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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5-aminoimidazole-4-carboxamide
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Accession:CHEBI:2030 term browser browse the term
Definition:An aminoimidazole in which the amino group is at C-5 with a carboxamido group at C-4.
Synonyms:related_synonym: 4-amino-1H-imidazole-5-carboxamide;   4-amino-5-carbamoylimidazole;   4-amino-5-imidazolecarboxamide;   5(4)-amino-4(5)-imidazolecarboxamide;   5-amino-4-imidazolecarboxyamide;   Formula=C4H6N4O;   InChI=1S/C4H6N4O/c5-3-2(4(6)9)7-1-8-3/h1H,5H2,(H2,6,9)(H,7,8);   InChIKey=DVNYTAVYBRSTGK-UHFFFAOYSA-N;   SMILES=NC(=O)c1nc[nH]c1N
 alt_id: CHEBI:20544
 xref: Drug_Central:1994;   HMDB:HMDB0003192;   KEGG:C04051
 xref_mesh: MESH:D000620
 xref: MetaCyc:CPD-3762;   PDBeChem:5AC;   PMID:12997251;   PMID:24402866;   Reaxys:3938


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5-aminoimidazole-4-carboxamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg1 arginase 1 multiple interactions
increases expression		 EXP Aminoimidazole Carboxamide analog promotes the reaction [Lipopolysaccharides results in increased expression of ARG1 protein]
Aminoimidazole Carboxamide analog results in increased expression of ARG1 protein		 CTD PMID:19853624 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422 		JBrowse link
G Il10 interleukin 10 increases expression
multiple interactions		 EXP Aminoimidazole Carboxamide analog results in increased expression of IL10 protein
Aminoimidazole Carboxamide analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]; dorsomorphin inhibits the reaction [Aminoimidazole Carboxamide analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]]		 CTD PMID:19853624 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Aminoimidazole Carboxamide analog promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; dorsomorphin inhibits the reaction [Aminoimidazole Carboxamide promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]] CTD PMID:19853624 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Aminoimidazole Carboxamide analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:19853624 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Aminoimidazole Carboxamide analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:19853624 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP [Aminoimidazole Carboxamide analog co-treated with Lipopolysaccharides] results in increased expression of PPARGC1A protein; Aminoimidazole Carboxamide analog promotes the reaction [Lipopolysaccharides results in increased expression of PPARGC1A protein]; dorsomorphin inhibits the reaction [Aminoimidazole Carboxamide analog promotes the reaction [Lipopolysaccharides results in increased expression of PPARGC1A protein]] CTD PMID:19853624 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP [Aminoimidazole Carboxamide analog co-treated with Lipopolysaccharides] results in increased expression of RELA protein; Aminoimidazole Carboxamide analog inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein] CTD PMID:19853624 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [Lipopolysaccharides co-treated with Aminoimidazole Carboxamide analog] results in increased expression of TGFB1 protein CTD PMID:19853624 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 EXP [dorsomorphin co-treated with Aminoimidazole Carboxamide analog] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Aminoimidazole Carboxamide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Aminoimidazole Carboxamide analog results in increased expression of TNF protein		 CTD PMID:19853624 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    chemical entity 19909
      atom 19909
        nonmetal atom 19832
          nitrogen atom 19009
            nitrogen molecular entity 18984
              organonitrogen compound 18859
                carboxamide 17580
                  monocarboxylic acid amide 15752
                    5-aminoimidazole-4-carboxamide 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            heteroorganic entity 19541
                              organochalcogen compound 19301
                                organooxygen compound 19193
                                  carbon oxoacid 18681
                                    carboxylic acid 18678
                                      carboacyl group 17728
                                        univalent carboacyl group 17728
                                          carbamoyl group 17548
                                            carboxamide 17580
                                              monocarboxylic acid amide 15752
                                                5-aminoimidazole-4-carboxamide 9
paths to the root