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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
multiple interactions increases export |
EXP |
[Epinephrine co-treated with [verlukast results in decreased activity of ABCC1 protein]] results in increased abundance of Glutathione Disulfide; [verlukast results in decreased activity of ABCC1 protein] which promotes the reaction and affects the abundance of Epinephrine metabolite ABCC1 protein results in increased export of Epinephrine metabolite |
CTD |
PMID:19053318 |
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NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114
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G |
Aco2 |
aconitase 2 |
increases expression |
EXP |
Epinephrine results in increased expression of ACO2 protein |
CTD |
PMID:19464573 |
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NCBI chr 7:115,265,816...115,308,931
Ensembl chr 7:113,385,646...113,428,261
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G |
Actn1 |
actinin, alpha 1 |
increases expression |
EXP |
Epinephrine results in increased expression of ACTN1 protein |
CTD |
PMID:19464573 |
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NCBI chr 6:104,731,485...104,826,312
Ensembl chr 6:98,998,556...99,093,251
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
multiple interactions decreases expression |
EXP |
Sildenafil Citrate inhibits the reaction [Epinephrine results in decreased expression of ADIPOQ protein]; Tadalafil inhibits the reaction [Epinephrine results in decreased expression of ADIPOQ protein] |
CTD |
PMID:29233027 |
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NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564
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G |
Adra1a |
adrenoceptor alpha 1A |
multiple interactions affects binding increases activity |
EXP ISO |
[Epinephrine binds to and results in increased activity of ADRA1A protein] which results in increased transport of Calcium; Epinephrine binds to and results in increased activity of ADRA1A protein Epinephrine binds to ADRA1A protein [Epinephrine binds to and results in increased activity of ADRA1A protein] which results in increased abundance of Calcium; [Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; Epinephrine binds to and results in increased activity of ADRA1A protein; Epinephrine inhibits the reaction [ADRA1A protein binds to Prazosin]; Phentolamine inhibits the reaction [[Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium] |
CTD |
PMID:8183249 PMID:15306222 PMID:15672411 PMID:20030735 |
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NCBI chr15:45,005,648...45,111,416
Ensembl chr15:40,832,534...40,927,500
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G |
Adra1b |
adrenoceptor alpha 1B |
multiple interactions increases activity |
ISO |
[Epinephrine binds to and results in increased activity of ADRA1B protein] which results in increased abundance of Calcium; [Epinephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium]; Epinephrine binds to and results in increased activity of ADRA1B protein; Epinephrine inhibits the reaction [ADRA1B protein binds to Prazosin]; Phentolamine inhibits the reaction [[Epinephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium] |
CTD |
PMID:15306222 PMID:20030735 |
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NCBI chr10:28,756,461...28,874,831
Ensembl chr10:28,255,025...28,312,919
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G |
Adra1d |
adrenoceptor alpha 1D |
affects binding multiple interactions increases activity |
ISO |
Epinephrine binds to ADRA1D protein [Epinephrine binds to and results in increased activity of ADRA1D protein] which results in increased abundance of Calcium; [Epinephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium; Carvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium]; Epinephrine binds to and results in increased activity of ADRA1D protein; Epinephrine inhibits the reaction [ADRA1D protein binds to Prazosin]; Phentolamine inhibits the reaction [[Epinephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium] |
CTD |
PMID:8183249 PMID:15306222 PMID:20030735 |
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NCBI chr 3:139,246,333...139,262,331
Ensembl chr 3:118,793,346...118,809,354
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G |
Adra2a |
adrenoceptor alpha 2A |
increases activity multiple interactions |
EXP ISO |
Epinephrine results in increased activity of ADRA2A protein [Epinephrine binds to and results in increased activity of ADRA2A protein] which results in increased abundance of Calcium; ADRA2A promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; Epinephrine binds to and results in increased activity of ADRA2A protein; Epinephrine inhibits the reaction [ADRA2A protein binds to 2-methoxyidazoxan] Epinephrine promotes the reaction [GNB2 protein binds to ADRA2A protein]; Epinephrine promotes the reaction [GNB4 protein binds to ADRA2A protein]; Epinephrine promotes the reaction [GNG12 protein binds to ADRA2A protein]; Epinephrine promotes the reaction [GNG2 protein binds to ADRA2A protein]; Epinephrine promotes the reaction [GNG3 protein binds to ADRA2A protein]; Epinephrine promotes the reaction [GNG4 protein binds to ADRA2A protein] |
CTD |
PMID:17341653 PMID:17680988 PMID:20030735 PMID:30737458 |
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NCBI chr 1:263,066,780...263,069,580
Ensembl chr 1:253,060,218...253,064,365
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G |
Adra2b |
adrenoceptor alpha 2B |
multiple interactions |
ISO |
[Epinephrine binds to and results in increased activity of ADRA2B protein] which results in increased abundance of Calcium; ADRA2B promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; Epinephrine binds to and results in increased activity of ADRA2B protein; Epinephrine inhibits the reaction [ADRA2B protein binds to 2-methoxyidazoxan] |
CTD |
PMID:17680988 PMID:20030735 |
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NCBI chr 3:135,038,481...135,042,527
Ensembl chr 3:114,585,169...114,589,355
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G |
Adra2c |
adrenoceptor alpha 2C |
multiple interactions |
ISO |
[Epinephrine binds to and results in increased activity of ADRA2C protein] which results in increased abundance of Calcium; ADRA2C promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; Epinephrine binds to and results in increased activity of ADRA2C protein; Epinephrine inhibits the reaction [ADRA2C protein binds to 2-methoxyidazoxan] |
CTD |
PMID:17680988 PMID:20030735 |
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NCBI chr14:79,695,514...79,697,476
Ensembl chr14:75,471,143...75,472,846
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G |
Adrb1 |
adrenoceptor beta 1 |
multiple interactions |
ISO EXP |
[CGP 20712A binds to and results in decreased activity of ADRB1 protein] which results in decreased activity of Epinephrine [Epinephrine binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP; Epinephrine binds to and results in increased activity of ADRB1 protein; Epinephrine inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Epinephrine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein] |
CTD |
PMID:8096834 PMID:12010770 PMID:14730417 |
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NCBI chr 1:265,777,103...265,780,114
Ensembl chr 1:255,771,597...255,807,259
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G |
Adrb2 |
adrenoceptor beta 2 |
multiple interactions increases activity affects response to substance |
ISO EXP |
[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; Atenolol inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]; carvedilol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]; Epinephrine binds to and results in increased activity of ADRB2 protein; Epinephrine inhibits the reaction [cyanopindolol binds to ADRB2 protein]; Epinephrine promotes the reaction [GRK2 protein results in increased phosphorylation of ADRB2 protein]; Epinephrine promotes the reaction [GRK5 protein results in increased phosphorylation of ADRB2 protein]; Epinephrine results in increased phosphorylation of and results in increased localization of ADRB2 protein; ICI 118551 inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; ICI 118551 inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]; Propranolol inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Propranolol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein] Epinephrine results in increased activity of ADRB2 protein ADRB2 affects the susceptibility to Epinephrine [Epinephrine results in increased activity of ADRB2 protein] which results in increased secretion of Histamine |
CTD |
PMID:1389726 PMID:11164953 PMID:12920204 PMID:14722251 PMID:14730417 PMID:16026475 PMID:16225854 PMID:34601065 More...
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NCBI chr18:57,912,760...57,914,802
Ensembl chr18:55,502,903...55,644,512
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G |
Adrb3 |
adrenoceptor beta 3 |
multiple interactions |
EXP ISO |
Epinephrine binds to and results in increased activity of ADRB3 protein [Epinephrine binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP; Epinephrine binds to and results in increased activity of ADRB3 protein; Epinephrine inhibits the reaction [cyanopindolol binds to ADRB3 protein] |
CTD |
PMID:1682311 PMID:7815362 PMID:14730417 |
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NCBI chr16:71,544,603...71,547,410
Ensembl chr16:64,841,788...64,844,552
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G |
Ak2 |
adenylate kinase 2 |
decreases expression multiple interactions |
EXP |
Epinephrine results in decreased expression of AK2 protein [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of AK2 protein |
CTD |
PMID:19464573 |
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NCBI chr 5:146,609,469...146,649,008
Ensembl chr 5:141,346,063...141,364,632
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
[Epinephrine co-treated with INS protein] results in increased phosphorylation of AKT1 protein |
CTD |
PMID:32305330 |
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NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
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G |
Aoc1 |
amine oxidase, copper containing 1 |
multiple interactions increases activity |
EXP |
Cycloheximide inhibits the reaction [Epinephrine results in increased activity of AOC1 protein]; Dactinomycin inhibits the reaction [Epinephrine results in increased activity of AOC1 protein]; Timolol inhibits the reaction [Epinephrine results in increased activity of AOC1 protein] |
CTD |
PMID:2860926 |
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NCBI chr 4:79,143,126...79,162,705
Ensembl chr 4:77,812,260...77,831,840
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G |
Aqp7 |
aquaporin 7 |
affects localization increases expression multiple interactions |
ISO |
Epinephrine affects the localization of AQP7 protein Epinephrine results in increased expression of AQP7 mRNA INS1 inhibits the reaction [Epinephrine results in increased expression of AQP7 mRNA] |
CTD |
PMID:10777495 |
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NCBI chr 5:60,968,495...60,982,618
Ensembl chr 5:56,172,519...56,186,642
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G |
Atp5f1a |
ATP synthase F1 subunit alpha |
increases expression |
EXP |
Epinephrine results in increased expression of ATP5F1A protein |
CTD |
PMID:19464573 |
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NCBI chr18:73,567,537...73,575,473
Ensembl chr18:71,292,374...71,300,794
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G |
Bcl2 |
BCL2, apoptosis regulator |
increases expression |
ISO |
Epinephrine results in increased expression of BCL2 protein |
CTD |
PMID:36423730 |
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NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bmp2 |
bone morphogenetic protein 2 |
decreases expression |
ISO |
Epinephrine results in decreased expression of BMP2 mRNA; Epinephrine results in decreased expression of BMP2 protein |
CTD |
PMID:31520687 |
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NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:120,812,882...120,821,397
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G |
C1qbp |
complement C1q binding protein |
multiple interactions increases expression |
EXP |
[Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of C1QBP protein Epinephrine results in increased expression of C1QBP protein |
CTD |
PMID:19464573 |
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NCBI chr10:56,198,534...56,203,185
Ensembl chr10:55,699,954...55,704,649
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G |
Calca |
calcitonin-related polypeptide alpha |
increases abundance |
EXP |
CALCA protein results in increased abundance of Epinephrine |
CTD |
PMID:8058111 |
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NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:168,878,214...168,883,105
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G |
Caly |
calcyon neuron-specific vesicular protein |
decreases secretion |
ISO |
CALY protein results in decreased secretion of Epinephrine |
CTD |
PMID:30753204 |
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NCBI chr 1:194,862,671...194,873,861
Ensembl chr 1:194,862,672...194,873,551
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G |
Car2 |
carbonic anhydrase 2 |
increases expression |
ISO |
Epinephrine results in increased expression of CA2 mRNA |
CTD |
PMID:12729923 |
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NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:86,741,626...86,756,818
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G |
Casp3 |
caspase 3 |
multiple interactions increases activity increases expression |
ISO EXP |
Atenolol inhibits the reaction [Epinephrine results in increased activity of CASP3 protein]; carvedilol inhibits the reaction [Epinephrine results in increased activity of CASP3 protein] Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of CASP3 protein]; Sildenafil Citrate inhibits the reaction [Epinephrine results in increased expression of CASP3 protein]; Tadalafil inhibits the reaction [Epinephrine results in increased expression of CASP3 protein]; Vardenafil Dihydrochloride inhibits the reaction [Epinephrine results in increased expression of CASP3 protein] |
CTD |
PMID:10728402 PMID:19135123 PMID:29233027 |
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NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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G |
Cat |
catalase |
decreases response to substance |
ISO |
CAT results in decreased susceptibility to Epinephrine |
CTD |
PMID:25172298 |
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NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
multiple interactions |
ISO |
Epinephrine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL3 mRNA]; Epinephrine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL3 protein]; Propranolol inhibits the reaction [Epinephrine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL3 protein]] Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA]; Epinephrine inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]; Epinephrine inhibits the reaction [Thioglycolates results in increased secretion of CCL3 protein] |
CTD |
PMID:9863660 PMID:12538206 |
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NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,451,388...68,452,938
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G |
Ccnd1 |
cyclin D1 |
multiple interactions increases expression |
EXP ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; 2-methoxyidazoxan inhibits the reaction [Epinephrine results in increased expression of CCND1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Epinephrine results in increased expression of CCND1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Epinephrine results in increased expression of CCND1 protein]; Niclosamide inhibits the reaction [Epinephrine results in increased expression of CCND1 mRNA] ADRA2A promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased expression of CCND1 protein] Epinephrine results in increased expression of CCND1 mRNA; Epinephrine results in increased expression of CCND1 protein |
CTD |
PMID:17680988 PMID:26964897 |
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NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
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G |
Cebpb |
CCAAT/enhancer binding protein beta |
decreases expression |
ISO |
Epinephrine results in decreased expression of CEBPB protein |
CTD |
PMID:31520687 |
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NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:156,397,052...156,399,473
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G |
Chrna7 |
cholinergic receptor nicotinic alpha 7 subunit |
multiple interactions |
ISO |
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased abundance of Epinephrine] |
CTD |
PMID:17498763 |
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NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240
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G |
Comt |
catechol-O-methyltransferase |
increases methylation multiple interactions |
ISO EXP |
COMT protein results in increased methylation of Epinephrine [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Epinephrine [COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine; tolcapone inhibits the reaction [[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine] |
CTD |
PMID:8821542 PMID:10064789 PMID:11160877 PMID:11248589 |
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NCBI chr11:96,072,371...96,091,956
Ensembl chr11:82,568,025...82,587,642
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions increases phosphorylation |
ISO EXP |
ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein] 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; Dietary Fats promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; Epinephrine promotes the reaction [Dietary Fats results in increased phosphorylation of CREB1 protein]; Ketoconazole inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein] |
CTD |
PMID:17680988 PMID:22496244 |
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NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816
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G |
Crh |
corticotropin releasing hormone |
multiple interactions increases abundance |
EXP |
corticotropin releasing hormone (9-41) inhibits the reaction [CRH protein affects the abundance of Epinephrine] CRH results in increased abundance of Epinephrine |
CTD |
PMID:1320258 |
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NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:102,143,055...102,144,919
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G |
Csk |
C-terminal Src kinase |
multiple interactions |
ISO |
CSK protein promotes the reaction [Epinephrine results in increased abundance of Cyclic AMP]; Isoproterenol inhibits the reaction [CSK protein promotes the reaction [Epinephrine results in increased abundance of Cyclic AMP]] |
CTD |
PMID:1699227 |
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NCBI chr 8:66,925,650...66,944,861
Ensembl chr 8:58,029,749...58,048,292
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G |
Ctnnb1 |
catenin beta 1 |
increases phosphorylation multiple interactions |
EXP |
Epinephrine results in increased phosphorylation of CTNNB1 protein N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Epinephrine results in increased phosphorylation of CTNNB1 protein]; Niclosamide inhibits the reaction [Epinephrine results in increased phosphorylation of CTNNB1 protein] |
CTD |
PMID:26964897 |
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NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111
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G |
Ctsk |
cathepsin K |
increases expression |
ISO |
Epinephrine results in increased expression of CTSK mRNA |
CTD |
PMID:12729923 |
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NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:183,058,569...183,069,550
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G |
Cycs |
cytochrome c, somatic |
multiple interactions increases expression |
EXP |
[Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of CYCS protein Epinephrine results in increased expression of CYCS protein |
CTD |
PMID:19464573 |
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NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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G |
Dbh |
dopamine beta-hydroxylase |
affects abundance |
ISO |
DBH gene polymorphism affects the abundance of Epinephrine |
CTD |
PMID:16163519 |
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NCBI chr 3:30,886,313...30,903,313
Ensembl chr 3:10,488,260...10,505,248
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G |
Des |
desmin |
multiple interactions decreases expression |
EXP |
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of DES protein Epinephrine results in decreased expression of DES protein |
CTD |
PMID:19464573 |
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NCBI chr 9:84,299,626...84,307,344
Ensembl chr 9:76,850,982...76,858,699
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G |
Dlat |
dihydrolipoamide S-acetyltransferase |
multiple interactions |
EXP |
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of DLAT protein |
CTD |
PMID:19464573 |
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NCBI chr 8:59,875,537...59,900,947
Ensembl chr 8:50,978,051...51,004,479 Ensembl chr 1:50,978,051...51,004,479
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G |
Echs1 |
enoyl-CoA hydratase, short chain 1 |
multiple interactions |
EXP |
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ECHS1 protein |
CTD |
PMID:19464573 |
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NCBI chr 1:204,324,679...204,333,506
Ensembl chr 1:194,895,036...194,903,884
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G |
Epha4 |
Eph receptor A4 |
increases phosphorylation |
ISO |
Epinephrine results in increased phosphorylation of EPHA4 protein |
CTD |
PMID:22273509 |
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NCBI chr 9:86,263,982...86,406,744
Ensembl chr 9:78,815,460...78,958,139
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G |
Etfb |
electron transfer flavoprotein subunit beta |
multiple interactions |
EXP |
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ETFB protein |
CTD |
PMID:19464573 |
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NCBI chr 1:102,988,499...103,002,663
Ensembl chr 1:93,851,858...93,866,068
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G |
Fabp3 |
fatty acid binding protein 3 |
affects expression multiple interactions |
EXP |
Epinephrine affects the expression of FABP3 protein [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of FABP3 protein |
CTD |
PMID:19464573 |
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NCBI chr 5:147,936,027...147,942,870
Ensembl chr 5:142,651,956...142,658,718
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G |
Fas |
Fas cell surface death receptor |
multiple interactions increases expression |
ISO |
Atenolol inhibits the reaction [Epinephrine results in increased expression of FAS protein]; carvedilol inhibits the reaction [Epinephrine results in increased expression of FAS protein] |
CTD |
PMID:10728402 |
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NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591
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G |
Faslg |
Fas ligand |
multiple interactions increases expression |
ISO |
Atenolol inhibits the reaction [Epinephrine results in increased expression of FASLG protein]; carvedilol inhibits the reaction [Epinephrine results in increased expression of FASLG protein] |
CTD |
PMID:10728402 |
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NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215
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G |
Fh |
fumarate hydratase |
increases expression |
EXP |
Epinephrine results in increased expression of FH protein |
CTD |
PMID:19464573 |
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NCBI chr13:90,056,565...90,082,450
Ensembl chr13:87,524,337...87,550,266
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G |
Foxo1 |
forkhead box O1 |
decreases expression |
ISO |
Epinephrine results in decreased expression of FOXO1 protein |
CTD |
PMID:31520687 |
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NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:136,312,168...136,387,790
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G |
Gnb2 |
G protein subunit beta 2 |
multiple interactions |
ISO |
Epinephrine promotes the reaction [GNB2 protein binds to ADRA2A protein] |
CTD |
PMID:30737458 |
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NCBI chr12:24,795,505...24,800,796
Ensembl chr12:19,158,973...19,164,019
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G |
Gnb4 |
G protein subunit beta 4 |
multiple interactions |
ISO |
Epinephrine promotes the reaction [GNB4 protein binds to ADRA2A protein] |
CTD |
PMID:30737458 |
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NCBI chr 2:115,360,746...115,400,680
Ensembl chr 2:115,364,918...115,400,579
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G |
Gng12 |
G protein subunit gamma 12 |
multiple interactions |
ISO |
Epinephrine promotes the reaction [GNG12 protein binds to ADRA2A protein] |
CTD |
PMID:30737458 |
|
NCBI chr 4:97,340,830...97,464,422
Ensembl chr 4:96,010,952...96,134,712
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G |
Gng2 |
G protein subunit gamma 2 |
multiple interactions |
ISO |
Epinephrine promotes the reaction [GNG2 protein binds to ADRA2A protein] |
CTD |
PMID:30737458 |
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NCBI chr15:4,365,222...4,466,060
Ensembl chr15:4,316,059...4,417,183
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G |
Gng3 |
G protein subunit gamma 3 |
multiple interactions |
ISO |
Epinephrine promotes the reaction [GNG3 protein binds to ADRA2A protein] |
CTD |
PMID:30737458 |
|
NCBI chr 1:215,160,952...215,162,718
Ensembl chr 1:205,731,837...205,733,603
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G |
Gng4 |
G protein subunit gamma 4 |
multiple interactions |
ISO |
Epinephrine promotes the reaction [GNG4 protein binds to ADRA2A protein] |
CTD |
PMID:30737458 |
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NCBI chr17:93,432,791...93,481,709
Ensembl chr17:86,449,022...86,495,254
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G |
Grk2 |
G protein-coupled receptor kinase 2 |
multiple interactions |
ISO |
Epinephrine promotes the reaction [GRK2 protein results in increased phosphorylation of ADRB2 protein] |
CTD |
PMID:14722251 |
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NCBI chr 1:211,010,259...211,031,013
Ensembl chr 1:201,581,480...201,601,582
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G |
Grk5 |
G protein-coupled receptor kinase 5 |
multiple interactions |
ISO |
Epinephrine promotes the reaction [GRK5 protein results in increased phosphorylation of ADRB2 protein] |
CTD |
PMID:14722251 |
|
NCBI chr 1:270,014,314...270,208,294
Ensembl chr 1:260,028,242...260,218,701
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G |
Hadh |
hydroxyacyl-CoA dehydrogenase |
multiple interactions |
EXP |
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HADH protein |
CTD |
PMID:19464573 |
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NCBI chr 2:222,462,049...222,504,446
Ensembl chr 2:219,787,927...219,830,353
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
increases expression |
ISO |
Epinephrine results in increased expression of HIF1A protein |
CTD |
PMID:36423730 |
|
NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261
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G |
Hk2 |
hexokinase 2 |
increases expression |
ISO |
Epinephrine results in increased expression of HK2 protein |
CTD |
PMID:36423730 |
|
NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:115,234,509...115,283,530
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G |
Hsf1 |
heat shock transcription factor 1 |
multiple interactions affects localization |
EXP |
Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] affects the localization of HSF1 protein] Epinephrine affects the localization of HSF1 protein |
CTD |
PMID:19135123 |
|
NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:108,196,056...108,223,011
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G |
Hsp90ab1 |
heat shock protein 90 alpha family class B member 1 |
multiple interactions |
EXP |
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSP90AB1 protein |
CTD |
PMID:19464573 |
|
NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:15,433,691...15,438,488
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions |
EXP |
[Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of HSPA5 protein |
CTD |
PMID:19464573 |
|
NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
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G |
Hspa8 |
heat shock protein family A (Hsp70) member 8 |
increases expression |
EXP |
Epinephrine results in increased expression of HSPA8 protein |
CTD |
PMID:19464573 |
|
NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:41,183,264...41,187,259
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G |
Hspa9 |
heat shock protein family A (Hsp70) member 9 |
multiple interactions |
EXP |
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSPA9 protein |
CTD |
PMID:19464573 |
|
NCBI chr18:26,810,004...26,832,958
Ensembl chr18:26,535,798...26,554,292
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G |
Hspb6 |
heat shock protein family B (small) member 6 |
decreases expression multiple interactions |
EXP |
Epinephrine results in decreased expression of HSPB6 protein [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSPB6 protein |
CTD |
PMID:19464573 |
|
NCBI chr 1:85,806,898...85,809,072
Ensembl chr 1:85,806,146...85,809,071
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G |
Idh2 |
isocitrate dehydrogenase (NADP(+)) 2 |
decreases expression multiple interactions |
EXP |
Epinephrine results in decreased expression of IDH2 protein [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of IDH2 protein |
CTD |
PMID:19464573 |
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NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:134,029,772...134,058,025
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G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
Epinephrine promotes the reaction [Lipopolysaccharides results in increased expression of IL10 protein] |
CTD |
PMID:10588509 |
|
NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] |
CTD |
PMID:10588509 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
decreases expression multiple interactions |
EXP ISO |
Epinephrine results in decreased expression of IL6 mRNA Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] |
CTD |
PMID:10588509 PMID:12423672 |
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NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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G |
Ins1 |
insulin 1 |
multiple interactions |
ISO EXP |
INS1 inhibits the reaction [Epinephrine results in increased expression of AQP7 mRNA] cilostamide inhibits the reaction [INS1 protein inhibits the reaction [Epinephrine results in increased transport of Fatty Acids, Nonesterified]]; Cytochalasin B inhibits the reaction [INS1 protein inhibits the reaction [Epinephrine results in increased transport of Fatty Acids, Nonesterified]]; hydroxy-2-naphthalenyl-methyl phosphonic acid trisacetoxymethylester inhibits the reaction [INS1 protein inhibits the reaction [Epinephrine results in increased transport of Fatty Acids, Nonesterified]]; INS1 protein inhibits the reaction [Epinephrine results in increased transport of Fatty Acids, Nonesterified]; Wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Epinephrine results in increased transport of Fatty Acids, Nonesterified]] |
CTD |
PMID:10777495 PMID:15172182 |
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NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536
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G |
Ins2 |
insulin 2 |
multiple interactions decreases expression |
ISO |
[Epinephrine co-treated with INS protein] results in increased phosphorylation of AKT1 protein; Butoxamine inhibits the reaction [Epinephrine results in decreased expression of INS protein]; Pentolinium Tartrate inhibits the reaction [Epinephrine results in decreased secretion of INS protein]; Propranolol inhibits the reaction [Epinephrine results in decreased expression of INS protein] |
CTD |
PMID:1218171 PMID:6018752 PMID:6314140 PMID:32305330 |
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NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775
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G |
Itga2 |
integrin subunit alpha 2 |
multiple interactions |
ISO |
ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Epinephrine] |
CTD |
PMID:16214444 |
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NCBI chr 2:48,253,412...48,354,509
Ensembl chr 2:46,523,948...46,621,481
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G |
Itgav |
integrin subunit alpha V |
increases expression |
ISO |
Epinephrine results in increased expression of ITGAV mRNA |
CTD |
PMID:12729923 |
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NCBI chr 3:89,245,382...89,333,512
Ensembl chr 3:68,838,189...68,926,639
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G |
Itgb1 |
integrin subunit beta 1 |
increases response to substance |
EXP |
ITGB1 results in increased susceptibility to Epinephrine |
CTD |
PMID:14984413 |
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NCBI chr19:73,602,277...73,650,271
Ensembl chr19:56,705,171...56,753,195
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G |
Lipe |
lipase E, hormone sensitive type |
multiple interactions increases activity affects localization increases expression |
ISO EXP |
Theophylline inhibits the reaction [Epinephrine results in increased activity of LIPE protein] Epinephrine affects the localization of LIPE protein Epinephrine results in increased expression of LIPE mRNA |
CTD |
PMID:7155675 PMID:10777495 PMID:11160373 |
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NCBI chr 1:90,093,433...90,112,117
Ensembl chr 1:80,965,627...80,984,310
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions affects activity increases activity increases phosphorylation |
ISO EXP |
ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; Epinephrine inhibits the reaction [Estradiol results in decreased phosphorylation of MAPK1 protein] Epinephrine affects the activity of MAPK1 protein Epinephrine deficiency results in increased activity of MAPK1 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:11093795 PMID:15292328 PMID:17680988 PMID:22496244 |
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NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions affects activity increases activity increases phosphorylation |
ISO EXP |
ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; Epinephrine inhibits the reaction [Estradiol results in decreased phosphorylation of MAPK3 protein] Epinephrine affects the activity of MAPK3 protein Epinephrine deficiency results in increased activity of MAPK3 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:11093795 PMID:15292328 PMID:17680988 PMID:22496244 |
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NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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G |
Meis1 |
Meis homeobox 1 |
decreases expression |
ISO |
Epinephrine results in decreased expression of MEIS1 protein |
CTD |
PMID:31520687 |
|
NCBI chr14:97,356,949...97,499,646
Ensembl chr14:93,155,419...93,294,265
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G |
Myl2 |
myosin light chain 2 |
multiple interactions affects expression |
EXP |
[Epinephrine co-treated with Xanthine co-treated with XDH] affects the expression of MYL2 protein Epinephrine affects the expression of MYL2 protein |
CTD |
PMID:19464573 |
|
NCBI chr12:40,114,964...40,126,236
Ensembl chr12:34,454,218...34,468,983
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G |
Nefh |
neurofilament heavy chain |
affects expression |
EXP |
Epinephrine affects the expression of NEFH mRNA |
CTD |
PMID:22954530 |
|
NCBI chr14:84,044,428...84,054,413
Ensembl chr14:79,830,362...79,840,351
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
EXP |
Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of [RELA protein binds to NFKB1 protein]]; Epinephrine results in increased activity of [RELA protein binds to NFKB1 protein] |
CTD |
PMID:19135123 |
|
NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions increases expression |
ISO EXP |
Atenolol inhibits the reaction [Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Prazosin inhibits the reaction [Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] Epinephrine results in increased expression of NOS2 mRNA |
CTD |
PMID:16925470 PMID:19439816 |
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NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
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G |
Ntf3 |
neurotrophin 3 |
increases expression |
EXP |
Epinephrine results in increased expression of NTF3 mRNA; Epinephrine results in increased expression of NTF3 protein |
CTD |
PMID:19854260 |
|
NCBI chr 4:160,601,161...160,670,623
Ensembl chr 4:158,914,957...158,984,596
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G |
P2rx7 |
purinergic receptor P2X 7 |
decreases activity |
ISO |
Epinephrine results in decreased activity of P2RX7 protein |
CTD |
PMID:15459114 |
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NCBI chr12:39,550,531...39,594,984
Ensembl chr12:33,879,745...33,934,619
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G |
P2ry12 |
purinergic receptor P2Y12 |
multiple interactions |
ISO |
Epinephrine inhibits the reaction [P2RY12 gene mutant form results in decreased susceptibility to Adenosine Diphosphate] |
CTD |
PMID:11413167 |
|
NCBI chr 2:145,631,487...145,673,194
Ensembl chr 2:143,481,430...143,523,361
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
decreases cleavage |
ISO |
Epinephrine results in decreased cleavage of PARP1 protein |
CTD |
PMID:36423730 |
|
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
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G |
Pcna |
proliferating cell nuclear antigen |
increases expression |
ISO |
Epinephrine results in increased expression of PCNA protein |
CTD |
PMID:36423730 |
|
NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995
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G |
Phb1 |
prohibitin 1 |
multiple interactions increases expression |
EXP |
[Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of PHB1 protein Epinephrine results in increased expression of PHB1 protein |
CTD |
PMID:19464573 |
|
NCBI chr10:81,102,043...81,114,815
Ensembl chr10:80,605,251...80,618,042
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G |
Phgdh |
phosphoglycerate dehydrogenase |
increases expression |
EXP |
Epinephrine results in increased expression of PHGDH mRNA |
CTD |
PMID:12423672 |
|
NCBI chr 2:188,595,700...188,624,789
Ensembl chr 2:185,906,966...185,935,944
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G |
Pkm |
pyruvate kinase M1/2 |
multiple interactions increases expression |
EXP ISO |
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PKM protein Epinephrine results in increased expression of PKM protein |
CTD |
PMID:19464573 PMID:36423730 |
|
NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:60,057,402...60,079,599
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
increases expression |
EXP |
Epinephrine results in increased expression of PPARGC1A mRNA |
CTD |
PMID:22496244 |
|
NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656
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G |
Ppp2r1a |
protein phosphatase 2 scaffold subunit A alpha |
decreases expression multiple interactions |
EXP |
Epinephrine results in decreased expression of PPP2R1A protein [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PPP2R1A protein |
CTD |
PMID:19464573 |
|
NCBI chr 1:69,213,198...69,232,441
Ensembl chr 1:60,540,194...60,560,129
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G |
Prdx6 |
peroxiredoxin 6 |
multiple interactions decreases expression |
EXP |
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PRDX6 protein Epinephrine results in decreased expression of PRDX6 protein |
CTD |
PMID:19464573 |
|
NCBI chr13:76,062,082...76,072,631
Ensembl chr13:73,528,210...73,539,355
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G |
Prkce |
protein kinase C, epsilon |
affects response to substance |
ISO EXP |
PRKCE protein affects the susceptibility to Epinephrine |
CTD |
PMID:11454025 |
|
NCBI chr 6:13,718,050...14,204,931
Ensembl chr 6:7,965,048...8,451,719
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
decreases expression |
ISO |
Epinephrine results in decreased expression of PTGS2 mRNA; Epinephrine results in decreased expression of PTGS2 protein |
CTD |
PMID:31520687 |
|
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of [RELA protein binds to NFKB1 protein]]; Epinephrine results in increased activity of [RELA protein binds to NFKB1 protein] |
CTD |
PMID:19135123 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
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G |
Ren |
renin |
multiple interactions increases activity |
ISO |
ICI 118551 inhibits the reaction [Epinephrine results in increased activity of REN protein] |
CTD |
PMID:6314140 PMID:8592096 |
|
NCBI chr13:47,348,312...47,359,539
Ensembl chr13:44,796,091...44,807,489
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G |
Sct |
secretin |
multiple interactions |
EXP |
Epinephrine inhibits the reaction [SCT protein results in increased abundance of Cyclic AMP] |
CTD |
PMID:6312992 |
|
NCBI chr 1:205,812,435...205,813,246
Ensembl chr 1:196,382,856...196,383,658
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G |
Serpine1 |
serpin family E member 1 |
increases expression |
ISO |
Epinephrine results in increased expression of SERPINE1 mRNA |
CTD |
PMID:15850565 |
|
NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657
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G |
Slc22a3 |
solute carrier family 22 member 3 |
multiple interactions increases uptake |
EXP ISO |
[Corticosterone results in decreased activity of SLC22A3 protein] inhibits the reaction [Epinephrine results in increased abundance of Epinephrine metabolite]; [Corticosterone results in decreased activity of SLC22A3 protein] which results in decreased abundance of Epinephrine SLC22A3 protein results in increased uptake of Epinephrine |
CTD |
PMID:19053318 PMID:20858707 |
|
NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:48,235,476...48,324,612
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G |
Slc29a4 |
solute carrier family 29 member 4 |
increases uptake |
ISO |
SLC29A4 protein results in increased uptake of Epinephrine |
CTD |
PMID:20858707 |
|
NCBI chr12:11,853,540...11,884,660
Ensembl chr12:11,853,540...11,874,834
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions increases expression increases activity affects binding |
ISO EXP |
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Epinephrine results in increased activity of SOD1 protein]; Atenolol inhibits the reaction [Epinephrine results in increased activity of SOD1 protein]; Vitamin E inhibits the reaction [Epinephrine results in increased activity of SOD1 protein] Epinephrine results in increased expression of SOD1 mRNA; Epinephrine results in increased expression of SOD1 protein [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of SOD1 protein Epinephrine binds to SOD1 protein mutant form |
CTD |
PMID:11163531 PMID:19464573 PMID:23612299 |
|
NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions increases activity increases expression |
ISO EXP |
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Epinephrine results in increased activity of SOD2 protein]; Atenolol inhibits the reaction [Epinephrine results in increased activity of SOD2 protein]; Vitamin E inhibits the reaction [Epinephrine results in increased activity of SOD2 protein] Epinephrine results in increased expression of SOD2 mRNA; Epinephrine results in increased expression of SOD2 protein [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of SOD2 protein |
CTD |
PMID:11163531 PMID:19464573 |
|
NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189
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|
G |
Suclg2 |
succinate-CoA ligase GDP-forming subunit beta |
increases expression |
EXP |
Epinephrine results in increased expression of SUCLG2 protein |
CTD |
PMID:19464573 |
|
NCBI chr 4:129,623,833...129,893,937
Ensembl chr 4:128,067,033...128,337,170
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G |
Th |
tyrosine hydroxylase |
increases chemical synthesis multiple interactions |
ISO EXP |
TH protein results in increased chemical synthesis of Epinephrine [Clonidine results in increased expression of TH protein] which results in increased abundance of Epinephrine |
CTD |
PMID:9822156 PMID:19067675 |
|
NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767
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|
G |
Thy1 |
Thy-1 cell surface antigen |
multiple interactions decreases expression |
ISO |
Propranolol inhibits the reaction [Epinephrine results in decreased expression of THY1] |
CTD |
PMID:7558147 |
|
NCBI chr 8:53,286,396...53,291,541
Ensembl chr 8:44,389,513...44,394,659
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G |
Tnf |
tumor necrosis factor |
multiple interactions decreases secretion decreases expression |
ISO EXP |
Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] Epinephrine results in decreased secretion of TNF protein Epinephrine results in decreased expression of TNF mRNA |
CTD |
PMID:10588509 PMID:12423672 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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|
G |
Tp53 |
tumor protein p53 |
decreases expression |
ISO |
Epinephrine results in decreased expression of TP53 protein |
CTD |
PMID:36423730 |
|
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
|
|
G |
Vdac1 |
voltage-dependent anion channel 1 |
increases expression multiple interactions |
EXP |
Epinephrine results in increased expression of VDAC1 protein [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of VDAC1 protein |
CTD |
PMID:19464573 |
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NCBI chr10:37,029,377...37,060,542
Ensembl chr10:36,532,244...36,559,640
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G |
Wnt4 |
Wnt family member 4 |
decreases expression |
ISO |
Epinephrine results in decreased expression of WNT4 mRNA; Epinephrine results in decreased expression of WNT4 protein |
CTD |
PMID:31520687 |
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NCBI chr 5:154,797,245...154,818,565
Ensembl chr 5:149,514,018...149,532,859
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G |
Xdh |
xanthine dehydrogenase |
multiple interactions |
EXP |
[Epinephrine co-treated with Xanthine co-treated with XDH] affects the expression of MYL2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of AK2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of DES protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of DLAT protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ECHS1 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ETFB protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of FABP3 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HADH protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSP90AB1 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSPA9 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSPB6 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of IDH2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PKM protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PPP2R1A protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PRDX6 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of SOD2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of C1QBP protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of CYCS protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of HSPA5 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of PHB1 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of SOD1 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of VDAC1 protein; Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] affects the localization of HSF1 protein]; Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of [RELA protein binds to NFKB1 protein]]; Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of CASP3 protein] |
CTD |
PMID:19135123 PMID:19464573 |
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NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268
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G |
Serpinf1 |
serpin family F member 1 |
multiple interactions |
ISO |
epinephrine promotes the reaction [lipopolysaccharide increases expression of Serpinf1 protein in plasma] |
RGD |
PMID:9091588 |
RGD:11541073 |
NCBI chr10:60,748,504...60,760,898
Ensembl chr10:60,249,708...60,262,646
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