |
CTD |
PMID:15903124 |
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NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Il2 |
interleukin 2 |
decreases expression |
ISO |
Alprazolam results in decreased expression of IL2 protein |
CTD |
PMID:1624223 |
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NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Lhb |
luteinizing hormone subunit beta |
increases secretion |
ISO |
Alprazolam results in increased secretion of LHB protein |
CTD |
PMID:7883836 |
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NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
[Caffeine co-treated with Alprazolam] results in increased activity of PARP1 protein |
CTD |
PMID:19490937 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Plcb1 |
phospholipase C beta 1 |
decreases expression |
EXP |
Alprazolam results in decreased expression of PLCB1 mRNA; Alprazolam results in decreased expression of PLCB1 protein |
CTD |
PMID:12527476 |
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NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869
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Ppia |
peptidylprolyl isomerase A |
increases hydroxylation |
ISO |
PPIA protein results in increased hydroxylation of Alprazolam |
CTD |
PMID:15806426 |
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NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601
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G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
Alprazolam inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
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NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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G |
Trh |
thyrotropin releasing hormone |
multiple interactions |
EXP |
Alprazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] |
CTD |
PMID:2845442 |
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NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637
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G |
Trhr |
thyrotropin releasing hormone receptor |
multiple interactions |
EXP |
Alprazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] |
CTD |
PMID:2845442 |
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NCBI chr 7:75,348,672...75,393,310
Ensembl chr 7:75,348,672...75,393,309
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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
decreases activity |
ISO |
Chlordiazepoxide results in decreased activity of ABCB11 protein |
CTD |
PMID:20829430 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Gabre |
gamma-aminobutyric acid type A receptor subunit epsilon |
decreases response to substance |
EXP |
GABRE protein results in decreased susceptibility to Chlordiazepoxide |
CTD |
PMID:11691872 |
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NCBI chr X:150,060,035...150,078,773
Ensembl chr X:150,060,040...150,078,693
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G |
Trh |
thyrotropin releasing hormone |
multiple interactions |
EXP |
Chlordiazepoxide inhibits the reaction [TRH protein modified form binds to TRHR protein] |
CTD |
PMID:2845442 |
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NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637
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G |
Trhr |
thyrotropin releasing hormone receptor |
multiple interactions |
EXP |
Chlordiazepoxide inhibits the reaction [TRH protein modified form binds to TRHR protein] |
CTD |
PMID:2845442 |
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NCBI chr 7:75,348,672...75,393,310
Ensembl chr 7:75,348,672...75,393,309
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
affects response to substance |
EXP |
ABCC2 protein affects the susceptibility to clobazam |
CTD |
PMID:22982618 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
F2 |
coagulation factor II, thrombin |
multiple interactions |
ISO |
[clobazam co-treated with Phenytoin] results in increased expression of [F2 protein binds to SERPINC1 protein] |
CTD |
PMID:16376047 |
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NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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G |
Sele |
selectin E |
multiple interactions |
ISO |
[clobazam co-treated with Phenytoin] results in increased expression of SELE protein |
CTD |
PMID:16376047 |
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NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
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G |
Serpinc1 |
serpin family C member 1 |
multiple interactions |
ISO |
[clobazam co-treated with Phenytoin] results in increased expression of [F2 protein binds to SERPINC1 protein] |
CTD |
PMID:16376047 |
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NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
EXP |
Clonazepam results in increased expression of BAX protein |
CTD |
PMID:17456340 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
increases expression |
EXP |
Clonazepam results in increased expression of BCL2 protein |
CTD |
PMID:17456340 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
increases activity |
EXP |
Clonazepam results in increased activity of CYP2B1 protein |
CTD |
PMID:1372805 |
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NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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G |
Dcx |
doublecortin |
decreases expression |
EXP |
Clonazepam results in decreased expression of DCX protein |
CTD |
PMID:19437554 |
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NCBI chr X:107,430,767...107,573,612
Ensembl chr X:107,430,767...107,507,476
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G |
Ephx1 |
epoxide hydrolase 1 |
increases activity |
EXP |
Clonazepam results in increased activity of EPHX1 protein |
CTD |
PMID:1372805 |
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NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
Clonazepam binds to and results in increased activity of NR1I2 protein |
CTD |
PMID:20024649 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Aars1 |
alanyl-tRNA synthetase 1 |
increases expression |
ISO |
Clozapine results in increased expression of AARS1 protein |
CTD |
PMID:34122009 |
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NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147
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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
decreases activity |
ISO |
Clozapine results in decreased activity of ABCB11 protein |
CTD |
PMID:22646477 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions decreases activity |
EXP ISO |
Clozapine inhibits the reaction [Bromocriptine results in increased expression of ABCB1 protein]; Clozapine inhibits the reaction [N-n-propylnorapomorphine results in increased expression of ABCB1 protein]; Clozapine inhibits the reaction [Quinpirole results in increased expression of ABCB1 protein] Clozapine results in decreased activity of ABCB1 protein |
CTD |
PMID:9111066 PMID:16810505 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcb1b |
ATP-binding cassette, sub-family B member 1B |
multiple interactions |
EXP |
Clozapine inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; Clozapine inhibits the reaction [N-n-propylnorapomorphine results in increased activity of ABCB1B promoter]; Clozapine inhibits the reaction [Quinpirole results in increased activity of ABCB1B promoter] |
CTD |
PMID:9111066 |
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NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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G |
Abce1 |
ATP binding cassette subfamily E member 1 |
increases expression |
ISO |
Clozapine results in increased expression of ABCE1 protein |
CTD |
PMID:34122009 |
|
NCBI chr19:28,205,566...28,230,489
Ensembl chr19:28,205,555...28,230,489
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G |
Abcg1 |
ATP binding cassette subfamily G member 1 |
increases expression |
ISO |
Clozapine results in increased expression of ABCG1 mRNA |
CTD |
PMID:17346280 |
|
NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
multiple interactions |
ISO |
Clozapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone] |
CTD |
PMID:18834354 |
|
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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G |
Ablim2 |
actin binding LIM protein family, member 2 |
increases expression |
ISO |
Clozapine results in increased expression of ABLIM2 mRNA |
CTD |
PMID:17346280 |
|
NCBI chr14:74,865,409...74,990,334
Ensembl chr14:74,866,281...74,990,334
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G |
Acat2 |
acetyl-CoA acetyltransferase 2 |
increases expression |
ISO |
Clozapine results in increased expression of ACAT2 mRNA |
CTD |
PMID:17052361 |
|
NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821
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G |
Acot2 |
acyl-CoA thioesterase 2 |
increases expression |
ISO |
Clozapine results in increased expression of ACOT2 protein |
CTD |
PMID:34122009 |
|
NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245
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G |
Acot7 |
acyl-CoA thioesterase 7 |
decreases expression |
ISO |
Clozapine results in decreased expression of ACOT7 protein |
CTD |
PMID:34122009 |
|
NCBI chr 5:162,686,562...162,779,309
Ensembl chr 5:162,684,645...162,779,309
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G |
Acox1 |
acyl-CoA oxidase 1 |
multiple interactions |
EXP |
[Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of ACOX1 protein; [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of ACOX1 mRNA |
CTD |
PMID:23226405 |
|
NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232
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G |
Actb |
actin, beta |
decreases expression |
ISO |
Clozapine results in decreased expression of ACTB protein |
CTD |
PMID:34122009 |
|
NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
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G |
Actbl2 |
actin, beta-like 2 |
increases expression |
ISO |
Clozapine results in increased expression of ACTBL2 protein |
CTD |
PMID:34122009 |
|
NCBI chr 2:42,858,020...42,860,767
Ensembl chr 2:42,858,020...42,860,767
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G |
Actr3 |
actin related protein 3 |
decreases expression |
ISO |
Clozapine results in decreased expression of ACTR3 protein |
CTD |
PMID:34122009 |
|
NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124
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G |
Actr5 |
actin related protein 5 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in increased expression of ACTR5 protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:147,282,461...147,295,870
Ensembl chr 3:147,282,624...147,296,110
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G |
Adam1a |
ADAM metallopeptidase domain 1a |
decreases expression |
EXP |
Clozapine results in decreased expression of ADAM1A mRNA |
CTD |
PMID:16715494 |
|
NCBI chr12:35,017,433...35,020,300
Ensembl chr12:35,017,315...35,020,311
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G |
Adamts12 |
ADAM metallopeptidase with thrombospondin type 1 motif, 12 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of ADAMTS12 protein |
CTD |
PMID:34122009 |
|
NCBI chr 2:60,032,873...60,327,629
Ensembl chr 2:60,032,873...60,327,629
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G |
Adcy5 |
adenylate cyclase 5 |
affects response to substance multiple interactions |
ISO |
ADCY5 protein affects the susceptibility to Clozapine SCH 23390 inhibits the reaction [ADCY5 protein affects the susceptibility to Clozapine] |
CTD |
PMID:12223546 |
|
NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974
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G |
Adh5 |
alcohol dehydrogenase 5 (class III), chi polypeptide |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in increased expression of ADH5 protein |
CTD |
PMID:34122009 |
|
NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
decreases expression increases expression multiple interactions |
ISO EXP |
Clozapine results in decreased expression of ADIPOQ protein Clozapine results in increased expression of ADIPOQ protein Clozapine results in increased expression of ADIPOQ mRNA Berberine inhibits the reaction [Clozapine results in increased expression of ADIPOQ mRNA] |
CTD |
PMID:17933447 PMID:18162013 PMID:20564506 |
|
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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G |
Adora2a |
adenosine A2a receptor |
decreases expression |
ISO |
Clozapine results in decreased expression of ADORA2A mRNA |
CTD |
PMID:17266109 |
|
NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
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G |
Adra1a |
adrenoceptor alpha 1A |
multiple interactions |
EXP |
Clozapine binds to and results in decreased activity of ADRA1A protein |
CTD |
PMID:16545797 |
|
NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
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G |
Agpat1 |
1-acylglycerol-3-phosphate O-acyltransferase 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of AGPAT1 mRNA |
CTD |
PMID:14647396 |
|
NCBI chr20:4,135,955...4,144,880
Ensembl chr20:4,135,957...4,145,278
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G |
Agt |
angiotensinogen |
multiple interactions |
ISO |
Clozapine inhibits the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]; Clozapine promotes the reaction [Raclopride promotes the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]] |
CTD |
PMID:11549694 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Aimp1 |
aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 |
increases expression |
ISO |
Clozapine results in increased expression of AIMP1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 2:221,151,907...221,175,458
Ensembl chr 2:221,151,904...221,175,728
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G |
Ak1 |
adenylate kinase 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of AK1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041
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G |
Akt1 |
AKT serine/threonine kinase 1 |
increases expression decreases expression increases phosphorylation |
ISO EXP |
Clozapine results in increased expression of AKT1 mRNA; Clozapine results in increased expression of AKT1 protein Clozapine results in decreased expression of AKT1 mRNA Clozapine results in increased phosphorylation of AKT1 protein |
CTD |
PMID:15860345 PMID:19440698 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Akt2 |
AKT serine/threonine kinase 2 |
increases expression |
EXP |
Clozapine results in increased expression of AKT2 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
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G |
Alb |
albumin |
multiple interactions affects binding |
EXP ISO |
Clozapine results in decreased expression of and results in decreased reduction of ALB protein Clozapine binds to ALB protein [[[stearic acid binds to ALB protein] which affects the susceptibility to Clozapine] which affects the reduction of Cysteine] which affects the activity of ALB protein; [[stearic acid binds to ALB protein] which affects the susceptibility to Clozapine] which affects the reduction of Cysteine; [stearic acid binds to ALB protein] which affects the susceptibility to Clozapine; stearic acid inhibits the reaction [Clozapine binds to ALB protein] |
CTD |
PMID:31400341 |
|
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
increases expression |
ISO |
Clozapine results in increased expression of ALDH1A1 mRNA |
CTD |
PMID:17266109 |
|
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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G |
Aldoa |
aldolase, fructose-bisphosphate A |
increases expression |
EXP |
Clozapine results in increased expression of ALDOA mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
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G |
Aldob |
aldolase, fructose-bisphosphate B |
increases expression decreases expression |
ISO |
Clozapine results in increased expression of ALDOB protein Clozapine results in decreased expression of ALDOB protein |
CTD |
PMID:34122009 PMID:36482696 |
|
NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116
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G |
Aldoc |
aldolase, fructose-bisphosphate C |
decreases expression increases expression |
ISO EXP |
Clozapine results in decreased expression of ALDOC mRNA Clozapine results in increased expression of ALDOC mRNA |
CTD |
PMID:15860345 PMID:16465460 |
|
NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066
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G |
Alpp |
alkaline phosphatase, placental |
multiple interactions |
ISO |
Clozapine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]; Clozapine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA] |
CTD |
PMID:16036225 |
|
NCBI chr 9:87,765,846...87,768,606
Ensembl chr 9:87,765,860...87,768,606
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G |
Alyref |
Aly/REF export factor |
decreases expression |
ISO |
Clozapine results in decreased expression of ALYREF protein |
CTD |
PMID:34122009 |
|
NCBI chr10:105,871,424...105,875,076
Ensembl chr10:105,871,306...105,875,069
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G |
Anxa1 |
annexin A1 |
decreases expression |
ISO |
Clozapine results in decreased expression of ANXA1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
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G |
Anxa5 |
annexin A5 |
decreases expression |
ISO |
Clozapine results in decreased expression of ANXA5 protein |
CTD |
PMID:34122009 |
|
NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369
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G |
Anxa6 |
annexin A6 |
decreases expression |
ISO |
Clozapine results in decreased expression of ANXA6 protein |
CTD |
PMID:34122009 |
|
NCBI chr10:39,101,395...39,156,483
Ensembl chr10:39,097,109...39,156,433
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G |
Ap1s1 |
adaptor related protein complex 1 subunit sigma 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of AP1S1 mRNA |
CTD |
PMID:17175557 |
|
NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713
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G |
Ap2b1 |
adaptor related protein complex 2 subunit beta 1 |
increases expression |
EXP |
Clozapine results in increased expression of AP2B1 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr10:68,099,397...68,205,023
Ensembl chr10:68,099,547...68,205,013
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G |
Ap3b1 |
adaptor related protein complex 3 subunit beta 1 |
increases expression |
ISO |
Clozapine results in increased expression of AP3B1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 2:25,600,069...25,800,937
Ensembl chr 2:25,600,040...25,800,935
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G |
Apoa5 |
apolipoprotein A5 |
affects response to substance |
EXP |
APOA5 gene polymorphism affects the susceptibility to Clozapine |
CTD |
PMID:17726453 |
|
NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816
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G |
Apod |
apolipoprotein D |
increases expression |
ISO |
Clozapine results in increased expression of APOD mRNA; Clozapine results in increased expression of APOD protein |
CTD |
PMID:11158250 PMID:14647396 PMID:17266109 |
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NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305
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G |
App |
amyloid beta precursor protein |
increases expression |
ISO |
Clozapine results in increased expression of APP protein |
CTD |
PMID:36482696 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Arc |
activity-regulated cytoskeleton-associated protein |
decreases expression |
EXP |
Clozapine results in decreased expression of ARC mRNA |
CTD |
PMID:18208916 |
|
NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
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G |
Arhgef9 |
Cdc42 guanine nucleotide exchange factor 9 |
decreases expression |
ISO |
Clozapine results in decreased expression of ARHGEF9 mRNA |
CTD |
PMID:17266109 |
|
NCBI chr X:59,919,560...60,077,538
Ensembl chr X:59,920,870...60,077,513
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G |
Arl8a |
ARF like GTPase 8A |
decreases expression |
ISO |
Clozapine results in decreased expression of ARL8A protein |
CTD |
PMID:34122009 |
|
NCBI chr13:46,585,845...46,594,851
Ensembl chr13:46,585,845...46,594,851
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G |
Armt1 |
acidic residue methyltransferase 1 |
increases expression |
ISO |
Clozapine results in increased expression of ARMT1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:40,894,558...40,918,302
Ensembl chr 1:40,894,550...40,918,302
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G |
Arpc4 |
actin related protein 2/3 complex, subunit 4 |
affects expression |
ISO |
Clozapine affects the expression of ARPC4 mRNA |
CTD |
PMID:14647396 |
|
NCBI chr 4:146,522,255...146,532,784
Ensembl chr 4:146,522,176...146,532,785
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G |
Asah1 |
N-acylsphingosine amidohydrolase 1 |
increases expression |
ISO |
Clozapine results in increased expression of ASAH1 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
|
NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233
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G |
Asns |
asparagine synthetase (glutamine-hydrolyzing) |
increases expression |
ISO |
Clozapine results in increased expression of ASNS mRNA; Clozapine results in increased expression of ASNS protein |
CTD |
PMID:15342952 PMID:17175557 PMID:36482696 |
|
NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
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G |
Asph |
aspartate-beta-hydroxylase |
increases expression |
ISO |
Clozapine results in increased expression of ASPH protein |
CTD |
PMID:34122009 |
|
NCBI chr 5:22,601,581...22,814,107
Ensembl chr 5:22,603,486...22,813,876
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G |
Ass1 |
argininosuccinate synthase 1 |
increases expression |
ISO |
Clozapine results in increased expression of ASS1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903
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G |
Atad3a |
ATPase family, AAA domain containing 3A |
decreases expression |
ISO |
Clozapine results in decreased expression of ATAD3A protein |
CTD |
PMID:34122009 |
|
NCBI chr 5:166,350,302...166,370,492
Ensembl chr 5:166,350,304...166,370,482
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G |
Atp2a3 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 |
increases expression |
ISO |
Clozapine results in increased expression of ATP2A3 protein |
CTD |
PMID:34122009 |
|
NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748
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G |
Atp5f1b |
ATP synthase F1 subunit beta |
decreases expression |
EXP |
Clozapine results in decreased expression of ATP5F1B protein |
CTD |
PMID:19441803 |
|
NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273
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G |
Atp5pb |
ATP synthase peripheral stalk-membrane subunit b |
increases expression |
ISO |
Clozapine results in increased expression of ATP5PB protein |
CTD |
PMID:34122009 |
|
NCBI chr 2:193,424,138...193,435,418
Ensembl chr 2:193,424,047...193,435,418
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G |
Atp6v1a |
ATPase H+ transporting V1 subunit A |
decreases expression |
ISO |
Clozapine results in decreased expression of ATP6V1A protein |
CTD |
PMID:34122009 |
|
NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694
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G |
Atp6v1b1 |
ATPase H+ transporting V1 subunit B1 |
decreases expression |
ISO |
Clozapine results in decreased expression of ATP6V1B1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 4:116,223,799...116,242,475
Ensembl chr 4:116,223,799...116,242,475
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G |
Atp6v1b2 |
ATPase H+ transporting V1 subunit B2 |
decreases expression |
EXP ISO |
Clozapine results in decreased expression of ATP6V1B2 protein |
CTD |
PMID:19441803 PMID:34122009 |
|
NCBI chr16:20,617,515...20,641,651
Ensembl chr16:20,617,518...20,641,745
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G |
Atxn10 |
ataxin 10 |
increases expression |
ISO |
Clozapine results in increased expression of ATXN10 protein |
CTD |
PMID:34122009 |
|
NCBI chr 7:116,441,768...116,565,093
Ensembl chr 7:116,441,613...116,565,087
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G |
Axin2 |
axin 2 |
decreases expression |
EXP |
Clozapine results in decreased expression of AXIN2 mRNA |
CTD |
PMID:16715494 |
|
NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231
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G |
Bace2 |
beta-secretase 2 |
increases expression |
ISO |
Clozapine results in increased expression of BACE2 protein |
CTD |
PMID:36482696 |
|
NCBI chr11:36,707,447...36,789,550
Ensembl chr11:36,707,458...36,789,546
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions decreases expression |
ISO EXP |
Clozapine results in increased expression of BAX mRNA; Clozapine results in increased expression of BAX protein CSF3 protein inhibits the reaction [Clozapine results in increased expression of BAX mRNA] Clozapine results in decreased expression of BAX protein |
CTD |
PMID:16160616 PMID:17069804 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Baz1b |
bromodomain adjacent to zinc finger domain, 1B |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of BAZ1B protein |
CTD |
PMID:34122009 |
|
NCBI chr12:21,431,985...21,489,956
Ensembl chr12:21,431,985...21,490,426
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G |
Bcar1 |
BCAR1 scaffold protein, Cas family member |
decreases expression |
ISO |
Clozapine results in decreased expression of BCAR1 protein |
CTD |
PMID:34122009 |
|
NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907
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G |
Bcl2 |
BCL2, apoptosis regulator |
increases expression |
EXP |
Clozapine results in increased expression of BCL2 mRNA; Clozapine results in increased expression of BCL2 protein |
CTD |
PMID:15126120 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l14 |
Bcl2-like 14 |
decreases expression |
ISO |
Clozapine results in decreased expression of BCL2L14 protein |
CTD |
PMID:34122009 |
|
NCBI chr 4:167,217,561...167,258,723
Ensembl chr 4:167,219,871...167,258,086
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G |
Bdnf |
brain-derived neurotrophic factor |
decreases expression increases expression |
EXP |
Clozapine results in decreased expression of BDNF mRNA Clozapine results in increased expression of BDNF mRNA; Clozapine results in increased expression of BDNF protein |
CTD |
PMID:11488957 PMID:12478621 PMID:17442489 |
|
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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|
G |
Bet1l |
Bet1 golgi vesicular membrane trafficking protein-like |
decreases expression |
EXP |
Clozapine results in decreased expression of BET1L mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 1:195,931,407...195,935,072
Ensembl chr 1:195,931,411...195,935,040
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|
G |
Bik |
BCL2-interacting killer |
multiple interactions increases expression |
ISO |
CSF3 protein inhibits the reaction [Clozapine results in increased expression of BIK mRNA] |
CTD |
PMID:16160616 |
|
NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296
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|
G |
Bptf |
bromodomain PHD finger transcription factor |
decreases expression |
ISO |
Clozapine results in decreased expression of BPTF mRNA |
CTD |
PMID:14647396 |
|
NCBI chr10:91,980,279...92,082,731
Ensembl chr10:91,982,758...92,082,769
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|
G |
Bzw1 |
basic leucine zipper and W2 domains 1 |
increases expression |
ISO |
Clozapine results in increased expression of BZW1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 9:59,930,672...59,944,468
Ensembl chr 9:59,930,744...59,944,430
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|
G |
Cacna1a |
calcium voltage-gated channel subunit alpha1 A |
decreases expression |
ISO EXP |
Clozapine results in decreased expression of CACNA1A mRNA |
CTD |
PMID:14647396 PMID:16715494 |
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NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225
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G |
Calcoco1 |
calcium binding and coiled coil domain 1 |
increases expression |
ISO |
Clozapine results in increased expression of CALCOCO1 protein |
CTD |
PMID:36482696 |
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NCBI chr 7:133,834,705...133,849,515
Ensembl chr 7:133,834,707...133,849,422
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G |
Calm2 |
calmodulin 2 |
increases expression |
EXP |
Clozapine results in increased expression of CALM2 mRNA |
CTD |
PMID:19289156 |
|
NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287 Ensembl chr15:7,091,567...7,104,287
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G |
Calr |
calreticulin |
decreases expression |
ISO |
Clozapine results in decreased expression of CALR protein |
CTD |
PMID:34122009 |
|
NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
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G |
Calu |
calumenin |
decreases expression |
ISO |
Clozapine results in decreased expression of CALU protein |
CTD |
PMID:34122009 |
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NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593
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G |
Camk2a |
calcium/calmodulin-dependent protein kinase II alpha |
decreases expression increases expression |
ISO EXP |
Clozapine results in decreased expression of CAMK2A mRNA Clozapine results in increased expression of CAMK2A mRNA Clozapine results in decreased expression of CAMK2A protein |
CTD |
PMID:15860345 PMID:17266109 PMID:19289156 |
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NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
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G |
Camk2b |
calcium/calmodulin-dependent protein kinase II beta |
decreases expression |
EXP |
Clozapine results in decreased expression of CAMK2B mRNA |
CTD |
PMID:15860345 |
|
NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
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G |
Camk2d |
calcium/calmodulin-dependent protein kinase II delta |
decreases expression |
EXP |
Clozapine results in decreased expression of CAMK2D mRNA |
CTD |
PMID:15860345 |
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NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178
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G |
Camk4 |
calcium/calmodulin-dependent protein kinase IV |
increases expression decreases expression |
EXP |
Clozapine results in increased expression of CAMK4 mRNA Clozapine results in decreased expression of CAMK4 protein |
CTD |
PMID:15860345 PMID:19289156 |
|
NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487
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G |
Camkk1 |
calcium/calmodulin-dependent protein kinase kinase 1 |
decreases expression |
EXP |
Clozapine results in decreased expression of CAMKK1 protein |
CTD |
PMID:19289156 |
|
NCBI chr10:57,637,335...57,660,498
Ensembl chr10:57,637,391...57,660,498
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G |
Camkk2 |
calcium/calmodulin-dependent protein kinase kinase 2 |
decreases expression |
EXP |
Clozapine results in decreased expression of CAMKK2 protein |
CTD |
PMID:19289156 |
|
NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279
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G |
Canx |
calnexin |
decreases expression |
ISO |
Clozapine results in decreased expression of CANX protein |
CTD |
PMID:34122009 |
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NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821
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G |
Cars1 |
cysteinyl-tRNA synthetase 1 |
increases expression |
ISO |
Clozapine results in increased expression of CARS1 protein |
CTD |
PMID:34122009 |
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NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941
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G |
Cartpt |
CART prepropeptide |
decreases expression |
EXP |
Clozapine results in decreased expression of CARTPT mRNA |
CTD |
PMID:14696011 |
|
NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713
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G |
Casp1 |
caspase 1 |
increases activity |
ISO |
Clozapine results in increased activity of CASP1 protein |
CTD |
PMID:34935985 |
|
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
ISO EXP |
Clozapine results in increased activity of CASP3 protein Palmitic Acid promotes the reaction [Clozapine results in increased activity of CASP3 protein] |
CTD |
PMID:22700542 PMID:24709159 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp7 |
caspase 7 |
increases activity multiple interactions |
ISO |
Clozapine results in increased activity of CASP7 protein Palmitic Acid promotes the reaction [Clozapine results in increased activity of CASP7 protein] |
CTD |
PMID:22700542 |
|
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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G |
Cat |
catalase |
multiple interactions |
ISO |
Clozapine inhibits the reaction [Corticosterone results in increased activity of CAT protein]; Clozapine inhibits the reaction [Lipopolysaccharides inhibits the reaction [Corticosterone results in increased activity of CAT protein]] |
CTD |
PMID:14730115 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccar1 |
cell division cycle and apoptosis regulator 1 |
increases expression |
ISO |
Clozapine results in increased expression of CCAR1 protein |
CTD |
PMID:34122009 |
|
NCBI chr20:30,685,916...30,728,531
Ensembl chr20:30,685,916...30,728,526
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G |
Ccdc47 |
coiled-coil domain containing 47 |
increases expression multiple interactions |
ISO |
Clozapine results in increased expression of CCDC47 protein [Cuprizone co-treated with Clozapine] results in increased expression of CCDC47 protein |
CTD |
PMID:34122009 |
|
NCBI chr10:91,130,303...91,148,829
Ensembl chr10:91,130,303...91,148,881
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G |
Cck |
cholecystokinin |
multiple interactions increases expression |
EXP |
Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK protein] Clozapine results in increased expression of CCK mRNA |
CTD |
PMID:10974607 PMID:16567023 |
|
NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
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G |
Cckbr |
cholecystokinin B receptor |
increases expression |
ISO |
Clozapine results in increased expression of CCKBR mRNA |
CTD |
PMID:17266109 |
|
NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881
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G |
Ccl1 |
C-C motif chemokine ligand 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of CCL1 mRNA |
CTD |
PMID:17346280 |
|
NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159
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G |
Ccnd1 |
cyclin D1 |
decreases expression |
EXP |
Clozapine results in decreased expression of CCND1 mRNA |
CTD |
PMID:15860345 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccnd3 |
cyclin D3 |
increases expression |
EXP |
Clozapine results in increased expression of CCND3 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
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G |
Ccnl1 |
cyclin L1 |
increases expression |
EXP |
Clozapine results in increased expression of CCNL1 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 2:150,184,865...150,199,524
Ensembl chr 2:150,184,798...150,197,368
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G |
Cct7 |
chaperonin containing TCP1 subunit 7 |
decreases expression |
ISO |
Clozapine results in decreased expression of CCT7 protein |
CTD |
PMID:34122009 |
|
NCBI chr 4:117,989,232...118,006,478
Ensembl chr 4:117,989,232...118,006,580
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G |
Cd276 |
Cd276 molecule |
decreases expression |
ISO |
Clozapine results in decreased expression of CD276 protein |
CTD |
PMID:34122009 |
|
NCBI chr 8:58,937,751...58,968,082
Ensembl chr 8:58,937,751...58,968,380
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G |
Cd63 |
Cd63 molecule |
increases expression |
ISO |
Clozapine results in increased expression of CD63 protein |
CTD |
PMID:36482696 |
|
NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178
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G |
Cdipt |
CDP-diacylglycerol--inositol 3-phosphatidyltransferase |
increases expression |
ISO |
Clozapine results in increased expression of CDIPT protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:181,583,098...181,587,409
Ensembl chr 1:181,583,141...181,587,408
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G |
Cdk4 |
cyclin-dependent kinase 4 |
increases expression |
EXP |
Clozapine results in increased expression of CDK4 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Cdk5 |
cyclin-dependent kinase 5 |
increases expression |
EXP |
Clozapine results in increased expression of CDK5 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
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G |
Cdk5r1 |
cyclin-dependent kinase 5 regulatory subunit 1 |
increases expression |
ISO |
Clozapine results in increased expression of CDK5R1 mRNA |
CTD |
PMID:17266109 |
|
NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
multiple interactions increases expression |
ISO |
Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA protein] Clozapine results in increased expression of CEBPA mRNA; Clozapine results in increased expression of CEBPA protein |
CTD |
PMID:20564506 |
|
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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G |
Cenpv |
centromere protein V |
increases expression |
ISO |
Clozapine results in increased expression of CENPV protein |
CTD |
PMID:34122009 |
|
NCBI chr10:47,214,479...47,228,552
Ensembl chr10:47,214,490...47,228,761
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G |
Cfap210 |
cilia and flagella associated protein 210 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in increased expression of CFAP210 protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:54,520,455...54,554,677
Ensembl chr 3:54,520,458...54,554,607
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G |
Chchd2 |
coiled-coil-helix-coiled-coil-helix domain containing 2 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in increased expression of CHCHD2 protein |
CTD |
PMID:34122009 |
|
NCBI chr12:26,828,738...26,834,762
Ensembl chr12:26,828,736...26,834,755
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G |
Chd4 |
chromodomain helicase DNA binding protein 4 |
decreases expression |
ISO |
Clozapine results in decreased expression of CHD4 protein |
CTD |
PMID:34122009 |
|
NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541
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G |
Chga |
chromogranin A |
decreases expression increases expression |
EXP |
Clozapine results in decreased expression of CHGA mRNA Clozapine results in increased expression of CHGA mRNA |
CTD |
PMID:12437575 |
|
NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398
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G |
Chl1 |
cell adhesion molecule L1-like |
decreases expression |
ISO |
Clozapine results in decreased expression of CHL1 mRNA |
CTD |
PMID:14647396 |
|
NCBI chr 4:136,291,504...136,505,830
Ensembl chr 4:136,291,463...136,503,265
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G |
Chn1 |
chimerin 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of CHN1 mRNA |
CTD |
PMID:14647396 |
|
NCBI chr 3:58,509,822...58,676,462
Ensembl chr 3:58,510,536...58,676,490
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G |
Chordc1 |
cysteine and histidine rich domain containing 1 |
increases expression |
ISO |
Clozapine results in increased expression of CHORDC1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 8:15,374,356...15,398,436
Ensembl chr 8:15,374,471...15,399,162
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G |
Chrm1 |
cholinergic receptor, muscarinic 1 |
affects binding increases expression multiple interactions |
ISO EXP |
Clozapine analog binds to CHRM1 protein; Clozapine binds to CHRM1 protein Clozapine results in increased expression of CHRM1 protein Clozapine inhibits the reaction [Dextroamphetamine results in decreased expression of CHRM1 protein] |
CTD |
PMID:11997696 PMID:16983399 PMID:18806925 |
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NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356
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G |
Ckap4 |
cytoskeleton-associated protein 4 |
increases expression |
ISO |
Clozapine results in increased expression of CKAP4 protein |
CTD |
PMID:34122009 |
|
NCBI chr 7:19,230,814...19,238,914
Ensembl chr 7:19,230,203...19,238,914
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G |
Clic1 |
chloride intracellular channel 1 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of CLIC1 protein |
CTD |
PMID:34122009 |
|
NCBI chr20:3,764,867...3,773,711
Ensembl chr20:3,761,461...3,773,712
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G |
Clic4 |
chloride intracellular channel 4 |
increases expression |
ISO |
Clozapine results in increased expression of CLIC4 protein |
CTD |
PMID:34122009 |
|
NCBI chr 5:147,453,702...147,513,455
Ensembl chr 5:147,453,712...147,513,452
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G |
Clock |
clock circadian regulator |
affects response to substance |
ISO |
CLOCK gene SNP affects the susceptibility to Clozapine |
CTD |
PMID:15331141 |
|
NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400
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G |
Clta |
clathrin, light chain A |
decreases expression |
EXP |
Clozapine results in decreased expression of CLTA mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 5:58,244,253...58,263,480
Ensembl chr 5:58,245,442...58,263,472
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G |
Cltb |
clathrin, light chain B |
decreases expression |
EXP |
Clozapine results in decreased expression of CLTB mRNA |
CTD |
PMID:15860345 |
|
NCBI chr17:10,001,512...10,019,201
Ensembl chr17:10,001,513...10,019,169
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G |
Cnp |
2',3'-cyclic nucleotide 3' phosphodiesterase |
decreases expression increases expression |
ISO |
Clozapine results in decreased expression of CNP mRNA Clozapine results in decreased expression of CNP protein Clozapine results in increased expression of CNP mRNA |
CTD |
PMID:17266109 PMID:34122009 |
|
NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720
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G |
Coil |
coilin |
increases expression |
EXP |
Clozapine results in increased expression of COIL mRNA |
CTD |
PMID:16715494 |
|
NCBI chr10:73,789,077...73,810,378
Ensembl chr10:73,789,488...73,810,393
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G |
Col5a2 |
collagen type V alpha 2 chain |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in increased expression of COL5A2 protein |
CTD |
PMID:34122009 |
|
NCBI chr 9:47,448,741...47,598,134
Ensembl chr 9:47,448,736...47,598,154
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G |
Comt |
catechol-O-methyltransferase |
multiple interactions affects response to substance increases response to substance |
EXP ISO |
[tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine] COMT protein affects the susceptibility to Clozapine COMT gene polymorphism results in increased susceptibility to Clozapine |
CTD |
PMID:15190105 PMID:17123785 |
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NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
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G |
Cops3 |
COP9 signalosome subunit 3 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of COPS3 protein |
CTD |
PMID:34122009 |
|
NCBI chr10:44,618,115...44,652,807
Ensembl chr10:44,618,115...44,641,597
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G |
Coro1b |
coronin 1B |
decreases expression |
ISO |
Clozapine results in decreased expression of CORO1B protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:201,442,977...201,448,416
Ensembl chr 1:201,443,014...201,448,416
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G |
Cplx2 |
complexin 2 |
decreases expression |
ISO |
Clozapine results in decreased expression of CPLX2 mRNA |
CTD |
PMID:17266109 |
|
NCBI chr17:10,219,577...10,292,835
Ensembl chr17:10,222,347...10,293,855
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G |
Cpn1 |
carboxypeptidase N subunit 1 |
increases expression |
EXP |
Clozapine results in increased expression of CPN1 mRNA |
CTD |
PMID:16715494 |
|
NCBI chr 1:242,844,575...242,873,465
Ensembl chr 1:242,844,212...242,873,465
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G |
Cpne1 |
copine 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of CPNE1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:144,587,531...144,629,911
Ensembl chr 3:144,588,995...144,598,636
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G |
Cpt2 |
carnitine palmitoyltransferase 2 |
multiple interactions |
EXP |
[Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of CPT2 protein; [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of CPT2 mRNA |
CTD |
PMID:23226405 |
|
NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions decreases phosphorylation |
ISO |
Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of CREB1 protein] Clozapine results in decreased phosphorylation of CREB1 protein |
CTD |
PMID:12871586 |
|
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Crh |
corticotropin releasing hormone |
decreases expression |
ISO |
Clozapine results in decreased expression of CRH mRNA |
CTD |
PMID:16205782 |
|
NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
|
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G |
Crhbp |
corticotropin releasing hormone binding protein |
decreases expression |
EXP |
Clozapine results in decreased expression of CRHBP mRNA |
CTD |
PMID:16715494 |
|
NCBI chr 2:26,692,403...26,704,710
Ensembl chr 2:26,692,403...26,704,710
|
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G |
Crp |
C-reactive protein |
increases expression |
ISO |
Clozapine results in increased expression of CRP protein |
CTD |
PMID:17685758 |
|
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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G |
Csf3 |
colony stimulating factor 3 |
multiple interactions |
ISO |
CSF3 protein inhibits the reaction [Clozapine results in increased expression of BAX mRNA]; CSF3 protein inhibits the reaction [Clozapine results in increased expression of BIK mRNA]; CSF3 protein inhibits the reaction [Clozapine results in increased expression of TP53 mRNA] |
CTD |
PMID:16160616 |
|
NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
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|
G |
Csnk2a1 |
casein kinase 2 alpha 1 |
decreases expression |
EXP |
Clozapine results in decreased expression of CSNK2A1 mRNA |
CTD |
PMID:16715494 |
|
NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696
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G |
Cst3 |
cystatin C |
increases expression |
ISO |
Clozapine results in increased expression of CST3 mRNA |
CTD |
PMID:14647396 |
|
NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822
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G |
Cstf1 |
cleavage stimulation factor subunit 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of CSTF1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:161,144,522...161,156,294
Ensembl chr 3:161,144,548...161,156,300
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G |
Cstf2 |
cleavage stimulation factor subunit 2 |
decreases expression |
ISO |
Clozapine results in decreased expression of CSTF2 protein |
CTD |
PMID:34122009 |
|
NCBI chr X:97,253,559...97,279,476
Ensembl chr X:97,253,586...97,279,476
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G |
Ctbp1 |
C-terminal binding protein 1 |
increases expression |
ISO |
Clozapine results in increased expression of CTBP1 protein |
CTD |
PMID:34122009 |
|
NCBI chr14:77,455,580...77,482,821
Ensembl chr14:77,455,696...77,482,821
|
|
G |
Ctnnb1 |
catenin beta 1 |
increases expression multiple interactions |
EXP |
Clozapine results in increased expression of CTNNB1 protein DRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein] |
CTD |
PMID:16144542 |
|
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
|
|
G |
Ctrl |
chymotrypsin-like |
increases expression |
EXP |
Clozapine results in increased expression of CTRL mRNA |
CTD |
PMID:16715494 |
|
NCBI chr19:33,827,279...33,829,129
Ensembl chr19:33,827,229...33,833,626
|
|
G |
Ctsk |
cathepsin K |
increases expression |
EXP |
Clozapine results in increased expression of CTSK mRNA |
CTD |
PMID:16715494 |
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NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
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G |
Cttn |
cortactin |
increases expression |
ISO |
Clozapine results in increased expression of CTTN protein |
CTD |
PMID:34122009 |
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NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164
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G |
Cul2 |
cullin 2 |
increases expression |
ISO |
Clozapine results in increased expression of CUL2 protein |
CTD |
PMID:34122009 |
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NCBI chr17:54,169,093...54,210,197
Ensembl chr17:54,169,086...54,209,968
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G |
Cul3 |
cullin 3 |
increases expression |
ISO |
Clozapine results in increased expression of CUL3 protein |
CTD |
PMID:34122009 |
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NCBI chr 9:81,592,641...81,670,428
Ensembl chr 9:81,592,641...81,670,462
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
decreases expression decreases secretion multiple interactions increases secretion |
ISO EXP |
Clozapine results in decreased expression of CXCL1 mRNA Clozapine results in decreased secretion of CXCL1 protein belnacasan inhibits the reaction [Clozapine results in increased secretion of CXCL1 protein] |
CTD |
PMID:17346280 PMID:34935985 PMID:36482696 |
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NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
decreases secretion |
ISO |
Clozapine results in decreased secretion of CXCL10 protein |
CTD |
PMID:36482696 |
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NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
decreases expression decreases secretion |
ISO |
Clozapine results in decreased expression of CXCL1 mRNA Clozapine results in decreased secretion of CXCL1 protein |
CTD |
PMID:17346280 PMID:36482696 |
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NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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G |
Cxhxorf49 |
similar to human chromosome X open reading frame 49 |
increases expression |
ISO |
Clozapine results in increased expression of CXORF49 protein |
CTD |
PMID:34122009 |
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NCBI chr X:66,911,430...66,915,407
Ensembl chr X:66,911,431...66,915,293
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G |
Cyb5b |
cytochrome b5 type B |
increases expression |
EXP |
Clozapine results in increased expression of CYB5B mRNA |
CTD |
PMID:19441803 |
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NCBI chr19:35,062,871...35,096,741
Ensembl chr19:35,062,813...35,098,249
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G |
Cyb5r1 |
cytochrome b5 reductase 1 |
increases expression |
ISO |
Clozapine results in increased expression of CYB5R1 protein |
CTD |
PMID:34122009 |
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NCBI chr13:45,849,017...45,855,458
Ensembl chr13:45,849,091...45,855,458
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions decreases activity increases metabolic processing |
EXP ISO |
Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] Clozapine results in decreased activity of CYP1A1 protein CYP1A1 protein results in increased metabolism of Clozapine |
CTD |
PMID:18493746 PMID:18809730 PMID:33814510 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases response to substance multiple interactions increases metabolic processing increases expression affects metabolic processing affects response to substance decreases metabolic processing |
ISO EXP |
CYP1A2 gene SNP results in decreased susceptibility to Clozapine Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein] CYP1A2 protein results in increased metabolism of Clozapine Clozapine results in increased expression of CYP1A2 mRNA CYP1A2 gene polymorphism affects the metabolism of Clozapine; CYP1A2 protein affects the metabolism of Clozapine; CYP1A2 protein polymorphism affects the metabolism of Clozapine [Ciprofloxacin results in decreased activity of CYP1A2 protein] which results in increased abundance of Clozapine; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine; Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; Smoke affects the reaction [CYP1A2 gene polymorphism affects the metabolism of Clozapine]; Smoke promotes the reaction [CYP1A2 protein results in increased metabolism of Clozapine] CYP1A2 gene SNP affects the susceptibility to Clozapine; CYP1A2 protein affects the susceptibility to Clozapine CYP1A2 gene SNP results in increased metabolism of Clozapine; CYP1A2 protein results in increased metabolism of Clozapine CYP1A2 gene SNP results in decreased metabolism of Clozapine |
CTD |
PMID:11151749 PMID:11763009 PMID:12919186 PMID:12969762 PMID:15206669 PMID:15286053 PMID:15883149 PMID:15949157 PMID:16044115 PMID:18493746 PMID:18809730 PMID:23397584 PMID:27320963 More...
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases metabolic processing decreases activity |
ISO |
CYP1B1 protein results in increased metabolism of Clozapine Clozapine results in decreased activity of CYP1B1 protein |
CTD |
PMID:18809730 PMID:33814510 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
multiple interactions increases metabolic processing |
ISO |
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine CYP2C19 protein results in increased metabolism of Clozapine |
CTD |
PMID:18809730 PMID:23397584 PMID:27320963 |
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NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
increases metabolic processing |
ISO |
CYP2C8 protein results in increased metabolism of Clozapine |
CTD |
PMID:18809730 PMID:27320963 |
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
affects metabolic processing increases metabolic processing multiple interactions |
ISO |
CYP2D6 protein affects the metabolism of Clozapine CYP2D6 protein results in increased metabolism of Clozapine [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine |
CTD |
PMID:15286053 PMID:18809730 PMID:23397584 PMID:27320963 |
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NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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G |
Cyp2j4 |
cytochrome P450, family 2, subfamily j, polypeptide 4 |
increases metabolic processing |
ISO |
CYP2J2 protein results in increased metabolism of Clozapine |
CTD |
PMID:18809730 |
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NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases metabolic processing affects metabolic processing multiple interactions |
ISO |
CYP3A4 protein results in increased metabolism of Clozapine CYP3A4 protein affects the metabolism of Clozapine [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine; Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]] |
CTD |
PMID:15286053 PMID:18809730 PMID:21402137 PMID:23397584 PMID:27320963 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
increases metabolic processing |
ISO |
CYP3A5 protein results in increased metabolism of Clozapine |
CTD |
PMID:18809730 |
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NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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G |
Dab1 |
DAB adaptor protein 1 |
increases expression |
EXP |
Clozapine results in increased expression of DAB1 mRNA |
CTD |
PMID:19359144 |
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NCBI chr 5:118,392,953...119,513,625
Ensembl chr 5:119,140,533...119,510,552
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G |
Dab2 |
DAB adaptor protein 2 |
increases expression |
ISO |
Clozapine results in increased expression of DAB2 protein |
CTD |
PMID:36482696 |
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NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476
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G |
Daglb |
diacylglycerol lipase, beta |
increases expression |
ISO |
Clozapine results in increased expression of DAGLB protein |
CTD |
PMID:36482696 |
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NCBI chr12:11,059,732...11,102,170
Ensembl chr12:11,059,732...11,102,154
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G |
Dcaf6 |
DDB1 and CUL4 associated factor 6 |
decreases expression |
ISO |
Clozapine results in decreased expression of DCAF6 mRNA |
CTD |
PMID:14647396 |
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NCBI chr13:77,626,257...77,727,645
Ensembl chr13:77,626,307...77,727,512
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G |
Dclk1 |
doublecortin-like kinase 1 |
increases expression |
ISO EXP |
Clozapine results in increased expression of DCLK1 mRNA |
CTD |
PMID:15860345 PMID:18797397 |
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NCBI chr 2:139,417,234...139,710,956
Ensembl chr 2:139,417,163...139,710,956
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G |
Ddc |
dopa decarboxylase |
multiple interactions increases expression |
ISO |
Clozapine results in increased expression of and results in increased activity of DDC protein Clozapine results in increased expression of DDC mRNA |
CTD |
PMID:16415089 |
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NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
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G |
Ddx46 |
DEAD-box helicase 46 |
increases expression |
ISO |
Clozapine results in increased expression of DDX46 protein |
CTD |
PMID:34122009 |
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NCBI chr17:8,942,070...8,988,440
Ensembl chr17:8,944,454...8,988,439
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G |
Dennd10 |
DENN domain containing 10 |
increases expression |
EXP |
Clozapine results in increased expression of DENND10 mRNA |
CTD |
PMID:16715494 |
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NCBI chr 1:259,950,955...259,974,459
Ensembl chr 1:259,950,866...259,974,455
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G |
Depp1 |
DEPP autophagy regulator 1 |
increases expression |
ISO |
Clozapine results in increased expression of DEPP1 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
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NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542
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G |
Dgcr6 |
DiGeorge syndrome critical region gene 6 |
decreases expression |
ISO |
Clozapine results in decreased expression of DGCR6 protein |
CTD |
PMID:34122009 |
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NCBI chr11:82,927,725...82,932,823
Ensembl chr11:82,927,725...82,932,823
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G |
Dgka |
diacylglycerol kinase, alpha |
decreases expression |
EXP |
Clozapine results in decreased expression of DGKA mRNA |
CTD |
PMID:15860345 |
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NCBI chr 7:1,148,734...1,175,324
Ensembl chr 7:1,148,735...1,175,110
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G |
Dhcr24 |
24-dehydrocholesterol reductase |
increases expression |
ISO |
Clozapine results in increased expression of DHCR24 protein |
CTD |
PMID:34122009 |
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NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137
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G |
Dhcr7 |
7-dehydrocholesterol reductase |
increases expression |
ISO |
Clozapine results in increased expression of DHCR7 mRNA |
CTD |
PMID:17052361 |
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NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
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G |
Dhx30 |
DExH-box helicase 30 |
increases expression |
ISO |
Clozapine results in increased expression of DHX30 protein |
CTD |
PMID:34122009 |
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NCBI chr 8:110,064,751...110,096,954
Ensembl chr 8:110,064,752...110,097,381
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G |
Dhx38 |
DEAH-box helicase 38 |
decreases expression |
ISO |
Clozapine results in decreased expression of DHX38 protein |
CTD |
PMID:34122009 |
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NCBI chr19:37,512,893...37,530,135
Ensembl chr19:37,512,891...37,530,140
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G |
Disc1 |
DISC1 scaffold protein |
decreases response to substance affects response to substance |
ISO |
DISC1 gene mutant form results in decreased susceptibility to Clozapine DISC1 protein affects the susceptibility to Clozapine |
CTD |
PMID:20531374 |
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NCBI chr19:53,014,201...53,223,617
Ensembl chr19:53,014,616...53,219,778
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G |
Dlat |
dihydrolipoamide S-acetyltransferase |
decreases expression increases expression |
EXP ISO |
Clozapine results in decreased expression of DLAT mRNA Clozapine results in increased expression of DLAT protein |
CTD |
PMID:15860345 PMID:34122009 |
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NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479 Ensembl chr 1:50,978,051...51,004,479
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G |
Dlg2 |
discs large MAGUK scaffold protein 2 |
increases expression |
ISO |
Clozapine results in increased expression of DLG2 protein |
CTD |
PMID:34122009 |
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NCBI chr 1:144,451,653...146,503,949
Ensembl chr 1:144,451,472...146,499,475
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G |
Dlst |
dihydrolipoamide S-succinyltransferase |
decreases expression |
ISO |
Clozapine results in decreased expression of DLST protein |
CTD |
PMID:34122009 |
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NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296
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G |
Dnah11 |
dynein, axonemal, heavy chain 11 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of DNAH11 protein |
CTD |
PMID:34122009 |
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NCBI chr 6:138,839,175...139,155,554
Ensembl chr 6:138,839,177...139,155,536
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G |
Dnaja3 |
DnaJ heat shock protein family (Hsp40) member A3 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in increased expression of DNAJA3 protein |
CTD |
PMID:34122009 |
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NCBI chr10:10,854,732...10,880,171
Ensembl chr10:10,854,732...10,880,161
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G |
Dnajb11 |
DnaJ heat shock protein family (Hsp40) member B11 |
increases expression |
ISO |
Clozapine results in increased expression of DNAJB11 protein |
CTD |
PMID:34122009 |
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NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407
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G |
Dpf1 |
double PHD fingers 1 |
affects expression |
ISO |
Clozapine affects the expression of DPF1 mRNA |
CTD |
PMID:14647396 |
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NCBI chr 1:84,602,212...84,615,954
Ensembl chr 1:84,602,336...84,615,950
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G |
Dpp3 |
dipeptidylpeptidase 3 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of DPP3 protein |
CTD |
PMID:34122009 |
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NCBI chr 1:202,204,683...202,228,501
Ensembl chr 1:202,204,693...202,228,541
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G |
Dpysl3 |
dihydropyrimidinase-like 3 |
decreases expression |
ISO |
Clozapine results in decreased expression of DPYSL3 protein |
CTD |
PMID:34122009 |
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NCBI chr18:35,374,427...35,480,228
Ensembl chr18:35,377,181...35,480,157
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G |
Dpysl4 |
dihydropyrimidinase-like 4 |
decreases expression |
ISO |
Clozapine results in decreased expression of DPYSL4 protein |
CTD |
PMID:34122009 |
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NCBI chr 1:193,883,039...193,898,916
Ensembl chr 1:193,883,106...193,898,914
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G |
Dr1 |
down-regulator of transcription 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of DR1 protein |
CTD |
PMID:34122009 |
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NCBI chr14:1,458,223...1,469,578
Ensembl chr14:1,458,223...1,469,638
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G |
Drd1 |
dopamine receptor D1 |
affects binding decreases expression affects response to substance |
ISO EXP |
Clozapine binds to DRD1 protein Clozapine results in decreased expression of DRD1 mRNA Clozapine analog binds to DRD1 protein DRD1 gene polymorphism affects the susceptibility to Clozapine; DRD1 protein affects the susceptibility to Clozapine |
CTD |
PMID:1352677 PMID:9723970 PMID:11997696 PMID:17092969 PMID:17266109 |
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NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
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G |
Drd2 |
dopamine receptor D2 |
multiple interactions affects binding affects response to substance decreases expression increases response to substance |
ISO EXP |
[Clozapine co-treated with DRD2 gene polymorphism] results in increased secretion of PRL protein Clozapine binds to DRD2 protein DRD2 protein affects the susceptibility to Clozapine Clozapine results in decreased expression of DRD2 mRNA Clozapine analog binds to DRD2 protein; Clozapine binds to DRD2 protein [Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein; Bromocriptine promotes the reaction [Clozapine results in decreased expression of DRD2 mRNA]; Clozapine binds to and results in decreased activity of DRD2 protein; Clozapine promotes the reaction [Dopamine binds to DRD2 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3A protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein] [Clozapine co-treated with Bromocriptine] results in decreased expression of DRD2 mRNA Clozapine binds to DRD2 protein alternative form DRD2 gene SNP results in increased susceptibility to Clozapine DRD2 gene affects the susceptibility to Clozapine; DRD2 gene polymorphism affects the susceptibility to Clozapine |
CTD |
PMID:1352677 PMID:9723970 PMID:11997696 PMID:12476322 PMID:15286066 PMID:15716360 PMID:15781964 PMID:15830237 PMID:16033416 PMID:16144542 PMID:16278074 PMID:17266109 PMID:20375926 More...
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NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
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G |
Drd3 |
dopamine receptor D3 |
affects response to substance multiple interactions decreases response to substance |
ISO |
DRD3 protein affects the susceptibility to Clozapine DRD3 protein affects the reaction [Clozapine results in increased expression of FOSB protein alternative form] DRD3 gene polymorphism results in decreased susceptibility to Clozapine |
CTD |
PMID:15579174 PMID:20029384 |
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NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
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G |
Drd4 |
dopamine receptor D4 |
affects binding multiple interactions affects response to substance |
ISO EXP |
Clozapine binds to DRD4 protein Clozapine binds to Drd4 protein Clozapine inhibits the reaction [Dopamine results in increased activity of DRD4 protein] Clozapine analog binds to DRD4 protein DRD4 gene polymorphism affects the susceptibility to Clozapine |
CTD RGD |
PMID:11997696 PMID:16223700 PMID:31323226 PMID:8078498 |
RGD:7248459 |
NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
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G |
Drp2 |
dystrophin related protein 2 |
increases expression |
EXP |
Clozapine results in increased expression of DRP2 mRNA alternative form |
CTD |
PMID:16715494 |
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NCBI chr X:97,607,577...97,658,117
Ensembl chr X:97,607,719...97,655,684
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G |
Dtnbp1 |
dystrobrevin binding protein 1 |
increases response to substance affects response to substance |
ISO |
DTNBP1 gene polymorphism results in increased susceptibility to Clozapine DTNBP1 protein affects the susceptibility to Clozapine |
CTD |
PMID:19369910 |
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NCBI chr17:19,685,218...19,776,668
Ensembl chr17:19,685,215...19,776,661
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G |
Dusp1 |
dual specificity phosphatase 1 |
decreases expression |
EXP |
Clozapine results in decreased expression of DUSP1 mRNA |
CTD |
PMID:15860345 |
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NCBI chr10:16,680,478...16,683,275
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G |
Dusp6 |
dual specificity phosphatase 6 |
decreases expression |
EXP |
Clozapine results in decreased expression of DUSP6 mRNA |
CTD |
PMID:15860345 |
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NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
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G |
Dvl3 |
dishevelled segment polarity protein 3 |
increases expression multiple interactions |
EXP |
Clozapine results in increased expression of DVL3 protein DRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein] |
CTD |
PMID:16144542 |
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NCBI chr11:80,365,446...80,382,641
Ensembl chr11:80,366,117...80,382,462
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G |
Dync1li1 |
dynein cytoplasmic 1 light intermediate chain 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of DYNC1LI1 protein |
CTD |
PMID:34122009 |
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NCBI chr 8:114,376,649...114,410,297
Ensembl chr 8:114,376,662...114,410,934
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G |
Dync1li2 |
dynein, cytoplasmic 1 light intermediate chain 2 |
decreases expression |
ISO |
Clozapine results in decreased expression of DYNC1LI2 protein |
CTD |
PMID:34122009 |
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NCBI chr19:531,783...554,670
Ensembl chr19:531,812...554,670
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G |
Edc4 |
enhancer of mRNA decapping 4 |
increases expression |
ISO |
Clozapine results in increased expression of EDC4 protein |
CTD |
PMID:34122009 |
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NCBI chr19:33,774,062...33,786,054
Ensembl chr19:33,774,055...33,787,758
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G |
Eef1a2 |
eukaryotic translation elongation factor 1 alpha 2 |
increases expression |
ISO |
Clozapine results in increased expression of EEF1A2 protein |
CTD |
PMID:34122009 |
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NCBI chr 3:168,265,893...168,275,071
Ensembl chr 3:168,195,357...168,275,071
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G |
Eef1d |
eukaryotic translation elongation factor 1 delta |
decreases expression |
ISO |
Clozapine results in decreased expression of EEF1D protein |
CTD |
PMID:34122009 |
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NCBI chr 7:107,581,930...107,596,735
Ensembl chr 7:107,581,930...107,608,799
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G |
Egr1 |
early growth response 1 |
decreases expression |
EXP |
Clozapine results in decreased expression of EGR1 mRNA; Clozapine results in decreased expression of EGR1 protein |
CTD |
PMID:17028028 PMID:18208916 |
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NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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G |
Egr2 |
early growth response 2 |
affects expression decreases expression |
ISO EXP |
Clozapine affects the expression of EGR2 mRNA Clozapine results in decreased expression of EGR2 protein |
CTD |
PMID:17028028 PMID:19401217 |
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NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
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G |
Egr3 |
early growth response 3 |
affects response to substance |
ISO |
EGR3 protein affects the susceptibility to Clozapine |
CTD |
PMID:17637609 |
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NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627
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G |
Eif2s3 |
eukaryotic translation initiation factor 2 subunit gamma |
increases expression |
ISO |
Clozapine results in increased expression of EIF2S3 protein |
CTD |
PMID:34122009 |
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NCBI chr X:58,916,513...58,939,923
Ensembl chr X:58,917,490...58,940,686
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G |
Eif3c |
eukaryotic translation initiation factor 3, subunit C |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of EIF3C protein |
CTD |
PMID:34122009 |
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NCBI chr 1:181,134,604...181,152,489
Ensembl chr 1:181,134,604...181,152,493
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G |
Eif3j |
eukaryotic translation initiation factor 3, subunit J |
increases expression |
ISO |
Clozapine results in increased expression of EIF3J protein |
CTD |
PMID:34122009 |
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NCBI chr 3:108,985,103...109,007,341
Ensembl chr 3:108,985,118...109,007,953
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G |
Eif3m |
eukaryotic translation initiation factor 3, subunit M |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in increased expression of EIF3M protein |
CTD |
PMID:34122009 |
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NCBI chr 3:91,424,754...91,442,358
Ensembl chr 3:91,416,325...91,442,392
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G |
Eif4a3 |
eukaryotic translation initiation factor 4A3 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of EIF4A3 protein |
CTD |
PMID:34122009 |
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NCBI chr10:104,549,038...104,559,032
Ensembl chr10:104,549,038...104,559,057
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G |
Eif4e |
eukaryotic translation initiation factor 4E |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in increased expression of EIF4E protein |
CTD |
PMID:34122009 |
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NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
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G |
Eif5b |
eukaryotic translation initiation factor 5B |
increases expression |
ISO |
Clozapine results in increased expression of EIF5B protein |
CTD |
PMID:34122009 |
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NCBI chr 9:40,222,769...40,277,482
Ensembl chr 9:40,222,898...40,277,482
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G |
Eif6 |
eukaryotic translation initiation factor 6 |
decreases expression |
ISO |
Clozapine results in decreased expression of EIF6 protein |
CTD |
PMID:34122009 |
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NCBI chr 3:144,325,038...144,331,396
Ensembl chr 3:144,325,036...144,331,401
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G |
Elk1 |
ETS transcription factor ELK1 |
decreases phosphorylation |
ISO |
Clozapine results in decreased phosphorylation of ELK1 protein |
CTD |
PMID:12871586 |
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NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713
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G |
Eno1 |
enolase 1 |
increases expression |
EXP |
Clozapine results in increased expression of ENO1 mRNA |
CTD |
PMID:15860345 |
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NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336 Ensembl chr 3:160,719,951...160,731,336
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G |
Eno3 |
enolase 3 |
increases expression |
ISO |
Clozapine results in increased expression of ENO3 protein |
CTD |
PMID:34122009 |
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NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921
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G |
Epha7 |
Eph receptor A7 |
increases expression |
ISO |
Clozapine results in increased expression of EPHA7 mRNA |
CTD |
PMID:17266109 |
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NCBI chr 5:42,975,353...43,128,703
Ensembl chr 5:42,975,405...43,127,112
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G |
Ephb3 |
Eph receptor B3 |
increases expression |
ISO |
Clozapine results in increased expression of EPHB3 protein |
CTD |
PMID:34122009 |
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NCBI chr11:79,840,668...79,859,345
Ensembl chr11:79,840,668...79,859,370
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G |
Erap1 |
endoplasmic reticulum aminopeptidase 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of ERAP1 protein |
CTD |
PMID:34122009 |
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NCBI chr 2:3,931,817...3,970,735
Ensembl chr 2:3,931,904...3,972,447
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G |
Erbb2 |
erb-b2 receptor tyrosine kinase 2 |
affects phosphorylation |
EXP |
Clozapine affects the phosphorylation of ERBB2 protein |
CTD |
PMID:26961615 |
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NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
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G |
Erbb4 |
erb-b2 receptor tyrosine kinase 4 |
multiple interactions |
EXP |
Clozapine results in increased expression of and results in increased phosphorylation of ERBB4 protein |
CTD |
PMID:26961615 |
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NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595
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G |
Erh |
ERH, mRNA splicing and mitosis factor |
increases expression |
ISO |
Clozapine results in increased expression of ERH protein |
CTD |
PMID:34122009 |
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NCBI chr 6:100,280,933...100,291,200
Ensembl chr 6:100,280,930...100,291,210
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G |
Erp44 |
endoplasmic reticulum protein 44 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of ERP44 protein |
CTD |
PMID:34122009 |
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NCBI chr 5:62,516,550...62,610,762
Ensembl chr 5:62,516,551...62,610,761
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G |
Ewsr1 |
EWS RNA-binding protein 1 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of EWSR1 protein |
CTD |
PMID:34122009 |
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NCBI chr14:79,965,365...79,994,108
Ensembl chr14:79,965,368...79,994,544
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G |
Exosc4 |
exosome component 4 |
increases expression |
ISO |
Clozapine results in increased expression of EXOSC4 protein |
CTD |
PMID:34122009 |
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NCBI chr 7:108,047,831...108,050,573
Ensembl chr 7:108,047,831...108,050,573
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G |
Ezr |
ezrin |
decreases expression |
ISO |
Clozapine results in decreased expression of EZR protein |
CTD |
PMID:34122009 |
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NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
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G |
Fabp1 |
fatty acid binding protein 1 |
increases expression |
ISO |
Clozapine results in increased expression of FABP1 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
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NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
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G |
Fan1 |
FANCD2 and FANCI associated nuclease 1 |
increases expression |
ISO |
Clozapine results in increased expression of FAN1 protein |
CTD |
PMID:34122009 |
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NCBI chr 1:117,915,323...117,945,044
Ensembl chr 1:117,917,099...117,944,977
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G |
Farsa |
phenylalanyl-tRNA synthetase subunit alpha |
increases expression |
ISO |
Clozapine results in increased expression of FARSA protein |
CTD |
PMID:34122009 |
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NCBI chr19:23,291,409...23,300,985
Ensembl chr19:23,268,869...23,300,980
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G |
Farsb |
phenylalanyl-tRNA synthetase subunit beta |
increases expression |
ISO |
Clozapine results in increased expression of FARSB protein |
CTD |
PMID:34122009 |
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NCBI chr 9:79,887,852...79,947,082
Ensembl chr 9:79,887,842...79,947,045
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G |
Fas |
Fas cell surface death receptor |
multiple interactions |
ISO |
[Clozapine co-treated with Berberine] results in decreased expression of FAS mRNA |
CTD |
PMID:20564506 |
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Faslg |
Fas ligand |
multiple interactions |
ISO |
[Clozapine analog co-treated with Hydrogen Peroxide] results in increased expression of FASLG mRNA; [Clozapine co-treated with Hydrogen Peroxide co-treated with Tretinoin] results in increased expression of FASLG mRNA |
CTD |
PMID:16510162 |
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NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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G |
Fasn |
fatty acid synthase |
increases expression |
ISO |
Clozapine results in increased expression of FASN mRNA |
CTD |
PMID:16027736 PMID:17052361 |
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NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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G |
Fdps |
farnesyl diphosphate synthase |
increases expression |
ISO |
Clozapine results in increased expression of FDPS mRNA |
CTD |
PMID:17052361 |
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NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
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G |
Fen1 |
flap structure-specific endonuclease 1 |
increases expression |
ISO |
Clozapine results in increased expression of FEN1 protein |
CTD |
PMID:34122009 |
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NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003
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G |
Fgf2 |
fibroblast growth factor 2 |
increases expression |
EXP |
Clozapine results in increased expression of FGF2 mRNA |
CTD |
PMID:11264663 |
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NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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G |
Fgl1 |
fibrinogen-like 1 |
increases expression |
ISO |
Clozapine results in increased expression of FGL1 protein |
CTD |
PMID:36482696 |
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NCBI chr16:51,120,652...51,150,907
Ensembl chr16:51,120,694...51,151,093
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G |
Fhod1 |
formin homology 2 domain containing 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of FHOD1 protein |
CTD |
PMID:34122009 |
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NCBI chr19:33,206,492...33,225,448
Ensembl chr19:33,206,492...33,225,356
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G |
Fkbp8 |
FKBP prolyl isomerase 8 |
decreases expression |
ISO |
Clozapine results in decreased expression of FKBP8 protein |
CTD |
PMID:34122009 |
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NCBI chr16:18,895,608...18,902,648
Ensembl chr16:18,893,576...18,902,612
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G |
Flot2 |
flotillin 2 |
increases expression |
ISO |
Clozapine results in increased expression of FLOT2 protein |
CTD |
PMID:34122009 |
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NCBI chr10:62,926,047...62,947,759
Ensembl chr10:62,920,665...62,947,756
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G |
Fmo1 |
flavin containing dimethylaniline monoxygenase 1 |
increases metabolic processing |
ISO |
FMO1 protein results in increased metabolism of Clozapine |
CTD |
PMID:18809730 |
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NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
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G |
Fmo3 |
flavin containing dimethylaniline monoxygenase 3 |
increases metabolic processing |
ISO |
FMO3 protein results in increased metabolism of Clozapine |
CTD |
PMID:18809730 PMID:27320963 |
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NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028
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G |
Fndc4 |
fibronectin type III domain containing 4 |
increases expression |
ISO |
Clozapine results in increased expression of FNDC4 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
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NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases expression decreases expression |
EXP ISO |
Clozapine affects the reaction [Haloperidol results in increased expression of FOS protein]; Cycloserine promotes the reaction [Clozapine results in increased expression of FOS mRNA] Clozapine results in increased expression of FOS protein Clozapine analog results in increased expression of FOS protein; Clozapine results in increased expression of FOS mRNA; Clozapine results in increased expression of FOS protein Clozapine results in decreased expression of FOS protein |
CTD |
PMID:10435392 PMID:11166331 PMID:11440804 PMID:11997696 PMID:12093589 PMID:12243769 PMID:12464447 PMID:17028028 PMID:18208916 PMID:18521575 PMID:19695244 PMID:28272498 More...
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Fosb |
FosB proto-oncogene, AP-1 transcription factor subunit |
increases expression multiple interactions decreases expression |
ISO EXP |
Clozapine results in increased expression of FOSB protein alternative form Clozapine results in increased expression of FOSB mRNA; Clozapine results in increased expression of FOSB protein DRD3 protein affects the reaction [Clozapine results in increased expression of FOSB protein alternative form] Clozapine results in decreased expression of FOSB mRNA |
CTD |
PMID:11259127 PMID:12093589 PMID:12243769 PMID:15579174 PMID:19695244 |
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NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
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G |
Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
increases expression |
EXP |
Clozapine results in increased expression of FOSL1 mRNA |
CTD |
PMID:18208916 |
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NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
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G |
Fosl2 |
FOS like 2, AP-1 transcription factor subunit |
increases expression |
EXP |
Clozapine results in increased expression of FOSL2 mRNA |
CTD |
PMID:12093589 PMID:12243769 |
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NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034
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G |
Foxp2 |
forkhead box P2 |
increases expression |
ISO |
Clozapine results in increased expression of FOXP2 mRNA |
CTD |
PMID:17266109 |
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NCBI chr 4:43,133,827...43,712,442
Ensembl chr 4:43,133,912...43,711,683
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G |
Fstl1 |
follistatin-like 1 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of FSTL1 protein |
CTD |
PMID:34122009 |
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NCBI chr11:62,895,391...62,948,581
Ensembl chr11:62,779,783...62,948,677
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G |
Fubp1 |
far upstream element binding protein 1 |
increases expression |
ISO |
Clozapine results in increased expression of FUBP1 protein |
CTD |
PMID:34122009 |
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NCBI chr 2:241,159,481...241,186,591
Ensembl chr 2:241,159,512...241,186,602
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
decreases expression |
ISO |
Clozapine results in decreased expression of G6PD protein |
CTD |
PMID:34122009 |
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NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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G |
Gabarapl2 |
GABA type A receptor associated protein like 2 |
increases expression |
ISO |
Clozapine results in increased expression of GABARAPL2 protein |
CTD |
PMID:36482696 |
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NCBI chr19:39,910,572...39,921,408
Ensembl chr19:39,910,534...39,924,628
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G |
Gabbr1 |
gamma-aminobutyric acid type B receptor subunit 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of GABBR1 mRNA |
CTD |
PMID:17266109 |
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NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994
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G |
Gabra1 |
gamma-aminobutyric acid type A receptor subunit alpha 1 |
increases expression |
ISO |
Clozapine results in increased expression of GABRA1 mRNA |
CTD |
PMID:17266109 |
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NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
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G |
Gabrb3 |
gamma-aminobutyric acid type A receptor subunit beta 3 |
increases expression |
EXP |
Clozapine results in increased expression of GABRB3 mRNA |
CTD |
PMID:18923069 |
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NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961
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G |
Gad1 |
glutamate decarboxylase 1 |
increases expression decreases methylation multiple interactions |
ISO EXP |
Clozapine results in increased expression of GAD1 mRNA Clozapine results in decreased methylation of GAD1 promoter Clozapine promotes the reaction [KMT2A protein binds to GAD1 promoter]; Valproic Acid promotes the reaction [Clozapine results in decreased methylation of GAD1 promoter] |
CTD |
PMID:12887421 PMID:15061247 PMID:17942719 PMID:18757738 PMID:18923069 |
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NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
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G |
Gad2 |
glutamate decarboxylase 2 |
increases expression |
ISO EXP |
Clozapine results in increased expression of GAD2 mRNA |
CTD |
PMID:17266109 PMID:18923069 |
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NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155
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G |
Gapdh |
glyceraldehyde-3-phosphate dehydrogenase |
increases expression |
EXP ISO |
Clozapine results in increased expression of GAPDH mRNA Clozapine results in increased expression of GAPDH protein |
CTD |
PMID:15860345 PMID:34122009 |
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NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
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G |
Gart |
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase |
increases expression |
ISO |
Clozapine results in increased expression of GART protein |
CTD |
PMID:34122009 |
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NCBI chr11:30,864,896...30,891,125
Ensembl chr11:30,865,889...30,891,125
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G |
Gatm |
glycine amidinotransferase |
increases expression |
ISO |
Clozapine results in increased expression of GATM protein |
CTD |
PMID:34122009 |
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NCBI chr 3:109,658,919...109,675,508
Ensembl chr 3:109,658,951...109,684,129
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G |
Gcc2 |
GRIP and coiled-coil domain containing 2 |
decreases expression |
ISO |
Clozapine results in decreased expression of GCC2 protein |
CTD |
PMID:34122009 |
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NCBI chr20:26,247,394...26,293,613
Ensembl chr20:26,247,404...26,293,613
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G |
Gdf15 |
growth differentiation factor 15 |
increases expression |
ISO |
Clozapine results in increased expression of GDF15 protein |
CTD |
PMID:36482696 |
|
NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
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G |
Gdpd3 |
glycerophosphodiester phosphodiesterase domain containing 3 |
increases expression |
ISO |
Clozapine results in increased expression of GDPD3 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
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NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063
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G |
Gfap |
glial fibrillary acidic protein |
decreases expression increases expression |
EXP |
Clozapine results in decreased expression of GFAP protein Clozapine results in increased expression of GFAP mRNA |
CTD |
PMID:18585900 PMID:19441803 |
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NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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G |
Ghitm |
growth hormone inducible transmembrane protein |
increases expression |
ISO |
Clozapine results in increased expression of GHITM protein |
CTD |
PMID:34122009 |
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NCBI chr16:12,885,551...12,897,887
Ensembl chr16:12,885,553...12,897,879
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G |
Gimap5 |
GTPase, IMAP family member 5 |
decreases expression |
EXP |
Clozapine results in decreased expression of GIMAP5 mRNA |
CTD |
PMID:16715494 |
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NCBI chr 4:77,693,417...77,701,025
Ensembl chr 4:77,687,564...77,703,086
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G |
Gip |
gastric inhibitory polypeptide |
increases expression |
EXP |
Clozapine results in increased expression of GIP mRNA; Clozapine results in increased expression of GIP protein |
CTD |
PMID:16402076 |
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NCBI chr10:80,968,360...80,976,506
Ensembl chr10:80,968,352...80,976,503
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G |
Gja1 |
gap junction protein, alpha 1 |
increases expression |
EXP |
Clozapine results in increased expression of GJA1 protein |
CTD |
PMID:18585900 |
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NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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G |
Glp1r |
glucagon-like peptide 1 receptor |
multiple interactions decreases expression |
EXP |
PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of GLP1R protein] |
CTD |
PMID:37087062 |
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NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241
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G |
Glrx3 |
glutaredoxin 3 |
increases expression |
ISO |
Clozapine results in increased expression of GLRX3 protein |
CTD |
PMID:34122009 |
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NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010
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G |
Glul |
glutamate-ammonia ligase |
decreases expression |
ISO |
Clozapine results in decreased expression of GLUL protein |
CTD |
PMID:36482696 |
|
NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108
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G |
Gna12 |
G protein subunit alpha 12 |
decreases expression increases expression |
EXP ISO |
Clozapine results in decreased expression of GNA12 mRNA Clozapine results in increased expression of GNA12 protein |
CTD |
PMID:15860345 PMID:34122009 |
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NCBI chr12:13,805,580...13,886,255
Ensembl chr12:13,805,698...13,886,255
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G |
Gnai1 |
G protein subunit alpha i1 |
decreases expression |
EXP |
Clozapine results in decreased expression of GNAI1 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417
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G |
Gnai2 |
G protein subunit alpha i2 |
decreases expression |
EXP |
Clozapine results in decreased expression of GNAI2 mRNA |
CTD |
PMID:15860345 |
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NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
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G |
Gnai3 |
G protein subunit alpha i3 |
decreases expression |
EXP |
Clozapine results in decreased expression of GNAI3 mRNA |
CTD |
PMID:15860345 |
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NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742
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G |
Gnas |
GNAS complex locus |
decreases expression multiple interactions increases expression |
EXP ISO |
Clozapine results in decreased expression of GNAS mRNA [Cuprizone co-treated with Clozapine] results in decreased expression of GNAS protein Clozapine results in increased expression of GNAS protein |
CTD |
PMID:15860345 PMID:34122009 |
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NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262 Ensembl chr 3:163,071,417...163,127,262
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G |
Gnb3 |
G protein subunit beta 3 |
decreases response to substance increases expression affects response to substance increases response to substance |
ISO EXP |
GNB3 gene polymorphism results in decreased susceptibility to Clozapine Clozapine results in increased expression of GNB3 protein GNB3 protein affects the susceptibility to Clozapine GNB3 gene polymorphism results in increased susceptibility to Clozapine |
CTD |
PMID:16139171 PMID:16141801 PMID:18855531 |
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NCBI chr 4:157,639,468...157,645,171
Ensembl chr 4:157,639,469...157,645,173
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G |
Golga3 |
golgin A3 |
increases expression |
ISO |
Clozapine results in increased expression of GOLGA3 protein |
CTD |
PMID:34122009 |
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NCBI chr12:46,452,409...46,500,509
Ensembl chr12:46,454,870...46,500,509 Ensembl chr 4:46,454,870...46,500,509
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G |
Golgb1 |
golgin B1 |
increases expression |
ISO |
Clozapine results in increased expression of GOLGB1 protein |
CTD |
PMID:34122009 |
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NCBI chr11:63,843,179...63,900,665
Ensembl chr11:63,843,986...63,900,770
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G |
Got2 |
glutamic-oxaloacetic transaminase 2 |
increases expression multiple interactions |
EXP ISO |
Clozapine results in increased expression of GOT2 mRNA [Cuprizone co-treated with Clozapine] results in increased expression of GOT2 protein |
CTD |
PMID:15860345 PMID:34122009 |
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NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
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G |
Gpd2 |
glycerol-3-phosphate dehydrogenase 2 |
decreases expression |
ISO |
Clozapine results in decreased expression of GPD2 protein |
CTD |
PMID:34122009 |
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NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901
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G |
Gpi |
glucose-6-phosphate isomerase |
increases expression |
ISO |
Clozapine results in increased expression of GPI protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
[Chloroquine co-treated with Clozapine] results in increased secretion of GPT protein |
CTD |
PMID:36482696 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gpx1 |
glutathione peroxidase 1 |
increases expression |
ISO |
Clozapine results in increased expression of GPX1 mRNA |
CTD |
PMID:14647396 |
|
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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G |
Grik2 |
glutamate ionotropic receptor kainate type subunit 2 |
increases expression |
EXP |
Clozapine results in increased expression of GRIK2 mRNA |
CTD |
PMID:18923069 |
|
NCBI chr20:52,135,325...52,833,061
Ensembl chr20:52,133,851...52,838,375
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G |
Grik5 |
glutamate ionotropic receptor kainate type subunit 5 |
affects expression decreases expression |
ISO EXP |
Clozapine affects the expression of GRIK5 mRNA Clozapine results in decreased expression of GRIK5 mRNA |
CTD |
PMID:14647396 PMID:18923069 |
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NCBI chr 1:80,605,878...80,667,896
Ensembl chr 1:80,605,892...80,667,125
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G |
Grin1 |
glutamate ionotropic receptor NMDA type subunit 1 |
decreases expression increases expression |
ISO EXP |
Clozapine results in decreased expression of GRIN1 mRNA Clozapine results in increased expression of GRIN1 mRNA |
CTD |
PMID:12020038 PMID:12608697 PMID:17266109 PMID:18923069 |
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NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
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G |
Grin2a |
glutamate ionotropic receptor NMDA type subunit 2A |
decreases expression |
EXP |
Clozapine results in decreased expression of GRIN2A mRNA |
CTD |
PMID:12608697 PMID:18923069 |
|
NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637
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G |
Grin2b |
glutamate ionotropic receptor NMDA type subunit 2B |
decreases expression |
EXP |
Clozapine results in decreased expression of GRIN2B mRNA |
CTD |
PMID:18923069 |
|
NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
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G |
Grin2c |
glutamate ionotropic receptor NMDA type subunit 2C |
decreases expression |
EXP |
Clozapine results in decreased expression of GRIN2C mRNA |
CTD |
PMID:18923069 |
|
NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427
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G |
Grk6 |
G protein-coupled receptor kinase 6 |
decreases expression |
EXP |
Clozapine results in decreased expression of GRK6 mRNA |
CTD |
PMID:16715494 |
|
NCBI chr17:9,177,018...9,192,813
Ensembl chr17:9,177,019...9,192,644
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G |
Gsk3a |
glycogen synthase kinase 3 alpha |
increases expression multiple interactions |
EXP |
Clozapine results in increased expression of GSK3A protein DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3A protein] |
CTD |
PMID:16144542 |
|
NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
increases phosphorylation increases expression multiple interactions |
ISO EXP |
Clozapine results in increased phosphorylation of GSK3B protein Clozapine results in increased expression of GSK3B protein DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein] |
CTD |
PMID:16144542 PMID:19359144 PMID:19440698 |
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Gsta1 |
glutathione S-transferase alpha 1 |
decreases activity increases glutathionylation |
ISO |
GSTA1 protein results in decreased activity of Clozapine GSTA1 protein results in increased glutathionylation of Clozapine |
CTD |
PMID:20849150 |
|
NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
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G |
Gstm1 |
glutathione S-transferase mu 1 |
decreases activity increases expression increases glutathionylation |
ISO EXP |
GSTM1 protein results in decreased activity of Clozapine Clozapine results in increased expression of GSTM1 mRNA GSTM1 protein results in increased glutathionylation of Clozapine |
CTD |
PMID:15860345 PMID:20849150 |
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NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
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G |
Gstm2 |
glutathione S-transferase mu 2 |
decreases expression |
EXP |
Clozapine results in decreased expression of GSTM2 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
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G |
Gstp1 |
glutathione S-transferase pi 1 |
decreases activity affects metabolic processing increases glutathionylation affects binding |
ISO |
Clozapine metabolite results in decreased activity of GSTP1 protein; GSTP1 protein results in decreased activity of Clozapine GSTP1 protein affects the metabolism of Clozapine metabolite GSTP1 protein results in increased glutathionylation of Clozapine Clozapine metabolite binds to GSTP1 protein |
CTD |
PMID:20849150 PMID:21639118 PMID:24185126 |
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
H1f2 |
H1.2 linker histone, cluster member |
increases expression |
ISO |
Clozapine results in increased expression of H1-2 protein |
CTD |
PMID:34122009 |
|
NCBI chr17:41,391,106...41,392,597
Ensembl chr17:41,388,477...41,392,635
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G |
H2ac18 |
H2A clustered histone 18 |
increases expression |
ISO |
Clozapine results in increased expression of H2AC18 mRNA |
CTD |
PMID:14647396 |
|
NCBI chr 2:183,808,398...183,808,992
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G |
H2ac20 |
H2A clustered histone 20 |
increases expression |
ISO |
Clozapine results in increased expression of H2AC20 protein |
CTD |
PMID:34122009 |
|
NCBI chr 2:183,779,879...183,780,357
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G |
H2aj |
H2A.J histone |
increases expression |
ISO |
Clozapine results in increased expression of H2AJ protein |
CTD |
PMID:34122009 |
|
NCBI chr 4:169,675,718...169,676,202
Ensembl chr 4:169,675,752...169,677,006
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G |
Haao |
3-hydroxyanthranilate 3,4-dioxygenase |
decreases expression |
ISO |
Clozapine results in decreased expression of HAAO protein |
CTD |
PMID:36482696 |
|
NCBI chr 6:10,845,235...10,864,863
Ensembl chr 6:10,845,771...10,864,877
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G |
Hacd3 |
3-hydroxyacyl-CoA dehydratase 3 |
increases expression |
ISO |
Clozapine results in increased expression of HACD3 protein |
CTD |
PMID:34122009 |
|
NCBI chr 8:65,501,240...65,538,507
Ensembl chr 8:65,501,240...65,538,507
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G |
Hadhb |
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta |
increases expression |
ISO |
Clozapine results in increased expression of HADHB protein |
CTD |
PMID:34122009 |
|
NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869
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G |
Hars1 |
histidyl-tRNA synthetase 1 |
increases expression |
ISO |
Clozapine results in increased expression of HARS1 protein |
CTD |
PMID:34122009 |
|
NCBI chr18:28,381,649...28,398,699
Ensembl chr18:28,381,655...28,398,740
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G |
Hat1 |
histone acetyltransferase 1 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of HAT1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:56,217,344...56,265,021
Ensembl chr 3:56,217,342...56,275,517
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G |
Hcls1 |
hematopoietic cell specific Lyn substrate 1 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of HCLS1 protein |
CTD |
PMID:34122009 |
|
NCBI chr11:63,817,482...63,840,943
Ensembl chr11:63,817,476...63,841,014
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G |
Hdgfl2 |
HDGF like 2 |
increases expression |
ISO |
Clozapine results in increased expression of HDGFRP2 protein |
CTD |
PMID:34122009 |
|
NCBI chr 9:909,581...929,195
Ensembl chr 9:909,614...929,186
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G |
Higd1a |
HIG1 hypoxia inducible domain family, member 1A |
increases expression |
ISO |
Clozapine results in increased expression of HIGD1A mRNA |
CTD |
PMID:14647396 |
|
NCBI chr 8:121,514,152...121,523,382
Ensembl chr 8:121,514,156...121,523,443
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G |
Hmgb2 |
high mobility group box 2 |
increases expression |
ISO |
Clozapine results in increased expression of HMGB2 protein |
CTD |
PMID:34122009 |
|
NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140 Ensembl chr 1:32,710,658...32,713,140
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
multiple interactions increases expression increases activity |
ISO |
[Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Cholesterol; [Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Triglycerides Clozapine results in increased expression of HMGCR mRNA |
CTD |
PMID:16027736 PMID:17052361 |
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NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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G |
Hmgcs1 |
3-hydroxy-3-methylglutaryl-CoA synthase 1 |
increases expression |
ISO |
Clozapine results in increased expression of HMGCS1 mRNA |
CTD |
PMID:16027736 PMID:17052361 |
|
NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
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G |
Hmox1 |
heme oxygenase 1 |
increases expression |
ISO |
Clozapine results in increased expression of HMOX1 mRNA |
CTD |
PMID:18227147 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hnrnpd |
heterogeneous nuclear ribonucleoprotein D |
decreases expression |
ISO |
Clozapine results in decreased expression of HNRNPD protein |
CTD |
PMID:34122009 |
|
NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786
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G |
Hnrnph2 |
heterogeneous nuclear ribonucleoprotein H2 |
decreases expression |
ISO |
Clozapine results in decreased expression of HNRNPH2 protein |
CTD |
PMID:36482696 |
|
NCBI chr X:97,780,890...97,786,846
Ensembl chr X:97,780,785...97,787,041
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G |
Homer1 |
homer scaffold protein 1 |
increases expression multiple interactions |
EXP |
Clozapine results in increased expression of HOMER1 mRNA Cycloserine inhibits the reaction [Clozapine results in increased expression of HOMER1 mRNA] |
CTD |
PMID:12464447 PMID:15860345 |
|
NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
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G |
Hpcal1 |
hippocalcin-like 1 |
decreases expression |
EXP |
Clozapine results in decreased expression of HPCAL1 mRNA |
CTD |
PMID:12437575 |
|
NCBI chr 6:40,478,206...40,584,721
Ensembl chr 6:40,478,208...40,584,687
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G |
Hpcal4 |
hippocalcin-like 4 |
affects expression |
EXP |
Clozapine affects the expression of HPCAL4 mRNA |
CTD |
PMID:12437575 |
|
NCBI chr 5:135,454,477...135,466,417
Ensembl chr 5:135,454,540...135,466,416
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G |
Hpn |
hepsin |
increases expression |
ISO |
Clozapine results in increased expression of HPN mRNA |
CTD |
PMID:15342952 |
|
NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811
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G |
Hrh1 |
histamine receptor H 1 |
affects binding |
ISO |
Clozapine binds to HRH1 protein |
CTD |
PMID:16983399 |
|
NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455
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G |
Hrh3 |
histamine receptor H3 |
multiple interactions |
EXP |
Clozapine binds to Hrh3 protein; Clozapine inhibits the reaction [N-methylhistamine binds to Hrh3 protein] |
RGD |
PMID:10869375 |
RGD:632981 |
NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642
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G |
Hsd17b10 |
hydroxysteroid (17-beta) dehydrogenase 10 |
decreases expression |
ISO |
Clozapine results in decreased expression of HSD17B10 protein |
CTD |
PMID:34122009 |
|
NCBI chr X:21,089,142...21,091,603
Ensembl chr X:21,089,122...21,109,488
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G |
Hsd17b12 |
hydroxysteroid (17-beta) dehydrogenase 12 |
increases expression |
ISO |
Clozapine results in increased expression of HSD17B12 protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:79,990,048...80,113,556
Ensembl chr 3:79,990,056...80,113,617
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G |
Hspa9 |
heat shock protein family A (Hsp70) member 9 |
decreases expression |
ISO |
Clozapine results in decreased expression of HSPA9 protein |
CTD |
PMID:34122009 |
|
NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
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G |
Htr1a |
5-hydroxytryptamine receptor 1A |
multiple interactions affects binding |
ISO EXP |
Clozapine binds to and affects the activity of HTR1A protein Clozapine binds to HTR1A protein |
CTD |
PMID:9723970 PMID:15482641 |
|
NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442
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G |
Htr1d |
5-hydroxytryptamine receptor 1D |
decreases expression |
EXP |
Clozapine results in decreased expression of HTR1D mRNA |
CTD |
PMID:16715494 |
|
NCBI chr 5:148,656,252...148,676,532
Ensembl chr 5:148,674,495...148,675,619
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G |
Htr2a |
5-hydroxytryptamine receptor 2A |
increases response to substance affects binding multiple interactions decreases expression decreases activity affects response to substance increases expression |
ISO EXP |
HTR2A gene SNP results in increased susceptibility to Clozapine Clozapine analog binds to HTR2A protein; Clozapine binds to HTR2A protein Clozapine binds to and results in decreased activity of HTR2A protein; Clozapine inhibits the reaction [Ketanserin binds to HTR2A protein] Clozapine results in decreased expression of HTR2A mRNA; Clozapine results in decreased expression of HTR2A protein Clozapine results in decreased activity of HTR2A protein [[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]; Clozapine binds to and results in decreased activity of HTR2A protein; Clozapine promotes the reaction [Phencyclidine results in decreased activity of HTR2A protein] HTR2A protein affects the susceptibility to Clozapine Clozapine results in increased expression of HTR2A mRNA |
CTD |
PMID:7520908 PMID:9723970 PMID:11997696 PMID:14751426 PMID:15380371 PMID:15542763 PMID:16314884 PMID:16983399 PMID:17868938 PMID:18976543 PMID:20521326 More...
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NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
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G |
Htr2c |
5-hydroxytryptamine receptor 2C |
affects binding decreases expression affects response to substance |
ISO EXP |
Clozapine binds to HTR2C protein Clozapine results in decreased expression of HTR2C mRNA HTR2C gene polymorphism affects the susceptibility to Clozapine; HTR2C gene SNP affects the susceptibility to Clozapine; HTR2C promoter SNP affects the susceptibility to Clozapine; HTR2C protein affects the susceptibility to Clozapine |
CTD |
PMID:9723970 PMID:12668355 PMID:15635667 PMID:16983399 PMID:17868938 PMID:19142101 PMID:19142110 More...
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NCBI chr X:110,640,777...110,870,288
Ensembl chr X:110,641,153...110,870,287
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G |
Htr3a |
5-hydroxytryptamine receptor 3A |
multiple interactions affects response to substance |
ISO |
Clozapine binds to and results in decreased activity of HTR3A protein HTR3A protein affects the susceptibility to Clozapine |
CTD |
PMID:19696922 PMID:20168265 |
|
NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389
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G |
Htr6 |
5-hydroxytryptamine receptor 6 |
multiple interactions affects binding |
ISO |
Clozapine binds to and results in decreased activity of HTR6 protein [Cuprizone co-treated with Clozapine] results in increased expression of HTR6 protein Clozapine binds to HTR6 protein |
CTD |
PMID:11406289 PMID:16983399 PMID:34122009 |
|
NCBI chr 5:151,295,269...151,312,853
Ensembl chr 5:151,296,662...151,311,912
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G |
Htr7 |
5-hydroxytryptamine receptor 7 |
affects binding multiple interactions |
ISO |
Clozapine binds to HTR7 protein [Clozapine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]; Clozapine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein] |
CTD |
PMID:14578406 PMID:20827463 |
|
NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626
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G |
Id2 |
inhibitor of DNA binding 2 |
increases expression |
EXP |
Clozapine results in increased expression of ID2 mRNA |
CTD |
PMID:12437575 |
|
NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
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G |
Idh2 |
isocitrate dehydrogenase (NADP(+)) 2 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of IDH2 protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
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G |
Idi1 |
isopentenyl-diphosphate delta isomerase 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of IDI1 protein |
CTD |
PMID:34122009 |
|
NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
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G |
Ifng |
interferon gamma |
affects expression decreases expression |
ISO |
Clozapine affects the expression of IFNG protein Clozapine results in decreased expression of IFNG mRNA |
CTD |
PMID:17346280 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Ifngr1 |
interferon gamma receptor 1 |
increases expression |
ISO |
Clozapine results in increased expression of IFNGR1 protein |
CTD |
PMID:36482696 |
|
NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785
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G |
Igf1 |
insulin-like growth factor 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of IGF1 protein |
CTD |
PMID:11769361 |
|
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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G |
Igfbp1 |
insulin-like growth factor binding protein 1 |
increases expression |
ISO |
Clozapine results in increased expression of IGFBP1 protein |
CTD |
PMID:36482696 |
|
NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
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G |
Il10 |
interleukin 10 |
decreases expression |
EXP |
Clozapine results in decreased expression of IL10 protein |
CTD |
PMID:24709159 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il1b |
interleukin 1 beta |
increases secretion multiple interactions |
EXP |
Clozapine results in increased secretion of IL1B protein belnacasan inhibits the reaction [Clozapine results in increased secretion of IL1B protein] |
CTD |
PMID:34935985 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il2ra |
interleukin 2 receptor subunit alpha |
increases secretion |
ISO |
Clozapine results in increased secretion of IL2RA protein |
CTD |
PMID:8067274 |
|
NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
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G |
Il5 |
interleukin 5 |
affects expression |
ISO |
Clozapine affects the expression of IL5 protein |
CTD |
PMID:17346280 |
|
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
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G |
Ilkap |
ILK associated serine/threonine phosphatase |
decreases expression |
EXP |
Clozapine results in decreased expression of ILKAP mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 9:91,966,440...91,988,791
Ensembl chr 9:91,966,441...91,988,892
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G |
Inha |
inhibin subunit alpha |
decreases expression |
EXP |
Clozapine results in decreased expression of INHA mRNA |
CTD |
PMID:16715494 |
|
NCBI chr 9:76,994,465...76,997,366
Ensembl chr 9:76,993,589...76,997,248
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G |
Inhbe |
inhibin subunit beta E |
increases expression |
ISO |
Clozapine results in increased expression of INHBE mRNA |
CTD |
PMID:15342952 PMID:17175557 |
|
NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172
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G |
Ins2 |
insulin 2 |
affects secretion increases expression |
ISO |
Clozapine affects the secretion of INS protein Clozapine results in increased expression of INS protein |
CTD |
PMID:11769361 PMID:16601995 |
|
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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G |
Itga6 |
integrin subunit alpha 6 |
increases expression |
ISO |
Clozapine results in increased expression of ITGA6 protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428
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G |
Jak1 |
Janus kinase 1 |
increases expression |
ISO |
Clozapine results in increased expression of JAK1 protein |
CTD |
PMID:36482696 |
|
NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
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G |
Jak2 |
Janus kinase 2 |
multiple interactions |
EXP |
[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein] |
CTD |
PMID:18976543 |
|
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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|
G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
decreases expression increases expression |
EXP |
Clozapine results in decreased expression of JUN mRNA Clozapine results in increased expression of JUN mRNA |
CTD |
PMID:12093589 PMID:15860345 PMID:18208916 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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|
G |
Junb |
JunB proto-oncogene, AP-1 transcription factor subunit |
increases expression |
EXP |
Clozapine results in increased expression of JUNB mRNA |
CTD |
PMID:12093589 PMID:19695244 |
|
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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|
G |
Jund |
JunD proto-oncogene, AP-1 transcription factor subunit |
decreases expression |
EXP |
Clozapine results in decreased expression of JUND mRNA |
CTD |
PMID:12093589 |
|
NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
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G |
Kcna1 |
potassium voltage-gated channel subfamily A member 1 |
increases expression |
ISO |
Clozapine results in increased expression of KCNA1 mRNA |
CTD |
PMID:18797397 |
|
NCBI chr 4:159,464,223...159,472,905
Ensembl chr 4:159,464,188...159,472,682
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
multiple interactions |
ISO |
Clozapine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] |
CTD |
PMID:21158687 |
|
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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|
G |
Kcnip3 |
potassium voltage-gated channel interacting protein 3 |
decreases expression increases expression |
ISO |
Clozapine results in decreased expression of KCNIP3 mRNA Clozapine results in increased expression of KCNIP3 mRNA |
CTD |
PMID:17266109 PMID:18797397 |
|
NCBI chr 3:114,677,027...114,742,923
Ensembl chr 3:114,677,030...114,743,556
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G |
Kcnk2 |
potassium two pore domain channel subfamily K member 2 |
decreases expression |
ISO |
Clozapine results in decreased expression of KCNK2 mRNA |
CTD |
PMID:15542763 |
|
NCBI chr13:100,766,101...100,963,435
Ensembl chr13:100,766,113...100,963,435
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G |
Kctd12 |
potassium channel tetramerization domain containing 12 |
decreases expression |
ISO |
Clozapine results in decreased expression of KCTD12 protein |
CTD |
PMID:34122009 |
|
NCBI chr15:79,800,078...79,806,017
Ensembl chr15:79,801,191...79,806,282
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G |
Kdr |
kinase insert domain receptor |
increases expression |
ISO |
Clozapine results in increased expression of KDR protein |
CTD |
PMID:34122009 |
|
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
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G |
Khdrbs1 |
KH RNA binding domain containing, signal transduction associated 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of KHDRBS1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 5:142,051,844...142,089,175
Ensembl chr 5:142,063,570...142,089,180
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G |
Kif13b |
kinesin family member 13B |
increases expression |
ISO |
Clozapine results in increased expression of KIF13B protein |
CTD |
PMID:34122009 |
|
NCBI chr15:38,908,257...39,066,021
Ensembl chr15:38,924,624...39,084,879
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G |
Kif5c |
kinesin family member 5C |
decreases expression |
ISO |
Clozapine results in decreased expression of KIF5C protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:34,032,082...34,185,597
Ensembl chr 3:34,032,105...34,182,413
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G |
Kiz |
kizuna centrosomal protein |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of KIZ protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:134,277,631...134,385,260
Ensembl chr 3:134,277,687...134,385,190
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G |
Klhdc2 |
kelch domain containing 2 |
decreases expression |
ISO |
Clozapine results in decreased expression of KLHDC2 protein |
CTD |
PMID:34122009 |
|
NCBI chr 6:87,777,183...87,791,609
Ensembl chr 6:87,777,183...87,804,187
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G |
Kmt2a |
lysine methyltransferase 2A |
increases expression decreases expression multiple interactions |
ISO |
Clozapine results in increased expression of KMT2A mRNA Clozapine results in decreased expression of KMT2A mRNA Clozapine promotes the reaction [KMT2A protein binds to GAD1 promoter] |
CTD |
PMID:14647396 PMID:17942719 |
|
NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181
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G |
Kpna4 |
karyopherin subunit alpha 4 |
multiple interactions increases expression |
ISO |
[Cuprizone co-treated with Clozapine] results in increased expression of KPNA4 protein Clozapine results in increased expression of KPNA4 protein |
CTD |
PMID:34122009 |
|
NCBI chr 2:153,319,380...153,381,085
Ensembl chr 2:153,324,273...153,381,081
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G |
Kremen1 |
kringle containing transmembrane protein 1 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of KREMEN1 protein |
CTD |
PMID:34122009 |
|
NCBI chr14:80,081,870...80,147,489
Ensembl chr14:80,084,403...80,147,516
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G |
Lactb2 |
lactamase, beta 2 |
increases expression |
ISO |
Clozapine results in increased expression of LACTB2 protein |
CTD |
PMID:34122009 |
|
NCBI chr 5:5,569,080...5,591,843
Ensembl chr 5:5,569,067...5,596,429
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G |
Lamp1 |
lysosomal-associated membrane protein 1 |
increases expression |
ISO |
Clozapine results in increased expression of LAMP1 protein |
CTD |
PMID:34122009 |
|
NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883
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G |
Lamtor3 |
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 |
increases expression |
ISO |
Clozapine results in increased expression of LAMTOR3 mRNA |
CTD |
PMID:14647396 |
|
NCBI chr 2:226,411,389...226,423,612
Ensembl chr 2:226,411,400...226,423,607
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G |
Larp7 |
La ribonucleoprotein 7, transcriptional regulator |
increases expression |
ISO |
Clozapine results in increased expression of LARP7 protein |
CTD |
PMID:34122009 |
|
NCBI chr 2:215,997,641...216,012,833
Ensembl chr 2:215,997,649...216,012,865
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G |
Lcn1 |
lipocalin 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of LCN1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:9,532,860...9,537,859
Ensembl chr 3:9,532,915...9,536,577
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G |
Ldhb |
lactate dehydrogenase B |
increases expression |
EXP |
Clozapine results in increased expression of LDHB mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403
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G |
Ldlr |
low density lipoprotein receptor |
increases expression multiple interactions |
ISO |
Clozapine results in increased expression of LDLR mRNA Berberine inhibits the reaction [Clozapine results in increased expression of LDLR mRNA] |
CTD |
PMID:17052361 PMID:20564506 |
|
NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
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G |
Leap2 |
liver enriched antimicrobial peptide 2 |
increases expression |
ISO |
Clozapine results in increased expression of LEAP2 mRNA |
CTD |
PMID:17346280 |
|
NCBI chr10:37,580,172...37,581,244
Ensembl chr10:37,577,855...37,581,244
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G |
Lemd2 |
LEM domain nuclear envelope protein 2 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in increased expression of LEMD2 protein |
CTD |
PMID:34122009 |
|
NCBI chr20:5,282,397...5,296,621
Ensembl chr20:5,282,397...5,296,626
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G |
Lep |
leptin |
affects response to substance increases expression |
ISO EXP |
LEP protein affects the susceptibility to Clozapine Clozapine results in increased expression of LEP protein |
CTD |
PMID:16402076 PMID:17502770 |
|
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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G |
Lgals8 |
galectin 8 |
increases expression |
ISO |
Clozapine results in increased expression of LGALS8 protein |
CTD |
PMID:36482696 |
|
NCBI chr17:58,024,652...58,052,764
Ensembl chr17:58,028,105...58,052,764
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G |
Lipa |
lipase A, lysosomal acid type |
increases expression |
ISO |
Clozapine results in increased expression of LIPA protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:232,024,351...232,057,735
Ensembl chr 1:232,024,356...232,057,633
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G |
Lmod2 |
leiomodin 2 |
increases expression |
ISO |
Clozapine results in increased expression of LMOD2 protein |
CTD |
PMID:34122009 |
|
NCBI chr 4:53,067,428...53,075,124
Ensembl chr 4:53,067,428...53,075,120
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G |
Lpl |
lipoprotein lipase |
decreases expression increases expression |
ISO |
Clozapine results in decreased expression of LPL mRNA; Clozapine results in decreased expression of LPL protein Clozapine results in increased expression of LPL mRNA |
CTD |
PMID:17266109 PMID:19682446 |
|
NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
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G |
Lrp10 |
LDL receptor related protein 10 |
increases expression |
ISO |
Clozapine results in increased expression of LRP10 protein |
CTD |
PMID:36482696 |
|
NCBI chr15:27,921,335...27,927,507
Ensembl chr15:27,920,259...27,927,505
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G |
Lrpprc |
leucine-rich pentatricopeptide repeat containing |
increases expression |
ISO |
Clozapine results in increased expression of LRPPRC protein |
CTD |
PMID:34122009 |
|
NCBI chr 6:9,859,816...9,942,294
Ensembl chr 6:9,859,867...9,942,293
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G |
Lrrk2 |
leucine-rich repeat kinase 2 |
increases expression |
ISO |
Clozapine results in increased expression of LRRK2 protein |
CTD |
PMID:34122009 |
|
NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703
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G |
Lss |
lanosterol synthase |
increases expression multiple interactions |
ISO |
Clozapine results in increased expression of LSS mRNA [Cuprizone co-treated with Clozapine] results in decreased expression of LSS protein |
CTD |
PMID:15342952 PMID:17175557 PMID:34122009 |
|
NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
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G |
Lta4h |
leukotriene A4 hydrolase |
decreases expression |
ISO |
Clozapine results in decreased expression of LTA4H protein |
CTD |
PMID:34122009 |
|
NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600
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G |
Magt1 |
magnesium transporter 1 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of MAGT1 protein |
CTD |
PMID:34122009 |
|
NCBI chr X:71,038,489...71,079,704
Ensembl chr X:71,038,489...71,079,699
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G |
Mal |
mal, T-cell differentiation protein |
decreases expression |
ISO |
Clozapine results in decreased expression of MAL mRNA |
CTD |
PMID:17266109 PMID:18797397 |
|
NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136
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G |
Maob |
monoamine oxidase B |
increases expression |
ISO |
Clozapine results in increased expression of MAOB mRNA |
CTD |
PMID:17266109 |
|
NCBI chr X:5,907,327...6,010,996
Ensembl chr X:5,907,266...6,011,003
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G |
Map1a |
microtubule-associated protein 1A |
increases expression decreases expression |
EXP ISO |
Clozapine results in increased expression of MAP1A mRNA Clozapine results in decreased expression of MAP1A protein |
CTD |
PMID:15860345 PMID:34122009 |
|
NCBI chr 3:108,263,217...108,283,936
Ensembl chr 3:108,263,151...108,282,899
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G |
Map1b |
microtubule-associated protein 1B |
decreases expression |
ISO |
Clozapine results in decreased expression of MAP1B protein |
CTD |
PMID:34122009 |
|
NCBI chr 2:30,817,261...30,910,458
Ensembl chr 2:30,817,261...30,910,317
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
increases lipidation multiple interactions |
ISO |
Clozapine results in increased lipidation of MAP1LC3B protein [Chloroquine co-treated with Clozapine] results in increased lipidation of MAP1LC3B protein |
CTD |
PMID:36482696 |
|
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 Ensembl chr16:49,665,791...49,677,690
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G |
Map1s |
microtubule-associated protein 1S |
increases expression |
ISO |
Clozapine results in increased expression of MAP1S protein |
CTD |
PMID:34122009 |
|
NCBI chr16:18,516,759...18,527,777
Ensembl chr16:18,517,574...18,527,988
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G |
Map2k1 |
mitogen activated protein kinase kinase 1 |
decreases expression |
EXP |
Clozapine results in decreased expression of MAP2K1 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
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G |
Map2k2 |
mitogen activated protein kinase kinase 2 |
increases expression decreases expression |
ISO EXP |
Clozapine results in increased expression of MAP2K2 mRNA Clozapine results in decreased expression of MAP2K2 mRNA |
CTD |
PMID:14647396 PMID:15860345 |
|
NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
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G |
Map2k5 |
mitogen activated protein kinase kinase 5 |
decreases expression |
EXP |
Clozapine results in decreased expression of MAP2K5 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983
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G |
Map3k1 |
mitogen-activated protein kinase kinase kinase 1 |
increases expression |
EXP |
Clozapine results in increased expression of MAP3K1 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463
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G |
Map3k12 |
mitogen activated protein kinase kinase kinase 12 |
increases expression |
EXP |
Clozapine results in increased expression of MAP3K12 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 7:133,630,267...133,648,464
Ensembl chr 7:133,630,835...133,640,789
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions decreases expression decreases phosphorylation |
ISO EXP |
Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK1 protein] Clozapine results in decreased expression of MAPK1 mRNA Clozapine results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:12871586 PMID:15860345 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk14 |
mitogen activated protein kinase 14 |
affects expression |
EXP |
Clozapine affects the expression of MAPK14 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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G |
Mapk3 |
mitogen activated protein kinase 3 |
decreases phosphorylation multiple interactions |
ISO |
Clozapine results in decreased phosphorylation of MAPK3 protein Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:12871586 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk6 |
mitogen-activated protein kinase 6 |
affects expression |
EXP |
Clozapine affects the expression of MAPK6 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:76,146,690...76,169,720
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G |
Mapk8ip1 |
mitogen-activated protein kinase 8 interacting protein 1 |
increases expression |
ISO |
Clozapine results in increased expression of MAPK8IP1 mRNA |
CTD |
PMID:17266109 |
|
NCBI chr 3:78,355,051...78,372,946
Ensembl chr 3:78,355,048...78,372,884
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|
G |
Mapk9 |
mitogen-activated protein kinase 9 |
affects expression |
EXP |
Clozapine affects the expression of MAPK9 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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|
G |
Mapre1 |
microtubule-associated protein, RP/EB family, member 1 |
decreases expression multiple interactions |
ISO |
Clozapine results in decreased expression of MAPRE1 protein [Cuprizone co-treated with Clozapine] results in decreased expression of MAPRE1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:142,218,846...142,246,990
Ensembl chr 3:142,212,955...142,246,983
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|
G |
Mas1 |
MAS1 proto-oncogene, G protein-coupled receptor |
decreases expression |
EXP |
Clozapine results in decreased expression of MAS1 mRNA |
CTD |
PMID:16715494 |
|
NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709
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G |
Mat2a |
methionine adenosyltransferase 2A |
decreases expression |
ISO |
Clozapine results in decreased expression of MAT2A protein |
CTD |
PMID:34122009 |
|
NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493
|
|
G |
Mat2b |
methionine adenosyltransferase 2 non-catalytic beta subunit |
decreases expression |
ISO |
Clozapine results in decreased expression of MAT2B protein |
CTD |
PMID:34122009 |
|
NCBI chr10:25,106,928...25,122,982
Ensembl chr10:25,106,930...25,122,777
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|
G |
Mbp |
myelin basic protein |
increases expression |
ISO |
Clozapine results in increased expression of MBP mRNA |
CTD |
PMID:17266109 PMID:17346280 |
|
NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
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|
G |
Mc1r |
melanocortin 1 receptor |
increases expression |
ISO |
Clozapine results in increased expression of MC1R mRNA |
CTD |
PMID:17346280 |
|
NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192
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|
G |
Mdc1 |
mediator of DNA damage checkpoint 1 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of MDC1 protein |
CTD |
PMID:34122009 |
|
NCBI chr20:2,893,693...2,912,394
Ensembl chr20:2,895,505...2,910,240
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|
G |
Mdh1 |
malate dehydrogenase 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of MDH1 protein |
CTD |
PMID:34122009 |
|
NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925
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G |
Mfn2 |
mitofusin 2 |
decreases expression multiple interactions |
EXP |
Clozapine results in decreased expression of MFN2 protein PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of MFN2 protein] |
CTD |
PMID:37087062 |
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NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
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G |
Mlkl |
mixed lineage kinase domain like pseudokinase |
increases expression |
ISO |
Clozapine results in increased expression of MLKL protein |
CTD |
PMID:31220554 |
|
NCBI chr19:39,277,526...39,304,555
Ensembl chr19:39,276,785...39,304,502
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G |
Mmp10 |
matrix metallopeptidase 10 |
decreases expression |
ISO |
Clozapine results in decreased expression of MMP10 mRNA |
CTD |
PMID:17346280 |
|
NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
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G |
Mmp14 |
matrix metallopeptidase 14 |
increases expression |
ISO |
Clozapine results in increased expression of MMP14 protein |
CTD |
PMID:36482696 |
|
NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
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G |
Mmp7 |
matrix metallopeptidase 7 |
decreases expression |
ISO |
Clozapine results in decreased expression of MMP7 mRNA |
CTD |
PMID:17346280 |
|
NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
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G |
Mobp |
myelin-associated oligodendrocyte basic protein |
increases expression |
ISO |
Clozapine results in increased expression of MOBP mRNA |
CTD |
PMID:15542763 PMID:17266109 |
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NCBI chr 8:119,869,504...119,899,605
Ensembl chr 8:119,869,626...119,899,563
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G |
Mpo |
myeloperoxidase |
affects response to substance increases activity multiple interactions increases oxidation |
ISO |
MPO protein affects the susceptibility to Clozapine Clozapine results in increased activity of MPO protein Clozapine promotes the reaction [[MPO protein results in increased metabolism of chlorodimedone] which results in increased abundance of Hypochlorous Acid]; Clozapine promotes the reaction [MPO protein results in increased abundance of Hypochlorous Acid] MPO protein results in increased oxidation of Clozapine |
CTD |
PMID:24588327 PMID:35575633 |
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NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Mpp3 |
MAGUK p55 scaffold protein 3 |
decreases expression |
ISO |
Clozapine results in decreased expression of MPP3 mRNA |
CTD |
PMID:17266109 |
|
NCBI chr10:86,945,705...86,975,261
Ensembl chr10:86,945,714...86,974,737
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G |
Mr1 |
major histocompatibility complex, class I-related |
affects expression |
ISO |
Clozapine affects the expression of MR1 mRNA |
CTD |
PMID:25811541 |
|
NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970
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G |
Mta2 |
metastasis associated 1 family, member 2 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of MTA2 protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:205,838,181...205,846,903
Ensembl chr 1:205,837,964...205,846,946
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G |
Mtdh |
metadherin |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of MTDH protein |
CTD |
PMID:34122009 |
|
NCBI chr 7:65,306,464...65,365,647
Ensembl chr 7:65,306,400...65,364,413
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G |
Mthfr |
methylenetetrahydrofolate reductase |
affects response to substance |
ISO |
MTHFR gene polymorphism affects the susceptibility to Clozapine; MTHFR protein affects the susceptibility to Clozapine |
CTD |
PMID:20547447 |
|
NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
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G |
Myadm |
myeloid-associated differentiation marker |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of MYADM protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:65,864,180...65,874,701
Ensembl chr 1:65,864,173...65,874,035
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G |
Mybbp1a |
MYB binding protein 1a |
increases expression |
ISO |
Clozapine results in increased expression of MYBBP1A protein |
CTD |
PMID:34122009 |
|
NCBI chr10:57,056,897...57,067,258
Ensembl chr10:57,056,874...57,067,255
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G |
Myh10 |
myosin heavy chain 10 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of MYH10 protein |
CTD |
PMID:34122009 |
|
NCBI chr10:53,393,901...53,525,174
Ensembl chr10:53,394,389...53,525,165
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G |
Myh3 |
myosin heavy chain 3 |
increases expression |
ISO |
Clozapine results in increased expression of MYH3 protein |
CTD |
PMID:34122009 |
|
NCBI chr10:51,770,177...51,793,994
Ensembl chr10:51,770,177...51,793,992
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G |
Myl1 |
myosin, light chain 1 |
increases expression |
ISO |
Clozapine results in increased expression of MYL1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 9:68,437,514...68,458,256
Ensembl chr 9:68,437,517...68,458,261
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G |
Naa10 |
N(alpha)-acetyltransferase 10, NatA catalytic subunit |
decreases expression |
ISO |
Clozapine results in decreased expression of NAA10 protein |
CTD |
PMID:34122009 |
|
NCBI chr X:151,656,056...151,661,304
Ensembl chr X:151,656,056...151,661,252
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G |
Nap1l4 |
nucleosome assembly protein 1-like 4 |
increases expression |
ISO |
Clozapine results in increased expression of NAP1L4 protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:198,709,697...198,746,093
Ensembl chr 1:198,709,701...198,746,020
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G |
Nat10 |
N-acetyltransferase 10 |
decreases expression |
ISO |
Clozapine results in decreased expression of NAT10 protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:90,111,643...90,149,891
Ensembl chr 3:90,111,645...90,149,927
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G |
Ncan |
neurocan |
decreases expression |
ISO |
Clozapine results in decreased expression of NCAN mRNA |
CTD |
PMID:18797397 |
|
NCBI chr16:19,301,969...19,328,436
Ensembl chr16:19,301,969...19,328,436
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G |
Ncapg |
non-SMC condensin I complex, subunit G |
increases expression |
ISO |
Clozapine results in increased expression of NCAPG protein |
CTD |
PMID:34122009 |
|
NCBI chr14:65,403,930...65,432,902
Ensembl chr14:65,404,163...65,432,902
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G |
Ncaph |
non-SMC condensin I complex, subunit H |
decreases expression |
ISO |
Clozapine results in decreased expression of NCAPH protein |
CTD |
PMID:34122009 PMID:36482696 |
|
NCBI chr 3:114,371,937...114,399,178
Ensembl chr 3:114,371,941...114,399,180
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G |
Ncbp1 |
nuclear cap binding protein subunit 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of NCBP1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 5:60,416,023...60,449,004
Ensembl chr 5:60,415,982...60,449,089
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G |
Ncl |
nucleolin |
increases expression |
ISO |
Clozapine results in increased expression of NCL mRNA |
CTD |
PMID:14647396 |
|
NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136
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G |
Ncoa4 |
nuclear receptor coactivator 4 |
increases expression |
ISO |
Clozapine results in increased expression of NCOA4 protein |
CTD |
PMID:36482696 |
|
NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641 Ensembl chr16:7,366,542...7,409,641
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G |
Ndufv2 |
NADH:ubiquinone oxidoreductase core subunit V2 |
increases expression |
EXP |
Clozapine results in increased expression of NDUFV2 mRNA |
CTD |
PMID:19441803 |
|
NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713
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G |
Nectin2 |
nectin cell adhesion molecule 2 |
decreases expression |
ISO |
Clozapine results in decreased expression of NECTIN2 protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:79,372,123...79,407,379
Ensembl chr 1:79,372,119...79,407,360
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G |
Nedd4 |
NEDD4 E3 ubiquitin protein ligase |
decreases expression |
ISO |
Clozapine results in decreased expression of NEDD4 mRNA |
CTD |
PMID:18797397 |
|
NCBI chr 8:73,384,095...73,468,951
Ensembl chr 8:73,383,695...73,468,951
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G |
Nes |
nestin |
decreases expression |
ISO |
Clozapine results in decreased expression of NES protein |
CTD |
PMID:34122009 |
|
NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
affects response to substance |
ISO |
NFE2L2 protein affects the susceptibility to Clozapine |
CTD |
PMID:21540358 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
decreases expression |
EXP |
Clozapine results in decreased expression of NFKB1 protein |
CTD |
PMID:16500086 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Ngfr |
nerve growth factor receptor |
decreases expression |
ISO EXP |
Clozapine results in decreased expression of NGFR protein; Clozapine results in decreased expression of NGFR protein alternative form Clozapine results in decreased expression of NGFR mRNA |
CTD |
PMID:12111809 PMID:14598305 PMID:16513140 |
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NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
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G |
Nifk |
nucleolar protein interacting with the FHA domain of MKI67 |
decreases expression |
ISO |
Clozapine results in decreased expression of NIFK protein |
CTD |
PMID:34122009 |
|
NCBI chr13:29,393,303...29,403,387
Ensembl chr13:29,393,286...29,405,896
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G |
Nnmt |
nicotinamide N-methyltransferase |
increases expression |
ISO |
Clozapine results in increased expression of NNMT protein |
CTD |
PMID:34122009 |
|
NCBI chr 8:48,928,663...48,947,734
Ensembl chr 8:48,933,598...48,946,655
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G |
Nnt |
nicotinamide nucleotide transhydrogenase |
decreases expression |
ISO |
Clozapine results in decreased expression of NNT protein |
CTD |
PMID:34122009 |
|
NCBI chr 2:51,411,413...51,505,125
Ensembl chr 2:51,411,413...51,504,823
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G |
Noc2l |
NOC2-like nucleolar associated transcriptional repressor |
increases expression |
ISO |
Clozapine results in increased expression of NOC2L protein |
CTD |
PMID:34122009 |
|
NCBI chr 5:166,820,150...166,831,949
Ensembl chr 5:166,820,161...166,831,949
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G |
Nomo1 |
Nodal modulator 1 |
increases expression |
ISO |
Clozapine results in increased expression of NOMO3 protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:96,505,460...96,556,280
Ensembl chr 1:96,505,484...96,556,279
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G |
Nop53 |
NOP53 ribosome biogenesis factor |
affects expression |
ISO |
Clozapine affects the expression of NOP53 mRNA |
CTD |
PMID:14647396 |
|
NCBI chr 1:76,629,084...76,636,902
Ensembl chr 1:76,629,069...76,636,902
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G |
Notch2 |
notch receptor 2 |
increases expression |
ISO |
Clozapine results in increased expression of NOTCH2 protein |
CTD |
PMID:36482696 |
|
NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088
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G |
Nploc4 |
NPL4 homolog, ubiquitin recognition factor |
decreases expression |
ISO |
Clozapine results in decreased expression of NPLOC4 protein |
CTD |
PMID:34122009 |
|
NCBI chr10:105,654,395...105,709,958
Ensembl chr10:105,654,812...105,709,913
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G |
Nptn |
neuroplastin |
increases expression |
ISO |
Clozapine results in increased expression of NPTN mRNA |
CTD |
PMID:18797397 |
|
NCBI chr 8:58,996,873...59,063,402
Ensembl chr 8:58,996,887...59,063,401
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G |
Nptx2 |
neuronal pentraxin 2 |
decreases expression |
EXP |
Clozapine results in decreased expression of NPTX2 mRNA |
CTD |
PMID:18208916 |
|
NCBI chr12:10,037,435...10,048,345
Ensembl chr12:10,037,435...10,048,345
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G |
Npy |
neuropeptide Y |
decreases expression |
EXP |
Clozapine results in decreased expression of NPY mRNA |
CTD |
PMID:16516965 |
|
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
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G |
Nqo2 |
N-ribosyldihydronicotinamide:quinone dehydrogenase 2 |
affects response to substance increases reduction multiple interactions |
ISO |
NQO2 gene SNP affects the susceptibility to Clozapine NQO2 protein results in increased reduction of Clozapine metabolite Clozapine inhibits the reaction [NQO2 protein results in increased reduction of Vitamin K 3] |
CTD |
PMID:14617031 PMID:29281794 |
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NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320
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G |
Nr0b2 |
nuclear receptor subfamily 0, group B, member 2 |
increases expression |
ISO |
Clozapine results in increased expression of NR0B2 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
|
NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]] |
CTD |
PMID:21402137 |
|
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
multiple interactions |
ISO |
Clozapine inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein] |
CTD |
PMID:16581232 |
|
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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G |
Nr4a1 |
nuclear receptor subfamily 4, group A, member 1 |
increases expression decreases expression |
EXP |
Clozapine results in increased expression of NR4A1 mRNA Clozapine results in decreased expression of NR4A1 mRNA |
CTD |
PMID:10987852 PMID:11564422 PMID:19695244 |
|
NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
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G |
Nr4a2 |
nuclear receptor subfamily 4, group A, member 2 |
increases expression |
ISO |
Clozapine results in increased expression of NR4A2 mRNA |
CTD |
PMID:17266109 |
|
NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
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G |
Nrg1 |
neuregulin 1 |
increases expression affects expression affects response to substance |
ISO EXP |
Clozapine results in increased expression of NRG1 mRNA Clozapine affects the expression of NRG1 protein NRG1 protein affects the susceptibility to Clozapine |
CTD |
PMID:15706234 PMID:18184445 PMID:19502011 |
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NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884
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G |
Nsf |
N-ethylmaleimide sensitive factor, vesicle fusing ATPase |
decreases expression |
ISO |
Clozapine results in decreased expression of NSF protein |
CTD |
PMID:34122009 |
|
NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386
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G |
Ntng2 |
netrin G2 |
increases expression |
EXP |
Clozapine results in increased expression of NTNG2 mRNA |
CTD |
PMID:17507910 |
|
NCBI chr 3:12,492,574...12,551,104
Ensembl chr 3:12,492,639...12,545,890
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G |
Nts |
neurotensin |
increases expression |
EXP |
Clozapine results in increased expression of NTS mRNA |
CTD |
PMID:12887421 |
|
NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
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G |
Numa1 |
nuclear mitotic apparatus protein 1 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of NUMA1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:156,297,907...156,372,855
Ensembl chr 1:156,326,259...156,372,855
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G |
Numbl |
NUMB-like, endocytic adaptor protein |
decreases expression |
ISO |
Clozapine results in decreased expression of NUMBL mRNA |
CTD |
PMID:18797397 |
|
NCBI chr 1:82,549,814...82,573,788
Ensembl chr 1:82,550,054...82,573,776
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G |
Nup160 |
nucleoporin 160 |
increases expression |
ISO |
Clozapine results in increased expression of NUP160 protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:76,665,786...76,729,296
Ensembl chr 3:76,665,786...76,724,565
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G |
Nup50 |
nucleoporin 50 |
increases expression |
ISO |
Clozapine results in increased expression of NUP50 protein |
CTD |
PMID:34122009 |
|
NCBI chr 7:116,047,960...116,065,231
Ensembl chr 7:116,048,021...116,066,905
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G |
Nup54 |
nucleoporin 54 |
decreases expression |
ISO |
Clozapine results in decreased expression of NUP54 protein |
CTD |
PMID:34122009 |
|
NCBI chr14:15,617,630...15,636,029
Ensembl chr14:15,617,679...15,636,028
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|
G |
Nupr1 |
nuclear protein 1, transcriptional regulator |
increases expression |
ISO |
Clozapine results in increased expression of NUPR1 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
|
NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281
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G |
Osbpl8 |
oxysterol binding protein-like 8 |
increases expression |
ISO |
Clozapine results in increased expression of OSBPL8 mRNA |
CTD |
PMID:14647396 |
|
NCBI chr 7:46,596,944...46,749,888
Ensembl chr 7:46,596,983...46,749,888
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G |
Oxt |
oxytocin/neurophysin I prepropeptide |
affects response to substance |
ISO |
OXT protein affects the susceptibility to Clozapine |
CTD |
PMID:20196918 |
|
NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490
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|
G |
Pakap |
paralemmin A kinase anchor protein |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of PALM2AKAP2 protein |
CTD |
PMID:34122009 |
|
NCBI chr 5:72,536,986...72,648,524 NCBI chr 5:72,313,646...72,450,645
Ensembl chr 5:72,181,718...72,648,524
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|
G |
Pank3 |
pantothenate kinase 3 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in increased expression of PANK3 protein |
CTD |
PMID:34122009 |
|
NCBI chr10:20,229,129...20,252,955
Ensembl chr10:20,229,129...20,252,955
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|
G |
Park7 |
Parkinsonism associated deglycase |
increases expression |
ISO |
Clozapine results in increased expression of PARK7 mRNA |
CTD |
PMID:14647396 |
|
NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
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|
G |
Pcbp1 |
poly(rC) binding protein 1 |
increases expression |
ISO |
Clozapine results in increased expression of PCBP1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 4:118,972,698...118,974,705
Ensembl chr 4:118,972,661...118,976,500
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|
G |
Pck2 |
phosphoenolpyruvate carboxykinase 2 (mitochondrial) |
decreases expression |
ISO |
Clozapine results in decreased expression of PCK2 protein |
CTD |
PMID:34122009 |
|
NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283
|
|
G |
Pclo |
piccolo (presynaptic cytomatrix protein) |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of PCLO protein |
CTD |
PMID:34122009 |
|
NCBI chr 4:19,691,439...20,050,015
Ensembl chr 4:19,695,315...20,049,885
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G |
Pcm1 |
pericentriolar material 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of PCM1 mRNA |
CTD |
PMID:19048012 |
|
NCBI chr16:51,008,315...51,105,261
Ensembl chr16:51,008,315...51,105,091
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G |
Pcnp |
PEST proteolytic signal containing nuclear protein |
increases expression |
ISO |
Clozapine results in increased expression of PCNP protein |
CTD |
PMID:34122009 |
|
NCBI chr11:44,592,766...44,607,372
Ensembl chr11:44,592,742...44,607,348
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|
G |
Pcsk1n |
proprotein convertase subtilisin/kexin type 1 inhibitor |
affects expression |
ISO |
Clozapine affects the expression of PCSK1N mRNA |
CTD |
PMID:14647396 |
|
NCBI chr X:14,580,036...14,583,478
Ensembl chr X:14,580,038...14,583,566
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|
G |
Pdcd11 |
programmed cell death 11 |
increases expression |
ISO |
Clozapine results in increased expression of PDCD11 protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:245,980,840...246,021,999
Ensembl chr 1:245,980,880...246,021,999
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|
G |
Pde10a |
phosphodiesterase 10A |
increases expression |
ISO EXP |
Clozapine results in increased expression of PDE10A mRNA Clozapine results in increased expression of PDE10A mRNA; Clozapine results in increased expression of PDE10A protein |
CTD |
PMID:17266109 PMID:18222493 |
|
NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563
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G |
Pde1b |
phosphodiesterase 1B |
increases expression |
ISO |
Clozapine results in increased expression of PDE1B mRNA |
CTD |
PMID:14647396 |
|
NCBI chr 7:134,627,378...134,654,581
Ensembl chr 7:134,627,322...134,654,580
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G |
Pde4a |
phosphodiesterase 4A |
decreases expression |
EXP |
Clozapine results in decreased expression of PDE4A protein |
CTD |
PMID:20222156 |
|
NCBI chr 8:19,690,816...19,753,538
Ensembl chr 8:19,703,290...19,751,961
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G |
Pde4b |
phosphodiesterase 4B |
decreases expression increases expression |
EXP |
Clozapine results in decreased expression of PDE4B protein Clozapine results in increased expression of PDE4B mRNA; Clozapine results in increased expression of PDE4B protein |
CTD |
PMID:18222493 PMID:20222156 |
|
NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696
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G |
Pdia3 |
protein disulfide isomerase family A, member 3 |
decreases expression |
ISO |
Clozapine results in decreased expression of PDIA3 protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236
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G |
Pdia4 |
protein disulfide isomerase family A, member 4 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of PDIA4 protein |
CTD |
PMID:34122009 |
|
NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107
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G |
Pdlim5 |
PDZ and LIM domain 5 |
decreases expression |
ISO |
Clozapine results in decreased expression of PDLIM5 protein |
CTD |
PMID:34122009 |
|
NCBI chr 2:230,952,251...231,120,329
Ensembl chr 2:230,952,248...231,120,275
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G |
Pebp1 |
phosphatidylethanolamine binding protein 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of PEBP1 protein |
CTD |
PMID:34122009 |
|
NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862
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G |
Penk |
proenkephalin |
decreases expression increases expression |
EXP |
Clozapine results in decreased expression of PENK mRNA Clozapine results in increased expression of PENK mRNA |
CTD |
PMID:1635659 PMID:12887421 |
|
NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
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G |
Pfdn5 |
prefoldin subunit 5 |
increases expression |
ISO |
Clozapine results in increased expression of PFDN5 mRNA |
CTD |
PMID:14647396 |
|
NCBI chr 7:133,451,778...133,456,516
Ensembl chr 7:133,451,453...133,456,516
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G |
Pfkp |
phosphofructokinase, platelet |
increases expression |
EXP |
Clozapine results in increased expression of PFKP mRNA |
CTD |
PMID:15860345 |
|
NCBI chr17:63,729,743...63,794,026
Ensembl chr17:63,729,780...63,794,018
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G |
Pgam5 |
PGAM family member 5, mitochondrial serine/threonine protein phosphatase |
decreases expression |
ISO |
Clozapine results in decreased expression of PGAM5 protein |
CTD |
PMID:34122009 |
|
NCBI chr12:46,409,324...46,416,410
Ensembl chr12:46,409,369...46,416,420
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G |
Pgk1 |
phosphoglycerate kinase 1 |
increases expression |
EXP |
Clozapine results in increased expression of PGK1 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr X:71,271,454...71,287,429
Ensembl chr X:71,271,440...71,287,418
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G |
Pgrmc1 |
progesterone receptor membrane component 1 |
multiple interactions |
EXP |
PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of GLP1R protein]; PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of MFN2 protein] |
CTD |
PMID:37087062 |
|
NCBI chr X:115,832,865...115,841,060
Ensembl chr X:115,832,884...115,888,682
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G |
Phactr1 |
phosphatase and actin regulator 1 |
increases expression |
ISO |
Clozapine results in increased expression of PHACTR1 mRNA |
CTD |
PMID:14647396 |
|
NCBI chr17:21,560,364...22,040,166
Ensembl chr17:21,562,721...22,039,831
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G |
Phf14 |
PHD finger protein 14 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of PHF14 protein |
CTD |
PMID:34122009 |
|
NCBI chr 4:40,009,691...40,195,877
Ensembl chr 4:40,009,264...40,195,885
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|
G |
Pik3r3 |
phosphoinositide-3-kinase regulatory subunit 3 |
decreases expression |
EXP |
Clozapine results in decreased expression of PIK3R3 mRNA |
CTD |
PMID:16715494 |
|
NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583
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G |
Pitpnb |
phosphatidylinositol transfer protein, beta |
increases expression |
ISO |
Clozapine results in increased expression of PITPNB protein |
CTD |
PMID:34122009 |
|
NCBI chr12:45,249,308...45,298,388
Ensembl chr12:45,249,333...45,298,314
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G |
Pkib |
cAMP-dependent protein kinase inhibitor beta |
decreases expression |
EXP |
Clozapine results in decreased expression of PKIB mRNA |
CTD |
PMID:15860345 |
|
NCBI chr20:36,965,172...37,062,190
Ensembl chr20:36,905,340...37,062,187
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G |
Pkm |
pyruvate kinase M1/2 |
increases expression |
EXP |
Clozapine results in increased expression of PKM mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
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G |
Plcb1 |
phospholipase C beta 1 |
increases expression |
ISO |
Clozapine results in increased expression of PLCB1 mRNA |
CTD |
PMID:16465460 |
|
NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869
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|
G |
Plp1 |
proteolipid protein 1 |
decreases expression increases expression |
ISO |
Clozapine results in decreased expression of PLP1 mRNA Clozapine results in increased expression of PLP1 mRNA |
CTD |
PMID:17266109 PMID:18797397 |
|
NCBI chr X:100,184,039...100,201,035
Ensembl chr X:100,185,767...100,201,032
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G |
Pls3 |
plastin 3 |
decreases expression |
ISO |
Clozapine results in decreased expression of PLS3 protein |
CTD |
PMID:34122009 |
|
NCBI chr X:111,589,193...111,683,908
Ensembl chr X:111,589,254...111,683,891
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G |
Pnma1 |
PNMA family member 1 |
increases expression |
ISO |
Clozapine results in increased expression of PNMA1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 6:103,782,244...103,784,029
Ensembl chr 6:103,773,889...103,784,567
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G |
Pon3 |
paraoxonase 3 |
increases expression |
ISO |
Clozapine results in increased expression of PON3 protein |
CTD |
PMID:34122009 |
|
NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855
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G |
Ppa1 |
inorganic pyrophosphatase 1 |
increases expression |
ISO |
Clozapine results in increased expression of PPA1 protein |
CTD |
PMID:34122009 |
|
NCBI chr20:29,590,733...29,617,711
Ensembl chr20:29,590,707...29,619,215
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions increases expression |
ISO |
Berberine inhibits the reaction [Clozapine results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of PPARG protein] Clozapine results in increased expression of PPARG mRNA; Clozapine results in increased expression of PPARG protein |
CTD |
PMID:20564506 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ppm1a |
protein phosphatase, Mg2+/Mn2+ dependent, 1A |
decreases expression |
EXP |
Clozapine results in decreased expression of PPM1A mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 6:91,439,094...91,486,139
Ensembl chr 6:91,438,834...91,480,697
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G |
Ppm1b |
protein phosphatase, Mg2+/Mn2+ dependent, 1B |
decreases expression |
EXP |
Clozapine results in decreased expression of PPM1B mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 6:9,646,695...9,707,471
Ensembl chr 6:9,655,765...9,707,974
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G |
Ppp1cb |
protein phosphatase 1 catalytic subunit beta |
decreases expression |
EXP |
Clozapine results in decreased expression of PPP1CB mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 6:23,958,813...23,992,841
Ensembl chr 6:23,960,998...23,992,824
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G |
Ppp1cc |
protein phosphatase 1 catalytic subunit gamma |
decreases expression |
EXP |
Clozapine results in decreased expression of PPP1CC mRNA |
CTD |
PMID:15860345 |
|
NCBI chr12:34,383,072...34,400,553
Ensembl chr12:34,383,072...34,400,553
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G |
Ppp1r14b |
protein phosphatase 1, regulatory (inhibitor) subunit 14B |
decreases expression |
ISO |
Clozapine results in decreased expression of PPP1R14B protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:204,165,210...204,167,320
Ensembl chr 1:204,163,299...204,167,319 Ensembl chr12:204,163,299...204,167,319
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|
G |
Ppp1r1a |
protein phosphatase 1, regulatory (inhibitor) subunit 1A |
decreases expression |
EXP |
Clozapine results in decreased expression of PPP1R1A mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 7:134,654,578...134,662,236
Ensembl chr 7:134,654,579...134,662,230
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G |
Ppp1r1b |
protein phosphatase 1, regulatory (inhibitor) subunit 1B |
multiple interactions increases phosphorylation |
ISO |
Clozapine inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; Clozapine inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein] Clozapine results in increased phosphorylation of PPP1R1B protein |
CTD |
PMID:11880652 PMID:12871586 |
|
NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775
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G |
Ppp1r2 |
protein phosphatase 1, regulatory (inhibitor) subunit 2 |
decreases expression |
EXP |
Clozapine results in decreased expression of PPP1R2 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr11:69,472,676...69,494,468
Ensembl chr11:69,472,555...69,494,463
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G |
Ppp1r9b |
protein phosphatase 1, regulatory subunit 9B |
increases expression |
EXP |
Clozapine results in increased expression of PPP1R9B protein |
CTD |
PMID:16844384 |
|
NCBI chr10:79,938,055...79,954,085
Ensembl chr10:79,938,066...79,954,083
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G |
Ppp2ca |
protein phosphatase 2 catalytic subunit alpha |
decreases expression |
EXP |
Clozapine results in decreased expression of PPP2CA mRNA |
CTD |
PMID:15860345 |
|
NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862
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G |
Ppp2cb |
protein phosphatase 2 catalytic subunit beta |
decreases expression |
EXP |
Clozapine results in decreased expression of PPP2CB mRNA |
CTD |
PMID:15860345 |
|
NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576
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G |
Ppp2r1a |
protein phosphatase 2 scaffold subunit A alpha |
increases expression |
EXP |
Clozapine results in increased expression of PPP2R1A mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129
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G |
Ppp2r2a |
protein phosphatase 2, regulatory subunit B, alpha |
decreases expression |
EXP |
Clozapine results in decreased expression of PPP2R2A mRNA |
CTD |
PMID:15860345 |
|
NCBI chr15:41,204,659...41,263,924
Ensembl chr15:41,204,200...41,263,924
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G |
Ppp3ca |
protein phosphatase 3 catalytic subunit alpha |
multiple interactions increases expression decreases expression |
EXP |
[Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein Clozapine results in increased expression of PPP3CA mRNA Clozapine results in decreased expression of PPP3CA mRNA; Clozapine results in decreased expression of PPP3CA protein |
CTD |
PMID:12437575 PMID:16033416 |
|
NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
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G |
Ppp4r2 |
protein phosphatase 4, regulatory subunit 2 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in increased expression of PPP4R2 protein |
CTD |
PMID:34122009 |
|
NCBI chr 4:133,454,555...133,495,486
Ensembl chr 4:133,454,555...133,495,486
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G |
Ppp5c |
protein phosphatase 5, catalytic subunit |
affects expression |
ISO |
Clozapine affects the expression of PPP5C mRNA |
CTD |
PMID:14647396 |
|
NCBI chr 1:77,690,203...77,714,507
Ensembl chr 1:77,690,208...77,714,456
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G |
Prdx1 |
peroxiredoxin 1 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in increased expression of PRDX1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856
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G |
Prkaca |
protein kinase cAMP-activated catalytic subunit alpha |
increases expression |
EXP |
Clozapine results in increased expression of PRKACA mRNA |
CTD |
PMID:15860345 |
|
NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
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G |
Prkacb |
protein kinase cAMP-activated catalytic subunit beta |
decreases expression increases expression |
EXP |
Clozapine results in decreased expression of PRKACB mRNA; Clozapine results in decreased expression of PRKACB protein Clozapine results in increased expression of PRKACB mRNA |
CTD |
PMID:11907174 PMID:15860345 |
|
NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198
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G |
Prkar2a |
protein kinase cAMP-dependent type II regulatory subunit alpha |
multiple interactions decreases expression |
EXP ISO |
Clozapine inhibits the reaction [Cyclic AMP binds to PRKAR2A protein] [Cuprizone co-treated with Clozapine] results in decreased expression of PRKAR2A protein Clozapine results in decreased expression of PRKAR2A mRNA; Clozapine results in decreased expression of PRKAR2A protein |
CTD |
PMID:11907174 PMID:34122009 |
|
NCBI chr 8:109,393,189...109,458,832
Ensembl chr 8:109,395,833...109,455,628
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G |
Prkar2b |
protein kinase cAMP-dependent type II regulatory subunit beta |
decreases expression multiple interactions |
EXP |
Clozapine results in decreased expression of PRKAR2B mRNA; Clozapine results in decreased expression of PRKAR2B protein Clozapine inhibits the reaction [Cyclic AMP binds to PRKAR2B protein] |
CTD |
PMID:11907174 PMID:15860345 |
|
NCBI chr 6:48,563,659...48,653,933
Ensembl chr 6:48,563,662...48,653,933
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G |
Prkcb |
protein kinase C, beta |
affects expression increases expression |
EXP |
Clozapine affects the expression of PRKCB protein Clozapine results in increased expression of PRKCB mRNA |
CTD |
PMID:15860345 PMID:15967061 |
|
NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
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G |
Prkce |
protein kinase C, epsilon |
increases expression |
EXP |
Clozapine results in increased expression of PRKCE mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
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G |
Prkcz |
protein kinase C, zeta |
increases expression |
EXP |
Clozapine results in increased expression of PRKCZ mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
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G |
Prl |
prolactin |
increases secretion increases expression multiple interactions |
ISO EXP |
Clozapine results in increased secretion of PRL protein Clozapine analog results in increased expression of PRL protein [Clozapine co-treated with DRD2 gene polymorphism] results in increased secretion of PRL protein; [Risperidone co-treated with Clozapine] results in increased expression of PRL protein |
CTD |
PMID:11155212 PMID:11997696 PMID:15286066 PMID:18562423 |
|
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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G |
Prmt1 |
protein arginine methyltransferase 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of PRMT1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345
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G |
Proc |
protein C, inactivator of coagulation factors Va and VIIIa |
increases expression |
ISO |
Clozapine results in increased expression of PROC protein |
CTD |
PMID:20126316 |
|
NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133
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G |
Prpf38b |
pre-mRNA processing factor 38B |
decreases expression |
ISO |
Clozapine results in decreased expression of PRPF38B mRNA |
CTD |
PMID:14647396 |
|
NCBI chr 2:196,553,224...196,562,271
Ensembl chr 2:196,553,225...196,562,250
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|
G |
Prpf6 |
pre-mRNA processing factor 6 |
decreases expression multiple interactions |
ISO |
Clozapine results in decreased expression of PRPF6 protein [Cuprizone co-treated with Clozapine] results in decreased expression of PRPF6 protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:168,706,952...168,771,191
Ensembl chr 3:168,704,299...168,774,991
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|
G |
Prrc2a |
proline-rich coiled-coil 2A |
decreases expression |
ISO |
Clozapine results in decreased expression of PRRC2A mRNA |
CTD |
PMID:18797397 |
|
NCBI chr20:3,658,391...3,674,143
Ensembl chr20:3,658,695...3,674,130
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|
G |
Psmb5 |
proteasome 20S subunit beta 5 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in increased expression of PSMB5 protein |
CTD |
PMID:34122009 |
|
NCBI chr15:28,072,772...28,077,367
Ensembl chr15:28,072,781...28,077,440
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G |
Psmb7 |
proteasome 20S subunit beta 7 |
decreases expression |
ISO |
Clozapine results in decreased expression of PSMB7 protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:22,357,777...22,417,748
Ensembl chr 3:22,354,698...22,417,937
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|
G |
Psmc3 |
proteasome 26S subunit, ATPase 3 |
increases expression |
ISO |
Clozapine results in increased expression of PSMC3 protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:77,031,825...77,037,207
Ensembl chr 3:77,031,825...77,043,358
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|
G |
Psmc5 |
proteasome 26S subunit, ATPase 5 |
increases expression |
ISO |
Clozapine results in increased expression of PSMC5 protein |
CTD |
PMID:34122009 |
|
NCBI chr10:91,187,763...91,193,697
Ensembl chr10:91,187,743...91,213,135
|
|
G |
Psmd14 |
proteasome 26S subunit, non-ATPase 14 |
increases expression |
ISO |
Clozapine results in increased expression of PSMD14 protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:46,254,338...46,347,076
Ensembl chr 3:46,254,330...46,347,076
|
|
G |
Psmd7 |
proteasome 26S subunit, non-ATPase 7 |
increases expression |
ISO |
Clozapine results in increased expression of PSMD7 protein |
CTD |
PMID:34122009 |
|
NCBI chr19:35,494,317...35,501,605
Ensembl chr19:35,494,316...35,501,588
|
|
G |
Ptcd3 |
Pentatricopeptide repeat domain 3 |
increases expression |
ISO |
Clozapine results in increased expression of PTCD3 protein |
CTD |
PMID:34122009 |
|
NCBI chr 4:103,922,440...103,957,445
Ensembl chr 4:103,920,566...103,957,538
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|
G |
Ptgds |
prostaglandin D2 synthase |
decreases expression increases expression |
ISO |
Clozapine results in decreased expression of PTGDS mRNA Clozapine results in increased expression of PTGDS mRNA |
CTD |
PMID:15542763 PMID:17266109 |
|
NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833
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|
G |
Ptk2 |
protein tyrosine kinase 2 |
increases expression |
ISO |
Clozapine results in increased expression of PTK2 protein |
CTD |
PMID:34122009 |
|
NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
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|
G |
Ptma |
prothymosin alpha |
increases expression |
ISO |
Clozapine results in increased expression of PTMA protein |
CTD |
PMID:34122009 |
|
NCBI chr 9:87,176,251...87,180,333
Ensembl chr 9:87,176,230...87,180,333
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|
G |
Ptms |
parathymosin |
increases expression |
ISO |
Clozapine results in increased expression of PTMS mRNA |
CTD |
PMID:14647396 |
|
NCBI chr 4:157,722,384...157,726,575
Ensembl chr 4:157,722,386...157,727,009
|
|
G |
Pvalb |
parvalbumin |
multiple interactions |
EXP |
Clozapine inhibits the reaction [Phencyclidine results in decreased expression of PVALB mRNA] |
CTD |
PMID:12589379 |
|
NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561
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|
G |
Pwp2 |
PWP2, small subunit processome component |
increases expression |
ISO |
Clozapine results in increased expression of PWP2 protein |
CTD |
PMID:34122009 |
|
NCBI chr20:10,499,332...10,512,965
Ensembl chr20:10,499,363...10,513,640
|
|
G |
Pycr1 |
pyrroline-5-carboxylate reductase 1 |
increases expression |
ISO |
Clozapine results in increased expression of PYCR1 protein |
CTD |
PMID:34122009 |
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NCBI chr10:105,917,732...105,922,658
Ensembl chr10:105,917,680...105,922,549
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G |
Qdpr |
quinoid dihydropteridine reductase |
decreases expression |
ISO |
Clozapine results in decreased expression of QDPR protein |
CTD |
PMID:34122009 |
|
NCBI chr14:65,670,251...65,683,853
Ensembl chr14:65,670,131...65,683,854
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G |
Rab12 |
RAB12, member RAS oncogene family |
decreases expression |
EXP |
Clozapine results in decreased expression of RAB12 mRNA |
CTD |
PMID:12437575 |
|
NCBI chr 9:106,480,301...106,506,895
Ensembl chr 9:106,480,301...106,506,910
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G |
Rac1 |
Rac family small GTPase 1 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in increased expression of RAC1 protein |
CTD |
PMID:34122009 |
|
NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
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G |
Rack1 |
receptor for activated C kinase 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of RACK1 protein |
CTD |
PMID:34122009 |
|
NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975
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G |
Ralyl |
RALY RNA binding protein-like |
increases expression |
ISO |
Clozapine results in increased expression of RALYL protein |
CTD |
PMID:34122009 |
|
NCBI chr 2:87,482,747...88,274,329
Ensembl chr 2:87,482,755...88,274,452
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G |
Ran |
RAN, member RAS oncogene family |
decreases expression |
ISO |
Clozapine results in decreased expression of RAN protein |
CTD |
PMID:34122009 |
|
NCBI chr12:27,674,049...27,678,598
Ensembl chr12:27,674,050...27,678,276
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G |
Rap1gds1 |
Rap1 GTPase-GDP dissociation stimulator 1 |
increases expression |
ISO |
Clozapine results in increased expression of RAP1GDS1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 2:227,500,366...227,645,213
Ensembl chr 2:227,500,367...227,645,169
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G |
Rapgef4 |
Rap guanine nucleotide exchange factor 4 |
decreases expression |
ISO |
Clozapine results in decreased expression of RAPGEF4 mRNA |
CTD |
PMID:18797397 |
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NCBI chr 3:56,809,388...57,101,332
Ensembl chr 3:56,809,270...57,102,316
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G |
Rasgrf1 |
RAS protein-specific guanine nucleotide-releasing factor 1 |
affects expression |
EXP |
Clozapine affects the expression of RASGRF1 mRNA |
CTD |
PMID:12437575 |
|
NCBI chr 8:90,445,154...90,574,274
Ensembl chr 8:90,445,154...90,574,269
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G |
Rbbp4 |
RB binding protein 4, chromatin remodeling factor |
decreases expression |
ISO |
Clozapine results in decreased expression of RBBP4 protein |
CTD |
PMID:34122009 |
|
NCBI chr 5:141,655,863...141,675,157
Ensembl chr 5:141,638,421...141,675,284 Ensembl chr 2:141,638,421...141,675,284
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
decreases expression |
EXP |
Clozapine results in decreased expression of RELA protein |
CTD |
PMID:16500086 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Reln |
reelin |
decreases expression multiple interactions decreases methylation |
ISO EXP |
Clozapine results in decreased expression of RELN mRNA Clozapine results in decreased expression of RELN protein Valproic Acid promotes the reaction [Clozapine results in decreased methylation of RELN promoter] |
CTD |
PMID:17266109 PMID:18757738 PMID:19359144 |
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NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
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G |
Rfc5 |
replication factor C subunit 5 |
increases expression |
ISO |
Clozapine results in increased expression of RFC5 protein |
CTD |
PMID:34122009 |
|
NCBI chr12:39,207,484...39,217,041
Ensembl chr12:39,207,484...39,217,312
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G |
Rgs4 |
regulator of G-protein signaling 4 |
increases expression |
EXP ISO |
Clozapine results in increased expression of RGS4 mRNA |
CTD |
PMID:15860345 PMID:17266109 |
|
NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068
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G |
Rgs7 |
regulator of G-protein signaling 7 |
multiple interactions increases expression |
EXP |
[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein] Clozapine results in increased expression of RGS7 mRNA |
CTD |
PMID:18976543 |
|
NCBI chr13:86,979,269...87,408,834
Ensembl chr13:86,979,279...87,408,888
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G |
Rgs8 |
regulator of G-protein signaling 8 |
increases expression |
EXP |
Clozapine results in increased expression of RGS8 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr13:65,804,703...65,848,955
Ensembl chr13:65,804,797...65,846,807
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G |
Rhob |
ras homolog family member B |
increases expression |
ISO |
Clozapine results in increased expression of RHOB protein |
CTD |
PMID:36482696 |
|
NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
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G |
Ric8a |
RIC8 guanine nucleotide exchange factor A |
decreases expression |
ISO |
Clozapine results in decreased expression of RIC8A protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:195,935,162...195,941,469
Ensembl chr 1:195,935,349...195,941,467
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G |
Rnf13 |
ring finger protein 13 |
increases expression |
ISO |
Clozapine results in increased expression of RNF13 protein |
CTD |
PMID:36482696 |
|
NCBI chr 2:141,927,887...142,061,801
Ensembl chr 2:141,927,909...142,061,801
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G |
Rnf20 |
ring finger protein 20 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in increased expression of RNF20 protein |
CTD |
PMID:34122009 |
|
NCBI chr 5:63,976,063...64,001,754
Ensembl chr 5:63,976,045...64,001,754
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G |
Rorb |
RAR-related orphan receptor B |
decreases expression |
EXP |
Clozapine results in decreased expression of RORB mRNA |
CTD |
PMID:11564422 |
|
NCBI chr 1:216,363,629...216,544,390
Ensembl chr 1:216,363,629...216,544,390
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G |
Rpa1 |
replication protein A1 |
decreases expression |
ISO |
Clozapine results in decreased expression of RPA1 protein |
CTD |
PMID:34122009 |
|
NCBI chr10:60,148,869...60,199,970
Ensembl chr10:60,148,793...60,199,949
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G |
Rpl11 |
ribosomal protein L11 |
increases expression |
ISO |
Clozapine results in increased expression of RPL11 protein |
CTD |
PMID:34122009 |
|
NCBI chr 5:148,274,060...148,277,708
Ensembl chr 5:148,274,069...148,277,599
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G |
Rpl19 |
ribosomal protein L19 |
increases expression |
ISO |
Clozapine results in increased expression of RPL19 protein |
CTD |
PMID:34122009 |
|
NCBI chr10:83,022,503...83,026,030
Ensembl chr10:83,019,257...83,052,112
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G |
Rpl30 |
ribosomal protein L30 |
increases expression |
ISO |
Clozapine results in increased expression of RPL30 protein |
CTD |
PMID:34122009 |
|
NCBI chr 7:65,648,266...65,651,401
Ensembl chr 7:65,645,991...65,651,363 Ensembl chr10:65,645,991...65,651,363 Ensembl chr 1:65,645,991...65,651,363
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G |
Rpl5 |
ribosomal protein L5 |
increases expression |
ISO |
Clozapine results in increased expression of RPL5 protein |
CTD |
PMID:34122009 |
|
NCBI chr14:1,843,856...1,850,301
Ensembl chr14:1,843,770...1,850,290
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G |
Rplp0l1 |
ribosomal protein lateral stalk subunit P0 like 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of RPLP0P6 protein |
CTD |
PMID:34122009 |
|
NCBI chr 2:191,921,503...191,922,661
Ensembl chr 2:191,921,574...191,922,646
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G |
Rplp2 |
ribosomal protein lateral stalk subunit P2 |
increases expression |
ISO |
Clozapine results in increased expression of RPLP2 mRNA |
CTD |
PMID:14647396 |
|
NCBI chr 1:196,546,086...196,548,636
Ensembl chr 1:196,546,352...196,548,645
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G |
Rpn2 |
ribophorin II |
decreases expression |
ISO |
Clozapine results in decreased expression of RPN2 protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:145,941,787...145,989,271
Ensembl chr 3:145,941,839...145,989,543
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G |
Rps10 |
ribosomal protein S10 |
increases expression |
ISO |
Clozapine results in increased expression of RPS10 mRNA |
CTD |
PMID:14647396 |
|
NCBI chr20:5,694,313...5,698,922
Ensembl chr20:5,694,313...5,699,044 Ensembl chr 6:5,694,313...5,699,044 Ensembl chr 6:5,694,313...5,699,044
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G |
Rps11 |
ribosomal protein S11 |
decreases expression |
ISO |
Clozapine results in decreased expression of RPS11 protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:95,605,690...95,607,798
Ensembl chr 1:95,605,692...95,607,874
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G |
Rps3 |
ribosomal protein S3 |
decreases expression |
ISO |
Clozapine results in decreased expression of RPS3 protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:153,778,363...153,783,663
Ensembl chr 1:153,777,472...153,783,680
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G |
Rrbp1 |
ribosome binding protein 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of RRBP1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:131,314,996...131,376,930
Ensembl chr 3:131,314,998...131,376,981
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G |
Rsf1 |
remodeling and spacing factor 1 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of RSF1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:151,892,055...152,015,089
Ensembl chr 1:151,892,434...152,009,051
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G |
Rspry1 |
ring finger and SPRY domain containing 1 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in increased expression of RSPRY1 protein |
CTD |
PMID:34122009 |
|
NCBI chr19:10,352,449...10,403,015
Ensembl chr19:10,353,821...10,401,102
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G |
RT1-A2 |
RT1 class Ia, locus A2 |
increases expression |
ISO |
Clozapine results in increased expression of HLA-E protein |
CTD |
PMID:36482696 |
|
NCBI chr20:4,870,939...4,910,183
|
|
G |
Rtcb |
RNA 2',3'-cyclic phosphate and 5'-OH ligase |
increases expression |
ISO |
Clozapine results in increased expression of RTCB protein |
CTD |
PMID:34122009 |
|
NCBI chr 7:17,907,668...17,927,136
Ensembl chr 7:17,907,705...17,927,132
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G |
Rtn4 |
reticulon 4 |
increases expression |
ISO |
Clozapine results in increased expression of RTN4 mRNA |
CTD |
PMID:17266109 |
|
NCBI chr14:103,450,074...103,497,687
Ensembl chr14:103,449,930...103,497,686
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G |
Rxrg |
retinoid X receptor gamma |
decreases expression |
EXP |
Clozapine results in decreased expression of RXRG mRNA alternative form |
CTD |
PMID:11564422 |
|
NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167
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G |
S100a9 |
S100 calcium binding protein A9 |
decreases expression |
ISO |
Clozapine results in decreased expression of S100A9 mRNA |
CTD |
PMID:18797397 |
|
NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
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G |
Safb |
scaffold attachment factor B |
increases expression |
ISO |
Clozapine results in increased expression of SAFB protein |
CTD |
PMID:34122009 |
|
NCBI chr 9:1,417,449...1,438,408
Ensembl chr 9:1,417,525...1,438,644
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G |
Sars1 |
seryl-tRNA synthetase 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of SARS1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 2:196,065,543...196,081,240
Ensembl chr 2:196,065,430...196,081,277
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G |
Satb2 |
SATB homeobox 2 |
increases expression |
ISO |
Clozapine results in increased expression of SATB2 protein |
CTD |
PMID:34122009 |
|
NCBI chr 9:58,348,027...58,534,256
Ensembl chr 9:58,350,246...58,530,707
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G |
Sc5d |
sterol-C5-desaturase |
increases expression |
ISO |
Clozapine results in increased expression of SC5D mRNA |
CTD |
PMID:17052361 |
|
NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273
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G |
Scd |
stearoyl-CoA desaturase |
increases expression |
ISO |
Clozapine results in increased expression of SCD mRNA |
CTD |
PMID:16027736 PMID:17052361 |
|
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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G |
Sdcbp |
syndecan binding protein |
decreases expression increases expression |
ISO |
Clozapine results in decreased expression of SDCBP protein Clozapine results in increased expression of SDCBP protein |
CTD |
PMID:34122009 PMID:36482696 |
|
NCBI chr 5:19,473,499...19,517,188
Ensembl chr 5:19,489,961...19,527,572
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G |
Sec31a |
SEC31 homolog A, COPII coat complex component |
increases expression |
ISO |
Clozapine results in increased expression of SEC31A protein |
CTD |
PMID:34122009 |
|
NCBI chr14:9,214,324...9,269,281
Ensembl chr14:9,214,349...9,269,273
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G |
Sec61b |
SEC61 translocon subunit beta |
increases expression |
ISO |
Clozapine results in increased expression of SEC61B protein |
CTD |
PMID:34122009 |
|
NCBI chr 5:61,773,594...61,781,804
Ensembl chr 5:61,773,594...61,781,804
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G |
Sec63 |
SEC63 homolog, protein translocation regulator |
increases expression |
ISO |
Clozapine results in increased expression of SEC63 protein |
CTD |
PMID:34122009 |
|
NCBI chr20:46,245,101...46,314,055
Ensembl chr20:46,245,101...46,314,055
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G |
Septin14 |
septin 14 |
decreases expression |
ISO |
Clozapine results in decreased expression of SEPTIN14 protein |
CTD |
PMID:34122009 |
|
NCBI chr12:26,975,283...27,005,588
Ensembl chr12:26,975,344...26,998,299
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G |
Serinc1 |
serine incorporator 1 |
increases expression |
ISO |
Clozapine results in increased expression of SERINC1 protein |
CTD |
PMID:36482696 |
|
NCBI chr20:36,850,062...36,868,999
Ensembl chr20:36,850,076...36,896,691
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G |
Serpina3n |
serpin family A member 3N |
increases expression |
ISO |
Clozapine results in increased expression of SERPINA3 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
|
NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433
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G |
Serpine2 |
serpin family E member 2 |
increases expression |
EXP |
Clozapine results in increased expression of SERPINE2 mRNA; Clozapine results in increased expression of SERPINE2 protein |
CTD |
PMID:15354176 |
|
NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826
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G |
Set |
Set nuclear proto-oncogene |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in increased expression of SET protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:13,334,564...13,345,598
Ensembl chr 3:13,335,041...13,363,567
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G |
Setx |
senataxin |
increases expression |
ISO |
Clozapine results in increased expression of SETX protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:12,428,091...12,480,801
Ensembl chr 3:12,427,635...12,480,803
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G |
Sf3b3 |
splicing factor 3b, subunit 3 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of SF3B3 protein |
CTD |
PMID:34122009 |
|
NCBI chr19:38,782,749...38,820,271
Ensembl chr19:38,783,040...38,820,245
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G |
Sfpq |
splicing factor proline and glutamine rich |
decreases expression |
ISO |
Clozapine results in decreased expression of SFPQ protein |
CTD |
PMID:34122009 |
|
NCBI chr 5:139,338,034...139,353,476
Ensembl chr 5:139,338,075...139,353,472
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G |
Sfxn1 |
sideroflexin 1 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of SFXN1 protein |
CTD |
PMID:34122009 |
|
NCBI chr17:10,486,250...10,522,640
Ensembl chr17:10,486,271...10,522,529
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G |
Sgk1 |
serum/glucocorticoid regulated kinase 1 |
increases expression |
ISO EXP |
Clozapine results in increased expression of SGK1 mRNA |
CTD |
PMID:17266109 PMID:18208916 |
|
NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
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G |
Sh3gl1 |
SH3 domain containing GRB2 like 1, endophilin A2 |
increases expression |
ISO |
Clozapine results in increased expression of SH3GL1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 9:842,285...869,753
Ensembl chr 9:842,288...869,716
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|
G |
Sh3kbp1 |
SH3 domain-containing kinase-binding protein 1 |
increases expression |
ISO |
Clozapine results in increased expression of SH3KBP1 protein |
CTD |
PMID:34122009 |
|
NCBI chr X:34,877,862...35,223,013
Ensembl chr X:34,877,866...35,222,747
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G |
Sh3pxd2b |
SH3 and PX domains 2B |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of SH3PXD2B protein |
CTD |
PMID:34122009 |
|
NCBI chr10:16,918,611...17,027,499
Ensembl chr10:16,918,679...17,005,170
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G |
Sim2 |
SIM bHLH transcription factor 2 |
decreases expression |
ISO |
Clozapine results in decreased expression of SIM2 protein |
CTD |
PMID:34122009 |
|
NCBI chr11:33,414,218...33,453,663
Ensembl chr11:33,414,218...33,453,663
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G |
Sirt2 |
sirtuin 2 |
increases expression |
ISO |
Clozapine results in increased expression of SIRT2 protein |
CTD |
PMID:36482696 |
|
NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975
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G |
Skp1 |
S-phase kinase-associated protein 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of SKP1 protein |
CTD |
PMID:34122009 |
|
NCBI chr10:36,401,987...36,417,066
Ensembl chr10:36,402,153...36,417,388
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G |
Slc17a6 |
solute carrier family 17 member 6 |
increases expression |
ISO |
Clozapine results in increased expression of SLC17A6 mRNA; Clozapine results in increased expression of SLC17A6 protein |
CTD |
PMID:17266109 PMID:18155072 |
|
NCBI chr 1:101,212,489...101,252,543
Ensembl chr 1:101,212,489...101,252,542
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G |
Slc17a7 |
solute carrier family 17 member 7 |
increases expression |
ISO |
Clozapine results in increased expression of SLC17A7 mRNA; Clozapine results in increased expression of SLC17A7 protein |
CTD |
PMID:16111724 |
|
NCBI chr 1:95,649,709...95,661,591
Ensembl chr 1:95,649,745...95,661,588
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G |
Slc18a2 |
solute carrier family 18 member A2 |
increases expression |
EXP |
Clozapine results in increased expression of SLC18A2 mRNA; Clozapine results in increased expression of SLC18A2 protein |
CTD |
PMID:12007678 |
|
NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
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G |
Slc1a1 |
solute carrier family 1 member 1 |
decreases expression |
EXP |
Clozapine results in decreased expression of SLC1A1 mRNA |
CTD |
PMID:12873733 |
|
NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402
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G |
Slc1a2 |
solute carrier family 1 member 2 |
decreases activity decreases expression |
EXP |
Clozapine results in decreased activity of SLC1A2 protein Clozapine results in decreased expression of SLC1A2 mRNA; Clozapine results in decreased expression of SLC1A2 protein |
CTD |
PMID:11443521 PMID:12873733 |
|
NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498
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G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
Clozapine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
|
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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|
G |
Slc22a5 |
solute carrier family 22 member 5 |
multiple interactions |
ISO |
Clozapine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] |
CTD |
PMID:30465787 |
|
NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
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|
G |
Slc25a13 |
solute carrier family 25 member 13 |
increases expression |
ISO |
Clozapine results in increased expression of SLC25A13 protein |
CTD |
PMID:34122009 |
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NCBI chr 4:34,179,224...34,361,912
Ensembl chr 4:34,179,224...34,361,902
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G |
Slc25a24 |
solute carrier family 25 member 24 |
increases expression |
ISO |
Clozapine results in increased expression of SLC25A24 protein |
CTD |
PMID:34122009 |
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NCBI chr 2:196,761,076...196,799,236
Ensembl chr 2:196,761,274...196,799,231
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G |
Slc25a5-ps11 |
solute carrier family 25 member 5, pseudogene 11 |
increases expression |
ISO |
Clozapine results in increased expression of SLC25A6 protein |
CTD |
PMID:34122009 |
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NCBI chr18:68,571,222...68,572,461
Ensembl chr18:68,571,300...68,572,199
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G |
Slc2a3 |
solute carrier family 2 member 3 |
decreases expression |
ISO |
Clozapine results in decreased expression of SLC2A3 mRNA |
CTD |
PMID:15342952 |
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NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
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G |
Slc39a7 |
solute carrier family 39 member 7 |
increases expression |
ISO |
Clozapine results in increased expression of SLC39A7 mRNA |
CTD |
PMID:14647396 |
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NCBI chr20:4,823,166...4,826,538
Ensembl chr20:4,822,012...4,826,537
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G |
Slc3a2 |
solute carrier family 3 member 2 |
increases expression |
ISO |
Clozapine results in increased expression of SLC3A2 protein |
CTD |
PMID:36482696 |
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NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
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G |
Slc6a2 |
solute carrier family 6 member 2 |
decreases expression |
EXP |
Clozapine results in decreased expression of SLC6A2 mRNA |
CTD |
PMID:18923069 |
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NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357
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G |
Slc6a3 |
solute carrier family 6 member 3 |
affects response to substance |
ISO |
SLC6A3 5' UTR affects the susceptibility to Clozapine |
CTD |
PMID:20580759 |
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NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
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G |
Slc6a4 |
solute carrier family 6 member 4 |
multiple interactions increases expression affects response to substance |
ISO EXP |
[SLC6A4 gene polymorphism results in decreased uptake of Serotonin] which results in decreased susceptibility to Clozapine Clozapine results in increased expression of SLC6A4 SLC6A4 protein affects the susceptibility to Clozapine |
CTD |
PMID:12007678 PMID:20452607 |
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NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
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G |
Smarcb1 |
SWI/SNF related BAF chromatin remodeling complex subunit B1 |
decreases expression |
ISO |
Clozapine results in decreased expression of SMARCB1 protein |
CTD |
PMID:34122009 |
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NCBI chr20:12,741,164...12,763,616
Ensembl chr20:12,741,477...12,763,620
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G |
Smarcc2 |
SWI/SNF related BAF chromatin remodeling complex subunit C2 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of SMARCC2 protein |
CTD |
PMID:34122009 |
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NCBI chr 7:881,844...910,090
Ensembl chr 7:881,421...909,978
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G |
Smc2 |
structural maintenance of chromosomes 2 |
decreases expression |
ISO |
Clozapine results in decreased expression of SMC2 protein |
CTD |
PMID:34122009 |
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NCBI chr 5:66,806,882...66,853,478
Ensembl chr 5:66,807,011...66,853,242
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