2-acetamidofluorenes - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	2-acetamidofluorenes	go back to main search page
Accession:	CHEBI:19432	browse the term
Definition:	An ortho-fused polycyclic arene, or derivative thereof, that consists of 9H-fluorene bearing an acetamido substituent at position 2.

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Rat (430 ) Mouse (427 ) Human (418 ) Chinchilla (0 ) Bonobo (0 ) Dog (0 ) Squirrel (0 ) Pig (0 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (430)

2-acetamidofluorene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aladin WD repeat nucleoporin

increases expression

ISO

2-Acetylaminofluorene results in increased expression of AAAS mRNA

NCBI chr 7:135,342,901...135,362,545
Ensembl chr 7:135,342,901...135,362,545

G

ATP binding cassette subfamily B member 1A

decreases expression
increases expression
multiple interactions
increases activity

ISO
EXP

2-Acetylaminofluorene results in decreased expression of ABCB1 mRNA
2-Acetylaminofluorene results in increased expression of ABCB1 mRNA; 2-Acetylaminofluorene results in increased expression of ABCB1A mRNA
lipopolysaccharide, E coli O55-B5 inhibits the reaction [2-Acetylaminofluorene results in increased expression of ABCB1A mRNA]
2-Acetylaminofluorene results in increased expression of ABCB1 mRNA; 2-Acetylaminofluorene results in increased expression of ABCB1 protein
Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 mRNA]; Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 protein]
2-Acetylaminofluorene results in increased activity of ABCB1 protein
[2-Acetylaminofluorene results in increased activity of AKT1 protein] which results in increased expression of ABCB1 mRNA; [2-Acetylaminofluorene results in increased activity of RAC1 protein] which results in increased expression of ABCB1 mRNA; [RELA protein binds to NFKB1 protein] affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 mRNA]

PMID:11170838 PMID:11960367 PMID:12387747 PMID:17303067 PMID:17669244 More...

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP-binding cassette, sub-family B member 1B

increases expression
multiple interactions

EXP

2-Acetylaminofluorene results in increased expression of ABCB1B mRNA; 2-Acetylaminofluorene results in increased expression of ABCB1B protein
[2-Acetylaminofluorene results in increased abundance of Reactive Oxygen Species] which results in increased expression of ABCB1B mRNA; lipopolysaccharide, E coli O55-B5 inhibits the reaction [2-Acetylaminofluorene results in increased expression of ABCB1B mRNA]; RELA protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1B mRNA]

PMID:11020383 PMID:11170838 PMID:12801967 PMID:17070881 PMID:22084566

NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567

G

ATP binding cassette subfamily C member 1

increases expression

EXP

2-Acetylaminofluorene results in increased expression of ABCC1 mRNA

PMID:12801967 PMID:17669244

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

G

ATP binding cassette subfamily C member 10

increases expression

ISO

2-Acetylaminofluorene results in increased expression of ABCC10 mRNA

NCBI chr 9:22,154,811...22,174,743
Ensembl chr 9:22,154,804...22,174,743

G

ATP binding cassette subfamily C member 2

increases expression
multiple interactions

ISO

2-Acetylaminofluorene results in increased expression of ABCC2 mRNA
NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCC2 mRNA]
2-Acetylaminofluorene results in increased expression of ABCC2 mRNA; 2-Acetylaminofluorene results in increased expression of ABCC2 protein

PMID:10691972 PMID:16381673 PMID:16426233

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

ATP binding cassette subfamily C member 3

increases expression

ISO
EXP

2-Acetylaminofluorene results in increased expression of ABCC3 mRNA; 2-Acetylaminofluorene results in increased expression of ABCC3 protein

PMID:10691972 PMID:12801967

NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494

G

ATP binding cassette subfamily G member 2

increases expression
increases activity
multiple interactions

ISO
EXP

2-Acetylaminofluorene results in increased expression of ABCG2 mRNA
2-Acetylaminofluorene results in increased activity of ABCG2 protein
2-Acetylaminofluorene results in increased expression of ABCG2 mRNA; 2-Acetylaminofluorene results in increased expression of ABCG2 protein
NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCG2 mRNA]

PMID:12819005 PMID:16381673 PMID:17538966 PMID:17669244 PMID:27475308

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493

G

acetyl-CoA acyltransferase 2

multiple interactions

EXP

[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of ACAA2 mRNA

NCBI chr18:70,620,310...70,648,417
Ensembl chr18:70,620,110...70,648,420

G

aminocarboxymuconate semialdehyde decarboxylase

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of ACMSD mRNA

NCBI chr13:41,752,894...41,798,427
Ensembl chr13:41,752,875...41,798,427

G

acyl-CoA thioesterase 9

increases expression

EXP

2-Acetylaminofluorene results in increased expression of ACOT9 mRNA

NCBI chr X:43,922,943...43,973,311
Ensembl chr X:43,914,923...43,973,205

G

acyl-CoA synthetase long-chain family member 3

increases expression

EXP

2-Acetylaminofluorene results in increased expression of ACSL3 mRNA

NCBI chr 9:87,563,601...87,613,078
Ensembl chr 9:87,563,601...87,613,097

G

apoptosis enhancing nuclease

increases expression

ISO
EXP

2-Acetylaminofluorene results in increased expression of AEN mRNA

PMID:17070881 PMID:21607683 PMID:22584684

NCBI chr 1:142,224,499...142,233,902
Ensembl chr 1:142,224,493...142,233,898

G

alpha-fetoprotein

multiple interactions
increases expression

EXP

[2-Acetylaminofluorene co-treated with Carbon Tetrachloride] affects the expression of AFP protein; [2-Acetylaminofluorene co-treated with Choline deficiency] results in increased expression of AFP protein
2-Acetylaminofluorene results in increased expression of AFP mRNA; 2-Acetylaminofluorene results in increased expression of AFP protein

PMID:6187438 PMID:11350689 PMID:11813887 PMID:15133858 PMID:17538966

NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,857,584...17,875,649

G

aryl hydrocarbon receptor

increases expression

ISO

2-Acetylaminofluorene results in increased expression of AHR mRNA

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

adenylate kinase 1

increases expression

ISO

2-Acetylaminofluorene results in increased expression of AK1 mRNA

NCBI chr 3:36,310,113...36,320,760
Ensembl chr 3:36,310,197...36,320,757

G

aldo-keto reductase family 1 member B1

increases expression

ISO

2-Acetylaminofluorene results in increased expression of AKR1B1 mRNA

NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:63,899,222...63,913,315

G

aldo-keto reductase family 1 member B10

multiple interactions
increases expression

EXP
ISO

[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of AKR1B10 mRNA
2-Acetylaminofluorene results in increased expression of AKR1B10 mRNA

PMID:14656948 PMID:26198647

NCBI chr 4:64,005,632...64,027,860
Ensembl chr 4:64,007,420...64,020,847

G

aldo-keto reductase family 1, member C12

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of AKR1C12 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of AKR1C12 mRNA

PMID:14656948 PMID:16158176

NCBI chr17:70,955,288...70,971,412
Ensembl chr17:70,955,294...70,971,431

G

aldo-keto reductase family 7 member A3

increases expression

EXP

2-Acetylaminofluorene results in increased expression of AKR7A3 mRNA

NCBI chr 5:156,876,721...156,884,599
Ensembl chr 5:156,874,086...156,885,153

G

AKT serine/threonine kinase 1

multiple interactions

ISO

2-Acetylaminofluorene results in increased phosphorylation of and results in increased activity of AKT1 protein; [2-Acetylaminofluorene results in increased activity of AKT1 protein] which results in increased expression of ABCB1 mRNA
2-Acetylaminofluorene results in increased phosphorylation of and results in increased activity of AKT1 protein; Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased phosphorylation of and results in increased activity of AKT1 protein]

PMID:11960367 PMID:17303067

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

albumin

multiple interactions
increases expression

EXP

[2-Acetylaminofluorene co-treated with Choline deficiency] results in increased expression of ALB protein
2-Acetylaminofluorene results in increased expression of ALB protein

PMID:6187438 PMID:15133858

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

aldehyde dehydrogenase 1 family, member A1

increases expression

EXP

2-Acetylaminofluorene results in increased expression of ALDH1A1 mRNA; 2-Acetylaminofluorene results in increased expression of ALDH1A1 protein

PMID:17070881 PMID:22584684 PMID:33211169

NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500

G

aldehyde dehydrogenase 1 family, member A3

increases expression

EXP

2-Acetylaminofluorene results in increased expression of ALDH1A3 mRNA

NCBI chr 1:129,392,516...129,436,552
Ensembl chr 1:129,392,516...129,427,777

G

aldehyde dehydrogenase 3 family, member A1

multiple interactions

ISO

TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of ALDH3A1 mRNA]

NCBI chr10:46,392,464...46,402,151
Ensembl chr10:46,392,411...46,402,151

G

alkaline phosphatase, biomineralization associated

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased activity of ALPL protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of ALPL protein; Allyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of ALPL protein]; Sulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of ALPL protein]; Tocotrienols affects the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased activity of ALPL protein]

PMID:15548946 PMID:15554553

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167

G

anaphase promoting complex subunit 11

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of ANAPC11 mRNA

NCBI chr10:106,373,610...106,384,633
Ensembl chr10:106,373,634...106,384,633

G

annexin A3

increases expression
multiple interactions

ISO
EXP

2-Acetylaminofluorene results in increased expression of ANXA3 mRNA
[Carbon Tetrachloride co-treated with 2-Acetylaminofluorene] results in increased expression of ANXA3 mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of ANXA3 mRNA]

PMID:17317680 PMID:18071240

NCBI chr14:13,031,675...13,085,678
Ensembl chr14:13,023,762...13,085,849

G

annexin A8

increases expression

ISO

2-Acetylaminofluorene results in increased expression of ANXA8 mRNA

NCBI chr16:9,403,267...9,418,317
Ensembl chr16:9,403,353...9,418,310

G

aldehyde oxidase 1

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of AOX1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of AOX1 mRNA

PMID:14656948 PMID:16158176

NCBI chr 9:67,073,831...67,152,980
Ensembl chr 9:67,073,821...67,152,980

G

apolipoprotein A2

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of APOA2 mRNA

NCBI chr13:86,176,767...86,178,819
Ensembl chr13:86,174,741...86,179,410

G

apolipoprotein A4

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of APOA4 mRNA

NCBI chr 8:55,435,779...55,438,160
Ensembl chr 8:55,434,168...55,438,164

G

apolipoprotein C3

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of APOC3 mRNA

NCBI chr 8:55,428,172...55,430,352
Ensembl chr 8:55,428,024...55,458,679

G

apolipoprotein D

decreases expression

ISO

2-Acetylaminofluorene results in decreased expression of APOD mRNA

NCBI chr11:82,936,216...82,957,264
Ensembl chr11:82,936,038...82,957,263

G

aquaporin 5

increases expression

EXP

2-Acetylaminofluorene results in increased expression of AQP5 mRNA

NCBI chr 7:132,601,528...132,605,060
Ensembl chr 7:132,601,059...132,605,062

G

amphiregulin

increases expression
multiple interactions

ISO

2-Acetylaminofluorene results in increased expression of AREG mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of AREG mRNA]

NCBI chr14:17,256,384...17,265,641
Ensembl chr14:17,256,384...17,265,641

G

asialoglycoprotein receptor 1

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of ASGR1 mRNA

NCBI chr10:55,274,299...55,278,323
Ensembl chr10:55,274,706...55,278,322

G

ATPase H+ transporting V1 subunit D

increases expression

EXP

2-Acetylaminofluorene results in increased expression of ATP6V1D mRNA

NCBI chr 6:103,389,778...103,405,346
Ensembl chr 6:103,389,783...103,405,346

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

ISO
EXP

TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of BAX mRNA]
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BAX protein; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BAX protein]
2-Acetylaminofluorene results in increased expression of BAX mRNA

PMID:11915028 PMID:17070881 PMID:17317680 PMID:19167416 PMID:21607683 More...

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions
increases expression

EXP

[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2 protein; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2 protein]
2-Acetylaminofluorene results in increased expression of BCL2 mRNA

PMID:11915028 PMID:19167416 PMID:22213190

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

multiple interactions
increases expression

EXP
ISO

[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2L1 protein; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2L1 protein]
2-Acetylaminofluorene results in increased expression of BCL2L1 mRNA

PMID:11915028 PMID:21607683

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

baculoviral IAP repeat-containing 5

increases expression

EXP

2-Acetylaminofluorene results in increased expression of BIRC5 mRNA

PMID:19167416 PMID:22213190

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155

G

BRCA1, DNA repair associated

increases expression

EXP

2-Acetylaminofluorene results in increased expression of BRCA1 mRNA

NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,917,693...86,977,763

G

BTG anti-proliferation factor 2

increases expression

EXP
ISO

2-Acetylaminofluorene results in increased expression of BTG2 mRNA

PMID:17070881 PMID:21607683

NCBI chr13:48,083,931...48,087,690
Ensembl chr13:48,083,931...48,087,690

G

basic leucine zipper and W2 domains 1

increases expression

ISO

2-Acetylaminofluorene results in increased expression of BZW1 mRNA

NCBI chr 9:67,424,860...67,438,656
Ensembl chr 9:67,424,866...67,439,684

G

complement component 4 binding protein, alpha

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of C4BPA mRNA

NCBI chr13:44,627,959...44,663,552
Ensembl chr13:44,627,982...44,663,471

G

complement C6

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of C6 mRNA

NCBI chr 2:55,573,596...55,648,857
Ensembl chr 2:55,573,653...55,649,120

G

complement C7

increases expression

EXP

2-Acetylaminofluorene results in increased expression of C7 mRNA

NCBI chr 2:55,815,687...55,892,605
Ensembl chr 2:55,816,807...55,892,672

G

calcium voltage-gated channel auxiliary subunit alpha2delta 1

increases expression

EXP

2-Acetylaminofluorene results in increased expression of CACNA2D1 mRNA

NCBI chr 4:19,902,324...20,330,287
Ensembl chr 4:19,905,764...20,330,147

G

cell adhesion molecule 1

increases expression

EXP

2-Acetylaminofluorene results in increased expression of CADM1 protein

NCBI chr 8:56,744,374...57,075,264
Ensembl chr 8:56,744,372...57,080,192

G

carbonic anhydrase 2

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CAR2 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CAR2 mRNA

PMID:14656948 PMID:16158176

NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:88,462,872...88,478,064

G

caspase 3

multiple interactions
increases activity
increases expression

EXP

2-Acetylaminofluorene inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased cleavage of CASP3 protein]; Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP3 protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of CASP3 protein]

PMID:12907702 PMID:23665045 PMID:26364502

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 7

multiple interactions
increases activity

EXP

Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP7 protein]

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

caspase 9

increases activity
increases expression
multiple interactions

EXP

2-Acetylaminofluorene results in increased activity of CASP9 protein
2-Acetylaminofluorene results in increased expression of CASP9 protein
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP9 protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of CASP9 protein]

PMID:23665045 PMID:26364502

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions
decreases expression
decreases activity

EXP

[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of CAT protein; Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of CAT protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in decreased activity of CAT protein]

PMID:17761372 PMID:23665045 PMID:26364502

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

caveolae associated protein 3

multiple interactions

EXP

[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CAVIN3 mRNA

NCBI chr 1:169,238,384...169,239,973
Ensembl chr 1:169,238,384...169,239,981

G

Cbl proto-oncogene C

increases expression

EXP

2-Acetylaminofluorene results in increased expression of CBLC mRNA

NCBI chr 1:88,567,930...88,584,709
Ensembl chr 1:88,567,932...88,584,709

G

carbonyl reductase 1

increases expression

ISO

2-Acetylaminofluorene results in increased expression of CBR1 mRNA

NCBI chr11:46,346,405...46,348,815
Ensembl chr11:46,378,411...46,381,104
Ensembl chr11:46,378,411...46,381,104

G

cholecystokinin

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of CCK mRNA

NCBI chr 8:130,031,012...130,037,702
Ensembl chr 8:130,031,013...130,037,686

G

C-C motif chemokine ligand 2

affects expression

EXP

2-Acetylaminofluorene affects the expression of CCL2 mRNA; 2-Acetylaminofluorene affects the expression of CCL2 protein

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 7

increases expression

EXP

2-Acetylaminofluorene results in increased expression of CCL7 protein

NCBI chr10:67,514,095...67,515,945
Ensembl chr10:67,514,091...67,515,947

G

cellular communication network factor 2

increases expression
multiple interactions

EXP

2-Acetylaminofluorene results in increased expression of CCN2 mRNA; 2-Acetylaminofluorene results in increased expression of CCN2 protein
Iloprost inhibits the reaction [2-Acetylaminofluorene results in increased expression of CCN2 mRNA]

NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976

G

cyclin A2

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of CCNA2 protein

NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701

G

cyclin B1

decreases expression
increases expression

EXP

2-Acetylaminofluorene results in decreased expression of CCNB1 protein
2-Acetylaminofluorene results in increased expression of CCNB1 mRNA

PMID:15158336 PMID:22584684

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin B2

increases expression
multiple interactions

ISO
EXP

2-Acetylaminofluorene results in increased expression of CCNB2 mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of CCNB2 mRNA]

PMID:17317680 PMID:19167416 PMID:22584684

NCBI chr 8:79,968,459...79,981,717
Ensembl chr 8:79,968,465...79,981,682

G

cyclin D1

multiple interactions
increases expression

EXP

[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCND1 mRNA; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCND1 mRNA]
2-Acetylaminofluorene results in increased expression of CCND1 mRNA

PMID:14633663 PMID:22584684

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin E1

multiple interactions
decreases activity

EXP

2-Acetylaminofluorene inhibits the reaction [CDK2 protein binds to CCNE1 protein]; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCNE1 mRNA; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCNE1 mRNA]
2-Acetylaminofluorene results in decreased activity of CCNE1 protein

PMID:10708481 PMID:14633663

NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822

G

cyclin G1

decreases expression
increases expression

EXP
ISO

2-Acetylaminofluorene results in decreased expression of CCNG1 mRNA
2-Acetylaminofluorene results in increased expression of CCNG1 mRNA

PMID:17070881 PMID:17317680 PMID:19167416 PMID:21607683 PMID:22584684

NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,677,885...25,683,766

G

Cd276 molecule

increases expression

EXP

2-Acetylaminofluorene results in increased expression of CD276 mRNA

PMID:17070881 PMID:21784091

NCBI chr 8:67,833,587...67,863,918
Ensembl chr 8:67,829,048...67,864,505

G

CD44 molecule

increases expression

EXP
IEP

2-Acetylaminofluorene results in increased expression of CD44 mRNA; 2-Acetylaminofluorene results in increased expression of CD44 protein
2-Fluorenylacetamide increases CD44 mRNA in liver, and protein in liver and serum

CTD
RGD

PMID:17187413 PMID:22584684 PMID:33211169 PMID:31966914

NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:109,612,054...109,699,424

G

cell division cycle 37, HSP90 cochaperone

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CDC37 mRNA; [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CDC37 protein

NCBI chr 8:27,954,292...27,966,935
Ensembl chr 8:27,948,016...27,983,931

G

cell division cycle associated 3

increases expression

EXP

2-Acetylaminofluorene results in increased expression of CDCA3 mRNA

NCBI chr 4:159,321,203...159,325,072
Ensembl chr 4:159,321,014...159,325,068

G

cadherin 13

increases expression

EXP

2-Acetylaminofluorene results in increased expression of CDH13 mRNA

NCBI chr19:63,258,251...64,296,122
Ensembl chr19:63,258,122...64,296,119

G

cadherin 22

increases expression

EXP

2-Acetylaminofluorene results in increased expression of CDH22 mRNA

NCBI chr 3:174,264,869...174,389,940
Ensembl chr 3:174,264,869...174,390,142

G

cadherin 3

increases expression

EXP

2-Acetylaminofluorene results in increased expression of CDH3 mRNA

NCBI chr19:51,303,414...51,353,900
Ensembl chr19:51,300,083...51,354,257

G

cyclin-dependent kinase 1

increases expression

EXP

2-Acetylaminofluorene results in increased expression of CDK1 mRNA

PMID:19167416 PMID:22584684

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

cyclin dependent kinase 2

multiple interactions
decreases activity

EXP

2-Acetylaminofluorene inhibits the reaction [CDK2 protein binds to CCNE1 protein]; 2-Acetylaminofluorene results in decreased localization of and results in decreased phosphorylation of and results in decreased activity of CDK2 protein
2-Acetylaminofluorene results in decreased activity of CDK2 protein

PMID:10708481 PMID:15158336

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878

G

cyclin-dependent kinase 4

increases activity

EXP

2-Acetylaminofluorene results in increased activity of CDK4 protein

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

EXP
ISO

2-Acetylaminofluorene inhibits the reaction [Diethylnitrosamine results in decreased expression of CDKN1A protein]; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of and affects the localization of CDKN1A protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CDKN1A mRNA; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CDKN1A mRNA]; pioglitazone inhibits the reaction [2-Acetylaminofluorene inhibits the reaction [Diethylnitrosamine results in decreased expression of CDKN1A protein]]
2-Acetylaminofluorene results in increased expression of CDKN1A mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of CDKN1A mRNA]
2-Acetylaminofluorene results in increased expression of CDKN1A mRNA; 2-Acetylaminofluorene results in increased expression of CDKN1A protein

PMID:10708481 PMID:11003613 PMID:14633663 PMID:17070881 PMID:17317680 More...

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

multiple interactions

EXP

2-Acetylaminofluorene promotes the reaction [Diethylnitrosamine results in decreased expression of CDKN1B protein]; Pioglitazone inhibits the reaction [2-Acetylaminofluorene promotes the reaction [Diethylnitrosamine results in decreased expression of CDKN1B protein]]

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

cyclin-dependent kinase inhibitor 2A

multiple interactions
increases methylation
increases expression

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CDKN2A mRNA; [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CDKN2A protein
2-Acetylaminofluorene results in increased methylation of CDKN2A gene; 2-Acetylaminofluorene results in increased methylation of CDKN2A promoter
2-Acetylaminofluorene results in increased expression of CDKN2A mRNA

PMID:16317707 PMID:18204080 PMID:19167416 PMID:20188851 PMID:22213190

NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248

G

cyclin-dependent kinase inhibitor 2B

increases expression

ISO
EXP

2-Acetylaminofluorene results in increased expression of CDKN2B mRNA

PMID:17317680 PMID:22213190

NCBI chr 5:109,123,308...109,134,906
Ensembl chr 5:109,114,322...109,134,855

G

cyclin-dependent kinase inhibitor 2C

increases expression

EXP

2-Acetylaminofluorene results in increased expression of CDKN2C mRNA

NCBI chr 5:129,639,736...129,645,564
Ensembl chr 5:129,639,736...129,644,891

G

cyclin-dependent kinase inhibitor 3

increases expression

EXP

2-Acetylaminofluorene results in increased expression of CDKN3 mRNA

PMID:22213190 PMID:22584684

NCBI chr15:22,502,299...22,513,725
Ensembl chr15:22,502,382...22,513,722

G

CCAAT/enhancer binding protein alpha

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of CEBPA protein

PMID:20188851 PMID:21785164

NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309

G

CCAAT/enhancer binding protein beta

multiple interactions
decreases expression

EXP

2-Acetylaminofluorene inhibits the reaction [CEBPB protein binds to HAMP promoter]
2-Acetylaminofluorene results in decreased expression of CEBPB protein

NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072

G

carboxylesterase 2E

increases expression

ISO

2-Acetylaminofluorene results in increased expression of CES2E mRNA

NCBI chr19:163,899...179,274
Ensembl chr19:163,859...179,308

G

carboxylesterase 3a

increases expression

ISO

2-Acetylaminofluorene results in increased expression of CES3 mRNA

NCBI chr19:49,902,312...49,910,484

G

creatine kinase, mitochondrial 1

increases expression

ISO

2-Acetylaminofluorene results in increased expression of CKMT1 mRNA

NCBI chr 3:128,783,408...128,789,485
Ensembl chr 3:128,783,597...128,789,483

G

claudin 4

increases expression

EXP

2-Acetylaminofluorene results in increased expression of CLDN4 mRNA

NCBI chr12:27,388,160...27,389,958
Ensembl chr12:27,387,981...27,389,958

G

claudin 7

increases expression

EXP

2-Acetylaminofluorene results in increased expression of CLDN7 mRNA

NCBI chr10:55,188,670...55,190,871
Ensembl chr10:55,188,684...55,190,905

G

clusterin

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CLU mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CLU mRNA

PMID:14656948 PMID:16158176

NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860

G

cytidine monophosphate N-acetylneuraminic acid synthetase

increases expression

EXP

2-Acetylaminofluorene results in increased expression of CMAS protein

NCBI chr 4:177,449,801...177,468,117
Ensembl chr 4:177,449,732...177,476,291

G

collagen type XVII alpha 1 chain

multiple interactions

ISO

TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of COL17A1 mRNA]

NCBI chr 1:256,472,648...256,518,857
Ensembl chr 1:256,472,648...256,518,851

G

COMM domain containing 3

increases expression

ISO

2-Acetylaminofluorene results in increased expression of COMMD3 mRNA

NCBI chr17:86,235,863...86,239,610
Ensembl chr17:86,235,863...86,239,610

G

coenzyme Q6 monooxygenase

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of COQ6 mRNA

NCBI chr 6:109,738,934...109,750,315
Ensembl chr 6:109,738,951...109,750,310

G

carboxypeptidase Q

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of CPQ mRNA

NCBI chr 7:66,148,973...66,719,189
Ensembl chr 7:66,149,377...66,716,137

G

carbamoyl-phosphate synthase 1

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Carbon Tetrachloride] affects the expression of CPS1 protein

NCBI chr 9:76,063,863...76,186,739
Ensembl chr 9:76,000,754...76,186,734

G

CREB binding protein

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of CREBBP mRNA

NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,822,620...11,968,266

G

crystallin, alpha B

increases expression

EXP

2-Acetylaminofluorene results in increased expression of CRYAB mRNA

NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:59,989,814...59,995,528

G

crystallin, lambda 1

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CRYL1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CRYL1 mRNA

PMID:14656948 PMID:16158176

NCBI chr15:35,542,628...35,661,563
Ensembl chr15:35,542,628...35,661,563

G

cystatin A

affects expression

ISO

2-Acetylaminofluorene affects the expression of CSTA mRNA

NCBI chr11:78,125,813...78,136,818
Ensembl chr11:78,125,800...78,136,822

G

C-X3-C motif chemokine ligand 1

increases expression

EXP

2-Acetylaminofluorene results in increased expression of CX3CL1 mRNA

NCBI chr19:10,233,326...10,244,856
Ensembl chr19:10,233,329...10,242,999

G

C-X-C motif chemokine ligand 1

affects expression

EXP

2-Acetylaminofluorene affects the expression of CXCL1 protein

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811

G

C-X-C motif chemokine ligand 10

affects expression

EXP

2-Acetylaminofluorene affects the expression of CXCL10 protein

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261

G

C-X-C motif chemokine ligand 12

multiple interactions
increases expression

EXP

[2-Acetylaminofluorene co-treated with Carbon Tetrachloride] results in increased expression of CXCL12 protein
2-Acetylaminofluorene results in increased expression of CXCL12 mRNA; 2-Acetylaminofluorene results in increased expression of CXCL12 protein

PMID:12626097 PMID:15579440

NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:152,060,780...152,073,627

G

C-X-C motif chemokine ligand 2

affects expression

EXP

2-Acetylaminofluorene affects the expression of CXCL2 protein

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255

G

C-X-C motif chemokine receptor 4

increases expression
multiple interactions

EXP

2-Acetylaminofluorene results in increased expression of CXCR4 mRNA
[2-Acetylaminofluorene co-treated with Carbon Tetrachloride] results in increased expression of CXCR4 protein

PMID:12626097 PMID:15579440

NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases hydrolysis
increases expression
multiple interactions

ISO
EXP

CYP1A1 results in increased hydrolysis of 2-Acetylaminofluorene
2-Acetylaminofluorene results in increased expression of CYP1A1 mRNA
2-Acetylaminofluorene analog results in increased expression of CYP1A1 protein; 2-Acetylaminofluorene results in increased expression of CYP1A1 mRNA; 2-Acetylaminofluorene results in increased expression of CYP1A1 protein
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP1A1 mRNA]

PMID:2334931 PMID:10445401 PMID:11888708 PMID:15916741 PMID:20713471 More...

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

affects metabolic processing
increases activity
increases hydrolysis
multiple interactions
decreases expression
increases expression

ISO
EXP

CYP1A2 protein affects the metabolism of 2-Acetylaminofluorene
CYP1A2 protein results in increased activity of 2-Acetylaminofluorene
CYP1A2 results in increased hydrolysis of 2-Acetylaminofluorene
NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP1A2 mRNA]
2-Acetylaminofluorene analog results in decreased expression of CYP1A2 protein; 2-Acetylaminofluorene results in decreased expression of CYP1A2 protein
2-Acetylaminofluorene results in increased expression of CYP1A2 protein

PMID:2334931 PMID:2655891 PMID:15450435 PMID:15916741 PMID:16381673 More...

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases expression
multiple interactions

ISO

2-Acetylaminofluorene results in increased expression of CYP1B1 mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of CYP1B1 mRNA]

PMID:17317680 PMID:20713471

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 2, subfamily a, polypeptide 1

increases expression

ISO

2-Acetylaminofluorene results in increased expression of CYP2A22 mRNA

NCBI chr 1:91,359,278...91,372,554
Ensembl chr 1:91,359,272...91,389,730

G

cytochrome P450, family 2, subfamily b, polypeptide 1

decreases expression
increases expression

EXP

2-Acetylaminofluorene analog results in decreased expression of CYP2B1 protein; 2-Acetylaminofluorene results in decreased expression of CYP2B1 protein
2-Acetylaminofluorene results in increased expression of CYP2B1 protein

PMID:10445401 PMID:15916741

NCBI chr 1:90,646,098...90,669,762

G

cytochrome P450, family 2, subfamily b, polypeptide 2

decreases expression

EXP

2-Acetylaminofluorene analog results in decreased expression of CYP2B2 protein; 2-Acetylaminofluorene results in decreased expression of CYP2B2 protein

NCBI chr 1:90,722,243...90,736,272

G

cytochrome P450, family 2, subfamily c, polypeptide 13

increases expression

EXP

2-Acetylaminofluorene results in increased expression of CYP2C13 mRNA

NCBI chr 1:248,706,787...248,787,239
Ensembl chr 1:248,706,788...248,787,210

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions
increases expression

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of CYP2E1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CYP2E1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CYP2E1 protein; Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP2E1 protein]
2-Acetylaminofluorene analog results in increased expression of CYP2E1 protein; 2-Acetylaminofluorene results in increased expression of CYP2E1 protein

PMID:14656948 PMID:15916741 PMID:16158176 PMID:17393424 PMID:23665045

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression

EXP

2-Acetylaminofluorene results in increased expression of CYP3A2 protein

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

increases expression
multiple interactions

EXP

2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 mRNA; 2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 protein
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of CYP3A23-3A1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CYP3A23-3A1 mRNA; NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 mRNA]; Trabectedin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 mRNA]

PMID:12504080 PMID:14656948 PMID:16158176

NCBI chr12:14,369,950...14,398,803
Ensembl chr12:14,368,266...14,398,813

G

cytochrome P450, family 4, subfamily f, polypeptide 5

increases expression

EXP

2-Acetylaminofluorene results in increased expression of CYP4F5 mRNA

NCBI chr 7:12,194,567...12,209,495
Ensembl chr 7:12,195,022...12,209,965

G

cytochrome P450 family 7 subfamily A member 1

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of CYP7A1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CYP7A1 mRNA

PMID:14656948 PMID:16158176

NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202

G

death-associated protein

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of DAP mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of DAP mRNA

PMID:14656948 PMID:16158176

NCBI chr 2:83,910,113...83,962,673
Ensembl chr 2:83,910,060...83,962,673

G

dimethylarginine dimethylaminohydrolase 1

increases expression

EXP

2-Acetylaminofluorene results in increased expression of DDAH1 mRNA

NCBI chr 2:237,327,812...237,460,624
Ensembl chr 2:237,327,766...237,460,626

G

DNA-damage-inducible transcript 4-like

increases expression

ISO

2-Acetylaminofluorene results in increased expression of DDIT4L mRNA

NCBI chr 2:228,800,831...228,804,478
Ensembl chr 2:228,801,705...228,806,225

G

discoidin domain receptor tyrosine kinase 1

increases expression

EXP

2-Acetylaminofluorene results in increased expression of DDR1 mRNA

NCBI chr20:3,047,269...3,069,277
Ensembl chr20:3,050,375...3,069,276

G

desmin

increases expression

EXP

2-Acetylaminofluorene results in increased expression of DES mRNA

NCBI chr 9:84,299,626...84,307,344
Ensembl chr 9:84,298,447...84,307,347

G

dihydroorotate dehydrogenase

decreases activity

EXP

2-Acetylaminofluorene results in decreased activity of DHODH protein

NCBI chr19:54,460,636...54,483,049
Ensembl chr19:54,468,690...54,514,496

G

delta like non-canonical Notch ligand 1

increases expression

EXP

2-Acetylaminofluorene results in increased expression of DLK1 mRNA; 2-Acetylaminofluorene results in increased expression of DLK1 protein

PMID:15567716 PMID:17187413 PMID:17538966

NCBI chr 6:134,192,491...134,199,779
Ensembl chr 6:134,192,518...134,200,529

G

dentin matrix acidic phosphoprotein 1

increases expression

ISO

2-Acetylaminofluorene results in increased expression of DMP1 mRNA

NCBI chr14:5,833,111...5,867,154
Ensembl chr14:5,833,111...5,843,993

G

E2F transcription factor 1

decreases expression
increases expression

EXP

2-Acetylaminofluorene results in decreased expression of E2F1 protein
2-Acetylaminofluorene results in increased expression of E2F1 mRNA

PMID:15158336 PMID:19167416 PMID:22213190

NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:163,524,739...163,535,563

G

E2F transcription factor 3

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of E2F3 protein

PMID:15158336 PMID:19167416

NCBI chr17:34,810,355...34,887,725
Ensembl chr17:34,809,998...34,887,725

G

E2F transcription factor 4

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of E2F4 protein

NCBI chr19:50,084,335...50,091,731
Ensembl chr19:50,084,335...50,091,834

G

ectodysplasin A2 receptor

increases expression

ISO

2-Acetylaminofluorene results in increased expression of EDA2R mRNA

NCBI chr X:66,225,557...66,280,674
Ensembl chr X:66,236,111...66,280,663

G

epidermal growth factor

decreases localization
multiple interactions

EXP

2-Acetylaminofluorene results in decreased localization of EGF protein
2-Acetylaminofluorene affects the reaction [EGF protein results in increased phosphorylation of EGFR protein]

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297

G

epidermal growth factor receptor

multiple interactions
decreases expression

EXP

2-Acetylaminofluorene affects the reaction [EGF protein results in increased phosphorylation of EGFR protein]
2-Acetylaminofluorene results in decreased expression of EGFR mRNA

PMID:10900465 PMID:22213190

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

early growth response 1

increases expression

EXP

2-Acetylaminofluorene results in increased expression of EGR1 mRNA

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

EI24, autophagy associated transmembrane protein

multiple interactions

ISO

TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of EI24 mRNA]

NCBI chr 8:44,683,138...44,699,502
Ensembl chr 8:44,683,144...44,695,214

G

epithelial membrane protein 2

increases expression

ISO

2-Acetylaminofluorene results in increased expression of EMP2 mRNA

NCBI chr10:5,866,869...5,901,533
Ensembl chr10:5,866,922...5,901,532

G

ectodermal-neural cortex 1

increases expression

ISO

2-Acetylaminofluorene results in increased expression of ENC1 mRNA

NCBI chr 2:30,285,274...30,297,194
Ensembl chr 2:30,283,736...30,315,721

G

enolase 1

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of ENO1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of ENO1 mRNA

PMID:14656948 PMID:16158176

NCBI chr 5:166,002,867...166,014,252
Ensembl chr 3:77,946,261...77,986,003
Ensembl chr 5:77,946,261...77,986,003

G

epithelial cell adhesion molecule

increases expression

EXP

2-Acetylaminofluorene results in increased expression of EPCAM mRNA

PMID:17070881 PMID:17187413

NCBI chr 6:12,633,715...12,649,678
Ensembl chr 6:12,631,611...12,649,702

G

Eph receptor A1

increases expression

ISO

2-Acetylaminofluorene results in increased expression of EPHA1 mRNA

NCBI chr 4:72,213,022...72,227,543
Ensembl chr 4:72,213,037...72,227,474

G

epoxide hydrolase 1

increases expression

EXP
ISO

2-Acetylaminofluorene results in increased expression of EPHX1 mRNA

PMID:17070881 PMID:17317680 PMID:21607683

NCBI chr13:95,246,079...95,275,852
Ensembl chr13:95,246,080...95,321,981

G

erb-b2 receptor tyrosine kinase 2

increases expression

EXP

2-Acetylaminofluorene results in increased expression of ERBB2 protein

NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,907,460...83,931,481

G

estrogen receptor 1

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of ESR1 mRNA

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

exocyst complex component 4

increases expression

ISO

2-Acetylaminofluorene results in increased expression of EXOC4 mRNA

NCBI chr 4:62,774,896...63,551,541
Ensembl chr 4:62,774,935...63,552,943

G

family with sequence similarity 110, member A

increases expression

ISO

2-Acetylaminofluorene results in increased expression of FAM110A mRNA

NCBI chr 3:160,934,815...160,945,405
Ensembl chr 3:160,931,777...160,949,897

G

Fas cell surface death receptor

increases expression

EXP

2-Acetylaminofluorene results in increased expression of FAS mRNA

PMID:17070881 PMID:22584684

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

F-box and WD repeat domain containing 9

increases expression

ISO

2-Acetylaminofluorene results in increased expression of FBXW9 mRNA

NCBI chr19:39,995,408...40,002,312
Ensembl chr19:39,995,408...40,002,312

G

fragile histidine triad diadenosine triphosphatase

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of FHIT mRNA

NCBI chr15:16,365,401...17,872,901
Ensembl chr15:16,747,338...17,872,621

G

Fms related receptor tyrosine kinase 3

affects expression

EXP

2-Acetylaminofluorene affects the expression of FLT3 mRNA

NCBI chr12:12,660,035...12,735,584
Ensembl chr12:12,659,946...12,735,581

G

fibronectin 1

increases expression

EXP

2-Acetylaminofluorene results in increased expression of FN1 mRNA

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of FOS protein; Drugs, Chinese Herbal inhibits the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of FOS protein]

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

ferritin heavy chain 1

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of FTH1 protein

NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:216,051,998...216,055,214

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of G6PC1 protein; Allyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of G6PC1 protein]; Sulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of G6PC1 protein]

NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033

G

alpha glucosidase

increases expression

ISO

2-Acetylaminofluorene results in increased expression of GAA mRNA

NCBI chr10:105,028,106...105,045,365
Ensembl chr10:105,028,307...105,045,366

G

growth arrest-specific 2 like 3

decreases expression

ISO

2-Acetylaminofluorene results in decreased expression of GAS2L3 mRNA

NCBI chr 7:25,690,929...25,726,806
Ensembl chr 7:25,693,660...25,716,942

G

glucagon receptor

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GCGR mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GCGR mRNA

PMID:14656948 PMID:16158176

NCBI chr10:106,306,803...106,314,970
Ensembl chr10:106,306,559...106,314,969

G

glutamate-cysteine ligase, catalytic subunit

increases expression
multiple interactions

ISO
EXP

2-Acetylaminofluorene results in increased expression of GCLC mRNA
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GCLC mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GCLC mRNA

PMID:14656948 PMID:16158176 PMID:16426233

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutamate cysteine ligase, modifier subunit

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GCLM mRNA

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

growth differentiation factor 15

increases expression

ISO

2-Acetylaminofluorene results in increased expression of GDF15 mRNA

NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022

G

gamma-glutamyltransferase 1

increases expression
multiple interactions

EXP

2-Acetylaminofluorene results in increased expression of GGT1 mRNA
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GGT1 protein; Allyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GGT1 protein]; Sulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GGT1 protein]

PMID:15554553 PMID:17187413

NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,141...13,088,050

G

gap junction protein, alpha 1

increases expression

EXP

2-Acetylaminofluorene results in increased expression of GJA1 mRNA; 2-Acetylaminofluorene results in increased expression of GJA1 protein

PMID:15133858 PMID:17187413

NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689

G

gap junction protein, beta 1

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of GJB1 mRNA

NCBI chr X:70,541,845...70,549,776
Ensembl chr X:70,541,862...70,549,843

G

gap junction protein, beta 2

increases expression

EXP

2-Acetylaminofluorene results in increased expression of GJB2 mRNA

NCBI chr15:35,375,977...35,393,817
Ensembl chr15:35,375,692...35,393,877

G

glutaredoxin 3

increases expression

ISO

2-Acetylaminofluorene results in increased expression of GLRX3 mRNA

NCBI chr 1:201,671,410...201,701,722
Ensembl chr 1:201,671,481...201,701,717

G

glypican 3

increases expression

EXP

2-Acetylaminofluorene results in increased expression of GPC3 mRNA

NCBI chr X:136,789,770...137,157,598
Ensembl chr X:136,789,770...137,157,639

G

glutathione peroxidase 2

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GPX2 mRNA

PMID:14656948 PMID:16158176

NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:101,226,745...101,230,862

G

glutamate ionotropic receptor AMPA type subunit 3

increases expression

EXP
ISO

2-Acetylaminofluorene results in increased expression of GRIA3 mRNA

PMID:17070881 PMID:21607683

NCBI chr X:125,103,975...125,369,690
Ensembl chr X:125,103,782...125,369,679

G

glutamate ionotropic receptor NMDA type subunit associated protein 1

increases expression

ISO

2-Acetylaminofluorene results in increased expression of GRINA mRNA

NCBI chr 7:109,842,870...109,846,048
Ensembl chr 7:109,843,196...109,846,042

G

glutathione-disulfide reductase

multiple interactions
decreases activity
decreases expression

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GSR mRNA; Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of GSR protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in decreased activity of GSR protein]

PMID:16158176 PMID:23665045 PMID:26364502

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glutathione synthetase

increases expression

ISO

2-Acetylaminofluorene results in increased expression of GSS mRNA

NCBI chr 3:164,508,005...164,538,343
Ensembl chr 3:164,508,005...164,538,306

G

glutathione S-transferase alpha 2

multiple interactions
increases expression

EXP
ISO

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GSTA2 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTA2 mRNA
2-Acetylaminofluorene results in increased expression of GSTA1 mRNA

PMID:14656948 PMID:16158176 PMID:17317680

NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:88,064,616...88,077,092

G

glutathione S-transferase mu 1

increases expression

EXP

2-Acetylaminofluorene results in increased expression of GSTM1 mRNA

NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569

G

glutathione S-transferase pi 1

multiple interactions
increases expression

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GSTP1 protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GSTP1 protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 protein; Allyl Compounds inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GSTP1 protein]; herbal compound 861 inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 mRNA]; herbal compound 861 inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 protein]; Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 mRNA]; Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of GSTP1 protein]; Sulfides inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of GSTP1 protein]
2-Acetylaminofluorene results in increased expression of GSTP1 mRNA; 2-Acetylaminofluorene results in increased expression of GSTP1 protein

PMID:12497209 PMID:12781041 PMID:12907702 PMID:15554553 PMID:17393424 More...

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

G-2 and S-phase expressed 1

increases expression

ISO

2-Acetylaminofluorene results in increased expression of GTSE1 mRNA

NCBI chr 7:118,829,793...118,846,662
Ensembl chr 7:118,829,903...118,846,661

G

H2A.X variant histone

increases expression
increases phosphorylation

EXP
ISO

2-Acetylaminofluorene results in increased expression of H2AX protein
2-Acetylaminofluorene results in increased phosphorylation of H2AX protein

PMID:26338220 PMID:34510228

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of HADHA mRNA

NCBI chr 6:31,907,801...31,947,434
Ensembl chr 6:31,907,291...31,947,698

G

hepcidin antimicrobial peptide

multiple interactions
decreases expression

EXP

2-Acetylaminofluorene inhibits the reaction [CEBPB protein binds to HAMP promoter]
2-Acetylaminofluorene results in decreased expression of HAMP mRNA

NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:95,298,307...95,300,297

G

heme binding protein 2

multiple interactions

ISO

TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of HEBP2 mRNA]

NCBI chr 1:15,014,729...15,021,523
Ensembl chr 1:15,014,729...15,021,523

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions

EXP

[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of HMGCR mRNA; beta-ionone promotes the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of HMGCR mRNA]

NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533

G

heme oxygenase 1

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of HMOX1 mRNA

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

HRas proto-oncogene, GTPase

increases expression

EXP

2-Acetylaminofluorene results in increased expression of HRAS protein

NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:205,725,975...205,729,590

G

hydroxysteroid (17-beta) dehydrogenase 6

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of HSD17B6 mRNA

NCBI chr 7:831,407...850,950
Ensembl chr 7:831,421...850,873

G

islet cell autoantigen 1

increases expression

EXP

2-Acetylaminofluorene results in increased expression of ICA1 mRNA

NCBI chr 4:37,622,759...37,771,055
Ensembl chr 4:37,622,759...37,770,569

G

inhibitor of DNA binding 1

increases expression

ISO

2-Acetylaminofluorene results in increased expression of ID1 mRNA

NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:161,671,538...161,672,685

G

interferon, alpha 1

multiple interactions

EXP

IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CDKN1A mRNA]; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCND1 mRNA]; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of CCNE1 mRNA]

NCBI chr 5:108,143,240...108,143,809
Ensembl chr 5:108,143,240...108,143,809

G

interferon alpha 2

multiple interactions

EXP

IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BAX protein]; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2 protein]; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of BCL2L1 protein]; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of TP53 protein]; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TGFB1 protein]; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD2 protein]; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein]

PMID:11915028 PMID:15368444

NCBI chr 5:108,374,363...108,374,941
Ensembl chr 5:108,374,363...108,374,941

G

interferon gamma

multiple interactions

EXP

2-Acetylaminofluorene inhibits the reaction [[Diethylnitrosamine co-treated with Methylnitrosourea co-treated with Butylhydroxybutylnitrosamine co-treated with diisopropanolnitrosamine co-treated with 1,2-Dimethylhydrazine] results in decreased expression of IFNG protein]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

insulin-like growth factor 2

increases expression

EXP

2-Acetylaminofluorene results in increased expression of IGF2 mRNA

NCBI chr 1:207,243,873...207,261,263
Ensembl chr 1:207,243,873...207,260,667

G

insulin-like growth factor binding protein, acid labile subunit

decreases expression

ISO

2-Acetylaminofluorene results in decreased expression of IGFALS mRNA

NCBI chr10:14,397,076...14,408,439
Ensembl chr10:14,403,399...14,407,138

G

inhibitor of nuclear factor kappa B kinase subunit beta

increases activity

ISO

2-Acetylaminofluorene results in increased activity of IKBKB protein

NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911

G

interleukin 10

affects expression

EXP

2-Acetylaminofluorene affects the expression of IL10 protein

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 12B

increases expression

EXP

2-Acetylaminofluorene results in increased expression of IL12B protein

NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194

G

interleukin 1 beta

multiple interactions
increases expression
affects expression

ISO
EXP

2-Acetylaminofluorene inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
2-Acetylaminofluorene results in increased expression of IL1B protein
2-Acetylaminofluorene affects the expression of IL1B mRNA

PMID:14670622 PMID:25051504

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 2 receptor subunit alpha

increases expression

EXP

2-Acetylaminofluorene results in increased expression of IL2RA mRNA

NCBI chr17:71,759,802...71,808,475
Ensembl chr17:71,759,802...71,808,507

G

interleukin 33

increases expression

ISO

2-Acetylaminofluorene results in increased expression of IL33 mRNA

NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:237,115,572...237,150,901

G

interleukin 5

increases expression

EXP

2-Acetylaminofluorene results in increased expression of IL5 protein

NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003

G

interleukin 6

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of IL6 protein

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

integrin subunit beta 4

increases expression

ISO

2-Acetylaminofluorene results in increased expression of ITGB4 mRNA

NCBI chr10:101,705,592...101,741,933
Ensembl chr10:101,705,587...101,741,932

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of JUN protein; Drugs, Chinese Herbal inhibits the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of JUN protein]

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

lysine demethylase 6A

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of KDM6A mRNA

NCBI chr X:6,920,374...7,060,027
Ensembl chr X:6,920,343...7,059,960

G

kinesin family member 11

increases expression

EXP

2-Acetylaminofluorene results in increased expression of KIF11 mRNA

NCBI chr 1:244,494,916...244,589,250
Ensembl chr 1:244,494,875...244,589,250

G

KIT proto-oncogene receptor tyrosine kinase

increases expression

EXP

2-Acetylaminofluorene results in increased expression of KIT protein

NCBI chr14:32,901,615...32,978,895
Ensembl chr14:32,903,033...32,978,812

G

keratin 14

increases expression

EXP

2-Acetylaminofluorene results in increased expression of KRT14 protein

NCBI chr10:85,638,182...85,642,450

G

keratin 15

increases expression
multiple interactions

ISO

2-Acetylaminofluorene results in increased expression of KRT15 mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT15 mRNA]

NCBI chr10:85,567,197...85,571,014
Ensembl chr10:85,567,202...85,571,142

G

keratin 19

increases expression
multiple interactions

EXP

2-Acetylaminofluorene results in increased expression of KRT19 mRNA; 2-Acetylaminofluorene results in increased expression of KRT19 protein
[Carbon Tetrachloride co-treated with 2-Acetylaminofluorene] results in increased expression of KRT19 protein

PMID:15133858 PMID:17187413 PMID:17661067

NCBI chr10:85,576,235...85,580,952
Ensembl chr10:85,576,235...85,580,952

G

keratin 20

decreases expression

ISO

2-Acetylaminofluorene results in decreased expression of KRT20 mRNA

NCBI chr10:84,880,952...84,890,285
Ensembl chr10:84,880,952...84,890,285

G

keratin 23

multiple interactions
increases expression

ISO

TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT23 mRNA]

NCBI chr10:84,930,603...84,946,929
Ensembl chr10:84,930,603...84,946,929

G

keratin 4

increases expression
multiple interactions

ISO

2-Acetylaminofluorene results in increased expression of KRT4 mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT4 mRNA]

NCBI chr 7:134,924,753...134,931,050
Ensembl chr 7:134,924,753...134,930,713

G

keratin 8

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of KRT8 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of KRT8 mRNA

PMID:14656948 PMID:16158176

NCBI chr 7:135,002,886...135,010,339
Ensembl chr 7:135,002,894...135,010,403

G

leptin

increases expression

EXP

2-Acetylaminofluorene results in increased expression of LEP protein

NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661

G

DNA ligase 4

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of LIG4 mRNA

NCBI chr16:86,220,345...86,228,930
Ensembl chr16:86,220,279...86,229,926

G

lymphocyte antigen 6 family member D

increases expression

ISO

2-Acetylaminofluorene results in increased expression of LY6D mRNA

NCBI chr 7:108,532,207...108,533,943
Ensembl chr 7:108,532,215...108,533,716

G

lymphocyte antigen 6 family member E

increases expression

ISO

2-Acetylaminofluorene results in increased expression of LY6E mRNA

NCBI chr 7:108,815,970...108,820,444
Ensembl chr 7:108,816,887...108,820,443

G

Ly6/Plaur domain containing 3

multiple interactions

ISO

TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of LYPD3 mRNA]

NCBI chr 1:89,354,354...89,358,806
Ensembl chr 1:89,354,335...89,358,810

G

leucine zipper and CTNNBIP1 domain containing

increases expression

ISO

2-Acetylaminofluorene results in increased expression of LZIC mRNA

NCBI chr 5:165,211,359...165,224,569
Ensembl chr 5:165,211,302...165,224,568

G

mal, T-cell differentiation protein

increases expression

ISO

2-Acetylaminofluorene results in increased expression of MAL mRNA

NCBI chr 3:135,317,664...135,341,423
Ensembl chr 3:135,317,664...135,341,423

G

mitogen-activated protein kinase 8

multiple interactions

EXP

2-Acetylaminofluorene affects the phosphorylation of and affects the activity of MAPK8 protein

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

methionine adenosyltransferase 1A

affects acetylation
affects methylation
decreases expression

EXP

2-Acetylaminofluorene affects the acetylation of MAT1A exon; 2-Acetylaminofluorene affects the acetylation of MAT1A promoter
2-Acetylaminofluorene affects the methylation of MAT1A exon; 2-Acetylaminofluorene affects the methylation of MAT1A promoter
2-Acetylaminofluorene results in decreased expression of MAT1A mRNA

NCBI chr16:17,017,168...17,035,368
Ensembl chr16:17,016,030...17,035,367

G

matrilin 2

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MATN2 mRNA; 2-Acetylaminofluorene results in increased expression of MATN2 protein

NCBI chr 7:67,380,140...67,529,767
Ensembl chr 7:67,380,168...67,530,153

G

mannose binding lectin 2

increases expression

ISO

2-Acetylaminofluorene results in increased expression of MBL2 mRNA

NCBI chr 1:237,429,873...237,465,567
Ensembl chr 1:237,429,973...237,437,546

G

MDM2 proto-oncogene

multiple interactions
increases expression

EXP
ISO

[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of and affects the localization of MDM2 protein
2-Acetylaminofluorene results in increased expression of MDM2 mRNA; 2-Acetylaminofluorene results in increased expression of MDM2 protein

PMID:11003613 PMID:19167416 PMID:21607683 PMID:22213190 PMID:22584684

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791

G

maternally expressed 3

decreases expression
multiple interactions

ISO

2-Acetylaminofluorene results in decreased expression of MEG3 mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of MEG3 mRNA]

NCBI chr 6:134,274,056...134,306,249

G

O-6-methylguanine-DNA methyltransferase

increases expression
decreases expression

EXP

2-Acetylaminofluorene results in increased expression of MGMT mRNA
2-Acetylaminofluorene results in decreased expression of MGMT mRNA

PMID:17070881 PMID:22213190

NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:201,140,661...201,367,482

G

microsomal glutathione S-transferase 2

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of MGST2 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MGST2 mRNA

PMID:14656948 PMID:16158176

NCBI chr 2:137,821,787...137,866,664
Ensembl chr 2:137,836,140...137,866,661

G

microRNA 106b

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MIR106B mRNA

NCBI chr12:22,157,053...22,157,134

G

microRNA 125b-1

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of MIR125B-1 mRNA

NCBI chr 8:50,850,036...50,850,122
Ensembl chr 8:50,850,036...50,850,122

G

microRNA 130b

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MIR130B mRNA

NCBI chr11:97,384,380...97,384,461
Ensembl chr11:97,384,380...97,384,461

G

microRNA 132

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MIR132 mRNA

NCBI chr10:60,522,033...60,522,133
Ensembl chr10:60,522,033...60,522,133

G

microRNA 146b

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MIR146B mRNA

NCBI chr 1:255,144,860...255,144,947
Ensembl chr 1:255,144,860...255,144,947

G

microRNA 155

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MIR155 mRNA

NCBI chr11:37,261,114...37,261,178
Ensembl chr11:37,261,114...37,261,178

G

microRNA 17

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MIR17; 2-Acetylaminofluorene results in increased expression of MIR17 mRNA

PMID:19167416 PMID:20188851

NCBI chr15:98,587,848...98,587,931
Ensembl chr15:98,587,848...98,587,931

G

microRNA 181a-1

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MIR181A-1 mRNA

NCBI chr13:52,037,067...52,037,166

G

microRNA 181b-2

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MIR181B-2 mRNA

NCBI chr 3:43,026,666...43,026,753
Ensembl chr 3:43,026,666...43,026,753

G

microRNA 181c

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of MIR181C mRNA

NCBI chr19:40,888,291...40,888,396
Ensembl chr19:40,888,291...40,888,396

G

microRNA 182

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MIR182 mRNA

NCBI chr 4:59,752,246...59,752,307

G

microRNA 185

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MIR185 mRNA

NCBI chr11:96,169,028...96,169,107
Ensembl chr11:96,169,028...96,169,107

G

microRNA 18a

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MIR18A; 2-Acetylaminofluorene results in increased expression of MIR18A mRNA

PMID:19167416 PMID:20188851

NCBI chr15:98,587,984...98,588,079
Ensembl chr15:98,587,984...98,588,079

G

microRNA 200a

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MIR200A mRNA

PMID:19167416 PMID:22584684

NCBI chr 5:171,930,717...171,930,805

G

microRNA 200b

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MIR200B mRNA

PMID:19167416 PMID:22584684

NCBI chr 5:171,931,495...171,931,589

G

microRNA 200c

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MIR200C mRNA

NCBI chr 4:159,209,965...159,210,033

G

microRNA 202

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of MIR202 mRNA

NCBI chr 1:204,184,345...204,184,416

G

microRNA 203

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of MIR203 mRNA

NCBI chr 6:137,020,691...137,020,805

G

microRNA 204

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of MIR204 mRNA

NCBI chr 1:229,743,461...229,743,570
Ensembl chr 1:229,743,461...229,743,570

G

microRNA 205

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MIR205 mRNA

NCBI chr13:107,564,535...107,564,642

G

microRNA 20a

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MIR20A; 2-Acetylaminofluorene results in increased expression of MIR20A mRNA

PMID:19167416 PMID:20188851

NCBI chr15:98,588,303...98,588,387
Ensembl chr15:98,588,303...98,588,387

G

microRNA 21

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MIR21 mRNA

NCBI chr10:71,902,600...71,902,691

G

microRNA 214

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MIR214 mRNA

NCBI chr13:77,121,645...77,121,752
Ensembl chr13:77,121,643...77,121,752

G

microRNA 22

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MIR22 mRNA

NCBI chr10:60,805,331...60,805,425
Ensembl chr10:60,805,331...60,805,425

G

microRNA 221

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MIR221 mRNA

NCBI chr X:6,023,182...6,023,290
Ensembl chr X:6,023,182...6,023,290

G

microRNA 293

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MIR293 mRNA

NCBI chr 1:74,878,457...74,878,528

G

microRNA 31

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MIR31; 2-Acetylaminofluorene results in increased expression of MIR31 mRNA

PMID:19167416 PMID:20188851

NCBI chr 5:108,714,849...108,714,954

G

microRNA 34a

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MIR34A mRNA

PMID:19167416 PMID:22584684

NCBI chr 5:165,815,952...165,816,053
Ensembl chr 5:165,815,952...165,816,053

G

microRNA 382

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MIR382 mRNA

NCBI chr 6:134,569,944...134,570,023

G

microRNA 410

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of MIR410 mRNA

NCBI chr 6:134,579,763...134,579,838
Ensembl chr 6:134,579,759...134,579,839

G

microRNA 429

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MIR429 mRNA

PMID:19167416 PMID:22584684

NCBI chr 5:171,929,682...171,929,766

G

microRNA 490

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of MIR490 mRNA

NCBI chr 4:66,014,586...66,014,669
Ensembl chr 4:66,014,586...66,014,669

G

microRNA 93

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MIR93; 2-Acetylaminofluorene results in increased expression of MIR93 mRNA

PMID:19167416 PMID:20188851

NCBI chr12:22,156,844...22,156,930

G

microRNA 96

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MIR96 mRNA

NCBI chr 4:59,755,841...59,755,946

G

microRNA 99a

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of MIR99A mRNA

PMID:19167416 PMID:22584684

NCBI chr11:29,687,392...29,687,472
Ensembl chr11:29,687,392...29,687,472

G

microRNA let-7b

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MIRLET7B mRNA

NCBI chr 7:118,684,038...118,684,122
Ensembl chr 7:118,684,038...118,684,122

G

microRNA let-7c

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MIRLET7C-1 mRNA

NCBI chr11:29,688,112...29,688,205
Ensembl chr11:29,688,107...29,688,214

G

microRNA let-7i

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MIRLET7I mRNA

NCBI chr 7:60,527,877...60,527,961

G

marker of proliferation Ki-67

multiple interactions
increases expression

EXP
ISO

[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MKI67 protein; Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of MKI67 protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MKI67 protein]; Vanadium inhibits the reaction [2-Acetylaminofluorene results in increased expression of MKI67 protein]
2-Acetylaminofluorene results in increased expression of MKI67 mRNA

PMID:15565650 PMID:17317680 PMID:17393424 PMID:23665045 PMID:26338220

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593

G

matrix metallopeptidase 2

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MMP2 mRNA

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 9

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MMP9 mRNA

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

metallothionein 1A

multiple interactions
increases expression

EXP

Vanadium inhibits the reaction [2-Acetylaminofluorene results in increased expression of MT1A protein]

NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200

G

methylenetetrahydrofolate reductase

decreases expression
decreases methylation

EXP

2-Acetylaminofluorene results in decreased expression of MTHFR mRNA
2-Acetylaminofluorene results in decreased methylation of MTHFR promoter

NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:163,748,321...163,768,105

G

mucin 1, cell surface associated

increases expression

EXP

2-Acetylaminofluorene results in increased expression of MUC1 mRNA

NCBI chr 2:176,933,312...176,938,497
Ensembl chr 2:176,933,047...176,938,491

G

MYB proto-oncogene like 1

increases expression

ISO

2-Acetylaminofluorene results in increased expression of MYBL1 mRNA

NCBI chr 5:14,365,768...14,401,012
Ensembl chr 5:14,365,768...14,399,588

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions
increases expression
increases mutagenesis

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of MYC protein; Drugs, Chinese Herbal inhibits the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of MYC protein]
2-Acetylaminofluorene results in increased expression of MYC protein
2-Acetylaminofluorene results in increased mutagenesis of MYC gene

PMID:11350689 PMID:17696247 PMID:19167416 PMID:20188851

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

nicotinamide phosphoribosyltransferase

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of NAMPT mRNA

NCBI chr 6:55,152,756...55,189,547
Ensembl chr 6:55,151,926...55,189,544

G

N-acetyltransferase 1

increases activity

ISO

NAT1 protein results in increased activity of 2-Acetylaminofluorene

NCBI chr16:26,984,882...27,005,194
Ensembl chr16:26,982,625...26,986,527

G

N-acetyltransferase 2

increases activity

ISO

NAT2 protein results in increased activity of 2-Acetylaminofluorene

NCBI chr16:26,974,874...27,005,191
Ensembl chr16:26,974,601...26,976,304

G

NIMA-related kinase 6

increases expression

EXP

2-Acetylaminofluorene results in increased expression of NEK6 mRNA

NCBI chr 3:42,693,994...42,766,026
Ensembl chr 3:42,693,971...42,767,773

G

NFE2 like bZIP transcription factor 2

increases expression
increases activity

ISO

2-Acetylaminofluorene results in increased expression of NFE2L2 mRNA
2-Acetylaminofluorene results in increased activity of NFE2L2 protein

PMID:21607683 PMID:30114225

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor kappa B subunit 1

multiple interactions
increases localization

ISO

[RELA protein binds to NFKB1 protein] affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 mRNA]
2-Acetylaminofluorene results in increased localization of NFKB1 protein
Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased localization of NFKB1 protein]

PMID:11960367 PMID:17303067

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

NFKB inhibitor alpha

multiple interactions

EXP

[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased phosphorylation of NFKBIA protein; Acetylcysteine inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased phosphorylation of NFKBIA protein]; S-Adenosylmethionine inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased phosphorylation of NFKBIA protein]

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

NFKB inhibitor beta

multiple interactions
increases degradation

EXP

[2-Acetylaminofluorene results in increased abundance of Reactive Oxygen Species] which results in increased degradation of NFKBIB protein
2-Acetylaminofluorene results in increased degradation of NFKBIB protein

NCBI chr 1:93,173,817...93,181,387
Ensembl chr 1:93,173,820...93,326,366

G

nerve growth factor receptor

increases expression

ISO

2-Acetylaminofluorene results in increased expression of TNFRSF10B mRNA

NCBI chr10:81,012,077...81,030,305
Ensembl chr10:81,012,089...81,030,305

G

ninjurin 1

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of NINJ1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NINJ1 mRNA

PMID:14656948 PMID:16158176

NCBI chr17:15,659,208...15,668,115
Ensembl chr17:15,659,200...15,668,063

G

nitric oxide synthase 2

multiple interactions
increases expression

EXP

[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NOS2 protein; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NOS2 protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of NOS2 protein]

PMID:23665045 PMID:26364502

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nitric oxide synthase 3

increases expression
multiple interactions

ISO

2-Acetylaminofluorene results in increased expression of NOS3 mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of NOS3 mRNA]

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

notch receptor 1

increases expression

ISO

2-Acetylaminofluorene results in increased expression of NOTCH1 mRNA

NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:29,676,171...29,721,613

G

NPR2-like, GATOR1 complex subunit

increases expression

ISO

2-Acetylaminofluorene results in increased expression of NPRL2 mRNA

NCBI chr 8:117,094,443...117,097,639
Ensembl chr 8:117,094,441...117,097,637

G

NAD(P)H quinone dehydrogenase 1

increases expression

ISO
EXP

2-Acetylaminofluorene results in increased expression of NQO1 mRNA

PMID:21607683 PMID:22213190

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear receptor subfamily 1, group I, member 2

increases expression
multiple interactions

ISO
EXP

2-Acetylaminofluorene results in increased expression of NR1I2 mRNA
NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 mRNA]
NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCC2 mRNA]; NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCG2 mRNA]; NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP1A2 mRNA]; NR1I2 protein affects the reaction [2-Acetylaminofluorene results in increased expression of CYP3A11 mRNA]

PMID:12504080 PMID:16381673

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

NudC domain containing 2

increases expression

ISO

2-Acetylaminofluorene results in increased expression of NUDCD2 mRNA

NCBI chr10:25,665,493...25,671,010
Ensembl chr10:25,665,509...25,682,902

G

nudix hydrolase 7

decreases expression

ISO

2-Acetylaminofluorene results in decreased expression of NUDT7 mRNA

NCBI chr19:59,034,808...59,049,148
Ensembl chr19:59,034,839...59,063,994

G

nucleoporin 50, pseudogene 1

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of SPG7 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of SPG7 mRNA

PMID:14656948 PMID:16158176

NCBI chr 4:130,344,273...130,346,002
Ensembl chr 4:130,342,422...130,346,296

G

nuclear protein 1, transcriptional regulator

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of NUPR1 mRNA

PMID:17070881 PMID:22584684

NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:190,643,867...190,645,901

G

nucleolar and spindle associated protein 1

increases expression

EXP

2-Acetylaminofluorene results in increased expression of NUSAP1 mRNA

NCBI chr 3:127,057,220...127,092,779
Ensembl chr 3:127,057,265...127,087,237

G

OCIA domain containing 2

increases expression

ISO

2-Acetylaminofluorene results in increased expression of OCIAD2 mRNA

NCBI chr14:35,225,291...35,243,306
Ensembl chr14:35,225,255...35,243,311

G

olfactomedin 1

increases expression

ISO

2-Acetylaminofluorene results in increased expression of OLFM1 mRNA

NCBI chr 3:31,918,512...31,956,261
Ensembl chr 3:31,918,573...31,956,260

G

olfactory receptor family 2 subfamily AT member 1

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of OR2AT1 mRNA

NCBI chr 1:163,501,335...163,502,300
Ensembl chr 1:163,501,335...163,502,300

G

oncostatin M

increases expression

EXP

2-Acetylaminofluorene results in increased expression of OSM mRNA

PMID:15743783 PMID:18678246

NCBI chr14:83,327,202...83,332,073
Ensembl chr14:83,327,554...83,331,827

G

oncostatin M receptor

increases expression

EXP

2-Acetylaminofluorene results in increased expression of OSMR mRNA

NCBI chr 2:57,634,517...57,688,802
Ensembl chr 2:57,634,517...57,688,561

G

peptidyl arginine deiminase 2

multiple interactions

ISO

TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of PADI2 mRNA]

NCBI chr 5:158,492,087...158,534,662
Ensembl chr 5:158,492,066...158,534,662

G

probasin

increases expression

EXP

2-Acetylaminofluorene results in increased expression of PBSN mRNA

NCBI chr X:45,792,738...45,807,983
Ensembl chr X:45,792,738...45,807,983

G

phosphoenolpyruvate carboxykinase 1

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of PCK1 mRNA

NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561

G

proliferating cell nuclear antigen

multiple interactions
increases expression

EXP

[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PCNA protein; Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PCNA protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein]; Vanadium inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein]

PMID:16352317 PMID:17393424 PMID:19167416 PMID:23665045 PMID:26364502

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

protein disulfide isomerase family A, member 3

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of PDIA3 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PDIA3 mRNA

PMID:14656948 PMID:16158176

NCBI chr 3:128,841,781...128,865,733
Ensembl chr 3:128,841,917...128,867,327

G

platelet and endothelial cell adhesion molecule 1

increases expression

EXP

2-Acetylaminofluorene results in increased expression of PECAM1 mRNA

NCBI chr10:92,090,263...92,152,002
Ensembl chr10:92,090,235...92,151,839

G

p53 apoptosis effector related to PMP22

multiple interactions

ISO

TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of PERP mRNA]

NCBI chr 1:15,361,784...15,374,230
Ensembl chr 1:15,361,778...15,374,687

G

pleckstrin homology-like domain, family A, member 3

increases expression

ISO
EXP

2-Acetylaminofluorene results in increased expression of PHLDA3 mRNA

PMID:17070881 PMID:21607683 PMID:22584684

NCBI chr13:49,745,003...49,748,088
Ensembl chr13:49,742,591...49,749,621

G

phytanoyl-CoA 2-hydroxylase

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of PHYH mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of PHYH mRNA

PMID:14656948 PMID:16158176

NCBI chr17:78,238,747...78,255,645
Ensembl chr17:78,238,747...78,255,645

G

phosphatidylinositol glycan anchor biosynthesis, class A

increases mutagenesis

EXP

2-Acetylaminofluorene results in increased mutagenesis of PIGA

NCBI chr X:33,672,832...33,687,747
Ensembl chr X:33,674,923...33,687,636

G

polycystin 1, transient receptor potential channel interacting

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of PKD1 mRNA

NCBI chr10:14,077,733...14,125,682
Ensembl chr10:14,078,679...14,125,681

G

pyruvate kinase M1/2

increases expression

EXP

2-Acetylaminofluorene results in increased expression of PKM mRNA; 2-Acetylaminofluorene results in increased expression of PKM protein

NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:68,948,815...68,975,396

G

plakophilin 1

increases expression

ISO

2-Acetylaminofluorene results in increased expression of PKP1 mRNA

NCBI chr13:49,861,340...49,909,162
Ensembl chr13:49,861,340...49,909,162

G

polo-like kinase 2

increases expression

ISO

2-Acetylaminofluorene results in increased expression of PLK2 mRNA

NCBI chr 2:43,702,536...43,708,305
Ensembl chr 2:43,701,865...43,708,296

G

phorbol-12-myristate-13-acetate-induced protein 1

increases expression
multiple interactions

ISO
EXP

2-Acetylaminofluorene results in increased expression of PMAIP1 mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of PMAIP1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of PMAIP1 mRNA]

PMID:17317680 PMID:19167416

NCBI chr18:62,255,970...62,262,384
Ensembl chr18:62,255,598...62,262,382

G

DNA polymerase kappa

increases expression

ISO

2-Acetylaminofluorene results in increased expression of POLK mRNA

NCBI chr 2:29,556,831...29,616,960
Ensembl chr 2:29,557,336...29,616,960

G

cytochrome p450 oxidoreductase

increases expression

EXP

2-Acetylaminofluorene results in increased expression of POR mRNA

NCBI chr12:26,587,674...26,655,612
Ensembl chr12:26,587,674...26,635,809

G

protein regulator of cytokinesis 1

increases expression

EXP

2-Acetylaminofluorene results in increased expression of PRC1 mRNA

NCBI chr 1:143,659,312...143,681,019
Ensembl chr 1:143,659,481...143,681,012

G

protein kinase C, eta

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of PRKCH mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PRKCH mRNA

PMID:14656948 PMID:16158176

NCBI chr 6:98,027,830...98,226,486
Ensembl chr 6:98,027,646...98,226,477

G

prominin 1

increases expression

EXP

2-Acetylaminofluorene results in increased expression of PROM1 mRNA

NCBI chr14:71,202,303...71,307,008
Ensembl chr14:71,202,336...71,307,002

G

prospero homeobox 1

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of PROX1 mRNA

NCBI chr13:104,196,615...104,251,007
Ensembl chr13:104,200,378...104,250,975

G

proteasome 26S subunit, non-ATPase 10

increases expression
multiple interactions

EXP

2-Acetylaminofluorene results in increased expression of PSMD10 protein
RB1 protein affects the reaction [2-Acetylaminofluorene results in increased expression of PSMD10 protein]

NCBI chr X:109,445,291...109,453,605
Ensembl chr X:109,445,291...109,453,605

G

proline and serine rich coiled-coil 1

increases expression

ISO

2-Acetylaminofluorene results in increased expression of PSRC1 mRNA

NCBI chr 2:198,710,427...198,715,001
Ensembl chr 2:198,705,839...198,714,997

G

phosphatase and tensin homolog

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of PTEN protein

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330

G

prostaglandin reductase 1

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of PTGR1 mRNA

NCBI chr 5:78,579,060...78,597,671
Ensembl chr 5:78,579,057...78,597,811

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

EXP

[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PTGS2 protein; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PTGS2 protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of PTGS2 protein]

PMID:23665045 PMID:26364502

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

pleiotrophin

increases expression

EXP

2-Acetylaminofluorene results in increased expression of PTN mRNA

NCBI chr 4:66,260,764...66,342,614
Ensembl chr 4:66,260,764...66,342,482

G

protein tyrosine phosphatase 4A3

increases expression

ISO

2-Acetylaminofluorene results in increased expression of PTP4A3 mRNA

NCBI chr 7:107,518,220...107,549,949
Ensembl chr 7:107,541,047...107,549,949

G

protein tyrosine phosphatase, receptor type, C

increases expression

EXP

2-Acetylaminofluorene results in increased expression of PTPRC mRNA

NCBI chr13:52,147,717...52,259,810
Ensembl chr13:52,147,717...52,259,746

G

PTTG1 regulator of sister chromatid separation, securin

increases expression

EXP

2-Acetylaminofluorene results in increased expression of PTTG1 mRNA

NCBI chr10:28,394,940...28,406,410
Ensembl chr10:28,394,814...28,406,309

G

Pvt1 oncogene

increases expression

ISO

2-Acetylaminofluorene results in increased expression of PVT1 mRNA

NCBI chr 7:95,545,916...95,769,306

G

Rac family small GTPase 1

increases activity
multiple interactions

ISO

2-Acetylaminofluorene results in increased activity of RAC1 protein
[2-Acetylaminofluorene results in increased activity of RAC1 protein] which results in increased expression of ABCB1 mRNA

NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109

G

Ras association domain family member 1

increases methylation

EXP

2-Acetylaminofluorene results in increased methylation of RASSF1 promoter

NCBI chr 8:117,103,665...117,114,805
Ensembl chr 8:117,103,362...117,114,805

G

RB transcriptional corepressor 1

affects phosphorylation
multiple interactions

EXP

2-Acetylaminofluorene affects the phosphorylation of RB1 protein
2-Acetylaminofluorene results in increased expression of and results in increased phosphorylation of RB1 protein; RB1 protein affects the reaction [2-Acetylaminofluorene results in increased expression of PSMD10 protein]

PMID:15158336 PMID:16448463

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857

G

ring-box 1

increases expression

ISO

2-Acetylaminofluorene results in increased expression of RBX1 mRNA

NCBI chr 7:114,870,893...114,881,194
Ensembl chr 7:114,870,972...114,881,191

G

RELA proto-oncogene, NF-kB subunit

increases activity
increases expression
multiple interactions
increases localization

ISO
EXP

2-Acetylaminofluorene results in increased activity of RELA protein
2-Acetylaminofluorene results in increased expression of RELA protein
geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of RELA protein]; RELA protein affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1B mRNA]
2-Acetylaminofluorene results in increased localization of RELA protein
[RELA protein binds to NFKB1 protein] affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 mRNA]
2-Acetylaminofluorene inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased localization of RELA protein]

PMID:11020383 PMID:11960367 PMID:14670622 PMID:17303067 PMID:26364502

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

regucalcin

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of RGN mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of RGN mRNA

PMID:14656948 PMID:16158176

NCBI chr X:4,172,537...4,190,112
Ensembl chr X:4,172,537...4,190,251

G

regulator of G-protein signaling 2

increases expression

EXP

2-Acetylaminofluorene results in increased expression of RGS2 mRNA

NCBI chr13:58,350,063...58,352,666
Ensembl chr13:58,349,163...58,352,697

G

rhomboid 5 homolog 2

increases expression

ISO

2-Acetylaminofluorene results in increased expression of RHBDF2 mRNA

NCBI chr10:102,331,991...102,359,117
Ensembl chr10:102,331,991...102,359,117

G

ras homolog family member B

increases expression

EXP

2-Acetylaminofluorene results in increased expression of RHOB mRNA

NCBI chr 6:37,083,030...37,085,204
Ensembl chr 6:37,075,015...37,112,772

G

Rho-related BTB domain containing 2

increases expression

EXP

2-Acetylaminofluorene results in increased expression of RHOBTB2 mRNA

NCBI chr15:51,278,024...51,298,209
Ensembl chr15:51,280,149...51,298,209

G

receptor interacting serine/threonine kinase 1

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of RIPK1 mRNA

NCBI chr17:31,044,983...31,077,167
Ensembl chr17:31,044,994...31,077,167

G

receptor-interacting serine-threonine kinase 3

increases expression

ISO

2-Acetylaminofluorene results in increased expression of RIPK3 mRNA

NCBI chr15:33,253,071...33,262,025
Ensembl chr15:33,253,071...33,262,025

G

receptor-interacting serine-threonine kinase 4

increases expression

ISO

2-Acetylaminofluorene results in increased expression of RIPK4 mRNA

NCBI chr11:50,591,926...50,614,169
Ensembl chr11:50,591,936...50,614,169

G

ROS proto-oncogene 1 , receptor tyrosine kinase

increases expression

EXP

2-Acetylaminofluorene results in increased expression of ROS1 mRNA

NCBI chr20:31,975,328...32,126,675
Ensembl chr20:31,975,329...32,126,547

G

ribosomal protein lateral stalk subunit P0

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of RPLP0 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of RPLP0 mRNA

PMID:14656948 PMID:16158176

NCBI chr12:46,715,121...46,718,390
Ensembl chr12:46,715,124...46,718,422

G

reprimo, TP53 dependent G2 arrest mediator homolog

multiple interactions
increases expression
decreases expression

ISO
EXP

TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of RPRM mRNA]
2-Acetylaminofluorene results in increased expression of RPRM mRNA
2-Acetylaminofluorene results in decreased expression of RPRM mRNA

PMID:17317680 PMID:19167416 PMID:22584684

NCBI chr 3:58,948,618...58,950,035
Ensembl chr 3:58,799,866...58,950,542

G

ribosomal protein S27-like

increases expression

ISO

2-Acetylaminofluorene results in increased expression of RPS27L mRNA

NCBI chr 8:76,443,658...76,448,593
Ensembl chr12:33,713,661...33,714,130
Ensembl chr 8:33,713,661...33,714,130

G

ribonucleotide reductase catalytic subunit M1

increases expression

ISO

2-Acetylaminofluorene results in increased expression of RRM1 mRNA

NCBI chr 1:166,235,904...166,260,206
Ensembl chr 1:166,235,900...166,260,944

G

ribonucleotide reductase regulatory TP53 inducible subunit M2B

increases expression

ISO

2-Acetylaminofluorene results in increased expression of RRM2B mRNA

NCBI chr 7:70,962,008...70,993,726
Ensembl chr 7:70,965,590...70,993,670

G

radical S-adenosyl methionine domain containing 2

decreases expression

ISO

2-Acetylaminofluorene results in decreased expression of RSAD2 mRNA

NCBI chr 6:48,774,985...48,788,245
Ensembl chr 6:48,774,985...48,788,320

G

S100 calcium binding protein A11

increases expression

ISO

2-Acetylaminofluorene results in increased expression of S100A11 mRNA

NCBI chr 2:181,875,132...181,880,542
Ensembl chr 2:181,875,130...181,880,541

G

S100 calcium binding protein A14

increases expression

ISO

2-Acetylaminofluorene results in increased expression of S100A14 mRNA

NCBI chr 2:178,305,976...178,308,004
Ensembl chr 2:178,306,025...178,307,999

G

scavenger receptor class B, member 2

increases expression

ISO

2-Acetylaminofluorene results in increased expression of SCARB2 mRNA

NCBI chr14:15,842,583...15,894,123
Ensembl chr14:15,842,515...15,896,671

G

serine carboxypeptidase 1

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of SCPEP1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of SCPEP1 mRNA

PMID:14656948 PMID:16158176

NCBI chr10:74,200,491...74,230,107
Ensembl chr10:74,200,491...74,230,241

G

secretin receptor

increases expression

EXP

2-Acetylaminofluorene results in increased expression of SCTR mRNA

NCBI chr13:33,680,562...33,744,049
Ensembl chr13:33,680,627...33,733,709

G

serpin family A member 7

increases expression

EXP

2-Acetylaminofluorene results in increased expression of SERPINA7 mRNA

NCBI chr X:107,452,044...107,510,958
Ensembl chr X:107,452,044...107,457,681

G

serpin family B member 5

increases expression
multiple interactions

ISO

2-Acetylaminofluorene results in increased expression of SERPINB5 mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of SERPINB5 mRNA]

NCBI chr13:23,500,203...23,520,401
Ensembl chr13:23,500,198...23,520,400

G

serpin family F member 1

decreases expression

ISO

2-Acetylaminofluorene results in decreased expression of SERPINF1 mRNA

NCBI chr10:60,748,504...60,760,898
Ensembl chr10:60,748,506...60,760,898

G

sestrin 2

increases expression

ISO

2-Acetylaminofluorene results in increased expression of SESN2 mRNA

NCBI chr 5:149,986,304...150,005,255
Ensembl chr 5:149,986,317...150,005,255

G

stratifin

increases expression

EXP

2-Acetylaminofluorene results in increased expression of SFN mRNA

PMID:19167416 PMID:22213190

NCBI chr 5:151,110,582...151,111,854
Ensembl chr 5:151,110,530...151,111,995

G

sirtuin 1

increases expression

EXP

2-Acetylaminofluorene results in increased expression of SIRT1 protein

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000

G

solute carrier family 15, member 5

decreases expression

ISO

2-Acetylaminofluorene results in decreased expression of SLC15A5 mRNA

NCBI chr 4:172,609,293...172,702,893
Ensembl chr 4:172,608,999...172,702,893

G

solute carrier family 16 member 10

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of SLC16A10 mRNA

NCBI chr20:45,014,229...45,122,392
Ensembl chr20:45,014,235...45,122,358

G

solute carrier family 25 member 4

multiple interactions

ISO

TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of SLC25A4 mRNA]

NCBI chr16:52,805,521...52,809,316
Ensembl chr16:52,805,523...52,811,700

G

solute carrier family 2 member 8

multiple interactions

ISO

TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of SLC2A8 mRNA]

NCBI chr 3:36,672,589...36,682,206
Ensembl chr 3:36,672,591...36,682,194

G

solute carrier family 40 member 1

increases expression

EXP

2-Acetylaminofluorene results in increased expression of SLC40A1 mRNA

NCBI chr 9:55,525,457...55,633,463
Ensembl chr 9:55,525,532...55,543,460

G

solute carrier organic anion transporter family, member 1a4

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of SLCO1A4 mRNA

NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:176,441,104...176,495,816

G

solute carrier organic anion transporter family member 1B2

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of SLCO1B2 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of SLCO1B2 mRNA

PMID:14656948 PMID:16158176

NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083

G

SMAD family member 2

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD2 protein; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD2 protein]

NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388

G

SMAD family member 3

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein]

NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324

G

SMAD family member 4

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of SMAD4 mRNA

NCBI chr18:69,518,988...69,549,684
Ensembl chr18:69,518,988...69,549,684

G

smoothened, frizzled class receptor

increases expression

EXP

2-Acetylaminofluorene results in increased expression of SMO mRNA

NCBI chr 4:59,311,084...59,341,280
Ensembl chr 4:59,311,041...59,341,281

G

synuclein, gamma

increases expression

EXP

2-Acetylaminofluorene results in increased expression of SNCG mRNA

NCBI chr16:9,706,765...9,712,072
Ensembl chr16:9,706,753...9,712,076

G

syntrophin, gamma 2

decreases expression

ISO

2-Acetylaminofluorene results in decreased expression of SNTG2 mRNA

NCBI chr 6:52,529,481...52,730,972
Ensembl chr 6:52,529,481...52,730,972

G

suppressor of cytokine signaling 1

increases expression

EXP

2-Acetylaminofluorene results in increased expression of SOCS1 mRNA

NCBI chr10:5,389,574...5,391,265
Ensembl chr10:5,389,334...5,391,847

G

superoxide dismutase 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased activity of SOD1 protein

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

multiple interactions

EXP

[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of and results in increased activity of SOD2 protein; O-(Chloroacetylcarbamoyl)fumagillol inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of and results in increased activity of SOD2 protein]

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

SRY-box transcription factor 4

increases expression

EXP

2-Acetylaminofluorene results in increased expression of SOX4 mRNA

NCBI chr17:35,876,298...35,881,004
Ensembl chr17:35,875,756...35,884,024

G

serine peptidase inhibitor, Kazal type 1

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of SPINK1 mRNA

NCBI chr18:36,121,626...36,133,596
Ensembl chr18:36,076,399...36,133,545

G

small proline-rich protein 1A

increases expression

ISO

2-Acetylaminofluorene results in increased expression of SPRR1A mRNA

NCBI chr 2:180,750,709...180,752,625
Ensembl chr 2:180,750,709...180,752,991

G

small proline rich protein 2F

increases expression
multiple interactions

ISO

2-Acetylaminofluorene results in increased expression of SPRR2F mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of SPRR2F mRNA]

NCBI chr 2:180,685,587...180,685,817
Ensembl chr 2:180,685,587...180,685,817

G

serine palmitoyltransferase, long chain base subunit 2

increases expression

ISO

2-Acetylaminofluorene results in increased expression of SPTLC2 mRNA

NCBI chr 6:112,679,623...112,762,470
Ensembl chr 6:112,679,623...112,762,640

G

somatostatin

increases expression

EXP

2-Acetylaminofluorene results in increased expression of SST protein

NCBI chr11:90,461,546...90,462,823
Ensembl chr11:90,461,546...90,462,823

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 3

decreases expression

ISO

2-Acetylaminofluorene results in decreased expression of ST3GAL3 mRNA

NCBI chr 5:136,755,780...136,958,081
Ensembl chr 5:136,755,678...136,955,987

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 5

increases expression

EXP

2-Acetylaminofluorene results in increased expression of ST3GAL5 protein

NCBI chr 4:105,692,840...105,750,774
Ensembl chr 4:105,692,840...105,750,775

G

signal transducer and activator of transcription 3

multiple interactions

EXP

[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of STAT3 protein; Dexamethasone inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased activity of STAT3 protein]

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

STEAP3 metalloreductase

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of STEAP3 mRNA

NCBI chr13:33,904,710...33,950,100
Ensembl chr13:33,904,710...33,950,080

G

stathmin 1

increases expression

EXP

2-Acetylaminofluorene results in increased expression of STMN1 mRNA

NCBI chr 5:151,964,308...151,970,843
Ensembl chr 5:151,964,351...151,970,842

G

succinylCoA:glutarate-CoA transferase

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of SUGCT mRNA

NCBI chr17:52,072,012...52,929,852
Ensembl chr17:52,072,052...52,930,281

G

sulfatase 2

increases expression

EXP
ISO

2-Acetylaminofluorene results in increased expression of SULF2 mRNA

PMID:17070881 PMID:21607683

NCBI chr 3:175,241,322...175,323,808
Ensembl chr 3:175,241,322...175,323,651

G

sulfotransferase family 1C member 2A

decreases expression

ISO

2-Acetylaminofluorene results in decreased expression of SULT1C2 mRNA

NCBI chr 9:7,075,873...7,103,316
Ensembl chr 9:7,066,905...7,244,132

G

sulfotransferase family 1E member 1

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of SULT1E1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of SULT1E1 mRNA

PMID:14656948 PMID:16158176

NCBI chr14:20,700,444...20,718,719
Ensembl chr14:20,700,292...20,718,716

G

sulfotransferase family 2A member 1

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of SULT2A1 mRNA

NCBI chr 1:84,582,011...84,639,001

G

transaldolase 1

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TALDO1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TALDO1 mRNA

PMID:14656948 PMID:16158176

NCBI chr 1:205,923,196...205,933,526
Ensembl chr 1:205,923,165...205,933,535

G

transcription elongation factor A like 9

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TCEAL9 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TCEAL9 mRNA

PMID:14656948 PMID:16158176

NCBI chr X:104,037,274...104,039,345
Ensembl chr X:104,032,421...104,041,562

G

testin LIM domain protein

increases expression

EXP

2-Acetylaminofluorene results in increased expression of TES mRNA

NCBI chr 4:46,331,257...46,369,782
Ensembl chr 4:46,331,257...46,369,780

G

transferrin

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of TF mRNA

NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:112,647,642...112,695,400

G

trefoil factor 1

multiple interactions

ISO

TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of TFF1 mRNA]

NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,237,095...9,240,956

G

trefoil factor 3

increases expression

EXP

2-Acetylaminofluorene results in increased expression of TFF3 mRNA

NCBI chr20:9,194,623...9,199,333
Ensembl chr20:9,194,626...9,199,333

G

transferrin receptor

increases expression

EXP

2-Acetylaminofluorene results in increased expression of TFRC mRNA

NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318

G

transforming growth factor, beta 1

multiple interactions
increases expression

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TGFB1 protein; IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TGFB1 protein]
2-Acetylaminofluorene results in increased expression of TGFB1 mRNA

PMID:15368444 PMID:15940639

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

thyroid hormone receptor beta

increases activity

ISO

2-Acetylaminofluorene results in increased activity of THRB protein

NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680

G

Thy-1 cell surface antigen

increases expression

EXP

2-Acetylaminofluorene results in increased expression of THY1 protein

NCBI chr 8:53,286,396...53,291,541
Ensembl chr 8:53,286,148...53,291,540

G

TIMP metallopeptidase inhibitor 1

increases expression

EXP

2-Acetylaminofluorene results in increased expression of TIMP1 mRNA

NCBI chr X:3,766,509...3,772,578
Ensembl chr X:3,766,510...3,771,135

G

transketolase

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TKT mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TKT mRNA

PMID:14656948 PMID:16158176

NCBI chr16:5,729,381...5,755,170
Ensembl chr16:5,729,991...5,756,431

G

transmembrane protein 134

increases expression

ISO

2-Acetylaminofluorene results in increased expression of TMEM134 mRNA

NCBI chr 1:210,848,761...210,857,735
Ensembl chr 1:210,848,578...210,858,861

G

transmembrane protein 184C

increases expression

EXP

2-Acetylaminofluorene results in increased expression of TMEM184C mRNA

NCBI chr19:47,249,403...47,265,502
Ensembl chr19:47,249,500...47,265,949

G

transmembrane protein 43

increases expression

ISO

2-Acetylaminofluorene results in increased expression of TMEM43 mRNA

NCBI chr 4:125,534,844...125,549,986
Ensembl chr 4:125,534,813...125,549,988

G

tumor necrosis factor

multiple interactions
increases expression

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TNF protein; Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of TNF protein]

PMID:18271918 PMID:23665045 PMID:25051504

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

DNA topoisomerase II alpha

increases expression

EXP

2-Acetylaminofluorene results in increased expression of TOP2A mRNA

NCBI chr10:84,441,954...84,473,093
Ensembl chr10:84,441,954...84,473,366

G

tumor protein p53

increases expression
decreases expression
increases response to substance
multiple interactions

EXP
ISO

2-Acetylaminofluorene results in increased expression of TP53 protein
2-Acetylaminofluorene results in increased expression of TRP53 protein
2-Acetylaminofluorene results in decreased expression of TP53 protein
TRP53 protein modified form results in increased susceptibility to 2-Acetylaminofluorene
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of BAX mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of CCNB2 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of CDKN1A mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of EI24 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of PERP mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of PMAIP1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of RPRM mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of SERPINB5 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of ZMAT3 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of CYP4F15 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of MEG3 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of SLC25A4 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of TTR mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of ALDH3A1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of ANXA3 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of AREG mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of COL17A1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of CYP1B1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of HEBP2 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT15 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT23 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT4 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of LYPD3 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of NOS3 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of PADI2 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of PMAIP1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of SLC2A8 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of SPRR2F mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of TFF1 mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of TSHB mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of TUBA1C mRNA]; TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of UBE2C mRNA]
[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of and affects the localization of TP53 protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of TP53 protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of TP53 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TP53 protein; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TP53 protein]; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of TP53 protein]; Vanadium promotes the reaction [2-Acetylaminofluorene results in increased expression of TP53 protein]

PMID:7728945 PMID:9667752 PMID:10708481 PMID:11003613 PMID:11915028 More...

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tumor protein p53 inducible nuclear protein 1

multiple interactions
increases expression

EXP
ISO

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of TRP53INP1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of TRP53INP1 mRNA
2-Acetylaminofluorene results in increased expression of TP53INP1 mRNA
2-Acetylaminofluorene results in increased expression of TRP53INP1 mRNA

PMID:14656948 PMID:16158176 PMID:21607683 PMID:22584684

NCBI chr 5:29,051,267...29,069,486
Ensembl chr 5:29,051,264...29,069,484

G

tumor protein p73

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of TP73 mRNA

NCBI chr 5:169,903,801...169,988,075
Ensembl chr 5:169,903,801...169,963,552

G

transient receptor potential cation channel, subfamily M, member 2

multiple interactions

EXP

[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TRPM2 mRNA

NCBI chr20:10,703,190...10,752,795
Ensembl chr20:10,704,482...10,752,802

G

TSC22 domain family, member 1

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of TSC22D1 mRNA

NCBI chr15:58,159,612...58,260,244
Ensembl chr15:58,159,952...58,183,322

G

thyroid stimulating hormone subunit beta

multiple interactions

ISO

TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of TSHB mRNA]

NCBI chr 2:192,913,171...192,918,054
Ensembl chr 2:192,913,171...192,942,984

G

transthyretin

multiple interactions

ISO

TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of TTR mRNA]

NCBI chr18:12,216,684...12,225,972
Ensembl chr18:12,216,732...12,225,969

G

tubulin, alpha 1C

multiple interactions

ISO

TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of TUBA1C mRNA]

NCBI chr 7:131,636,974...132,078,589
Ensembl chr 7:132,070,536...132,079,311

G

tubulin, beta 4B class IVb

increases expression

ISO
EXP

2-Acetylaminofluorene results in increased expression of TUBB4B mRNA

PMID:21607683 PMID:22584684

NCBI chr 3:28,435,999...28,438,455
Ensembl chr 3:28,435,148...28,439,719

G

tubulin, beta 5 class I

increases expression

EXP

2-Acetylaminofluorene results in increased expression of TUBB5 mRNA

NCBI chr20:2,917,577...2,921,726
Ensembl chr20:2,917,539...2,921,726

G

tubulin, beta 6 class V

increases expression

ISO

2-Acetylaminofluorene results in increased expression of TUBB6 mRNA

NCBI chr18:63,213,287...63,222,926
Ensembl chr18:63,213,279...63,224,303

G

ubiquitin-conjugating enzyme E2C

increases expression
multiple interactions

ISO
EXP

2-Acetylaminofluorene results in increased expression of UBE2C mRNA
TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of UBE2C mRNA]

PMID:17317680 PMID:22584684

NCBI chr 3:173,925,975...173,928,375
Ensembl chr 3:173,925,934...173,932,678

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

ISO

UGT1A9 protein results in increased glucuronidation of 2-Acetylaminofluorene analog

NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

vascular cell adhesion molecule 1

increases expression

ISO
EXP

2-Acetylaminofluorene results in increased expression of VCAM1 mRNA
2-Acetylaminofluorene results in increased expression of VCAM1 protein

PMID:21607683 PMID:25051504

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801

G

vascular endothelial growth factor A

decreases expression
multiple interactions
increases expression

EXP

2-Acetylaminofluorene results in decreased expression of VEGFA mRNA
geraniol inhibits the reaction [2-Acetylaminofluorene results in increased expression of VEGFA protein]

PMID:22213190 PMID:25051504 PMID:26364502

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

WEE1 G2 checkpoint kinase

increases expression

EXP

2-Acetylaminofluorene results in increased expression of WEE1 mRNA

NCBI chr 1:173,605,609...173,632,450
Ensembl chr 1:173,608,949...173,632,449

G

WW domain-containing oxidoreductase

decreases expression

ISO

2-Acetylaminofluorene results in decreased expression of WWOX mRNA

NCBI chr19:59,338,402...60,269,323
Ensembl chr19:59,341,233...60,269,441

G

xanthine dehydrogenase

increases activity
multiple interactions

EXP

2-Acetylaminofluorene results in increased activity of XDH protein
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of XDH protein]

NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350

G

XPC complex subunit, DNA damage recognition and repair factor

decreases response to substance

ISO

XPC protein results in decreased susceptibility to 2-Acetylaminofluorene

NCBI chr 4:125,550,833...125,578,084
Ensembl chr 4:125,550,833...125,578,305

G

zinc finger E-box binding homeobox 1

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of ZEB1 protein

NCBI chr17:56,644,397...56,811,155
Ensembl chr17:56,644,397...56,810,745

G

zinc finger E-box binding homeobox 2

decreases expression

EXP

2-Acetylaminofluorene results in decreased expression of ZEB2 protein

NCBI chr 3:49,624,028...49,754,323
Ensembl chr 3:49,624,028...49,754,323

G

zinc finger, matrin type 3

multiple interactions
increases expression

ISO
EXP

TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of ZMAT3 mRNA]
2-Acetylaminofluorene results in increased expression of ZMAT3 mRNA

PMID:17070881 PMID:17317680 PMID:19167416 PMID:21607683 PMID:22584684

NCBI chr 2:117,034,517...117,066,141
Ensembl chr 2:117,034,517...117,065,294

N-acetoxy-2-acetamidofluorene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

tumor protein p53

multiple interactions

EXP

[Acetoxyacetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TP53 protein

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

N-hydroxy-2-acetamidofluorene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family B member 1B

increases expression

EXP

Hydroxyacetylaminofluorene results in increased expression of ABCB1B mRNA; Hydroxyacetylaminofluorene results in increased expression of ABCB1B protein

NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567

G

N-acetyltransferase 1

decreases activity

ISO

Hydroxyacetylaminofluorene results in decreased activity of NAT1 protein

NCBI chr16:26,984,882...27,005,194
Ensembl chr16:26,982,625...26,986,527

G

N-acetyltransferase 2

decreases activity

ISO

Hydroxyacetylaminofluorene results in decreased activity of NAT2 protein

NCBI chr16:26,974,874...27,005,191
Ensembl chr16:26,974,601...26,976,304

G

sulfotransferase family 2A member 1

increases sulfation

ISO

SULT2A1 protein results in increased sulfation of Hydroxyacetylaminofluorene

NCBI chr 1:84,582,011...84,639,001

G

tumor protein p53

increases expression

EXP

Hydroxyacetylaminofluorene results in increased expression of TP53 protein

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20874
role	20844
biological role	20831
xenobiotic	19528
fluorenes	435
2-acetamidofluorenes	430
2-acetamidofluorene	430
N-acetoxy-2-acetamidofluorene	1
N-hydroxy-2-acetamidofluorene	5
Path 2
Term	Annotations
CHEBI ontology	20874
subatomic particle	20883
composite particle	20883
hadron	20872
baryon	20883
nucleon	20872
atomic nucleus	20883
atom	20872
main group element atom	20796
p-block element atom	20796
carbon group element atom	20712
carbon atom	20706
organic molecular entity	20706
organic molecule	20499
organic cyclic compound	20390
carbocyclic compound	18739
carbopolycyclic compound	16424
carbotricyclic compound	1601
fluorenes	435
2-acetamidofluorenes	430
2-acetamidofluorene	430
N-acetoxy-2-acetamidofluorene	1
N-hydroxy-2-acetamidofluorene	5

paths to the root