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G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
increases expression |
ISO |
KRN 7000 results in increased expression of CXCL10 protein |
CTD |
PMID:15867097 |
|
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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G |
Il12b |
interleukin 12B |
increases expression |
ISO |
KRN 7000 results in increased expression of IL12B protein |
CTD |
PMID:15867097 |
|
NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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G |
Abl1 |
ABL proto-oncogene 1, non-receptor tyrosine kinase |
multiple interactions |
ISO |
[Bortezomib co-treated with N,N-dimethylsphingosine] results in decreased expression of ABL1 protein |
CTD |
PMID:21195056 |
|
NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
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G |
Asah2 |
N-acylsphingosine amidohydrolase 2 |
multiple interactions |
ISO |
N,N-dimethylsphingosine inhibits the reaction [ASAH2 protein results in increased expression of BCL2 protein] |
CTD |
PMID:15498114 |
|
NCBI chr 1:229,865,662...229,973,253
Ensembl chr 1:229,865,662...229,939,162
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
N,N-dimethylsphingosine inhibits the reaction [ASAH2 protein results in increased expression of BCL2 protein] |
CTD |
PMID:15498114 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
C5 |
complement C5 |
multiple interactions |
ISO |
N,N-dimethylsphingosine inhibits the reaction [C5 protein results in increased activity of RELA protein] |
CTD |
PMID:19284563 |
|
NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
[Bortezomib co-treated with N,N-dimethylsphingosine] results in increased cleavage of and results in increased activity of CASP3 protein |
CTD |
PMID:21195056 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Fn1 |
fibronectin 1 |
multiple interactions |
EXP |
N,N-dimethylsphingosine inhibits the reaction [Glucose results in increased expression of FN1 protein] |
CTD |
PMID:21998146 |
|
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
multiple interactions |
ISO |
[Bortezomib co-treated with N,N-dimethylsphingosine] results in decreased expression of MCL1 protein |
CTD |
PMID:21195056 |
|
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
[Bortezomib co-treated with N,N-dimethylsphingosine] results in increased cleavage of PARP1 protein |
CTD |
PMID:21195056 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
N,N-dimethylsphingosine inhibits the reaction [C5 protein results in increased activity of RELA protein] |
CTD |
PMID:19284563 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Sphk1 |
sphingosine kinase 1 |
decreases activity multiple interactions decreases expression |
ISO EXP |
N,N-dimethylsphingosine results in decreased activity of SPHK1 protein N,N-dimethylsphingosine inhibits the reaction [Glucose results in increased activity of SPHK1 protein] N,N-dimethylsphingosine results in decreased expression of SPHK1 protein |
CTD |
PMID:17065523 PMID:19284563 PMID:21195056 PMID:21998146 |
|
NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases transport |
ISO |
ABCB1 protein results in increased transport of N-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproyl sphingosine |
CTD |
PMID:21436125 |
|
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases expression |
ISO |
N-acetylsphingosine results in increased expression of ABCB1 |
CTD |
PMID:11573427 |
|
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions decreases phosphorylation |
ISO |
BCL2 protein inhibits the reaction [N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; N-acetylsphingosine inhibits the reaction [CAV1 protein results in increased phosphorylation of AKT1 protein]; N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of AKT1 protein N-acetylsphingosine results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:12640124 PMID:16215670 PMID:21821001 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Bad |
BCL2-associated agonist of cell death |
decreases phosphorylation multiple interactions |
ISO |
N-acetylsphingosine results in decreased phosphorylation of BAD protein N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in decreased phosphorylation of BAD protein] |
CTD |
PMID:24420784 |
|
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
ISO |
N-acetylsphingosine results in increased expression of BAX mRNA N-acetylsphingosine promotes the reaction [Acetaminophen results in increased expression of BAX protein] |
CTD |
PMID:24420784 PMID:33959992 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression |
ISO |
BCL2 protein inhibits the reaction [N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased degradation of PLCG1 protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 mRNA]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 protein]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 protein] N-acetylsphingosine results in decreased expression of BCL2 mRNA; N-acetylsphingosine results in decreased expression of BCL2 protein |
CTD |
PMID:9295281 PMID:16215670 PMID:24420784 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions increases degradation |
ISO |
LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of BCL2L1 protein] |
CTD |
PMID:21821001 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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G |
Birc2 |
baculoviral IAP repeat-containing 2 |
decreases expression |
ISO |
[C2-ceramide cotreated with paclitaxel] decreases expression of BIRC2 mRNA in non-small cell lung cancer cells |
RGD |
PMID:20624405 |
RGD:152999014 |
NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
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G |
Birc3 |
baculoviral IAP repeat-containing 3 |
decreases expression |
ISO |
[C2-ceramide cotreated with paclitaxel] decreases expression of BIRC3 mRNA in non-small cell lung cancer cells |
RGD |
PMID:20624405 |
RGD:152999014 |
NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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G |
Casp3 |
caspase 3 |
multiple interactions increases activity |
ISO |
BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 protein]; N-acetylsphingosine promotes the reaction [Acetaminophen results in increased expression of CASP3 protein]; N-acetylsphingosine results in increased cleavage of and results in increased activity of CASP3 protein N-acetylsphingosine results in increased activity of CASP3 protein |
CTD |
PMID:10919278 PMID:16215670 PMID:21259059 PMID:28052715 PMID:33959992 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cav1 |
caveolin 1 |
multiple interactions |
ISO |
N-acetylsphingosine inhibits the reaction [CAV1 protein results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:12640124 |
|
NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
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G |
Cebpb |
CCAAT/enhancer binding protein beta |
multiple interactions decreases localization |
EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [N-acetylsphingosine results in decreased localization of CEBPB protein]; N-acetylsphingosine inhibits the reaction [oltipraz results in increased localization of CEBPB protein] |
CTD |
PMID:15319326 |
|
NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
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G |
Cftr |
CF transmembrane conductance regulator |
increases activity |
ISO |
N-acetylsphingosine results in increased activity of CFTR protein |
CTD |
PMID:15474513 |
|
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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G |
Cldn4 |
claudin 4 |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of CLDN4 mRNA; N-acetylsphingosine results in decreased expression of CLDN4 protein |
CTD |
PMID:28052715 |
|
NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436
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G |
Clk1 |
CDC-like kinase 1 |
increases expression |
ISO |
N-acetylsphingosine results in increased expression of CLK1 mRNA |
CTD |
PMID:18270325 |
|
NCBI chr 9:59,947,774...59,959,002
Ensembl chr 9:59,947,764...59,957,000
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G |
Ctsd |
cathepsin D |
increases secretion |
EXP |
N-acetylsphingosine results in increased secretion of CTSD protein |
CTD |
PMID:15040013 |
|
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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G |
Dapk1 |
death associated protein kinase 1 |
increases activity |
ISO EXP |
N-acetylsphingosine results in increased activity of DAPK1 protein |
CTD |
PMID:17087515 |
|
NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991
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G |
Dffb |
DNA fragmentation factor subunit beta |
increases activity |
EXP |
N-acetylsphingosine results in increased activity of DFFB protein |
CTD |
PMID:15040013 |
|
NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628
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G |
Dnm1l |
dynamin 1-like |
increases expression |
EXP |
N-acetylsphingosine results in increased expression of DNM1L protein |
CTD |
PMID:18006463 |
|
NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
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G |
Egf |
epidermal growth factor |
multiple interactions |
ISO |
N-acetylsphingosine inhibits the reaction [EGF protein results in increased abundance of Diglycerides] |
CTD |
PMID:11082532 |
|
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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G |
F3 |
coagulation factor III, tissue factor |
multiple interactions increases expression |
ISO |
N-acetylsphingosine promotes the reaction [IL1B protein results in increased expression of F3 protein] N-acetylsphingosine results in increased expression of F3 protein |
CTD |
PMID:27556861 |
|
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
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G |
Fis1 |
fission, mitochondrial 1 |
increases expression |
EXP |
N-acetylsphingosine results in increased expression of FIS1 protein |
CTD |
PMID:18006463 |
|
NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377
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G |
Got1 |
glutamic-oxaloacetic transaminase 1 |
multiple interactions |
ISO |
N-acetylsphingosine promotes the reaction [Acetaminophen results in increased activity of GOT1 protein] |
CTD |
PMID:33959992 |
|
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
N-acetylsphingosine promotes the reaction [Acetaminophen results in increased activity of GPT protein] |
CTD |
PMID:33959992 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gpx3 |
glutathione peroxidase 3 |
multiple interactions |
ISO |
N-acetylsphingosine promotes the reaction [Acetaminophen results in decreased activity of GPX3 protein] |
CTD |
PMID:33959992 |
|
NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
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G |
Gsk3a |
glycogen synthase kinase 3 alpha |
decreases phosphorylation |
ISO |
N-acetylsphingosine results in decreased phosphorylation of GSK3A protein |
CTD |
PMID:21821001 |
|
NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
decreases phosphorylation decreases expression multiple interactions |
ISO |
N-acetylsphingosine results in decreased phosphorylation of GSK3B protein N-acetylsphingosine results in decreased expression of GSK3B protein modified form GSK3B mutant form inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein] |
CTD |
PMID:21821001 PMID:24420784 |
|
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Gsta1 |
glutathione S-transferase alpha 1 |
multiple interactions |
ISO |
N-acetylsphingosine promotes the reaction [Acetaminophen results in decreased expression of and results in increased secretion of GSTA1 protein]; N-acetylsphingosine promotes the reaction [Acetaminophen results in decreased expression of GSTA1 mRNA]; N-acetylsphingosine promotes the reaction [Acetaminophen results in decreased expression of GSTA1 protein] |
CTD |
PMID:31385618 PMID:33959992 |
|
NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
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G |
Gsta2 |
glutathione S-transferase alpha 2 |
multiple interactions decreases expression |
EXP |
N-acetylsphingosine inhibits the reaction [2-tert-butylhydroquinone results in increased expression of GSTA2 protein]; N-acetylsphingosine inhibits the reaction [oltipraz results in increased expression of GSTA2 protein] N-acetylsphingosine results in decreased expression of GSTA2 protein |
CTD |
PMID:15155840 PMID:15319326 |
|
NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
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G |
Gsta3 |
glutathione S-transferase alpha 3 |
decreases expression |
EXP |
N-acetylsphingosine results in decreased expression of GSTA3 protein |
CTD |
PMID:15155840 |
|
NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
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G |
Gsta5 |
glutathione S-transferase alpha 5 |
decreases expression |
EXP |
N-acetylsphingosine results in decreased expression of GSTA5 protein |
CTD |
PMID:15155840 |
|
NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
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G |
Hmox1 |
heme oxygenase 1 |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of HMOX1 mRNA |
CTD |
PMID:18270325 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hnf1a |
HNF1 homeobox A |
multiple interactions decreases ubiquitination |
EXP ISO |
N-acetylsphingosine results in decreased expression of and results in decreased activity of HNF1A protein N-acetylsphingosine promotes the reaction [Acetaminophen results in decreased expression of HNF1A mRNA]; N-acetylsphingosine promotes the reaction [Acetaminophen results in decreased expression of HNF1A protein] N-acetylsphingosine results in decreased ubiquitination of HNF1A protein |
CTD |
PMID:15155840 PMID:31385618 PMID:33959992 |
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NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104
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G |
Hrk |
harakiri, BCL2 interacting protein |
increases expression multiple interactions |
ISO |
N-acetylsphingosine results in increased expression of HRK mRNA N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [N-acetylsphingosine results in increased expression of HRK mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in increased expression of HRK mRNA] |
CTD |
PMID:24420784 |
|
NCBI chr12:38,387,484...38,409,652
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G |
Id2 |
inhibitor of DNA binding 2 |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of ID2 mRNA |
CTD |
PMID:18270325 |
|
NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
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G |
Il16 |
interleukin 16 |
increases expression |
ISO |
N-acetylsphingosine results in increased expression of IL16 mRNA |
CTD |
PMID:18270325 |
|
NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
N-acetylsphingosine promotes the reaction [IL1B protein results in increased expression of F3 protein] |
CTD |
PMID:27556861 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
N-acetylsphingosine promotes the reaction [Acetaminophen results in increased phosphorylation of JUN protein] |
CTD |
PMID:33959992 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Kdr |
kinase insert domain receptor |
multiple interactions |
ISO |
N-acetylsphingosine results in decreased phosphorylation of and results in decreased activity of KDR protein sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of KDR mRNA] |
CTD |
PMID:15313899 PMID:15741222 |
|
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
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G |
Klf6 |
KLF transcription factor 6 |
increases expression |
ISO |
N-acetylsphingosine results in increased expression of KLF6 mRNA |
CTD |
PMID:18270325 |
|
NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570
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G |
Lgals3 |
galectin 3 |
multiple interactions increases expression decreases response to substance |
ISO |
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein]; GSK3B mutant form inhibits the reaction [N-acetylsphingosine results in increased expression of LGALS3 protein]; LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of BCL2L1 protein]; LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of MCL1 protein] LGALS3 results in decreased susceptibility to N-acetylsphingosine |
CTD |
PMID:21821001 |
|
NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
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G |
Map3k5 |
mitogen-activated protein kinase kinase kinase 5 |
multiple interactions |
ISO |
N-acetylsphingosine affects the phosphorylation of and results in increased activity of MAP3K5 protein; TXNIP affects the reaction [N-acetylsphingosine affects the phosphorylation of and results in increased activity of MAP3K5 protein] |
CTD |
PMID:18270325 |
|
NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases activity |
EXP |
N-acetylsphingosine results in increased activity of MAPK1 protein |
CTD |
PMID:10700234 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases activity |
EXP |
N-acetylsphingosine results in increased activity of MAPK3 protein |
CTD |
PMID:10700234 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
N-acetylsphingosine promotes the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:33959992 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions |
ISO |
N-acetylsphingosine results in increased phosphorylation of and results in increased activity of MAPK9 protein; TXNIP affects the reaction [N-acetylsphingosine results in increased phosphorylation of and results in increased activity of MAPK9 protein] |
CTD |
PMID:18270325 |
|
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
multiple interactions increases degradation |
ISO |
LGALS3 inhibits the reaction [N-acetylsphingosine results in increased degradation of MCL1 protein] |
CTD |
PMID:21821001 |
|
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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G |
Mdm2 |
MDM2 proto-oncogene |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of MDM2 mRNA; N-acetylsphingosine results in decreased expression of MDM2 protein |
CTD |
PMID:18206046 |
|
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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G |
Mfn2 |
mitofusin 2 |
decreases response to substance |
EXP |
MFN2 protein results in decreased susceptibility to N-acetylsphingosine |
CTD |
PMID:18006463 |
|
NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
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G |
Mir15b |
microRNA 15b |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of MIR15B mRNA |
CTD |
PMID:20145152 |
|
NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297
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G |
Mir20a |
microRNA 20a |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of MIR20A mRNA |
CTD |
PMID:20145152 |
|
NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168
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G |
Mir25 |
microRNA 25 |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of MIR25 mRNA |
CTD |
PMID:20145152 |
|
NCBI chr12:17,042,932...17,043,015
Ensembl chr12:17,042,932...17,043,015
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G |
Mir93 |
microRNA 93 |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of MIR93 mRNA |
CTD |
PMID:20145152 |
|
NCBI chr12:17,043,135...17,043,221
Ensembl chr12:17,043,135...17,043,221
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G |
Mirlet7b |
microRNA let-7b |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of MIRLET7B mRNA |
CTD |
PMID:20145152 |
|
NCBI chr 7:116,804,186...116,804,270
Ensembl chr 7:116,804,186...116,804,270
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G |
Mirlet7d |
microRNA let-7d |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of MIRLET7D mRNA |
CTD |
PMID:20145152 |
|
NCBI chr17:16,115,893...16,115,990
Ensembl chr17:16,115,893...16,115,990
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G |
Mirlet7i |
microRNA let-7i |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of MIRLET7I mRNA |
CTD |
PMID:20145152 |
|
NCBI chr 7:58,642,485...58,642,569
Ensembl chr 7:58,642,480...58,642,571
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions decreases localization |
EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [N-acetylsphingosine results in decreased localization of NFE2L2 protein]; N-acetylsphingosine inhibits the reaction [2-tert-butylhydroquinone results in increased localization of NFE2L2 protein] |
CTD |
PMID:15319326 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Ngf |
nerve growth factor |
multiple interactions |
EXP |
N-acetylsphingosine affects the reaction [Glutathione affects the activity of NGF protein] |
CTD |
PMID:12381813 |
|
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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G |
Nrp1 |
neuropilin 1 |
multiple interactions |
ISO |
sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP1 mRNA] |
CTD |
PMID:15741222 |
|
NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633
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G |
Nrp2 |
neuropilin 2 |
multiple interactions |
ISO |
sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP2 mRNA] |
CTD |
PMID:15741222 |
|
NCBI chr 9:64,122,815...64,238,007
Ensembl chr 9:64,123,132...64,237,958
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G |
Ocln |
occludin |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of OCLN mRNA; N-acetylsphingosine results in decreased expression of OCLN protein |
CTD |
PMID:28052715 |
|
NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
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G |
Odc1 |
ornithine decarboxylase 1 |
decreases activity |
ISO |
N-acetylsphingosine results in decreased activity of ODC1 protein |
CTD |
PMID:17521618 |
|
NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases activity |
ISO |
N-acetylsphingosine results in increased activity of PARP1 protein |
CTD |
PMID:24420784 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pink1 |
PTEN induced kinase 1 |
decreases response to substance |
ISO |
PINK1 protein results in decreased susceptibility to N-acetylsphingosine |
CTD |
PMID:24792327 |
|
NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
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G |
Plat |
plasminogen activator, tissue type |
multiple interactions |
ISO |
[N-acetylsphingosine results in increased abundance of Ceramides] which results in increased secretion of PLAT protein |
CTD |
PMID:11107162 |
|
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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G |
Plcg1 |
phospholipase C, gamma 1 |
multiple interactions increases degradation |
ISO |
BCL2 protein inhibits the reaction [N-acetylsphingosine results in increased degradation of PLCG1 protein] |
CTD |
PMID:16215670 |
|
NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
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G |
Raf1 |
Raf-1 proto-oncogene, serine/threonine kinase |
increases activity |
EXP |
N-acetylsphingosine results in increased activity of RAF1 protein |
CTD |
PMID:10700234 |
|
NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
affects activity |
ISO |
N-acetylsphingosine affects the activity of RELA protein |
CTD |
PMID:12853972 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Rhob |
ras homolog family member B |
increases expression |
ISO |
N-acetylsphingosine results in increased expression of RHOB mRNA |
CTD |
PMID:18270325 |
|
NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
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G |
Serpine1 |
serpin family E member 1 |
multiple interactions |
ISO |
[N-acetylsphingosine results in increased abundance of Ceramides] which results in decreased secretion of SERPINE1 protein |
CTD |
PMID:11107162 |
|
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
ISO |
N-acetylsphingosine promotes the reaction [Acetaminophen results in decreased activity of SOD1 protein] |
CTD |
PMID:33959992 |
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Sod2 |
superoxide dismutase 2 |
increases expression multiple interactions |
ISO EXP |
N-acetylsphingosine results in increased expression of SOD2 mRNA; N-acetylsphingosine results in increased expression of SOD2 protein Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of SOD2 protein] |
CTD |
PMID:9535218 PMID:10428046 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Sts |
steroid sulfatase |
multiple interactions |
ISO |
N-acetylsphingosine inhibits the reaction [Tretinoin results in increased activity of STS protein] |
CTD |
PMID:16178010 |
|
NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402
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G |
Tfe3 |
transcription factor binding to IGHM enhancer 3 |
multiple interactions |
ISO |
N-acetylsphingosine results in decreased phosphorylation of and affects the localization of TFE3 protein |
CTD |
PMID:29945972 |
|
NCBI chr X:14,729,547...14,742,830
Ensembl chr X:14,729,550...14,742,571
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G |
Tgif1 |
TGFB-induced factor homeobox 1 |
increases expression |
ISO |
N-acetylsphingosine results in increased expression of TGIF1 mRNA |
CTD |
PMID:18270325 |
|
NCBI chr 9:110,748,094...110,757,714
Ensembl chr 9:110,720,921...110,757,802
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G |
Tjp1 |
tight junction protein 1 |
decreases expression |
ISO |
N-acetylsphingosine results in decreased expression of TJP1 mRNA; N-acetylsphingosine results in decreased expression of TJP1 protein |
CTD |
PMID:28052715 |
|
NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
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G |
Tp53 |
tumor protein p53 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of TP53 mRNA]; Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of TP53 protein] N-acetylsphingosine results in increased expression of TP53 mRNA; N-acetylsphingosine results in increased expression of TP53 protein |
CTD |
PMID:9535218 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Txn1 |
thioredoxin 1 |
decreases activity multiple interactions |
ISO |
N-acetylsphingosine results in decreased activity of TXN protein TXNIP affects the reaction [N-acetylsphingosine results in decreased activity of TXN protein] |
CTD |
PMID:18270325 |
|
NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
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G |
Txnip |
thioredoxin interacting protein |
increases expression multiple interactions |
ISO |
N-acetylsphingosine results in increased expression of TXNIP protein N-acetylsphingosine results in increased expression of TXNIP mRNA; N-acetylsphingosine results in increased expression of TXNIP protein TXNIP affects the reaction [N-acetylsphingosine affects the phosphorylation of and results in increased activity of MAP3K5 protein]; TXNIP affects the reaction [N-acetylsphingosine results in decreased activity of TXN protein]; TXNIP affects the reaction [N-acetylsphingosine results in increased phosphorylation of and results in increased activity of MAPK9 protein] |
CTD |
PMID:18270325 |
|
NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
N-acetylsphingosine results in decreased expression of and results in decreased secretion of VEGFA protein |
CTD |
PMID:15313899 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Atf4 |
activating transcription factor 4 |
increases expression |
ISO |
dihydroceramide analog results in increased expression of ATF4 protein |
CTD |
PMID:32397857 |
|
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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G |
Casp3 |
caspase 3 |
increases cleavage |
ISO |
dihydroceramide metabolite results in increased cleavage of CASP3 protein |
CTD |
PMID:17586710 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp6 |
caspase 6 |
increases cleavage |
ISO |
dihydroceramide metabolite results in increased cleavage of CASP6 protein |
CTD |
PMID:17586710 |
|
NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
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G |
Casp9 |
caspase 9 |
increases cleavage |
ISO |
dihydroceramide metabolite results in increased cleavage of CASP9 protein |
CTD |
PMID:17586710 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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|
G |
Degs1 |
delta(4)-desaturase, sphingolipid 1 |
multiple interactions |
ISO |
[N-((1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl)octanamide results in decreased activity of DEGS1 protein] which results in decreased reduction of dihydroceramide |
CTD |
PMID:27635674 |
|
NCBI chr13:93,946,154...93,953,677
Ensembl chr13:93,946,157...93,953,664
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions |
ISO |
dihydroceramide analog results in increased expression of and results in increased lipidation of MAP1LC3B protein |
CTD |
PMID:32397857 |
|
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 Ensembl chr16:49,665,791...49,677,690
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G |
Trib3 |
tribbles pseudokinase 3 |
increases expression |
ISO |
dihydroceramide analog results in increased expression of TRIB3 protein |
CTD |
PMID:32397857 |
|
NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
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G |
Asah2 |
N-acylsphingosine amidohydrolase 2 |
multiple interactions |
ISO |
ASAH2 protein inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine] |
CTD |
PMID:15946935 |
|
NCBI chr 1:229,865,662...229,973,253
Ensembl chr 1:229,865,662...229,939,162
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G |
Atf4 |
activating transcription factor 4 |
increases expression multiple interactions |
ISO |
N-palmitoylsphingosine results in increased expression of ATF4 mRNA ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ATF4 mRNA] |
CTD |
PMID:28223344 |
|
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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G |
Atf6 |
activating transcription factor 6 |
increases expression multiple interactions |
ISO |
N-palmitoylsphingosine results in increased expression of ATF6 mRNA [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ATF6 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ATF6 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ATF6 mRNA] |
CTD |
PMID:28223344 |
|
NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
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G |
Cs |
citrate synthase |
decreases expression multiple interactions |
ISO |
N-palmitoylsphingosine results in decreased expression of CS mRNA [N-palmitoylsphingosine co-treated with Dietary Fats] results in decreased activity of CS protein; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in decreased activity of CS protein]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in decreased expression of CS mRNA] |
CTD |
PMID:28223344 |
|
NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions increases expression |
ISO |
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of DDIT3 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of DDIT3 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of DDIT3 mRNA] |
CTD |
PMID:28223344 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions increases expression |
ISO |
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of HSPA5 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of HSPA5 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of HSPA5 mRNA] |
CTD |
PMID:28223344 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Il1b |
interleukin 1 beta |
multiple interactions increases abundance |
ISO |
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [IL1B protein results in increased abundance of N-palmitoylsphingosine] |
CTD |
PMID:27556861 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Itpr1 |
inositol 1,4,5-trisphosphate receptor, type 1 |
multiple interactions increases expression |
ISO |
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR1 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR1 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ITPR1 mRNA] |
CTD |
PMID:28223344 |
|
NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
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G |
Itpr2 |
inositol 1,4,5-trisphosphate receptor, type 2 |
increases expression multiple interactions |
ISO |
N-palmitoylsphingosine results in increased expression of ITPR2 mRNA [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR2 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR2 mRNA]; ursodoxicoltaurine inhibits the reaction [N-palmitoylsphingosine results in increased expression of ITPR2 mRNA] |
CTD |
PMID:28223344 |
|
NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164
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G |
Lipc |
lipase C, hepatic type |
multiple interactions |
ISO |
[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of N-palmitoylsphingosine |
CTD |
PMID:24777581 |
|
NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464
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G |
Lipg |
lipase G, endothelial type |
multiple interactions |
ISO |
[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of N-palmitoylsphingosine |
CTD |
PMID:24777581 |
|
NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260
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G |
Mfn2 |
mitofusin 2 |
increases expression multiple interactions |
ISO |
N-palmitoylsphingosine results in increased expression of MFN2 mRNA [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of MFN2 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of MFN2 mRNA] |
CTD |
PMID:28223344 |
|
NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
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|
G |
Pacs2 |
phosphofurin acidic cluster sorting protein 2 |
increases expression multiple interactions |
ISO |
N-palmitoylsphingosine results in increased expression of PACS2 mRNA [N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of PACS2 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of PACS2 mRNA] |
CTD |
PMID:28223344 |
|
NCBI chr 6:132,096,992...132,156,702
Ensembl chr 6:132,096,901...132,154,583
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G |
Pc |
pyruvate carboxylase |
multiple interactions |
ISO |
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased activity of PC protein; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased activity of PC protein] |
CTD |
PMID:28223344 |
|
NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380
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|
G |
Tnf |
tumor necrosis factor |
increases abundance multiple interactions |
ISO |
TNF protein results in increased abundance of N-palmitoylsphingosine ASAH2 protein inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine] Imipramine inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine] |
CTD |
PMID:15946935 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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|
G |
Vdac1 |
voltage-dependent anion channel 1 |
multiple interactions |
ISO |
[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of VDAC1 mRNA; ursodoxicoltaurine inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of VDAC1 mRNA] |
CTD |
PMID:28223344 |
|
NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
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|
|
G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
affects localization multiple interactions |
ISO |
phytosphingosine affects the localization of AIFM1 protein 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [phytosphingosine affects the localization of AIFM1 protein] |
CTD |
PMID:15486061 |
|
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression affects localization |
ISO |
3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]; [arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein; Acetylcysteine inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]; SB 203580 inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased localization of BAX protein] phytosphingosine results in increased expression of BAX protein phytosphingosine affects the localization of BAX protein |
CTD |
PMID:15486061 PMID:17237268 PMID:36334778 PMID:37956922 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
increases expression |
ISO |
phytosphingosine results in increased expression of BCL2 protein |
CTD |
PMID:36334778 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Casp3 |
caspase 3 |
multiple interactions increases expression |
ISO |
3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of CASP3 protein]; [Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of CASP3 protein; phytosphingosine results in increased expression of and results in increased cleavage of CASP3 protein; SB 203580 inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of CASP3 protein] phytosphingosine results in increased expression of CASP3 protein |
CTD |
PMID:17237268 PMID:36334778 PMID:37956922 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp9 |
caspase 9 |
multiple interactions increases expression |
ISO |
3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP9 protein]; [arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP9 protein; SB 203580 inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased activity of CASP9 protein] phytosphingosine results in increased expression of CASP9 protein |
CTD |
PMID:17237268 PMID:37956922 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Ccnb1 |
cyclin B1 |
decreases expression |
ISO |
phytosphingosine results in decreased expression of CCNB1 protein |
CTD |
PMID:37956922 |
|
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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G |
Cdk1 |
cyclin-dependent kinase 1 |
decreases expression |
ISO |
phytosphingosine results in decreased expression of CDK1 protein |
CTD |
PMID:37956922 |
|
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Cycs |
cytochrome c, somatic |
increases expression |
ISO |
phytosphingosine results in increased expression of CYCS protein |
CTD |
PMID:36334778 |
|
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
[arsenic trioxide co-treated with phytosphingosine] results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:17237268 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions |
ISO |
3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein]; [arsenic trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein; Acetylcysteine inhibits the reaction [[arsenic trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein] |
CTD |
PMID:17237268 |
|
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
[arsenic trioxide co-treated with phytosphingosine] results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:17237268 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases cleavage increases activity |
ISO |
3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein]; [Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein; [Arsenic Trioxide co-treated with phytosphingosine] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein] phytosphingosine results in increased cleavage of PARP1 protein phytosphingosine results in increased activity of PARP1 protein |
CTD |
PMID:15486061 PMID:17237268 PMID:37956922 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pink1 |
PTEN induced kinase 1 |
decreases expression |
ISO |
phytosphingosine results in decreased expression of PINK1 protein |
CTD |
PMID:36334778 |
|
NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
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G |
Abca1 |
ATP binding cassette subfamily A member 1 |
decreases expression multiple interactions |
ISO |
Rosuvastatin Calcium results in decreased expression of ABCA1 mRNA Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of ABCA1 mRNA] |
CTD |
PMID:18192897 |
|
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
multiple interactions |
ISO EXP |
Rosuvastatin Calcium inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid] [Cyclosporine results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium; [Glyburide results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium; [troglitazone results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium |
CTD |
PMID:15901796 PMID:19853032 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions increases expression affects secretion |
ISO EXP |
ABCC2 protein binds to and results in increased uptake of Rosuvastatin Calcium analog; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein] Rosuvastatin Calcium results in increased expression of ABCC2 protein [Benzbromarone results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; [Probenecid results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; [Sulfasalazine results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; ABCC2 protein binds to and results in increased uptake of Rosuvastatin Calcium analog; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Rosuvastatin Calcium promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein] ABCC2 protein affects the secretion of Rosuvastatin Calcium |
CTD |
PMID:19853032 PMID:23562342 PMID:24909372 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
increases expression |
EXP |
Rosuvastatin Calcium results in increased expression of ABCC3 protein |
CTD |
PMID:24909372 |
|
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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G |
Abcg1 |
ATP binding cassette subfamily G member 1 |
decreases expression |
ISO |
Rosuvastatin Calcium results in decreased expression of ABCG1 mRNA |
CTD |
PMID:18192897 |
|
NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
multiple interactions increases activity |
EXP ISO |
[Novobiocin results in decreased activity of ABCG2 protein] which results in decreased secretion of Rosuvastatin Calcium Rosuvastatin Calcium results in increased activity of ABCG2 protein |
CTD |
PMID:19853032 PMID:30083819 |
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NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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G |
Ache |
acetylcholinesterase |
multiple interactions |
EXP |
[Piracetam co-treated with Rosuvastatin Calcium] inhibits the reaction [[Sodium Chloride, Dietary co-treated with Cholesterol, Dietary co-treated with Coconut Oil] results in increased activity of ACHE protein]; Rosuvastatin Calcium inhibits the reaction [[Sodium Chloride, Dietary co-treated with Cholesterol, Dietary co-treated with Coconut Oil] results in increased activity of ACHE protein] |
CTD |
PMID:28441890 |
|
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Akt1 |
AKT serine/threonine kinase 1 |
affects phosphorylation |
EXP |
Rosuvastatin Calcium affects the phosphorylation of AKT1 protein |
CTD |
PMID:27815113 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Apoa1 |
apolipoprotein A1 |
multiple interactions increases expression |
ISO |
Niacin promotes the reaction [Rosuvastatin Calcium results in increased expression of APOA1 protein] |
CTD |
PMID:12767421 PMID:15539964 |
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NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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G |
Apob |
apolipoprotein B |
decreases expression |
ISO |
Rosuvastatin Calcium results in decreased expression of APOB protein |
CTD |
PMID:15539964 PMID:18702965 |
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NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP |
Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of BAX mRNA] |
CTD |
PMID:32007421 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
Rosuvastatin Calcium results in decreased expression of BCL2 protein |
CTD |
PMID:20852871 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
C3 |
complement C3 |
decreases expression |
ISO |
Rosuvastatin Calcium results in decreased expression of C3 mRNA |
CTD |
PMID:32771489 |
|
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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G |
Casp3 |
caspase 3 |
increases activity increases expression |
ISO |
Rosuvastatin Calcium results in increased activity of CASP3 protein Rosuvastatin Calcium results in increased expression of CASP3 protein |
CTD |
PMID:21478229 PMID:32771489 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cat |
catalase |
increases activity multiple interactions |
EXP |
Rosuvastatin Calcium results in increased activity of CAT protein [Rosuvastatin Calcium co-treated with Isoproterenol] inhibits the reaction [Interleukin-6 results in increased expression of CAT protein]; Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in decreased activity of CAT protein] |
CTD |
PMID:20146376 PMID:32007421 PMID:35130744 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
decreases expression |
EXP |
Rosuvastatin Calcium results in decreased expression of CCL2 mRNA |
CTD |
PMID:15681303 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Creb5 |
cAMP responsive element binding protein 5 |
decreases expression |
ISO |
Rosuvastatin Calcium results in decreased expression of CREB5 mRNA |
CTD |
PMID:18192897 |
|
NCBI chr 4:82,393,091...82,794,320
Ensembl chr 4:82,393,730...82,790,325
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G |
Crp |
C-reactive protein |
multiple interactions |
ISO |
Rosuvastatin Calcium inhibits the reaction [CRP protein results in decreased expression of NOS3] |
CTD |
PMID:21562509 |
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NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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G |
Cyba |
cytochrome b-245 alpha chain |
multiple interactions decreases expression |
EXP |
[[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species |
CTD |
PMID:21562509 |
|
NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
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G |
Cybb |
cytochrome b-245 beta chain |
multiple interactions decreases expression |
ISO EXP |
Rosuvastatin Calcium inhibits the reaction [Nitroglycerin results in increased expression of CYBB mRNA] [[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species |
CTD |
PMID:16633368 PMID:21562509 |
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NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
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G |
Esr1 |
estrogen receptor 1 |
decreases expression |
ISO |
Rosuvastatin Calcium results in decreased expression of ESR1 protein |
CTD |
PMID:32771489 |
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression multiple interactions |
ISO |
Rosuvastatin Calcium results in increased expression of GCLC mRNA [Tetradecanoylphorbol Acetate co-treated with Rosuvastatin Calcium] results in increased expression of GCLC mRNA |
CTD |
PMID:18154958 |
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gpr183 |
G protein-coupled receptor 183 |
multiple interactions increases expression |
ISO |
Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in increased expression of GPR183 mRNA] |
CTD |
PMID:18192897 |
|
NCBI chr15:99,037,764...99,050,550
Ensembl chr15:99,036,367...99,050,559
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G |
Gzmk |
granzyme K |
multiple interactions increases expression |
ISO |
Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in increased expression of GZMK mRNA] |
CTD |
PMID:18192897 |
|
NCBI chr 2:44,840,811...44,848,829
Ensembl chr 2:44,840,811...44,848,894
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G |
Hnf4a |
hepatocyte nuclear factor 4, alpha |
increases secretion |
ISO |
HNF4A protein results in increased secretion of Rosuvastatin Calcium |
CTD |
PMID:27160211 |
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NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
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G |
Il18rap |
interleukin 18 receptor accessory protein |
decreases expression multiple interactions |
ISO |
Rosuvastatin Calcium results in decreased expression of IL18RAP mRNA Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of IL18RAP mRNA] |
CTD |
PMID:18192897 |
|
NCBI chr 9:42,768,112...42,800,964
Ensembl chr 9:42,768,220...42,800,959
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G |
Il1b |
interleukin 1 beta |
decreases expression |
EXP |
Rosuvastatin Calcium results in decreased expression of IL1B mRNA |
CTD |
PMID:15681303 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
Rosuvastatin Calcium results in decreased activity of KCNH2 protein |
CTD |
PMID:28551711 |
|
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Kcnj15 |
potassium inwardly-rectifying channel, subfamily J, member 15 |
decreases expression |
ISO |
Rosuvastatin Calcium results in decreased expression of KCNJ15 mRNA |
CTD |
PMID:18192897 |
|
NCBI chr11:34,577,397...34,621,725
Ensembl chr11:34,577,363...34,621,952
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G |
Kdr |
kinase insert domain receptor |
multiple interactions |
ISO |
Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein] |
CTD |
PMID:27097221 |
|
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
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G |
Mb |
myoglobin |
affects expression |
EXP |
Rosuvastatin Calcium affects the expression of MB protein |
CTD |
PMID:27815113 |
|
NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383
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G |
Mstn |
myostatin |
increases expression |
ISO |
Rosuvastatin Calcium results in increased expression of MSTN protein |
CTD |
PMID:33034787 |
|
NCBI chr 9:48,452,533...48,458,933
Ensembl chr 9:48,452,533...48,458,933
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
EXP |
Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in decreased expression of NFE2L2 mRNA] |
CTD |
PMID:32007421 PMID:35130744 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nos2 |
nitric oxide synthase 2 |
increases expression multiple interactions |
EXP |
Rosuvastatin Calcium results in increased expression of NOS2 mRNA Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of NOS2 mRNA] |
CTD |
PMID:21443142 PMID:32007421 PMID:35130744 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions increases expression affects response to substance |
ISO EXP |
Rosuvastatin Calcium inhibits the reaction [CRP protein results in decreased expression of NOS3]; Rosuvastatin Calcium results in increased phosphorylation of and results in increased activity of NOS3 protein Rosuvastatin Calcium results in increased expression of NOS3 mRNA NOS3 protein affects the susceptibility to Rosuvastatin Calcium |
CTD |
PMID:12354446 PMID:15681303 PMID:18162361 PMID:21562509 |
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NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Orm1 |
orosomucoid 1 |
multiple interactions decreases expression |
ISO |
Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of ORM1 mRNA] |
CTD |
PMID:18192897 |
|
NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154
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G |
Pecam1 |
platelet and endothelial cell adhesion molecule 1 |
multiple interactions |
ISO |
Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PECAM1 protein] |
CTD |
PMID:27097221 |
|
NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
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G |
Selp |
selectin P |
decreases expression |
EXP |
Rosuvastatin Calcium results in decreased expression of SELP mRNA |
CTD |
PMID:15681303 |
|
NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
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G |
Serpine2 |
serpin family E member 2 |
multiple interactions |
ISO |
Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SERPINE2 protein]; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein] |
CTD |
PMID:27097221 |
|
NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826
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G |
Slco1a4 |
solute carrier organic anion transporter family, member 1a4 |
multiple interactions increases uptake decreases expression affects transport |
EXP ISO |
Fusidic Acid inhibits the reaction [SLCO1A4 protein results in increased uptake of Rosuvastatin Calcium] diosmetin inhibits the reaction [SLCO1A2 protein results in increased uptake of Rosuvastatin Calcium] Rosuvastatin Calcium results in decreased expression of SLCO1A4 protein SLCO1A4 protein affects the transport of Rosuvastatin Calcium |
CTD |
PMID:19833843 PMID:24909372 PMID:26888941 PMID:28867436 |
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NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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G |
Slco1b2 |
solute carrier organic anion transporter family member 1B2 |
multiple interactions increases uptake |
EXP ISO |
Fusidic Acid inhibits the reaction [SLCO1B2 protein results in increased uptake of Rosuvastatin Calcium] Fusidic Acid inhibits the reaction [SLCO1B3 protein results in increased uptake of Rosuvastatin Calcium] |
CTD |
PMID:26888941 PMID:31299240 |
|
NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
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G |
Slco2b1 |
solute carrier organic anion transporter family, member 2b1 |
increases uptake multiple interactions |
ISO |
SLCO2B1 protein results in increased uptake of Rosuvastatin Calcium Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of Rosuvastatin Calcium] |
CTD |
PMID:24285294 |
|
NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions increases expression |
EXP |
[[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species |
CTD |
PMID:21562509 |
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Tff1 |
trefoil factor 1 |
decreases expression |
ISO |
Rosuvastatin Calcium results in decreased expression of TFF1 mRNA |
CTD |
PMID:32771489 |
|
NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions decreases expression |
ISO EXP |
Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TGFB1 protein]; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein] Rosuvastatin Calcium results in decreased expression of TGFB1 mRNA |
CTD |
PMID:15681303 PMID:27097221 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tnf |
tumor necrosis factor |
decreases expression multiple interactions |
EXP |
Rosuvastatin Calcium results in decreased expression of TNF mRNA Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of TNF protein] |
CTD |
PMID:15681303 PMID:32007421 PMID:35130744 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnni3 |
troponin I3, cardiac type |
multiple interactions |
EXP |
Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of TNNI3 protein] |
CTD |
PMID:32007421 PMID:35130744 |
|
NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
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G |
Vnn3 |
vanin 3 |
decreases expression |
ISO |
Rosuvastatin Calcium results in decreased expression of VNN3P mRNA |
CTD |
PMID:18192897 |
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NCBI chr 1:21,571,364...21,583,626
Ensembl chr 1:21,571,364...21,583,626
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G |
Wt1 |
WT1 transcription factor |
increases expression |
EXP |
Rosuvastatin Calcium results in increased expression of WT1 mRNA |
CTD |
PMID:21443142 |
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NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases expression |
ISO |
dihydrosphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; dihydrosphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 protein]; dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 protein] dihydrosphingosine 1-phosphate results in increased expression of PTGS2 mRNA; dihydrosphingosine 1-phosphate results in increased expression of PTGS2 protein |
CTD |
PMID:18612546 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Spns2 |
SPNS lysolipid transporter 2, sphingosine-1-phosphate |
decreases abundance |
ISO |
SPNS2 protein results in decreased abundance of dihydrosphingosine 1-phosphate |
CTD |
PMID:29772789 |
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NCBI chr10:57,067,348...57,105,969
Ensembl chr10:57,066,897...57,105,957
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G |
Crh |
corticotropin releasing hormone |
multiple interactions |
EXP |
Sphingosine inhibits the reaction [CRH protein inhibits the reaction [CGB3 protein results in increased chemical synthesis of Cyclic AMP]] |
CTD |
PMID:2153673 |
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NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
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G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
increases expression |
ISO |
Sphingosine results in increased expression of CYP17A1 mRNA |
CTD |
PMID:15666826 |
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NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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G |
Lhb |
luteinizing hormone subunit beta |
multiple interactions |
EXP |
Sphingosine inhibits the reaction [CRH protein inhibits the reaction [CGB3 protein results in increased chemical synthesis of Cyclic AMP]]; Sphingosine inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [CGB3 protein results in increased chemical synthesis of Cyclic AMP]] |
CTD |
PMID:2153673 |
|
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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G |
Tat |
tyrosine aminotransferase |
multiple interactions |
EXP |
Sphingosine inhibits the reaction [Calcimycin promotes the reaction [Dexamethasone results in increased activity of TAT protein]]; Sphingosine inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Dexamethasone results in increased activity of TAT protein]]; Sphingosine inhibits the reaction [Ursodeoxycholic Acid promotes the reaction [Dexamethasone results in increased activity of TAT protein]] |
CTD |
PMID:9398635 |
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NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031
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G |
Tert |
telomerase reverse transcriptase |
affects activity |
ISO |
Sphingosine affects the activity of TERT protein |
CTD |
PMID:9434777 |
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NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561
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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions increases expression |
EXP |
sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of ACTA2 mRNA]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of ACTA2 protein] sphingosine 1-phosphate results in increased expression of ACTA2 mRNA; sphingosine 1-phosphate results in increased expression of ACTA2 protein |
CTD |
PMID:37169277 |
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NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions increases phosphorylation |
ISO |
sphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of AKT1 protein sphingosine 1-phosphate results in increased phosphorylation of AKT1 protein |
CTD |
PMID:15946935 PMID:16365044 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Atg5 |
autophagy related 5 |
increases expression multiple interactions |
EXP |
sphingosine 1-phosphate results in increased expression of ATG5 mRNA; sphingosine 1-phosphate results in increased expression of ATG5 protein 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of ATG5 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of ATG5 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of ATG5 mRNA]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of ATG5 protein] |
CTD |
PMID:37169277 |
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NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
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G |
Bax |
BCL2 associated X, apoptosis regulator |
decreases expression multiple interactions |
ISO |
sphingosine 1-phosphate results in decreased expression of BAX mRNA sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA] |
CTD |
PMID:24399507 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BCL2 mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 protein] |
CTD |
PMID:24399507 PMID:24420784 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Becn1 |
beclin 1 |
increases expression multiple interactions |
EXP |
sphingosine 1-phosphate results in increased expression of BECN1 mRNA; sphingosine 1-phosphate results in increased expression of BECN1 protein sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of BECN1 mRNA]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of BECN1 protein] |
CTD |
PMID:37169277 |
|
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Casp1 |
caspase 1 |
multiple interactions |
EXP |
sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of and results in increased cleavage of CASP1 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of CASP1 mRNA] |
CTD |
PMID:37169277 |
|
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Ccn2 |
cellular communication network factor 2 |
increases expression |
ISO |
sphingosine 1-phosphate results in increased expression of CCN2 mRNA |
CTD |
PMID:25690654 |
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NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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G |
Col1a1 |
collagen type I alpha 1 chain |
increases expression multiple interactions |
EXP |
sphingosine 1-phosphate results in increased expression of COL1A1 mRNA; sphingosine 1-phosphate results in increased expression of COL1A1 protein 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of COL1A1 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of COL1A1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [sphingosine 1-phosphate results in increased expression of COL1A1 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of COL1A1 mRNA] |
CTD |
PMID:37169277 |
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NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Creb1 |
cAMP responsive element binding protein 1 |
increases phosphorylation multiple interactions |
ISO |
sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein] |
CTD |
PMID:18612546 |
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NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Cxcr1 |
C-X-C motif chemokine receptor 1 |
decreases expression |
ISO |
sphingosine 1-phosphate results in decreased expression of CXCR1 mRNA |
CTD |
PMID:16224106 |
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NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084
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G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
increases expression |
ISO |
sphingosine 1-phosphate results in increased expression of CYP17A1 mRNA |
CTD |
PMID:15666826 |
|
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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G |
Egfr |
epidermal growth factor receptor |
increases phosphorylation multiple interactions |
ISO |
sphingosine 1-phosphate results in increased phosphorylation of EGFR protein JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of EGFR protein] |
CTD |
PMID:26518876 |
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NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Fn1 |
fibronectin 1 |
multiple interactions increases expression |
EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of and results in increased lipidation of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein; [sphingosine 1-phosphate results in increased activity of S1PR2 protein] which results in increased expression of FN1; Curcumin inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; SB 203580 inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of FN1 protein] |
CTD |
PMID:21998146 PMID:22406263 PMID:37169277 |
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NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Gnaq |
G protein subunit alpha q |
multiple interactions increases expression |
ISO |
Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of GNAQ protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of GNAQ protein] |
CTD |
PMID:25980589 |
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NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672
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G |
Gsk3a |
glycogen synthase kinase 3 alpha |
multiple interactions |
ISO |
sphingosine 1-phosphate inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3A protein]; Wortmannin inhibits the reaction [sphingosine 1-phosphate inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3A protein]] |
CTD |
PMID:25769802 |
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NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions |
ISO |
sphingosine 1-phosphate affects the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3B protein]; Wortmannin affects the reaction [sphingosine 1-phosphate affects the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3B protein]] |
CTD |
PMID:25769802 |
|
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Hgf |
hepatocyte growth factor |
increases expression |
ISO |
sphingosine 1-phosphate results in increased expression of HGF mRNA |
CTD |
PMID:19349368 |
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NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
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G |
Hrk |
harakiri, BCL2 interacting protein |
multiple interactions |
ISO |
sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HRK mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in increased expression of HRK mRNA] |
CTD |
PMID:24399507 PMID:24420784 |
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NCBI chr12:38,387,484...38,409,652
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G |
Hsf1 |
heat shock transcription factor 1 |
increases activity |
ISO |
sphingosine 1-phosphate results in increased activity of HSF1 protein |
CTD |
PMID:34170685 |
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NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
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G |
Igf1 |
insulin-like growth factor 1 |
increases expression |
ISO |
sphingosine 1-phosphate results in increased expression of IGF1 mRNA |
CTD |
PMID:19349368 |
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NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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G |
Il18 |
interleukin 18 |
multiple interactions |
EXP |
3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL18 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL18 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL18 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of IL18 protein] |
CTD |
PMID:37169277 |
|
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il1b |
interleukin 1 beta |
increases expression multiple interactions increases secretion |
ISO |
sphingosine 1-phosphate results in increased expression of IL1B mRNA Janus Kinase Inhibitors inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]; Janus Kinase Inhibitors inhibits the reaction [sphingosine 1-phosphate results in increased secretion of IL1B protein]; S1PR1 protein affects the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]; STAT3 protein affects the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]; STAT3 protein affects the reaction [sphingosine 1-phosphate results in increased secretion of IL1B protein] |
CTD |
PMID:32401414 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions increases expression |
ISO |
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL6 mRNA] |
CTD |
PMID:26518876 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Jak2 |
Janus kinase 2 |
increases phosphorylation |
ISO |
sphingosine 1-phosphate results in increased phosphorylation of JAK2 protein |
CTD |
PMID:32401414 |
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NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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G |
Kdr |
kinase insert domain receptor |
multiple interactions |
ISO |
sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of KDR mRNA]; sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of KDR mRNA] |
CTD |
PMID:15741222 |
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NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
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G |
Lama3 |
laminin subunit alpha 3 |
increases expression |
ISO |
sphingosine 1-phosphate results in increased expression of LAMA3 mRNA |
CTD |
PMID:15541073 |
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NCBI chr18:3,523,168...3,751,722
Ensembl chr18:3,523,133...3,751,353
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G |
Lamb3 |
laminin subunit beta 3 |
increases expression |
ISO |
sphingosine 1-phosphate results in increased expression of LAMB3 mRNA |
CTD |
PMID:15541073 |
|
NCBI chr13:104,833,810...104,875,405
Ensembl chr13:104,833,873...104,875,405
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G |
Lamc2 |
laminin subunit gamma 2 |
increases expression |
ISO |
sphingosine 1-phosphate results in increased expression of LAMC2 mRNA |
CTD |
PMID:15541073 |
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NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions increases expression |
EXP |
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of and results in increased lipidation of MAP1LC3B protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of MAP1LC3B mRNA]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased phosphorylation of and results in increased lipidation of MAP1LC3B protein]; sphingosine 1-phosphate results in increased phosphorylation of and results in increased lipidation of MAP1LC3B protein sphingosine 1-phosphate results in increased expression of MAP1LC3B mRNA |
CTD |
PMID:37169277 |
|
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 Ensembl chr16:49,665,791...49,677,690
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases phosphorylation |
ISO EXP |
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]; Plant Extracts inhibits the reaction [sphingosine 1-phosphate results in increased activity of and results in increased phosphorylation of MAPK1 protein]; sphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of MAPK1 protein; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein] 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK1 protein modified form]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK1 protein modified form |
CTD |
PMID:16365044 PMID:18612546 PMID:22251058 PMID:22406263 PMID:26518876 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions increases phosphorylation |
ISO EXP |
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]; Plant Extracts inhibits the reaction [sphingosine 1-phosphate results in increased activity of and results in increased phosphorylation of MAPK3 protein]; sphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of MAPK3 protein; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein] 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK3 protein modified form]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK3 protein modified form |
CTD |
PMID:16365044 PMID:18612546 PMID:22251058 PMID:22406263 PMID:26518876 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions increases expression |
ISO |
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP2 mRNA]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP2 protein] sphingosine 1-phosphate results in increased expression of MMP2 mRNA; sphingosine 1-phosphate results in increased expression of MMP2 protein |
CTD |
PMID:26518876 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions increases expression |
ISO |
Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein] sphingosine 1-phosphate results in increased expression of MMP9 mRNA; sphingosine 1-phosphate results in increased expression of MMP9 protein |
CTD |
PMID:25980589 PMID:26518876 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions |
EXP |
3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of NLRP3 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of NLRP3 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [sphingosine 1-phosphate results in increased expression of NLRP3 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of NLRP3 mRNA]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of NLRP3 protein] |
CTD |
PMID:37169277 |
|
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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G |
Nrp1 |
neuropilin 1 |
multiple interactions |
ISO |
sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP1 mRNA]; sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP1 mRNA] |
CTD |
PMID:15741222 |
|
NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633
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G |
Nrp2 |
neuropilin 2 |
multiple interactions |
ISO |
sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP2 mRNA]; sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP2 mRNA] |
CTD |
PMID:15741222 |
|
NCBI chr 9:64,122,815...64,238,007
Ensembl chr 9:64,123,132...64,237,958
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G |
Pecam1 |
platelet and endothelial cell adhesion molecule 1 |
increases expression |
ISO |
sphingosine 1-phosphate results in increased expression of PECAM1 protein |
CTD |
PMID:19349368 |
|
NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
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G |
Plcb4 |
phospholipase C, beta 4 |
increases expression multiple interactions |
ISO |
sphingosine 1-phosphate results in increased expression of PLCB4 protein Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of PLCB4 protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of PLCB4 protein] |
CTD |
PMID:25980589 |
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NCBI chr 3:122,952,965...123,322,522
Ensembl chr 3:122,953,196...123,322,392
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
EXP |
[Bezafibrate results in increased activity of PPARA protein] which results in decreased abundance of sphingosine 1-phosphate |
CTD |
PMID:18024222 |
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NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases expression |
ISO |
dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; JTE 013 inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; JTE 013 promotes the reaction [Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; MK 2206 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; S1PR2 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; S1PR3 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 protein]; sphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; Suramin inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; Suramin promotes the reaction [JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]] sphingosine 1-phosphate results in increased expression of PTGS2 mRNA; sphingosine 1-phosphate results in increased expression of PTGS2 protein |
CTD |
PMID:18612546 PMID:26518876 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions affects localization |
ISO |
JTE 013 inhibits the reaction [sphingosine 1-phosphate affects the localization of RELA protein modified form] |
CTD |
PMID:26518876 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
S1pr1 |
sphingosine-1-phosphate receptor 1 |
increases response to substance affects binding multiple interactions increases expression |
EXP ISO |
S1PR1 protein results in increased susceptibility to sphingosine 1-phosphate S1PR1 protein binds to sphingosine 1-phosphate S1PR1 protein affects the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA] sphingosine 1-phosphate results in increased expression of S1PR1 mRNA sphingosine 1-phosphate binds to and results in increased activity of S1PR1 protein |
CTD |
PMID:20844107 PMID:24399507 PMID:32401414 PMID:35412894 |
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NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681
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G |
S1pr2 |
sphingosine-1-phosphate receptor 2 |
multiple interactions increases expression increases uptake increases activity |
ISO EXP |
S1PR2 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA] sphingosine 1-phosphate results in increased expression of S1PR2 protein sphingosine 1-phosphate results in increased uptake of S1PR2 protein sphingosine 1-phosphate results in increased activity of S1PR2 protein [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] results in decreased susceptibility to [sphingosine 1-phosphate co-treated with Glucose]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] which results in decreased susceptibility to sphingosine 1-phosphate; [sphingosine 1-phosphate results in increased activity of S1PR2 protein] which results in increased expression of FN1; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR2 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of S1PR2 protein] |
CTD |
PMID:18612546 PMID:22406263 PMID:26518876 PMID:37169277 |
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NCBI chr 8:19,503,276...19,514,169
Ensembl chr 8:19,502,627...19,523,574
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G |
S1pr3 |
sphingosine-1-phosphate receptor 3 |
multiple interactions increases expression |
ISO |
Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR3 protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR3 protein]; S1PR3 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA] |
CTD |
PMID:18612546 PMID:25980589 |
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NCBI chr17:13,781,050...13,794,408
Ensembl chr17:13,781,050...13,794,505
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G |
S1pr5 |
sphingosine-1-phosphate receptor 5 |
multiple interactions |
ISO |
Endocannabinoids inhibits the reaction [sphingosine 1-phosphate binds to and results in increased activity of S1PR5 protein]; sphingosine 1-phosphate binds to and results in increased activity of S1PR5 protein |
CTD |
PMID:30102254 |
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NCBI chr 8:19,786,676...19,791,862
Ensembl chr 8:19,786,663...19,791,795
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G |
Smad3 |
SMAD family member 3 |
increases phosphorylation |
EXP |
sphingosine 1-phosphate results in increased phosphorylation of SMAD3 protein |
CTD |
PMID:37169277 |
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NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
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G |
Smpd2 |
sphingomyelin phosphodiesterase 2 |
multiple interactions |
ISO |
sphingosine 1-phosphate inhibits the reaction [Thalidomide results in increased activity of SMPD2 protein] |
CTD |
PMID:15741222 |
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NCBI chr20:44,986,229...44,989,343
Ensembl chr20:44,986,231...44,989,441
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G |
Sphk1 |
sphingosine kinase 1 |
increases chemical synthesis multiple interactions |
ISO |
SPHK1 protein results in increased chemical synthesis of sphingosine 1-phosphate [resveratrol affects the localization of and results in decreased activity of SPHK1 protein] which results in decreased abundance of sphingosine 1-phosphate; sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SPHK1 mRNA]; sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SPHK1 protein] |
CTD |
PMID:22251058 PMID:24399507 PMID:26045781 |
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NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
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G |
Spns2 |
SPNS lysolipid transporter 2, sphingosine-1-phosphate |
increases secretion multiple interactions |
ISO |
SPNS2 protein results in increased secretion of sphingosine 1-phosphate TGFB2 protein promotes the reaction [SPNS2 protein results in increased secretion of sphingosine 1-phosphate] |
CTD |
PMID:29772789 |
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NCBI chr10:57,067,348...57,105,969
Ensembl chr10:57,066,897...57,105,957
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G |
Sqstm1 |
sequestosome 1 |
decreases expression |
EXP |
sphingosine 1-phosphate results in decreased expression of SQSTM1 protein |
CTD |
PMID:37169277 |
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NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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G |
Stat3 |
signal transducer and activator of transcription 3 |
increases phosphorylation multiple interactions |
ISO |
sphingosine 1-phosphate results in increased phosphorylation of STAT3 protein Janus Kinase Inhibitors inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of STAT3 protein]; STAT3 protein affects the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]; STAT3 protein affects the reaction [sphingosine 1-phosphate results in increased secretion of IL1B protein] |
CTD |
PMID:32401414 |
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Tgfb2 |
transforming growth factor, beta 2 |
multiple interactions |
ISO |
TGFB2 protein promotes the reaction [SPNS2 protein results in increased secretion of sphingosine 1-phosphate] |
CTD |
PMID:29772789 |
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NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
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G |
Tnf |
tumor necrosis factor |
multiple interactions increases expression |
ISO |
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of TNF mRNA]; sphingosine 1-phosphate inhibits the reaction [TNF results in increased expression of VCAM1] |
CTD |
PMID:18981156 PMID:26518876 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO |
sphingosine 1-phosphate inhibits the reaction [TNF results in increased expression of VCAM1] |
CTD |
PMID:18981156 |
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NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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