CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: ametryn
Accession: CHEBI:22472
browse the term
Definition: A methylthio-1,3,5-triazine that is 2-(methylsulfanyl)-1,3,5-triazine substituted by an ethylamino and an isopropylamino group at positions 4 and 6 respectively.
Synonyms: exact_synonym: N(2)-ethyl-N(4)-isopropyl-6-(methylthio)-1,3,5-triazine-2,4-diamine
related_synonym: 2-ethylamino-4-isopropylamino-6-methylmercapto-s-triazine; 2-methylthio-4-ethylamino-6-isopropylamino-s-triazine; Ametrex; Evik; Formula=C9H17N5S; Gesapax; InChI=1S/C9H17N5S/c1-5-10-7-12-8(11-6(2)3)14-9(13-7)15-4/h6H,5H2,1-4H3,(H2,10,11,12,13,14); InChIKey=RQVYBGPQFYCBGX-UHFFFAOYSA-N; N(2)-ethyl-6-(methylsulfanyl)-N(4)-(propan-2-yl)-1,3,5-triazine-2,4-diamine; N-ethyl-6-(methylsulfanyl)-N'-(propan-2-yl)-1,3,5-triazine-2,4-diamine; N-ethyl-N'-(1-methylethyl)-6-(methylthio)-1,3,5-triazine-2,4-diamine; N-ethyl-N'-(1-methylethyl)-6-(methylthio)-2,4-diaminetriazine; N-ethyl-N'-isopropyl-6-(methylthio)-1,3,5-triazine-2,4-diamine; SMILES=CCNc1nc(NC(C)C)nc(SC)n1; ametryne
xref: Beilstein:613099; CAS:834-12-8; KEGG:C18700
xref_mesh: MESH:C100057
xref: MetaCyc:CPD-9343; PDBeChem:RYN; PMID:21626650; PMID:23566464; PMID:24413480; PMID:24579518; PMID:24757962; PPDB:27; Pesticides:ametryn; Reaxys:613099; UM-BBD_compID:c0260
G
Cdh1
cadherin 1
decreases expression
EXP
ametryne results in decreased expression of CDH1 mRNA
CTD
PMID:26310382
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
G
Cdh2
cadherin 2
increases expression
EXP
ametryne results in increased expression of CDH2 mRNA
CTD
PMID:26310382
NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions increases metabolic processing
ISO
POR protein promotes the reaction [CYP1A2 protein results in increased metabolism of ametryne]
CTD
PMID:8971136
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Gja1
gap junction protein, alpha 1
decreases expression
EXP
ametryne results in decreased expression of GJA1 mRNA
CTD
PMID:26310382
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
G
Gstm1
glutathione S-transferase mu 1
increases expression
EXP
ametryne results in increased expression of GSTM1 mRNA
CTD
PMID:26310382
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
G
Por
cytochrome p450 oxidoreductase
multiple interactions
ISO
POR protein promotes the reaction [CYP1A2 protein results in increased metabolism of ametryne]
CTD
PMID:8971136
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
G
Sod2
superoxide dismutase 2
increases expression
EXP
ametryne results in increased expression of SOD2 mRNA
CTD
PMID:26310382
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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