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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:6-O-methylguanine
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Accession:CHEBI:20689 term browser browse the term
Definition:A methylguanine in which the methyl group is positioned on the oxygen at position 6. Formed in DNA by alkylation of the oxygen atom of guanine, most often by N-nitroso compounds and sometimes due to methylation by other compounds such as endogenous S-adenosylmethionine, it base-pairs to thymine rather than cytidine, causing a G:C to A:T transition in DNA.
Synonyms:exact_synonym: 6-methoxy-7H-purin-2-amine
 related_synonym: 2-Amino-6-methoxypurine;   6-Methoxy-1H-purine-2-amine;   6-Methoxyguanine;   Formula=C6H7N5O;   InChI=1S/C6H7N5O/c1-12-5-3-4(9-2-8-3)10-6(7)11-5/h2H,1H3,(H3,7,8,9,10,11);   InChIKey=BXJHWYVXLGLDMZ-UHFFFAOYSA-N;   SMILES=COc1nc(N)nc2nc[nH]c12
 xref: CAS:20535-83-5
 xref_mesh: MESH:C008449
 xref: PMID:1474583;   PMID:15239064;   PMID:22185597;   PMID:2271591;   Reaxys:5334996;   Wikipedia:6-O-Methylguanine


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6-O-methylguanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of APAF1 mRNA CTD PMID:29666243 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of BBC3 mRNA CTD PMID:29666243 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of BID mRNA CTD PMID:29666243 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of BTG2 mRNA CTD PMID:29666243 NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628 		JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in increased expression of CCNA2 protein CTD PMID:29666243 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in increased expression of CCNB1 protein CTD PMID:29666243 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of CDKN1A mRNA; [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of CDKN1A protein CTD PMID:29666243 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Plk2 polo-like kinase 2 multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of PLK2 mRNA CTD PMID:29666243 NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of PMAIP1 mRNA CTD PMID:29666243 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in increased expression of RB1 protein modified form CTD PMID:29666243 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Sfn stratifin multiple interactions ISO [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of SFN mRNA CTD PMID:29666243 NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [O(6)-benzylguanine results in increased susceptibility to O-(6)-methylguanine] which results in increased expression of TP53 mRNA mutant form CTD PMID:29666243 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Wrn WRN RecQ like helicase decreases response to substance ISO WRN protein results in decreased susceptibility to O-(6)-methylguanine CTD PMID:29616805 NCBI chr16:58,763,517...58,898,604
Ensembl chr16:58,763,504...58,895,450 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19917
    role 19887
      biological role 19885
        aetiopathogenetic role 19259
          genotoxin 17691
            mutagen 17604
              6-O-methylguanine 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19917
    subatomic particle 19915
      composite particle 19915
        hadron 19915
          baryon 19915
            nucleon 19915
              atomic nucleus 19915
                atom 19915
                  main group element atom 19855
                    p-block element atom 19855
                      carbon group element atom 19774
                        carbon atom 19790
                          organic molecular entity 19790
                            organic molecule 19743
                              organic cyclic compound 19533
                                organic heterocyclic compound 18903
                                  organic heteropolycyclic compound 18317
                                    organic heterobicyclic compound 17257
                                      imidazopyrimidine 7758
                                        purines 7760
                                          aminopurine 6729
                                            2-aminopurines 6303
                                              guanine 6276
                                                methylguanine 16
                                                  6-O-methylguanine 13
paths to the root