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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-aminofolic acid
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Accession:CHEBI:22526 term browser browse the term
Definition:A dicarboxylic acid that has formula C19H20N8O5.
Synonyms:exact_synonym: N-(4-{[(2,4-diaminopteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
 related_synonym: 4-amino-PGA;   4-aminopteroylglutamic acid;   Formula=C19H20N8O5;   InChI=1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(H4,20,21,23,26,27)/t12-/m0/s1;   InChIKey=TVZGACDUOSZQKY-LBPRGKRZSA-N;   N-(4-(((2,4-diamino-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid;   SMILES=Nc1nc(N)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1;   aminopterin
 xref: Beilstein:69045;   CAS:54-62-6;   Drug_Central:21
 xref_mesh: MESH:D000630
 xref: PMID:18789931


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4-aminofolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tp53 tumor protein p53 affects activity ISO Aminopterin affects the activity of TP53 protein; Aminopterin metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19917
    role 19887
      biological role 19885
        aetiopathogenetic role 19259
          genotoxin 17691
            mutagen 17604
              4-aminofolic acid 1
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Term Annotations click to browse term
  CHEBI ontology 19917
    subatomic particle 19915
      composite particle 19915
        hadron 19915
          baryon 19915
            nucleon 19915
              atomic nucleus 19915
                atom 19915
                  main group element atom 19855
                    main group molecular entity 19855
                      s-block molecular entity 19666
                        hydrogen molecular entity 19668
                          hydrides 19176
                            inorganic hydride 18187
                              pnictogen hydride 18177
                                nitrogen hydride 18090
                                  azane 17896
                                    ammonia 17895
                                      organic amino compound 17895
                                        amino acid 16070
                                          alpha-amino acid 13946
                                            L-alpha-amino acid 12967
                                              glutamine family amino acid 10324
                                                L-glutamic acid 10263
                                                  L-glutamic acid derivative 9418
                                                    folic acids 9418
                                                      folic acid 9399
                                                        4-aminofolic acid 1
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