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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:harmol
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Accession:CHEBI:192558 term browser browse the term
Definition:A 9H-beta-carboline carrying a methyl substituent at C-1 and a hydroxy group at C-7; major microspecies at pH 7.3.
Synonyms:exact_synonym: 1-methyl-9H-beta-carbolin-7-ol
 related_synonym: 1-methyl-9H-pyrido[3,4-b]indol-7-ol;   Formula=C12H10N2O;   InChI=1S/C12H10N2O/c1-7-12-10(4-5-13-7)9-3-2-8(15)6-11(9)14-12/h2-6,14-15H,1H3;   InChIKey=SATMZMMKDDTOSQ-UHFFFAOYSA-N;   SMILES=CC1=NC=CC2=C1NC1=C2C=CC(O)=C1
 xref: CAS:487-03-6;   FooDB:FDB012520;   HMDB:HMDB0034217;   KNApSAcK:C00042574
 xref_mesh: MESH:C001326
 xref: MetaCyc:CPD-9941;   PMID:19318910;   PMID:21804216;   PMID:22001777;   PMID:23338618;   PMID:28326067;   PMID:35767141;   PMID:35933473;   Wikipedia:Harmol


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harmol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO harmol inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein] CTD PMID:22001777 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
decreases stability		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [harmol results in decreased stability of CYP1A1 protein]; harmol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; harmol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
harmol results in decreased activity of CYP1A1 protein		 CTD PMID:22001777 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions EXP
ISO		 Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of harmol] CTD PMID:11181495 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        biochemical role 19549
          autophagy inducer 2096
            harmol 3
              6-(3-dimethylallyl)harmol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic heterocyclic compound 18868
                                  organic heteropolycyclic compound 18294
                                    organic heterotricyclic compound 15841
                                      pyridoindole 136
                                        beta-carbolines 117
                                          beta-carboline 23
                                            harmol 3
                                              6-(3-dimethylallyl)harmol 0
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