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G |
Gria3 |
glutamate ionotropic receptor AMPA type subunit 3 |
affects response to substance |
ISO |
GRIA3 protein affects the susceptibility to 5-fluorowillardiine |
CTD |
PMID:15264227 |
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NCBI chr X:120,238,515...120,504,106
Ensembl chr X:120,238,534...120,504,096
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G |
Cacna1h |
calcium voltage-gated channel subunit alpha1 H |
multiple interactions |
ISO |
3-cyanoalanine inhibits the reaction [[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of CACNA1H protein] |
CTD |
PMID:29129814 |
|
NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376
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G |
Egr1 |
early growth response 1 |
multiple interactions |
ISO |
3-cyanoalanine inhibits the reaction [[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of EGR1 protein] |
CTD |
PMID:29129814 |
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NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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G |
Usp5 |
ubiquitin specific peptidase 5 |
multiple interactions |
ISO |
3-cyanoalanine inhibits the reaction [[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of USP5 protein] |
CTD |
PMID:29129814 |
|
NCBI chr 4:157,619,663...157,634,681
Ensembl chr 4:157,619,643...157,634,711
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G |
Ctsd |
cathepsin D |
multiple interactions |
EXP |
alliin affects the reaction [Isoproterenol affects the activity of CTSD protein] |
CTD |
PMID:17623887 |
|
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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G |
Fasn |
fatty acid synthase |
multiple interactions |
ISO |
alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of FASN mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of FASN protein] |
CTD |
PMID:29305303 |
|
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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G |
Fgf2 |
fibroblast growth factor 2 |
decreases secretion multiple interactions |
ISO |
alliin results in decreased secretion of FGF2 protein alliin promotes the reaction [FGF2 protein results in increased expression of TP53 protein] |
CTD |
PMID:16351512 |
|
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
multiple interactions |
EXP ISO |
alliin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein] alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR protein] |
CTD |
PMID:16640830 PMID:29305303 |
|
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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G |
Lcat |
lecithin cholesterol acyltransferase |
multiple interactions |
EXP |
alliin inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein] |
CTD |
PMID:16640830 |
|
NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions |
ISO |
alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF1 mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF1 protein] |
CTD |
PMID:29305303 |
|
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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G |
Srebf2 |
sterol regulatory element binding transcription factor 2 |
multiple interactions |
ISO |
alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF2 mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF2 protein] |
CTD |
PMID:29305303 |
|
NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
alliin promotes the reaction [FGF2 protein results in increased expression of TP53 protein] |
CTD |
PMID:16351512 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Vegfa |
vascular endothelial growth factor A |
decreases secretion |
ISO |
alliin results in decreased secretion of VEGFA protein |
CTD |
PMID:16351512 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions |
ISO |
2-(methylamino)isobutyric acid inhibits the reaction [arsenite results in increased expression of DDIT3 mRNA] |
CTD |
PMID:22215663 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions |
ISO |
2-(methylamino)isobutyric acid inhibits the reaction [arsenite results in increased expression of HSPA5 mRNA] |
CTD |
PMID:22215663 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Igf1 |
insulin-like growth factor 1 |
increases uptake multiple interactions |
EXP |
IGF1 protein results in increased uptake of 2-(methylamino)isobutyric acid oxophenylarsine inhibits the reaction [IGF1 protein results in increased uptake of 2-(methylamino)isobutyric acid] |
CTD |
PMID:1928324 |
|
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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G |
Ins1 |
insulin 1 |
increases uptake increases transport multiple interactions |
EXP |
INS1 protein results in increased uptake of 2-(methylamino)isobutyric acid INS1 protein results in increased transport of 2-(methylamino)isobutyric acid Wortmannin inhibits the reaction [INS1 protein results in increased uptake of 2-(methylamino)isobutyric acid] |
CTD |
PMID:1847587 PMID:9877156 |
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NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
multiple interactions |
ISO |
2-(methylamino)isobutyric acid inhibits the reaction [arsenite results in increased phosphorylation of RPS6KB1 protein] |
CTD |
PMID:22215663 |
|
NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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G |
Slc38a2 |
solute carrier family 38, member 2 |
multiple interactions |
ISO |
SLC38A2 mutant form inhibits the reaction [arsenite results in increased transport of 2-(methylamino)isobutyric acid] |
CTD |
PMID:22215663 |
|
NCBI chr 7:127,851,267...127,863,482
Ensembl chr 7:127,851,267...127,863,436
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G |
Alad |
aminolevulinate dehydratase |
decreases activity |
EXP |
Selenocysteine analog results in decreased activity of ALAD protein |
CTD |
PMID:14630126 |
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NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
Selenocysteine inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of FOS protein]; Selenocysteine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of FOS protein] |
CTD |
PMID:14572605 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Gsta2 |
glutathione S-transferase alpha 2 |
increases expression |
EXP |
Selenocysteine results in increased expression of GSTA2 mRNA |
CTD |
PMID:12034368 |
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NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
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G |
Gsta3 |
glutathione S-transferase alpha 3 |
increases expression |
EXP |
Selenocysteine results in increased expression of GSTA3 mRNA |
CTD |
PMID:12034368 |
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NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
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G |
Gsta5 |
glutathione S-transferase alpha 5 |
increases expression |
EXP |
Selenocysteine results in increased expression of GSTA5 mRNA |
CTD |
PMID:12034368 |
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NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
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G |
Gstp1 |
glutathione S-transferase pi 1 |
increases expression |
EXP |
Selenocysteine results in increased expression of GSTP1 mRNA |
CTD |
PMID:12034368 |
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
Selenocysteine inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of RELA protein]; Selenocysteine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of RELA protein] |
CTD |
PMID:14572605 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Kyat1 |
kynurenine aminotransferase 1 |
increases amination |
ISO |
KYAT1 protein results in increased amination of lanthionine |
CTD |
PMID:22093698 |
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NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
LCL161 binds to and affects the activity of ABCB1 protein; LCL161 inhibits the reaction [ABCB1 protein results in increased export of Fluorescent Dyes]; LCL161 inhibits the reaction [ABCB1 protein results in increased export of mitotracker green FM] |
CTD |
PMID:32497533 |
|
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Birc2 |
baculoviral IAP repeat-containing 2 |
decreases expression decreases expression |
ISO |
LCL161 results in decreased expression of BIRC2 protein LCL161 decreases expression of BIRC2 protein in hepatocellular carcinoma cells |
CTD RGD |
PMID:32497533 PMID:24976294 |
RGD:153305953 |
NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
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G |
Birc3 |
baculoviral IAP repeat-containing 3 |
decreases expression |
ISO |
LCL161 decreases expression of BIRC3 protein in hepatocellular carcinoma cells |
RGD |
PMID:24976294 |
RGD:153305953 |
NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
decreases expression |
ISO |
LCL161 results in decreased expression of BIRC5 protein |
CTD |
PMID:32497533 |
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NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Xiap |
X-linked inhibitor of apoptosis |
decreases expression |
ISO |
LCL161 decreases expression of XIAP protein in hepatocellular carcinoma cells |
RGD |
PMID:24976294 |
RGD:153305953 |
NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
decreases expression |
ISO |
metalaxyl results in decreased expression of CYP2C19 protein |
CTD |
PMID:32194361 |
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NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
decreases expression |
ISO |
metalaxyl results in decreased expression of CYP7A1 protein |
CTD |
PMID:32194361 |
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NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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G |
Ncoa2 |
nuclear receptor coactivator 2 |
multiple interactions |
ISO |
N-benzoylalanine promotes the reaction [THRA protein binds to NCOA2 protein]; N-benzoylalanine promotes the reaction [THRB protein binds to NCOA2 protein] |
CTD |
PMID:31566444 |
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NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
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G |
Thra |
thyroid hormone receptor alpha |
multiple interactions |
ISO |
N-benzoylalanine promotes the reaction [THRA protein binds to NCOA2 protein] |
CTD |
PMID:31566444 |
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NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
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G |
Thrb |
thyroid hormone receptor beta |
multiple interactions affects binding |
ISO |
N-benzoylalanine promotes the reaction [THRB protein binds to NCOA2 protein] N-benzoylalanine binds to THRB protein |
CTD |
PMID:31566444 |
|
NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
multiple interactions |
ISO |
[selenomethylselenocysteine co-treated with irinotecan] results in decreased expression of ABCC1 |
CTD |
PMID:15897249 |
|
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
multiple interactions decreases expression |
EXP |
Isoflavones promotes the reaction [selenomethylselenocysteine results in decreased expression of ABCC4 mRNA] |
CTD |
PMID:19025659 |
|
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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G |
Apaf1 |
apoptotic peptidase activating factor 1 |
increases expression |
ISO |
selenomethylselenocysteine metabolite results in increased expression of APAF1 mRNA |
CTD |
PMID:25321483 |
|
NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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G |
Ar |
androgen receptor |
decreases expression |
ISO EXP |
selenomethylselenocysteine results in decreased expression of AR protein selenomethylselenocysteine results in decreased expression of AR mRNA |
CTD |
PMID:16637076 PMID:19025659 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Bak1 |
BCL2-antagonist/killer 1 |
increases expression |
ISO |
selenomethylselenocysteine metabolite results in increased expression of BAK1 mRNA |
CTD |
PMID:25321483 |
|
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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G |
Banp |
Btg3 associated nuclear protein |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of BANP mRNA |
CTD |
PMID:18514395 |
|
NCBI chr19:50,007,710...50,082,742
Ensembl chr19:50,007,881...50,082,738
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions |
ISO EXP |
selenomethylselenocysteine results in decreased expression of BCL2 mRNA [selenomethylselenocysteine results in decreased expression of BCL2 mRNA] which results in increased activity of TNFSF10 protein selenomethylselenocysteine results in decreased expression of BCL2 protein |
CTD |
PMID:11396176 PMID:19360359 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression |
ISO |
selenomethylselenocysteine metabolite results in decreased expression of BCL2L1 mRNA |
CTD |
PMID:25321483 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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G |
Bcl2l11 |
Bcl2-like 11 |
increases expression |
ISO |
selenomethylselenocysteine metabolite results in increased expression of BCL2L11 mRNA |
CTD |
PMID:25321483 |
|
NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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G |
Bmal1 |
basic helix-loop-helix ARNT like 1 |
decreases expression |
EXP |
selenomethylselenocysteine results in decreased expression of BMAL1 mRNA |
CTD |
PMID:19122877 |
|
NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231
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G |
Bmf |
Bcl2 modifying factor |
multiple interactions increases expression |
ISO |
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP3 protein modified form]; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP6 protein modified form]; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP9 protein modified form]; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of PARP1 protein modified form]; HDAC8 inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]; selenomethylselenocysteine metabolite inhibits the reaction [HDAC8 protein binds to BMF promoter]; selenomethylselenocysteine metabolite inhibits the reaction [STAT3 protein binds to BMF promoter]; selenomethylselenocysteine metabolite promotes the reaction [EP300 protein binds to BMF promoter]; selenomethylselenocysteine metabolite promotes the reaction [SP3 protein binds to BMF promoter]; STAT3 protein inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA] selenomethylselenocysteine metabolite results in increased expression of BMF protein selenomethylselenocysteine metabolite results in increased expression of BMF mRNA; selenomethylselenocysteine metabolite results in increased expression of BMF protein |
CTD |
PMID:25321483 |
|
NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145
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G |
Casp3 |
caspase 3 |
increases activity multiple interactions increases expression |
ISO |
selenomethylselenocysteine results in increased activity of CASP3 protein BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP3 protein modified form] |
CTD |
PMID:15318939 PMID:25321483 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp6 |
caspase 6 |
increases expression multiple interactions |
ISO |
selenomethylselenocysteine metabolite results in increased expression of CASP6 protein modified form BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP6 protein modified form] |
CTD |
PMID:25321483 |
|
NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
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G |
Casp8 |
caspase 8 |
increases expression |
ISO |
selenomethylselenocysteine metabolite results in increased expression of CASP8 protein modified form |
CTD |
PMID:25321483 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
multiple interactions increases expression |
ISO |
BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP9 protein modified form] |
CTD |
PMID:25321483 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Ccna2 |
cyclin A2 |
decreases expression |
EXP |
selenomethylselenocysteine results in decreased expression of CCNA2 protein |
CTD |
PMID:11396176 |
|
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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G |
Ccnd1 |
cyclin D1 |
decreases expression multiple interactions |
ISO EXP |
selenomethylselenocysteine results in decreased expression of CCND1 protein selenomethylselenocysteine results in decreased expression of CCND1 mRNA; selenomethylselenocysteine results in decreased expression of CCND1 protein [selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of CCND1 protein |
CTD |
PMID:11396176 PMID:18855134 PMID:19276161 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Cdk2 |
cyclin dependent kinase 2 |
multiple interactions |
ISO |
selenomethylselenocysteine results in decreased phosphorylation of and results in decreased activity of CDK2 protein |
CTD |
PMID:10656618 |
|
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression multiple interactions |
ISO |
selenomethylselenocysteine metabolite results in increased expression of CDKN1A protein [Aminooxyacetic Acid results in decreased metabolism of selenomethylselenocysteine] which results in decreased expression of CDKN1A protein |
CTD |
PMID:25321483 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
increases expression |
EXP |
selenomethylselenocysteine results in increased expression of CDKN1B protein |
CTD |
PMID:11396176 PMID:19276161 |
|
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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G |
Ces1d |
carboxylesterase 1D |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of CES1 |
CTD |
PMID:15897249 |
|
NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
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G |
Chmp1a |
charged multivesicular body protein 1A |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of CHMP1A mRNA |
CTD |
PMID:18514395 |
|
NCBI chr19:51,238,153...51,246,433
Ensembl chr19:51,238,160...51,246,436
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G |
Col1a1 |
collagen type I alpha 1 chain |
decreases expression |
ISO |
selenomethylselenocysteine results in decreased expression of COL1A1 mRNA; selenomethylselenocysteine results in decreased expression of COL1A1 protein |
CTD |
PMID:18514395 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Col1a2 |
collagen type I alpha 2 chain |
decreases expression |
ISO |
selenomethylselenocysteine results in decreased expression of COL1A2 mRNA; selenomethylselenocysteine results in decreased expression of COL1A2 protein |
CTD |
PMID:18514395 |
|
NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
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G |
Col4a5 |
collagen type IV alpha 5 chain |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of COL4A5 mRNA |
CTD |
PMID:18514395 |
|
NCBI chr X:105,118,762...105,322,699
Ensembl chr X:105,118,820...105,322,692
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G |
Col6a1 |
collagen type VI alpha 1 chain |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of COL6A1 mRNA |
CTD |
PMID:18514395 |
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NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597
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G |
Col7a1 |
collagen type VII alpha 1 chain |
decreases expression |
ISO |
selenomethylselenocysteine results in decreased expression of COL7A1 mRNA |
CTD |
PMID:18514395 |
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NCBI chr 8:109,604,877...109,637,249
Ensembl chr 8:109,604,861...109,637,252
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G |
Cry2 |
cryptochrome circadian regulator 2 |
increases expression |
EXP |
selenomethylselenocysteine results in increased expression of CRY2 mRNA |
CTD |
PMID:19122877 |
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NCBI chr 3:78,374,995...78,405,001
Ensembl chr 3:78,374,995...78,404,965
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G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
multiple interactions |
ISO |
[selenomethylselenocysteine co-treated with irinotecan] results in increased expression of CYP3A5 |
CTD |
PMID:15897249 |
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NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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G |
Dbp |
D-box binding PAR bZIP transcription factor |
increases expression |
EXP |
selenomethylselenocysteine results in increased expression of DBP mRNA |
CTD |
PMID:19122877 |
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NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of DDIT3 mRNA |
CTD |
PMID:10656618 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Dhcr24 |
24-dehydrocholesterol reductase |
decreases expression |
EXP |
selenomethylselenocysteine results in decreased expression of DHCR24 mRNA |
CTD |
PMID:19025659 |
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NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137
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G |
Drg1 |
developmentally regulated GTP binding protein 1 |
multiple interactions |
ISO |
[selenomethylselenocysteine co-treated with irinotecan] results in decreased expression of DRG1 |
CTD |
PMID:15897249 |
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NCBI chr14:78,103,876...78,119,976
Ensembl chr14:78,103,876...78,119,953
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G |
Ep300 |
E1A binding protein p300 |
multiple interactions |
ISO |
selenomethylselenocysteine metabolite promotes the reaction [EP300 protein binds to BMF promoter] |
CTD |
PMID:25321483 |
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NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088 Ensembl chr 7:113,106,247...113,136,088
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G |
Esr1 |
estrogen receptor 1 |
decreases expression multiple interactions |
ISO |
selenomethylselenocysteine results in decreased expression of ESR1 protein [selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of ESR1 protein |
CTD |
PMID:18855134 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Faslg |
Fas ligand |
multiple interactions |
ISO |
[selenomethylselenocysteine co-treated with irinotecan] results in increased expression of FASLG |
CTD |
PMID:15897249 |
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NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of GADD45A mRNA |
CTD |
PMID:10656618 |
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NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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G |
Gpx1 |
glutathione peroxidase 1 |
increases activity increases expression |
ISO |
selenomethylselenocysteine results in increased activity of GPX1 protein selenomethylselenocysteine results in increased expression of GPX1 mRNA; selenomethylselenocysteine results in increased expression of GPX1 protein |
CTD |
PMID:18514395 PMID:19033020 |
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NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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G |
Gpx4 |
glutathione peroxidase 4 |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of GPX4 mRNA |
CTD |
PMID:18514395 |
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NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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G |
Grik1 |
glutamate ionotropic receptor kainate type subunit 1 |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of GRIK1 mRNA |
CTD |
PMID:18514395 |
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NCBI chr11:27,169,739...27,571,131
Ensembl chr11:27,169,740...27,570,645
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G |
Grik3 |
glutamate ionotropic receptor kainate type subunit 3 |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of GRIK3 mRNA |
CTD |
PMID:18514395 |
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NCBI chr 5:137,767,865...137,989,617
Ensembl chr 5:137,767,865...137,984,307
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G |
Hdac8 |
histone deacetylase 8 |
multiple interactions |
ISO |
HDAC8 inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]; selenomethylselenocysteine metabolite inhibits the reaction [HDAC8 protein binds to BMF promoter] |
CTD |
PMID:25321483 |
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NCBI chr X:67,385,288...67,593,014
Ensembl chr X:67,385,289...67,592,923
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G |
Igf1r |
insulin-like growth factor 1 receptor |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of IGF1R mRNA |
CTD |
PMID:18514395 |
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NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases phosphorylation |
EXP |
selenomethylselenocysteine results in increased phosphorylation of JUN protein |
CTD |
PMID:19276161 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Klk1b3 |
kallikrein 1-related peptidase B3 |
decreases expression |
ISO |
selenomethylselenocysteine results in decreased expression of KLK3 protein |
CTD |
PMID:16637076 |
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NCBI chr 1:94,709,105...94,713,308
Ensembl chr 1:94,709,105...94,713,308
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G |
Mki67 |
marker of proliferation Ki-67 |
multiple interactions decreases expression |
ISO |
[selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of MKI67 protein selenomethylselenocysteine results in decreased expression of MKI67 protein |
CTD |
PMID:18855134 |
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NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Msrb1 |
methionine sulfoxide reductase B1 |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of MSRB1 mRNA |
CTD |
PMID:18514395 |
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NCBI chr10:13,764,883...13,770,609
Ensembl chr10:13,764,883...13,770,609
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased localization of NFKB1 protein] |
CTD |
PMID:21213327 |
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NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] |
CTD |
PMID:21213327 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
P4ha1 |
prolyl 4-hydroxylase subunit alpha 1 |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of P4HA1 mRNA |
CTD |
PMID:18514395 |
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NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases expression |
ISO |
[Aminooxyacetic Acid results in decreased metabolism of selenomethylselenocysteine] which results in decreased expression of PARP1 protein modified form; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of PARP1 protein modified form] |
CTD |
PMID:25321483 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Per2 |
period circadian regulator 2 |
increases expression |
EXP |
selenomethylselenocysteine results in increased expression of PER2 mRNA |
CTD |
PMID:19122877 |
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NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459
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G |
Per3 |
period circadian regulator 3 |
increases expression |
EXP |
selenomethylselenocysteine results in increased expression of PER3 mRNA |
CTD |
PMID:19122877 |
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NCBI chr 5:161,460,228...161,495,404
Ensembl chr 5:161,459,533...161,495,607
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G |
Pgr |
progesterone receptor |
decreases expression multiple interactions |
ISO |
selenomethylselenocysteine results in decreased expression of PGR protein [selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of PGR protein |
CTD |
PMID:18855134 |
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NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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G |
Ppp1r15a |
protein phosphatase 1, regulatory subunit 15A |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of PPP1R15A mRNA |
CTD |
PMID:10656618 |
|
NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
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G |
Prkce |
protein kinase C, epsilon |
decreases expression |
ISO |
selenomethylselenocysteine results in decreased expression of PRKCE protein |
CTD |
PMID:10656618 |
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NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
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G |
Prkcz |
protein kinase C, zeta |
decreases expression |
ISO |
selenomethylselenocysteine results in decreased expression of PRKCZ protein |
CTD |
PMID:10656618 |
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NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
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G |
Rab3b |
RAB3B, member RAS oncogene family |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of RAB3B mRNA |
CTD |
PMID:18514395 |
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NCBI chr 5:123,629,562...123,697,410
Ensembl chr 5:123,644,423...123,697,401
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G |
Rab4a |
RAB4A, member RAS oncogene family |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of RAB4A mRNA |
CTD |
PMID:18514395 |
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NCBI chr19:51,795,613...51,822,706
Ensembl chr19:51,795,613...51,822,703
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein] |
CTD |
PMID:21213327 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Scarb1 |
scavenger receptor class B, member 1 |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of SCARB1 mRNA |
CTD |
PMID:18514395 |
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NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
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G |
Selenof |
selenoprotein F |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of SELENOF mRNA |
CTD |
PMID:18514395 |
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NCBI chr 2:233,642,075...233,674,853
Ensembl chr 2:233,641,932...233,674,846
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G |
Selenop |
selenoprotein P |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of SELENOP mRNA |
CTD |
PMID:18514395 |
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NCBI chr 2:52,498,123...52,508,409
Ensembl chr 2:52,498,339...52,508,852
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G |
Selenow |
selenoprotein W |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of SELENOW mRNA |
CTD |
PMID:18514395 |
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NCBI chr 1:76,599,441...76,604,514
Ensembl chr 1:76,598,779...76,604,724 Ensembl chr 1:76,598,779...76,604,724
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G |
Slc3a1 |
solute carrier family 3 member 1 |
increases uptake |
ISO |
SLC3A1 protein results in increased uptake of selenomethylselenocysteine |
CTD |
PMID:18845132 |
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NCBI chr 6:9,608,169...9,641,881
Ensembl chr 6:9,608,178...9,641,907
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G |
Slc6a19 |
solute carrier family 6 member 19 |
increases uptake |
ISO |
SLC6A19 protein results in increased uptake of selenomethylselenocysteine |
CTD |
PMID:18845132 |
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NCBI chr 1:29,586,191...29,604,964
Ensembl chr 1:29,586,195...29,604,962
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G |
Slc6a20a |
solute carrier family 6 member 20a |
increases uptake |
ISO |
SLC6A20B protein results in increased uptake of selenomethylselenocysteine |
CTD |
PMID:18845132 |
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NCBI chr 8:123,282,325...123,322,609
Ensembl chr 8:123,281,472...123,322,573
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G |
Snap23 |
synaptosome associated protein 23 |
decreases expression |
ISO |
selenomethylselenocysteine results in decreased expression of SNAP23 mRNA |
CTD |
PMID:18514395 |
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NCBI chr 3:107,514,088...107,546,177
Ensembl chr 3:107,514,131...107,544,320
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G |
Sort1 |
sortilin 1 |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of SORT1 mRNA |
CTD |
PMID:18514395 |
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NCBI chr 2:195,924,033...196,002,354
Ensembl chr 2:195,924,099...196,002,354
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G |
Sp3 |
Sp3 transcription factor |
multiple interactions |
ISO |
selenomethylselenocysteine metabolite promotes the reaction [SP3 protein binds to BMF promoter] |
CTD |
PMID:25321483 |
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NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342
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G |
Spp1 |
secreted phosphoprotein 1 |
decreases expression |
ISO |
selenomethylselenocysteine results in decreased expression of SPP1 protein |
CTD |
PMID:15318939 |
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NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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G |
Srd5a1 |
steroid 5 alpha-reductase 1 |
multiple interactions |
EXP |
[selenomethylselenocysteine co-treated with Isoflavones] results in decreased activity of SRD5A1 protein |
CTD |
PMID:19025659 |
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NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO |
selenomethylselenocysteine metabolite inhibits the reaction [STAT3 protein binds to BMF promoter]; STAT3 protein inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA] |
CTD |
PMID:25321483 |
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Stx3 |
syntaxin 3 |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of STX3 mRNA |
CTD |
PMID:18514395 |
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NCBI chr 1:208,617,018...208,686,240
Ensembl chr 1:208,639,115...208,685,805
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G |
Tnfsf10 |
TNF superfamily member 10 |
multiple interactions |
ISO |
[selenomethylselenocysteine results in decreased expression of BCL2 mRNA] which results in increased activity of TNFSF10 protein |
CTD |
PMID:19360359 |
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NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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G |
Trnau1ap |
tRNA selenocysteine 1 associated protein 1 |
increases expression |
ISO |
selenomethylselenocysteine results in increased expression of TRNAU1AP mRNA |
CTD |
PMID:18514395 |
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NCBI chr 5:144,507,044...144,524,142
Ensembl chr 5:144,507,615...144,524,131
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G |
Xpa |
XPA, DNA damage recognition and repair factor |
multiple interactions |
ISO |
selenomethylselenocysteine inhibits the reaction [Zinc binds to XPA protein] |
CTD |
PMID:15265038 |
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NCBI chr 5:60,431,673...60,475,726
Ensembl chr 5:60,431,673...60,475,726
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G |
Klrc1 |
killer cell lectin like receptor C1 |
decreases expression |
ISO |
sofosbuvir co-treated with ledipasvir decreased expression of NCR1 protein in natural killer cells |
RGD |
PMID:31218578 |
RGD:40400920 |
NCBI chr 4:163,142,142...163,152,425
Ensembl chr 4:163,147,189...163,152,425
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G |
Ncr1 |
natural cytotoxicity triggering receptor 1 |
affects expression |
ISO |
sofosbuvir co-treated with ledipasvir affects expression of NCR1 protein in natural killer cells |
RGD |
PMID:31218578 |
RGD:40400920 |
NCBI chr 1:69,614,744...69,622,594
Ensembl chr 1:69,616,601...69,660,558
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