elicitor - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	elicitor	go back to main search page
Accession:	CHEBI:192504	browse the term
Definition:	A chemical or biochemical compound that is introduced in small concentrations to a living system to promote the biosynthesis of the target bioactive compound.
Synonyms:	related_synonym:	elicitors
	xref:	PMID:25969762; Wikipedia:Elicitor

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Rat (63) Mouse (62) Human (63) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (63)

chitosan

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

multiple interactions

[Chitosan co-treated with Fish Oils] inhibits the reaction [Dietary Fats results in decreased expression of ABCA1 mRNA]; Chitosan inhibits the reaction [Dietary Fats results in decreased expression of ABCA1 mRNA]

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

AKT serine/threonine kinase 1

multiple interactions
decreases phosphorylation

[Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of AKT1 protein]
Chitosan results in decreased phosphorylation of AKT1 protein

PMID:28732690 PMID:36706893

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aminolevulinate dehydratase

multiple interactions

[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of ALAD protein]

NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474

G

alkaline phosphatase, biomineralization associated

increases expression

Chitosan results in increased expression of ALPL mRNA; Chitosan results in increased expression of ALPL protein

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

aldehyde oxidase 1

multiple interactions

[Chitosan co-treated with Fish Oils] inhibits the reaction [Dietary Fats results in decreased expression of AOX1 mRNA]; Chitosan inhibits the reaction [Dietary Fats results in decreased expression of AOX1 mRNA]

NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770

G

ARB2 cotranscriptional regulator A

multiple interactions
increases expression

ARB2A protein affects the reaction [Chitosan results in decreased expression of CPE protein]; ARB2A protein affects the reaction [Chitosan results in decreased expression of MMP9 protein]; ARB2A protein affects the reaction [Chitosan results in decreased phosphorylation of MAPK1 protein]; ARB2A protein affects the reaction [Chitosan results in decreased phosphorylation of MAPK3 protein]
Chitosan results in increased expression of ARB2A mRNA

NCBI chr 2:7,553,873...8,018,183
Ensembl chr 2:7,553,891...8,018,162

G

BCL2 associated X, apoptosis regulator

multiple interactions

[Fluorouracil co-treated with Chitosan co-treated with polyaspartate] results in increased expression of BAX protein
[Rutin co-treated with Chitosan] inhibits the reaction [Cyclophosphamide results in increased expression of BAX mRNA]; Chitosan analog inhibits the reaction [Doxorubicin results in increased expression of BAX protein]

PMID:18567086 PMID:30928397 PMID:38211767

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

[Fluorouracil co-treated with Chitosan co-treated with polyaspartate] results in decreased expression of BCL2 protein
[Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of BCL2 protein]; [Rutin co-treated with Chitosan] inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 mRNA]; Chitosan analog inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]

PMID:18567086 PMID:28732690 PMID:30928397 PMID:38211767

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

bone gamma-carboxyglutamate protein

increases expression

Chitosan results in increased expression of BGLAP mRNA

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

caspase 2

multiple interactions

Chitosan promotes the reaction [Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP2 mRNA]]

NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379

G

caspase 3

multiple interactions

Chitosan metabolite inhibits the reaction [Copper results in increased activity of CASP3 protein]
Chitosan analog inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; Chitosan inhibits the reaction [carbendazim results in increased expression of CASP3 protein]; Chitosan promotes the reaction [Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP3 mRNA]]

PMID:25542178 PMID:30928397 PMID:35705592 PMID:38369055

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

multiple interactions

Chitosan promotes the reaction [Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP7 mRNA]]

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 9

multiple interactions

Chitosan analog inhibits the reaction [Doxorubicin results in increased expression of CASP9 protein]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

[Chitosan analog co-treated with Quercetin] inhibits the reaction [ochratoxin A results in decreased activity of CAT protein]; [Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of CAT protein]; Chitosan analog inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; Chitosan analog inhibits the reaction [ochratoxin A results in decreased activity of CAT protein]; Chitosan inhibits the reaction [carbendazim results in decreased expression of CAT protein]; Chitosan inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]

PMID:12679053 PMID:22704994 PMID:27923682 PMID:30928397 PMID:35705592

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-type lectin domain containing 7A

multiple interactions
decreases expression

Chitosan inhibits the reaction [Lipopolysaccharides results in decreased expression of CLEC7A mRNA]
Chitosan results in decreased expression of CLEC7A mRNA

NCBI chr 4:162,902,731...162,913,931
Ensembl chr 4:162,902,732...162,913,897

G

collagen type XV alpha 1 chain

decreases expression

Chitosan results in decreased expression of COL15A1 mRNA

NCBI chr 5:61,501,963...61,607,591
Ensembl chr 5:61,501,963...61,607,591

G

carboxypeptidase E

decreases expression
multiple interactions

Chitosan results in decreased expression of CPE mRNA; Chitosan results in decreased expression of CPE protein
ARB2A protein affects the reaction [Chitosan results in decreased expression of CPE protein]

NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233

G

catenin beta 1

multiple interactions

[Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of CTNNB1 protein]

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cytochrome P450, family 11, subfamily a, polypeptide 1

multiple interactions

[Rutin co-treated with Chitosan] inhibits the reaction [Cyclophosphamide results in decreased expression of CYP11A1 mRNA]

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases activity

Chitosan analog results in increased activity of CYP3A4 protein

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450 family 7 subfamily A member 1

multiple interactions

Chitosan inhibits the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA]; Fish Oils promotes the reaction [Chitosan inhibits the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA]]

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

dickkopf WNT signaling pathway inhibitor 1

increases expression

Chitosan results in increased expression of DKK1 mRNA

NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202

G

fatty acid binding protein 4

multiple interactions

[Fish Oils co-treated with Chitosan] inhibits the reaction [Dietary Fats results in increased expression of FABP4 mRNA]; Chitosan inhibits the reaction [Dietary Fats results in increased expression of FABP4 mRNA]

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

fatty acid synthase

multiple interactions

[Fish Oils co-treated with Chitosan] inhibits the reaction [Dietary Fats results in increased expression of FASN mRNA]; Chitosan inhibits the reaction [Dietary Fats results in increased expression of FASN mRNA]

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

forkhead box O3

decreases phosphorylation

Chitosan results in decreased phosphorylation of FOXO3 protein

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

glucagon

increases expression
multiple interactions
increases secretion

Chitosan results in increased expression of GCG mRNA
SB 203580 inhibits the reaction [Chitosan results in increased expression of GCG mRNA]; SB 203580 inhibits the reaction [Chitosan results in increased secretion of GCG protein]

NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929

G

glutamic-oxaloacetic transaminase 1

multiple interactions

Chitosan inhibits the reaction [carbendazim results in increased secretion of GOT1 protein]

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glutamic--pyruvic transaminase

multiple interactions

Chitosan inhibits the reaction [carbendazim results in increased secretion of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 1

increases expression
multiple interactions

Chitosan analog results in increased expression of GPX1 mRNA
[Chitosan analog co-treated with Quercetin] inhibits the reaction [ochratoxin A results in decreased expression of GPX1 mRNA]; [Chitosan analog co-treated with Quercetin] results in increased expression of GPX1 mRNA; Chitosan analog inhibits the reaction [ochratoxin A results in decreased expression of GPX1 mRNA]

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

gasdermin D

multiple interactions

Chitosan promotes the reaction [Curcumin inhibits the reaction [fenpropathrin results in decreased expression of GSDMD mRNA]]

NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055

G

glycogen synthase kinase 3 beta

multiple interactions

[Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of GSK3B protein]

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

glutathione-disulfide reductase

multiple interactions

Chitosan analog inhibits the reaction [Doxorubicin results in decreased expression of GSR mRNA]

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions

[Fish Oils co-treated with Chitosan] inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA]; Chitosan inhibits the reaction [Dietary Fats results in increased expression of HMGCR mRNA]

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

heme oxygenase 1

multiple interactions

[Chitosan metabolite results in decreased susceptibility to Copper] which results in increased expression of HMOX1 mRNA; [Chitosan metabolite results in decreased susceptibility to Copper] which results in increased expression of HMOX1 protein
Chitosan analog inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 mRNA]; Chitosan inhibits the reaction [carbendazim results in decreased expression of HMOX1 mRNA]

PMID:25542178 PMID:30928397 PMID:35705592

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

interleukin 10

multiple interactions
increases secretion

Chitosan inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]
Chitosan results in increased secretion of IL10 protein

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

multiple interactions

Chitosan promotes the reaction [Curcumin inhibits the reaction [fenpropathrin results in increased expression of IL1B mRNA]]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

increases secretion
multiple interactions

Chitosan results in increased secretion of IL6 protein
Chitosan inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

Kelch-like ECH-associated protein 1

multiple interactions

Chitosan inhibits the reaction [carbendazim results in increased expression of KEAP1 mRNA]

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation

ARB2A protein affects the reaction [Chitosan results in decreased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation

[Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of MAPK3 protein]
ARB2A protein affects the reaction [Chitosan results in decreased phosphorylation of MAPK3 protein]

PMID:28732690 PMID:36706893

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

matrix metallopeptidase 2

multiple interactions

Chitosan inhibits the reaction [Aminolevulinic Acid analog results in increased activity of MMP2 protein]

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions
decreases expression

ARB2A protein affects the reaction [Chitosan results in decreased expression of MMP9 protein]
Chitosan results in decreased expression of MMP9 mRNA; Chitosan results in decreased expression of MMP9 protein

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

NFE2 like bZIP transcription factor 2

multiple interactions
affects localization

[Chitosan metabolite results in decreased susceptibility to Copper] which results in increased phosphorylation of NFE2L2 protein
Chitosan analog affects the localization of NFE2L2 protein
[Rutin co-treated with Chitosan] inhibits the reaction [Cyclophosphamide results in decreased expression of NFE2L2 mRNA]; Chitosan analog inhibits the reaction [Doxorubicin affects the localization of NFE2L2 protein]; Chitosan inhibits the reaction [carbendazim results in decreased expression of NFE2L2 mRNA]; pyrazolanthrone inhibits the reaction [Chitosan analog inhibits the reaction [Doxorubicin affects the localization of NFE2L2 protein]]; SB 203580 inhibits the reaction [Chitosan analog inhibits the reaction [Doxorubicin affects the localization of NFE2L2 protein]]

PMID:25542178 PMID:30928397 PMID:35705592 PMID:38211767

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NLR family, pyrin domain containing 3

multiple interactions

Chitosan promotes the reaction [Curcumin inhibits the reaction [fenpropathrin results in increased expression of NLRP3 mRNA]]

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

nitric oxide synthase 2

multiple interactions

Chitosan inhibits the reaction [carbendazim results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

Chitosan analog inhibits the reaction [Doxorubicin results in decreased expression of NQO1 mRNA]

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 1, group H, member 3

multiple interactions

[Chitosan co-treated with Fish Oils] inhibits the reaction [Dietary Fats results in increased expression of NR1H3 protein]

NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

decreases phosphorylation

Chitosan results in decreased phosphorylation of PIK3CA protein

NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032

G

phosphoinositide-3-kinase regulatory subunit 1

decreases phosphorylation

Chitosan results in decreased phosphorylation of PIK3R1 protein

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

peroxisome proliferator activated receptor alpha

multiple interactions

[Chitosan co-treated with Fish Oils] inhibits the reaction [Dietary Fats results in decreased expression of PPARA protein]

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

PPARG coactivator 1 alpha

increases expression

Chitosan results in increased expression of PPARGC1A mRNA

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

[Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of RELA protein]; Chitosan promotes the reaction [Curcumin inhibits the reaction [fenpropathrin results in increased expression of RELA mRNA]]

PMID:28732690 PMID:38369055

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

RUNX family transcription factor 2

increases expression

Chitosan results in increased expression of RUNX2 mRNA; Chitosan results in increased expression of RUNX2 protein

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

superoxide dismutase 1

multiple interactions
increases expression

[Chitosan analog co-treated with Quercetin] results in increased expression of SOD1 mRNA; Chitosan analog inhibits the reaction [Doxorubicin results in decreased expression of SOD1 mRNA]
Chitosan analog results in increased expression of SOD1 mRNA

PMID:27923682 PMID:30928397

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

SPARC like 1

decreases expression

Chitosan results in decreased expression of SPARCL1 mRNA

NCBI chr14:5,632,816...5,663,866
Ensembl chr14:5,632,569...5,663,865

G

secreted phosphoprotein 1

increases expression

Chitosan results in increased expression of SPP1 mRNA

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

sterol regulatory element binding transcription factor 1

multiple interactions

[Fish Oils co-treated with Chitosan] inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]; Chitosan inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

steroidogenic acute regulatory protein

multiple interactions

[Rutin co-treated with Chitosan] inhibits the reaction [Cyclophosphamide results in decreased expression of STAR mRNA]

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

tyrosine hydroxylase

multiple interactions

[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TH protein]

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

toll-like receptor 2

multiple interactions
decreases expression

Chitosan inhibits the reaction [Lipopolysaccharides results in decreased expression of TLR2 mRNA]
Chitosan results in decreased expression of TLR2 mRNA

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

G

toll-like receptor 4

decreases expression
multiple interactions

Chitosan results in decreased expression of TLR4 mRNA
Chitosan inhibits the reaction [Lipopolysaccharides results in decreased expression of TLR4 mRNA]

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

multiple interactions
increases secretion

Chitosan inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Chitosan results in increased secretion of TNF protein

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tryptophan hydroxylase 1

multiple interactions

[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TPH1 protein]

NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19880
role	19850
biological role	19848
biochemical role	19556
elicitor	63
chitosan	63

paths to the root