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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Dimerumic acid
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Accession:CHEBI:222323 term browser browse the term
Synonyms:related_synonym: (E)-N,5-dihydroxy-N-[3-[5-[3-[hydroxy-[(E)-5-hydroxy-3-methylpent-2-enoyl]amino]propyl]-3,6-dioxopiperazin-2-yl]propyl]-3-methylpent-2-enamide
 xref: Chemspider:4947731
 xref_mesh: MESH:C552122
 chemrof_smiles: C/C(=CC(=O)N(O)CCCC1NC(=O)C(CCCN(O)C(=O)/C=C(C)CCO)NC1=O)CCO
 chemrof_formula: C22H36N4O8
 chemrof_inchi: InChI=1S/C22H36N4O8/c1-15(7-11-27)13-19(29)25(33)9-3-5-17-21(31)24-18(22(32)23-17)6-4-10-26(34)20(30)14-16(2)8-12-28/h13-14,17-18,27-28,33-34H,3-12H2,1-2H3,(H,23,32)(H,24,31)/b15-13+,16-14+
 chemrof_inchikey: MKDKGLNKTMDNHY-WXUKJITCSA-N
 cyclic_relationship: has_functional_parent CHEBI:33704


show annotations for term's descendants           Sort by:
Dimerumic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions 		ISO dimerumic acid results in decreased expression of ACTA2 mRNA
NFE2L2 protein affects the reaction [dimerumic acid results in decreased expression of ACTA2 mRNA] 		CTD PMID:24036144 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions
decreases expression 		ISO NFE2L2 protein affects the reaction [dimerumic acid results in decreased expression of AGER mRNA] CTD PMID:24036144 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,151,965...4,155,685 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression
multiple interactions 		ISO dimerumic acid results in decreased expression of COL1A1 mRNA
NFE2L2 protein affects the reaction [dimerumic acid results in decreased expression of COL1A1 mRNA] 		CTD PMID:24036144 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
increases activity 		ISO dimerumic acid results in increased expression of GCLC mRNA
NFE2L2 protein affects the reaction [dimerumic acid results in increased expression of GCLC mRNA]
dimerumic acid results in increased activity of GCLC protein 		CTD PMID:24036144 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases activity 		ISO NFE2L2 protein affects the reaction [dimerumic acid results in decreased expression of ACTA2 mRNA]; NFE2L2 protein affects the reaction [dimerumic acid results in decreased expression of AGER mRNA]; NFE2L2 protein affects the reaction [dimerumic acid results in decreased expression of COL1A1 mRNA]; NFE2L2 protein affects the reaction [dimerumic acid results in decreased expression of PDGFRB mRNA]; NFE2L2 protein affects the reaction [dimerumic acid results in increased expression of GCLC mRNA]
dimerumic acid results in increased activity of NFE2L2 protein 		CTD PMID:24036144 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases expression
multiple interactions 		ISO dimerumic acid results in decreased expression of PDGFRB mRNA
NFE2L2 protein affects the reaction [dimerumic acid results in decreased expression of PDGFRB mRNA] 		CTD PMID:24036144 NCBI chr18:56,770,348...56,809,228
Ensembl chr18:56,770,348...56,809,233 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    chemical entity 20872
      atom 20872
        nonmetal atom 20781
          nitrogen atom 19576
            nitrogen molecular entity 19576
              organonitrogen compound 19311
                Dimerumic acid 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            heteroorganic entity 20201
                              organochalcogen compound 19822
                                organooxygen compound 19713
                                  Dimerumic acid 6
paths to the root