The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
An organic heterobicyclic compound that is (1R,5S)-2-oxabicyclo[3.1.0]hexane carrying amino, carboxy, and carboxy groups at positions 4R, 4R and 6R, respectively. It is a potent agonist of group II metabotropic glutamate receptors mGluR2 and mGluR3 (EC50 = 2.69 nM and 4.48 nM, respectively) that exhibits antipsychotic-like action in animal models of schizophrenia.
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LY 379268 results in increased phosphorylation of BAD protein]; U 0126 inhibits the reaction [LY 379268 results in increased phosphorylation of BAD protein]
LY 379268 results in increased expression of BCL2L1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LY 379268 results in increased expression of BCL2L1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LY 379268 inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]]; LY 379268 inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]; U 0126 inhibits the reaction [LY 379268 inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LY 379268 results in increased phosphorylation of MAPK1 protein]; LY 341495 inhibits the reaction [LY 379268 results in increased phosphorylation of MAPK1 protein]; Pertussis Toxin inhibits the reaction [LY 379268 results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [LY 379268 results in increased phosphorylation of MAPK1 protein]
LY 379268 results in increased phosphorylation of MAPK3 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LY 379268 results in increased phosphorylation of MAPK3 protein]; LY 341495 inhibits the reaction [LY 379268 results in increased phosphorylation of MAPK3 protein]; Pertussis Toxin inhibits the reaction [LY 379268 results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [LY 379268 results in increased phosphorylation of MAPK3 protein]
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