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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Cirsimarin
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Accession:CHEBI:192417 term browser browse the term
Synonyms:exact_synonym: 5-hydroxy-6,7-dimethoxy-2-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]chromen-4-one
 related_synonym: Formula=C23H24O11;   InChI=1S/C23H24O11/c1-30-15-8-14-17(19(27)22(15)31-2)12(25)7-13(33-14)10-3-5-11(6-4-10)32-23-21(29)20(28)18(26)16(9-24)34-23/h3-8,16,18,20-21,23-24,26-29H,9H2,1-2H3/t16-,18-,20+,21-,23-/m1/s1;   InChIKey=RETJLKUBHXTIGH-FZFRBNDOSA-N;   SMILES=O1[C@@H]([C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC2=CC=C(C=C2)C=3OC=4C(C(=O)C3)=C(O)C(OC)=C(OC)C4)CO
 xref: CAS:13020-19-4;   Chemspider:140227
 xref_mesh: MESH:C107783



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Cirsimarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO cirsimarin results in decreased expression of BAX mRNA CTD PMID:35710092 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO cirsimarin results in decreased expression of BCL2L1 mRNA CTD PMID:35710092 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO cirsimarin results in decreased expression of BIRC5 mRNA CTD PMID:35710092 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Casp9 caspase 9 decreases expression ISO cirsimarin results in decreased expression of CASP9 mRNA CTD PMID:35710092 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO cirsimarin results in decreased expression of CCNA2 mRNA CTD PMID:35710092 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO cirsimarin results in decreased expression of CCND1 mRNA CTD PMID:35710092 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 decreases expression ISO cirsimarin results in decreased expression of CCR5 mRNA CTD PMID:35710092 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
JBrowse link
G Cdh1 cadherin 1 decreases expression ISO cirsimarin results in decreased expression of CDH1 mRNA CTD PMID:35710092 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO cirsimarin results in decreased expression of CDK2 mRNA CTD PMID:35710092 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO cirsimarin results in decreased expression of CDK4 mRNA CTD PMID:35710092 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO cirsimarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNB1 mRNA] CTD PMID:30053449 NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Il6 interleukin 6 multiple interactions ISO cirsimarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 mRNA]; cirsimarin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:30053449 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO cirsimarin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein] CTD PMID:30053449 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
JBrowse link
G Jak1 Janus kinase 1 multiple interactions ISO cirsimarin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein] CTD PMID:30053449 NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO cirsimarin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JAK2 protein] CTD PMID:30053449 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Mmp11 matrix metallopeptidase 11 decreases expression ISO cirsimarin results in decreased expression of MMP11 mRNA CTD PMID:35710092 NCBI chr20:12,730,846...12,739,629
Ensembl chr20:12,730,836...12,739,628
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO cirsimarin results in decreased expression of MMP9 mRNA CTD PMID:35710092 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO cirsimarin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; cirsimarin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:30053449 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO cirsimarin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; cirsimarin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:30053449 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO cirsimarin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein] CTD PMID:30053449 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO cirsimarin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein] CTD PMID:30053449 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO cirsimarin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF mRNA]; cirsimarin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
cirsimarin results in decreased expression of TNF mRNA
CTD PMID:30053449 PMID:35710092 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 decreases expression ISO cirsimarin results in decreased expression of TP53 mRNA CTD PMID:35710092 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19915
    chemical entity 19913
      atom 19895
        nonmetal atom 19817
          oxygen atom 19555
            oxygen molecular entity 19574
              flavonoids 11632
                Cirsimarin 23
Path 2
Term Annotations click to browse term
  CHEBI ontology 19915
    subatomic particle 19913
      composite particle 19895
        hadron 19895
          baryon 19913
            nucleon 19895
              atomic nucleus 19913
                atom 19895
                  main group element atom 19852
                    p-block element atom 19834
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            heteroorganic entity 19542
                              organochalcogen compound 19302
                                organooxygen compound 19218
                                  carbohydrates and carbohydrate derivatives 15304
                                    carbohydrate 15286
                                      carbohydrate derivative 14300
                                        glycosyl compound 13065
                                          glycoside 11848
                                            Cirsimarin 23
paths to the root