17-oxo steroid - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	17-oxo steroid	go back to main search page
Accession:	CHEBI:19168	browse the term
Definition:	Any oxo steroid carrying the oxo group at position 17.
Synonyms:	related_synonym:	17-keto steroid; 17-keto steroids; 17-ketosteroid; 17-ketosteroids; 17-oxo steroids; 17-oxosteroid; 17-oxosteroids; Formula=C18H27OR; SMILES=CC12CCC3C(CCC4CCCCC34[*])C1CCC2=O; a 17-oxo steroid

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Genes (268)

2-hydroxyestrone

term browser

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Object Name

Qualifiers

Evidence

Notes

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PubMed Reference(s)

RGD Reference(s)

Position

G

creatine kinase B

multiple interactions

2-hydroxyestrone inhibits the reaction [Estradiol results in increased expression of CKB]

NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315

G

estrogen receptor 1

affects binding
multiple interactions

2-hydroxyestrone binds to ESR1 protein
2-hydroxyestrone binds to and results in increased activity of ESR1 protein

PMID:16728493 PMID:17713618

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions

2-hydroxyestrone binds to and results in increased activity of ESR2 protein

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

follicle stimulating hormone subunit beta

decreases expression

2-hydroxyestrone results in decreased expression of FSHB protein

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

luteinizing hormone subunit beta

decreases expression

2-hydroxyestrone results in decreased expression of LHB protein

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation

UGT1A1 protein results in increased glucuronidation of 2-hydroxyestrone

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases glucuronidation

UGT1A3 protein results in increased glucuronidation of 2-hydroxyestrone

NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of 2-hydroxyestrone

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

2-methoxyestrone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

hydroxysteroid (17-beta) dehydrogenase 2

multiple interactions

[HSD17B2 protein results in increased metabolism of and results in decreased activity of 2-methoxyestradiol] which results in increased chemical synthesis of 2-methoxyestrone

NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202

3alpha-hydroxy-5beta-androstan-17-one

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldo-keto reductase family 1, member D1

multiple interactions
increases chemical synthesis

[AKR1D1 protein alternative form results in increased metabolism of androstane-3,17-dione] which results in increased chemical synthesis of Etiocholanolone; [AKR1D1 protein alternative form results in increased reduction of Androstenedione] which results in increased chemical synthesis of Etiocholanolone; [AKR1D1 protein results in increased metabolism of androstane-3,17-dione] which results in increased chemical synthesis of Etiocholanolone; [AKR1D1 protein results in increased reduction of Androstenedione] which results in increased chemical synthesis of Etiocholanolone
AKR1D1 protein alternative form results in increased chemical synthesis of Etiocholanolone; AKR1D1 protein results in increased chemical synthesis of Etiocholanolone

NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372

G

UDP glycosyltransferase 2 family, polypeptide B

increases glucuronidation

UGT2B protein results in increased glucuronidation of Etiocholanolone

NCBI chr14:20,630,572...20,665,062
Ensembl chr14:20,630,250...20,651,776

4-hydroxyestrone

term browser

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Object Name

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Evidence

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Source

PubMed Reference(s)

RGD Reference(s)

Position

G

NFE2 like bZIP transcription factor 2

decreases expression
decreases response to substance

4-hydroxyestrone results in decreased expression of NFE2L2 mRNA
NFE2L2 protein results in decreased susceptibility to 4-hydroxyestrone

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation

UGT1A1 protein results in increased glucuronidation of 4-hydroxyestrone

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases glucuronidation

UGT1A3 protein results in increased glucuronidation of 4-hydroxyestrone

NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of 4-hydroxyestrone

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 2 member B7

increases glucuronidation

UGT2B7 protein alternative form results in increased glucuronidation of 4-hydroxyestrone; UGT2B7 protein results in increased glucuronidation of 4-hydroxyestrone

PMID:8423545 PMID:8517101

NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604

adrenosterone

term browser

Symbol

Object Name

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Evidence

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Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22 member 2

multiple interactions

adrenosterone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

andrastin A

term browser

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Object Name

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PubMed Reference(s)

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G

colony stimulating factor 2

multiple interactions

andrastin A results in increased expression of and results in increased secretion of CSF2 protein

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

transforming growth factor, beta 1

multiple interactions

andrastin A results in increased expression of and results in increased secretion of TGFB1 protein

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

multiple interactions

andrastin A results in increased expression of and results in increased secretion of TNF protein

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

androst-4-ene-3,17-dione

term browser

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Object Name

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PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily G member 2

multiple interactions
decreases activity

Androstenedione inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate]
Androstenedione results in decreased activity of ABCG2 protein

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

ATP binding cassette subfamily G member 5

multiple interactions

Androstenedione results in increased activity of [ABCG5 protein binds to ABCG8 protein]

NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563

G

ATP binding cassette subfamily G member 8

multiple interactions

Androstenedione results in increased activity of [ABCG5 protein binds to ABCG8 protein]

NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912

G

aldo-keto reductase family 1, member C3

increases metabolic processing
increases reduction
multiple interactions

AKR1C3 protein results in increased metabolism of Androstenedione
AKR1C3 protein results in increased reduction of Androstenedione
[AKR1C3 protein results in increased metabolism of Androstenedione] which results in increased chemical synthesis of Dihydrotestosterone; [AKR1C3 protein results in increased metabolism of Androstenedione] which results in increased chemical synthesis of Testosterone; [AKR1C3 protein results in increased reduction of Androstenedione] which results in increased chemical synthesis of Testosterone; Indomethacin analog inhibits the reaction [AKR1C3 protein results in increased reduction of Androstenedione]; Indomethacin inhibits the reaction [AKR1C3 protein results in increased reduction of Androstenedione]; N-(4-chlorobenzoyl)melatonin inhibits the reaction [AKR1C3 protein results in increased reduction of Androstenedione]

PMID:17950253 PMID:19010312 PMID:20036328

NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873

G

aldo-keto reductase family 1, member D1

increases reduction
multiple interactions

AKR1D1 protein results in increased reduction of Androstenedione
[AKR1D1 protein alternative form results in increased reduction of Androstenedione] which results in increased chemical synthesis of androstane-3,17-dione; [AKR1D1 protein alternative form results in increased reduction of Androstenedione] which results in increased chemical synthesis of Etiocholanolone; [AKR1D1 protein results in increased reduction of Androstenedione] which results in increased chemical synthesis of androstane-3,17-dione; [AKR1D1 protein results in increased reduction of Androstenedione] which results in increased chemical synthesis of Etiocholanolone
AKR1D1 protein alternative form results in increased reduction of Androstenedione; AKR1D1 protein results in increased reduction of Androstenedione

NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372

G

androgen receptor

affects binding
multiple interactions

Androstenedione binds to AR protein
Androstenedione binds to and results in increased activity of AR protein
Androstenedione binds to and affects the activity of AR protein; Androstenedione binds to and results in increased activity of AR protein; Androstenedione inhibits the reaction [[Dihydrotestosterone binds to and results in increased activity of AR protein] which results in increased expression of KLK3 protein]; NCOA2 protein promotes the reaction [Androstenedione binds to and results in increased activity of AR protein]
AR mutant form inhibits the reaction [Androstenedione results in increased expression of NR5A2 mRNA]

PMID:12730620 PMID:14565775 PMID:15336702 PMID:17804755 PMID:19833195 More...

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

glycoprotein hormones, alpha polypeptide

increases secretion
multiple interactions

CGA protein results in increased secretion of Androstenedione
LEP protein inhibits the reaction [CGA protein results in increased secretion of Androstenedione]; Sodium Glutamate inhibits the reaction [CGA protein results in increased secretion of Androstenedione]

NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191

G

CREB binding protein

increases activity

Androstenedione results in increased activity of CREBBP protein

NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888

G

cytochrome P450, family 11, subfamily a, polypeptide 1

multiple interactions
increases expression

[Diethylstilbestrol results in decreased expression of CYP11A1 protein] which results in decreased abundance of Androstenedione; bicalutamide inhibits the reaction [Androstenedione results in increased expression of CYP11A1 protein]; Finasteride promotes the reaction [Androstenedione results in increased expression of CYP11A1 mRNA]; formestane promotes the reaction [Androstenedione results in increased expression of CYP11A1 mRNA]

PMID:21273442 PMID:23873838

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases expression
affects chemical synthesis
multiple interactions
affects abundance

Androstenedione results in decreased expression of CYP17A1 mRNA
CYP17A1 protein affects the chemical synthesis of Androstenedione
[CYP17A1 gene SNP affects the susceptibility to perfluorooctane sulfonic acid] which affects the abundance of Androstenedione; [CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione]; TNF protein inhibits the reaction [CYP17A1 protein affects the chemical synthesis of Androstenedione]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxyprogesterone] which results in increased chemical synthesis of Androstenedione]
CYP17A1 protein affects the abundance of Androstenedione

PMID:14522586 PMID:15555913 PMID:15562394 PMID:15625562 PMID:16030167 More...

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

affects metabolic processing
increases metabolic processing
decreases expression
multiple interactions
increases expression

CYP19A1 protein affects the metabolism of Androstenedione
CYP19A1 protein results in increased metabolism of Androstenedione
Androstenedione results in decreased expression of CYP19A1 mRNA
[Androstenedione results in decreased expression of CYP19A1 mRNA] which results in decreased abundance of Estradiol; bicalutamide inhibits the reaction [Androstenedione results in increased expression of CYP19A1 protein]; Finasteride promotes the reaction [Androstenedione results in increased expression of CYP19A1 mRNA]; formestane promotes the reaction [Androstenedione results in increased expression of CYP19A1 mRNA]
2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [CYP19A1 protein results in increased metabolism of Androstenedione]; [Fluconazole results in decreased activity of CYP19A1 protein] which results in decreased metabolism of Androstenedione; [Ketoconazole results in increased activity of CYP19A1 protein] which results in increased metabolism of Androstenedione; Atrazine promotes the reaction [CYP19A1 protein results in increased metabolism of Androstenedione]; bisphenol A affects the reaction [CYP19A1 protein results in increased metabolism of Androstenedione]; CYP19A1 protein binds to and results in increased metabolism of Androstenedione; Methoxychlor affects the reaction [CYP19A1 protein results in increased metabolism of Androstenedione]; Methyltestosterone inhibits the reaction [CYP19A1 protein affects the metabolism of Androstenedione]; Nandrolone inhibits the reaction [CYP19A1 protein affects the metabolism of Androstenedione]; Testosterone inhibits the reaction [CYP19A1 protein affects the metabolism of Androstenedione]; TNF protein promotes the reaction [CYP19A1 protein affects the metabolism of Androstenedione]; trestolone inhibits the reaction [CYP19A1 protein affects the metabolism of Androstenedione]; tributyltin inhibits the reaction [CYP19A1 protein binds to and results in increased metabolism of Androstenedione]

PMID:11522339 PMID:12628686 PMID:16030167 PMID:16033851 PMID:16054388 More...

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression
decreases expression

Androstenedione results in increased expression of CYP2B10 mRNA
Androstenedione results in decreased expression of CYP2B10 mRNA

PMID:7771797 PMID:11075820

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

Androstenedione promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

dehydrogenase/reductase 11

increases reduction

DHRS11 protein results in increased reduction of Androstenedione

NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295

G

dehydrogenase/reductase 3

increases metabolic processing

DHRS3 protein results in increased metabolism of Androstenedione

NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417

G

dehydrogenase/reductase 7

increases reduction

DHRS7 protein results in increased reduction of Androstenedione

NCBI chr 6:91,332,259...91,347,856
Ensembl chr 6:91,251,323...91,347,892

G

estrogen receptor 1

multiple interactions

Androstenedione binds to and results in increased activity of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions

Androstenedione binds to and results in increased activity of ESR2 protein

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

Fas ligand

decreases expression

Androstenedione results in decreased expression of FASLG mRNA

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

glutathione S-transferase alpha 1

increases chemical synthesis

GSTA1 protein results in increased chemical synthesis of Androstenedione

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

glutathione S-transferase alpha 2

decreases metabolic processing

GSTA2 protein polymorphism results in decreased metabolism of Androstenedione

NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798

G

hydroxysteroid (17-beta) dehydrogenase 12

increases metabolic processing

HSD17B12 protein results in increased metabolism of Androstenedione

NCBI chr 3:79,990,048...80,113,556
Ensembl chr 3:79,990,056...80,113,617

G

hydroxysteroid (17-beta) dehydrogenase 2

increases chemical synthesis

HSD17B2 protein results in increased chemical synthesis of Androstenedione

NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202

G

hydroxysteroid (17-beta) dehydrogenase 3

increases metabolic processing

HSD17B3 protein results in increased metabolism of Androstenedione

NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

increases chemical synthesis

HSD3B1 protein results in increased chemical synthesis of Androstenedione

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

kallikrein 1-related peptidase C10

multiple interactions

Androstenedione inhibits the reaction [[Dihydrotestosterone binds to and results in increased activity of AR protein] which results in increased expression of KLK3 protein]

NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052

G

leptin

multiple interactions

LEP protein inhibits the reaction [CGA protein results in increased secretion of Androstenedione]

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

luteinizing hormone subunit beta

increases abundance

LHB protein results in increased abundance of Androstenedione

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

mechanistic target of rapamycin kinase

multiple interactions
affects activity

[letrozole co-treated with Everolimus] inhibits the reaction [Androstenedione affects the activity of MTOR protein]; Everolimus inhibits the reaction [Androstenedione affects the activity of MTOR protein]; letrozole inhibits the reaction [Androstenedione affects the activity of MTOR protein]

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

nuclear receptor coactivator 1

multiple interactions

1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Androstenedione inhibits the reaction [NR1I3 protein binds to NCOA1 protein]]; Androstenedione inhibits the reaction [NR1I3 protein binds to NCOA1 protein]; isopimpinellin inhibits the reaction [Androstenedione inhibits the reaction [NR1I3 protein binds to NCOA1 protein]]

NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664

G

nuclear receptor coactivator 2

multiple interactions

NCOA2 protein promotes the reaction [Androstenedione binds to and results in increased activity of AR protein]

NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451

G

nuclear receptor coactivator 3

increases activity

Androstenedione results in increased activity of NCOA3 protein

NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594

G

nitric oxide synthase 2

increases expression

Androstenedione results in increased expression of NOS2 mRNA

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

Androstenedione binds to and results in increased activity of NR1I2 protein
Androstenedione binds to and affects the activity of NR1I2 protein

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions
decreases activity

1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Androstenedione inhibits the reaction [NR1I3 protein binds to NCOA1 protein]]; 1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Androstenedione results in decreased activity of NR1I3 protein]; Androstenedione inhibits the reaction [NR1I3 protein binds to NCOA1 protein]; isopimpinellin inhibits the reaction [Androstenedione inhibits the reaction [NR1I3 protein binds to NCOA1 protein]]; isopimpinellin inhibits the reaction [Androstenedione results in decreased activity of NR1I3 protein]

PMID:11075820 PMID:18692084

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

nuclear receptor subfamily 5, group A, member 2

increases expression
multiple interactions

Androstenedione results in increased expression of NR5A2 mRNA
AR mutant form inhibits the reaction [Androstenedione results in increased expression of NR5A2 mRNA]

NCBI chr13:48,313,634...48,433,494
Ensembl chr13:48,316,301...48,433,326

G

cytochrome p450 oxidoreductase

increases activity

Androstenedione results in increased activity of POR protein

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

G

peroxisome proliferator-activated receptor gamma

multiple interactions

Androstenedione binds to and results in decreased activity of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

receptor for activated C kinase 1

increases expression

Androstenedione results in increased expression of RACK1 mRNA; Androstenedione results in increased expression of RACK1 protein

NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975

G

signal transducer and activator of transcription 5B

increases activity

Androstenedione results in increased activity of STAT5B protein

NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668

G

thyroid hormone receptor beta

multiple interactions

Androstenedione binds to and results in increased activity of THRB protein

NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916

G

tumor necrosis factor

multiple interactions

TNF protein inhibits the reaction [CYP17A1 protein affects the chemical synthesis of Androstenedione]; TNF protein promotes the reaction [CYP19A1 protein affects the metabolism of Androstenedione]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

androst-5-ene-3,17-dione

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutathione S-transferase alpha 1

affects metabolic processing
increases metabolic processing

GSTA1 protein affects the metabolism of 5-androstene-3,17-dione
GSTA1 protein results in increased metabolism of 5-androstene-3,17-dione

PMID:11152686 PMID:16280386

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

androstane-3,17-dione

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldo-keto reductase family 1, member D1

increases chemical synthesis
multiple interactions
increases metabolic processing

AKR1D1 protein alternative form results in increased chemical synthesis of androstane-3,17-dione; AKR1D1 protein results in increased chemical synthesis of androstane-3,17-dione
[AKR1D1 protein alternative form results in increased metabolism of androstane-3,17-dione] which results in increased chemical synthesis of Etiocholanolone; [AKR1D1 protein alternative form results in increased reduction of Androstenedione] which results in increased chemical synthesis of androstane-3,17-dione; [AKR1D1 protein results in increased metabolism of androstane-3,17-dione] which results in increased chemical synthesis of Etiocholanolone; [AKR1D1 protein results in increased reduction of Androstenedione] which results in increased chemical synthesis of androstane-3,17-dione
AKR1D1 protein alternative form results in increased metabolism of androstane-3,17-dione; AKR1D1 protein results in increased metabolism of androstane-3,17-dione

NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372

G

dehydrogenase/reductase 11

increases reduction

DHRS11 protein results in increased reduction of androstane-3,17-dione

NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295

androsterone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

androgen receptor

affects binding

Androsterone binds to AR protein

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

cytochrome P450, family 17, subfamily a, polypeptide 1

affects chemical synthesis

CYP17A1 protein affects the chemical synthesis of Androsterone

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

dehydrogenase/reductase 11

increases reduction

DHRS11 protein results in increased reduction of Androsterone

NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295

G

glucose-6-phosphate dehydrogenase

decreases activity

Androsterone results in decreased activity of G6PD protein

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

hydroxysteroid (17-beta) dehydrogenase 12

increases metabolic processing

HSD17B12 protein results in increased metabolism of Androsterone

NCBI chr 3:79,990,048...80,113,556
Ensembl chr 3:79,990,056...80,113,617

G

solute carrier family 22 member 2

multiple interactions

Androsterone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

UDP glucuronosyltransferase family 1 member A1

multiple interactions

Androsterone inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Diethylstilbestrol]

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 1 family, polypeptide A2

multiple interactions

Androsterone inhibits the reaction [[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Androsterone inhibits the reaction [UGT1A3 protein results in increased glucuronidation of Hymecromone]

NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A5

increases glucuronidation

UGT1A4 protein SNP results in increased glucuronidation of Androsterone analog

NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glycosyltransferase 2 family, polypeptide B

increases glucuronidation

UGT2B protein results in increased glucuronidation of Androsterone

NCBI chr14:20,630,572...20,665,062
Ensembl chr14:20,630,250...20,651,776

G

UDP glucuronosyltransferase 2 family, polypeptide B1

increases metabolic processing

UGT2B17 protein results in increased metabolism of Androsterone

NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986

G

UDP glucuronosyltransferase family 2 member B7

increases glucuronidation
decreases activity
multiple interactions

UGT2B7 protein results in increased glucuronidation of Androsterone
Androsterone results in decreased activity of UGT2B7 protein
Androsterone inhibits the reaction [[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Androsterone inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Diethylstilbestrol]; Androsterone inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Hymecromone]

PMID:11186130 PMID:23126256 PMID:26875642 PMID:33290829

NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604

androsterone 3-glucosiduronic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Klotho

multiple interactions

androsterone glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]

NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080

dehydroepiandrosterone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily G member 5

multiple interactions

Dehydroepiandrosterone results in increased activity of [ABCG5 protein binds to ABCG8 protein]

NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563

G

ATP binding cassette subfamily G member 8

multiple interactions

Dehydroepiandrosterone results in increased activity of [ABCG5 protein binds to ABCG8 protein]

NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912

G

acyl-CoA oxidase 1

increases expression
multiple interactions

Dehydroepiandrosterone results in increased expression of ACOX1 mRNA
Dehydroepiandrosterone results in increased expression of ACOX1 mRNA; Dehydroepiandrosterone results in increased expression of ACOX1 protein
Dehydroepiandrosterone promotes the reaction [[ACOX1 protein results in increased metabolism of Palmitoyl Coenzyme A] which results in increased chemical synthesis of Hydrogen Peroxide]

PMID:10497882 PMID:16940010

NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232

G

acyl-CoA synthetase long-chain family member 1

increases expression

Dehydroepiandrosterone results in increased expression of ACSL1 mRNA

NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541

G

adrenoceptor beta 3

increases expression

Dehydroepiandrosterone results in increased expression of ADRB3 mRNA

NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552

G

anterior gradient 2, protein disulphide isomerase family member

affects expression

Dehydroepiandrosterone affects the expression of AGR2 mRNA

NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371

G

aldo-keto reductase family 1, member C3

affects metabolic processing

AKR1C18 protein affects the metabolism of Dehydroepiandrosterone

NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873

G

androgen receptor

multiple interactions
increases response to substance
affects binding

[AR protein mutant form results in increased susceptibility to Dehydroepiandrosterone] which results in increased activity of AR protein mutant form; [bicalutamide binds to and results in decreased activity of AR protein] inhibits the reaction [Dehydroepiandrosterone results in decreased expression of CYP1A2 mRNA]; AR protein affects the reaction [Dehydroepiandrosterone results in increased expression of RACK1 mRNA]; AR protein affects the reaction [Dehydroepiandrosterone results in increased expression of RACK1 protein]; Dehydroepiandrosterone binds to and results in decreased activity of AR protein; Dehydroepiandrosterone inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Dehydroepiandrosterone promotes the reaction [AR protein binds to MIR21 promoter]
Dehydroepiandrosterone binds to AR protein

PMID:14565775 PMID:15994348 PMID:23603339 PMID:25969534 PMID:27239218 More...

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

BCL2-associated agonist of cell death

increases expression

Dehydroepiandrosterone results in increased expression of BAD mRNA

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2 associated X, apoptosis regulator

increases expression

Dehydroepiandrosterone results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions
decreases expression
increases expression

Dexamethasone inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2 protein]; Dihydrotestosterone inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2 protein]; Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2 protein]
Dehydroepiandrosterone results in decreased expression of BCL2 protein

PMID:16407456 PMID:21062263

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

increases expression
multiple interactions

Dehydroepiandrosterone results in increased expression of BCL2L1 protein
Dexamethasone inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2L1 protein]; Dihydrotestosterone inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2L1 protein]; Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone results in increased expression of BCL2L1 protein]

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

catalase

increases activity

Dehydroepiandrosterone results in increased activity of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cell division cycle 20

decreases expression

Dehydroepiandrosterone results in decreased expression of CDC20 mRNA

NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512

G

cyclin-dependent kinase inhibitor 1A

increases expression

Dehydroepiandrosterone results in increased expression of CDKN1A mRNA
Dehydroepiandrosterone results in increased expression of CDKN1A protein

PMID:15752352 PMID:16457693

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 2A

increases expression

Dehydroepiandrosterone results in increased expression of CDKN2A protein

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

cAMP responsive element binding protein 1

affects phosphorylation

dehydroepiandrosterone affects phosphorylation of Crebbp protein in heart

RGD

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

cytochrome b-245 alpha chain

multiple interactions
increases expression

Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of CYBA protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of CYBA mRNA]; Quercetin affects the reaction [Dehydroepiandrosterone results in increased expression of CYBA protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of CYBA mRNA]
Dehydroepiandrosterone results in increased expression of CYBA mRNA; Dehydroepiandrosterone results in increased expression of CYBA protein

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

cytochrome P450, family 17, subfamily a, polypeptide 1

affects chemical synthesis
multiple interactions
affects metabolic processing
decreases expression

CYP17A1 protein affects the chemical synthesis of Dehydroepiandrosterone
[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone; Duloxetine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone]; Venlafaxine Hydrochloride inhibits the reaction [[CYP17A1 protein results in increased metabolism of 17-alpha-Hydroxypregnenolone] which results in increased chemical synthesis of Dehydroepiandrosterone]
CYP17A1 protein affects the metabolism of Dehydroepiandrosterone
Dehydroepiandrosterone results in decreased expression of CYP17A1 mRNA

PMID:15261307 PMID:15562394 PMID:15625562 PMID:15666818 PMID:15934942 More...

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

increases metabolic processing
multiple interactions
decreases activity

CYP19A1 protein results in increased metabolism of Dehydroepiandrosterone
Lipopolysaccharides inhibits the reaction [Dehydroepiandrosterone results in decreased activity of CYP19A1 protein]

PMID:10657851 PMID:16397352

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases degradation
decreases stability

Dehydroepiandrosterone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased activity of CYP1A1 protein]; Dehydroepiandrosterone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]; Dehydroepiandrosterone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Dehydroepiandrosterone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Dehydroepiandrosterone results in increased degradation of CYP1A1 mRNA
Dehydroepiandrosterone results in decreased stability of CYP1A1 mRNA

PMID:10575002 PMID:11597580

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
increases degradation
decreases expression

[bicalutamide binds to and results in decreased activity of AR protein] inhibits the reaction [Dehydroepiandrosterone results in decreased expression of CYP1A2 mRNA]; bicalutamide inhibits the reaction [Dehydroepiandrosterone results in increased degradation of CYP1A2 mRNA]; Dehydroepiandrosterone inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions
increases expression

Dehydroepiandrosterone inhibits the reaction [benz(a)anthracene promotes the reaction [CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]]; Dehydroepiandrosterone inhibits the reaction [benz(a)anthracene results in increased expression of CYP1B1 mRNA]; Dehydroepiandrosterone inhibits the reaction [CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]; Dehydroepiandrosterone inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]]
Dehydroepiandrosterone results in increased expression of CYP1B1 mRNA

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
increases hydroxylation

Dehydroepiandrosterone promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]
CYP3A4 protein results in increased hydroxylation of Dehydroepiandrosterone

PMID:15845858 PMID:19299527

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

increases expression

Dehydroepiandrosterone results in increased expression of CYP3A23-3A1 mRNA

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases hydroxylation

CYP3A5 protein results in increased hydroxylation of Dehydroepiandrosterone

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

cytochrome P450, family 4, subfamily a, polypeptide 1

multiple interactions
increases expression

Okadaic Acid inhibits the reaction [Dehydroepiandrosterone results in increased expression of CYP4A1 mRNA]

PMID:8700121 PMID:18079279

NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464

G

cytochrome P450, family 4, subfamily a, polypeptide 3

increases expression

Dehydroepiandrosterone results in increased expression of CYP4A3 mRNA

PMID:8700121 PMID:16940010

NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463

G

cytochrome P450 family 7 subfamily B member 1

increases hydroxylation

CYP7B1 protein results in increased hydroxylation of Dehydroepiandrosterone

NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698

G

drebrin-like

decreases expression

Dehydroepiandrosterone results in decreased expression of DBNL mRNA

NCBI chr14:80,666,115...80,681,155
Ensembl chr14:80,666,124...80,681,155

G

24-dehydrocholesterol reductase

affects expression

Dehydroepiandrosterone affects the expression of DHCR24 mRNA

NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137

G

dehydrogenase/reductase 11

increases reduction

DHRS11 protein results in increased reduction of Dehydroepiandrosterone

NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295

G

epidermal growth factor receptor

multiple interactions

EGFR protein promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

increases expression

Dehydroepiandrosterone results in increased expression of EHHADH mRNA

NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188

G

erythropoietin

multiple interactions

[Dehydroepiandrosterone co-treated with Testosterone co-treated with GH1] results in decreased expression of EPO protein

NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946

G

estrogen receptor 1

multiple interactions
increases phosphorylation
increases expression
affects binding

Dehydroepiandrosterone binds to and results in increased activity of ESR1 protein; ESR1 protein alternative form promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; GPER1 protein promotes the reaction [Dehydroepiandrosterone results in increased expression of ESR1 mRNA alternative form]
Dehydroepiandrosterone results in increased phosphorylation of ESR1 protein
Dehydroepiandrosterone results in increased expression of ESR1 mRNA alternative form; Dehydroepiandrosterone results in increased expression of ESR1 protein alternative form
Dehydroepiandrosterone binds to ESR1 protein

PMID:15994348 PMID:19913605 PMID:25969534 PMID:33049310

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions
affects binding

Dehydroepiandrosterone binds to and results in increased activity of ESR2 protein
Dehydroepiandrosterone binds to Esr2 protein

CTD
RGD

PMID:15994348 PMID:33049310 PMID:9048584

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Dehydroepiandrosterone promotes the reaction [FOS protein binds to MIR21 promoter]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

glucose-6-phosphatase catalytic subunit 1

decreases expression

Dehydroepiandrosterone results in decreased expression of G6PC1 mRNA

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

glucose-6-phosphate dehydrogenase

multiple interactions

Dehydroepiandrosterone inhibits the reaction [ascorbate-2-phosphate results in increased activity of G6PD protein]

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

growth hormone 1

multiple interactions

[Dehydroepiandrosterone co-treated with Testosterone co-treated with GH1] results in decreased expression of EPO protein

NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078

G

glycerol-3-phosphate dehydrogenase 1

multiple interactions
increases activity

benz(a)anthracene inhibits the reaction [Dehydroepiandrosterone results in increased activity of GPD1 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Dehydroepiandrosterone results in increased activity of GPD1 protein]

NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529

G

G protein-coupled estrogen receptor 1

multiple interactions
increases expression

4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Dehydroepiandrosterone results in increased expression of GPER1 mRNA]; GPER1 protein promotes the reaction [Dehydroepiandrosterone results in increased expression of ESR1 mRNA alternative form]; GPER1 protein promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]
Dehydroepiandrosterone results in increased expression of GPER1 mRNA; Dehydroepiandrosterone results in increased expression of GPER1 protein

NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

increases expression

Dehydroepiandrosterone results in increased expression of HADHB mRNA

NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions

Dehydroepiandrosterone inhibits the reaction [25-hydroxycholesterol results in decreased activity of HMGCR protein]; Dehydroepiandrosterone inhibits the reaction [27-hydroxycholesterol results in decreased activity of HMGCR protein]

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

hydroxysteroid (17-beta) dehydrogenase 1

affects metabolic processing
increases chemical synthesis

HSD17B1 protein affects the metabolism of Dehydroepiandrosterone
HSD17B1 protein results in increased chemical synthesis of Dehydroepiandrosterone

NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927

G

hydroxysteroid (17-beta) dehydrogenase 12

increases metabolic processing

HSD17B12 protein results in increased metabolism of Dehydroepiandrosterone

NCBI chr 3:79,990,048...80,113,556
Ensembl chr 3:79,990,056...80,113,617

G

hydroxysteroid (17-beta) dehydrogenase 2

affects metabolic processing
increases chemical synthesis

HSD17B2 protein affects the metabolism of Dehydroepiandrosterone
HSD17B2 protein results in increased chemical synthesis of Dehydroepiandrosterone

NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202

G

hydroxysteroid (17-beta) dehydrogenase 4

affects metabolic processing
increases chemical synthesis

HSD17B4 protein affects the metabolism of Dehydroepiandrosterone
HSD17B4 protein results in increased chemical synthesis of Dehydroepiandrosterone

NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

affects metabolic processing

HSD3B1 protein affects the metabolism of Dehydroepiandrosterone

PMID:15261307 PMID:16054388

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

insulin-like growth factor binding protein 3

decreases secretion

Dehydroepiandrosterone results in decreased secretion of IGFBP3 protein

NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083

G

interleukin 1 beta

increases expression
multiple interactions

Dehydroepiandrosterone results in increased expression of IL1B protein
Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of IL1B protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

increases expression
multiple interactions

Dehydroepiandrosterone results in increased expression of IL6 protein
Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of IL6 protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

multiple interactions
increases expression
decreases expression

Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of INS1 protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of INS1 protein]
Dehydroepiandrosterone results in decreased expression of INS1 protein

PMID:12659879 PMID:27634381

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

insulin receptor substrate 1

multiple interactions
decreases phosphorylation

Metformin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein]

NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

Dehydroepiandrosterone promotes the reaction [JUN protein binds to MIR21 promoter]
Dehydroepiandrosterone results in increased expression of JUN protein

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

Klotho

multiple interactions

Dehydroepiandrosterone analog inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]

NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080

G

kallikrein 1-related peptidase C10

increases expression
multiple interactions

Dehydroepiandrosterone results in increased expression of KLK3 mRNA; Dehydroepiandrosterone results in increased expression of KLK3 protein
bicalutamide inhibits the reaction [Dehydroepiandrosterone results in increased expression of KLK3 mRNA]; bicalutamide inhibits the reaction [Dehydroepiandrosterone results in increased expression of KLK3 protein]; Fulvestrant inhibits the reaction [Dehydroepiandrosterone results in increased expression of KLK3 mRNA]; Fulvestrant inhibits the reaction [Dehydroepiandrosterone results in increased expression of KLK3 protein]

NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052

G

leptin

decreases expression

Dehydroepiandrosterone results in decreased expression of LEP protein

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

mitogen-activated protein kinase 6

decreases expression

Dehydroepiandrosterone results in decreased expression of MAPK6 mRNA

NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:76,146,690...76,169,720

G

microRNA 200a

multiple interactions

[Pertussis Toxin co-treated with Dehydroepiandrosterone] results in increased expression of MIR200A mRNA; [wortmannin co-treated with Dehydroepiandrosterone] results in increased expression of MIR200A mRNA

NCBI chr 5:166,648,494...166,648,582

G

microRNA 21

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; AG 1879 inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; bicalutamide inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; Dactinomycin inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; Dehydroepiandrosterone promotes the reaction [AR protein binds to MIR21 promoter]; Dehydroepiandrosterone promotes the reaction [FOS protein binds to MIR21 promoter]; Dehydroepiandrosterone promotes the reaction [JUN protein binds to MIR21 promoter]; EGFR protein promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; ESR1 protein alternative form promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; GPER1 protein promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; methyl-beta-cyclodextrin inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; RTKI cpd inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; Wortmannin inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

G

microRNA 22

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR22 mRNA]; [Dactinomycin co-treated with Dehydroepiandrosterone] results in increased expression of MIR22 mRNA; [Dehydroepiandrosterone results in increased expression of MIR22 mRNA] which results in decreased expression of PDCD4 protein; [wortmannin co-treated with Dehydroepiandrosterone] results in increased expression of MIR22 mRNA; Dactinomycin promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR22 mRNA]

NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,307,039...60,307,133

G

microRNA let-7d

increases expression

Dehydroepiandrosterone results in increased expression of MIRLET7D mRNA

NCBI chr17:16,115,893...16,115,990
Ensembl chr17:16,115,893...16,115,990

G

mitochondrially encoded cytochrome c oxidase I

increases expression

Dehydroepiandrosterone results in increased expression of COX1 mRNA

NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867

G

mitochondrially encoded cytochrome c oxidase III

increases expression

Dehydroepiandrosterone results in increased expression of COX3 mRNA

NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382

G

natriuretic peptide B

decreases expression

Dehydroepiandrosterone results in decreased expression of NPPB mRNA

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

Dehydroepiandrosterone binds to and results in increased activity of NR1I2 protein

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 3, group C, member 1

increases expression
multiple interactions

Dehydroepiandrosterone results in increased expression of NR3C1 protein
Flutamide inhibits the reaction [Dehydroepiandrosterone results in increased expression of NR3C1 protein]

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

neurotensin

affects expression

Dehydroepiandrosterone affects the expression of NTS mRNA

NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423

G

oxidized low density lipoprotein receptor 1

increases expression
multiple interactions

Dehydroepiandrosterone results in increased expression of OLR1 mRNA; Dehydroepiandrosterone results in increased expression of OLR1 protein
Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of OLR1 protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of OLR1 mRNA]; Quercetin affects the reaction [Dehydroepiandrosterone results in increased expression of OLR1 protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of OLR1 mRNA]

NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523

G

orosomucoid 1

decreases expression

Dehydroepiandrosterone results in decreased expression of ORM1 mRNA

NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154

G

programmed cell death 4

decreases expression
multiple interactions

Dehydroepiandrosterone results in decreased expression of PDCD4 mRNA; Dehydroepiandrosterone results in decreased expression of PDCD4 protein
[Dehydroepiandrosterone results in increased expression of MIR22 mRNA] which results in decreased expression of PDCD4 protein

NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275

G

phospholipase C, gamma 2

increases expression

Dehydroepiandrosterone results in increased expression of PLCG2 mRNA

NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930

G

peroxisome proliferator activated receptor alpha

increases activity
multiple interactions
increases expression
decreases phosphorylation

Dehydroepiandrosterone results in increased activity of PPARA protein
[Dehydroepiandrosterone results in increased expression of PPP2CA mRNA] which results in decreased phosphorylation of PPARA protein; Okadaic Acid inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of PPARA protein]; Okadaic Acid inhibits the reaction [Dehydroepiandrosterone results in increased activity of PPARA protein]
Dehydroepiandrosterone results in increased expression of PPARA mRNA; Dehydroepiandrosterone results in increased expression of PPARA protein

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

PPARG coactivator 1 alpha

increases expression

Dehydroepiandrosterone results in increased expression of PPARGC1A mRNA
dehydroepiandrosterone increases expression of Ppargc1a protein in heart

CTD
RGD

PMID:12659879 PMID:22523357

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

protein phosphatase 2 catalytic subunit alpha

multiple interactions
increases expression

[Dehydroepiandrosterone results in increased expression of PPP2CA mRNA] which results in decreased phosphorylation of PPARA protein

NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862

G

prolactin

increases secretion

PRL protein results in increased secretion of Dehydroepiandrosterone

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

proteasome activator subunit 1

decreases expression

Dehydroepiandrosterone results in decreased expression of PSME1 mRNA

NCBI chr15:29,069,012...29,071,888
Ensembl chr15:29,068,729...29,071,890

G

RAB38, member RAS oncogene family

decreases expression

Dehydroepiandrosterone results in decreased expression of RAB38 mRNA

NCBI chr 1:142,182,566...142,262,923
Ensembl chr 1:142,182,556...142,262,924

G

receptor for activated C kinase 1

increases expression
multiple interactions

Dehydroepiandrosterone results in increased expression of RACK1 mRNA; Dehydroepiandrosterone results in increased expression of RACK1 protein
AR protein affects the reaction [Dehydroepiandrosterone results in increased expression of RACK1 mRNA]; AR protein affects the reaction [Dehydroepiandrosterone results in increased expression of RACK1 protein]; Flutamide inhibits the reaction [Dehydroepiandrosterone results in increased expression of RACK1 mRNA]; Flutamide inhibits the reaction [Dehydroepiandrosterone results in increased expression of RACK1 protein]

PMID:27239218 PMID:28412309

NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975

G

RB transcriptional corepressor 1

increases expression
multiple interactions

Dehydroepiandrosterone results in increased expression of RB1 mRNA
Dehydroepiandrosterone results in decreased expression of and results in decreased phosphorylation of RB1 protein

PMID:15752352 PMID:16940010

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
affects localization

Metformin inhibits the reaction [Dehydroepiandrosterone affects the localization of RELA protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone affects the localization of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

arginyl aminopeptidase

decreases expression

Dehydroepiandrosterone results in decreased expression of RNPEP mRNA

NCBI chr13:46,699,458...46,717,829
Ensembl chr13:46,699,463...46,717,998

G

ribosomal protein L41

decreases expression

Dehydroepiandrosterone results in decreased expression of RPL41 mRNA

NCBI chr 7:977,885...978,965

G

sirtuin 1

decreases expression
affects expression

Dehydroepiandrosterone results in decreased expression of SIRT1 protein
Dehydroepiandrosterone affects the expression of SIRT1 protein

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

solute carrier family 22 member 8

multiple interactions

Dehydroepiandrosterone inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]

NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450

G

superoxide dismutase 2

decreases expression

Dehydroepiandrosterone results in decreased expression of SOD2 mRNA

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

SRC proto-oncogene, non-receptor tyrosine kinase

increases phosphorylation
multiple interactions

Dehydroepiandrosterone results in increased phosphorylation of SRC protein
4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Dehydroepiandrosterone results in increased phosphorylation of SRC protein]
Dihydrotestosterone inhibits the reaction [Dehydroepiandrosterone results in increased phosphorylation of SRC protein]; Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone results in increased phosphorylation of SRC protein]

PMID:16407456 PMID:25969534

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

steroid 5 alpha-reductase 1

affects metabolic processing

SRD5A1 protein affects the metabolism of Dehydroepiandrosterone

NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461

G

steroid sulfatase

increases chemical synthesis

STS protein results in increased chemical synthesis of Dehydroepiandrosterone

NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402

G

sulfotransferase family 1E member 1

increases sulfation

SULT1E1 protein results in increased sulfation of Dehydroepiandrosterone

NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275

G

sulfotransferase family 2A member 1

multiple interactions
increases metabolic processing
increases sulfation

2,3'-dichlorobiphenyl metabolite inhibits the reaction [Dehydroepiandrosterone results in increased expression of SULT2A1 protein]; 2,3'-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 2,3-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 2,4'-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 2,5-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein affects the metabolism of Dehydroepiandrosterone]; 2,5-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 3',4'-dihydroxy-4-monochlorobiphenyl inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 3,3'-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 3,5-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; 4-chlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; Benzoquinones analog affects the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; Benzoquinones analog inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; Dehydroepiandrosterone inhibits the reaction [Benzoquinones analog inhibits the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT2A1 protein]]; Ethanol inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]; Polychlorinated Biphenyls inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]
SULT2A1 protein results in increased metabolism of Dehydroepiandrosterone

PMID:10623578 PMID:10752640 PMID:14570759 PMID:17112228 PMID:19646966 More...

NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134

G

sulfotransferase family 2B member 1

increases sulfation

SULT2B1 protein results in increased sulfation of Dehydroepiandrosterone

NCBI chr 1:96,200,155...96,261,295
Ensembl chr 1:96,200,156...96,261,295

G

toll-like receptor 4

multiple interactions
increases expression

Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of TLR4 protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of TLR4 mRNA]; Quercetin affects the reaction [Dehydroepiandrosterone results in increased expression of TLR4 protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of TLR4 mRNA]
Dehydroepiandrosterone results in increased expression of TLR4 mRNA; Dehydroepiandrosterone results in increased expression of TLR4 protein

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

increases expression
multiple interactions

Dehydroepiandrosterone results in increased expression of TNF protein
[Lipopolysaccharides co-treated with Dehydroepiandrosterone] results in increased secretion of TNF protein; Flutamide inhibits the reaction [[Lipopolysaccharides co-treated with Dehydroepiandrosterone] results in increased secretion of TNF protein]
Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of TNF protein]; Quercetin inhibits the reaction [Dehydroepiandrosterone results in increased expression of TNF protein]

PMID:27239218 PMID:27634381

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

DNA topoisomerase II beta

decreases expression

Dehydroepiandrosterone results in decreased expression of TOP2B mRNA

NCBI chr15:9,051,340...9,111,721
Ensembl chr15:9,051,341...9,112,085

G

tumor protein p53

increases expression

Dehydroepiandrosterone results in increased expression of TP53 mRNA

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

thioredoxin interacting protein

decreases expression

Dehydroepiandrosterone results in decreased expression of TXNIP protein

NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886

G

uncoupling protein 1

increases expression
decreases expression

Dehydroepiandrosterone results in increased expression of UCP1 mRNA; Dehydroepiandrosterone results in increased expression of UCP1 protein
Dehydroepiandrosterone results in decreased expression of UCP1 mRNA

NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852

G

uncoupling protein 2

decreases expression

Dehydroepiandrosterone results in decreased expression of UCP2 mRNA

NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611

G

uncoupling protein 3

increases expression
decreases expression

Dehydroepiandrosterone results in increased expression of UCP3 mRNA
Dehydroepiandrosterone results in decreased expression of UCP3 mRNA

NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762

G

vacuole membrane protein 1

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]; AG 1879 inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]; Dactinomycin inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]; methyl-beta-cyclodextrin inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]; Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]

NCBI chr10:71,405,058...71,505,045
Ensembl chr10:71,405,452...71,505,007

G

xanthine dehydrogenase

decreases activity

Dehydroepiandrosterone results in decreased activity of XDH protein

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

dehydroepiandrosterone sulfate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases activity
multiple interactions

Dehydroepiandrosterone Sulfate results in decreased activity of ABCB11 protein
Dehydroepiandrosterone Sulfate inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

acyl-CoA oxidase 1

increases expression
multiple interactions

Dehydroepiandrosterone Sulfate results in increased expression of ACOX1 mRNA
PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of ACOX1 mRNA]

NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232

G

BCL2, apoptosis regulator

increases expression
multiple interactions

Dehydroepiandrosterone Sulfate results in increased expression of BCL2 protein
Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone Sulfate results in increased expression of BCL2 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

increases expression
multiple interactions

Dehydroepiandrosterone Sulfate results in increased expression of BCL2L1 protein
Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone Sulfate results in increased expression of BCL2L1 protein]

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

carnitine palmitoyltransferase 1A

multiple interactions
increases expression

[Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CPT1A protein
Dehydroepiandrosterone Sulfate results in increased expression of CPT1A protein

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

cytochrome P450, subfamily 2, polypeptide 11

multiple interactions

[Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP2C11 protein

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions

[Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP2C6 protein
CYP2C19 gene SNP affects the reaction [1-naphthol affects the abundance of Dehydroepiandrosterone Sulfate]

PMID:25786523 PMID:33771511

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions

CYP2D6 gene SNP affects the reaction [1-naphthol affects the abundance of Dehydroepiandrosterone Sulfate]

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
affects metabolic processing

[Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP3A2 protein
CYP3A4 protein affects the metabolism of Dehydroepiandrosterone Sulfate

PMID:2271712 PMID:25786523

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 4, subfamily a, polypeptide 1

increases expression
multiple interactions

Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 mRNA; Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 protein
[Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP4A1 protein

PMID:8700121 PMID:25786523

NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464

G

cytochrome P450, family 4, subfamily a, polypeptide 3

increases expression

Dehydroepiandrosterone Sulfate results in increased expression of CYP4A3 mRNA

NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463

G

enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

increases expression
multiple interactions

Dehydroepiandrosterone Sulfate results in increased expression of EHHADH mRNA
PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of EHHADH mRNA]

NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188

G

fatty acid binding protein 1

increases expression
multiple interactions

Dehydroepiandrosterone Sulfate results in increased expression of FABP1 mRNA
PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of FABP1 mRNA]

NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

[Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased expression of FOS protein

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

interleukin 1 beta

multiple interactions
increases abundance

Dexamethasone inhibits the reaction [IL1B protein results in increased abundance of Dehydroepiandrosterone Sulfate]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

mitogen activated protein kinase 1

multiple interactions

[Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

N-acetyltransferase 1

multiple interactions

Dehydroepiandrosterone Sulfate inhibits the reaction [NAT1 protein results in increased acetylation of 4-Aminobenzoic Acid]; Dehydroepiandrosterone Sulfate promotes the reaction [NAT1 protein results in increased acetylation of 4-Aminobenzoic Acid]

NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520

G

proopiomelanocortin

increases abundance

POMC results in increased abundance of Dehydroepiandrosterone Sulfate

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

peroxisome proliferator activated receptor alpha

multiple interactions
increases response to substance

PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of ACOX1 mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of CYP4A1 mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of CYP4A3 mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of EHHADH mRNA]; PPARA protein affects the reaction [Dehydroepiandrosterone Sulfate results in increased expression of FABP1 mRNA]
PPARA protein results in increased susceptibility to Dehydroepiandrosterone Sulfate

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

prolactin

increases abundance

PRL protein results in increased abundance of Dehydroepiandrosterone Sulfate

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

sirtuin 1

increases expression

Dehydroepiandrosterone Sulfate results in increased expression of SIRT1 protein

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

sirtuin 6

increases expression

Dehydroepiandrosterone Sulfate results in increased expression of SIRT6 protein

NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914

G

solute carrier family 10 member 6

increases transport

SLC10A6 protein results in increased transport of Dehydroepiandrosterone Sulfate

NCBI chr14:6,080,716...6,102,902
Ensembl chr14:6,080,717...6,103,037

G

solute carrier family 22 member 12

multiple interactions

Potassium promotes the reaction [SLC22A12 protein results in increased uptake of Dehydroepiandrosterone Sulfate]

NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555

G

solute carrier family 22, member 19

affects transport

SLC22A19 protein affects the transport of Dehydroepiandrosterone Sulfate

NCBI chr 1:204,910,450...204,965,538
Ensembl chr 1:204,910,455...204,965,538

G

solute carrier family 22, member 25

increases uptake
multiple interactions

SLC22A9 protein results in increased uptake of Dehydroepiandrosterone Sulfate
Dehydroepiandrosterone Sulfate inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]

PMID:17132213 PMID:18441515

NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085

G

solute carrier family 22 member 7

increases transport

SLC22A7 protein results in increased transport of Dehydroepiandrosterone Sulfate

NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921

G

solute carrier family 22 member 8

affects transport
increases uptake

SLC22A8 protein affects the transport of Dehydroepiandrosterone Sulfate
SLC22A8 protein results in increased uptake of Dehydroepiandrosterone Sulfate

PMID:11306713 PMID:16098483 PMID:17255469

NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450

G

solute carrier organic anion transporter family member 1B2

multiple interactions

Dehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B3 protein results in increased susceptibility to cyanoginosin LR]; Dehydroepiandrosterone Sulfate inhibits the reaction [SLCO1B3 protein results in increased susceptibility to Okadaic Acid]

NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981

G

SRC proto-oncogene, non-receptor tyrosine kinase

increases phosphorylation

Dehydroepiandrosterone Sulfate results in increased phosphorylation of SRC protein

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

steroid sulfatase

affects metabolic processing

STS protein affects the metabolism of Dehydroepiandrosterone Sulfate

NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402

equilenin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

steroid sulfatase

increases metabolic processing

STS protein results in increased metabolism of Equilenin

NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402

equilin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adiponectin, C1Q and collagen domain containing

multiple interactions

Equilin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein]

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

androgen receptor

affects localization
multiple interactions

Equilin affects the localization of AR protein
Equilin binds to and results in increased activity of AR protein; Equilin inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]

PMID:28478275 PMID:33049310

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

estrogen receptor 1

increases activity
affects binding
multiple interactions

Equilin results in increased activity of ESR1 protein
Equilin binds to ESR1 protein
Equilin binds to and results in increased activity of ESR1 protein; Fulvestrant inhibits the reaction [Equilin results in increased activity of ESR1 protein]

PMID:11750080 PMID:12504345 PMID:21138273 PMID:22562034 PMID:33049310

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions

Equilin binds to and results in increased activity of ESR2 protein

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

fatty acid binding protein 4

multiple interactions

Equilin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein]

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

glutathione S-transferase pi 1

multiple interactions

Equilin inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

insulin 2

multiple interactions

Equilin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein]; Equilin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein]

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

Equilin binds to and results in decreased activity of NR1I2 protein
Equilin binds to and results in increased activity of NR1I2 protein

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

peroxisome proliferator-activated receptor gamma

multiple interactions

Equilin binds to and results in decreased activity of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

retinoid X receptor alpha

affects binding

Equilin binds to RXRA protein

NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712

G

trefoil factor 1

increases expression
multiple interactions

Equilin results in increased expression of TFF1 mRNA
fulvestrant inhibits the reaction [Equilin results in increased expression of TFF1 mRNA]

NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597

G

thyroid hormone receptor alpha

multiple interactions

Equilin binds to and results in increased activity of THRA protein

NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936

G

utrophin

increases expression

Equilin results in increased expression of UTRN mRNA

NCBI chr 1:6,720,854...7,224,313
Ensembl chr 1:6,722,594...7,224,313

estrone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions
increases expression
decreases expression
increases export

Elacridar inhibits the reaction [ABCB1 protein results in increased export of Estrone]
Estrone results in increased expression of ABCB1 mRNA; Estrone results in increased expression of ABCB1 protein
Estrone results in decreased expression of ABCB1 protein

PMID:15290871 PMID:16925584

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 8

increases response to substance

ABCC8 protein results in increased susceptibility to Estrone

NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510

G

ATP binding cassette subfamily G member 2

increases expression

Estrone results in increased expression of ABCG2 mRNA

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

abhydrolase domain containing 2, acylglycerol lipase

increases expression

Estrone results in increased expression of ABHD2 mRNA

NCBI chr 1:133,217,403...133,298,564
Ensembl chr 1:133,217,375...133,299,061

G

alpha-fetoprotein

affects binding

Estrone binds to AFP protein

PMID:23013281 PMID:25349334

NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480

G

aldo-keto reductase family 1, member C3

increases metabolic processing
increases reduction
multiple interactions

AKR1C3 protein results in increased metabolism of Estrone
AKR1C3 protein results in increased reduction of Estrone
[AKR1C3 protein results in increased metabolism of Estrone] which results in increased chemical synthesis of Estradiol; [AKR1C3 protein results in increased reduction of Estrone] which results in increased chemical synthesis of Estradiol

PMID:19010312 PMID:20036328

NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873

G

AKT serine/threonine kinase 1

increases phosphorylation
multiple interactions

Estrone results in increased phosphorylation of AKT1 protein
wortmannin inhibits the reaction [Estrone results in increased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aminolevulinate dehydratase

decreases expression

Estrone results in decreased expression of ALAD mRNA

NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474

G

alkaline phosphatase, placental

increases chemical synthesis

ALPP protein results in increased chemical synthesis of Estrone

NCBI chr 9:87,765,846...87,768,606
Ensembl chr 9:87,765,860...87,768,606

G

androgen receptor

multiple interactions

Estrone binds to and results in increased activity of AR protein; Estrone inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]

PMID:12676605 PMID:33049310

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

amphiregulin

increases expression

Estrone results in increased expression of AREG mRNA

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

Rho GDP dissociation inhibitor alpha

decreases expression

Estrone results in decreased expression of ARHGDIA mRNA

NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023

G

carbonic anhydrase 12

increases expression

Estrone results in increased expression of CA12 mRNA

NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440

G

caspase 3

multiple interactions
increases activity

Palmitic Acid promotes the reaction [Estrone results in increased activity of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

increases activity
multiple interactions

Estrone results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Estrone results in increased activity of CASP7 protein]

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

cyclin G2

decreases expression

Estrone results in decreased expression of CCNG2 mRNA

NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830

G

catechol-O-methyltransferase

increases methylation

COMT protein results in increased methylation of Estrone metabolite

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

C-X-C motif chemokine ligand 12

increases expression

Estrone results in increased expression of CXCL12 mRNA

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

cytochrome P450, family 17, subfamily a, polypeptide 1

affects abundance

CYP17A1 protein affects the abundance of Estrone

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

affects chemical synthesis
multiple interactions
increases chemical synthesis

CYP19A1 protein affects the chemical synthesis of Estrone
[Fluconazole results in decreased activity of CYP19A1 protein] which results in decreased chemical synthesis of Estrone; [Ketoconazole results in increased activity of CYP19A1 protein] which results in increased chemical synthesis of Estrone; Estrone analog binds to and results in decreased activity of CYP19A1 protein; TNF protein promotes the reaction [CYP19A1 protein affects the chemical synthesis of Estrone]
CYP19A1 protein results in increased chemical synthesis of Estrone

PMID:16030167 PMID:16039845 PMID:16054388 PMID:31330226

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases hydroxylation
affects binding
multiple interactions

CYP1A1 protein polymorphism results in increased hydroxylation of Estrone
CYP1A1 protein binds to Estrone
Estrone promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]

PMID:12093619 PMID:15805301 PMID:27966929

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
affects binding

CYP1A2 protein promotes the reaction [Estrone binds to Deoxyguanosine]
CYP1A2 protein binds to Estrone

PMID:21907773 PMID:27966929

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases hydroxylation
affects binding
multiple interactions
affects hydroxylation

CYP1B1 protein results in increased hydroxylation of Estrone
CYP1B1 protein binds to Estrone
Estrone binds to and results in decreased activity of CYP1B1 protein
CYP1B1 protein polymorphism affects the hydroxylation of Estrone

PMID:15763594 PMID:16207128 PMID:19563207 PMID:27966929

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression

Estrone results in increased expression of CYP2B10 mRNA

PMID:7771797 PMID:11075820 PMID:12948398

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
affects binding

CYP3A4 protein promotes the reaction [Estrone binds to Deoxyguanosine]; Estrone inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]
CYP3A4 protein binds to Estrone

PMID:19299527 PMID:21907773 PMID:27966929

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

dehydrogenase/reductase 11

increases reduction

DHRS11 protein results in increased reduction of Estrone

NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295

G

dehydrogenase/reductase 3

increases metabolic processing

DHRS3 protein results in increased metabolism of Estrone

NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417

G

dehydrogenase/reductase 7

increases reduction

DHRS7 protein results in increased reduction of Estrone

NCBI chr 6:91,332,259...91,347,856
Ensembl chr 6:91,251,323...91,347,892

G

deleted in malignant brain tumors 1

increases expression
multiple interactions

Estrone results in increased expression of DMBT1 mRNA
fulvestrant inhibits the reaction [Estrone results in increased expression of DMBT1 mRNA]

NCBI chr 1:185,617,469...185,696,476
Ensembl chr 1:185,617,294...185,696,478

G

ephrin A1

decreases expression

Estrone results in decreased expression of EFNA1 mRNA

NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866

G

epidermal growth factor receptor

multiple interactions

Estrone inhibits the reaction [LEPR gene mutant form inhibits the reaction [EGFR protein results in increased phosphorylation of EGFR protein]]; Estrone inhibits the reaction [LEPR gene mutant form results in decreased expression of EGFR mRNA]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

early growth response 3

increases expression

Estrone results in increased expression of EGR3 mRNA

PMID:15159206 PMID:26865669

NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627

G

enolase 2

decreases expression

Estrone results in decreased expression of ENO2 mRNA

NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980

G

Eph receptor A4

decreases expression

Estrone results in decreased expression of EPHA4 mRNA

NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139

G

estrogen receptor 1

multiple interactions
increases expression
affects binding
increases activity

Estrone binds to and results in increased activity of ESR1 protein; Estrone inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; Estrone inhibits the reaction [ESR1 results in increased susceptibility to Cisplatin]; Estrone inhibits the reaction [Estradiol binds to ESR1 protein]; Estrone promotes the reaction [ESR1 protein alternative form binds to ESR1 protein alternative form]; Estrone promotes the reaction [ESR1 protein binds to ESR1 protein]; Estrone promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form]; Estrone promotes the reaction [ESR1 protein modified form binds to NRIP1 protein modified form]; Fulvestrant inhibits the reaction [Estrone results in increased activity of ESR1 protein]
Estrone results in increased expression of ESR1 mRNA
Estrone binds to ESR1 protein

PMID:9048584 PMID:11162928 PMID:11331656 PMID:11518614 PMID:11750080 More...

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions
affects binding
affects localization
increases activity

Estrone inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein]; Estrone inhibits the reaction [Estradiol binds to ESR2 protein alternative form]; Estrone inhibits the reaction [Estradiol binds to ESR2 protein]
Estrone binds to Esr2 protein
Estrone binds to and results in increased activity of ESR2 protein
Estrone binds to ESR2 protein
Estrone affects the localization of ESR2 protein
Estrone results in increased activity of ESR2 protein

CTD
RGD

PMID:8650195 PMID:9048584 PMID:9492041 PMID:11518614 PMID:19913605 More...

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

four and a half LIM domains 2

increases expression

Estrone results in increased expression of FHL2 mRNA

NCBI chr 9:45,388,979...45,462,421
Ensembl chr 9:45,388,981...45,431,192

G

forkhead box C1

increases expression

Estrone results in increased expression of FOXC1 mRNA

NCBI chr17:32,631,379...32,635,361
Ensembl chr17:32,633,142...32,634,803

G

hydroxysteroid (17-beta) dehydrogenase 1

affects metabolic processing
multiple interactions
increases chemical synthesis

HSD17B1 protein affects the metabolism of Estrone
[HSD17B1 protein co-treated with NADP] results in increased reduction of Estrone; coumarin analog inhibits the reaction [[HSD17B1 protein co-treated with NADP] results in increased reduction of Estrone]
HSD17B1 protein results in increased chemical synthesis of Estrone

PMID:16054388 PMID:21232530

NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927

G

hydroxysteroid (17-beta) dehydrogenase 12

increases metabolic processing

HSD17B12 protein results in increased metabolism of Estrone

PMID:16166196 PMID:17641292

NCBI chr 3:79,990,048...80,113,556
Ensembl chr 3:79,990,056...80,113,617

G

hydroxysteroid (17-beta) dehydrogenase 2

increases chemical synthesis
affects metabolic processing

HSD17B2 protein results in increased chemical synthesis of Estrone
HSD17B2 protein affects the metabolism of Estrone

NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202

G

hydroxysteroid (17-beta) dehydrogenase 4

increases chemical synthesis
affects metabolic processing

HSD17B4 protein results in increased chemical synthesis of Estrone
HSD17B4 protein affects the metabolism of Estrone

NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952

G

hydroxysteroid (17-beta) dehydrogenase 7

affects metabolic processing
increases chemical synthesis

HSD17B7 protein affects the metabolism of Estrone
HSD17B7 protein results in increased chemical synthesis of Estrone

NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017

G

intercellular adhesion molecule 1

decreases expression

Estrone results in decreased expression of ICAM1 mRNA

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

inhibitor of DNA binding 3

decreases expression

Estrone results in decreased expression of ID3 mRNA

NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349

G

insulin-like growth factor 2

increases chemical synthesis

IGF2 protein results in increased chemical synthesis of Estrone

NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018

G

interleukin 6

multiple interactions

Estrone promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

integrin subunit alpha M

decreases expression
multiple interactions

Estrone results in decreased expression of ITGAM protein
Estrone inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAM protein]

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

integrin subunit alpha X

decreases expression
multiple interactions

Estrone results in decreased expression of ITGAX protein
Estrone inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAX protein]

NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698

G

Janus kinase 2

increases expression

Estrone results in increased expression of JAK2 mRNA

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

kynureninase

decreases expression

Estrone results in decreased expression of KYNU mRNA

NCBI chr 3:27,778,646...27,929,470
Ensembl chr 3:27,778,772...27,929,488

G

leptin receptor

multiple interactions

Estrone inhibits the reaction [LEPR gene mutant form inhibits the reaction [EGFR protein results in increased phosphorylation of EGFR protein]]; Estrone inhibits the reaction [LEPR gene mutant form results in decreased expression of EGFR mRNA]

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

G

mitogen activated protein kinase 1

increases phosphorylation
affects phosphorylation
multiple interactions

Estrone results in increased phosphorylation of MAPK1 protein
Estrone affects the phosphorylation of MAPK1 protein
4,4,',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakis(benzene-1,3-disulfonate) inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]; 4-ethylphenol analog affects the reaction [Estrone affects the phosphorylation of MAPK1 protein]; 4-nonylphenol analog affects the reaction [Estrone affects the phosphorylation of MAPK1 protein]; 4-octylphenol analog affects the reaction [Estrone affects the phosphorylation of MAPK1 protein]; 4-propylphenol affects the reaction [Estrone affects the phosphorylation of MAPK1 protein]; bisphenol A affects the reaction [Estrone affects the phosphorylation of MAPK1 protein]; NF023 inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]; Nystatin inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]; Pertussis Toxin inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]
4-ethylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]; 4-nonylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]; 4-octylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]; 4-propylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]; bisphenol A inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]

PMID:20870566 PMID:20950447 PMID:21767602 PMID:22230296

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation
affects phosphorylation
multiple interactions

Estrone results in increased phosphorylation of MAPK3 protein
Estrone affects the phosphorylation of MAPK3 protein
4,4,',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakis(benzene-1,3-disulfonate) inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]; 4-ethylphenol analog affects the reaction [Estrone affects the phosphorylation of MAPK3 protein]; 4-nonylphenol analog affects the reaction [Estrone affects the phosphorylation of MAPK3 protein]; 4-octylphenol analog affects the reaction [Estrone affects the phosphorylation of MAPK3 protein]; 4-propylphenol affects the reaction [Estrone affects the phosphorylation of MAPK3 protein]; bisphenol A affects the reaction [Estrone affects the phosphorylation of MAPK3 protein]; NF023 inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]; Nystatin inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]; Pertussis Toxin inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]
4-ethylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]; 4-nonylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]; 4-octylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]; 4-propylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]; bisphenol A inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]

PMID:20870566 PMID:20950447 PMID:21767602 PMID:22230296

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

microtubule associated monooxygenase, calponin and LIM domain containing 2

increases expression

Estrone results in increased expression of MICAL2 mRNA

NCBI chr 1:166,345,853...166,530,575
Ensembl chr 1:166,345,859...166,471,719
Ensembl chr 1:166,345,859...166,471,719

G

MYB proto-oncogene, transcription factor

increases expression

Estrone results in increased expression of MYB mRNA

NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057

G

MYB proto-oncogene like 1

increases expression

Estrone results in increased expression of MYBL1 mRNA

NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183

G

nuclear receptor coactivator 1

multiple interactions

Estrone promotes the reaction [NR1I3 protein binds to NCOA1 protein]
Estrone promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form]

PMID:23015691 PMID:23383871

NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664

G

nuclear receptor coactivator 3

increases expression

Estrone results in increased expression of NCOA3 mRNA; Estrone results in increased expression of NCOA3 protein

NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594

G

nicotinamide riboside kinase 1

increases expression

Estrone results in increased expression of NMRK1 mRNA

NCBI chr 1:216,049,350...216,076,792
Ensembl chr 1:216,049,437...216,076,791

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

Estrone binds to and results in increased activity of NR1I2 protein

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

increases expression
increases activity
affects binding
multiple interactions
affects localization

Estrone results in increased expression of NR1I3 mRNA
Estrone results in increased activity of NR1I3 protein
Estrone binds to NR1I3 protein
Estrone inhibits the reaction [KN 62 results in decreased activity of NR1I3 protein]
Estrone binds to and results in increased activity of NR1I3 protein; Estrone inhibits the reaction [KN 62 results in decreased activity of NR1I3 protein]; Estrone inhibits the reaction [Progesterone results in decreased activity of NR1I3 protein]; Estrone promotes the reaction [NR1I3 protein binds to NCOA1 protein]
Estrone affects the localization of NR1I3 mRNA

PMID:11075820 PMID:12948398 PMID:16929008 PMID:23015691 PMID:28927721

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

nuclear receptor interacting protein 1

multiple interactions

Estrone promotes the reaction [ESR1 protein modified form binds to NRIP1 protein modified form]

NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761

G

olfactomedin 1

increases expression

Estrone results in increased expression of OLFM1 mRNA

NCBI chr 3:11,520,522...11,558,240
Ensembl chr 3:11,520,729...11,558,239

G

platelet derived growth factor subunit A

decreases expression

Estrone results in decreased expression of PDGFA mRNA

NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497

G

PDZ domain containing 1

increases expression

Estrone results in increased expression of PDZK1 mRNA

PMID:15159206 PMID:26865669

NCBI chr 2:184,376,161...184,407,514
Ensembl chr 2:184,376,161...184,407,514

G

progesterone receptor

decreases expression
increases expression
multiple interactions

Estrone results in decreased expression of PGR mRNA alternative form; Estrone results in decreased expression of PGR protein alternative form
Estrone results in increased expression of PGR mRNA
fulvestrant inhibits the reaction [Estrone results in decreased expression of PGR protein alternative form]

PMID:15806153 PMID:26865669

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

phosphoinositide-3-kinase regulatory subunit 3

decreases expression

Estrone results in decreased expression of PIK3R3 mRNA

NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583

G

prolactin

increases expression
increases secretion
multiple interactions

Estrone results in increased expression of PRL protein
Estrone results in increased secretion of PRL protein
4-ethylphenol inhibits the reaction [Estrone results in increased secretion of PRL protein]; 4-nonylphenol inhibits the reaction [Estrone results in increased secretion of PRL protein]; 4-octylphenol affects the reaction [Estrone results in increased secretion of PRL protein]; 4-propylphenol affects the reaction [Estrone results in increased secretion of PRL protein]; bisphenol A inhibits the reaction [Estrone results in increased secretion of PRL protein]

PMID:3780563 PMID:20950447

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

serine protease 23

increases expression

Estrone results in increased expression of PRSS23 mRNA

NCBI chr 1:143,402,725...143,422,182
Ensembl chr 1:143,401,396...143,422,091

G

Rap guanine nucleotide exchange factor like 1

increases expression

Estrone results in increased expression of RAPGEFL1 mRNA

NCBI chr10:83,793,711...83,810,373
Ensembl chr10:83,793,694...83,810,371

G

RB binding protein 8, endonuclease

increases expression

Estrone results in increased expression of RBBP8 mRNA

NCBI chr18:2,922,985...2,988,851
Ensembl chr18:2,921,286...2,988,846

G

RNA terminal phosphate cyclase-like 1

increases expression

Estrone results in increased expression of RCL1 mRNA

NCBI chr 1:226,824,561...226,869,046
Ensembl chr 1:226,824,534...226,902,315

G

ret proto-oncogene

increases expression

Estrone results in increased expression of RET mRNA

NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176

G

rhomboid 5 homolog 1

decreases expression

Estrone results in decreased expression of RHBDF1 mRNA

NCBI chr10:15,406,832...15,419,765
Ensembl chr10:15,406,859...15,419,763

G

selenium binding protein 1

decreases expression

Estrone results in decreased expression of SELENBP1 mRNA

NCBI chr 2:182,494,004...182,504,594
Ensembl chr 2:182,493,978...182,504,594

G

selectin P

increases expression

Estrone results in increased expression of SELP mRNA

NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845

G

serum/glucocorticoid regulated kinase 1

increases expression

Estrone results in increased expression of SGK1 mRNA

NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283

G

serum/glucocorticoid regulated kinase family, member 3

increases expression

Estrone results in increased expression of SGK3 mRNA

NCBI chr 5:9,345,761...9,472,243
Ensembl chr 5:9,346,040...9,415,476

G

sex hormone binding globulin

affects binding

Estrone binds to SHBG protein

NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057

G

siah E3 ubiquitin protein ligase 2

increases expression

Estrone results in increased expression of SIAH2 mRNA

NCBI chr 2:142,913,924...142,931,752
Ensembl chr 2:142,914,003...142,931,950

G

solute carrier family 12 member 2

decreases expression

Estrone results in decreased expression of SLC12A2 mRNA

NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440

G

solute carrier family 18 member A2

multiple interactions

Estrone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC18A2 protein]

NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325

G

solute carrier family 22 member 2

multiple interactions

Estrone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 6 member 3

multiple interactions

Estrone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased activity of SLC6A3 protein]

NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413

G

solute carrier family 7 member 11

increases expression

Estrone results in increased expression of SLC7A11 mRNA

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

solute carrier family 7 member 5

increases expression

Estrone results in increased expression of SLC7A5 mRNA

NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823

G

spermine oxidase

increases expression

Estrone results in increased expression of SMOX mRNA

NCBI chr 3:118,731,814...118,767,242
Ensembl chr 3:118,731,900...118,765,710
Ensembl chr X:118,731,900...118,765,710

G

steroid sulfatase

increases chemical synthesis

STS protein results in increased chemical synthesis of Estrone

NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402

G

sulfotransferase family 1A member 1

increases metabolic processing

SULT1A1 protein results in increased metabolism of Estrone

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

sulfotransferase family 1E member 1

multiple interactions
increases sulfation
decreases activity
affects sulfation

[Estrone co-treated with SULT1E1 protein] results in decreased sulfation of Ethinyl Estradiol
SULT1E1 protein results in increased sulfation of Estrone
Estrone results in decreased activity of SULT1E1 protein
Estrone affects the sulfation of SULT1E1 protein

PMID:8185618 PMID:11358677 PMID:15483196 PMID:16914110

NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275

G

sulfotransferase family 2A member 1

increases metabolic processing

SULT2A1 protein results in increased metabolism of Estrone

NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134

G

sulfotransferase family 4A, member 1

increases metabolic processing

SULT4A1 protein results in increased metabolism of Estrone

NCBI chr 7:115,216,066...115,240,156
Ensembl chr 7:115,216,066...115,240,085

G

supervillin

increases expression

Estrone results in increased expression of SVIL mRNA

NCBI chr17:52,648,502...52,844,114
Ensembl chr17:52,648,502...52,793,404

G

transcription factor AP-2 gamma

increases expression

Estrone results in increased expression of TFAP2C mRNA

NCBI chr 3:161,315,114...161,322,998
Ensembl chr 3:161,315,031...161,322,995

G

trefoil factor 1

increases expression
multiple interactions

Estrone results in increased expression of TFF1 mRNA
fulvestrant inhibits the reaction [Estrone results in increased expression of TFF1 mRNA]

NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597

G

tissue factor pathway inhibitor

decreases expression

Estrone results in decreased expression of TFPI mRNA

NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880

G

thyroid hormone receptor beta

multiple interactions

Estrone binds to and results in increased activity of THRB protein

NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916

G

tumor necrosis factor

multiple interactions

TNF protein promotes the reaction [CYP19A1 protein affects the chemical synthesis of Estrone]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation

UGT1A1 protein results in increased glucuronidation of Estrone; UGT1A1 protein results in increased glucuronidation of Estrone analog

PMID:15117964 PMID:15472229

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases glucuronidation

UGT1A3 protein results in increased glucuronidation of Estrone; UGT1A3 protein results in increased glucuronidation of Estrone analog

PMID:15117964 PMID:15472229

NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of Estrone; UGT1A9 protein results in increased glucuronidation of Estrone analog

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 2 member B7

increases glucuronidation

UGT2B7 protein results in increased glucuronidation of Estrone; UGT2B7 protein results in increased glucuronidation of Estrone analog

NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604

G

vascular cell adhesion molecule 1

decreases expression

Estrone results in decreased expression of VCAM1 mRNA

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

tryptophanyl-tRNA synthetase 1

increases expression

Estrone results in increased expression of WARS1 mRNA

NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269

G

X-linked inhibitor of apoptosis

increases expression

Estrone results in increased expression of XIAP mRNA; Estrone results in increased expression of XIAP protein

NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700

estrone 3-O-(beta-D-glucuronide)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Klotho

increases hydrolysis
multiple interactions

KL protein results in increased hydrolysis of estrone-3-glucuronide
estrone-3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]

NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080

estrone 3-sulfate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 8

affects transport

ABCA8 protein affects the transport of estrone sulfate

NCBI chr10:94,917,520...94,991,199
Ensembl chr10:94,917,520...94,990,988

G

ATP binding cassette subfamily C member 2

affects export
increases activity

ABCC2 protein affects the export of estrone sulfate
estrone sulfate results in increased activity of ABCC2 protein; estrone sulfate results in increased activity of ABCC2 protein modified form

PMID:15652233 PMID:15904671 PMID:16046661

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily G member 2

affects export
increases export
increases uptake
multiple interactions
affects transport

ABCG2 protein affects the export of estrone sulfate
ABCG2 protein results in increased export of estrone sulfate
ABCG2 protein results in increased uptake of estrone sulfate
[Adenosine Triphosphate co-treated with ABCG2 protein] results in increased uptake of estrone sulfate; Androstenedione inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate]; Estradiol inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate]; hippuric acid inhibits the reaction [ABCG2 protein results in increased export of estrone sulfate]; Indican inhibits the reaction [ABCG2 protein results in increased export of estrone sulfate]; Kynurenic Acid inhibits the reaction [ABCG2 protein results in increased export of estrone sulfate]; Progesterone inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate]; Risperidone inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate]; Sulfasalazine inhibits the reaction [[Adenosine Triphosphate co-treated with ABCG2 protein] results in increased uptake of estrone sulfate]; Testosterone inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate]
ABCG2 protein affects the transport of estrone sulfate

PMID:15901800 PMID:18834354 PMID:19505989 PMID:21483698 PMID:22581381 More...

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

dehydrogenase/reductase 11

increases reduction

DHRS11 protein results in increased reduction of estrone sulfate

NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295

G

estrogen receptor 2

affects binding

Estrone-3-sulfate binds to Esr2 protein

RGD

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

interleukin 1 alpha

decreases expression

estrone sulfate results in decreased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 6

decreases expression

estrone sulfate results in decreased expression of IL6 mRNA

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

platelet derived growth factor subunit A

decreases expression

estrone sulfate results in decreased expression of PDGFA mRNA

NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497

G

solute carrier family 10 member 1

multiple interactions

daidzein metabolite inhibits the reaction [SLC10A1 protein results in increased transport of estrone sulfate]; daidzein metabolite promotes the reaction [SLC10A1 protein results in increased transport of estrone sulfate]; estrone sulfate inhibits the reaction [SLC10A1 protein results in increased transport of daidzein metabolite]

NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670

G

solute carrier family 10 member 6

increases transport
increases uptake
increases response to substance
multiple interactions

SLC10A6 protein results in increased transport of estrone sulfate
SLC10A6 protein results in increased uptake of estrone sulfate
SLC10A6 protein results in increased susceptibility to estrone sulfate
daidzein inhibits the reaction [SLC10A6 protein results in increased transport of estrone sulfate]; daidzein metabolite inhibits the reaction [SLC10A6 protein results in increased transport of estrone sulfate]; estrone sulfate inhibits the reaction [SLC10A6 protein results in increased transport of daidzein metabolite]; Sodium promotes the reaction [SLC10A6 protein results in increased uptake of estrone sulfate]

PMID:23562556 PMID:25319728 PMID:30186172

NCBI chr14:6,080,716...6,102,902
Ensembl chr14:6,080,717...6,103,037

G

solute carrier family 17 member 3

affects transport

SLC17A3 gene SNP affects the transport of estrone sulfate

NCBI chr17:41,270,804...41,300,132
Ensembl chr17:41,270,812...41,295,256

G

solute carrier family 22 member 12

increases uptake

SLC22A12 protein results in increased uptake of estrone sulfate

NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555

G

solute carrier family 22, member 19

multiple interactions
affects transport

estrone sulfate inhibits the reaction [SLC22A19 protein results in increased uptake of ochratoxin A]
4-methylumbelliferyl sulfate inhibits the reaction [SLC22A19 protein affects the transport of estrone sulfate]; Bumetanide inhibits the reaction [SLC22A19 protein affects the transport of estrone sulfate]; Diclofenac inhibits the reaction [SLC22A19 protein affects the transport of estrone sulfate]; estradiol sulfate inhibits the reaction [SLC22A19 protein affects the transport of estrone sulfate]; Furosemide inhibits the reaction [SLC22A19 protein affects the transport of estrone sulfate]; Ibuprofen inhibits the reaction [SLC22A19 protein affects the transport of estrone sulfate]; Probenecid inhibits the reaction [SLC22A19 protein affects the transport of estrone sulfate]; Succinic Acid affects the reaction [SLC22A19 protein affects the transport of estrone sulfate]; Sulfobromophthalein inhibits the reaction [SLC22A19 protein affects the transport of estrone sulfate]

PMID:15068970 PMID:16079298

NCBI chr 1:204,910,450...204,965,538
Ensembl chr 1:204,910,455...204,965,538

G

solute carrier family 22 member 20

multiple interactions
increases uptake

2,4-Dichlorophenoxyacetic Acid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; Glutarates promotes the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; ochratoxin A inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; p-Aminohippuric Acid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; Penicillin G inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; Probenecid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; Salicylates inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]; Uric Acid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]

NCBI chr 1:203,257,374...203,273,854
Ensembl chr 1:203,257,374...203,273,822

G

solute carrier family 22, member 25

affects transport
increases import
multiple interactions
increases uptake

SLC22A9 protein affects the transport of estrone sulfate
SLC22A9 protein results in increased import of estrone sulfate
candesartan cilexetil inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; candesartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; Dehydroepiandrosterone Sulfate inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; losartan carboxylic acid inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; Losartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; pranlukast inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; Probenecid inhibits the reaction [SLC22A9 protein results in increased import of estrone sulfate]; Probenecid inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]; Tobacco Smoke Pollution inhibits the reaction [SLC22A9 protein results in increased import of estrone sulfate]; Valsartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]
4-methylumbelliferyl sulfate inhibits the reaction [SLC22A9 protein affects the transport of estrone sulfate]; Glutarates affects the reaction [SLC22A9 protein affects the transport of estrone sulfate]; naphthyl sulfate inhibits the reaction [SLC22A9 protein affects the transport of estrone sulfate]; Succinic Acid inhibits the reaction [SLC22A9 protein affects the transport of estrone sulfate]

PMID:16079298 PMID:17132213 PMID:18441515 PMID:28629854

NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085

G

solute carrier family 22 member 6

increases uptake

SLC22A6 protein results in increased uptake of estrone sulfate

NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173

G

solute carrier family 22 member 7

multiple interactions
increases uptake

Fumarates promotes the reaction [SLC22A7 protein results in increased uptake of estrone sulfate]; Succinates promotes the reaction [SLC22A7 protein results in increased uptake of estrone sulfate]

NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921

G

solute carrier family 22 member 8

multiple interactions
increases import
affects transport
increases uptake

5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; aristolochic acid I inhibits the reaction [SLC22A8 results in increased uptake of estrone sulfate]; bisphenol A inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; bisphenol F inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; bisphenol S inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Bumetanide inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Cefaclor inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Cefdinir inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; cefoselis inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Cefotiam inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Ceftibuten inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Ceftizoxime inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Cephaloridine inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Cholates inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Cimetidine inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; cyazofamid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Dehydroepiandrosterone inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Diclofenac inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; estrone sulfate inhibits the reaction [SLC22A8 protein results in increased uptake of Famotidine]; estrone sulfate promotes the reaction [SLC22A8 results in increased export of p-Aminohippuric Acid]; Famotidine inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Furosemide inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Ibuprofen inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Indomethacin inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Quercetin inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; rhein inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; rhein metabolite inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; tetrabromobisphenol A inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Tobacco Smoke Pollution inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]
SLC22A8 protein results in increased uptake of estrone sulfate; SLC22A8 results in increased uptake of estrone sulfate
3,4-dihydroxymandelic acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; 3,4-Dihydroxyphenylacetic Acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; 5-methoxyindoleacetic acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Bumetanide inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; estrone sulfate inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Furosemide inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; hexadecafluoro-nonanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]; Homovanillic Acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Indocyanine Green inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; methoxytryptophol inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Penicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; perfluoro-n-heptanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]; perfluorodecanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]; perfluorooctanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]; Piroxicam inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Sulfobromophthalein inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Vanilmandelic Acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]

PMID:10224140 PMID:11306713 PMID:15100168 PMID:15319347 PMID:15496291 More...

NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450

G

solute carrier organic anion transporter family, member 1a4

affects uptake
multiple interactions
increases uptake
increases transport
increases import

SLCO1A4 protein affects the uptake of estrone sulfate
7-hydroxymethotrexate inhibits the reaction [SLCO1A2 mRNA results in increased import of estrone sulfate]; artemisinin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Chloroquine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Mefloquine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Methotrexate inhibits the reaction [SLCO1A2 mRNA results in increased import of estrone sulfate]; naringin inhibits the reaction [SLCO1A2 protein alternative form results in increased uptake of estrone sulfate]; naringin inhibits the reaction [SLCO1A2 protein results in increased transport of estrone sulfate]; perfluorodecanoic acid inhibits the reaction [SLCO1A2 protein results in increased import of estrone sulfate]; Pyrimethamine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Quinine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]
SLCO1A2 protein alternative form results in increased uptake of estrone sulfate; SLCO1A2 protein results in increased uptake of estrone sulfate
SLCO1A2 mRNA results in increased import of estrone sulfate; SLCO1A2 protein results in increased import of estrone sulfate

PMID:16702441 PMID:20639259 PMID:21561886 PMID:25466967 PMID:27504015

NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573

G

solute carrier organic anion transporter family member 1B2

multiple interactions
increases uptake

cyazofamid inhibits the reaction [SLCO1B3 protein results in increased uptake of estrone sulfate]

PMID:32003934 PMID:34619012

NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981

G

solute carrier organic anion transporter family, member 2b1

increases import
multiple interactions
increases uptake

SLCO2B1 protein results in increased import of estrone sulfate; SLCO2B1 results in increased import of estrone sulfate
2,2',4,4',5,6'-hexabromodiphenyl ether inhibits the reaction [SLCO2B1 results in increased import of estrone sulfate]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [SLCO2B1 results in increased import of estrone sulfate]; [icariin results in decreased activity of SLCO2B1 protein] which results in decreased uptake of estrone sulfate; daidzein inhibits the reaction [SLCO2B1 protein results in increased transport of estrone sulfate]; daidzein metabolite inhibits the reaction [SLCO2B1 protein results in increased transport of estrone sulfate]; estrone sulfate inhibits the reaction [SLCO2B1 protein results in increased transport of daidzein metabolite]; estrone sulfate inhibits the reaction [SLCO2B1 protein results in increased uptake of Quercetin]; Mefloquine affects the reaction [SLCO2B1 protein results in increased uptake of estrone sulfate]; pentabromodiphenyl ether inhibits the reaction [SLCO2B1 results in increased import of estrone sulfate]; Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of estrone sulfate]; Sulfobromophthalein inhibits the reaction [SLCO2B1 protein results in increased import of estrone sulfate]; Tobacco Smoke Pollution inhibits the reaction [SLCO2B1 protein results in increased import of estrone sulfate]

PMID:16714376 PMID:20176623 PMID:24265111 PMID:24285294 PMID:24947867 More...

NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353

G

solute carrier organic anion transporter family, member 3a1

multiple interactions

estrone sulfate promotes the reaction [SLCO3A1 protein results in increased uptake of simvastatin acid]

NCBI chr 1:128,106,232...128,388,043
Ensembl chr 1:128,106,228...128,387,925

G

steroid sulfatase

affects metabolic processing
decreases sulfation

STS protein affects the metabolism of estrone sulfate
STS protein results in decreased sulfation of estrone sulfate

PMID:15597397 PMID:16054388

NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402

G

sulfotransferase family 1E member 1

multiple interactions

[[Oxygen deficiency co-treated with Oxygen] results in increased expression of SULT1E1 protein] which results in increased abundance of estrone sulfate

NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275

exemestane

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily G member 4

increases expression

exemestane results in increased expression of ABCG4 mRNA

NCBI chr 8:44,611,187...44,629,818
Ensembl chr 8:44,611,187...44,626,881

G

ADCYAP receptor type I

increases expression

exemestane results in increased expression of ADCYAP1R1 mRNA

NCBI chr 4:84,593,558...84,642,700
Ensembl chr 4:84,593,892...84,642,700

G

androgen receptor

multiple interactions
affects localization

exemestane binds to and results in increased activity of AR protein
exemestane affects the localization of AR protein

PMID:25752796 PMID:28478275

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

amphiregulin

increases expression

exemestane results in increased expression of AREG mRNA

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

CD83 molecule

increases expression

exemestane results in increased expression of CD83 mRNA

NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases activity

exemestane results in decreased activity of CYP19A1 protein

PMID:15837728 PMID:15909811 PMID:16034487 PMID:16054421 PMID:21341743 More...

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

DAB adaptor protein 2

increases expression

exemestane results in increased expression of DAB2 mRNA

NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476

G

dynein axonemal assembly factor 9

increases expression

exemestane results in increased expression of DNAAF9 mRNA

NCBI chr 3:117,918,047...118,052,641
Ensembl chr 3:117,921,620...118,052,630

G

EBF transcription factor 1

increases expression

exemestane results in increased expression of EBF1 mRNA

NCBI chr10:29,095,858...29,489,142
Ensembl chr10:29,099,933...29,487,665

G

estrogen receptor 1

multiple interactions

1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [exemestane binds to and results in increased activity of ESR1 protein]; exemestane binds to and results in increased activity of ESR1 protein; Fulvestrant inhibits the reaction [exemestane binds to and results in increased activity of ESR1 protein]

PMID:18677558 PMID:25752796

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

glypican 2

increases expression

exemestane results in increased expression of GPC2 mRNA

NCBI chr12:17,277,875...17,284,297
Ensembl chr12:17,277,875...17,284,208

G

homeobox D11

increases expression

exemestane results in increased expression of HOXD11 mRNA

NCBI chr 3:59,584,840...59,587,257
Ensembl chr 3:59,585,039...59,586,783

G

inositol polyphosphate-5-phosphatase K

increases expression

exemestane results in increased expression of INPP5K mRNA

NCBI chr10:60,474,262...60,495,813
Ensembl chr10:60,475,897...60,496,773

G

integrator complex subunit 4

increases expression

exemestane results in increased expression of INTS4 mRNA

NCBI chr 1:151,790,062...151,853,827
Ensembl chr 1:151,786,553...151,853,827

G

kinesin family member 13B

increases expression

exemestane results in increased expression of KIF13B mRNA

NCBI chr15:38,908,257...39,066,021
Ensembl chr15:38,924,624...39,084,879

G

kallikrein-related peptidase 7

increases expression

exemestane results in increased expression of KLK7 mRNA

NCBI chr 1:94,267,170...94,271,361
Ensembl chr 1:94,266,605...94,271,332

G

meteorin, glial cell differentiation regulator

increases expression

exemestane results in increased expression of METRN mRNA

NCBI chr10:14,816,684...14,818,702
Ensembl chr10:14,816,572...14,818,701

G

marker of proliferation Ki-67

decreases expression

exemestane results in decreased expression of MKI67 protein

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

MYB proto-oncogene like 2

increases expression

exemestane results in increased expression of MYBL2 mRNA

NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708

G

myosin IXb

increases expression

exemestane results in increased expression of MYO9B mRNA

NCBI chr16:17,945,379...18,030,114
Ensembl chr16:17,945,448...18,030,126

G

osteoclastogenesis associated transmembrane protein 1

increases expression

exemestane results in increased expression of OSTM1 mRNA

NCBI chr20:46,071,657...46,187,049
Ensembl chr20:46,153,075...46,187,023

G

progesterone receptor

decreases expression
increases expression

exemestane results in decreased expression of PGR protein
exemestane results in increased expression of PGR mRNA

PMID:15909811 PMID:16002280 PMID:18677558

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

phospholipase C, gamma 2

increases expression

exemestane results in increased expression of PLCG2 mRNA

NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930

G

ring finger protein 123

increases expression

exemestane results in increased expression of RNF123 mRNA

NCBI chr 8:108,740,176...108,768,177
Ensembl chr 8:108,739,620...108,767,675

G

ribosomal RNA processing 12

increases expression

exemestane results in increased expression of RRP12 mRNA

NCBI chr 1:240,672,378...240,705,992
Ensembl chr 1:240,672,382...240,706,018

G

solute carrier family 13 member 4

increases expression

exemestane results in increased expression of SLC13A4 mRNA

NCBI chr 4:63,943,369...63,988,852
Ensembl chr 4:63,943,395...63,988,857

G

solute carrier family 22 member 2

multiple interactions

exemestane inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

small integral membrane protein 43

increases expression

exemestane results in increased expression of SMIM43 mRNA

NCBI chr 2:119,380,454...119,385,966
Ensembl chr 2:119,385,754...119,385,945

G

TBC1 domain family, member 17

increases expression

exemestane results in increased expression of TBC1D17 mRNA

NCBI chr 1:95,324,770...95,333,156
Ensembl chr 1:95,322,737...95,333,005

G

trefoil factor 1

increases expression

exemestane results in increased expression of TFF1 mRNA

NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597

G

TNF receptor superfamily member 14

increases expression

exemestane results in increased expression of TNFRSF14 mRNA

NCBI chr 5:165,486,069...165,494,421
Ensembl chr 5:165,484,262...165,493,703

G

TRIO and F-actin binding protein

increases expression

exemestane results in increased expression of TRIOBP mRNA

NCBI chr 7:110,505,916...110,569,301
Ensembl chr 7:110,506,248...110,562,474

G

X inactive specific transcript

increases expression

exemestane results in increased expression of XIST mRNA

NCBI chr X:68,474,987...68,492,500

formestane

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

androgen receptor

multiple interactions
increases expression

formestane metabolite inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]
formestane analog results in increased expression of AR mRNA; formestane metabolite results in increased expression of AR mRNA; formestane results in increased expression of AR mRNA

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

cytochrome P450, family 11, subfamily a, polypeptide 1

multiple interactions

formestane promotes the reaction [Androstenedione results in increased expression of CYP11A1 mRNA]; formestane promotes the reaction [Testosterone results in increased expression of CYP11A1 mRNA]

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions
decreases activity

formestane inhibits the reaction [Atrazine results in increased activity of CYP19A1 protein]; formestane inhibits the reaction [CYP19A1 protein affects the chemical synthesis of 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine]; formestane inhibits the reaction [CYP19A1 protein affects the metabolism of Methadone]; formestane inhibits the reaction [propazine results in increased activity of CYP19A1 protein]; formestane inhibits the reaction [Simazine results in increased activity of CYP19A1 protein]
formestane inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of CYP19A1 protein]; formestane inhibits the reaction [FSHB protein results in increased activity of CYP19A1 protein]; formestane promotes the reaction [Androstenedione results in increased expression of CYP19A1 mRNA]; formestane promotes the reaction [Testosterone results in increased expression of CYP19A1 mRNA]
formestane results in decreased activity of CYP19A1 protein

PMID:10746939 PMID:10806373 PMID:15242824 PMID:15319488 PMID:16177243 More...

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

estrogen receptor 1

increases expression

formestane metabolite results in increased expression of ESR1 mRNA

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

follicle stimulating hormone subunit beta

multiple interactions

formestane inhibits the reaction [FSHB protein results in increased activity of CYP19A1 protein]

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

hydroxysteroid (17-beta) dehydrogenase 1

decreases activity

formestane results in decreased activity of HSD17B1 protein

NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19880
chemical entity	19878
group	19831
inorganic group	19410
oxo group	18914
organic oxo compound	18914
carbonyl compound	18914
ketone	17263
oxo steroid	10532
17-oxo steroid	268
(3beta,5alpha,7alpha)-3,7-dihydroxyandrostan-17-one	0
(5alpha)-androst-3-en-17-one	0
11beta-hydroxyandrost-4-ene-3,17-dione	0
15alpha-hydroxyestrone	0
16alpha-hydroxyandrost-4-ene-3,17-dione	0
16alpha-hydroxydehydroepiandrosterone	0
16alpha-hydroxydehydroepiandrosterone 3-sulfate	0
16alpha-hydroxyestrone +	0
16alpha-hydroxyestrone 16-O-(beta-D-glucuronide)	0
16alpha-hydroxyestrone 3-O-(beta-D-glucuronide)	0
16beta-hydroxyestrone	0
19-hydroxyandrost-4-ene-3,17-dione	0
19-norandrosterone	0
1alpha-hydroxyandrost-4-ene-3,17-dione	0
2-hydroxy-3-O-methyl estrone	0
2-hydroxyestrone 2-O-(beta-D-glucuronide)	0
2-hydroxyestrone 3-O-(beta-D-glucuronide)	0
2-methoxyestrone +	1
2-methoxyestrone 3-O-(beta-D-glucuronide)	0
3,17-dioxoandrost-4-en-19-al	0
3-(2-allyloxy)estra-1,3,5(10)-triene-16,17-dione 16-oxime	0
3alpha-hydroxy-5beta-androstan-17-one +	2
3beta-(2-diethylaminoethoxy)androst-5-en-17-one	0
3beta-hydroxy-5alpha-androstane-7,17-dione	0
4-hydroxyestrone +	5
4-hydroxyestrone 3-O-(beta-D-glucuronide)	0
4-hydroxyestrone 4-O-(beta-D-glucuronide)	0
4-methoxyestrone +	0
4-methoxyestrone 3-O-(beta-D-glucuronide)	0
5alpha-androst-1-ene-3,17-dione	0
5alpha-androstan-1,3,17-trione	0
6alpha-hydroxyestrone	0
6beta-hydroxyandrost-4-ene-3,17-dione	0
6beta-hydroxyestrone	0
7-ketodehydroepiandrosterone	0
7alpha-hydroxyandrost-4-ene-3,17-dione	0
7alpha-hydroxydehydroepiandrosterone	0
7beta-hydroxydehydroepiandrosterone	0
7beta-hydroxyepiandrosterone	0
9alpha-hydroxyandrost-4-en-3,17-dione	0
9alpha-hydroxyandrosta-1,4-diene-3,17-dione	0
adrenosterone	1
andrastin A	3
andrastin B +	3
andrastin C +	3
andrastin D +	0
andrastin E	0
andrastin F	0
androst-4-ene-3,17-dione +	42
androst-5-ene-3,17-dione	1
androsta-1,4,6-triene-3,17-dione	0
androsta-1,4-diene-3,17-dione	0
androstane-3,17-dione +	2
androsterone +	13
androsterone sulfate	0
dehydroepiandrosterone +	120
dehydroepiandrosterone sulfate	31
epiandrosterone +	0
epiandrosterone 3-beta-D-glucoside	0
epiandrosterone sulfate	0
epietiocholanolone	0
equilenin	1
equilin +	13
estra-1(10),4-diene-2,3,17-trione	0
estra-1,5(10)-diene-3,4,17-trione	0
estrone +	128
estrone 3-O-(beta-D-glucuronide)	1
estrone 3-sulfate	24
etiocholanolone 3-glucuronide	0
etiocholanolone hemisuccinate	0
exemestane	33
formestane	6
pyridinestrone-3-carboxylic acid	0
Path 2
Term	Annotations
CHEBI ontology	19880
subatomic particle	19878
composite particle	19878
hadron	19878
baryon	19878
nucleon	19878
atomic nucleus	19878
atom	19878
main group element atom	19817
p-block element atom	19817
carbon group element atom	19757
carbon atom	19754
organic molecular entity	19754
heteroorganic entity	19512
organochalcogen compound	19275
organooxygen compound	19191
carbonyl compound	18914
ketone	17263
oxo steroid	10532
17-oxo steroid	268
(3beta,5alpha,7alpha)-3,7-dihydroxyandrostan-17-one	0
(5alpha)-androst-3-en-17-one	0
11beta-hydroxyandrost-4-ene-3,17-dione	0
15alpha-hydroxyestrone	0
16alpha-hydroxyandrost-4-ene-3,17-dione	0
16alpha-hydroxydehydroepiandrosterone	0
16alpha-hydroxydehydroepiandrosterone 3-sulfate	0
16alpha-hydroxyestrone +	0
16alpha-hydroxyestrone 16-O-(beta-D-glucuronide)	0
16alpha-hydroxyestrone 3-O-(beta-D-glucuronide)	0
16beta-hydroxyestrone	0
19-hydroxyandrost-4-ene-3,17-dione	0
19-norandrosterone	0
1alpha-hydroxyandrost-4-ene-3,17-dione	0
2-hydroxy-3-O-methyl estrone	0
2-hydroxyestrone 2-O-(beta-D-glucuronide)	0
2-hydroxyestrone 3-O-(beta-D-glucuronide)	0
2-methoxyestrone +	1
2-methoxyestrone 3-O-(beta-D-glucuronide)	0
3,17-dioxoandrost-4-en-19-al	0
3-(2-allyloxy)estra-1,3,5(10)-triene-16,17-dione 16-oxime	0
3alpha-hydroxy-5beta-androstan-17-one +	2
3beta-(2-diethylaminoethoxy)androst-5-en-17-one	0
3beta-hydroxy-5alpha-androstane-7,17-dione	0
4-hydroxyestrone +	5
4-hydroxyestrone 3-O-(beta-D-glucuronide)	0
4-hydroxyestrone 4-O-(beta-D-glucuronide)	0
4-methoxyestrone +	0
4-methoxyestrone 3-O-(beta-D-glucuronide)	0
5alpha-androst-1-ene-3,17-dione	0
5alpha-androstan-1,3,17-trione	0
6alpha-hydroxyestrone	0
6beta-hydroxyandrost-4-ene-3,17-dione	0
6beta-hydroxyestrone	0
7-ketodehydroepiandrosterone	0
7alpha-hydroxyandrost-4-ene-3,17-dione	0
7alpha-hydroxydehydroepiandrosterone	0
7beta-hydroxydehydroepiandrosterone	0
7beta-hydroxyepiandrosterone	0
9alpha-hydroxyandrost-4-en-3,17-dione	0
9alpha-hydroxyandrosta-1,4-diene-3,17-dione	0
adrenosterone	1
andrastin A	3
andrastin B +	3
andrastin C +	3
andrastin D +	0
andrastin E	0
andrastin F	0
androst-4-ene-3,17-dione +	42
androst-5-ene-3,17-dione	1
androsta-1,4,6-triene-3,17-dione	0
androsta-1,4-diene-3,17-dione	0
androstane-3,17-dione +	2
androsterone +	13
androsterone sulfate	0
dehydroepiandrosterone +	120
dehydroepiandrosterone sulfate	31
epiandrosterone +	0
epiandrosterone 3-beta-D-glucoside	0
epiandrosterone sulfate	0
epietiocholanolone	0
equilenin	1
equilin +	13
estra-1(10),4-diene-2,3,17-trione	0
estra-1,5(10)-diene-3,4,17-trione	0
estrone +	128
estrone 3-O-(beta-D-glucuronide)	1
estrone 3-sulfate	24
etiocholanolone 3-glucuronide	0
etiocholanolone hemisuccinate	0
exemestane	33
formestane	6
pyridinestrone-3-carboxylic acid	0

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