Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:6-Methoxyflavone
go back to main search page
Accession:CHEBI:193017 term browser browse the term
Synonyms:exact_synonym: 6-methoxy-2-phenylchromen-4-one
 related_synonym: Formula=C16H12O3;   InChI=1S/C16H12O3/c1-18-12-7-8-15-13(9-12)14(17)10-16(19-15)11-5-3-2-4-6-11/h2-10H,1H3;   InChIKey=XZQLSABETMKIGG-UHFFFAOYSA-N;   SMILES=O1C2=C(C(=O)C=C1C3=CC=CC=C3)C=C(OC)C=C2
 xref: CAS:26964-24-9;   Chemspider:129764;   KEGG:D81756;   LIPID_MAPS_instance:LMPK12110100
 xref_mesh: MESH:C000593132


show annotations for term's descendants           Sort by:
6-Methoxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aif1 allograft inflammatory factor 1 multiple interactions ISO 6-methoxyflavone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of AIF1 protein] CTD PMID:35272244 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 decreases expression ISO 6-methoxyflavone results in decreased expression of APAF1 mRNA CTD PMID:35400257 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO 6-methoxyflavone results in increased expression of ATF4 mRNA; 6-methoxyflavone results in increased expression of ATF4 protein CTD PMID:35400257 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Casp3 caspase 3 increases expression ISO 6-methoxyflavone results in increased expression of CASP3 mRNA CTD PMID:35400257 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 decreases expression ISO 6-methoxyflavone results in decreased expression of CASP9 mRNA CTD PMID:35400257 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO 6-methoxyflavone results in decreased expression of CCNA2 mRNA; 6-methoxyflavone results in decreased expression of CCNA2 protein CTD PMID:35246013 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO 6-methoxyflavone results in increased expression of CCND1 mRNA; 6-methoxyflavone results in increased expression of CCND1 protein CTD PMID:35246013 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 increases expression ISO 6-methoxyflavone results in increased expression of CCNE1 mRNA; 6-methoxyflavone results in increased expression of CCNE1 protein CTD PMID:35246013 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO 6-methoxyflavone results in decreased expression of CDK2 mRNA; 6-methoxyflavone results in decreased expression of CDK2 protein CTD PMID:35246013 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 increases expression ISO 6-methoxyflavone results in increased expression of CDK6 mRNA; 6-methoxyflavone results in increased expression of CDK6 protein CTD PMID:35246013 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO 6-methoxyflavone results in increased expression of CDKN1A mRNA; 6-methoxyflavone results in increased expression of CDKN1A protein CTD PMID:35246013 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO GSK2656157 inhibits the reaction [6-methoxyflavone results in increased expression of DDIT3 protein]
6-methoxyflavone results in increased expression of DDIT3 mRNA; 6-methoxyflavone results in increased expression of DDIT3 protein		 CTD PMID:35400257 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
decreases expression		 ISO 6-methoxyflavone results in decreased expression of and results in increased phosphorylation of EIF2AK3 protein; GSK2656157 inhibits the reaction [6-methoxyflavone results in increased phosphorylation of EIF2AK3 protein]
6-methoxyflavone results in decreased expression of EIF2AK3 mRNA		 CTD PMID:35400257 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO 6-methoxyflavone results in increased expression of and results in increased phosphorylation of EIF2S1 protein; GSK2656157 inhibits the reaction [6-methoxyflavone results in increased phosphorylation of EIF2S1 protein] CTD PMID:35400257 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO 6-methoxyflavone results in decreased expression of FAS mRNA CTD PMID:35400257 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO 6-methoxyflavone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 6-methoxyflavone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein]] CTD PMID:24078264 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864 		JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO 6-methoxyflavone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:24078264 NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944 		JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO 6-methoxyflavone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 6-methoxyflavone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein]]; 6-methoxyflavone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:24078264 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO 6-methoxyflavone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 6-methoxyflavone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:24078264 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
G Gabrr1 gamma-aminobutyric acid type A receptor subunit rho 1 multiple interactions ISO 6-methoxyflavone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of GABRR1 protein mutant form]; 6-methoxyflavone promotes the reaction [gamma-Aminobutyric Acid results in increased activity of GABRR1 protein] CTD PMID:24078264 NCBI chr 5:47,524,151...47,561,228
Ensembl chr 5:47,524,151...47,561,228 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [6-methoxyflavone co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of HMOX1 protein CTD PMID:35272244 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Ifng interferon gamma multiple interactions ISO 6-methoxyflavone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG mRNA] CTD PMID:25114106 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO 6-methoxyflavone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL10 mRNA]; 6-methoxyflavone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL10 protein] CTD PMID:25114106 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il13 interleukin 13 multiple interactions ISO 6-methoxyflavone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL13 mRNA] CTD PMID:25114106 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 6-methoxyflavone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL1B protein] CTD PMID:35272244 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO 6-methoxyflavone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [NFATC2 protein binds to IL4 promoter]]; 6-methoxyflavone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 mRNA]; 6-methoxyflavone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 protein] CTD PMID:25114106 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO 6-methoxyflavone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL6 protein] CTD PMID:35272244 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO 6-methoxyflavone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK8 protein] CTD PMID:35272244 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO 6-methoxyflavone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of MYD88 protein] CTD PMID:35272244 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nfatc2 nuclear factor of activated T-cells 2 multiple interactions ISO 6-methoxyflavone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the localization of NFATC2 protein]; 6-methoxyflavone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] promotes the reaction [NFATC2 protein binds to IL4 promoter]] CTD PMID:25114106 NCBI chr 3:157,195,970...157,328,640
Ensembl chr 3:157,198,872...157,328,325 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 6-methoxyflavone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein] CTD PMID:35272244 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 6-methoxyflavone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein] CTD PMID:35272244 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [6-methoxyflavone co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NQO1 protein CTD PMID:35272244 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 6-methoxyflavone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein] CTD PMID:35272244 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 6-methoxyflavone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein] CTD PMID:35272244 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO 6-methoxyflavone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TLR4 protein] CTD PMID:35272244 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 6-methoxyflavone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein] CTD PMID:35272244 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A decreases expression ISO 6-methoxyflavone results in decreased expression of TNFRSF1A mRNA CTD PMID:35400257 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 decreases expression ISO 6-methoxyflavone results in decreased expression of TRAF2 mRNA CTD PMID:35400257 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    chemical entity 19897
      atom 19897
        nonmetal atom 19819
          carbon atom 19772
            organic molecular entity 19772
              flavonoids 11636
                6-Methoxyflavone 39
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            heteroorganic entity 19532
                              organochalcogen compound 19293
                                organooxygen compound 19209
                                  ether 17328
                                    6-Methoxyflavone 39
paths to the root