CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: Cirsimarin
Accession: CHEBI:192417
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Synonyms: exact_synonym: 5-hydroxy-6,7-dimethoxy-2-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]chromen-4-one
related_synonym: Formula=C23H24O11; InChI=1S/C23H24O11/c1-30-15-8-14-17(19(27)22(15)31-2)12(25)7-13(33-14)10-3-5-11(6-4-10)32-23-21(29)20(28)18(26)16(9-24)34-23/h3-8,16,18,20-21,23-24,26-29H,9H2,1-2H3/t16-,18-,20+,21-,23-/m1/s1; InChIKey=RETJLKUBHXTIGH-FZFRBNDOSA-N; SMILES=O1[C@@H]([C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC2=CC=C(C=C2)C=3OC=4C(C(=O)C3)=C(O)C(OC)=C(OC)C4)CO
xref: CAS:13020-19-4; Chemspider:140227
xref_mesh: MESH:C107783
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Bax
BCL2 associated X, apoptosis regulator
decreases expression
ISO
cirsimarin results in decreased expression of BAX mRNA
CTD
PMID:35710092
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2l1
Bcl2-like 1
decreases expression
ISO
cirsimarin results in decreased expression of BCL2L1 mRNA
CTD
PMID:35710092
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Birc5
baculoviral IAP repeat-containing 5
decreases expression
ISO
cirsimarin results in decreased expression of BIRC5 mRNA
CTD
PMID:35710092
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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Casp9
caspase 9
decreases expression
ISO
cirsimarin results in decreased expression of CASP9 mRNA
CTD
PMID:35710092
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Ccna2
cyclin A2
decreases expression
ISO
cirsimarin results in decreased expression of CCNA2 mRNA
CTD
PMID:35710092
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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Ccnd1
cyclin D1
decreases expression
ISO
cirsimarin results in decreased expression of CCND1 mRNA
CTD
PMID:35710092
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Ccr5
C-C motif chemokine receptor 5
decreases expression
ISO
cirsimarin results in decreased expression of CCR5 mRNA
CTD
PMID:35710092
NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
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Cdh1
cadherin 1
decreases expression
ISO
cirsimarin results in decreased expression of CDH1 mRNA
CTD
PMID:35710092
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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Cdk2
cyclin dependent kinase 2
decreases expression
ISO
cirsimarin results in decreased expression of CDK2 mRNA
CTD
PMID:35710092
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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Cdk4
cyclin-dependent kinase 4
decreases expression
ISO
cirsimarin results in decreased expression of CDK4 mRNA
CTD
PMID:35710092
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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Ifnb1
interferon beta 1
multiple interactions
ISO
cirsimarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNB1 mRNA]
CTD
PMID:30053449
NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
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Il6
interleukin 6
multiple interactions
ISO
cirsimarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 mRNA]; cirsimarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
CTD
PMID:30053449
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Irf3
interferon regulatory factor 3
multiple interactions
ISO
cirsimarin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein]
CTD
PMID:30053449
NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
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Jak1
Janus kinase 1
multiple interactions
ISO
cirsimarin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein]
CTD
PMID:30053449
NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
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Jak2
Janus kinase 2
multiple interactions
ISO
cirsimarin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JAK2 protein]
CTD
PMID:30053449
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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Mmp11
matrix metallopeptidase 11
decreases expression
ISO
cirsimarin results in decreased expression of MMP11 mRNA
CTD
PMID:35710092
NCBI chr20:12,730,846...12,739,629
Ensembl chr20:12,730,836...12,739,628
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Mmp9
matrix metallopeptidase 9
decreases expression
ISO
cirsimarin results in decreased expression of MMP9 mRNA
CTD
PMID:35710092
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
cirsimarin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; cirsimarin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD
PMID:30053449
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
cirsimarin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; cirsimarin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
CTD
PMID:30053449
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Stat1
signal transducer and activator of transcription 1
multiple interactions
ISO
cirsimarin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]
CTD
PMID:30053449
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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Stat3
signal transducer and activator of transcription 3
multiple interactions
ISO
cirsimarin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]
CTD
PMID:30053449
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Tnf
tumor necrosis factor
multiple interactions decreases expression
ISO
cirsimarin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF mRNA]; cirsimarin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] cirsimarin results in decreased expression of TNF mRNA
CTD
PMID:30053449 PMID:35710092
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tp53
tumor protein p53
decreases expression
ISO
cirsimarin results in decreased expression of TP53 mRNA
CTD
PMID:35710092
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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