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G |
Akr1c1 |
aldo-keto reductase family 1, member C1 |
affects reduction increases reduction |
ISO |
AKR1C1 protein affects the reduction of 5-alpha-Dihydroprogesterone AKR1C1 protein results in increased reduction of 5-alpha-Dihydroprogesterone |
CTD |
PMID:11995921 PMID:12604236 |
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NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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G |
Akr1c2 |
aldo-keto reductase family 1, member C2 |
affects reduction increases reduction |
ISO |
AKR1C2 protein affects the reduction of 5-alpha-Dihydroprogesterone AKR1C2 protein results in increased reduction of 5-alpha-Dihydroprogesterone |
CTD |
PMID:11995921 PMID:12604236 |
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NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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G |
Akr1c3 |
aldo-keto reductase family 1, member C3 |
increases chemical synthesis |
ISO |
AKR1C3 protein results in increased chemical synthesis of 5-alpha-Dihydroprogesterone |
CTD |
PMID:25463305 |
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NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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G |
Akr1d1 |
aldo-keto reductase family 1, member D1 |
increases chemical synthesis multiple interactions |
ISO |
AKR1D1 protein results in increased chemical synthesis of 5-alpha-Dihydroprogesterone AKR1D1 protein alternative form results in increased chemical synthesis of 5-alpha-Dihydroprogesterone [AKR1D1 protein alternative form results in increased reduction of Progesterone] which results in increased chemical synthesis of 5-alpha-Dihydroprogesterone |
CTD |
PMID:18624455 PMID:30928400 |
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NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions increases expression |
ISO |
3-hydroxypregn-4-en-20-one inhibits the reaction [5-alpha-Dihydroprogesterone results in increased expression of BCL2 mRNA] |
CTD |
PMID:19931389 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
increases hydroxylation |
ISO |
CYP17A1 protein results in increased hydroxylation of 5-alpha-Dihydroprogesterone |
CTD |
PMID:14522586 |
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NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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G |
Egr2 |
early growth response 2 |
increases expression |
EXP |
5-alpha-Dihydroprogesterone results in increased expression of EGR2 mRNA; 5-alpha-Dihydroprogesterone results in increased expression of EGR2 protein |
CTD |
PMID:17478888 |
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NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
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G |
Esr1 |
estrogen receptor 1 |
increases expression |
ISO |
5-alpha-Dihydroprogesterone results in increased expression of ESR1 mRNA |
CTD |
PMID:17683929 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
decreases expression |
EXP |
5-alpha-Dihydroprogesterone results in decreased expression of GSK3B protein |
CTD |
PMID:17443805 |
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Mapt |
microtubule-associated protein tau |
decreases expression increases phosphorylation |
EXP |
5-alpha-Dihydroprogesterone results in decreased expression of MAPT protein 5-alpha-Dihydroprogesterone results in increased phosphorylation of MAPT protein |
CTD |
PMID:17443805 |
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NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
affects activity multiple interactions |
ISO |
5-alpha-Dihydroprogesterone affects the activity of NR1I2 protein 5-alpha-Dihydroprogesterone binds to and results in increased activity of NR1I2 protein NR1I2 protein affects the susceptibility to [5-alpha-Dihydroprogesterone co-treated with Methacholine Chloride]; NR1I2 protein affects the susceptibility to [5-alpha-Dihydroprogesterone co-treated with N-methylsulfonyl-6-(2-propargyloxyphenyl)hexanamide] |
CTD |
PMID:15846226 PMID:16054614 PMID:17159084 PMID:21291553 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
increases activity |
ISO |
5-alpha-Dihydroprogesterone results in increased activity of NR1I3 protein |
CTD |
PMID:28927721 |
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NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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G |
Sox10 |
SRY-box transcription factor 10 |
increases expression |
EXP |
5-alpha-Dihydroprogesterone results in increased expression of SOX10 mRNA; 5-alpha-Dihydroprogesterone results in increased expression of SOX10 protein |
CTD |
PMID:17478888 |
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NCBI chr 7:110,725,274...110,734,651
Ensembl chr 7:110,725,274...110,735,544
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G |
Srd5a1 |
steroid 5 alpha-reductase 1 |
multiple interactions increases chemical synthesis |
ISO |
[SRD5A1 protein results in increased metabolism of Progesterone] which results in increased chemical synthesis of 5-alpha-Dihydroprogesterone SRD5A1 protein results in increased chemical synthesis of 5-alpha-Dihydroprogesterone |
CTD |
PMID:23183084 PMID:25463305 |
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NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461
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