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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Dimerumic acid
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Accession:CHEBI:222323 term browser browse the term
Synonyms:exact_synonym: (E)-N,5-dihydroxy-N-[3-[5-[3-[hydroxy-[(E)-5-hydroxy-3-methylpent-2-enoyl]amino]propyl]-3,6-dioxopiperazin-2-yl]propyl]-3-methylpent-2-enamide
 related_synonym: Formula=C22H36N4O8;   InChI=1S/C22H36N4O8/c1-15(7-11-27)13-19(29)25(33)9-3-5-17-21(31)24-18(22(32)23-17)6-4-10-26(34)20(30)14-16(2)8-12-28/h13-14,17-18,27-28,33-34H,3-12H2,1-2H3,(H,23,32)(H,24,31)/b15-13+,16-14+;   InChIKey=MKDKGLNKTMDNHY-WXUKJITCSA-N;   SMILES=O=C1NC(C(=O)NC1CCCN(O)C(=O)/C=C(/CCO)\\C)CCCN(O)C(=O)/C=C(/CCO)\\C
 xref: Chemspider:4947731
 xref_mesh: MESH:C552122


show annotations for term's descendants           Sort by:
Dimerumic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions		 ISO dimerumic acid results in decreased expression of ACTA2 mRNA
NFE2L2 protein affects the reaction [dimerumic acid results in decreased expression of ACTA2 mRNA]		 CTD PMID:24036144 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions
decreases expression		 ISO NFE2L2 protein affects the reaction [dimerumic acid results in decreased expression of AGER mRNA] CTD PMID:24036144 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression
multiple interactions		 ISO dimerumic acid results in decreased expression of COL1A1 mRNA
NFE2L2 protein affects the reaction [dimerumic acid results in decreased expression of COL1A1 mRNA]		 CTD PMID:24036144 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
increases activity		 ISO dimerumic acid results in increased expression of GCLC mRNA
NFE2L2 protein affects the reaction [dimerumic acid results in increased expression of GCLC mRNA]
dimerumic acid results in increased activity of GCLC protein		 CTD PMID:24036144 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases activity		 ISO NFE2L2 protein affects the reaction [dimerumic acid results in decreased expression of ACTA2 mRNA]; NFE2L2 protein affects the reaction [dimerumic acid results in decreased expression of AGER mRNA]; NFE2L2 protein affects the reaction [dimerumic acid results in decreased expression of COL1A1 mRNA]; NFE2L2 protein affects the reaction [dimerumic acid results in decreased expression of PDGFRB mRNA]; NFE2L2 protein affects the reaction [dimerumic acid results in increased expression of GCLC mRNA]
dimerumic acid results in increased activity of NFE2L2 protein		 CTD PMID:24036144 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases expression
multiple interactions		 ISO dimerumic acid results in decreased expression of PDGFRB mRNA
NFE2L2 protein affects the reaction [dimerumic acid results in decreased expression of PDGFRB mRNA]		 CTD PMID:24036144 NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    chemical entity 19920
      atom 19892
        nonmetal atom 19849
          nitrogen atom 19025
            nitrogen molecular entity 19025
              organonitrogen compound 18846
                Dimerumic acid 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    main group molecular entity 19838
                      s-block molecular entity 19698
                        hydrogen molecular entity 19679
                          hydrides 19181
                            inorganic hydride 18192
                              pnictogen hydride 18157
                                nitrogen hydride 18070
                                  azane 17873
                                    ammonia 17898
                                      organic amino compound 17898
                                        amino acid 16074
                                          alpha-amino acid 13947
                                            Dimerumic acid 6
paths to the root