azobenzenes - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	azobenzenes	go back to main search page
Accession:	CHEBI:22682	browse the term
Definition:	Any member of the wide class of molecules that share the core azobenzene structure, comprising two phenyl rings linked by a N=N double bond, which may have different functional groups extending from the rings.

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Rat (262) Mouse (268) Human (259) Chinchilla (0) Bonobo (0) Dog (1) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (262)

(E)-azobenzene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

nuclear receptor subfamily 1, group I, member 3

increases activity

azobenzene results in increased activity of NR1I3 protein

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

3-[(4-anilinophenyl)diazenyl]benzene-1-sulfonic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catalase

decreases activity

metanil yellow results in decreased activity of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin B1

multiple interactions

[Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CCNB1 mRNA; [Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CCNB1 protein

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin D1

increases expression
multiple interactions

metanil yellow results in increased expression of CCND1 protein
[Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CCND1 mRNA; [Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CCND1 protein; metanil yellow promotes the reaction [Diethylnitrosamine results in increased expression of CCND1 protein]

PMID:10906429 PMID:12616621

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin E1

multiple interactions
increases expression

metanil yellow promotes the reaction [Diethylnitrosamine results in increased expression of CCNE1 protein]
metanil yellow results in increased expression of CCNE1 protein

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cyclin-dependent kinase 1

multiple interactions

[Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CDK1 mRNA; [Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CDK1 protein

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase 4

multiple interactions

[Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CDK4 mRNA; [Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CDK4 protein

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

follicle stimulating hormone subunit beta

decreases expression

metanil yellow results in decreased expression of FSHB

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

glutathione-disulfide reductase

decreases activity

metanil yellow results in decreased activity of GSR protein

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

luteinizing hormone subunit beta

decreases expression

metanil yellow results in decreased expression of LHB

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

proliferating cell nuclear antigen

multiple interactions
increases expression

[Diethylnitrosamine co-treated with metanil yellow] results in increased expression of PCNA protein; metanil yellow promotes the reaction [Diethylnitrosamine results in increased expression of PCNA protein]
metanil yellow results in increased expression of PCNA protein

PMID:10906429 PMID:11831363 PMID:12616621

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

3-methyl-4'-dimethylaminoazobenzene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

tyrosine aminotransferase

multiple interactions

Methyldimethylaminoazobenzene inhibits the reaction [Dexamethasone results in increased expression of TAT mRNA]; Methyldimethylaminoazobenzene inhibits the reaction [Glucocorticoids results in increased expression of TAT mRNA]; Methyldimethylaminoazobenzene inhibits the reaction [Hydrocortisone results in increased activity of TAT protein]

PMID:12882633 PMID:16267830

NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031

4-(dimethylamino)azobenzene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catalase

decreases activity

p-Dimethylaminoazobenzene results in decreased activity of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

4-Hydroxyazobenzene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

estrogen receptor 1

increases activity

4-hydroxyazobenzene results in increased activity of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

arginine vasopressin

multiple interactions

pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased secretion of AVP protein]

NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425

G

fibronectin 1

decreases expression

pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid results in decreased expression of FN1 mRNA

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

H2A.X variant histone

multiple interactions

pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]]

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

interleukin 6

multiple interactions

pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Silicon Dioxide analog results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

NADPH oxidase 1

multiple interactions

pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [NOX1 protein promotes the reaction [glycylphenylalanine 2-naphthylamide results in increased export of Calcium]]

NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236

G

oxytocin/neurophysin I prepropeptide

multiple interactions

pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of OXT protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased secretion of OXT protein]

NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490

G

purinergic receptor P2X 7

multiple interactions

pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein]
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate binds to and results in increased activity of P2RX7 protein]

PMID:21638035 PMID:31263019

NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619

G

poly (ADP-ribose) polymerase 1

multiple interactions

pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [zinc chloride results in increased expression of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

tumor protein p53 binding protein 1

multiple interactions

pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein]]

NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822

azobenzene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

nuclear receptor subfamily 1, group I, member 3

increases activity

azobenzene results in increased activity of NR1I3 protein

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

olsalazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

olsalazine results in decreased activity of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

ortho-Aminoazotoluene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 2

multiple interactions
increases expression

NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of ABCC2 mRNA]

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 4

multiple interactions
increases expression

NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of ABCC4 mRNA]

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

aryl hydrocarbon receptor

multiple interactions

AHR protein affects the reaction [o-Aminoazotoluene affects the expression of CYP1A1 mRNA]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

BCL2 associated X, apoptosis regulator

increases expression

o-Aminoazotoluene results in increased expression of BAX mRNA

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

cyclin G1

increases expression

o-Aminoazotoluene results in increased expression of CCNG1 mRNA

NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641

G

cyclin-dependent kinase inhibitor 1A

increases expression

o-Aminoazotoluene results in increased expression of CDKN1A mRNA

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression
increases activity

AHR protein affects the reaction [o-Aminoazotoluene affects the expression of CYP1A1 mRNA]
o-Aminoazotoluene results in increased expression of CYP1A1 mRNA
o-Aminoazotoluene results in increased activity of CYP1A1 protein

PMID:10887293 PMID:12700417 PMID:14562683 PMID:15863256

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases activity
increases expression

o-Aminoazotoluene results in increased activity of CYP1A2 protein
o-Aminoazotoluene results in increased expression of CYP1A2 mRNA

PMID:10887293 PMID:14562683 PMID:15863256

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression
multiple interactions

o-Aminoazotoluene results in increased expression of CYP2B10 mRNA; o-Aminoazotoluene results in increased expression of CYP2B10 protein
NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP2B10 protein]

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily C, polypeptide 6

increases expression
multiple interactions

o-Aminoazotoluene results in increased expression of CYP2C29 mRNA
NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP2C29 mRNA]

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

forkhead box A3

decreases activity

o-Aminoazotoluene results in decreased activity of FOXA3 protein

NCBI chr 1:78,662,067...78,672,321
Ensembl chr 1:78,662,431...78,672,155

G

MDM2 proto-oncogene

increases expression

o-Aminoazotoluene results in increased expression of MDM2 mRNA

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions
increases expression

NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of MYC mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of MYC protein]
o-Aminoazotoluene results in increased expression of MYC mRNA; o-Aminoazotoluene results in increased expression of MYC protein

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions
increases activity
increases response to substance

NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of ABCC2 mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of ABCC4 mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP2B10 protein]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP2C29 mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP3A11 mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of MYC mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of MYC protein]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of UGT1A1 mRNA]
o-Aminoazotoluene results in increased activity of NR1I3 protein
NR1I3 protein results in increased susceptibility to o-Aminoazotoluene

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

tyrosine aminotransferase

multiple interactions

o-Aminoazotoluene inhibits the reaction [Dexamethasone results in increased expression of TAT mRNA]; o-Aminoazotoluene inhibits the reaction [Glucocorticoids results in increased expression of TAT mRNA]; o-Aminoazotoluene inhibits the reaction [Hydrocortisone results in increased activity of TAT protein]

PMID:11443928 PMID:12882633 PMID:16267830

NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031

G

tumor protein p53

increases expression

o-Aminoazotoluene results in increased expression of TRP53 mRNA

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

UDP glucuronosyltransferase family 1 member A1

multiple interactions
increases expression

NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of UGT1A1 mRNA]

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

prontosil

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

carbonic anhydrase 2

multiple interactions

sulfamidochrysoidine binds to and results in decreased activity of CA2 protein

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

carbonic anhydrase 3

multiple interactions

sulfamidochrysoidine binds to and results in decreased activity of CA3 protein

NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280

Sudan III

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

affects localization
multiple interactions

sudan III affects the localization of AHR protein
[sudan III affects the localization of AHR protein] promotes the reaction [AHR protein binds to ARNT protein]; [sudan III affects the localization of AHR protein] which results in increased expression of CYP1A1 mRNA; sudan III binds to and results in increased activity of AHR protein
[sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased activity of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] which results in decreased activity of CYP2C11 protein; sudan III binds to and results in increased activity of AHR protein

PMID:15585952 PMID:15788368 PMID:22287322

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions

[sudan III affects the localization of AHR protein] promotes the reaction [AHR protein binds to ARNT protein]

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
increases activity
multiple interactions

sudan III results in increased expression of CYP1A1 mRNA
sudan III results in increased expression of CYP1A1 mRNA; sudan III results in increased expression of CYP1A1 protein
sudan III results in increased activity of CYP1A1 protein
[sudan III affects the localization of AHR protein] which results in increased expression of CYP1A1 mRNA; NR1I3 protein promotes the reaction [sudan III results in increased expression of CYP1A1 mRNA]

PMID:18418879 PMID:20308224 PMID:22287322

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression

sudan III results in increased expression of CYP1A2 protein

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions
decreases expression

[sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 protein]; sudan III results in decreased expression of and results in decreased activity of CYP2B1 protein
sudan III results in decreased expression of CYP2B1 mRNA

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 2

multiple interactions
decreases expression

[sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 protein]; sudan III results in decreased expression of and results in decreased activity of CYP2B2 protein
sudan III results in decreased expression of CYP2B2 mRNA

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, subfamily 2, polypeptide 11

multiple interactions
decreases expression

[sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased activity of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 protein]; [sudan III binds to AHR protein] which results in decreased activity of CYP2C11 protein; sudan III results in decreased expression of and results in decreased activity of CYP2C11 protein
sudan III results in decreased expression of CYP2C11 mRNA

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
decreases expression

[sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 protein]; sudan III results in decreased expression of and results in decreased activity of CYP3A2 protein
sudan III results in decreased expression of CYP3A2 mRNA

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

multiple interactions
decreases expression

[sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 protein]; sudan III results in decreased expression of and results in decreased activity of CYP3A23-3A1 protein
sudan III results in decreased expression of CYP3A23-3A1 mRNA

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450, family 4, subfamily a, polypeptide 1

decreases expression

sudan III results in decreased expression of CYP4A1 mRNA

NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464

G

cytochrome P450, family 4, subfamily a, polypeptide 2

decreases expression

sudan III results in decreased expression of CYP4A2 mRNA

NCBI chr 5:128,922,355...128,934,188
Ensembl chr 5:128,923,615...128,934,165

G

cytochrome P450, family 4, subfamily a, polypeptide 3

decreases expression

sudan III results in decreased expression of CYP4A3 mRNA

NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463

G

NAD(P)H quinone dehydrogenase 1

increases expression

sudan III results in increased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions

NR1I3 protein promotes the reaction [sudan III results in increased expression of CYP1A1 mRNA]

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

peroxisome proliferator activated receptor alpha

decreases expression
multiple interactions

sudan III results in decreased expression of PPARA protein
sudan III results in decreased expression of PPARA mRNA
[sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased activity of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 protein]

PMID:15585952 PMID:15788368

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

retinoid X receptor alpha

decreases expression

sudan III results in decreased expression of RXRA protein

NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712

Sudan IV

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

Scarlet Red results in increased expression of CYP1A1 mRNA; Scarlet Red results in increased expression of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

sulfasalazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aminoadipate aminotransferase

increases expression

Sulfasalazine results in increased expression of AADAT mRNA

NCBI chr16:29,509,392...29,544,332
Ensembl chr16:29,509,394...29,544,332

G

ATP binding cassette subfamily C member 2

multiple interactions

[Sulfasalazine results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily G member 2

increases transport
multiple interactions
decreases methylation
affects transport
increases activity

ABCG2 protein results in increased transport of Sulfasalazine
[Sulfasalazine results in decreased methylation of ABCG2 promoter] which results in increased expression of ABCG2 mRNA; Dactinomycin inhibits the reaction [Sulfasalazine results in increased expression of ABCG2 mRNA]; Sulfasalazine inhibits the reaction [[Adenosine Triphosphate co-treated with ABCG2 protein] results in increased uptake of estrone sulfate]; Sulfasalazine promotes the reaction [Cholesterol results in increased activity of ABCG2 protein]; yu ping feng san inhibits the reaction [Sulfasalazine results in increased activity of ABCG2 protein]
ABCG2 gene polymorphism affects the transport of Sulfasalazine

PMID:18167504 PMID:18408567 PMID:20019844 PMID:27475308 PMID:30083819 More...

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

acetyl-Coenzyme A acyltransferase 1B

increases expression

Sulfasalazine results in increased expression of ACAA1B mRNA

NCBI chr 8:118,872,996...118,881,852
Ensembl chr 8:118,872,997...118,881,825

G

angiotensin converting enzyme 2

decreases expression

Sulfasalazine results in decreased expression of ACE2 mRNA

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

acyl-CoA thioesterase 1

increases expression

Sulfasalazine results in increased expression of ACOT1 mRNA

NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163

G

acyl-CoA thioesterase 3

increases expression

Sulfasalazine results in increased expression of ACOT3 mRNA

NCBI chr 6:103,682,518...103,688,735
Ensembl chr 6:103,682,596...103,688,427
Ensembl chr 6:103,682,596...103,688,427

G

acyl-CoA oxidase 1

increases expression

Sulfasalazine results in increased expression of ACOX1 mRNA

NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232

G

actin alpha 2, smooth muscle

multiple interactions

Sulfasalazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

ADRM1 26S proteasome ubiquitin receptor

increases expression

Sulfasalazine results in increased expression of ADRM1 protein

NCBI chr 3:167,265,435...167,270,197
Ensembl chr 3:167,265,296...167,270,195

G

advanced glycosylation end product-specific receptor

multiple interactions

sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Ager protein] in rat colon

RGD

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

G

apoptosis inducing factor, mitochondria associated 1

multiple interactions
affects localization

BCL2 protein inhibits the reaction [Sulfasalazine affects the localization of AIFM1 protein]

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

AKT serine/threonine kinase 1

multiple interactions

Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aldehyde dehydrogenase 1 family, member A1

decreases expression
increases expression

Sulfasalazine results in decreased expression of ALDH1A1 mRNA
Sulfasalazine results in increased expression of ALDH1A1 protein

PMID:15928459 PMID:31830553

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 2 family member

increases expression

Sulfasalazine results in increased expression of ALDH2 protein

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

G

aldehyde dehydrogenase 6 family, member A1

decreases expression

Sulfasalazine results in decreased expression of ALDH6A1 protein

NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656

G

alkaline phosphatase, intestinal

multiple interactions

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of ALPI protein]

NCBI chr 9:87,773,411...87,776,877
Ensembl chr 9:87,773,411...87,776,877

G

annexin A2

increases expression

Sulfasalazine results in increased expression of ANXA2 mRNA

NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658

G

apolipoprotein A4

decreases expression

Sulfasalazine results in decreased expression of APOA4 mRNA

NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469

G

ATP synthase F1 subunit alpha

increases expression

Sulfasalazine results in increased expression of ATP5F1A protein

NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794

G

antizyme inhibitor 1

increases expression

Sulfasalazine results in increased expression of AZIN1 mRNA

NCBI chr 7:69,654,773...69,681,578
Ensembl chr 7:69,654,663...69,681,578

G

BCL2 associated X, apoptosis regulator

affects localization
multiple interactions

Sulfasalazine affects the localization of BAX protein
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX protein]

PMID:12381674 PMID:31428839

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

BCL2 protein inhibits the reaction [Sulfasalazine affects the localization of AIFM1 protein]
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of BCL2 protein]
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid decreases abundance of Bcl-2 protein] in rat colon

CTD
RGD

PMID:12381674 PMID:31428839 PMID:29572553

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

complement C6

decreases expression

Sulfasalazine results in decreased expression of C6 mRNA

NCBI chr 2:53,846,028...53,921,279
Ensembl chr 2:53,851,985...53,921,275

G

calreticulin

decreases expression

Sulfasalazine results in decreased expression of CALR protein

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

caspase 1

multiple interactions

Sulfasalazine inhibits the reaction [Acetic Acid results in increased cleavage of CASP1 protein]; Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of CASP1 protein]

PMID:30408459 PMID:35595039

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

multiple interactions
increases activity

Sulfasalazine inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]; Sulfasalazine results in increased cleavage of and results in increased activity of CASP3 protein
Sulfasalazine results in increased activity of CASP3 protein
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of CASP3 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CASP3 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased activity of CASP3 protein]

PMID:12381674 PMID:16322111 PMID:17051331 PMID:19473188 PMID:19859796 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

multiple interactions
increases cleavage

Sulfasalazine inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP9 protein]
Sulfasalazine results in increased cleavage of CASP9 protein

PMID:16322111 PMID:19859796

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

increases activity
multiple interactions
decreases activity

Sulfasalazine results in increased activity of CAT protein
Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased activity of CAT protein]
Sulfasalazine results in decreased activity of CAT protein

PMID:19028562 PMID:19071188 PMID:28421826

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

multiple interactions

4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CAV1 mRNA]; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CAV1 mRNA

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

carbonyl reductase 1

decreases expression

Sulfasalazine results in decreased expression of CBR1 protein

NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393

G

C-C motif chemokine ligand 2

multiple interactions

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CCL2 mRNA]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cyclin D1

multiple interactions
decreases expression

[[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein] which results in decreased expression of CCND1 mRNA
Sulfasalazine results in decreased expression of CCND1 mRNA

PMID:17202759 PMID:19015640

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin G1

increases expression

Sulfasalazine results in increased expression of CCNG1 mRNA

NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641

G

CD14 molecule

multiple interactions

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD14 mRNA

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

G

CD19 molecule

multiple interactions

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD19 mRNA

NCBI chr 1:180,987,286...180,993,920
Ensembl chr 1:180,987,286...180,993,975

G

CD27 molecule

multiple interactions

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD27 mRNA

NCBI chr 4:158,030,700...158,035,862
Ensembl chr 4:158,030,703...158,035,592

G

CD38 molecule

multiple interactions

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD38 mRNA

NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986

G

CD3 delta subunit of T-cell receptor complex

multiple interactions

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD3D mRNA

NCBI chr 8:45,287,803...45,293,342
Ensembl chr 8:45,288,749...45,301,809

G

CD46 molecule

decreases expression

Sulfasalazine results in decreased expression of CD46 mRNA

NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445

G

CD55 molecule (Cromer blood group)

decreases expression

Sulfasalazine results in decreased expression of CD55 mRNA

PMID:15625186 PMID:17166698

NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831

G

CD59b molecule

decreases expression

Sulfasalazine results in decreased expression of CD59 mRNA; Sulfasalazine results in decreased expression of CD59 protein

PMID:15625186 PMID:17166698

NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847

G

CD74 molecule

multiple interactions

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD74 mRNA

NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003

G

cadherin 1

multiple interactions

4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA]; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

protoporphyrin IX inhibits the reaction [[Sulfasalazine results in increased expression of HMOX1 protein] which results in increased expression of CDKN1A protein]

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

claudin 2

multiple interactions

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CLDN2 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CLDN2 protein]

NCBI chr X:103,459,870...103,473,794
Ensembl chr X:103,459,780...103,474,838

G

clusterin

increases expression

Sulfasalazine results in increased expression of CLU mRNA

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

collagen type I alpha 1 chain

multiple interactions

Sulfasalazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

colony stimulating factor 2

multiple interactions

Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of CSF2 protein]

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

cytotoxic T-lymphocyte-associated protein 4

multiple interactions

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CTLA4 mRNA

NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963

G

catenin beta 1

multiple interactions

[[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein] which results in decreased expression of CCND1 mRNA; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CTNNB1 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CTNNB1 protein]

PMID:19015640 PMID:26165751

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

C-X-C motif chemokine ligand 1

multiple interactions
affects secretion

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CXCL1 mRNA; IL1B protein affects the reaction [Sulfasalazine affects the secretion of CXCL1 protein]

PMID:12231210 PMID:28863153

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 3

affects secretion
multiple interactions

Sulfasalazine affects the secretion of CXCL1 protein
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CXCL1 mRNA; IL1B protein affects the reaction [Sulfasalazine affects the secretion of CXCL1 protein]

PMID:12231210 PMID:28863153

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

Sulfasalazine results in increased expression of CYP1A1 mRNA

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 27, subfamily b, polypeptide 1

decreases expression

Sulfasalazine results in decreased expression of CYP27B1 mRNA

NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression

Sulfasalazine results in increased expression of CYP2B10 mRNA

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily c, polypeptide 24

increases expression

Sulfasalazine results in increased expression of CYP2C55 mRNA; Sulfasalazine results in increased expression of CYP2C55 protein

NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238

G

cytochrome P450, family 2, subfamily C, polypeptide 6

increases expression

Sulfasalazine results in increased expression of CYP2C29 mRNA

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

DNA-damage inducible transcript 3

increases expression

Sulfasalazine results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

iodothyronine deiodinase 1

multiple interactions

[Sulfasalazine co-treated with pyrazolanthrone] inhibits the reaction [IL1B protein results in decreased expression of DIO1 mRNA]

NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970

G

iodothyronine deiodinase 2

multiple interactions

Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of DIO2 protein]; Sulfasalazine inhibits the reaction [RELA protein promotes the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA]]
Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of DIO2 protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA]

PMID:16728495 PMID:21068073

NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809

G

DnaJ heat shock protein family (Hsp40) member A2

increases expression

Sulfasalazine results in increased expression of DNAJA2 mRNA

NCBI chr19:21,497,792...21,516,904
Ensembl chr19:21,497,729...21,516,901

G

epidermal growth factor

increases expression

Sulfasalazine results in increased expression of EGF mRNA

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

multiple interactions
decreases expression

[Sulfasalazine co-treated with celastrol] affects the expression of EGFR protein; [Sulfasalazine co-treated with celastrol] results in decreased expression of EGFR protein; geldanamycin promotes the reaction [Sulfasalazine results in decreased expression of EGFR protein]
Sulfasalazine results in decreased expression of EGFR mRNA; Sulfasalazine results in decreased expression of EGFR protein

PMID:20007406 PMID:31830553

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

early growth response 1

decreases expression

Sulfasalazine results in decreased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

epoxide hydrolase 1

increases expression

Sulfasalazine results in increased expression of EPHX1 mRNA

PMID:22016648 PMID:31830553

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

coagulation factor III, tissue factor

multiple interactions

Sulfasalazine inhibits the reaction [Heme results in increased expression of F3 mRNA]

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

fatty acid binding protein 4

increases expression

Sulfasalazine results in increased expression of FABP4 mRNA

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

fibrinogen alpha chain

increases expression

Sulfasalazine results in increased expression of FGA mRNA

NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528

G

fumarate hydratase

decreases expression

Sulfasalazine results in decreased expression of FH protein

NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266

G

formation of mitochondrial complex V assembly factor 1

decreases expression

Sulfasalazine results in decreased expression of FMC1 mRNA

NCBI chr 4:67,274,104...67,282,140
Ensembl chr 4:67,274,104...67,282,140

G

follicle stimulating hormone subunit beta

multiple interactions

Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased expression of FSHB protein]

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

ferritin light chain 1

increases expression

Sulfasalazine results in increased expression of FTL1 mRNA

NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725
Ensembl chr 2:95,936,387...95,939,725

G

G0/G1switch 2

increases expression

Sulfasalazine results in increased expression of G0S2 mRNA

NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451

G

growth arrest and DNA-damage-inducible, beta

decreases expression

Sulfasalazine results in decreased expression of GADD45B mRNA

NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046

G

glyceraldehyde-3-phosphate dehydrogenase

decreases expression

Sulfasalazine results in decreased expression of GAPDH protein

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

glial cell derived neurotrophic factor

multiple interactions

Sulfasalazine inhibits the reaction [rasagiline results in increased expression of GDNF protein]

NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209

G

glutamic--pyruvic transaminase

increases expression

Sulfasalazine results in increased expression of GPT protein

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 3

decreases expression

Sulfasalazine results in decreased expression of GPX3 mRNA

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

G

glycogen synthase kinase 3 beta

multiple interactions

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GSK3B protein]

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

glutathione-disulfide reductase

decreases activity

Sulfasalazine results in decreased activity of GSR protein

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase alpha 2

increases expression

Sulfasalazine results in increased expression of GSTA2 mRNA

NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798

G

glutathione S-transferase alpha 5

increases expression

Sulfasalazine results in increased expression of GSTA5 mRNA
Sulfasalazine results in increased expression of GSTA1 mRNA

PMID:17202759 PMID:31830553

NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472

G

glutathione S-transferase mu 1

decreases expression

Sulfasalazine results in decreased expression of GSTM1 protein

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase mu 2

increases expression

Sulfasalazine results in increased expression of GSTM2 mRNA

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase, mu 5

increases expression

Sulfasalazine results in increased expression of GSTM3 mRNA

NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553

G

glutathione S-transferase pi 1

decreases expression

Sulfasalazine results in decreased expression of GSTP1 mRNA

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

hepatocyte growth factor

multiple interactions

Sulfasalazine inhibits the reaction [HGF protein results in increased expression of MMP9 mRNA]

NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
increases activity

Sulfasalazine inhibits the reaction [TNF protein results in increased expression of HIF1A protein]
Sulfasalazine results in increased activity of HIF1A protein

PMID:12808024 PMID:19502547

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

histidine triad nucleotide binding protein 1

increases expression

Sulfasalazine results in increased expression of HINT1 mRNA

NCBI chr10:38,989,516...38,993,259
Ensembl chr 4:92,100,973...92,101,568

G

high mobility group box 1

increases expression
multiple interactions

Sulfasalazine results in increased expression of HMGB1 mRNA
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Hmgb1 protein] in rat colon

CTD
RGD

PMID:16141653 PMID:29572553

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

heme oxygenase 1

increases response to substance
multiple interactions
increases expression

HMOX1 protein results in increased susceptibility to Sulfasalazine
NFE2L2 protein promotes the reaction [Sulfasalazine results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [Sulfasalazine results in increased expression of HMOX1 protein]; protoporphyrin IX inhibits the reaction [[Sulfasalazine results in increased expression of HMOX1 protein] which results in increased expression of CDKN1A protein]; Sulfasalazine promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]
[Sulfasalazine results in increased expression of HMOX1 protein] which results in increased expression of CDKN1A protein; Sulfasalazine results in increased expression of HMOX1 mRNA; Sulfasalazine results in increased expression of HMOX1 protein

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hydroxysteroid (17-beta) dehydrogenase 3

decreases expression

Sulfasalazine results in decreased expression of HSD17B3 mRNA

NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554

G

hydroxysteroid (17-beta) dehydrogenase 4

increases expression

Sulfasalazine results in increased expression of HSD17B4 mRNA

NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

decreases expression

Sulfasalazine results in decreased expression of HSD3B1 mRNA

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

heat shock protein 90 alpha family class B member 1

increases expression

Sulfasalazine results in increased expression of HSP90AB1 mRNA

NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488

G

heat shock protein family A (Hsp70) member 1A

increases expression

Sulfasalazine results in increased expression of HSPA1A mRNA

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 1B

decreases expression

Sulfasalazine results in decreased expression of HSPA1B mRNA

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

heat shock protein family A (Hsp70) member 2

decreases expression

Sulfasalazine results in decreased expression of HSPA2 protein

NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287

G

intercellular adhesion molecule 1

decreases expression
increases expression
multiple interactions

Sulfasalazine results in decreased expression of ICAM1 mRNA; Sulfasalazine results in decreased expression of ICAM1 protein
Sulfasalazine results in increased expression of ICAM1 protein
Sulfasalazine inhibits the reaction [RELA protein binds to ICAM1 promoter]
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ICAM1 protein]
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Icam-1 protein] in rat colon

CTD
RGD

PMID:11264155 PMID:15553846 PMID:17259377 PMID:20823682 PMID:26165751 More...

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta

increases expression

Sulfasalazine results in increased expression of IDH3B mRNA

NCBI chr 3:117,481,845...117,486,909
Ensembl chr 3:117,481,845...117,486,982

G

indoleamine 2,3-dioxygenase 1

multiple interactions

Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of IDO1 mRNA]

NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730

G

interferon gamma

multiple interactions

[Sulfasalazine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA; Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IFNG protein]; Sulfasalazine inhibits the reaction [IFNG protein results in increased activity of TYMP protein]; Sulfasalazine inhibits the reaction [IFNG protein results in increased expression of CXCL8 protein]
Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL12A protein]]; Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein]; Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IFNG protein]

PMID:11529938 PMID:15269287 PMID:17051331 PMID:25231984 PMID:29594315 More...

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor binding protein 3

affects expression

Sulfasalazine affects the expression of IGFBP3 mRNA

NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083

G

inhibitor of nuclear factor kappa B kinase subunit beta

decreases expression

Sulfasalazine results in decreased expression of IKBKB protein

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

interleukin 10

multiple interactions

Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL10 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein]
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL10 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL10 protein]; Sulfasalazine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL10 protein]
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid decreases abundance of IL-10 protein] in rat colon

CTD
RGD

PMID:15604057 PMID:17051331 PMID:25231984 PMID:25727887 PMID:29731490 More...

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 10 receptor subunit alpha

multiple interactions

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of IL10RA mRNA

NCBI chr 8:45,563,009...45,578,041
Ensembl chr 8:45,563,137...45,578,061

G

interleukin 12A

multiple interactions

Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL12A protein]]

NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734

G

interleukin 12B

multiple interactions

Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL12A protein]]; Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein]

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

interleukin 17A

multiple interactions

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL17A protein]

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 18

multiple interactions

Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of IL18 protein]

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 beta

multiple interactions
decreases expression

[Sulfasalazine co-treated with pyrazolanthrone] inhibits the reaction [IL1B protein results in decreased expression of DIO1 mRNA]; IL1B protein affects the reaction [Sulfasalazine affects the secretion of CXCL1 protein]; IL1B protein affects the reaction [Sulfasalazine affects the secretion of CXCL8 protein]; Sulfasalazine inhibits the reaction [IL1B protein results in decreased expression of THRB mRNA]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
IL1B protein inhibits the reaction [[Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased secretion of IL1B protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]; Sulfasalazine promotes the reaction [IL1B protein results in decreased expression of THRA mRNA alternative form]; Sulfasalazine promotes the reaction [IL1B protein results in decreased expression of THRA mRNA]
Sulfasalazine results in decreased expression of IL1B mRNA
[allicin co-treated with Sulfasalazine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; [allicin co-treated with Sulfasalazine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]

PMID:12133438 PMID:12231210 PMID:15604057 PMID:15793857 PMID:15867298 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor type 1

multiple interactions

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1R1 mRNA]

NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937

G

interleukin 1 receptor antagonist

multiple interactions

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1RN mRNA]

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 2

multiple interactions

[Sulfasalazine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA; Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL2 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased expression of IL2 protein]

PMID:17051331 PMID:29594315 PMID:32272095

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 2 receptor subunit alpha

multiple interactions

Sulfasalazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2RA protein]

NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697

G

interleukin 4

multiple interactions

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased secretion of IL4 protein]

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions

Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL6 protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of and results in increased secretion of IL6 protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased secretion of IL6 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; Sulfasalazine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]

PMID:12135912 PMID:17051331 PMID:19956958 PMID:20884048 PMID:21070844 More...

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin receptor

increases expression

Sulfasalazine results in increased expression of INSR protein

NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883

G

interferon regulatory factor 4

multiple interactions

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of IRF4 mRNA

NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070

G

insulin receptor substrate 2

decreases expression

Sulfasalazine results in decreased expression of IRS2 mRNA

NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482

G

integrin subunit alpha M

multiple interactions

Sulfasalazine inhibits the reaction [TNF protein results in increased expression of ITGAM protein]

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

integrin subunit beta 2

multiple interactions

Sulfasalazine inhibits the reaction [TNF protein results in increased expression of ITGB2 protein]

NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600

G

IL2-inducible T-cell kinase

multiple interactions

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of ITK mRNA

NCBI chr10:30,753,344...30,814,685
Ensembl chr10:30,753,344...30,814,685

G

Janus kinase 2

multiple interactions

Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of JAK2 protein]

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

joining chain of multimeric IgA and IgM

multiple interactions

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of JCHAIN mRNA

NCBI chr14:19,538,927...19,547,023
Ensembl chr14:19,538,952...19,546,298

G

LCK proto-oncogene, Src family tyrosine kinase

multiple interactions

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of LCK mRNA

NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794

G

lactate dehydrogenase C

multiple interactions
increases activity

Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased activity of LDHC protein]
Sulfasalazine results in increased activity of LDHC protein

NCBI chr 1:97,385,984...97,403,382
Ensembl chr 1:97,382,379...97,403,378

G

luteinizing hormone subunit beta

multiple interactions

Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased expression of LHB protein]

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

LSM10, U7 small nuclear RNA associated

decreases expression

Sulfasalazine results in decreased expression of LSM10 mRNA

NCBI chr 5:138,365,983...138,375,856
Ensembl chr 5:138,373,119...138,377,505

G

mitogen activated protein kinase 1

multiple interactions

Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 9

increases phosphorylation

Sulfasalazine results in increased phosphorylation of MAPK9 protein

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

MHC I like leukocyte 1

decreases expression

Sulfasalazine results in decreased expression of MICA mRNA; Sulfasalazine results in decreased expression of MICA protein

NCBI chr 1:78,372,798...78,398,932
Ensembl chr 1:78,372,802...78,398,930

G

microRNA 223

multiple interactions

Sulfasalazine inhibits the reaction [Acetic Acid results in decreased expression of MIR223 mRNA]

NCBI chr X:61,141,887...61,141,996
Ensembl chr X:61,141,887...61,141,996

G

matrix metallopeptidase 1

multiple interactions

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of MMP1 mRNA

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 2

multiple interactions

Sulfasalazine promotes the reaction [Carbon Tetrachloride results in increased activity of MMP2 protein]

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions

Sulfasalazine inhibits the reaction [HGF protein results in increased expression of MMP9 mRNA]; Sulfasalazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of and results in increased cleavage of MMP9 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of MMP9 protein]

PMID:12745093 PMID:22119283 PMID:30972795

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

multiple interactions
decreases activity

Sulfasalazine inhibits the reaction [Acetic Acid results in increased activity of MPO protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; Sulfasalazine inhibits the reaction [Dinitrochlorobenzene results in decreased activity of MPO protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MPO protein]
Sulfasalazine results in decreased activity of MPO protein
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of MPO protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases myeloperoxidase enzyme activity] in rat colon

CTD
RGD

PMID:17373747 PMID:20380826 PMID:22119283 PMID:23665423 PMID:25231984 More...

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

major histocompatibility complex, class I-related

affects expression

Sulfasalazine affects the expression of MR1 mRNA

NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970

G

membrane spanning 4-domains A1

multiple interactions

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of MS4A1 mRNA

NCBI chr 1:207,906,370...207,927,028
Ensembl chr 1:207,906,374...207,918,512

G

methylenetetrahydrofolate reductase

increases response to substance

MTHFR gene polymorphism results in increased susceptibility to Sulfasalazine; MTHFR protein results in increased susceptibility to Sulfasalazine

NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797

G

mucin 17, cell surface associated

multiple interactions

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MUC3 mRNA]

NCBI chr12:19,527,251...19,536,924
Ensembl chr12:19,527,321...19,538,522

G

mucin 2, oligomeric mucus/gel-forming

multiple interactions

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MUC2 mRNA]

NCBI chr 1:196,799,494...196,831,740
Ensembl chr 1:196,799,517...196,831,756

G

mucin 4, cell surface associated

multiple interactions

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MUC4 mRNA]

NCBI chr11:68,008,245...68,053,242

G

MYD88, innate immune signal transduction adaptor

multiple interactions

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MYD88 protein]

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

N-acetyltransferase 2

affects metabolic processing
affects response to substance
increases metabolic processing
increases acetylation

NAT2 gene polymorphism affects the metabolism of Sulfasalazine; NAT2 protein affects the metabolism of Sulfasalazine; NAT2 protein polymorphism affects the metabolism of Sulfasalazine
NAT2 protein affects the susceptibility to Sulfasalazine
NAT2 protein results in increased metabolism of Sulfasalazine
NAT2 protein results in increased acetylation of Sulfasalazine

PMID:12465141 PMID:15032315 PMID:17377643 PMID:17502830 PMID:19560446

NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520

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nucleolin

decreases expression

Sulfasalazine results in decreased expression of NCL protein

NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136

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NFE2 like bZIP transcription factor 2

multiple interactions

[Sulfasalazine results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased localization of NFE2L2 protein; Acetylcysteine inhibits the reaction [[Sulfasalazine results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased localization of NFE2L2 protein]
NFE2L2 protein promotes the reaction [Sulfasalazine results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [Sulfasalazine results in increased expression of HMOX1 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of NFE2L2 mRNA]; Sulfasalazine promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]

PMID:19234301 PMID:31428839

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

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nuclear factor kappa B subunit 1

multiple interactions
decreases expression
decreases localization

Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]
Sulfasalazine results in decreased expression of NFKB1 protein
Sulfasalazine results in decreased localization of NFKB1 protein
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NFKB1 protein]

PMID:9486988 PMID:12135912 PMID:15269287 PMID:17259377 PMID:26165751

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

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NFKB inhibitor alpha

multiple interactions
decreases expression
decreases phosphorylation
increases degradation

Sulfasalazine inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
Sulfasalazine results in decreased expression of NFKBIA protein
Sulfasalazine results in decreased phosphorylation of NFKBIA protein
Sulfasalazine results in increased degradation of NFKBIA protein
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of NFKBIA protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of NFKBIA protein]; Sulfasalazine inhibits the reaction [Glucose results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased degradation of NFKBIA protein]

PMID:9486988 PMID:11786414 PMID:15494508 PMID:15793857 PMID:16934226 More...

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

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NLR family, pyrin domain containing 3

multiple interactions

Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of NLRP3 mRNA]; Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of NLRP3 protein]

PMID:30408459 PMID:35595039

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

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nitric oxide synthase 2

multiple interactions
decreases expression

Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
Sulfasalazine affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Gentamicins results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of NOS2 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein]
Sulfasalazine results in decreased expression of NOS2 mRNA

PMID:11529938 PMID:15867298 PMID:16925772 PMID:16934226 PMID:17259377 More...

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

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NAD(P)H quinone dehydrogenase 1

increases expression

Sulfasalazine results in increased expression of NQO1 mRNA

PMID:19234301 PMID:22016648

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

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nuclear receptor subfamily 3, group C, member 1

increases expression

Sulfasalazine results in increased expression of NR3C1 mRNA; Sulfasalazine results in increased expression of NR3C1 protein

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

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NSFL1 cofactor

increases expression

Sulfasalazine results in increased expression of NSFL1C protein

NCBI chr 3:139,978,306...140,002,876
Ensembl chr 3:139,978,301...140,002,870

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ornithine aminotransferase

increases expression

Sulfasalazine results in increased expression of OAT mRNA

NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682

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occludin

multiple interactions

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of OCLN mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of OCLN protein]

NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150

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ornithine decarboxylase 1

increases expression

Sulfasalazine results in increased expression of ODC1 mRNA

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

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opioid receptor, mu 1

multiple interactions

Sulfasalazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of OPRM1 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of OPRM1 mRNA]

NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409

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proliferating cell nuclear antigen

increases expression

Sulfasalazine results in increased expression of PCNA mRNA

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

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phosphatidylethanolamine binding protein 1

decreases expression

Sulfasalazine results in decreased expression of PEBP1 protein

NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862

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phosphoglycerate mutase 2

increases expression

Sulfasalazine results in increased expression of PGAM2 mRNA

NCBI chr14:80,681,796...80,683,907
Ensembl chr14:80,681,776...80,683,940

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phospholipase A2 group IB

multiple interactions

Sulfasalazine inhibits the reaction [PLA2G1B protein results in increased expression of CXCL8 protein]

NCBI chr12:41,142,193...41,151,967
Ensembl chr12:41,142,200...41,153,226

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peroxisome proliferator-activated receptor gamma

increases expression
multiple interactions

Sulfasalazine results in increased expression of PPARG mRNA
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of PPARG mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of PPARG protein]

PMID:19365232 PMID:26165751 PMID:31830553

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

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PR/SET domain 1

multiple interactions

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of PRDM1 mRNA

NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488

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peroxiredoxin 1

increases expression

Sulfasalazine results in increased expression of PRDX1 mRNA

PMID:16141653 PMID:22016648

NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856

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peroxiredoxin 3

increases expression

Sulfasalazine results in increased expression of PRDX3 mRNA

NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111

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proteasome 20S subunit alpha 7

decreases expression

Sulfasalazine results in decreased expression of PSMA7 protein

NCBI chr 3:167,137,279...167,143,626
Ensembl chr 3:167,137,263...167,143,672

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proteasome 20S subunit beta 9

decreases expression

Sulfasalazine results in decreased expression of PSMB9 mRNA

NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512

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prostaglandin-endoperoxide synthase 2

decreases expression
multiple interactions

Sulfasalazine results in decreased expression of PTGS2 mRNA
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of PTGS2 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein]
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of PTGS2 protein]

PMID:17259377 PMID:19956958 PMID:25576893 PMID:29187079 PMID:30408459 More...

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

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protein tyrosine phosphatase, mitochondrial 1

increases expression

Sulfasalazine results in increased expression of PTPMT1 mRNA

NCBI chr 3:76,889,922...76,899,427
Ensembl chr 3:76,889,922...76,899,427

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RAS guanyl releasing protein 1

multiple interactions

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of RASGRP1 mRNA

NCBI chr 3:104,168,549...104,230,107
Ensembl chr 3:104,170,013...104,230,056

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retinol binding protein 4

affects expression

Sulfasalazine affects the expression of RBP4 mRNA

NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399

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RELA proto-oncogene, NF-kB subunit

multiple interactions
decreases activity
increases localization
affects localization
decreases localization

Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [rasagiline results in increased localization of and results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [RELA protein promotes the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA]]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased localization of and results in increased activity of RELA protein]; Sulfasalazine results in decreased expression of and results in decreased activity of RELA protein; Sulfasalazine results in decreased phosphorylation of and results in decreased activity of RELA protein
Sulfasalazine results in decreased activity of RELA protein
Sulfasalazine results in increased localization of RELA protein
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of RELA protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of RELA protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of RELA protein]; Sulfasalazine inhibits the reaction [RELA protein binds to ICAM1 promoter]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of RELA protein]
Sulfasalazine affects the localization of RELA protein
Sulfasalazine inhibits the reaction [Acetic Acid results in increased phosphorylation of RELA protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased phosphorylation of RELA protein]; Sulfasalazine inhibits the reaction [Gentamicins results in increased expression of RELA protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RELA mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RELA protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of RELA protein]
Sulfasalazine results in decreased localization of RELA protein
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Nf-Kb protein] in rat colon

CTD
RGD

PMID:9486988 PMID:12135912 PMID:14687604 PMID:15269287 PMID:15564333 More...

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

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regulator of G-protein signaling 16

increases expression

Sulfasalazine results in increased expression of RGS16 mRNA

NCBI chr13:65,887,668...65,892,862
Ensembl chr13:65,887,530...65,892,857

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receptor-interacting serine-threonine kinase 2

multiple interactions

Sulfasalazine inhibits the reaction [TNF protein results in increased expression of RIPK2 mRNA]

NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657

G

ring finger protein 186

decreases expression

Sulfasalazine results in decreased expression of RNF186 mRNA

NCBI chr 5:151,210,492...151,211,716
Ensembl chr 5:151,210,492...151,211,716

G

RT1 class II, locus Bb

affects expression

Sulfasalazine affects the expression of RT1-BB mRNA

NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597

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syndecan 1

multiple interactions

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of SDC1 mRNA

NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264

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selectin E

increases expression

Sulfasalazine results in increased expression of SELE protein

NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741

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serpin family A member 4

decreases expression

Sulfasalazine results in decreased expression of SERPINA4-PS1 mRNA

NCBI chr 6:122,999,970...123,009,083
Ensembl chr 6:122,999,900...123,009,082

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serpin family C member 1

increases expression

Sulfasalazine results in increased expression of SERPINC1 mRNA

NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293

G

salt-inducible kinase 1

decreases expression

Sulfasalazine results in decreased expression of SIK1 mRNA

NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991

G

SLAM family member 7

multiple interactions

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of SLAMF7 mRNA

NCBI chr13:84,135,656...84,154,528
Ensembl chr13:84,136,899...84,154,105

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solute carrier family 22 member 7

decreases expression

Sulfasalazine results in decreased expression of SLC22A7 mRNA

NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921

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solute carrier family 25 member 24

decreases expression

Sulfasalazine results in decreased expression of SLC25A24 mRNA

NCBI chr 2:196,761,076...196,799,236
Ensembl chr 2:196,761,274...196,799,231

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solute carrier family 25 member 5

increases expression

Sulfasalazine results in increased expression of SLC25A6 mRNA

NCBI chr X:116,031,896...116,034,963
Ensembl chr X:116,031,803...116,034,967

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solute carrier family 30 member 1

decreases expression

Sulfasalazine results in decreased expression of SLC30A1 mRNA

NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910

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solute carrier family 3 member 2

multiple interactions

Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine]

NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931

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solute carrier family 46 member 1

multiple interactions
decreases activity

Sulfasalazine inhibits the reaction [SLC46A1 protein results in increased transport of Methotrexate]
Sulfasalazine inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]
Sulfasalazine results in decreased activity of SLC46A1 protein

PMID:17475902 PMID:18174275 PMID:19762432

NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848

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solute carrier family 7 member 11

decreases activity
multiple interactions

Sulfasalazine results in decreased activity of SLC7A11 protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CAV1 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA]; [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased abundance of Glutathione] which results in increased abundance of Reactive Oxygen Species; [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein] which results in decreased expression of CCND1 mRNA; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased abundance of Glutathione; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CAV1 mRNA; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA; Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine]

PMID:19015640 PMID:19576933 PMID:20007406

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

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suppressor of cytokine signaling 2

decreases expression

Sulfasalazine results in decreased expression of SOCS2 mRNA

NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548

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suppressor of cytokine signaling 3

multiple interactions

sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Socs3 protein] in rat colon

RGD

NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787

G

superoxide dismutase 1

increases expression

Sulfasalazine results in increased expression of SOD1 mRNA

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 3

decreases expression

Sulfasalazine results in decreased expression of SOD3 mRNA

NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990

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secreted phosphoprotein 1

increases expression

Sulfasalazine results in increased expression of SPP1 mRNA

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

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serine and arginine rich splicing factor 5

increases expression

Sulfasalazine results in increased expression of SRSF5 protein

NCBI chr 6:100,605,165...100,610,192
Ensembl chr 6:100,605,456...100,610,177

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steroidogenic acute regulatory protein

decreases expression
affects expression

Sulfasalazine results in decreased expression of STAR protein
Sulfasalazine affects the expression of STAR mRNA

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

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signal transducer and activator of transcription 3

multiple interactions

Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of STAT3 protein]

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

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thromboxane A synthase 1

multiple interactions
decreases activity

[Sulfasalazine results in decreased activity of TBXAS1 protein] which results in decreased chemical synthesis of 12-hydroxy-5,8,10-heptadecatrienoic acid; [Sulfasalazine results in decreased activity of TBXAS1 protein] which results in decreased chemical synthesis of Thromboxane B2

NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096

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tryptophan 2,3-dioxygenase

multiple interactions

Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TDO2 mRNA]

NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511

G

trefoil factor 3

multiple interactions

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TFF3 mRNA]

NCBI chr20:9,193,259...9,197,969
Ensembl chr20:9,193,262...9,198,054

G

thyroid hormone receptor alpha

multiple interactions
decreases expression

[Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA; IL1B protein inhibits the reaction [[Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA]; Sulfasalazine promotes the reaction [IL1B protein results in decreased expression of THRA mRNA alternative form]; Sulfasalazine promotes the reaction [IL1B protein results in decreased expression of THRA mRNA]
Sulfasalazine results in decreased expression of THRA mRNA; Sulfasalazine results in decreased expression of THRA mRNA alternative form

NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936

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thyroid hormone receptor beta

multiple interactions

Sulfasalazine inhibits the reaction [IL1B protein results in decreased expression of THRB mRNA]

NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916

G

TIMP metallopeptidase inhibitor 1

multiple interactions

Sulfasalazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein]

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

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TIMP metallopeptidase inhibitor 2

increases expression

Sulfasalazine results in increased expression of TIMP2 mRNA

NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611

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TIMP metallopeptidase inhibitor 3

increases expression

Sulfasalazine results in increased expression of TIMP3 mRNA

NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839

G

tight junction protein 1

multiple interactions

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of TJP1 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of TJP1 protein]

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

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toll-like receptor 2

multiple interactions

Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

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toll-like receptor 4

multiple interactions

Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of TLR4 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TLR4 protein]

PMID:19956958 PMID:32272095

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

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toll-like receptor 9

multiple interactions

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TLR9 protein]

NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796

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tumor necrosis factor

multiple interactions
increases response to substance
decreases expression
decreases secretion

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of TNF mRNA; Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of TYMP protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of HIF1A protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of ITGAM protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of ITGB2 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of OPRM1 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of RIPK2 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased localization of and results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Sulfasalazine promotes the reaction [Ganciclovir results in increased secretion of TNF protein]
Sulfasalazine results in increased susceptibility to TNF protein
[allicin co-treated with Sulfasalazine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; Sulfasalazine binds to and results in decreased activity of TNF protein; Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased secretion of TNF protein]
Sulfasalazine results in decreased expression of TNF mRNA
Sulfasalazine results in decreased secretion of TNF protein
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of and results in increased secretion of TNF protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased secretion of TNF protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Tnfa protein] in rat colon

CTD
RGD

PMID:8094364 PMID:8598465 PMID:9486988 PMID:11901219 PMID:12135912 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 11B

increases secretion

Sulfasalazine results in increased secretion of TNFRSF11B protein

NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538

G

TNF receptor superfamily member 17

multiple interactions

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of TNFRSF17 mRNA

NCBI chr10:4,301,023...4,306,889
Ensembl chr10:4,301,038...4,306,788

G

TNF receptor superfamily member 1A

multiple interactions

Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of TNFRSF1A protein]

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

TNF superfamily member 11

decreases expression

Sulfasalazine results in decreased expression of TNFSF11 mRNA; Sulfasalazine results in decreased expression of TNFSF11 protein

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

tropomyosin 3

decreases expression

Sulfasalazine results in decreased expression of TPM3 mRNA alternative form; Sulfasalazine results in decreased expression of TPM3 protein alternative form

NCBI chr 2:175,517,198...175,545,014
Ensembl chr 2:175,517,226...175,545,013

G

TNF receptor associated factor 6

multiple interactions

Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of TRAF6 protein]

NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507

G

thyroid stimulating hormone subunit beta

increases secretion

Sulfasalazine results in increased secretion of TSHB protein

NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559

G

tubulin, beta 5 class I

increases expression

Sulfasalazine results in increased expression of TUBB5 mRNA

NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940

G

thymidine phosphorylase

multiple interactions
decreases expression

Sulfasalazine inhibits the reaction [IFNG protein results in increased activity of TYMP protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of TYMP protein]; Sulfasalazine results in decreased expression of and results in decreased activity of TYMP protein
Sulfasalazine results in decreased expression of TYMP mRNA

NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874

G

ubiquitin C

increases expression

Sulfasalazine results in increased expression of UBC mRNA

NCBI chr12:31,239,149...31,243,924
Ensembl chr12:31,239,152...31,243,925

G

vascular cell adhesion molecule 1

multiple interactions
decreases expression
increases expression

Sulfasalazine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]
Sulfasalazine results in decreased expression of VCAM1 mRNA; Sulfasalazine results in decreased expression of VCAM1 protein
Sulfasalazine results in increased expression of VCAM1 protein

PMID:11264155 PMID:15553846 PMID:17259377 PMID:19693652

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

vimentin

increases expression

Sulfasalazine results in increased expression of VIM mRNA

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

X-box binding protein 1

multiple interactions

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of XBP1 mRNA

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19874
chemical entity	19872
group	19825
inorganic group	19404
azo group	295
azo compound	295
azobenzenes	262
2,2'-disulfoazobenzene	0
2-[4-(dimethylamino)phenyl]azobenzoic acid [2-(1-azepanyl)-2-oxoethyl] ester	0
3-[(4-anilinophenyl)diazenyl]benzene-1-sulfonic acid	10
3-methyl-4'-dimethylaminoazobenzene	1
4,4'-diaminoazobenzene	0
4,5-dihydroxy-3-(phenyldiazenyl)naphthalene-2,7-disulfonic acid	0
4-(2-hydroxy-5-methylphenylazo)acetanilide	0
4-(4-nitrophenylazo)aniline	0
4-(4-nitrophenylazo)resorcinol	0
4-(dimethylamino)azobenzene	1
4-(phenylazo)aniline	0
4-Hydroxyazobenzene	1
4-[(2,4-Dihydroxyphenyl)azo]benzenesulfonic acid	0
4-[(2,4-dimethylphenyl)diazenyl]-3-hydroxynaphthalene-2,7-disulfonic acid	0
4-[2-(4-chlorophenyl)diaz-1-enyl]-2-methyl-6-(piperidinomethyl)phenol	0
4-[4-[2-(2,4-dioxo-1H-quinolin-3-ylidene)hydrazinyl]-2-methylphenyl]azo-N,N-dimethylbenzamide	0
4-aminoazobenzene-3,4'-disulfonic acid	0
4-carboxy-4'-sulfoazobenzene	0
4-carboxylato-4'-sulfonatoazobenzene	0
4-hydroxy-3-[(2-methoxyphenyl)diazenyl]naphthalene-1-sulfonic acid	0
5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid	9
5-acetamido-4-hydroxy-3-(phenyldiazenyl)naphthalene-2,7-disulfonic acid	0
7-hydroxy-8-[(E)-phenyldiazenyl]naphthalene-1,3-disulfonic acid	0
7-hydroxy-8-\{[4-(phenyldiazenyl)phenyl]diazenyl\}naphthalene-1,3-disulfonic acid	0
Azothoate	0
Biebrich scarlet (acid form)	0
CAY10397	0
CI Pigment Red 3	0
Chrysoidine free base	0
Citrus Red No.2	0
Congo corinth (acid form)	0
Diacetylaminoazotoluene	0
Disperse Red 1	0
Disperse red 17	0
Durazol blue 4R (acid form)	0
Evans blue free acid	0
Milling yellow 3G (free acid)	0
Mordant yellow 12	0
N1,N1-diethyl-4-[2-(4-bromophenyl)diaz-1-enyl]aniline	0
Oil Orange SS	0
Oil red O	0
Olsalazine-O-sulfate	0
Ponceau S (acid form)	0
Pontamine sky blue 5B (acid form)	0
Reactive Red 6 hapten +	0
Reactive Red 6 hapten copper complex	0
Reactive red 120	0
Sirius red 4B (acid form)	0
Sirius red F3B (acid form)	0
Sirius scarlet GG (acid form)	0
Solvent yellow 56	0
Sudan Brown RR	0
Sudan II	0
Sudan III	16
Sudan IV	1
Sudan Red 7B	0
Sudan black B	0
Yellow AB	0
Yellow OB	0
azobenzene +	1
azodopa +	0
basic brown 1 +	0
benzo scarlet 4BNS free acid	0
butanoic acid [2-oxo-2-(4-phenyldiazenylanilino)ethyl] ester	0
diathymosulfone	0
etoxazene	0
lissamine fast red (acid form)	0
lissamine fast yellow (acid form)	0
m-azobenzenesulfonic acid	0
methyl red	0
naphthalene blue black CS (acid form)	0
olsalazine	1
ortho-Aminoazotoluene	17
p-azobenzenesulfonic acid	0
prontosil	2
salazosulfadimidine	0
sulfachrysoidine	0
sulfasalazine	225
trimethyl-[[3-[3-[(trimethylammonio)methyl]phenyl]azophenyl]methyl]ammonium	0
trypan blue sulfonic acid	0
Path 2
Term	Annotations
CHEBI ontology	19874
subatomic particle	19872
composite particle	19872
hadron	19872
baryon	19872
nucleon	19872
atomic nucleus	19872
atom	19872
main group element atom	19811
main group molecular entity	19811
s-block molecular entity	19647
hydrogen molecular entity	19628
hydrides	19139
inorganic hydride	18156
pnictogen hydride	18146
nitrogen hydride	18059
diazene	296
azo group	295
azo compound	295
azobenzenes	262
2,2'-disulfoazobenzene	0
2-[4-(dimethylamino)phenyl]azobenzoic acid [2-(1-azepanyl)-2-oxoethyl] ester	0
3-[(4-anilinophenyl)diazenyl]benzene-1-sulfonic acid	10
3-methyl-4'-dimethylaminoazobenzene	1
4,4'-diaminoazobenzene	0
4,5-dihydroxy-3-(phenyldiazenyl)naphthalene-2,7-disulfonic acid	0
4-(2-hydroxy-5-methylphenylazo)acetanilide	0
4-(4-nitrophenylazo)aniline	0
4-(4-nitrophenylazo)resorcinol	0
4-(dimethylamino)azobenzene	1
4-(phenylazo)aniline	0
4-Hydroxyazobenzene	1
4-[(2,4-Dihydroxyphenyl)azo]benzenesulfonic acid	0
4-[(2,4-dimethylphenyl)diazenyl]-3-hydroxynaphthalene-2,7-disulfonic acid	0
4-[2-(4-chlorophenyl)diaz-1-enyl]-2-methyl-6-(piperidinomethyl)phenol	0
4-[4-[2-(2,4-dioxo-1H-quinolin-3-ylidene)hydrazinyl]-2-methylphenyl]azo-N,N-dimethylbenzamide	0
4-aminoazobenzene-3,4'-disulfonic acid	0
4-carboxy-4'-sulfoazobenzene	0
4-carboxylato-4'-sulfonatoazobenzene	0
4-hydroxy-3-[(2-methoxyphenyl)diazenyl]naphthalene-1-sulfonic acid	0
5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid	9
5-acetamido-4-hydroxy-3-(phenyldiazenyl)naphthalene-2,7-disulfonic acid	0
7-hydroxy-8-[(E)-phenyldiazenyl]naphthalene-1,3-disulfonic acid	0
7-hydroxy-8-\{[4-(phenyldiazenyl)phenyl]diazenyl\}naphthalene-1,3-disulfonic acid	0
Azothoate	0
Biebrich scarlet (acid form)	0
CAY10397	0
CI Pigment Red 3	0
Chrysoidine free base	0
Citrus Red No.2	0
Congo corinth (acid form)	0
Diacetylaminoazotoluene	0
Disperse Red 1	0
Disperse red 17	0
Durazol blue 4R (acid form)	0
Evans blue free acid	0
Milling yellow 3G (free acid)	0
Mordant yellow 12	0
N1,N1-diethyl-4-[2-(4-bromophenyl)diaz-1-enyl]aniline	0
Oil Orange SS	0
Oil red O	0
Olsalazine-O-sulfate	0
Ponceau S (acid form)	0
Pontamine sky blue 5B (acid form)	0
Reactive Red 6 hapten +	0
Reactive Red 6 hapten copper complex	0
Reactive red 120	0
Sirius red 4B (acid form)	0
Sirius red F3B (acid form)	0
Sirius scarlet GG (acid form)	0
Solvent yellow 56	0
Sudan Brown RR	0
Sudan II	0
Sudan III	16
Sudan IV	1
Sudan Red 7B	0
Sudan black B	0
Yellow AB	0
Yellow OB	0
azobenzene +	1
azodopa +	0
basic brown 1 +	0
benzo scarlet 4BNS free acid	0
butanoic acid [2-oxo-2-(4-phenyldiazenylanilino)ethyl] ester	0
diathymosulfone	0
etoxazene	0
lissamine fast red (acid form)	0
lissamine fast yellow (acid form)	0
m-azobenzenesulfonic acid	0
methyl red	0
naphthalene blue black CS (acid form)	0
olsalazine	1
ortho-Aminoazotoluene	17
p-azobenzenesulfonic acid	0
prontosil	2
salazosulfadimidine	0
sulfachrysoidine	0
sulfasalazine	225
trimethyl-[[3-[3-[(trimethylammonio)methyl]phenyl]azophenyl]methyl]ammonium	0
trypan blue sulfonic acid	0

paths to the root