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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Recombinant Tumor Necrosis Factor-alpha (human)
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Accession:CHEBI:197440 term browser browse the term
Definition:TNF-alpha is released from macrophages, monocytes, neutrophils, T-cells (principally CD4+), NK-cells and many transformed cell lines. Soluble homotrimeric TNF-alpha released from cells by proteolysis of the integral membrane precursor form of TNF-alpha. TNF-alpha binding to some TNF-alpha receptors induces apoptosis and depending on cell type, receptor expression, and signal transduction status can induce other responses. TNF-a is involved in the inflammatory response.
Synonyms:related_synonym: Cachectin;   Differentiation inducing factor (DIF);   Macrophage cytotoxic factor (MCF);   Necrosin;   TNFSF2;   Tumor necrosis factor-alpha



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Recombinant Tumor Necrosis Factor-alpha (human) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acod1 aconitate decarboxylase 1 increases expression ISO TNF increases expression of Acod1 mRNA in human macrophage cultures RGD PMID:28699638 RGD:596948428 NCBI chr15:79,871,819...79,881,101 JBrowse link

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  CHEBI ontology 19898
    chemical entity 19896
      atom 19896
        nonmetal atom 19818
          carbon atom 19770
            organic molecular entity 19770
              Recombinant Tumor Necrosis Factor-alpha (human) 1
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  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            Recombinant Tumor Necrosis Factor-alpha (human) 1
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