Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:mocetinostat
go back to main search page
Accession:CHEBI:197437 term browser browse the term
Definition:A benzamide obtained by formal condensation of the carboxy group of 4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an orally active and isotype-selective HDAC inhibitor which exhibits antitumour activity (IC50 = 0.15, 0.29, 1.66 and 0.59 muM for HDAC1, HDAC2, HDAC3 and HDAC11).
Synonyms:exact_synonym: N-(2-aminophenyl)-4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzamide
 related_synonym: Formula=C23H20N6O;   InChI=1S/C23H20N6O/c24-19-5-1-2-6-21(19)28-22(30)17-9-7-16(8-10-17)14-27-23-26-13-11-20(29-23)18-4-3-12-25-15-18/h1-13,15H,14,24H2,(H,28,30)(H,26,27,29);   InChIKey=HRNLUBSXIHFDHP-UHFFFAOYSA-N;   MG 0103;   MGCD-0103;   MGCD0103;   N-(2-aminophenyl)-4-[[[4-(3-pyridinyl)-2-pyrimidinyl]amino]methyl]benzamide;   SMILES=NC1=C(NC(=O)C2=CC=C(CNC3=NC=CC(=N3)C3=CN=CC=C3)C=C2)C=CC=C1;   mocetinostatum
 alt_id: CHEBI:94525
 xref: CAS:726169-73-9;   DrugBank:DB11830;   HMDB:HMDB0254820;   KEGG:D09641;   LINCS:LSM-5344
 xref_mesh: MESH:C523184
 xref: PMID:17621879;   PMID:21554162;   PMID:22033282;   PMID:24588344;   PMID:26357656;   PMID:26464683;   PMID:28440559;   PMID:29186204;   PMID:29238851;   PMID:29978554;   PMID:30344659;   PMID:30473623;   PMID:30551546;   PMID:30570744;   PMID:31534435;   PMID:32194803;   PMID:32373984;   PMID:34002805;   PMID:34565105;   PMID:34983914;   PMID:35317122;   PMID:35678233;   PMID:36642966;   PMID:36890020;   PMID:37681413;   PMID:37759078;   Wikipedia:Mocetinostat


show annotations for term's descendants           Sort by:
mocetinostat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd274 CD274 molecule increases expression ISO mocetinostat results in increased expression of CD274 protein CTD PMID:26775640 NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450 		JBrowse link
G Cd69 Cd69 molecule multiple interactions ISO mocetinostat inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of CD69 protein] CTD PMID:24200994 NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542 		JBrowse link
G Cdca8 cell division cycle associated 8 decreases expression ISO mocetinostat results in decreased expression of CDCA8 mRNA CTD PMID:26378038 NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO mocetinostat results in decreased expression of CDK1 mRNA CTD PMID:26378038 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 increases expression ISO mocetinostat results in increased expression of ERRFI1 mRNA CTD PMID:33770205 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282 		JBrowse link
G Gpr183 G protein-coupled receptor 183 decreases expression ISO mocetinostat results in decreased expression of GPR183 mRNA CTD PMID:33770205 NCBI chr15:99,037,764...99,050,550
Ensembl chr15:99,036,367...99,050,559 		JBrowse link
G H3f4 H3.4 histone, cluster member increases acetylation ISO mocetinostat results in increased acetylation of H3-4 protein CTD PMID:19215824 NCBI chr10:43,740,702...43,741,262 JBrowse link
G Hdac1 histone deacetylase 1 decreases expression ISO mocetinostat results in decreased expression of HDAC1 protein CTD PMID:26378038 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hdac2 histone deacetylase 2 decreases expression ISO mocetinostat results in decreased expression of HDAC2 protein CTD PMID:26378038 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hdac3 histone deacetylase 3 decreases expression ISO mocetinostat results in decreased expression of HDAC3 protein CTD PMID:26378038 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856 		JBrowse link
G Ifng interferon gamma multiple interactions ISO mocetinostat inhibits the reaction [enterotoxin B, staphylococcal results in increased secretion of IFNG protein] CTD PMID:24200994 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO mocetinostat inhibits the reaction [enterotoxin B, staphylococcal results in increased secretion of IL2 protein] CTD PMID:24200994 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO mocetinostat inhibits the reaction [enterotoxin B, staphylococcal results in increased secretion of IL6 protein] CTD PMID:24200994 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [mocetinostat co-treated with (+)-JQ1 compound] results in decreased phosphorylation of MAPK1 protein CTD PMID:26378038 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [mocetinostat co-treated with (+)-JQ1 compound] results in decreased phosphorylation of MAPK3 protein CTD PMID:26378038 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Neu1 neuraminidase 1 decreases expression ISO mocetinostat results in decreased expression of NEU1 mRNA CTD PMID:33770205 NCBI chr20:3,897,480...3,901,745
Ensembl chr20:3,897,480...3,901,745 		JBrowse link
G Potem POTE ankyrin domain family member M increases expression ISO mocetinostat results in increased expression of POTEM mRNA CTD PMID:33770205 NCBI chr16:20,193,646...20,311,924
Ensembl chr16:19,949,230...19,976,541 		JBrowse link
G Psd3 pleckstrin and Sec7 domain containing 3 increases expression ISO mocetinostat results in increased expression of PSD3 mRNA CTD PMID:33770205 NCBI chr16:21,465,643...22,035,846
Ensembl chr16:21,465,639...22,034,547 		JBrowse link
G Ralgdsl1 ral guanine nucleotide dissociation stimulator like 1 increases expression ISO mocetinostat results in increased expression of RGL1 mRNA CTD PMID:33770205 NCBI chr13:64,634,489...64,904,170
Ensembl chr13:64,635,246...64,904,191 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases acetylation ISO mocetinostat results in increased acetylation of STAT3 protein CTD PMID:26775640 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tmcc3 transmembrane and coiled-coil domain family 3 increases expression ISO mocetinostat results in increased expression of TMCC3 mRNA CTD PMID:33770205 NCBI chr 7:28,893,972...29,171,935
Ensembl chr 7:28,893,967...29,171,926 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO mocetinostat inhibits the reaction [enterotoxin B, staphylococcal results in increased secretion of TNF protein] CTD PMID:24200994 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tpcn1 two pore segment channel 1 increases expression ISO mocetinostat results in increased expression of TPCN1 mRNA CTD PMID:33770205 NCBI chr12:35,972,813...36,029,632
Ensembl chr12:35,972,846...36,029,626 		JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase increases expression ISO mocetinostat results in increased expression of UGCG mRNA CTD PMID:33770205 NCBI chr 5:74,032,978...74,065,701
Ensembl chr 5:74,032,978...74,065,393 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        biochemical role 19582
          autophagy inducer 2071
            mocetinostat 24
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            heteroorganic entity 19541
                              organochalcogen compound 19301
                                organooxygen compound 19193
                                  carbon oxoacid 18681
                                    carboxylic acid 18678
                                      carboacyl group 17728
                                        univalent carboacyl group 17728
                                          carbamoyl group 17548
                                            carboxamide 17580
                                              monocarboxylic acid amide 15752
                                                arenecarboxamide 8259
                                                  benzamides 8259
                                                    mocetinostat 24
paths to the root