CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: barbiturates
Accession: CHEBI:22693
browse the term
Definition: Members of the class of pyrimidones consisting of pyrimidine-2,4,6(1H,3H,5H)-trione (barbituric acid) and its derivatives. Largest group of the synthetic sedative/hypnotics, sharing a characteristic six-membered ring structure.
Synonyms: related_synonym: barbituric acids
xref_mesh: MESH:D001463
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Path 1
CHEBI ontology
19880
role
19850
biological role
19848
biophysical role
14048
membrane transport modulator
13884
GABA modulator
5114
barbiturates
4626
1,3-dimethyl-5-[1-(1-phenylethylamino)propylidene]-1,3-diazinane-2,4,6-trione
0
1-(3,4-dimethylphenyl)-5-[[(4-methoxyphenyl)hydrazo]methylidene]-1,3-diazinane-2,4,6-trione
0
1-(3-bromophenyl)-5-(3-thiophenylmethylidene)-1,3-diazinane-2,4,6-trione
0
1-(3-chloropropyl)-5-[[(2-chloro-3-pyridinyl)amino]methylidene]-3-cyclohexyl-1,3-diazinane-2,4,6-trione
0
1-(3-methoxyphenyl)-5-[(5-nitro-2-thiophenyl)methylidene]-1,3-diazinane-2,4,6-trione
0
1-(4-bromophenyl)-5-[(1,2,5-trimethyl-3-pyrrolyl)methylidene]-1,3-diazinane-2,4,6-trione
0
1-(4-chlorophenyl)-5-[(1,2,5-trimethyl-3-pyrrolyl)methylidene]-1,3-diazinane-2,4,6-trione
0
1-(4-chlorophenyl)-5-[1-(2-oxolanylmethylamino)ethylidene]-1,3-diazinane-2,4,6-trione
0
1-[(2-chlorophenyl)methyl]-5-[(5-methyl-2-furanyl)methylidene]-1,3-diazinane-2,4,6-trione
0
1-[(4-fluorophenyl)methyl]-5-(thiophen-2-ylmethylidene)-1,3-diazinane-2,4,6-trione
0
1-[1-(1,3-dimethyl-2,4,6-trioxo-1,3-diazinan-5-ylidene)ethylamino]-3-phenylthiourea
0
1-[2-(1-cyclohexenyl)ethyl]-5-[[4-(diethylamino)anilino]methylidene]-1,3-diazinane-2,4,6-trione
0
1-butyl-5-[1-(2-phenylethylamino)propylidene]-1,3-diazinane-2,4,6-trione
0
1-cyclohexyl-5-[1-[[2-(3-pyridinyl)-1-piperidinyl]amino]ethylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione
0
1-phenyl-5-[1-(phenylhydrazo)propylidene]-1,3-diazinane-2,4,6-trione
0
1-prop-2-enyl-5-[1-(3-pyridinylmethylamino)ethylidene]-1,3-diazinane-2,4,6-trione
0
1-tert-butyl-5-[(4-ethoxyanilino)methylidene]-1,3-diazinane-2,4,6-trione
0
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(2-hydroxyethyl)-5-phenyl-
0
2-[(4,6-dioxo-2-sulfanylidene-1,3-diazinan-5-yl)methylideneamino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid ethyl ester
0
2-[(4,6-dioxo-2-sulfanylidene-1,3-diazinan-5-ylidene)methylamino]-5-ethyl-3-thiophenecarboxylic acid ethyl ester
0
2-[2,5-dimethyl-3-[(2,4,6-trioxo-1,3-diazinan-5-ylidene)methyl]-1-pyrrolyl]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid ethyl ester
0
2-thiobarbituric acid +
20
3-hydroxyhexobarbital
0
4-Hydroxyphenobarbital
0
5,5-diethylbarbituric acid
4
5-(1-acetyl-5-phenyl-3-pyrazolidinylidene)-1,3-dimethyl-1,3-diazinane-2,4,6-trione
0
5-(2-ethoxyethyl)-5-[4-(4-fluorophenoxy)phenoxy]barbituric acid
0
5-(3-anilinoprop-2-enylidene)-1-prop-2-enyl-1,3-diazinane-2,4,6-trione
0
5-(3-methylbutyl)-5-(2-pyridin-4-ylethyl)-1,3-diazinane-2,4,6-trione
0
5-(Butan-2-yl)-1,3-dimethyl-5-(prop-2-en-1-yl)-1,3-diazinane-2,4,6-trione
0
5-(thiophen-2-ylmethyl)-1,3-diazinane-2,4,6-trione
0
5-[(1-cyclohexyl-2,5-dimethyl-3-pyrrolyl)methylidene]-1-methyl-2-sulfanylidene-1,3-diazinane-4,6-dione
0
5-[(2-phenyl-5-pyrimidinyl)methylidene]-1-(4-propan-2-ylphenyl)-1,3-diazinane-2,4,6-trione
0
5-[(3-hydroxypropylamino)methylidene]-1-(phenylmethyl)-1,3-diazinane-2,4,6-trione
0
5-[(3-methylanilino)methylidene]-1-(2-methylphenyl)-1,3-diazinane-2,4,6-trione
0
5-[(4-methoxy-2-methylanilino)methylidene]-1-prop-2-enyl-1,3-diazinane-2,4,6-trione
0
5-[(4-methoxy-3-methylphenyl)methylidene]-1-methyl-2-sulfanylidene-1,3-diazinane-4,6-dione
0
5-[1-[3-(4-ethylphenoxy)propylamino]ethylidene]-1,3-dimethyl-1,3-diazinane-2,4,6-trione
0
5-[1-[4-(diethylamino)anilino]propylidene]-1-prop-2-enyl-1,3-diazinane-2,4,6-trione
0
5-[2-methyl-1-(phenylmethyl)-6-(trifluoromethyl)-4-pyridinylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione
0
5-[[(4-methylphenyl)hydrazo]methylidene]-1-phenyl-1,3-diazinane-2,4,6-trione
0
5-[[2-(methylthio)-5-pyrimidinyl]methylidene]-1-(4-propan-2-ylphenyl)-1,3-diazinane-2,4,6-trione
0
5-[[4-(4-morpholinylmethyl)anilino]methylidene]-1-(phenylmethyl)-1,3-diazinane-2,4,6-trione
0
5-[[4-(diethylamino)-2-methoxyphenyl]methylidene]-1-ethyl-2-sulfanylidene-1,3-diazinane-4,6-dione
0
5-[[4-(diethylamino)anilino]methylidene]-1-(2-furanylmethyl)-1,3-diazinane-2,4,6-trione
0
5-[[4-(diethylamino)anilino]methylidene]-1-(2-methylphenyl)-1,3-diazinane-2,4,6-trione
0
5-[[4-(diethylamino)anilino]methylidene]-1-(phenylmethyl)-1,3-diazinane-2,4,6-trione
0
5-[[5-(diethylamino)-2-furanyl]methylidene]-1,3-dimethyl-2-sulfanylidene-1,3-diazinane-4,6-dione
0
5-butyl-1-cyclohexylbarbituric acid
1
5-methyl-5-(4-phenoxyphenyl)barbituric acid
0
5-methylbarbituric acid
0
Butabarbital sodium
0
DMP-PYT
0
Epoxy-hexobarbital
0
Heptabarbital
0
MP-PYT
0
Methitural
0
N'-[(1,3-dimethyl-4,6-dioxo-2-sulfanylidene-1,3-diazinan-5-ylidene)methyl]-4-pyridinecarbohydrazide
0
N'-[[1-[(4-methoxyphenyl)methyl]-2,4,6-trioxo-1,3-diazinan-5-ylidene]methyl]benzohydrazide
0
N'-[[1-[2-(4-fluorophenyl)ethyl]-2,4,6-trioxo-1,3-diazinan-5-ylidene]methyl]-4-pyridinecarbohydrazide
0
N'-[[2,4,6-trioxo-1-(2,4,6-trimethylphenyl)-1,3-diazinan-5-ylidene]methyl]-4-pyridinecarbohydrazide
0
Narcobarbital
0
allobarbital
0
amobarbital
3
aprobarbital
0
barbiturate anion +
0
barbituric acid +
68
brallobarbital
0
butabarbital
0
butalbital
0
buthalital
0
butobarbital
0
carbubarb
0
cyclobarbital
1
cyclopentobarbital
0
daprodustat
0
dialuric acid
0
difebarbamate
0
enallylpropymal
0
etallobarbital
0
eterobarb
0
febarbamate
0
heptobarbital
0
hexobarbital
3
mephobarbital
2
methallatal
0
methohexital
5
nealbarbital
0
pentobarbital
112
phenallymal
0
phenobarbital +
4542
phenobarbital sodium
0
phetharbital
0
propallylonal
0
proxibarbal
0
reposal
0
secobarbital
8
talbutal
0
tetrabarbital
0
thialbarbital
0
thiamylal
5
thiopental
20
vinbarbital
0
vinylbital
0
Path 2
CHEBI ontology
19880
subatomic particle
19878
composite particle
19878
hadron
19878
baryon
19878
nucleon
19878
atomic nucleus
19878
atom
19878
main group element atom
19817
p-block element atom
19817
carbon group element atom
19757
carbon atom
19754
organic molecular entity
19754
organic molecule
19706
organic cyclic compound
19495
organic heterocyclic compound
18874
organic heteromonocyclic compound
17795
diazines
13216
pyrimidines
13086
pyrimidone
10512
barbiturates
4626
1,3-dimethyl-5-[1-(1-phenylethylamino)propylidene]-1,3-diazinane-2,4,6-trione
0
1-(3,4-dimethylphenyl)-5-[[(4-methoxyphenyl)hydrazo]methylidene]-1,3-diazinane-2,4,6-trione
0
1-(3-bromophenyl)-5-(3-thiophenylmethylidene)-1,3-diazinane-2,4,6-trione
0
1-(3-chloropropyl)-5-[[(2-chloro-3-pyridinyl)amino]methylidene]-3-cyclohexyl-1,3-diazinane-2,4,6-trione
0
1-(3-methoxyphenyl)-5-[(5-nitro-2-thiophenyl)methylidene]-1,3-diazinane-2,4,6-trione
0
1-(4-bromophenyl)-5-[(1,2,5-trimethyl-3-pyrrolyl)methylidene]-1,3-diazinane-2,4,6-trione
0
1-(4-chlorophenyl)-5-[(1,2,5-trimethyl-3-pyrrolyl)methylidene]-1,3-diazinane-2,4,6-trione
0
1-(4-chlorophenyl)-5-[1-(2-oxolanylmethylamino)ethylidene]-1,3-diazinane-2,4,6-trione
0
1-[(2-chlorophenyl)methyl]-5-[(5-methyl-2-furanyl)methylidene]-1,3-diazinane-2,4,6-trione
0
1-[(4-fluorophenyl)methyl]-5-(thiophen-2-ylmethylidene)-1,3-diazinane-2,4,6-trione
0
1-[1-(1,3-dimethyl-2,4,6-trioxo-1,3-diazinan-5-ylidene)ethylamino]-3-phenylthiourea
0
1-[2-(1-cyclohexenyl)ethyl]-5-[[4-(diethylamino)anilino]methylidene]-1,3-diazinane-2,4,6-trione
0
1-butyl-5-[1-(2-phenylethylamino)propylidene]-1,3-diazinane-2,4,6-trione
0
1-cyclohexyl-5-[1-[[2-(3-pyridinyl)-1-piperidinyl]amino]ethylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione
0
1-phenyl-5-[1-(phenylhydrazo)propylidene]-1,3-diazinane-2,4,6-trione
0
1-prop-2-enyl-5-[1-(3-pyridinylmethylamino)ethylidene]-1,3-diazinane-2,4,6-trione
0
1-tert-butyl-5-[(4-ethoxyanilino)methylidene]-1,3-diazinane-2,4,6-trione
0
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(2-hydroxyethyl)-5-phenyl-
0
2-[(4,6-dioxo-2-sulfanylidene-1,3-diazinan-5-yl)methylideneamino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid ethyl ester
0
2-[(4,6-dioxo-2-sulfanylidene-1,3-diazinan-5-ylidene)methylamino]-5-ethyl-3-thiophenecarboxylic acid ethyl ester
0
2-[2,5-dimethyl-3-[(2,4,6-trioxo-1,3-diazinan-5-ylidene)methyl]-1-pyrrolyl]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid ethyl ester
0
2-thiobarbituric acid +
20
3-hydroxyhexobarbital
0
4-Hydroxyphenobarbital
0
5,5-diethylbarbituric acid
4
5-(1-acetyl-5-phenyl-3-pyrazolidinylidene)-1,3-dimethyl-1,3-diazinane-2,4,6-trione
0
5-(2-ethoxyethyl)-5-[4-(4-fluorophenoxy)phenoxy]barbituric acid
0
5-(3-anilinoprop-2-enylidene)-1-prop-2-enyl-1,3-diazinane-2,4,6-trione
0
5-(3-methylbutyl)-5-(2-pyridin-4-ylethyl)-1,3-diazinane-2,4,6-trione
0
5-(Butan-2-yl)-1,3-dimethyl-5-(prop-2-en-1-yl)-1,3-diazinane-2,4,6-trione
0
5-(thiophen-2-ylmethyl)-1,3-diazinane-2,4,6-trione
0
5-[(1-cyclohexyl-2,5-dimethyl-3-pyrrolyl)methylidene]-1-methyl-2-sulfanylidene-1,3-diazinane-4,6-dione
0
5-[(2-phenyl-5-pyrimidinyl)methylidene]-1-(4-propan-2-ylphenyl)-1,3-diazinane-2,4,6-trione
0
5-[(3-hydroxypropylamino)methylidene]-1-(phenylmethyl)-1,3-diazinane-2,4,6-trione
0
5-[(3-methylanilino)methylidene]-1-(2-methylphenyl)-1,3-diazinane-2,4,6-trione
0
5-[(4-methoxy-2-methylanilino)methylidene]-1-prop-2-enyl-1,3-diazinane-2,4,6-trione
0
5-[(4-methoxy-3-methylphenyl)methylidene]-1-methyl-2-sulfanylidene-1,3-diazinane-4,6-dione
0
5-[1-[3-(4-ethylphenoxy)propylamino]ethylidene]-1,3-dimethyl-1,3-diazinane-2,4,6-trione
0
5-[1-[4-(diethylamino)anilino]propylidene]-1-prop-2-enyl-1,3-diazinane-2,4,6-trione
0
5-[2-methyl-1-(phenylmethyl)-6-(trifluoromethyl)-4-pyridinylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione
0
5-[[(4-methylphenyl)hydrazo]methylidene]-1-phenyl-1,3-diazinane-2,4,6-trione
0
5-[[2-(methylthio)-5-pyrimidinyl]methylidene]-1-(4-propan-2-ylphenyl)-1,3-diazinane-2,4,6-trione
0
5-[[4-(4-morpholinylmethyl)anilino]methylidene]-1-(phenylmethyl)-1,3-diazinane-2,4,6-trione
0
5-[[4-(diethylamino)-2-methoxyphenyl]methylidene]-1-ethyl-2-sulfanylidene-1,3-diazinane-4,6-dione
0
5-[[4-(diethylamino)anilino]methylidene]-1-(2-furanylmethyl)-1,3-diazinane-2,4,6-trione
0
5-[[4-(diethylamino)anilino]methylidene]-1-(2-methylphenyl)-1,3-diazinane-2,4,6-trione
0
5-[[4-(diethylamino)anilino]methylidene]-1-(phenylmethyl)-1,3-diazinane-2,4,6-trione
0
5-[[5-(diethylamino)-2-furanyl]methylidene]-1,3-dimethyl-2-sulfanylidene-1,3-diazinane-4,6-dione
0
5-butyl-1-cyclohexylbarbituric acid
1
5-methyl-5-(4-phenoxyphenyl)barbituric acid
0
5-methylbarbituric acid
0
Butabarbital sodium
0
DMP-PYT
0
Epoxy-hexobarbital
0
Heptabarbital
0
MP-PYT
0
Methitural
0
N'-[(1,3-dimethyl-4,6-dioxo-2-sulfanylidene-1,3-diazinan-5-ylidene)methyl]-4-pyridinecarbohydrazide
0
N'-[[1-[(4-methoxyphenyl)methyl]-2,4,6-trioxo-1,3-diazinan-5-ylidene]methyl]benzohydrazide
0
N'-[[1-[2-(4-fluorophenyl)ethyl]-2,4,6-trioxo-1,3-diazinan-5-ylidene]methyl]-4-pyridinecarbohydrazide
0
N'-[[2,4,6-trioxo-1-(2,4,6-trimethylphenyl)-1,3-diazinan-5-ylidene]methyl]-4-pyridinecarbohydrazide
0
Narcobarbital
0
allobarbital
0
amobarbital
3
aprobarbital
0
barbiturate anion +
0
barbituric acid +
68
brallobarbital
0
butabarbital
0
butalbital
0
buthalital
0
butobarbital
0
carbubarb
0
cyclobarbital
1
cyclopentobarbital
0
daprodustat
0
dialuric acid
0
difebarbamate
0
enallylpropymal
0
etallobarbital
0
eterobarb
0
febarbamate
0
heptobarbital
0
hexobarbital
3
mephobarbital
2
methallatal
0
methohexital
5
nealbarbital
0
pentobarbital
112
phenallymal
0
phenobarbital +
4542
phenobarbital sodium
0
phetharbital
0
propallylonal
0
proxibarbal
0
reposal
0
secobarbital
8
talbutal
0
tetrabarbital
0
thialbarbital
0
thiamylal
5
thiopental
20
vinbarbital
0
vinylbital
0