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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4,5,4'-trihydroxy-3,3'-dimethoxybibenzyl
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Accession:CHEBI:193138 term browser browse the term
Definition:A diphenylethane that is 1,2-dihydrostilbene substituted by hydroxy groups at positions 4, 4', and 5 and a methoxy groups at positions 3 and 3'. It is isolated from Dendrobium ellipsophyllum and sensitizes lung cancer cells to anoikis.
Synonyms:exact_synonym: 5-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-3-methoxybenzene-1,2-diol
 related_synonym: 3',5-dimethoxybibenzyl-3,4,4'-triol;   Formula=C16H18O5;   InChI=1S/C16H18O5/c1-20-14-8-10(5-6-12(14)17)3-4-11-7-13(18)16(19)15(9-11)21-2/h5-9,17-19H,3-4H2,1-2H3;   InChIKey=DAQVNMKZMKBKOF-UHFFFAOYSA-N;   SMILES=COC1=CC(CCC2=CC(OC)=C(O)C(O)=C2)=CC=C1O;   TDB
 xref: PMID:21812336;   PMID:24692728;   PMID:26109451;   PMID:29488156;   PMID:33562174;   PMID:34349823;   PMID:35679136;   PMID:36094346


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4,5,4'-trihydroxy-3,3'-dimethoxybibenzyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rac1 Rac family small GTPase 1 decreases activity ISO TDB decreases activity of RAC1 protein in lung cancer cells RGD PMID:26109451 RGD:155791640 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
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  CHEBI ontology 19898
    role 19868
      application 19714
        pharmaceutical 19550
          drug 19550
            antineoplastic agent 17830
              4,5,4'-trihydroxy-3,3'-dimethoxybibenzyl 1
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  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19771
                          organic molecular entity 19771
                            organic molecule 19724
                              organic cyclic compound 19515
                                organic aromatic compound 19382
                                  phenols 18676
                                    benzenediols 9161
                                      catechols 3425
                                        4,5,4'-trihydroxy-3,3'-dimethoxybibenzyl 1
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