benzimidazoles - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	benzimidazoles	go back to main search page
Accession:	CHEBI:22715	browse the term
Definition:	An organic heterocyclic compound containing a benzene ring fused to an imidazole ring.
Synonyms:	alt_id:	MESH:D001562
	xref_mesh:	MESH:D001562

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Rat (1176) Mouse (1162) Human (1167) Chinchilla (0) Bonobo (0) Dog (3) Squirrel (0) Pig (5) Green Monkey (0) Naked Mole-rat (0) All
Genes (1176)

benzimidazoles

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

Benzimidazoles promotes the reaction [Cycloheximide results in increased expression of CYP1A1 mRNA]

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

dopamine receptor D2

affects binding

Benzimidazoles analog binds to DRD2 protein

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

5-hydroxytryptamine receptor 2A

affects binding

Benzimidazoles analog binds to HTR2A protein

NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928

G

insulin-like growth factor 2

multiple interactions
decreases response to substance

Benzimidazoles inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]
Benzimidazoles results in decreased susceptibility to IGF2 protein

NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018

G

potassium voltage-gated channel subfamily Q member 2

multiple interactions

[Benzimidazoles analog results in increased activity of [KCNQ3 protein binds to KCNQ2 protein]] which results in increased import of Thallium; [Benzimidazoles analog results in increased activity of KCNQ2 protein] which results in increased import of Thallium; Benzimidazoles analog results in increased activity of [KCNQ3 protein binds to KCNQ2 protein]

NCBI chr 3:168,194,776...168,253,831
Ensembl chr 3:168,195,357...168,275,071

G

potassium voltage-gated channel subfamily Q member 3

multiple interactions

[Benzimidazoles analog results in increased activity of [KCNQ3 protein binds to KCNQ2 protein]] which results in increased import of Thallium; Benzimidazoles analog results in increased activity of [KCNQ3 protein binds to KCNQ2 protein]

NCBI chr 7:97,730,219...98,025,652
Ensembl chr 7:97,730,465...98,025,653

G

5-methyltetrahydrofolate-homocysteine methyltransferase

decreases activity

Benzimidazoles results in decreased activity of MTR protein

NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822

G

steroid sulfatase

multiple interactions

Benzimidazoles inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]

NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402

G

DNA topoisomerase II alpha

decreases activity

Benzimidazoles results in decreased activity of TOP2A protein

NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874

1H-benzimidazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

endothelial PAS domain protein 1

increases stability

benzimidazole results in increased stability of EPAS1 protein

NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228

G

transient receptor potential cation channel, subfamily V, member 1

multiple interactions

benzimidazole analog inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; benzimidazole analog inhibits the reaction [Protons results in increased activity of TRPV1 protein]; capsazepine inhibits the reaction [benzimidazole analog inhibits the reaction [Protons results in increased activity of TRPV1 protein]]; N-(3-methoxyphenyl)-4-chlorocinnamanilide inhibits the reaction [benzimidazole analog inhibits the reaction [Protons results in increased activity of TRPV1 protein]]

NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513

1H-benzo[d]imidazole-2-thiol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

2-mercaptobenzimidazole analog results in increased expression of CYP1A1 protein; 2-mercaptobenzimidazole results in increased expression of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions
decreases activity

bisbenzimide ethoxide trihydrochloride inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
bisbenzimide ethoxide trihydrochloride results in decreased activity of ABCB11 protein

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

increases transport
multiple interactions

ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride
ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride
abamectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; emamectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
[zosuquidar trihydrochloride results in decreased activity of ABCB1 protein] which results in decreased export of bisbenzimide ethoxide trihydrochloride; abamectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; emamectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]

PMID:25865432 PMID:34896433

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 1

multiple interactions
increases transport

abamectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; emamectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily G member 2

decreases abundance
decreases export
decreases activity
multiple interactions
increases export
increases transport

ABCG2 protein results in decreased abundance of bisbenzimide ethoxide trihydrochloride
ABCG2 protein polymorphism results in decreased export of bisbenzimide ethoxide trihydrochloride
bisbenzimide ethoxide trihydrochloride results in decreased activity of ABCG2 protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] which results in decreased export of bisbenzimide ethoxide trihydrochloride; [bisphenol A results in decreased activity of ABCG2 protein] which results in decreased transport of bisbenzimide ethoxide trihydrochloride; [MLN 8237 affects the activity of ABCG2 protein] which affects the export of bisbenzimide ethoxide trihydrochloride; [MYC protein results in increased expression of ABCG2 protein] which results in increased export of bisbenzimide ethoxide trihydrochloride; Cimetidine inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Cyclosporine inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; danofloxacin inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Genistein inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Genistein promotes the reaction [ABCG2 protein polymorphism results in decreased export of bisbenzimide ethoxide trihydrochloride]; Methotrexate inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Nitrofurantoin inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Porphyrins inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Reserpine inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Tobacco Smoke Pollution inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; verlukast inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]

PMID:12869632 PMID:19239227 PMID:26850786 PMID:26907376 PMID:27450509 More...

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

Kelch-like ECH-associated protein 1

decreases export

KEAP1 protein results in decreased export of bisbenzimide ethoxide trihydrochloride

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions

[MYC protein results in increased expression of ABCG2 protein] which results in increased export of bisbenzimide ethoxide trihydrochloride

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

2-aminobenzimidazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

2-aminobenzimidazole results in increased expression of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

5'-hydroxyomeprazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

5-hydroxymethylomeprazole results in increased expression of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

increases expression

Omeprazole results in increased expression of ABCA1 mRNA

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily B member 11

decreases activity

Omeprazole results in decreased activity of ABCB11 protein

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

affects expression
multiple interactions

Omeprazole affects the expression of ABCB1A mRNA
Omeprazole promotes the reaction [Cisplatin results in increased expression of ABCB1A protein]
Omeprazole promotes the reaction [Cisplatin results in increased expression of ABCB1 protein]

PMID:19483382 PMID:30452898

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily B member 4

decreases expression

Omeprazole results in decreased expression of ABCB4 mRNA

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

ATP binding cassette subfamily C member 2

multiple interactions

[Omeprazole results in increased susceptibility to Cisplatin] which results in decreased expression of ABCC2 protein

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

increases expression

Omeprazole results in increased expression of ABCC3 mRNA

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily C member 6

affects expression

Omeprazole affects the expression of ABCC6 mRNA

NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464

G

ATP binding cassette subfamily G member 2

increases expression
multiple interactions

Omeprazole results in increased expression of ABCG2 mRNA alternative form; Omeprazole results in increased expression of ABCG2 protein
Omeprazole inhibits the reaction [ABCG2 protein results in increased transport of lucifer yellow]

PMID:20804740 PMID:31348918

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

ATP binding cassette subfamily G member 5

affects expression

Omeprazole affects the expression of ABCG5 mRNA

NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563

G

abhydrolase domain containing 1

affects expression

Omeprazole affects the expression of ABHD1 mRNA

NCBI chr 6:25,422,526...25,427,514
Ensembl chr 6:25,422,526...25,427,514

G

abhydrolase domain containing 14b

affects expression

Omeprazole affects the expression of ABHD14B mRNA

NCBI chr 8:107,087,157...107,092,122
Ensembl chr 8:107,088,069...107,092,119

G

abhydrolase domain containing 17A, depalmitoylase

affects expression

Omeprazole affects the expression of ABHD17A mRNA

NCBI chr 7:9,124,332...9,132,762
Ensembl chr 7:9,124,332...9,130,762

G

acetyl-CoA carboxylase alpha

affects expression

Omeprazole affects the expression of ACACA mRNA

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

acyl-CoA dehydrogenase, long chain

affects expression

Omeprazole affects the expression of ACADL mRNA

NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220

G

angiotensin converting enzyme 2

decreases expression

Omeprazole results in decreased expression of ACE2 mRNA

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

aconitase 1

affects expression

Omeprazole affects the expression of ACO1 mRNA

NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391

G

aconitase 2

affects expression

Omeprazole affects the expression of ACO2 mRNA

NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261

G

acyl-CoA thioesterase 12

affects expression

Omeprazole affects the expression of ACOT12 mRNA

NCBI chr 2:22,986,867...23,027,538
Ensembl chr 2:22,986,626...23,027,536

G

acyl-CoA thioesterase 4

affects expression

Omeprazole affects the expression of ACOT4 mRNA

NCBI chr 6:103,668,699...103,674,037
Ensembl chr 6:103,668,753...103,673,917

G

ADAM metallopeptidase domain 15

affects expression

Omeprazole affects the expression of ADAM15 mRNA

NCBI chr 2:174,754,629...174,765,136
Ensembl chr 2:174,754,633...174,765,113

G

adducin 1

affects expression

Omeprazole affects the expression of ADD1 mRNA

NCBI chr14:76,108,643...76,167,267
Ensembl chr14:76,108,654...76,167,182

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

decreases expression

Omeprazole results in decreased expression of ADH1C mRNA

NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892

G

alcohol dehydrogenase 4 (class II), pi polypeptide

affects expression

Omeprazole affects the expression of ADH4 mRNA

NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591

G

androgen-dependent TFPI-regulating protein

affects expression

Omeprazole affects the expression of ADTRP mRNA

NCBI chr17:22,907,758...22,993,834
Ensembl chr17:22,930,740...22,993,826

G

afamin

affects expression

Omeprazole affects the expression of AFM mRNA

NCBI chr14:17,531,022...17,563,868
Ensembl chr14:17,531,024...17,563,870

G

angiotensinogen

affects expression

Omeprazole affects the expression of AGT mRNA

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 1a

affects expression

Omeprazole affects the expression of AGTR1A mRNA

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

G

aryl hydrocarbon receptor

multiple interactions
decreases activity
increases activity
increases expression
decreases expression
affects localization
increases response to substance

[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of AHR mRNA; AHR protein promotes the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Omeprazole affects the localization of [ARNT protein co-treated with AHR protein]
Omeprazole results in decreased activity of AHR protein
Omeprazole results in increased activity of AHR protein
Omeprazole results in increased expression of AHR protein
Omeprazole results in decreased expression of AHR mRNA
AG-879 inhibits the reaction [Omeprazole results in increased activity of AHR protein]; AHR protein affects the reaction [Omeprazole results in decreased expression of CXCR4 mRNA]; AHR protein affects the reaction [Omeprazole results in increased expression of HAMP mRNA]; AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A2 mRNA]; AHR protein mutant form inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Omeprazole results in decreased expression of AHR mRNA]; AHR protein promotes the reaction [Omeprazole results in decreased expression of CYP1A1 mRNA]; BMX mRNA affects the reaction [Omeprazole results in increased activity of AHR protein]; Omeprazole binds to and results in increased activity of AHR protein; Omeprazole promotes the reaction [AHR protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [AHR protein binds to CYP1B1 promoter]; omeprazole sulfide inhibits the reaction [Omeprazole results in increased activity of AHR protein]; Puromycin inhibits the reaction [Omeprazole results in increased expression of AHR protein]
Omeprazole affects the localization of AHR protein
AHR protein results in increased susceptibility to Omeprazole

PMID:9139728 PMID:9395520 PMID:14742684 PMID:16109480 PMID:20171196 More...

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aldo-keto reductase family 1 member A1

affects expression

Omeprazole affects the expression of AKR1A1 mRNA

NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674

G

aldo-keto reductase family 7, member A2

affects expression

Omeprazole affects the expression of AKR7A2 mRNA

NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909

G

aldo-keto reductase family 7 member A3

affects expression
multiple interactions

Omeprazole affects the expression of AKR7A3 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of AKR7A3 mRNA

PMID:19483382 PMID:22687989

NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394

G

aldehyde dehydrogenase 1 family, member A1

affects expression
multiple interactions

Omeprazole affects the expression of ALDH1A1 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of ALDH1A1 mRNA

PMID:19483382 PMID:22687989

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 1 family, member A3

increases expression

Omeprazole results in increased expression of ALDH1A3 mRNA

NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436

G

aldehyde dehydrogenase 2 family member

affects expression

Omeprazole affects the expression of ALDH2 mRNA

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

G

aldehyde dehydrogenase 3 family, member A1

increases expression

Omeprazole results in increased expression of ALDH3A1 mRNA

NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681

G

alkB homolog 7

affects expression

Omeprazole affects the expression of ALKBH7 mRNA

NCBI chr 9:1,838,886...1,841,044
Ensembl chr 9:1,838,811...1,841,044

G

adaptor related protein complex 2 subunit mu 1

affects expression

Omeprazole affects the expression of AP2M1 mRNA

NCBI chr11:80,355,307...80,364,218
Ensembl chr11:80,328,041...80,364,140

G

amyloid P component, serum

affects expression

Omeprazole affects the expression of APCS mRNA

NCBI chr13:85,373,219...85,374,195
Ensembl chr13:85,373,220...85,374,298

G

apolipoprotein A4

affects expression

Omeprazole affects the expression of APOA4 mRNA

NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469

G

apolipoprotein H

affects expression

Omeprazole affects the expression of APOH mRNA

NCBI chr10:93,342,435...93,356,334
Ensembl chr10:93,310,977...93,356,329

G

apolipoprotein O-like

affects expression

Omeprazole affects the expression of APOOL mRNA

NCBI chr X:77,377,723...77,443,672
Ensembl chr X:77,377,781...77,443,900

G

arginase 1

affects expression

Omeprazole affects the expression of ARG1 mRNA

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

ARL6 interacting reticulophagy regulator 1

affects expression

Omeprazole affects the expression of ARL6IP1 mRNA

NCBI chr 1:172,430,475...172,439,990
Ensembl chr 1:172,430,489...172,439,994

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions
affects localization

Omeprazole promotes the reaction [ARNT protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [ARNT protein binds to CYP1B1 promoter]
Omeprazole affects the localization of ARNT protein
Omeprazole affects the localization of [ARNT protein co-treated with AHR protein]

PMID:9395520 PMID:21703235 PMID:25826687

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

G

asialoglycoprotein receptor 2

affects expression

Omeprazole affects the expression of ASGR2 mRNA

NCBI chr10:54,821,407...54,834,624
Ensembl chr10:54,821,438...54,834,617

G

activating transcription factor 5

affects expression

Omeprazole affects the expression of ATF5 mRNA

NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707

G

ATP synthase F1 subunit epsilon

affects expression

Omeprazole affects the expression of ATP5F1E mRNA

NCBI chr 3:163,259,072...163,261,974
Ensembl chr 3:163,260,476...163,261,450

G

ATPase H+ transporting accessory protein 2

affects expression

Omeprazole affects the expression of ATP6AP2 mRNA

NCBI chr X:10,183,983...10,210,948
Ensembl chr X:10,183,068...10,210,918

G

ATPase H+ transporting V1 subunit A

affects expression

Omeprazole affects the expression of ATP6V1A mRNA

NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694

G

ATPase H+ transporting V1 subunit F

affects expression

Omeprazole affects the expression of ATP6V1F mRNA

NCBI chr 4:58,067,666...58,070,628

G

ATPase copper transporting alpha

multiple interactions

Omeprazole inhibits the reaction [ATP7A protein results in increased activity of TYR protein]
Omeprazole inhibits the reaction [Copper affects the localization of ATP7A protein]; Omeprazole inhibits the reaction [cupric chloride affects the localization of ATP7A protein]

NCBI chr X:71,094,144...71,201,550
Ensembl chr X:71,094,202...71,198,354

G

bile acid CoA:amino acid N-acyltransferase

affects expression

Omeprazole affects the expression of BAAT mRNA

NCBI chr 5:63,851,668...63,860,641
Ensembl chr 5:63,850,705...63,860,685

G

BCL2 associated X, apoptosis regulator

multiple interactions

Omeprazole inhibits the reaction [Cisplatin results in increased expression of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

Omeprazole inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCL6B, transcription repressor

affects expression

Omeprazole affects the expression of BCL6B mRNA

NCBI chr10:54,940,908...54,947,022
Ensembl chr10:54,940,909...54,945,974

G

bridge-like lipid transfer protein family member 3B

affects expression

Omeprazole affects the expression of BLTP3B mRNA

NCBI chr 7:24,181,635...24,261,720
Ensembl chr 7:24,181,644...24,261,720

G

Bcl2 modifying factor

affects expression

Omeprazole affects the expression of BMF mRNA

NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145

G

BMX non-receptor tyrosine kinase

multiple interactions

BMX mRNA affects the reaction [Omeprazole results in increased activity of AHR protein]

NCBI chr X:30,227,251...30,290,015
Ensembl chr X:30,227,251...30,289,993

G

BCL2 interacting protein 3

affects expression

Omeprazole affects the expression of BNIP3 mRNA

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

basic transcription factor 3

affects expression

Omeprazole affects the expression of BTF3 mRNA

NCBI chr 2:29,659,764...29,666,898
Ensembl chr 2:29,659,231...29,666,879
Ensembl chr13:29,659,231...29,666,879

G

complement C1q A chain

decreases expression

Omeprazole results in decreased expression of C1QA mRNA

NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534

G

complement C1q binding protein

affects expression

Omeprazole affects the expression of C1QBP mRNA

NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649

G

complement C1q C chain

decreases expression

Omeprazole results in decreased expression of C1QC mRNA

NCBI chr 5:149,127,412...149,130,757
Ensembl chr 5:149,127,415...149,131,017

G

complement C1s

affects expression

Omeprazole affects the expression of C1S mRNA

NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303

G

C2 calcium-dependent domain containing 2

affects expression

Omeprazole affects the expression of C2CD2 mRNA

NCBI chr11:37,225,321...37,289,741
Ensembl chr11:37,227,415...37,289,739

G

complement component 4 binding protein, alpha

affects expression
decreases expression

Omeprazole affects the expression of C4BPA mRNA
Omeprazole results in decreased expression of C4BPA mRNA

PMID:19483382 PMID:25626140

NCBI chr13:42,075,715...42,111,205
Ensembl chr13:42,075,717...42,111,205

G

complement component 4 binding protein, beta

decreases expression

Omeprazole results in decreased expression of C4BPB mRNA

NCBI chr13:42,120,798...42,131,515
Ensembl chr13:42,120,798...42,131,817

G

complement C7

affects expression

Omeprazole affects the expression of C7 mRNA

NCBI chr 2:54,088,116...54,165,102
Ensembl chr 2:54,088,116...54,158,535

G

complement C8 beta chain

affects expression

Omeprazole affects the expression of C8B mRNA

NCBI chr 5:119,535,009...119,572,565
Ensembl chr 5:119,535,146...119,572,565

G

calcium dependent secretion activator 2

affects expression

Omeprazole affects the expression of CADPS2 mRNA

NCBI chr 4:51,780,415...52,309,641
Ensembl chr 4:51,781,053...52,309,829

G

cell cycle associated protein 1

affects expression

Omeprazole affects the expression of CAPRIN1 mRNA

NCBI chr 3:90,152,305...90,230,447
Ensembl chr 3:90,153,620...90,230,502

G

carbonic anhydrase 2

affects expression

Omeprazole affects the expression of CA2 mRNA

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

carbonic anhydrase 3

affects expression

Omeprazole affects the expression of CAR3 mRNA

NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280

G

caspase 3

increases activity
multiple interactions
affects expression
increases cleavage

Omeprazole analog results in increased activity of CASP3 protein; Omeprazole results in increased activity of CASP3 protein
Omeprazole inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
Omeprazole inhibits the reaction [Ethanol results in increased activity of CASP3 protein]; Omeprazole inhibits the reaction [Ethanol results in increased expression of CASP3 mRNA]; Omeprazole inhibits the reaction [Indomethacin results in increased activity of CASP3 protein]
Omeprazole affects the expression of CASP3 mRNA
Omeprazole results in increased cleavage of CASP3 protein

PMID:15461867 PMID:18336733 PMID:19251492 PMID:19483382 PMID:25637687 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases cleavage

Omeprazole analog results in increased cleavage of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

catalase

increases activity
multiple interactions

Omeprazole results in increased activity of CAT protein
Omeprazole inhibits the reaction [Ethanol results in decreased activity of CAT protein]
Omeprazole inhibits the reaction [Acetic Acid results in increased activity of CAT protein]

PMID:18547560 PMID:28849987 PMID:33245926

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

carbonyl reductase 1

affects expression

Omeprazole affects the expression of CBR1 mRNA

NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393

G

cholecystokinin B receptor

multiple interactions

[Omeprazole co-treated with CCKBR protein] results in increased expression of IER3

NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881

G

cyclin D1

decreases expression

Omeprazole results in decreased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin-dependent kinase inhibitor 1A

increases expression

Omeprazole results in increased expression of CDKN1A protein

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cysteine dioxygenase type 1

affects expression

Omeprazole affects the expression of CDO1 mRNA

NCBI chr18:39,432,473...39,447,253
Ensembl chr18:39,432,474...39,447,296

G

choline/ethanolamine phosphotransferase 1

affects expression

Omeprazole affects the expression of CEPT1 mRNA

NCBI chr 2:193,994,220...194,036,141
Ensembl chr 2:193,993,447...194,035,578

G

carboxylesterase 2H

affects expression

Omeprazole affects the expression of CES2 mRNA

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

G

complement factor I

affects expression
decreases expression

Omeprazole affects the expression of CFI mRNA
Omeprazole results in decreased expression of CFI mRNA

PMID:19483382 PMID:25626140

NCBI chr 2:218,389,079...218,430,565
Ensembl chr 2:218,387,990...218,430,561

G

CF transmembrane conductance regulator

affects metabolic processing

CFTR protein affects the metabolism of Omeprazole

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

G

calcineurin-like EF-hand protein 1

affects expression

Omeprazole affects the expression of CHP1 mRNA

NCBI chr 3:106,536,009...106,571,255
Ensembl chr 3:106,536,004...106,571,251

G

CDGSH iron sulfur domain 1

affects expression

Omeprazole affects the expression of CISD1 mRNA

NCBI chr20:17,255,302...17,268,688
Ensembl chr20:17,255,151...17,284,924

G

chloride voltage-gated channel 4

affects expression

Omeprazole affects the expression of CLCN4 mRNA

NCBI chr X:23,729,194...23,795,391
Ensembl chr X:23,729,338...23,793,238

G

caseinolytic mitochondrial matrix peptidase proteolytic subunit

affects expression

Omeprazole affects the expression of CLPP mRNA

NCBI chr 9:1,831,680...1,837,700
Ensembl chr 9:1,830,311...1,837,693

G

CLPTM1-like

affects expression

Omeprazole affects the expression of CLPTM1L mRNA

NCBI chr 1:29,667,545...29,683,530
Ensembl chr 1:29,667,545...29,683,530

G

carboxymethylenebutenolidase homolog

affects expression

Omeprazole affects the expression of CMBL mRNA

NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009

G

cytidine/uridine monophosphate kinase 1

affects expression

Omeprazole affects the expression of CMPK1 mRNA

NCBI chr 5:128,480,301...128,507,830
Ensembl chr 5:128,480,301...128,507,830

G

COPI coat complex subunit gamma 1

affects expression

Omeprazole affects the expression of COPG1 mRNA

NCBI chr 4:120,366,540...120,392,502
Ensembl chr 4:120,366,542...120,415,616

G

COP9 signalosome subunit 4

affects expression

Omeprazole affects the expression of COPS4 mRNA

NCBI chr14:9,078,579...9,108,788
Ensembl chr14:9,078,576...9,108,887

G

coenzyme Q3 methyltransferase

affects expression

Omeprazole affects the expression of COQ3 mRNA

NCBI chr 5:35,429,567...35,460,613
Ensembl chr 5:35,429,574...35,460,607

G

cytochrome c oxidase subunit 4i1

affects expression

Omeprazole affects the expression of COX4I1 mRNA

NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921

G

carboxypeptidase N subunit 1

affects expression

Omeprazole affects the expression of CPN1 mRNA

NCBI chr 1:242,844,575...242,873,465
Ensembl chr 1:242,844,212...242,873,465

G

carboxypeptidase Q

affects expression

Omeprazole affects the expression of CPQ mRNA

NCBI chr 7:64,264,025...64,830,867
Ensembl chr 7:64,264,081...64,724,546

G

cAMP responsive element modulator

affects expression

Omeprazole affects the expression of CREM mRNA

NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989

G

casein kinase 2 beta

affects expression

Omeprazole affects the expression of CSNK2B mRNA

NCBI chr20:3,700,363...3,705,331
Ensembl chr20:3,698,733...3,707,133

G

cysteine and glycine-rich protein 1

affects expression

Omeprazole affects the expression of CSRP1 mRNA

NCBI chr13:47,158,171...47,179,388
Ensembl chr13:47,167,789...47,179,384

G

catenin alpha 1

affects expression

Omeprazole affects the expression of CTNNA1 mRNA

NCBI chr18:26,728,246...26,860,911
Ensembl chr18:26,728,485...26,860,910

G

cathepsin B

decreases activity

Omeprazole results in decreased activity of CTSB protein

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

cathepsin D

multiple interactions

Omeprazole inhibits the reaction [Cysteamine results in increased expression of CTSD protein]

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

cathepsin E

decreases expression

Omeprazole results in decreased expression of CTSE

NCBI chr13:43,091,954...43,114,509
Ensembl chr13:43,092,128...43,114,502

G

C-X-C motif chemokine receptor 4

decreases expression
multiple interactions

Omeprazole results in decreased expression of CXCR4 mRNA
AHR protein affects the reaction [Omeprazole results in decreased expression of CXCR4 mRNA]

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression
increases activity
decreases activity

AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein mutant form inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Omeprazole results in decreased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; Omeprazole promotes the reaction [AHR protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [ARNT protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [EP300 protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [NCOA1 protein binds to CYP1A1 promoter]
Omeprazole inhibits the reaction [Oxygen results in increased expression of CYP1A1 protein]; Omeprazole promotes the reaction [Oxygen results in decreased expression of CYP1A1 mRNA]
Omeprazole results in increased expression of CYP1A1 mRNA; Omeprazole results in increased expression of CYP1A1 protein
Omeprazole results in increased activity of CYP1A1 protein
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 mRNA; AHR protein promotes the reaction [Omeprazole results in increased expression of CYP1A1 protein]; daidzein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; daidzein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Genistein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; Genistein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; herbimycin inhibits the reaction [Omeprazole results in increased activity of CYP1A1 protein]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; lavendustin A inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Staurosporine inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Tosyllysine Chloromethyl Ketone inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]
Omeprazole results in decreased activity of CYP1A1 protein
Omeprazole results in increased activity of CYP1A1 promoter

PMID:8647108 PMID:8900397 PMID:9041675 PMID:9139728 PMID:9152597 More...

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity
multiple interactions
increases expression
increases activity

Omeprazole results in decreased activity of CYP1A2 protein
[Omeprazole results in increased expression of CYP1A2 protein] which results in decreased alkylation of Phenacetin; AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A2 mRNA]; Omeprazole results in increased expression of and results in increased activity of CYP1A2 protein
Omeprazole results in increased expression of CYP1A2 mRNA; Omeprazole results in increased expression of CYP1A2 protein
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A2 mRNA
Omeprazole results in increased activity of CYP1A2 promoter; Omeprazole results in increased activity of CYP1A2 protein

PMID:9152597 PMID:9744552 PMID:12040753 PMID:12623754 PMID:12841937 More...

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions
affects expression
increases expression
decreases activity

Omeprazole promotes the reaction [AHR protein binds to CYP1B1 promoter]; Omeprazole promotes the reaction [ARNT protein binds to CYP1B1 promoter]; Omeprazole promotes the reaction [EP300 protein binds to CYP1B1 promoter]; Omeprazole promotes the reaction [NCOA1 protein binds to CYP1B1 promoter]
Omeprazole affects the expression of CYP1B1 mRNA
Omeprazole results in increased expression of CYP1B1 mRNA
Omeprazole results in decreased activity of CYP1B1 protein

PMID:12040753 PMID:12623754 PMID:18420780 PMID:21703235 PMID:25826687

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily a, polypeptide 1

affects expression

Omeprazole affects the expression of CYP2A1 mRNA

NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887

G

cytochrome P450, family 2, subfamily b, polypeptide 1

increases expression

Omeprazole results in increased expression of CYP2B1 mRNA; Omeprazole results in increased expression of CYP2B1 protein

PMID:9152597 PMID:19118567

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 2

affects expression
increases expression

Omeprazole affects the expression of CYP2B2 mRNA
Omeprazole results in increased expression of CYP2B2 protein

PMID:9152597 PMID:19483382

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 2, subfamily b, polypeptide 3

affects expression
decreases activity
increases expression
increases activity

Omeprazole affects the expression of CYP2B3 mRNA
Omeprazole results in decreased activity of CYP2B10 protein
Omeprazole results in increased expression of CYP2B6 mRNA
Omeprazole results in increased activity of CYP2B6 protein

PMID:17954527 PMID:18420780 PMID:19118567 PMID:19483382 PMID:22524704

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily C, polypeptide 6

affects metabolic processing
decreases activity
multiple interactions
increases metabolic processing
decreases metabolic processing
increases hydroxylation

CYP2C19 protein affects the metabolism of Omeprazole
Omeprazole results in decreased activity of CYP2C19 protein
[5-bromotryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-chlorotryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-fluoro-alpha-methyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-fluorotryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-methyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [7-methyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [Chloramphenicol results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [Fluconazole results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [indopan results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [N,N-diisopropyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [Omeprazole results in decreased activity of CYP2C19 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine metabolite; [Omeprazole results in decreased activity of CYP2C19 protein] which results in decreased chemical synthesis of Aconitine metabolite; [Tryptamines analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; Omeprazole affects the reaction [CYP2C19 protein affects the metabolism of Warfarin]; Omeprazole inhibits the reaction [CYP2C19 protein results in decreased methylation of adinazolam]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased chemical synthesis of 4-hydroxymephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of auriculasin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of Fluoxetine]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased oxidation of 2-oxo-clopidogrel]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased oxidation of Clopidogrel]
CYP2C19 protein results in increased metabolism of Omeprazole
CYP2C19 gene alternative form results in decreased metabolism of Omeprazole
CYP2C19 protein results in increased hydroxylation of Omeprazole

PMID:8930576 PMID:9600717 PMID:11752104 PMID:12464242 PMID:12467917 More...

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily d, polypeptide 3

affects expression

Omeprazole affects the expression of CYP2D3 mRNA

NCBI chr 7:113,917,711...113,922,068
Ensembl chr 7:113,908,947...113,922,084

G

cytochrome P450, family 2, subfamily d, polypeptide 4

affects expression
decreases activity

Omeprazole affects the expression of CYP2D4 mRNA
Omeprazole results in decreased activity of CYP2D6 protein

PMID:18420780 PMID:19483382

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

Omeprazole results in increased expression of and results in increased activity of CYP2E1 protein

PMID:15802389 PMID:36243147

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 2, subfamily f, polypeptide 4

affects expression

Omeprazole affects the expression of CYP2F4 mRNA

NCBI chr 1:82,416,107...82,429,897
Ensembl chr 1:82,416,130...82,429,896

G

cytochrome P450, family 2, subfamily j, polypeptide 4

affects expression

Omeprazole affects the expression of CYP2J4 mRNA

NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794

G

cytochrome P450, family 2, subfamily t, polypeptide 1

affects expression

Omeprazole affects the expression of CYP2T1 mRNA

NCBI chr 1:82,446,321...82,451,564
Ensembl chr 1:82,446,921...82,451,563

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
increases expression
increases metabolic processing
affects metabolic processing

[Omeprazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; NR1I2 protein affects the reaction [Omeprazole results in increased expression of CYP3A4 mRNA]; Omeprazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Omeprazole results in increased expression of and results in increased activity of CYP3A4 protein
Omeprazole results in increased expression of CYP3A4 mRNA; Omeprazole results in increased expression of CYP3A4 protein
CYP3A4 protein results in increased metabolism of Omeprazole
CYP3A4 protein affects the metabolism of Omeprazole

PMID:7870052 PMID:8930576 PMID:9744552 PMID:12235278 PMID:12485723 More...

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

affects expression
increases expression

Omeprazole affects the expression of CYP3A23-3A1 mRNA
Omeprazole results in increased expression of CYP3A23-3A1 mRNA

PMID:19118567 PMID:19483382

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450, family 3, subfamily a, polypeptide 9

affects expression
increases expression

Omeprazole affects the expression of CYP3A9 mRNA
Omeprazole results in increased expression of CYP3A5 mRNA

PMID:19118567 PMID:19483382

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

cytochrome P450, family 4, subfamily a, polypeptide 8

affects expression

Omeprazole affects the expression of CYP4A8 mRNA

NCBI chr 5:128,702,130...128,733,476
Ensembl chr 5:128,702,131...128,733,476

G

cytochrome P450, family 4, subfamily f, polypeptide 6

affects expression

Omeprazole affects the expression of CYP4F6 mRNA

NCBI chr 7:12,030,276...12,058,020
Ensembl chr 7:12,030,301...12,057,782

G

diazepam binding inhibitor

affects expression

Omeprazole affects the expression of DBI mRNA

NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693

G

DDB1 and CUL4 associated factor 11

affects expression

Omeprazole affects the expression of DCAF11 mRNA

NCBI chr15:29,046,744...29,057,450
Ensembl chr15:29,046,826...29,057,669

G

dicarbonyl and L-xylulose reductase

affects expression

Omeprazole affects the expression of DCXR mRNA

NCBI chr10:106,006,404...106,008,293

G

DNA-damage inducible transcript 3

increases expression

Omeprazole results in increased expression of DDIT3 protein

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

2,4-dienoyl-CoA reductase 1

affects expression

Omeprazole affects the expression of DECR1 mRNA

NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018

G

Dexi homolog

affects expression

Omeprazole affects the expression of DEXI mRNA

NCBI chr10:5,126,021...5,138,746
Ensembl chr10:5,137,288...5,138,738

G

diacylglycerol O-acyltransferase 1

affects expression

Omeprazole affects the expression of DGAT1 mRNA

NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299

G

24-dehydrocholesterol reductase

affects expression

Omeprazole affects the expression of DHCR24 mRNA

NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137

G

dehydrogenase/reductase 4

affects expression

Omeprazole affects the expression of DHRS4 mRNA

NCBI chr15:28,966,544...28,978,135
Ensembl chr15:28,966,553...28,978,127

G

dehydrogenase/reductase 7B

affects expression

Omeprazole affects the expression of DHRS7B mRNA

NCBI chr10:45,504,344...45,537,094
Ensembl chr10:45,504,426...45,537,076

G

DEAH-box helicase 16

affects expression

Omeprazole affects the expression of DHX16 mRNA

NCBI chr20:2,862,000...2,874,991
Ensembl chr20:2,862,000...2,874,948

G

distal membrane arm assembly component 2 like

affects expression

Omeprazole affects the expression of DMAC2L mRNA

NCBI chr 6:88,205,580...88,223,934
Ensembl chr 6:88,205,700...88,223,933

G

DnaJ heat shock protein family (Hsp40) member C3

affects expression

Omeprazole affects the expression of DNAJC3 mRNA

NCBI chr15:96,025,605...96,068,585
Ensembl chr15:96,025,624...96,065,181

G

dipeptidylpeptidase 4

affects expression

Omeprazole affects the expression of DPP4 mRNA

NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901

G

dihydropyrimidine dehydrogenase

affects expression

Omeprazole affects the expression of DPYD mRNA

NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982

G

glutamyl-tRNA synthetase 2, mitochondrial

affects expression

Omeprazole affects the expression of EARS2 mRNA

NCBI chr 1:176,597,986...176,625,848
Ensembl chr 1:176,597,986...176,625,836

G

enoyl-CoA hydratase, short chain 1

affects expression

Omeprazole affects the expression of ECHS1 mRNA

NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884

G

enoyl-CoA delta isomerase 1

affects expression

Omeprazole affects the expression of ECI1 mRNA

NCBI chr10:13,456,715...13,470,061
Ensembl chr10:13,456,563...13,470,061

G

enoyl-CoA delta isomerase 2

affects expression

Omeprazole affects the expression of ECI2 mRNA

NCBI chr17:29,850,884...29,886,781
Ensembl chr17:29,870,391...29,886,781

G

eukaryotic translation elongation factor 1 gamma

affects expression

Omeprazole affects the expression of EEF1G mRNA

NCBI chr 1:205,860,713...205,871,319
Ensembl chr 1:205,860,698...205,872,382

G

epidermal growth factor

multiple interactions

Omeprazole promotes the reaction [Indomethacin results in increased expression of EGF protein]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

affects expression

Omeprazole affects the expression of EHHADH mRNA

NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188

G

eukaryotic translation initiation factor 4A2

affects expression

Omeprazole affects the expression of EIF4A2 mRNA

NCBI chr11:77,764,126...77,770,810
Ensembl chr11:77,764,124...77,770,781

G

eukaryotic translation initiation factor 4E binding protein 1

affects expression

Omeprazole affects the expression of EIF4EBP1 mRNA

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

eukaryotic translation initiation factor 4H

affects expression

Omeprazole affects the expression of EIF4H mRNA

NCBI chr12:22,083,155...22,099,876
Ensembl chr12:22,082,835...22,099,876

G

ectodermal-neural cortex 1

affects expression

Omeprazole affects the expression of ENC1 mRNA

NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713

G

enolase 1

affects expression

Omeprazole affects the expression of ENO1 mRNA

NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336

G

glutamyl aminopeptidase

affects expression

Omeprazole affects the expression of ENPEP mRNA

NCBI chr 2:217,781,985...217,851,947
Ensembl chr 2:217,782,005...217,851,947

G

ectonucleotide pyrophosphatase/phosphodiesterase 1

affects expression

Omeprazole affects the expression of ENPP1 mRNA

NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715

G

E1A binding protein p300

multiple interactions

Omeprazole promotes the reaction [EP300 protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [EP300 protein binds to CYP1B1 promoter]

NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088

G

epithelial cell adhesion molecule

affects expression

Omeprazole affects the expression of EPCAM mRNA

NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127

G

endoplasmic reticulum protein 29

affects expression

Omeprazole affects the expression of ERP29 mRNA

NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376

G

esterase D

affects expression

Omeprazole affects the expression of ESD mRNA

NCBI chr15:50,043,634...50,063,134
Ensembl chr15:50,043,632...50,063,144

G

electron transfer flavoprotein subunit beta

affects expression

Omeprazole affects the expression of ETFB mRNA

NCBI chr 1:93,851,908...93,866,072
Ensembl chr 1:93,851,858...93,866,068

G

fatty acid amide hydrolase

affects expression

Omeprazole affects the expression of FAAH mRNA

NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677

G

fatty acid desaturase 2

affects expression

Omeprazole affects the expression of FADS2 mRNA

NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789

G

fructose-bisphosphatase 1

affects expression

Omeprazole affects the expression of FBP1 mRNA

NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071

G

farnesyl diphosphate farnesyl transferase 1

affects expression

Omeprazole affects the expression of FDFT1 mRNA

NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287

G

farnesyl diphosphate synthase

affects expression

Omeprazole affects the expression of FDPS mRNA

NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776

G

ferredoxin 2

affects expression

Omeprazole affects the expression of FDX2 mRNA

NCBI chr 8:19,604,916...19,609,832
Ensembl chr 8:19,604,916...19,609,849

G

flavin containing dimethylaniline monoxygenase 1

affects expression

Omeprazole affects the expression of FMO1 mRNA

NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647

G

guanidinoacetate N-methyltransferase

affects expression

Omeprazole affects the expression of GAMT mRNA

NCBI chr 7:9,448,590...9,451,413
Ensembl chr 7:9,448,628...9,451,778

G

glyceraldehyde-3-phosphate dehydrogenase

affects expression

Omeprazole affects the expression of GAPDH mRNA

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

gastrin

increases expression

Omeprazole results in increased expression of GAST protein

PMID:11422300 PMID:12189558 PMID:12763636 PMID:15223672 PMID:16618411 More...

NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496

G

1,4-alpha-glucan branching enzyme 1

affects expression

Omeprazole affects the expression of GBE1 mRNA

NCBI chr11:8,734,806...9,000,226
Ensembl chr11:8,734,820...9,000,210

G

GTP cyclohydrolase I feedback regulator

affects expression

Omeprazole affects the expression of GCHFR mRNA

NCBI chr 3:106,158,046...106,162,080
Ensembl chr 3:106,159,394...106,162,080

G

gamma-glutamyl hydrolase

affects expression

Omeprazole affects the expression of GGH mRNA

NCBI chr 5:33,529,880...33,552,790
Ensembl chr 5:33,529,880...33,552,787

G

gamma-glutamyltransferase 1

multiple interactions

[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GGT1 mRNA

NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442

G

gap junction protein, beta 1

affects expression

Omeprazole affects the expression of GJB1 mRNA

NCBI chr X:66,501,848...66,509,783
Ensembl chr X:66,501,820...66,509,925

G

glycosylphosphatidylinositol specific phospholipase D1

affects expression

Omeprazole affects the expression of GPLD1 mRNA

NCBI chr17:40,084,427...40,132,035
Ensembl chr17:40,084,617...40,126,939

G

glutathione peroxidase 1

affects expression

Omeprazole affects the expression of GPX1 mRNA

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 2

multiple interactions

[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA

NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877

G

glutathione peroxidase 4

affects expression

Omeprazole affects the expression of GPX4 mRNA

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

glutamate ionotropic receptor NMDA type subunit associated protein 1

affects expression

Omeprazole affects the expression of GRINA mRNA

NCBI chr 7:107,962,194...107,965,372
Ensembl chr 7:107,962,207...107,965,366

G

GrpE-like 1, mitochondrial

affects expression

Omeprazole affects the expression of GRPEL1 mRNA

NCBI chr14:74,292,023...74,298,243
Ensembl chr14:74,292,023...74,298,200

G

glutathione S-transferase alpha 5

multiple interactions
increases expression

[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA
Omeprazole results in increased expression of GSTA5 mRNA

PMID:17202759 PMID:22687989

NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472

G

glutathione S-transferase pi 1

increases expression

Omeprazole results in increased expression of GSTP1 mRNA

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

glutathione S-transferase theta 1

affects expression

Omeprazole affects the expression of GSTT1 mRNA

NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585

G

general transcription factor IIH subunit 5

affects expression

Omeprazole affects the expression of GTF2H5 mRNA

NCBI chr 1:46,656,804...46,663,512
Ensembl chr 1:46,656,859...46,664,939

G

granzyme A

affects expression

Omeprazole affects the expression of GZMA mRNA

NCBI chr 2:44,740,569...44,752,502
Ensembl chr 2:44,740,569...44,752,493

G

H3.3 histone B

affects expression

Omeprazole affects the expression of H3F3B mRNA

NCBI chr10:101,256,484...101,258,716
Ensembl chr10:101,256,480...101,258,709
Ensembl chr13:101,256,480...101,258,709

G

histidine ammonia lyase

affects expression

Omeprazole affects the expression of HAL mRNA

NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701

G

hepcidin antimicrobial peptide

increases secretion
multiple interactions
increases expression

Omeprazole results in increased secretion of HAMP protein
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Omeprazole results in increased expression of HAMP mRNA]; AHR protein affects the reaction [Omeprazole results in increased expression of HAMP mRNA]
Omeprazole results in increased expression of HAMP mRNA; Omeprazole results in increased expression of HAMP protein

NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891

G

hydroxyacid oxidase 2

affects expression

Omeprazole affects the expression of HAO2 mRNA

NCBI chr 2:186,200,137...186,232,997
Ensembl chr 2:186,200,504...186,224,425

G

hemoglobin alpha, adult chain 2

affects expression

Omeprazole affects the expression of HBA-A2 mRNA

NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392
Ensembl chr10:15,307,815...15,338,392

G

hemoglobin subunit beta

affects expression

Omeprazole affects the expression of HBB mRNA

NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012

G

histidine decarboxylase

affects expression
increases expression
increases stability
multiple interactions

Omeprazole affects the expression of HDC mRNA
Omeprazole results in increased expression of HDC mRNA
Omeprazole results in increased stability of HDC protein
Omeprazole results in increased expression of and results in increased activity of HDC protein

PMID:12763636 PMID:19483382

NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341

G

homogentisate 1, 2-dioxygenase

affects expression

Omeprazole affects the expression of HGD mRNA

NCBI chr11:63,086,750...63,138,325
Ensembl chr11:63,086,752...63,138,323

G

high mobility group nucleosome binding domain 1

affects expression

Omeprazole affects the expression of HMGN1 mRNA

NCBI chr11:35,422,328...35,428,247
Ensembl chr11:35,422,328...35,428,254

G

heme oxygenase 1

increases expression
multiple interactions

Omeprazole results in increased expression of HMOX1 mRNA; Omeprazole results in increased expression of HMOX1 protein
Acetylcysteine promotes the reaction [Omeprazole results in increased expression of HMOX1 mRNA]; Acetylcysteine promotes the reaction [Omeprazole results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 protein]; Omeprazole results in increased expression of and results in increased activity of HMOX1 protein

PMID:16712795 PMID:27725188

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hypoxanthine phosphoribosyltransferase 1

affects expression

Omeprazole affects the expression of HPRT1 mRNA

NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154

G

HPS5, biogenesis of lysosomal organelles complex 2 subunit 2

affects expression

Omeprazole affects the expression of HPS5 mRNA

NCBI chr 1:97,281,626...97,320,945
Ensembl chr 1:97,247,598...97,321,019

G

hydroxysteroid (17-beta) dehydrogenase 4

affects expression

Omeprazole affects the expression of HSD17B4 mRNA

NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952

G

hydroxysteroid dehydrogenase like 2

affects expression

Omeprazole affects the expression of HSDL2 mRNA

NCBI chr 5:74,443,933...74,479,104
Ensembl chr 5:74,443,872...74,479,839

G

heat shock protein family A (Hsp70) member 1A

multiple interactions
decreases expression

Zinc Compounds analog inhibits the reaction [Omeprazole results in decreased expression of HSPA1A protein]; Zinc Sulfate inhibits the reaction [Omeprazole results in decreased expression of HSPA1A protein]
Omeprazole results in decreased expression of HSPA1A mRNA; Omeprazole results in decreased expression of HSPA1A protein

PMID:15223672 PMID:16945336

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 1 like

multiple interactions

Omeprazole inhibits the reaction [Ethanol results in increased expression of HSPA1L mRNA]

NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571

G

HtrA serine peptidase 1

affects expression

Omeprazole affects the expression of HTRA1 mRNA

NCBI chr 1:185,497,815...185,547,380
Ensembl chr 1:185,497,735...185,547,379

G

immediate early response 3

multiple interactions

[Omeprazole co-treated with CCKBR protein] results in increased expression of IER3

NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583

G

interferon gamma

multiple interactions

Omeprazole inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 1

affects expression

Omeprazole affects the expression of IGF1 mRNA

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor binding protein, acid labile subunit

affects expression

Omeprazole affects the expression of IGFALS mRNA

NCBI chr10:13,897,468...13,903,920
Ensembl chr10:13,898,395...13,902,677

G

insulin-like growth factor binding protein 2

affects expression

Omeprazole affects the expression of IGFBP2 mRNA

NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937

G

interleukin 10

multiple interactions

Omeprazole inhibits the reaction [Ethanol results in decreased expression of IL10 protein]

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

multiple interactions

Omeprazole inhibits the reaction [Cisplatin results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

Omeprazole inhibits the reaction [Cisplatin results in increased expression of IL6 protein]; Omeprazole inhibits the reaction [Ethanol results in decreased expression of IL6 protein]

PMID:25637687 PMID:32418911

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

inositol monophosphatase 1

affects expression

Omeprazole affects the expression of IMPA1 mRNA

NCBI chr 2:91,462,781...91,484,057
Ensembl chr 2:91,462,799...91,484,313

G

inhibin subunit beta E

affects expression

Omeprazole affects the expression of INHBE mRNA

NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172

G

inositol-3-phosphate synthase 1

affects expression

Omeprazole affects the expression of ISYNA1 mRNA

NCBI chr16:18,839,143...18,841,979
Ensembl chr16:18,839,145...18,841,979

G

inter-alpha-trypsin inhibitor heavy chain 4

affects expression

Omeprazole affects the expression of ITIH4 mRNA

NCBI chr16:6,080,539...6,095,710
Ensembl chr16:6,080,539...6,095,708

G

Janus kinase 1

affects expression

Omeprazole affects the expression of JAK1 mRNA

NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926

G

KDEL endoplasmic reticulum protein retention receptor 2

affects expression

Omeprazole affects the expression of KDELR2 mRNA

NCBI chr12:11,138,820...11,157,117
Ensembl chr12:11,138,820...11,157,153

G

kinase insert domain receptor

affects expression
multiple interactions

Omeprazole affects the expression of KDR mRNA
Omeprazole promotes the reaction [Oxygen results in decreased expression of KDR protein]

PMID:19483382 PMID:26272953

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

keratin 8

affects expression

Omeprazole affects the expression of KRT8 mRNA

NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728

G

lecithin cholesterol acyltransferase

affects expression

Omeprazole affects the expression of LCAT mRNA

NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231

G

leucine carboxyl methyltransferase 1

affects expression

Omeprazole affects the expression of LCMT1 mRNA

NCBI chr 1:177,904,119...177,960,111
Ensembl chr 1:177,904,139...177,960,112

G

lipase C, hepatic type

affects expression

Omeprazole affects the expression of LIPC mRNA

NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464

G

lysyl oxidase

affects expression

Omeprazole affects the expression of LOX mRNA

NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477

G

LDL receptor related protein 3

affects expression

Omeprazole affects the expression of LRP3 mRNA

NCBI chr 1:87,843,815...87,859,147
Ensembl chr 1:87,844,868...87,859,110

G

mannosidase, alpha, class 2B, member 1

affects expression

Omeprazole affects the expression of MAN2B1 mRNA

NCBI chr19:23,055,092...23,074,398
Ensembl chr19:23,055,097...23,074,389

G

mitogen activated protein kinase kinase 2

affects expression

Omeprazole affects the expression of MAP2K2 mRNA

NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243

G

mitogen activated protein kinase 14

multiple interactions

Omeprazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK14 protein]

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

MBL associated serine protease 2

affects expression

Omeprazole affects the expression of MASP2 mRNA

NCBI chr 5:159,035,892...159,049,561
Ensembl chr 5:159,035,911...159,049,580

G

malic enzyme 1

affects expression
multiple interactions

Omeprazole affects the expression of ME1 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of ME1 mRNA

PMID:19483382 PMID:22687989

NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304

G

matrix metallopeptidase 14

multiple interactions

Omeprazole inhibits the reaction [Indomethacin results in decreased expression of MMP14 protein]

NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864

G

matrix metallopeptidase 2

multiple interactions

Omeprazole inhibits the reaction [Hydrogen Peroxide results in decreased activity of MMP2 protein]

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

methylmalonyl-CoA mutase

affects expression

Omeprazole affects the expression of MMUT mRNA

NCBI chr 9:19,928,720...19,956,985
Ensembl chr 9:19,928,727...19,957,046

G

myeloperoxidase

multiple interactions
decreases activity

Omeprazole inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; Omeprazole inhibits the reaction [Acids results in increased activity of MPO protein]
Omeprazole results in decreased activity of MPO protein
Omeprazole inhibits the reaction [Acetic Acid results in increased activity of MPO protein]; Omeprazole inhibits the reaction [Cysteamine results in increased expression of MPO protein]; Omeprazole inhibits the reaction [Ethanol results in increased activity of MPO protein]; Omeprazole inhibits the reaction [Indomethacin results in increased activity of MPO protein]

PMID:16091555 PMID:17151854 PMID:20165931 PMID:25637687 PMID:27780710 More...

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

maestro

affects expression

Omeprazole affects the expression of MRO mRNA

NCBI chr18:67,450,186...67,467,593
Ensembl chr18:67,450,595...67,467,044

G

mitochondrial ribosomal protein L2

affects expression

Omeprazole affects the expression of MRPL2 mRNA

NCBI chr 9:14,333,233...14,337,006
Ensembl chr 9:14,333,234...14,337,040

G

mitochondrial ribosomal protein L9

affects expression

Omeprazole affects the expression of MRPL9 mRNA

NCBI chr 2:182,082,012...182,086,758
Ensembl chr 2:182,076,369...182,087,095

G

murinoglobulin 2

affects expression

Omeprazole affects the expression of PZP mRNA

NCBI chr 4:155,164,061...155,236,894
Ensembl chr 4:155,164,011...155,236,475

G

myeloid-associated differentiation marker

affects expression

Omeprazole affects the expression of MYADM mRNA

NCBI chr 1:65,864,180...65,874,701
Ensembl chr 1:65,864,173...65,874,035

G

MYC binding protein 2

affects expression

Omeprazole affects the expression of MYCBP2 mRNA

NCBI chr15:79,937,354...80,175,432
Ensembl chr15:79,937,354...80,175,498

G

myosin ID

affects expression

Omeprazole affects the expression of MYO1D mRNA

NCBI chr10:65,489,153...65,765,812
Ensembl chr10:65,489,154...65,766,349

G

N(alpha)-acetyltransferase 38, NatC auxiliary subunit

affects expression

Omeprazole affects the expression of NAA38 mRNA

NCBI chr10:54,117,754...54,118,913
Ensembl chr10:54,117,163...54,119,494

G

nucleosome assembly protein 1-like 1

affects expression

Omeprazole affects the expression of NAP1L1 mRNA

NCBI chr 7:46,933,278...46,957,853
Ensembl chr 7:46,933,356...46,956,593

G

N-acetyltransferase 8

affects expression

Omeprazole affects the expression of NAT8 mRNA

NCBI chr 4:118,279,521...118,284,671
Ensembl chr 4:118,270,954...118,281,763

G

nuclear receptor coactivator 1

multiple interactions

Omeprazole promotes the reaction [NCOA1 protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [NCOA1 protein binds to CYP1B1 promoter]

NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664

G

NDRG family member 2

affects expression

Omeprazole affects the expression of NDRG2 mRNA

NCBI chr15:24,600,981...24,609,621
Ensembl chr15:24,600,982...24,609,626

G

NADH:ubiquinone oxidoreductase subunit S5

affects expression

Omeprazole affects the expression of NDUFS5 mRNA

NCBI chr 5:135,974,029...135,979,705
Ensembl chr 5:135,974,034...135,979,603
Ensembl chr14:135,974,034...135,979,603
Ensembl chr 2:135,974,034...135,979,603

G

NADH:ubiquinone oxidoreductase subunit V3

affects expression

Omeprazole affects the expression of NDUFV3 mRNA

NCBI chr20:9,612,462...9,621,622
Ensembl chr20:9,612,431...9,623,074
Ensembl chr13:9,612,431...9,623,074

G

neuraminidase 2

affects expression

Omeprazole affects the expression of NEU2 mRNA

NCBI chr 9:88,218,494...88,267,356
Ensembl chr 9:88,249,135...88,267,355

G

NFE2 like bZIP transcription factor 2

multiple interactions

NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 protein]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

multiple interactions

Omeprazole inhibits the reaction [Cisplatin results in decreased expression of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nuclear transcription factor, X-box binding 1

affects expression

Omeprazole affects the expression of NFX1 mRNA

NCBI chr 5:56,104,945...56,162,912
Ensembl chr 5:56,105,234...56,162,912

G

NIPA-like domain containing 2

affects expression

Omeprazole affects the expression of NIPAL2 mRNA

NCBI chr 7:65,774,477...65,884,807
Ensembl chr 7:65,774,477...65,884,807

G

nitrilase 1

affects expression

Omeprazole affects the expression of NIT1 mRNA

NCBI chr13:83,769,888...83,773,324
Ensembl chr13:83,765,941...83,773,332

G

NLR family, pyrin domain containing 3

multiple interactions

Lipopolysaccharides inhibits the reaction [Omeprazole inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]]; Omeprazole inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

NME/NM23 nucleoside diphosphate kinase 2

affects expression

Omeprazole affects the expression of NME2 mRNA

NCBI chr10:78,898,097...78,903,514
Ensembl chr10:78,897,770...78,903,538
Ensembl chr20:78,897,770...78,903,538

G

NAD(P)H quinone dehydrogenase 1

increases expression
multiple interactions

Omeprazole results in increased expression of NQO1 mRNA
Omeprazole inhibits the reaction [Oxygen results in increased expression of NQO1 mRNA]; Omeprazole inhibits the reaction [Oxygen results in increased expression of NQO1 protein]
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of NQO1 mRNA

PMID:17202759 PMID:22687989 PMID:26272953

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
increases activity

[Omeprazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; NR1I2 protein affects the reaction [Omeprazole results in increased expression of CYP3A4 mRNA]

PMID:12695340 PMID:17041008 PMID:25680588 PMID:26187274 PMID:27732639

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

affects expression
decreases metabolic processing
increases expression

Omeprazole affects the expression of NR1I3 mRNA
NR1I3 gene mutant form results in decreased metabolism of Omeprazole
Omeprazole results in increased expression of NR1I3 mRNA

PMID:19118567 PMID:19483382 PMID:27434302

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

nuclear receptor subfamily 3, group C, member 1

affects expression

Omeprazole affects the expression of NR3C1 mRNA

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

out at first homolog

affects expression

Omeprazole affects the expression of OAF mRNA

NCBI chr 8:43,594,362...43,612,334
Ensembl chr 8:43,594,363...43,612,334

G

alpha-2u globulin PGCL4

affects expression

Omeprazole affects the expression of OBP3 mRNA

NCBI chr 5:74,842,316...74,845,858
Ensembl chr 5:74,842,316...74,845,757

G

oxoglutarate dehydrogenase

affects expression

Omeprazole affects the expression of OGDH mRNA

NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479

G

olfactory receptor 59

affects expression

Omeprazole affects the expression of OLR59 mRNA

NCBI chr 1:157,193,051...157,227,707
Ensembl chr 1:157,193,080...157,211,179

G

oligosaccharyltransferase complex non-catalytic subunit

affects expression

Omeprazole affects the expression of OSTC mRNA

NCBI chr 2:219,250,549...219,266,076
Ensembl chr 2:219,236,952...219,266,107

G

ornithine transcarbamylase

affects expression

Omeprazole affects the expression of OTC mRNA

NCBI chr X:12,453,834...12,529,954
Ensembl chr X:12,453,834...12,566,918

G

poly(A) binding protein, cytoplasmic 4

affects expression

Omeprazole affects the expression of PABPC4 mRNA

NCBI chr 5:135,563,142...135,578,985
Ensembl chr 5:135,563,562...135,578,979

G

phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase

affects expression

Omeprazole affects the expression of PAICS mRNA

NCBI chr14:31,199,086...31,232,731
Ensembl chr14:31,173,541...31,232,635

G

poly (ADP-ribose) polymerase 1

increases cleavage

Omeprazole results in increased cleavage of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

pyruvate carboxylase

affects expression

Omeprazole affects the expression of PCX mRNA

NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380

G

propionyl-CoA carboxylase subunit beta

affects expression

Omeprazole affects the expression of PCCB mRNA

NCBI chr 8:101,591,218...101,641,213
Ensembl chr 8:101,590,737...101,641,234

G

proliferating cell nuclear antigen

multiple interactions

[Omeprazole co-treated with Indomethacin] promotes the reaction [Acetic Acid results in increased expression of PCNA protein]; Omeprazole promotes the reaction [Acetic Acid results in increased expression of PCNA protein]
Omeprazole inhibits the reaction [Ethanol results in decreased expression of PCNA protein]

PMID:19251492 PMID:26970604

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

proprotein convertase subtilisin/kexin type 6

affects expression

Omeprazole affects the expression of PCSK6 mRNA

NCBI chr 1:119,428,978...119,627,626
Ensembl chr 1:119,429,265...119,627,596

G

phosphatidylcholine transfer protein

affects expression

Omeprazole affects the expression of PCTP mRNA

NCBI chr10:74,808,887...74,856,260
Ensembl chr10:74,808,887...74,849,867

G

phosducin-like 3

affects expression

Omeprazole affects the expression of PDCL3 mRNA

NCBI chr 9:41,234,322...41,243,769
Ensembl chr 9:41,234,234...41,243,735

G

protein disulfide isomerase family A, member 3

affects expression

Omeprazole affects the expression of PDIA3 mRNA

NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236

G

protein disulfide isomerase family A, member 6

affects expression

Omeprazole affects the expression of PDIA6 mRNA

NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:40,062,926...40,080,613

G

peroxisomal biogenesis factor 19

affects expression

Omeprazole affects the expression of PEX19 mRNA

NCBI chr13:84,592,277...84,608,793
Ensembl chr13:84,592,312...84,608,608

G

phosphoglycerate mutase 1

affects expression

Omeprazole affects the expression of PGAM1 mRNA

NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452

G

progesterone receptor membrane component 1

affects expression

Omeprazole affects the expression of PGRMC1 mRNA

NCBI chr X:115,832,865...115,841,060
Ensembl chr X:115,832,884...115,888,682

G

phytanoyl-CoA 2-hydroxylase

affects expression

Omeprazole affects the expression of PHYH mRNA

NCBI chr17:73,329,461...73,346,359
Ensembl chr17:73,329,082...73,346,409

G

phosphatidylinositol glycan anchor biosynthesis, class P

affects expression

Omeprazole affects the expression of PIGP mRNA

NCBI chr11:33,682,943...33,689,111
Ensembl chr11:33,682,948...33,689,321

G

pyruvate kinase L/R

affects expression

Omeprazole affects the expression of PKLR mRNA

NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870

G

phospholipase A2 group 4A

increases phosphorylation
multiple interactions

Omeprazole results in increased phosphorylation of PLA2G4A protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Omeprazole results in increased phosphorylation of PLA2G4A protein]

NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266

G

phospholipase B domain containing 1

affects expression

Omeprazole affects the expression of PLBD1 mRNA

NCBI chr 4:169,472,983...169,529,277
Ensembl chr 4:169,472,983...169,529,277

G

plasminogen

affects expression

Omeprazole affects the expression of PLG mRNA

NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786

G

plastin 3

affects expression

Omeprazole affects the expression of PLS3 mRNA

NCBI chr X:111,589,193...111,683,908
Ensembl chr X:111,589,254...111,683,891

G

paraoxonase 2

affects expression

Omeprazole affects the expression of PON2 mRNA

NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248

G

POU class 2 homeobox 2

multiple interactions

Omeprazole inhibits the reaction [Cisplatin results in increased expression of POU2F2 protein]

NCBI chr 1:80,682,330...80,769,756
Ensembl chr 1:80,685,741...80,724,261

G

pancreatic progenitor cell differentiation and proliferation factor

affects expression

Omeprazole affects the expression of PPDPF mRNA

NCBI chr 3:168,299,309...168,301,040
Ensembl chr 3:168,299,791...168,301,036

G

peroxiredoxin 2

affects expression

Omeprazole affects the expression of PRDX2 mRNA

NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194

G

peroxiredoxin 6

affects expression

Omeprazole affects the expression of PRDX6 mRNA

NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355

G

prolactin

increases expression

Omeprazole results in increased expression of PRL protein

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

protein C, inactivator of coagulation factors Va and VIIIa

affects expression

Omeprazole affects the expression of PROC mRNA

NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133

G

phosphoribosyl pyrophosphate synthetase-associated protein 1

affects expression

Omeprazole affects the expression of PRPSAP1 mRNA

NCBI chr10:101,701,094...101,750,753
Ensembl chr10:101,701,096...101,750,751

G

proteasome 20S subunit alpha 6

affects expression

Omeprazole affects the expression of PSMA6 mRNA

NCBI chr 6:72,765,534...72,796,554
Ensembl chr 6:72,765,473...72,796,554

G

proteasome 20S subunit beta 1

affects expression

Omeprazole affects the expression of PSMB1 mRNA

NCBI chr 1:56,442,432...56,463,544
Ensembl chr 1:56,420,618...56,463,560

G

proteasome 20S subunit beta 3

affects expression

Omeprazole affects the expression of PSMB3 mRNA

NCBI chr10:82,697,425...82,704,521
Ensembl chr10:82,697,425...82,704,521

G

proteasome 26S subunit, ATPase 1

affects expression

Omeprazole affects the expression of PSMC1 mRNA

NCBI chr 6:119,392,833...119,405,233
Ensembl chr 6:119,392,855...119,410,123

G

proteasome 26S subunit, ATPase 3

affects expression

Omeprazole affects the expression of PSMC3 mRNA

NCBI chr 3:77,031,825...77,037,207
Ensembl chr 3:77,031,825...77,043,358

G

proteasome 26S subunit, ATPase 5

affects expression

Omeprazole affects the expression of PSMC5 mRNA

NCBI chr10:91,187,763...91,193,697
Ensembl chr10:91,187,743...91,213,135

G

proteasome 26S subunit, non-ATPase 1

affects expression

Omeprazole affects the expression of PSMD1 mRNA

NCBI chr 9:86,709,714...86,785,213
Ensembl chr 9:86,709,947...86,785,211

G

proteasome 26S subunit ubiquitin receptor, non-ATPase 4

affects expression

Omeprazole affects the expression of PSMD4 mRNA

NCBI chr 2:182,598,934...182,608,250
Ensembl chr 2:182,598,934...182,608,194

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[Omeprazole co-treated with beta-Naphthoflavone] results in increased expression of PTGS2 mRNA; [Omeprazole co-treated with beta-Naphthoflavone] results in increased expression of PTGS2 protein
Omeprazole inhibits the reaction [Ethanol results in increased expression of PTGS2 protein]

PMID:23038005 PMID:26970604

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

parathymosin

affects expression

Omeprazole affects the expression of PTMS mRNA

NCBI chr 4:157,722,384...157,726,575
Ensembl chr 4:157,722,386...157,727,009

G

protein tyrosine phosphatase, receptor type, F

affects expression

Omeprazole affects the expression of PTPRF mRNA

NCBI chr 5:131,741,959...131,824,000
Ensembl chr 5:131,742,754...131,810,023

G

PTTG1 interacting protein

affects expression

Omeprazole affects the expression of PTTG1IP mRNA

NCBI chr20:11,030,013...11,047,742
Ensembl chr20:11,030,015...11,047,316

G

glycogen phosphorylase L

affects expression

Omeprazole affects the expression of PYGL mRNA

NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310

G

RAB5 interacting factor

affects expression

Omeprazole affects the expression of RAB5IF mRNA

NCBI chr 3:145,357,990...145,368,012
Ensembl chr 3:145,357,861...145,368,012

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

[Omeprazole co-treated with Indomethacin] promotes the reaction [Acetic Acid results in increased expression of RELA protein]; Lipopolysaccharides inhibits the reaction [Omeprazole inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]]; Omeprazole inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]
Omeprazole inhibits the reaction [Cisplatin affects the localization of RELA protein]

PMID:19251492 PMID:30452898 PMID:32418911

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

retinol saturase

increases expression

Omeprazole results in increased expression of RETSAT mRNA

NCBI chr 4:104,653,306...104,662,069
Ensembl chr 4:104,653,155...104,668,310

G

reactive intermediate imine deaminase A homolog

affects expression

Omeprazole affects the expression of RIDA mRNA

NCBI chr 7:65,691,429...65,705,257
Ensembl chr 7:65,691,435...65,705,716

G

ribonuclease A family member 4

affects expression

Omeprazole affects the expression of RNASE4 mRNA

NCBI chr15:24,312,765...24,330,112
Ensembl chr15:24,312,464...24,330,117

G

ring finger protein 103

affects expression

Omeprazole affects the expression of RNF103 mRNA

NCBI chr 4:103,526,456...103,542,529
Ensembl chr 4:103,526,502...103,555,919

G

RNA binding protein with serine rich domain 1

affects expression

Omeprazole affects the expression of RNPS1 mRNA

NCBI chr10:13,445,516...13,455,858
Ensembl chr10:13,445,653...13,455,858

G

ribosomal protein L11

affects expression

Omeprazole affects the expression of RPL11 mRNA

NCBI chr 5:148,274,060...148,277,708
Ensembl chr 5:148,274,069...148,277,599

G

ribosomal protein L13

affects expression

Omeprazole affects the expression of RPL13 mRNA

NCBI chr19:51,153,990...51,156,541
Ensembl chr19:51,153,924...51,163,014

G

ribosomal protein L15

affects expression

Omeprazole affects the expression of RPL15 mRNA

NCBI chr15:7,503,883...7,507,166
Ensembl chr15:7,503,883...7,507,165
Ensembl chr12:7,503,883...7,507,165

G

ribosomal protein L17

affects expression

Omeprazole affects the expression of RPL17 mRNA

NCBI chr18:68,581,141...68,584,253
Ensembl chr18:68,581,098...68,584,253
Ensembl chr 3:68,581,098...68,584,253

G

ribosomal protein L23

affects expression

Omeprazole affects the expression of RPL23 mRNA

NCBI chr10:82,771,878...82,775,840
Ensembl chr10:82,771,538...82,775,870

G

ribosomal protein L3

affects expression

Omeprazole affects the expression of RPL3 mRNA

NCBI chr 7:111,622,255...111,627,640
Ensembl chr 7:111,621,610...111,636,468

G

ribosomal protein L32

affects expression

Omeprazole affects the expression of RPL32 mRNA

NCBI chr 4:148,864,048...148,867,612
Ensembl chr 4:148,864,044...148,867,612
Ensembl chr 3:148,864,044...148,867,612

G

ribosomal protein L4

affects expression

Omeprazole affects the expression of RPL4 mRNA

NCBI chr 8:64,671,177...64,676,301
Ensembl chr 8:64,671,160...64,676,306

G

ribophorin II

affects expression

Omeprazole affects the expression of RPN2 mRNA

NCBI chr 3:145,941,787...145,989,271
Ensembl chr 3:145,941,839...145,989,543

G

ribosomal protein S14

affects expression

Omeprazole affects the expression of RPS14 mRNA

NCBI chr18:54,227,854...54,232,638
Ensembl chr18:54,227,854...54,233,166

G

ribosomal protein S18

affects expression

Omeprazole affects the expression of RPS18 mRNA

NCBI chr20:4,931,427...4,935,538
Ensembl chr20:4,931,768...4,938,315

G

ribosomal protein S19

affects expression

Omeprazole affects the expression of RPS19 mRNA

NCBI chr 1:80,480,718...80,486,511
Ensembl chr 1:80,480,951...80,486,508
Ensembl chr 7:80,480,951...80,486,508

G

ribosomal protein S20

affects expression

Omeprazole affects the expression of RPS20 mRNA

NCBI chr 5:16,819,095...16,820,476
Ensembl chr 5:16,819,304...16,820,475
Ensembl chr 9:16,819,304...16,820,475
Ensembl chr 3:16,819,304...16,820,475
Ensembl chr 5:16,819,304...16,820,475

G

ribosomal protein S3a

affects expression

Omeprazole affects the expression of RPS3A mRNA

NCBI chr 2:171,524,685...171,529,054
Ensembl chr 2:171,524,500...171,529,055

G

ribosomal protein S6

affects expression

Omeprazole affects the expression of RPS6 mRNA

NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

ribosomal protein S8

affects expression

Omeprazole affects the expression of RPS8 mRNA

NCBI chr 5:130,630,362...130,632,932
Ensembl chr 5:130,629,716...130,633,268

G

RAS related 2

affects expression

Omeprazole affects the expression of RRAS2 mRNA

NCBI chr 1:168,233,693...168,303,111
Ensembl chr 1:168,233,693...168,303,111

G

RT1 class II, locus DMa

affects expression

Omeprazole affects the expression of HLA-DMA mRNA

NCBI chr20:4,707,028...4,710,432
Ensembl chr20:4,707,028...4,710,432

G

RT1 class Ib, locus M3, gene 1

affects expression

Omeprazole affects the expression of HLA-G mRNA

NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117

G

RT1 class Ib, locus S3

affects expression

Omeprazole affects the expression of RT1-S3 mRNA

NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411

G

sphingosine-1-phosphate receptor 1

affects expression

Omeprazole affects the expression of S1PR1 mRNA

NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681

G

somatomedin B and thrombospondin, type 1 domain containing

affects expression

Omeprazole affects the expression of SBSPON mRNA

NCBI chr 5:3,402,763...3,433,338
Ensembl chr 5:3,402,648...3,435,420

G

syndecan 2

affects expression

Omeprazole affects the expression of SDC2 mRNA

NCBI chr 7:64,127,185...64,239,885
Ensembl chr 7:64,127,110...64,241,081

G

succinate dehydrogenase complex subunit C

affects expression

Omeprazole affects the expression of SDHC mRNA

NCBI chr13:83,544,652...83,565,560
Ensembl chr13:83,544,652...83,566,253

G

succinate dehydrogenase complex subunit D

affects expression

Omeprazole affects the expression of SDHD mRNA

NCBI chr 8:50,944,702...50,954,298
Ensembl chr 8:50,944,704...50,954,238

G

selectin L

decreases expression

Omeprazole results in decreased expression of SELL protein

NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456

G

serine incorporator 3

affects expression

Omeprazole affects the expression of SERINC3 mRNA

NCBI chr 3:152,301,882...152,321,327
Ensembl chr 3:152,301,772...152,321,808

G

serpin family A member 1

affects expression

Omeprazole affects the expression of SERPINA1 mRNA

NCBI chr 6:122,866,314...122,888,339
Ensembl chr 6:122,866,312...122,888,339

G

serpin family A member 10

affects expression

Omeprazole affects the expression of SERPINA10 mRNA

NCBI chr 6:122,756,106...122,764,544
Ensembl chr 6:122,756,108...122,764,544

G

serpin family A member 4

affects expression

Omeprazole affects the expression of SERPINA4 mRNA

NCBI chr 6:122,999,970...123,009,083
Ensembl chr 6:122,999,900...123,009,082

G

serpin family F member 2

affects expression

Omeprazole affects the expression of SERPINF2 mRNA

NCBI chr10:60,272,400...60,280,506
Ensembl chr10:60,272,400...60,281,243

G

serpin family G member 1

decreases expression

Omeprazole results in decreased expression of SERPING1 mRNA

NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034

G

sideroflexin 1

affects expression

Omeprazole affects the expression of SFXN1 mRNA

NCBI chr17:10,486,250...10,522,640
Ensembl chr17:10,486,271...10,522,529

G

serine hydroxymethyltransferase 2

affects expression

Omeprazole affects the expression of SHMT2 mRNA

NCBI chr 7:63,358,961...63,364,293
Ensembl chr 7:63,358,961...63,364,236

G

solute carrier family 22 member 1

affects expression

Omeprazole affects the expression of SLC22A1 mRNA

NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 22 member 2

multiple interactions

Omeprazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 22 member 5

multiple interactions

Dithioerythritol inhibits the reaction [Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]]; Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]

NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309

G

solute carrier family 22 member 8

multiple interactions

[Omeprazole results in decreased activity of SLC22A8 protein] which results in decreased uptake of Indican

NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450

G

solute carrier family 23 member 1

affects expression

Omeprazole affects the expression of SLC23A1 mRNA

NCBI chr18:27,214,940...27,230,564
Ensembl chr18:27,216,281...27,230,697

G

solute carrier family 25 member 13

affects expression

Omeprazole affects the expression of SLC25A13 mRNA

NCBI chr 4:34,179,224...34,361,912
Ensembl chr 4:34,179,224...34,361,902

G

solute carrier family 25 member 3

affects expression

Omeprazole affects the expression of SLC25A3 mRNA

NCBI chr 7:25,611,937...25,619,401
Ensembl chr 7:25,586,725...25,667,727

G

solute carrier family 27 member 2

affects expression

Omeprazole affects the expression of SLC27A2 mRNA

NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208

G

solute carrier family 39 member 8

affects expression

Omeprazole affects the expression of SLC39A8 mRNA

NCBI chr 2:224,171,787...224,319,326
Ensembl chr 2:224,256,654...224,319,129

G

solute carrier family 40 member 1

decreases expression

Omeprazole results in decreased expression of SLC40A1 protein

NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481

G

solute carrier family 46 member 1

affects expression

Omeprazole affects the expression of SLC46A1 mRNA

NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848

G

solute carrier family 66 member 2

affects expression

Omeprazole affects the expression of SLC66A2 mRNA

NCBI chr18:73,702,472...73,739,678
Ensembl chr18:73,702,564...73,739,676

G

solute carrier family 6 member 6

affects expression

Omeprazole affects the expression of SLC6A6 mRNA

NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875

G

solute carrier organic anion transporter family, member 1a4

increases expression

Omeprazole results in increased expression of SLCO1A2 mRNA

NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573

G

superoxide dismutase 1

multiple interactions

Omeprazole inhibits the reaction [Ethanol results in decreased activity of SOD1 protein]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

signal peptide peptidase-like 2A

affects expression

Omeprazole affects the expression of SPPL2A mRNA

NCBI chr 3:114,149,337...114,193,408
Ensembl chr 3:114,151,069...114,193,264

G

spermidine synthase

affects expression

Omeprazole affects the expression of SRM mRNA

NCBI chr 5:159,025,875...159,029,076
Ensembl chr 5:159,025,873...159,029,405

G

SRP receptor subunit beta

affects expression

Omeprazole affects the expression of SRPRB mRNA

NCBI chr 8:103,768,685...103,782,632

G

SSX family member 2 interacting protein

affects expression

Omeprazole affects the expression of SSX2IP mRNA

NCBI chr 2:235,298,012...235,330,750
Ensembl chr 2:235,298,088...235,330,745

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

affects expression

Omeprazole affects the expression of ST3GAL6 mRNA

NCBI chr11:42,061,282...42,121,801
Ensembl chr11:42,077,621...42,121,776

G

ST6 beta-galactoside alpha-2,6-sialyltransferase 1

affects expression

Omeprazole affects the expression of ST6GAL1 mRNA

NCBI chr11:77,526,837...77,653,474
Ensembl chr11:77,526,837...77,653,310

G

succinate-CoA ligase GDP/ADP-forming subunit alpha

affects expression

Omeprazole affects the expression of SUCLG1 mRNA

NCBI chr 4:105,308,236...105,337,595
Ensembl chr 4:105,308,039...105,337,600

G

surfeit 4

affects expression

Omeprazole affects the expression of SURF4 mRNA

NCBI chr 3:10,248,360...10,261,537
Ensembl chr 3:10,241,837...10,263,315

G

synaptojanin 2 binding protein

affects expression

Omeprazole affects the expression of SYNJ2BP mRNA

NCBI chr 6:101,189,714...101,227,400
Ensembl chr 6:101,189,714...101,227,406

G

tachykinin receptor 1

multiple interactions

Omeprazole inhibits the reaction [Acids affects the localization of TACR1 protein]

NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733

G

transforming growth factor, beta 1

increases expression

Omeprazole results in increased expression of TGFB1 protein

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta induced

affects expression

Omeprazole affects the expression of TGFBI mRNA

NCBI chr17:7,955,603...7,984,903
Ensembl chr17:7,955,603...7,985,240

G

threonine synthase-like 2

affects expression

Omeprazole affects the expression of THNSL2 mRNA

NCBI chr 4:103,112,974...103,132,122
Ensembl chr 4:103,112,963...103,132,017

G

translocase of inner mitochondrial membrane 21

affects expression

Omeprazole affects the expression of TIMM21 mRNA

NCBI chr18:78,314,900...78,319,362
Ensembl chr18:78,314,909...78,319,454

G

TIMP metallopeptidase inhibitor 2

multiple interactions

Omeprazole inhibits the reaction [Indomethacin results in increased expression of TIMP2 protein]

NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611

G

triokinase and FMN cyclase

affects expression

Omeprazole affects the expression of TKFC mRNA

NCBI chr 1:207,238,230...207,253,035
Ensembl chr 1:207,236,557...207,252,737

G

toll-like receptor 4

multiple interactions

Lipopolysaccharides inhibits the reaction [Omeprazole inhibits the reaction [Cisplatin results in increased expression of TLR4 protein]]; Omeprazole inhibits the reaction [Cisplatin results in increased expression of TLR4 protein]

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

transmembrane BAX inhibitor motif containing 1

affects expression

Omeprazole affects the expression of TMBIM1 mRNA

NCBI chr 9:75,871,835...75,889,366
Ensembl chr 9:75,871,835...75,889,069

G

transmembrane and coiled-coil domains 1

affects expression

Omeprazole affects the expression of TMCO1 mRNA

NCBI chr13:79,460,229...79,483,557
Ensembl chr13:79,460,135...79,483,555

G

transmembrane p24 trafficking protein 2

affects expression

Omeprazole affects the expression of TMED2 mRNA

NCBI chr12:32,052,542...32,061,628
Ensembl chr12:32,052,543...32,071,903

G

transmembrane p24 trafficking protein 7

affects expression

Omeprazole affects the expression of TMED7 mRNA

NCBI chr18:39,318,564...39,325,640
Ensembl chr18:39,297,351...39,325,640

G

transmembrane protein 123

affects expression

Omeprazole affects the expression of TMEM123 mRNA

NCBI chr 8:4,922,077...4,952,228
Ensembl chr 8:4,922,098...4,952,224

G

transmembrane protein 97

affects expression

Omeprazole affects the expression of TMEM97 mRNA

NCBI chr10:63,438,228...63,447,311
Ensembl chr10:63,438,222...63,589,730

G

transmembrane serine protease 2

increases expression

Omeprazole results in increased expression of TMPRSS2 mRNA

NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715

G

tumor necrosis factor

multiple interactions

Omeprazole inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]
Omeprazole inhibits the reaction [Ethanol results in increased expression of TNF protein]
Omeprazole inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Omeprazole inhibits the reaction [Ethanol results in decreased expression of TNF protein]

PMID:19232345 PMID:25637687 PMID:26970604 PMID:30452898 PMID:32418911

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

thioredoxin 1

affects expression

Omeprazole affects the expression of TXN1 mRNA

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

G

thioredoxin-like 1

affects expression

Omeprazole affects the expression of TXNL1 mRNA

NCBI chr18:57,125,362...57,155,167
Ensembl chr18:57,125,369...57,165,266

G

tyrosinase

multiple interactions
decreases expression

Omeprazole affects the N-linked glycosylation of and results in increased degradation of TYR protein; Omeprazole inhibits the reaction [ATP7A protein results in increased activity of TYR protein]
Omeprazole results in decreased expression of TYR protein

NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207

G

ubiquitin A-52 residue ribosomal protein fusion product 1

affects expression

Omeprazole affects the expression of UBA52 mRNA

NCBI chr16:18,918,614...18,920,807
Ensembl chr16:18,900,616...18,920,807

G

ubiquitin-conjugating enzyme E2N

affects expression

Omeprazole affects the expression of UBE2N mRNA

NCBI chr 7:30,154,330...30,184,373
Ensembl chr 7:30,154,616...30,184,355

G

ubiquitin recognition factor in ER associated degradation 1

affects expression

Omeprazole affects the expression of UFD1 mRNA

NCBI chr11:82,161,618...82,185,107
Ensembl chr11:82,161,619...82,185,087

G

UDP glucuronosyltransferase family 1 member A1

increases expression
affects expression

Omeprazole results in increased expression of UGT1A1 mRNA
Omeprazole affects the expression of UGT1A1 mRNA

PMID:19118567 PMID:19483382 PMID:25626140

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases expression

Omeprazole results in increased expression of UGT1A2 mRNA; Omeprazole results in increased expression of UGT1A3 mRNA

NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glycosyltransferase 1 family, polypeptide A3

increases expression

Omeprazole results in increased expression of UGT1A5 mRNA

NCBI chr 9:88,780,328...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A5

increases expression

Omeprazole results in increased expression of UGT1A4 mRNA

NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A6

multiple interactions
increases expression

[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of UGT1A6 mRNA
Omeprazole results in increased expression of UGT1A6 mRNA

PMID:19118567 PMID:22687989

NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

increases expression

Omeprazole results in increased expression of UGT1A9 mRNA

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 2 family, polypeptide B1

increases expression

Omeprazole results in increased expression of UGT2B1 mRNA

NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986

G

ubiquinol-cytochrome c reductase, complex III subunit XI

affects expression

Omeprazole affects the expression of UQCR11 mRNA

NCBI chr 7:9,305,042...9,309,753
Ensembl chr 7:9,305,058...9,309,750

G

vanin 1

affects expression

Omeprazole affects the expression of VNN1 mRNA

NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395

G

WD repeat domain 26

affects expression

Omeprazole affects the expression of WDR26 mRNA

NCBI chr13:92,930,282...92,972,061
Ensembl chr13:92,930,285...92,977,295

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma

affects expression

Omeprazole affects the expression of YWHAG mRNA

NCBI chr12:20,744,500...20,772,828
Ensembl chr12:20,744,535...20,772,827

G

zinc finger DHHC-type palmitoyltransferase 23

affects expression

Omeprazole affects the expression of ZDHHC23 mRNA

NCBI chr11:56,718,702...56,735,063
Ensembl chr11:56,718,826...56,734,194

G

ZW10 interacting kinetochore protein

affects expression

Omeprazole affects the expression of ZWINT mRNA

NCBI chr20:15,938,157...15,953,997
Ensembl chr20:15,938,157...15,953,957

albendazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenylate cyclase 7

multiple interactions

[Ivermectin co-treated with Albendazole] results in increased expression of ADCY7 mRNA

NCBI chr19:18,740,875...18,798,924
Ensembl chr19:18,740,875...18,776,311

G

ARF like GTPase 4C

multiple interactions

[Ivermectin co-treated with Albendazole] results in decreased expression of ARL4C mRNA

NCBI chr 9:89,300,335...89,303,770
Ensembl chr 9:89,298,005...89,304,513

G

BAG cochaperone 3

multiple interactions

[Ivermectin co-treated with Albendazole] results in increased expression of BAG3 mRNA

NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858

G

C-C motif chemokine ligand 2

increases expression

Albendazole results in increased expression of CCL2 protein

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 3

multiple interactions

[Ivermectin co-treated with Albendazole] results in increased expression of CCL3 protein

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine receptor 7

multiple interactions

[Ivermectin co-treated with Albendazole] results in decreased expression of CCR7 mRNA

NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309

G

chaperonin containing TCP1 subunit 3

multiple interactions

[Ivermectin co-treated with Albendazole] results in increased expression of CCT3 mRNA

NCBI chr 2:173,765,701...173,790,353
Ensembl chr 2:173,765,698...173,790,757

G

CD86 molecule

multiple interactions

[Albendazole co-treated with CYP3A4 protein] results in increased expression of CD86 protein

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

cathepsin L

multiple interactions

[Ivermectin co-treated with Albendazole] results in decreased expression of CTSL mRNA

NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity
decreases activity
increases expression

Albendazole results in increased activity of CYP1A1 promoter; Albendazole results in increased activity of CYP1A1 protein
Albendazole results in decreased activity of CYP1A1 protein
Albendazole results in increased expression of CYP1A1 mRNA

PMID:12451431 PMID:16714371 PMID:18502397 PMID:33814510

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression
affects metabolic processing

Albendazole results in increased expression of CYP1A2 mRNA
CYP1A2 protein affects the metabolism of Albendazole

PMID:12451431 PMID:12920490

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

Albendazole results in decreased activity of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

[SOD2 co-treated with CYP3A4] affects the susceptibility to Albendazole
[Albendazole co-treated with CYP3A4 protein] results in increased expression of CD86 protein; [Albendazole co-treated with CYP3A4 protein] results in increased expression of ICAM1 protein

PMID:19501153 PMID:22785256

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

DnaJ heat shock protein family (Hsp40) member B1

multiple interactions

[Ivermectin co-treated with Albendazole] results in increased expression of DNAJB1 mRNA

NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458

G

dihydropyrimidinase-like 2

multiple interactions

[Ivermectin co-treated with Albendazole] results in increased expression of DPYSL2 mRNA

NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829

G

GTP binding protein overexpressed in skeletal muscle

multiple interactions

[Ivermectin co-treated with Albendazole] results in increased expression of GEM mRNA

NCBI chr 5:25,214,309...25,225,222
Ensembl chr 5:25,214,309...25,225,222

G

G protein-coupled receptor 183

multiple interactions

[Ivermectin co-treated with Albendazole] results in decreased expression of GPR183 mRNA

NCBI chr15:99,037,764...99,050,550
Ensembl chr15:99,036,367...99,050,559

G

heat shock transcription factor 1

increases activity

Albendazole results in increased activity of HSF1 protein

NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011

G

heat shock protein 90 alpha family class A member 1

multiple interactions

[Ivermectin co-treated with Albendazole] results in increased expression of HSP90AA1 mRNA

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

G

heat shock protein 90 alpha family class B member 1

multiple interactions

[Ivermectin co-treated with Albendazole] results in increased expression of HSP90AB1 mRNA

NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488

G

heat shock protein family A (Hsp70) member 4

multiple interactions

[Ivermectin co-treated with Albendazole] results in increased expression of HSPA4 mRNA

NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001

G

heat shock protein family A (Hsp70) member 8

multiple interactions

[Ivermectin co-treated with Albendazole] results in increased expression of HSPA8 mRNA

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

heat shock protein family D (Hsp60) member 1

multiple interactions

[Ivermectin co-treated with Albendazole] results in increased expression of HSPD1 mRNA

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

heat shock protein family E (Hsp10) member 1

multiple interactions

[Ivermectin co-treated with Albendazole] results in increased expression of HSPE1 mRNA

NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089

G

heat shock protein family H (Hsp110) member 1

multiple interactions

[Ivermectin co-treated with Albendazole] results in increased expression of HSPH1 mRNA

NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224

G

intercellular adhesion molecule 1

multiple interactions

[Albendazole co-treated with CYP3A4 protein] results in increased expression of ICAM1 protein

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interleukin 10

multiple interactions

[Ivermectin co-treated with Albendazole] results in increased expression of IL10 protein

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 alpha

multiple interactions

[Ivermectin co-treated with Albendazole] results in increased expression of IL1A protein

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 receptor type 1

multiple interactions

[Ivermectin co-treated with Albendazole] results in increased expression of IL1R1 mRNA

NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937

G

interleukin 6 receptor

increases expression

Albendazole results in increased expression of IL6R protein modified form

NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536

G

mitogen-activated protein kinase kinase kinase 8

multiple interactions

[Ivermectin co-treated with Albendazole] results in decreased expression of MAP3K8 mRNA

NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216

G

microtubule-associated protein tau

decreases expression

Albendazole results in decreased expression of MAPT mRNA; Albendazole results in decreased expression of MAPT protein

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

nuclear receptor subfamily 1, group H, member 4

multiple interactions

Albendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

G

peptidylprolyl isomerase D

multiple interactions

[Ivermectin co-treated with Albendazole] results in decreased expression of PPID mRNA

NCBI chr 2:164,727,803...164,740,168
Ensembl chr 2:164,727,779...164,740,221

G

peptidylprolyl isomerase F

multiple interactions

[Ivermectin co-treated with Albendazole] results in decreased expression of PPIF mRNA

NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913

G

prostaglandin E synthase 3

multiple interactions

[Ivermectin co-treated with Albendazole] results in increased expression of PTGES3 mRNA

NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084

G

RT1 class II, locus DMb

affects expression

Albendazole affects the expression of HLA-DMB mRNA

NCBI chr20:4,693,102...4,700,340
Ensembl chr20:4,693,103...4,700,340

G

src kinase associated phosphoprotein 2

multiple interactions

[Ivermectin co-treated with Albendazole] results in increased expression of SKAP2 mRNA

NCBI chr 4:80,948,832...81,100,900
Ensembl chr 4:80,950,580...81,100,891

G

superoxide dismutase 2

multiple interactions

[SOD2 co-treated with CYP3A4] affects the susceptibility to Albendazole

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

sphingosine kinase 1

multiple interactions

[Ivermectin co-treated with Albendazole] results in decreased expression of SPHK1 mRNA

NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240

G

ST13, Hsp70 interacting protein

multiple interactions

[Ivermectin co-treated with Albendazole] results in increased expression of ST13 mRNA

NCBI chr 7:112,891,007...112,925,727
Ensembl chr 7:112,844,375...112,925,945

G

t-complex 1

multiple interactions

[Ivermectin co-treated with Albendazole] results in increased expression of TCP1 mRNA

NCBI chr 1:47,829,061...47,836,809
Ensembl chr 1:47,828,652...47,836,839

G

TGFB-induced factor homeobox 1

multiple interactions

[Ivermectin co-treated with Albendazole] results in decreased expression of TGIF1 mRNA

NCBI chr 9:110,748,094...110,757,714
Ensembl chr 9:110,720,921...110,757,802

G

tumor necrosis factor

multiple interactions
increases secretion

U 0126 inhibits the reaction [Albendazole results in increased secretion of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

affects activity

Albendazole affects the activity of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

TSC22 domain family, member 1

multiple interactions

[Ivermectin co-treated with Albendazole] results in decreased expression of TSC22D1 mRNA

NCBI chr15:51,750,489...51,850,958
Ensembl chr15:51,749,510...51,850,958

G

vascular endothelial growth factor A

increases expression

Albendazole results in increased expression of VEGFA protein

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

albendazole S-oxide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily G member 2

affects transport

ABCG2 protein affects the transport of albendazole sulfoxide

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

nuclear receptor subfamily 1, group H, member 4

multiple interactions

albendazole sulfoxide inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

G

tumor protein p53

affects activity

albendazole sulfoxide affects the activity of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

astemizole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions
decreases activity

Astemizole inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Astemizole results in decreased activity of ABCB11 protein

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

adenylate kinase 3

increases expression

Astemizole results in increased expression of AK3 mRNA

NCBI chr 1:226,737,472...226,764,647
Ensembl chr 1:226,739,318...226,764,625

G

5'-aminolevulinate synthase 2

increases expression

Astemizole results in increased expression of ALAS2 mRNA

NCBI chr X:19,463,146...19,486,526
Ensembl chr X:19,463,171...19,486,519

G

angiopoietin 2

increases expression

Astemizole results in increased expression of ANGPT2 mRNA

NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804

G

activating transcription factor 3

increases expression

Astemizole results in increased expression of ATF3 mRNA

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

ATPase Na+/K+ transporting subunit beta 1

increases expression

Astemizole results in increased expression of ATP1B1 mRNA

NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459

G

ATPase Na+/K+ transporting subunit beta 2

decreases expression

Astemizole results in decreased expression of ATP1B2 mRNA

NCBI chr10:54,318,698...54,324,933
Ensembl chr10:54,318,701...54,324,933

G

ATP synthase F1 subunit epsilon

increases expression

Astemizole results in increased expression of ATP5F1E mRNA

NCBI chr 3:163,259,072...163,261,974
Ensembl chr 3:163,260,476...163,261,450

G

BCL2, apoptosis regulator

decreases expression

Astemizole results in decreased expression of BCL2 mRNA

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

bone morphogenetic protein 1

decreases expression

Astemizole results in decreased expression of BMP1 mRNA

NCBI chr15:45,551,603...45,595,862
Ensembl chr15:45,551,603...45,595,776

G

calcium/calmodulin-dependent protein kinase II delta

decreases expression

Astemizole results in decreased expression of CAMK2D mRNA

NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178

G

catalase

increases expression

Astemizole results in increased expression of CAT mRNA

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 7

decreases expression

Astemizole results in decreased expression of CCL7 mRNA

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

CCAAT/enhancer binding protein beta

increases expression

Astemizole results in increased expression of CEBPB mRNA

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

CCAAT/enhancer binding protein gamma

decreases expression

Astemizole results in decreased expression of CEBPG mRNA

NCBI chr 1:87,683,060...87,692,772
Ensembl chr 1:87,684,019...87,694,569

G

complement factor H

decreases expression

Astemizole results in decreased expression of CFH mRNA

NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838

G

collectin sub-family member 12

decreases expression

Astemizole results in decreased expression of COLEC12 mRNA

NCBI chr18:732,950...920,620
Ensembl chr18:732,950...920,618

G

cytochrome c oxidase subunit VIc, pseudogene

increases expression

Astemizole results in increased expression of COX6C-PS1 mRNA

NCBI chr19:52,192,612...52,193,470
Ensembl chr19:52,192,612...52,193,470

G

corticotropin releasing hormone

multiple interactions

Astemizole inhibits the reaction [Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]]

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

G

C-X-C motif chemokine ligand 3

decreases expression

Astemizole results in decreased expression of CXCL3 mRNA

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

C-X-C motif chemokine ligand 9

decreases expression

Astemizole results in decreased expression of CXCL9 mRNA

NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435

G

cytochrome P450, family 2, subfamily j, polypeptide 4

multiple interactions
increases metabolic processing
decreases methylation

Arachidonic Acid inhibits the reaction [CYP2J2 protein results in decreased methylation of Astemizole]; ebastine inhibits the reaction [CYP2J2 protein results in decreased methylation of Astemizole]
CYP2J2 protein results in increased metabolism of Astemizole

PMID:12386130 PMID:15861034 PMID:17162467

NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases degradation

CYP3A4 protein results in increased degradation of Astemizole

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

ELL associated factor 1

increases expression

Astemizole results in increased expression of EAF1 mRNA

NCBI chr16:6,698,322...6,713,071
Ensembl chr16:6,698,322...6,713,071

G

egl-9 family hypoxia-inducible factor 1

increases expression

Astemizole results in increased expression of EGLN1 mRNA

NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777

G

eukaryotic translation initiation factor 4A1

increases expression

Astemizole results in increased expression of EIF4A1 mRNA

NCBI chr10:54,384,345...54,389,855
Ensembl chr10:54,384,347...54,389,858

G

ERBB receptor feedback inhibitor 1

decreases expression

Astemizole results in decreased expression of ERRFI1 mRNA

NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282

G

ETS variant transcription factor 5

decreases expression

Astemizole results in decreased expression of ETV5 mRNA

NCBI chr11:78,608,618...78,666,221
Ensembl chr11:78,608,710...78,666,215

G

family with sequence similarity 124 member A

increases expression

Astemizole results in increased expression of FAM124A mRNA

NCBI chr15:36,799,836...36,855,062
Ensembl chr15:36,799,877...36,853,683

G

Fc epsilon receptor Ia

multiple interactions

Astemizole inhibits the reaction [FCER1A protein results in increased secretion of HEXB protein]

NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351

G

growth differentiation factor 10

increases expression

Astemizole results in increased expression of GDF10 mRNA

NCBI chr16:9,237,182...9,250,537
Ensembl chr16:9,237,261...9,249,343

G

GTPase, IMAP family member 1

increases expression

Astemizole results in increased expression of GIMAP1 mRNA

NCBI chr 4:77,687,581...77,691,468
Ensembl chr 4:77,682,171...77,691,866

G

glycoprotein m6b

increases expression

Astemizole results in increased expression of GPM6B mRNA

NCBI chr X:28,057,788...28,204,409
Ensembl chr X:28,059,450...28,204,211

G

glutathione peroxidase 4

increases expression

Astemizole results in increased expression of GPX4 mRNA

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

hexosaminidase subunit beta

increases secretion
multiple interactions

Astemizole results in increased secretion of HEXB protein
Astemizole inhibits the reaction [FCER1A protein results in increased secretion of HEXB protein]

NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223

G

heme oxygenase 1

increases expression

Astemizole results in increased expression of HMOX1 mRNA

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

histamine receptor H 1

multiple interactions

[Astemizole binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Aminophylline
Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]]

PMID:12147327 PMID:16129921

NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455

G

heat shock protein 90 alpha family class B member 1

decreases expression

Astemizole results in decreased expression of HSP90AB1 mRNA

NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488

G

heat shock protein family A (Hsp70) member 8

increases expression

Astemizole results in increased expression of HSPA8 mRNA

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

heat shock protein family B (small) member 8

increases expression

Astemizole results in increased expression of HSPB8 mRNA

NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185

G

heat shock protein family H (Hsp110) member 1

decreases expression

Astemizole results in decreased expression of HSPH1 mRNA

NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224

G

intercellular adhesion molecule 1

multiple interactions

Astemizole inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interferon-induced protein with tetratricopeptide repeats 3

decreases expression

Astemizole results in decreased expression of IFIT3 mRNA

NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307

G

insulin-like growth factor 1

multiple interactions

Astemizole inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein]

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

immunoglobulin superfamily, member 6

decreases expression

Astemizole results in decreased expression of IGSF6 mRNA

NCBI chr 1:175,610,167...175,620,662
Ensembl chr 1:175,610,167...175,620,722

G

interleukin 1 beta

multiple interactions

Astemizole inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Astemizole inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 36 receptor antagonist

increases expression

Astemizole results in increased expression of IL36RN mRNA

NCBI chr 3:7,044,419...7,051,016
Ensembl chr 3:7,044,406...7,051,016

G

interleukin 7 receptor

decreases expression

Astemizole results in decreased expression of IL7R mRNA

NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757

G

integrin subunit alpha 8

increases expression

Astemizole results in increased expression of ITGA8 mRNA

NCBI chr17:75,304,004...75,501,510
Ensembl chr17:75,304,008...75,501,510

G

potassium voltage-gated channel subfamily H member 1

multiple interactions
decreases activity
affects binding

Astemizole binds to and results in decreased activity of KCNH1 protein; Astemizole inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein]
Astemizole results in decreased activity of KCNH1 protein
Astemizole binds to KCNH1 protein

PMID:14985237 PMID:16816845 PMID:17520698 PMID:18471075 PMID:18497958 More...

NCBI chr13:103,722,140...104,024,762
Ensembl chr13:103,722,245...104,024,740

G

potassium voltage-gated channel subfamily H member 2

multiple interactions
affects binding
decreases activity
affects localization

Astemizole binds to and results in decreased activity of KCNH2 protein; Astemizole inhibits the reaction [arsenic trioxide results in increased degradation of KCNH2 protein]; Astemizole inhibits the reaction [Digoxin results in decreased activity of KCNH2 protein]; Astemizole inhibits the reaction [Digoxin results in decreased metabolism of KCNH2 protein modified form]; Astemizole inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; dofetilide analog inhibits the reaction [Astemizole binds to KCNH2 protein]; Hydrogen Peroxide inhibits the reaction [Astemizole results in decreased activity of KCNH2 protein mutant form]; Potassium promotes the reaction [Astemizole binds to KCNH2 protein]
Astemizole binds to KCNH2 gene polymorphism; Astemizole binds to KCNH2 protein
Astemizole affects the localization of KCNH2 protein mutant form

PMID:8641472 PMID:9658196 PMID:10376921 PMID:10422790 PMID:10531299 More...

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

potassium voltage-gated channel subfamily Q member 2

multiple interactions

Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]]

NCBI chr 3:168,194,776...168,253,831
Ensembl chr 3:168,195,357...168,275,071

G

potassium voltage-gated channel subfamily Q member 3

multiple interactions

Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]]

NCBI chr 7:97,730,219...98,025,652
Ensembl chr 7:97,730,465...98,025,653

G

monoamine oxidase A

decreases expression

Astemizole results in decreased expression of MAOA mRNA

NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593

G

microtubule-associated protein tau

affects binding

Astemizole binds to MAPT protein alternative form

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

matrix metallopeptidase 2

decreases expression

Astemizole results in decreased expression of MMP2 mRNA

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

membrane spanning 4-domains A6A

decreases expression

Astemizole results in decreased expression of MS4A6A mRNA

NCBI chr 1:208,401,465...208,414,831
Ensembl chr 1:208,401,466...208,414,758

G

metallothionein 2A

increases expression

Astemizole results in increased expression of MT2A mRNA

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

metal-regulatory transcription factor 1

multiple interactions

MTF1 protein affects the reaction [Astemizole results in increased expression of MT1M mRNA]

NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136

G

microtubule associated scaffold protein 1

decreases expression

Astemizole results in decreased expression of MTUS1 mRNA

NCBI chr16:51,202,497...51,347,794
Ensembl chr16:51,253,562...51,347,793

G

myosin heavy chain 6

increases expression

Astemizole results in increased expression of MYH6 mRNA

NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720

G

NADH:ubiquinone oxidoreductase core subunit S7

increases expression

Astemizole results in increased expression of NDUFS7 mRNA

NCBI chr 7:9,452,556...9,460,135
Ensembl chr 7:9,450,392...9,460,195

G

NADH:ubiquinone oxidoreductase core subunit V2

increases expression

Astemizole results in increased expression of NDUFV2 mRNA

NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713

G

N-terminal EF-hand calcium binding protein 1

decreases expression

Astemizole results in decreased expression of NECAB1 mRNA

NCBI chr 5:28,357,859...28,578,642
Ensembl chr 5:28,357,859...28,578,642
Ensembl chr 5:28,357,859...28,578,642

G

nuclear receptor subfamily 4, group A, member 3

increases expression

Astemizole results in increased expression of NR4A3 mRNA

NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733

G

2'-5'-oligoadenylate synthetase-like

decreases expression

Astemizole results in decreased expression of OASL1 mRNA

NCBI chr12:41,682,900...41,695,641
Ensembl chr12:41,682,900...41,695,641

G

oxysterol binding protein-like 3

increases expression

Astemizole results in increased expression of OSBPL3 mRNA

NCBI chr 4:79,346,583...79,523,523
Ensembl chr 4:79,350,349...79,523,393

G

O-sialoglycoprotein endopeptidase-like 1

increases expression

Astemizole results in increased expression of OSGEPL1 mRNA

NCBI chr 9:48,214,995...48,229,440
Ensembl chr 9:48,215,402...48,229,388

G

Parkinsonism associated deglycase

increases expression

Astemizole results in increased expression of PARK7 mRNA

NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970

G

protocadherin 17

decreases expression

Astemizole results in decreased expression of PCDH17 mRNA

NCBI chr15:60,222,088...60,316,172
Ensembl chr15:60,222,004...60,313,999

G

pellino E3 ubiquitin protein ligase family member 2

increases expression

Astemizole results in increased expression of PELI2 mRNA

NCBI chr15:21,393,262...21,537,737
Ensembl chr15:21,393,262...21,535,106

G

prolactin family 8, subfamily A, member 3

decreases expression

Astemizole results in decreased expression of PRL8A3 mRNA

NCBI chr17:37,508,328...37,514,832
Ensembl chr17:37,508,328...37,514,825

G

proteasome 20S subunit beta 5

increases expression

Astemizole results in increased expression of PSMB5 mRNA

NCBI chr15:28,072,772...28,077,367
Ensembl chr15:28,072,781...28,077,440

G

prostaglandin-endoperoxide synthase 1

decreases expression

Astemizole results in decreased expression of PTGS1 mRNA

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

G

pyrroline-5-carboxylate reductase 3

increases expression

Astemizole results in increased expression of PYCR3 mRNA

NCBI chr 7:107,603,543...107,608,831
Ensembl chr 7:107,581,930...107,608,799

G

glycogen phosphorylase, muscle associated

increases expression

Astemizole results in increased expression of PYGM mRNA

NCBI chr 1:203,690,550...203,705,369
Ensembl chr 1:203,690,533...203,705,368

G

S100 calcium binding protein A8

increases expression

Astemizole results in increased expression of S100A8 mRNA

NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643

G

S100 calcium binding protein B

decreases expression

Astemizole results in decreased expression of S100B mRNA

NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743

G

salt-inducible kinase 1

decreases expression

Astemizole results in decreased expression of SIK1 mRNA

NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991

G

solute carrier family 1 member 1

increases expression

Astemizole results in increased expression of SLC1A1 mRNA

NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402

G

superoxide dismutase 2

increases expression

Astemizole results in increased expression of SOD2 mRNA

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

sequestosome 1

increases expression

Astemizole results in increased expression of SQSTM1 mRNA

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

transferrin

decreases expression

Astemizole results in decreased expression of TF mRNA

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

G

transforming growth factor, beta 2

increases expression

Astemizole results in increased expression of TGFB2 mRNA

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

G

toll-like receptor 2

decreases expression

Astemizole results in decreased expression of TLR2 mRNA

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

G

toll-like receptor 7

decreases expression

Astemizole results in decreased expression of TLR7 mRNA

NCBI chr X:27,027,380...27,054,309
Ensembl chr X:27,027,425...27,054,754

G

tropomodulin 1

increases expression

Astemizole results in increased expression of TMOD1 mRNA

NCBI chr 5:60,316,445...60,393,957
Ensembl chr 5:60,338,512...60,393,956

G

vascular cell adhesion molecule 1

multiple interactions

Astemizole inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

versican

decreases expression

Astemizole results in decreased expression of VCAN mRNA

NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637

azilsartan

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

multiple interactions

[Zinc Sulfate binds to azilsartan] which results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

Bcl2-like 1

multiple interactions

[Zinc Sulfate binds to azilsartan] which results in decreased expression of BCL2L1 protein

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

caspase 9

multiple interactions

[Zinc Sulfate binds to azilsartan] which results in increased expression of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

benomyl

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ADAM metallopeptidase domain 33

multiple interactions
increases expression

ORMDL3 protein affects the reaction [Benomyl results in increased expression of ADAM33 protein]

NCBI chr 3:118,262,395...118,283,456
Ensembl chr 3:118,271,029...118,283,461

G

AKT serine/threonine kinase 1

decreases expression

Benomyl results in decreased expression of AKT1 mRNA

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aldehyde dehydrogenase 2 family member

decreases activity

Benomyl metabolite results in decreased activity of ALDH2 protein; Benomyl results in decreased activity of ALDH2 protein

PMID:9585485 PMID:10513990 PMID:11142365 PMID:15331769 PMID:17010440

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

G

aldehyde dehydrogenase 5 family, member A1

decreases activity

Benomyl results in decreased activity of ALDH5A1 protein

NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677

G

adenosine monophosphate deaminase 3

decreases expression

Benomyl results in decreased expression of AMPD3 mRNA

NCBI chr 1:164,884,823...164,929,899
Ensembl chr 1:164,885,320...164,929,887

G

androgen receptor

multiple interactions

Benomyl inhibits the reaction [Dihydrotestosterone affects the localization of and results in increased phosphorylation of AR protein]

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

BCL2 associated X, apoptosis regulator

multiple interactions

Benomyl inhibits the reaction [BCL2 protein binds to BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions
increases phosphorylation

Benomyl inhibits the reaction [BCL2 protein binds to BAX protein]
Benomyl results in increased phosphorylation of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BUB1 mitotic checkpoint serine/threonine kinase B

increases expression

Benomyl results in increased expression of BUB1B protein

NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547

G

carbonic anhydrase 2

increases expression

Benomyl results in increased expression of CA2 mRNA

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

C-C motif chemokine ligand 17

increases expression
multiple interactions

Benomyl results in increased expression of CCL17 mRNA
ORMDL3 protein affects the reaction [Benomyl results in increased expression of CCL17 mRNA]

NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819

G

cyclin B1

increases response to substance

CCNB1 protein results in increased susceptibility to Benomyl

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin B2

increases response to substance

CCNB2 protein results in increased susceptibility to Benomyl

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

CD38 molecule

decreases expression

Benomyl results in decreased expression of CD38 mRNA

NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases expression
multiple interactions

Benomyl results in decreased expression of CYP17A1 mRNA
Benomyl results in decreased expression of and results in decreased activity of CYP17A1 protein

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

increases activity
increases expression

Benomyl results in increased activity of CYP19A1 protein
Benomyl results in increased expression of CYP19A1 mRNA

PMID:14691014 PMID:25543211

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [Benomyl results in increased expression of DDIT3 protein]; MitoTEMPO inhibits the reaction [Benomyl results in increased expression of DDIT3 protein]

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

eukaryotic translation initiation factor 2 alpha kinase 3

increases expression
multiple interactions

Benomyl results in increased expression of EIF2AK3 protein
Acetylcysteine inhibits the reaction [Benomyl results in increased expression of EIF2AK3 protein]; MitoTEMPO inhibits the reaction [Benomyl results in increased expression of EIF2AK3 protein]

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [Benomyl results in increased expression of ERN1 protein]; MitoTEMPO inhibits the reaction [Benomyl results in increased expression of ERN1 protein]

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

estrogen receptor 1

multiple interactions
affects binding

Benomyl binds to and results in increased activity of ESR1 protein; Benomyl inhibits the reaction [Estradiol binds to ESR1 protein]
Benomyl binds to ESR1 protein

PMID:14579009 PMID:16626760

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

fibroblast growth factor receptor 4

increases expression

Benomyl results in increased expression of FGFR4 mRNA

NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242

G

GIPC PDZ domain containing family, member 1

increases expression

Benomyl results in increased expression of GIPC1 mRNA

NCBI chr19:24,474,291...24,487,083
Ensembl chr19:24,453,123...24,486,997

G

glycine-N-acyltransferase

increases expression

Benomyl results in increased expression of GLYAT mRNA

NCBI chr 1:209,704,213...209,724,949
Ensembl chr 1:209,704,268...209,724,942

G

histone deacetylase 1

decreases activity

Benomyl results in decreased activity of HDAC1 protein

NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111

G

heat shock protein family A (Hsp70) member 5

increases expression
multiple interactions

Benomyl results in increased expression of HSPA5 protein
Acetylcysteine inhibits the reaction [Benomyl results in increased expression of HSPA5 protein]; MitoTEMPO inhibits the reaction [Benomyl results in increased expression of HSPA5 protein]

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family B (small) member 1

increases expression

Benomyl results in increased expression of HSPB1 mRNA

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

interferon beta 1

multiple interactions

Benomyl inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]

NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523

G

integrin subunit alpha 5

decreases expression

Benomyl results in decreased expression of ITGA5 mRNA

NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837

G

integrin subunit beta 1

decreases expression

Benomyl results in decreased expression of ITGB1 mRNA

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

G

kallikrein 1-related peptidase C10

multiple interactions

Benomyl inhibits the reaction [Dihydrotestosterone results in increased secretion of KLK3 protein]

NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052

G

mitogen-activated protein kinase 8

increases expression

Benomyl results in increased expression of MAPK8 mRNA

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

microRNA 21

decreases expression

Benomyl results in decreased expression of MIR21 mRNA

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

G

matrix metallopeptidase 2

decreases expression
multiple interactions
increases expression

Benomyl results in decreased expression of MMP2 mRNA
ORMDL3 protein affects the reaction [Benomyl results in increased expression of MMP2 protein]

PMID:25530041 PMID:27784618

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

decreases expression

Benomyl results in decreased expression of MMP9 protein
Benomyl results in decreased expression of MMP9 mRNA

PMID:10026946 PMID:25530041

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

multimerin 1

increases expression

Benomyl results in increased expression of MMRN1 mRNA

NCBI chr 4:89,875,408...89,950,814
Ensembl chr 4:89,903,174...89,950,474

G

microseminoprotein, beta

increases expression

Benomyl results in increased expression of MSMB mRNA

NCBI chr16:7,366,536...7,387,124
Ensembl chr16:7,366,536...7,387,123

G

metallothionein 2A

increases expression

Benomyl results in increased expression of MT2A mRNA

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

nuclear factor kappa B subunit 1

multiple interactions

Benomyl inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein]

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

nuclear receptor subfamily 1, group H, member 4

multiple interactions

Benomyl inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

G

olfactory receptor family 10 subfamily AL member 27

increases expression

Benomyl results in increased expression of OR10AL27 mRNA

NCBI chr20:789,272...790,237
Ensembl chr20:761,025...765,744
Ensembl chr20:761,025...765,744

G

olfactory receptor family 13 subfamily P member 4

increases expression

Benomyl results in increased expression of OR13P4 mRNA

NCBI chr 5:132,216,822...132,217,769
Ensembl chr 5:132,215,327...132,221,481

G

olfactory receptor family 9 subfamily S member 23B

increases expression

Benomyl results in increased expression of OR9S23B mRNA

NCBI chr 9:93,117,328...93,118,299
Ensembl chr 9:93,115,232...93,123,441

G

ORMDL sphingolipid biosynthesis regulator 3

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [Benomyl results in increased expression of ORMDL3 protein]; MitoTEMPO inhibits the reaction [Benomyl results in increased expression of ORMDL3 protein]; ORMDL3 protein affects the reaction [Benomyl results in increased expression of ADAM33 protein]; ORMDL3 protein affects the reaction [Benomyl results in increased expression of CCL17 mRNA]; ORMDL3 protein affects the reaction [Benomyl results in increased expression of CXCL8 mRNA]; ORMDL3 protein affects the reaction [Benomyl results in increased expression of MMP2 protein]; ORMDL3 protein affects the reaction [Benomyl results in increased expression of TSLP mRNA]

NCBI chr10:83,590,052...83,596,035
Ensembl chr10:83,590,071...83,598,620

G

Parkinsonism associated deglycase

decreases activity

Benomyl results in decreased activity of PARK7 protein

NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970

G

poly (ADP-ribose) polymerase 1

increases cleavage

Benomyl results in increased cleavage of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

plasminogen activator, urokinase

decreases expression

Benomyl results in decreased expression of PLAU mRNA

NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775

G

phosphatase and tensin homolog

increases expression

Benomyl results in increased expression of PTEN mRNA

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

G

RELA proto-oncogene, NF-kB subunit

increases expression

Benomyl results in increased expression of RELA mRNA

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

stearoyl-CoA desaturase

decreases expression

Benomyl results in decreased expression of SCD1 mRNA

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

serpin family E member 2

increases expression

Benomyl results in increased expression of SERPINE2 mRNA

NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826

G

SH2 domain containing 4A

increases expression

Benomyl results in increased expression of SH2D4A mRNA

NCBI chr16:21,339,010...21,409,360
Ensembl chr16:21,340,015...21,409,260

G

TIMP metallopeptidase inhibitor 1

increases expression

Benomyl results in increased expression of TIMP1 mRNA

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

TIMP metallopeptidase inhibitor 2

increases expression

Benomyl results in increased expression of TIMP2 mRNA

NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611

G

tumor necrosis factor

decreases expression

Benomyl results in decreased expression of TNF mRNA

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

affects activity

Benomyl affects the activity of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

thymic stromal lymphopoietin

increases expression
multiple interactions

Benomyl results in increased expression of TSLP mRNA
ORMDL3 protein affects the reaction [Benomyl results in increased expression of TSLP mRNA]

NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548

G

ubiquitin-like modifier activating enzyme 1

multiple interactions

Benomyl results in increased activity of and results in increased ubiquitination of UBA1 protein

NCBI chr X:1,508,700...1,530,677
Ensembl chr X:1,508,666...1,530,636

G

vasodilator-stimulated phosphoprotein

multiple interactions

Benomyl inhibits the reaction [Nitroglycerin results in increased phosphorylation of VASP protein]; Benomyl inhibits the reaction [Pentaerythritol Tetranitrate results in increased phosphorylation of VASP protein]

NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061

binimetinib

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

[NADP co-treated with binimetinib] results in decreased activity of CYP1A2 protein

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

candesartan

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

affects expression

candesartan affects the expression of ACE mRNA

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

angiotensin converting enzyme 2

decreases expression

candesartan results in decreased expression of ACE2 mRNA

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

adiponectin, C1Q and collagen domain containing

multiple interactions
increases expression
decreases expression

[candesartan co-treated with Fenofibrate] results in increased expression of ADIPOQ protein; candesartan promotes the reaction [Ramipril results in increased expression of ADIPOQ]; Ramipril promotes the reaction [candesartan results in increased expression of ADIPOQ]
candesartan results in increased expression of ADIPOQ; candesartan results in increased expression of ADIPOQ protein
candesartan results in decreased expression of ADIPOQ

PMID:16443859 PMID:17483542 PMID:19059660

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

angiotensinogen

multiple interactions

candesartan inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]; candesartan inhibits the reaction [AGT protein results in increased chemical synthesis of Nitric Oxide]; candesartan inhibits the reaction [AGT protein results in increased chemical synthesis of Reactive Oxygen Species]
candesartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; candesartan inhibits the reaction [AGT protein promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; candesartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; candesartan inhibits the reaction [AGT protein results in increased expression of ENG protein]; candesartan inhibits the reaction [AGT protein results in increased expression of IL6 protein]; candesartan inhibits the reaction [AGT protein results in increased expression of PTHLH mRNA]; candesartan inhibits the reaction [AGT protein results in increased expression of PTHLH protein]; candesartan inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; candesartan inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; candesartan inhibits the reaction [Folic Acid results in increased localization of [AGT protein binds to AGTR1A protein]]
candesartan inhibits the reaction [AGT protein modified form results in increased expression of COL1A2 protein]; candesartan inhibits the reaction [AGT results in increased expression of NOS3 protein]; candesartan inhibits the reaction [AGT results in increased expression of PTGS2 protein]; candesartan inhibits the reaction [AGT results in increased expression of VEGFA protein]

PMID:10525314 PMID:11729239 PMID:12065685 PMID:15539634 PMID:15728788 More...

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 1a

multiple interactions
decreases expression

candesartan binds to and results in decreased activity of AGTR1 protein
candesartan inhibits the reaction [Folic Acid results in increased localization of [AGT protein binds to AGTR1A protein]]
candesartan results in decreased expression of AGTR1A mRNA

PMID:15728788 PMID:18796534 PMID:21474964

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

G

angiotensin II receptor, type 2

multiple interactions
decreases expression

[PD 123319 binds to and results in decreased activity of AGTR2 protein] inhibits the reaction [candesartan results in increased expression of NOS3 protein]
candesartan results in decreased expression of AGTR2 mRNA

PMID:18551021 PMID:18796534

NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057

G

A-kinase anchoring protein 11

increases expression

candesartan results in increased expression of AKAP11 mRNA

NCBI chr15:53,911,635...53,956,138
Ensembl chr15:53,911,657...53,941,605

G

aldo-keto reductase family 1 member B1

decreases expression

candesartan results in decreased expression of AKR1B1 mRNA

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

AKT serine/threonine kinase 1

decreases phosphorylation

candesartan results in decreased phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

autophagy related 5

multiple interactions

candesartan inhibits the reaction [Galactose results in decreased expression of ATG5 mRNA]

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

multiple interactions

candesartan inhibits the reaction [Isoproterenol results in decreased expression of ATP2A2 protein]

NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101

G

BCL2 associated X, apoptosis regulator

increases expression

candesartan results in increased expression of BAX mRNA; candesartan results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

bradykinin receptor B2

decreases expression

candesartan results in decreased expression of BDKRB2 mRNA

NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497

G

beclin 1

multiple interactions

candesartan inhibits the reaction [Galactose results in decreased expression of BECN1 mRNA]

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

carbonic anhydrase 1

decreases activity

candesartan results in decreased activity of CA1 protein

NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208

G

caspase 3

multiple interactions

[candesartan co-treated with epigallocatechin gallate] inhibits the reaction [Gentamicins results in increased expression of CASP3 protein]; candesartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; candesartan inhibits the reaction [Gentamicins results in increased expression of CASP3 protein]

PMID:23300732 PMID:30368989

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions

candesartan inhibits the reaction [Galactose results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cellular communication network factor 2

decreases expression

candesartan results in decreased expression of CCN2 mRNA

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

CD36 molecule

multiple interactions
decreases expression
increases expression

T 0070907 inhibits the reaction [candesartan results in increased expression of CD36 mRNA]
candesartan results in decreased expression of CD36 mRNA

PMID:14871019 PMID:22124178

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

CD40 ligand

multiple interactions
decreases expression

candesartan promotes the reaction [Fenofibrate results in decreased expression of CD40LG protein]; Fenofibrate promotes the reaction [candesartan results in decreased expression of CD40LG protein]

NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306

G

collagen type I alpha 2 chain

multiple interactions

candesartan inhibits the reaction [AGT protein modified form results in increased expression of COL1A2 protein]

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

cysteine-rich secretory protein LCCL domain containing 2

decreases expression

candesartan results in decreased expression of CRISPLD2 mRNA

NCBI chr19:48,053,153...48,111,485
Ensembl chr19:48,053,287...48,110,465

G

C-reactive protein

multiple interactions
decreases expression

candesartan promotes the reaction [Fenofibrate results in decreased expression of CRP protein]; Fenofibrate promotes the reaction [candesartan results in decreased expression of CRP protein]

PMID:14620923 PMID:16443859

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

C-X-C motif chemokine ligand 1

multiple interactions

candesartan inhibits the reaction [Indomethacin results in increased expression of CXCL1 protein]

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

cytochrome b-245 alpha chain

decreases expression
multiple interactions

candesartan results in decreased expression of CYBA protein
candesartan results in decreased expression of CYBA; candesartan results in decreased expression of CYBA mRNA
Amlodipine promotes the reaction [candesartan results in decreased expression of CYBA]; candesartan inhibits the reaction [Streptozocin results in increased expression of CYBA mRNA]; Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of CYBA]

PMID:16139267 PMID:16685210 PMID:18551021 PMID:21107329

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

cytochrome b-245 beta chain

multiple interactions
decreases expression

Amlodipine promotes the reaction [candesartan results in decreased expression of CYBB]; Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of CYBB]
candesartan results in decreased expression of CYBB; candesartan results in decreased expression of CYBB mRNA

PMID:16685210 PMID:21107329

NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586

G

cytochrome P450, family 11, subfamily b, polypeptide 3

affects response to substance
decreases expression

CYP11B2 protein polymorphism affects the susceptibility to candesartan
candesartan results in decreased expression of CYP11B2 mRNA

PMID:12065207 PMID:18796534

NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048

G

endoglin

multiple interactions

candesartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; candesartan inhibits the reaction [AGT protein results in increased expression of ENG protein]

NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230

G

Fas ligand

multiple interactions

candesartan inhibits the reaction [Daunorubicin results in increased expression of FASLG protein]

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

candesartan inhibits the reaction [[Acetaldehyde co-treated with Cyanamide] results in increased expression of FOS protein]; candesartan inhibits the reaction [Acetaldehyde promotes the reaction [Cyanamide results in increased expression of FOS protein]]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box O1

multiple interactions

[GCG protein co-treated with candesartan] inhibits the reaction [Palmitic Acid results in decreased phosphorylation of FOXO1 protein]; candesartan inhibits the reaction [Palmitic Acid results in decreased phosphorylation of FOXO1 protein]

NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790

G

glucagon

multiple interactions

[GCG protein co-treated with candesartan] inhibits the reaction [Palmitic Acid results in decreased phosphorylation of FOXO1 protein]; [GCG protein co-treated with candesartan] inhibits the reaction [Palmitic Acid results in decreased phosphorylation of IRS2 protein]

NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929

G

glial cell derived neurotrophic factor

multiple interactions

candesartan inhibits the reaction [Galactose results in decreased expression of GDNF mRNA]

NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209

G

heat shock protein family E (Hsp10) member 1

decreases expression

candesartan results in decreased expression of HSPE1 mRNA

NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089

G

intercellular adhesion molecule 1

multiple interactions

candesartan inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

inhibitor of DNA binding 1

decreases expression

candesartan results in decreased expression of ID1 mRNA

NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419

G

interleukin 1 beta

multiple interactions

[candesartan co-treated with epigallocatechin gallate] inhibits the reaction [Gentamicins results in increased expression of IL1B protein]; candesartan inhibits the reaction [Gentamicins results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

candesartan inhibits the reaction [AGT protein promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; candesartan inhibits the reaction [AGT protein results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin receptor substrate 2

multiple interactions

[GCG protein co-treated with candesartan] inhibits the reaction [Palmitic Acid results in decreased phosphorylation of IRS2 protein]; candesartan inhibits the reaction [Palmitic Acid results in decreased phosphorylation of IRS2 protein]

NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482

G

potassium calcium-activated channel subfamily N member 4

decreases expression

candesartan decreases expression of KCNN4 mRNA and protein in CD4-positive, alpha-beta T cell

RGD

NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340

G

kallikrein 1

decreases expression

candesartan results in decreased expression of KLK1 mRNA

NCBI chr 1:94,642,644...94,646,760
Ensembl chr 1:94,642,687...94,646,754

G

leptin

multiple interactions
increases response to substance
decreases expression

candesartan promotes the reaction [Ramipril results in increased expression of LEP]; Ramipril promotes the reaction [candesartan results in increased expression of LEP]
LEP protein results in increased susceptibility to candesartan
candesartan results in decreased expression of LEP

PMID:17483542 PMID:19059660 PMID:21287150

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

mitogen activated protein kinase 1

multiple interactions

candesartan inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

candesartan inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

candesartan inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

matrix metallopeptidase 13

increases expression

candesartan results in increased expression of MMP13 protein

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 15

increases expression

candesartan results in increased expression of MMP15 mRNA

NCBI chr19:9,663,449...9,684,943
Ensembl chr19:9,663,449...9,684,943

G

matrix metallopeptidase 9

decreases expression

candesartan results in decreased expression of MMP9 mRNA; candesartan results in decreased expression of MMP9 protein

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

multiple interactions

candesartan inhibits the reaction [Indomethacin results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

nitric oxide synthase 2

multiple interactions

candesartan inhibits the reaction [Streptozocin results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

multiple interactions

[PD 123319 binds to and results in decreased activity of AGTR2 protein] inhibits the reaction [candesartan results in increased expression of NOS3 protein]
candesartan inhibits the reaction [Streptozocin results in increased expression of NOS3 mRNA]; candesartan inhibits the reaction [Streptozocin results in increased expression of NOS3 protein]
candesartan inhibits the reaction [AGT results in increased expression of NOS3 protein]

PMID:12065685 PMID:16139267 PMID:18551021

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

NADPH oxidase 1

multiple interactions
decreases expression

Amlodipine promotes the reaction [candesartan results in decreased expression of NOX1]; Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of NOX1]

NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236

G

NADPH oxidase 4

decreases expression
multiple interactions

candesartan results in decreased expression of NOX4 protein
Amlodipine promotes the reaction [candesartan results in decreased expression of NOX4]; Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of NOX4]

PMID:18551021 PMID:21107329

NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406

G

natriuretic peptide A

increases expression
increases secretion

candesartan results in increased expression of NPPA mRNA; candesartan results in increased expression of NPPA protein
candesartan results in increased secretion of NPPA protein

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

nuclear receptor subfamily 3, group C, member 2

affects expression

candesartan affects the expression of NR3C2 mRNA

NCBI chr19:30,715,634...31,059,885