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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:isosilybin A
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Accession:CHEBI:205528 term browser browse the term
Synonyms:exact_synonym: (2R,3R)-3,5,7-trihydroxy-2-[(2R,3R)-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydro-4H-chromen-4-one
 related_synonym: (2R,3R)-3,5,7-trihydroxy-2-[(2R,3R)-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydro-4H-1-benzopyran-4-one;   (2R,3R)-3,5,7-trihydroxy-2-[(2R,3R)-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one;   Formula=C25H22O10;   InChI=1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-18-7-12(3-5-16(18)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3/t20-,23+,24-,25-/m1/s1;   InChIKey=FDQAOULAVFHKBX-HKTJVKLFSA-N;   SMILES=[H][C@@]1(OC2=C(O[C@@H]1CO)C=C(C=C2)[C@@]1([H])OC2=C(C(O)=CC(O)=C2)C(=O)[C@@H]1O)C1=CC(OC)=C(O)C=C1
 xref: Chemspider:9235077;   KNApSAcK:C00039453;   LIPID_MAPS_instance:LMPK12140713
 xref_mesh: MESH:C523198
 xref: PMID:16631762;   PMID:17389612;   PMID:17764149;   PMID:20721970;   PMID:23116206;   PMID:23461697;   PMID:24456525;   PMID:24597776;   PMID:34318464


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isosilybin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO isosilybin A results in increased expression of ABCA1 protein CTD PMID:26729088 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO isosilybin A promotes the reaction [APOA1 protein results in increased secretion of Cholesterol] CTD PMID:26729088 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Ccna1 cyclin A1 decreases expression ISO isosilybin A results in decreased expression of CCNA1 protein CTD PMID:18435416 NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO isosilybin A results in decreased expression of CCNB1 protein CTD PMID:18435416 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO isosilybin A results in decreased expression of CCND1 protein CTD PMID:18435416 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO isosilybin A results in decreased expression of CCND3 protein CTD PMID:18435416 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO isosilybin A results in decreased expression of CCNE1 protein CTD PMID:18435416 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdc25a cell division cycle 25A decreases expression ISO isosilybin A results in decreased expression of CDC25A protein CTD PMID:18435416 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701 		JBrowse link
G Cdc25b cell division cycle 25B decreases expression ISO isosilybin A results in decreased expression of CDC25B protein CTD PMID:18435416 NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272 		JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO isosilybin A results in decreased expression of CDC25C protein CTD PMID:18435416 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO isosilybin A results in decreased expression of CDK1 protein CTD PMID:18435416 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO isosilybin A results in decreased expression of CDK2 protein CTD PMID:18435416 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO isosilybin A results in decreased expression of CDK4 protein CTD PMID:18435416 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO isosilybin A results in increased expression of CDKN1B protein CTD PMID:18435416 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Chek2 checkpoint kinase 2 increases phosphorylation ISO isosilybin A results in increased phosphorylation of CHEK2 protein CTD PMID:18435416 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Il4 interleukin 4 decreases secretion
decreases expression		 ISO isosilybin A results in decreased secretion of IL4 protein
isosilybin A results in decreased expression of IL4 mRNA		 CTD PMID:32284261 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 decreases expression
decreases secretion		 ISO isosilybin A results in decreased expression of IL5 mRNA
isosilybin A results in decreased secretion of IL5 protein		 CTD PMID:32284261 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions ISO isosilybin A binds to and results in decreased activity of PTPN1 protein CTD PMID:30160205 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Skp2 S-phase kinase associated protein 2 decreases expression ISO isosilybin A results in decreased expression of SKP2 protein CTD PMID:18435416 NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        biochemical role 19556
          apoptosis inducer 13663
            isosilybin A 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic heterocyclic compound 18874
                                  oxacycle 17906
                                    benzopyran 11972
                                      1-benzopyran 11726
                                        flavonolignan 145
                                          isosilybin A 19
paths to the root