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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:varespladib methyl
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Accession:CHEBI:192805 term browser browse the term
Definition:A methyl ester resulting from the formal condensation of the carboxy group of varespladib with methanol. It is a potential therapy for the treatment of snakebite envenomings in which toxicity depends on the action of PLA2s.
Synonyms:exact_synonym: methyl ({3-[amino(oxo)acetyl]-1-benzyl-2-ethyl-1H-indol-4-yl}oxy)acetate
 related_synonym: A-002;   Formula=C22H22N2O5;   InChI=1S/C22H22N2O5/c1-3-15-20(21(26)22(23)27)19-16(24(15)12-14-8-5-4-6-9-14)10-7-11-17(19)29-13-18(25)28-2/h4-11H,3,12-13H2,1-2H3,(H2,23,27);   InChIKey=VJYDOJXJUCJUHL-UHFFFAOYSA-N;   LY-333013;   LY333013;   S 3013;   S3013;   SMILES=CCC1=C(C(=O)C(N)=O)C2=C(OCC(=O)OC)C=CC=C2N1CC1=CC=CC=C1;   varespladib methyl ester
 xref: CAS:172733-08-3;   Chemspider:8062590;   DrugBank:DB05737;   HMDB:HMDB0259767;   KEGG:D08221
 xref_mesh: MESH:C545088
 xref: PMID:15742431;   PMID:19697278;   PMID:20809869;   PMID:20863951;   PMID:21174506;   PMID:21446779;   PMID:21989792;   PMID:27571102;   PMID:30241297;   PMID:30453607;   PMID:31146670;   PMID:31226842;   PMID:32093386;   PMID:32560391;   PMID:32889027;   PMID:34143707


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varespladib methyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions ISO varespladib methyl inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA]; varespladib methyl inhibits the reaction [IL1B protein results in increased expression of MMP2 mRNA]; varespladib methyl inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; varespladib methyl inhibits the reaction [IL1B protein results in increased expression of MMP9 mRNA]; varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of MMP1 protein]; varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of MMP2 protein]; varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein]; varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of MMP9 protein]; varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of PLA2G2A protein] CTD PMID:19765281 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO varespladib methyl inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA]; varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of MMP1 protein] CTD PMID:19765281 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO varespladib methyl inhibits the reaction [IL1B protein results in increased expression of MMP2 mRNA]; varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of MMP2 protein] CTD PMID:19765281 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO varespladib methyl inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein] CTD PMID:19765281 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO varespladib methyl inhibits the reaction [IL1B protein results in increased expression of MMP9 mRNA]; varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of MMP9 protein] CTD PMID:19765281 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Pla2g2a phospholipase A2 group IIA multiple interactions ISO varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of PLA2G2A protein] CTD PMID:19765281 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      application 19714
        anti-inflammatory agent 16684
          anti-inflammatory drug 14974
            varespladib methyl 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19771
                          organic molecular entity 19771
                            heteroorganic entity 19528
                              organochalcogen compound 19290
                                organooxygen compound 19206
                                  carbon oxoacid 18675
                                    carboxylic acid 18672
                                      carboacyl group 17712
                                        univalent carboacyl group 17712
                                          carbamoyl group 17563
                                            carboxamide 17563
                                              dicarboxylic acid amide 3153
                                                dicarboxylic acid monoamide 683
                                                  varespladib 8
                                                    varespladib methyl 6
paths to the root