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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:SB 290157
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Accession:CHEBI:197424 term browser browse the term
Definition:Antagonist of C3aR
Synonyms:exact_synonym: N(2)-[(2,2-diphenylethoxy)acetyl]-L-arginine trifluoroacetate
 related_synonym: Formula=C22H28N4O4.C2HF3O2;   InChI=1S/C22H28N4O4.C2HF3O2/c23-22(24)25-13-7-12-19(21(28)29)26-20(27)15-30-14-18(16-8-3-1-4-9-16)17-10-5-2-6-11-17;3-2(4,5)1(6)7/h1-6,8-11,18-19H,7,12-15H2,(H,26,27)(H,28,29)(H4,23,24,25);(H,6,7)/t19-;/m0./s1;   InChIKey=ZJRMPPVJAQWGEG-FYZYNONXSA-N;   N(2)-[2-(2,2-Diphenylethoxy)acetyl]-L-arginine trifluoroacetate salt;   N2-[2-(2,2-diphenylethoxy)acetyl]-L-arginine, 2,2,2-trifluoroacetate;   SB 290157 trifluoroacetate salt;   SB290157;   SB290157 trifluoroacetate;   SMILES=OC(=O)C(F)(F)F.NC(=N)NCCCC(NC(=O)COCC(C1=CC=CC=C1)C1=CC=CC=C1)C(O)=O
 xref: CAS:1140525-25-2
 xref_mesh: MESH:C431907
 xref: PMID:11342658;   PMID:15944244;   PMID:16154494;   PMID:20051658;   PMID:33073351;   PMID:33551801


show annotations for term's descendants           Sort by:
SB 290157 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3ar1 complement C3a receptor 1 multiple interactions
decreases activity 		ISO SB 290157 inhibits the reaction [Trichloroethylene results in increased expression of C3AR1 protein]
SB 290157 results in decreased activity of C3AR1 protein 		CTD PMID:24974766 PMID:32898628 NCBI chr 4:157,747,419...157,756,609
Ensembl chr 4:157,746,089...157,776,323 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO SB 290157 inhibits the reaction [aristolochic acid I results in decreased expression of CDH1 protein] CTD PMID:32898628 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO SB 290157 inhibits the reaction [aristolochic acid I results in increased expression of CDH2 protein] CTD PMID:32898628 NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO SB 290157 inhibits the reaction [Trichloroethylene results in increased expression of IL4 protein] CTD PMID:24974766 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO SB 290157 inhibits the reaction [aristolochic acid I results in increased secretion of IL6 protein] CTD PMID:37084829 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO SB 290157 inhibits the reaction [aristolochic acid I results in increased expression of MMP9 mRNA]; SB 290157 inhibits the reaction [aristolochic acid I results in increased expression of MMP9 protein] CTD PMID:37084829 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO SB 290157 inhibits the reaction [aristolochic acid I results in increased expression of RELA mRNA]; SB 290157 inhibits the reaction [aristolochic acid I results in increased expression of RELA protein] CTD PMID:37084829 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Vim vimentin multiple interactions ISO SB 290157 inhibits the reaction [aristolochic acid I results in increased expression of VIM protein] CTD PMID:32898628 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20849
    chemical entity 20860
      atom 20860
        nonmetal atom 20766
          carbon atom 20710
            organic molecular entity 20710
              SB 290157 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 20849
    subatomic particle 20847
      composite particle 20860
        hadron 20847
          baryon 20860
            nucleon 20847
              atomic nucleus 20847
                atom 20860
                  main group element atom 20781
                    p-block element atom 20768
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            SB 290157 8
paths to the root