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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Maduramicin
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Accession:CHEBI:189929 term browser browse the term
Synonyms:exact_synonym: azane;2-[(2R,3S,4S,5R,6S)-6-[(1R)-1-[(2S,5R,7S,8R,9S)-2-[(2R,5S)-5-[(2R,3S,5R)-3-[(2R,4S,5S,6S)-4,5-dimethoxy-6-methyloxan-2-yl]oxy-5-[(2S,3S,5R,6S)-6-hydroxy-3,5,6-trimethyloxan-2-yl]oxolan-2-yl]-5-methyloxolan-2-yl]-7-hydroxy-2,8-dimethyl-1,10-dioxaspiro[4.5]decan-9-yl]ethyl]-2-hydroxy-4,5-dimethoxy-3-methyloxan-2-yl]acetic acid
 related_synonym: Formula=C47H80O17.H3N;   InChI=1S/C47H80O17.H3N/c1-23-18-24(2)45(9,51)61-36(23)31-19-32(58-35-20-30(53-10)40(55-12)28(6)57-35)42(59-31)44(8)15-14-33(60-44)43(7)16-17-46(64-43)21-29(48)25(3)37(62-46)26(4)38-41(56-13)39(54-11)27(5)47(52,63-38)22-34(49)50;/h23-33,35-42,48,51-52H,14-22H2,1-13H3,(H,49,50);1H3/t23-,24+,25+,26+,27-,28-,29-,30-,31+,32-,33+,35+,36-,37-,38-,39-,40-,41-,42+,43-,44-,45-,46+,47+;/m0./s1;   InChIKey=WQGJEAMPBSZCIF-HKSLRPGUSA-N;   SMILES=O1[C@]([C@@]2(O[C@]([C@@]3(O[C@](C[C@@H]3O[C@H]4O[C@H]([C@H](OC)[C@@H](OC)C4)C)([C@]5(O[C@](O)([C@@H](C[C@@H]5C)C)C)[H])[H])[H])(CC2)C)[H])(CC[C@@]16O[C@@]([C@@H]([C@@H](O)C6)C)([C@H]([C@@]7(O[C@@](O)([C@H]([C@H](OC)[C@H]7OC)C)CC(O)=O)[H])C)[H])C.N
 xref: CAS:84878-61-5;   Chemspider:61862;   DrugBank:DB11525;   KEGG:D04830
 xref_mesh: MESH:C018091


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Maduramicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization EXP maduramicin affects the localization of AIFM1 protein CTD PMID:29047155 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Arf6 ARF GTPase 6 decreases expression
multiple interactions		 EXP maduramicin results in decreased expression of ARF6 protein
ATP6V0C protein affects the reaction [maduramicin results in decreased expression of ARF6 protein]; bafilomycin A1 inhibits the reaction [maduramicin results in decreased expression of ARF6 protein]		 CTD PMID:37394175 NCBI chr 6:87,853,742...87,854,890
Ensembl chr 6:87,840,142...87,874,114 		JBrowse link
G Atp6v0a1 ATPase H+ transporting V0 subunit a1 increases expression EXP maduramicin results in increased expression of ATP6V0A1 protein CTD PMID:37394175 NCBI chr10:85,935,802...85,989,901
Ensembl chr10:85,935,854...85,989,895 		JBrowse link
G Atp6v0c ATPase H+ transporting V0 subunit C multiple interactions
increases expression		 EXP ATP6V0C protein affects the reaction [maduramicin results in decreased expression of ARF6 protein]; ATP6V0C protein affects the reaction [maduramicin results in increased expression of RAB7A protein]
maduramicin results in increased expression of ATP6V0C protein		 CTD PMID:37394175 NCBI chr10:13,196,204...13,202,580
Ensembl chr10:13,196,204...13,201,500 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO maduramicin results in increased expression of BAD protein CTD PMID:31229567 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO maduramicin results in increased expression of BAK1 protein CTD PMID:31229567 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases expression		 ISO
EXP		 Acetylcysteine inhibits the reaction [maduramicin results in increased expression of CASP3 protein modified form]; JUN gene mutant form inhibits the reaction [maduramicin results in increased expression of CASP3 protein modified form]; PPP5C protein inhibits the reaction [maduramicin results in increased expression of CASP3 protein modified form]
maduramicin results in increased cleavage of CASP3 protein
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [maduramicin results in increased cleavage of CASP3 protein]		 CTD PMID:29047155 PMID:31229567 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases cleavage EXP maduramicin results in increased cleavage of CASP8 protein CTD PMID:29047155 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO maduramicin results in decreased expression of CCND1 protein CTD PMID:31229567 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Egf epidermal growth factor multiple interactions EXP maduramicin affects the reaction [EGF protein affects the degradation of EGFR protein]; maduramicin affects the reaction [EGF protein affects the expression of LDLR protein]; maduramicin affects the reaction [EGF protein affects the phosphorylation of EGFR protein] CTD PMID:37394175 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP maduramicin affects the reaction [EGF protein affects the degradation of EGFR protein]; maduramicin affects the reaction [EGF protein affects the phosphorylation of EGFR protein] CTD PMID:37394175 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Hras HRas proto-oncogene, GTPase increases expression EXP maduramicin results in increased expression of HRAS mRNA; maduramicin results in increased expression of HRAS protein CTD PMID:33890316 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation
multiple interactions		 EXP
ISO		 maduramicin results in increased phosphorylation of JUN protein
Acetylcysteine inhibits the reaction [maduramicin results in increased phosphorylation of JUN protein]; JUN gene mutant form inhibits the reaction [maduramicin results in increased expression of CASP3 protein modified form]; PPP5C protein inhibits the reaction [maduramicin results in increased phosphorylation of JUN protein]		 CTD PMID:31229567 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 increases expression EXP maduramicin results in increased expression of LAMP1 protein CTD PMID:37394175 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883 		JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions EXP maduramicin affects the reaction [EGF protein affects the expression of LDLR protein] CTD PMID:37394175 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 decreases response to substance
multiple interactions		 EXP MAP2K1 protein results in decreased susceptibility to maduramicin
MAP2K1 protein inhibits the reaction [maduramicin results in decreased phosphorylation of MAPK1 protein]; MAP2K1 protein inhibits the reaction [maduramicin results in decreased phosphorylation of MAPK3 protein]		 CTD PMID:29241734 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions		 EXP maduramicin results in decreased phosphorylation of MAPK1 protein
MAP2K1 protein inhibits the reaction [maduramicin results in decreased phosphorylation of MAPK1 protein]; PPP2CA protein mutant form inhibits the reaction [maduramicin results in decreased phosphorylation of MAPK1 protein]		 CTD PMID:29241734 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions		 EXP maduramicin results in decreased phosphorylation of MAPK3 protein
MAP2K1 protein inhibits the reaction [maduramicin results in decreased phosphorylation of MAPK3 protein]; PPP2CA protein mutant form inhibits the reaction [maduramicin results in decreased phosphorylation of MAPK3 protein]		 CTD PMID:29241734 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions		 EXP
ISO		 maduramicin results in increased phosphorylation of MAPK8 protein
Acetylcysteine inhibits the reaction [maduramicin results in increased phosphorylation of MAPK8 protein]; PPP5C protein inhibits the reaction [maduramicin results in increased phosphorylation of MAPK8 protein]		 CTD PMID:31229567 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions		 ISO
EXP		 maduramicin results in increased phosphorylation of MAPK9 protein
Acetylcysteine inhibits the reaction [maduramicin results in increased phosphorylation of MAPK9 protein]; PPP5C protein inhibits the reaction [maduramicin results in increased phosphorylation of MAPK9 protein]		 CTD PMID:31229567 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions		 EXP maduramicin results in increased cleavage of PARP1 protein
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [maduramicin results in increased cleavage of PARP1 protein]		 CTD PMID:29047155 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha multiple interactions EXP PPP2CA protein mutant form inhibits the reaction [maduramicin results in decreased phosphorylation of MAPK1 protein]; PPP2CA protein mutant form inhibits the reaction [maduramicin results in decreased phosphorylation of MAPK3 protein] CTD PMID:29241734 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862 		JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit decreases expression
multiple interactions		 EXP
ISO		 maduramicin results in decreased expression of PPP5C protein
PPP5C protein inhibits the reaction [maduramicin results in increased expression of CASP3 protein modified form]; PPP5C protein inhibits the reaction [maduramicin results in increased phosphorylation of JUN protein]; PPP5C protein inhibits the reaction [maduramicin results in increased phosphorylation of MAPK8 protein]; PPP5C protein inhibits the reaction [maduramicin results in increased phosphorylation of MAPK9 protein]		 CTD PMID:31229567 NCBI chr 1:77,690,203...77,714,507
Ensembl chr 1:77,690,208...77,714,456 		JBrowse link
G Rab11a RAB11a, member RAS oncogene family decreases expression EXP maduramicin results in decreased expression of RAB11A protein CTD PMID:37394175 NCBI chr 8:65,223,698...65,246,461
Ensembl chr 8:65,222,949...65,246,525 		JBrowse link
G Rab7a RAB7A, member RAS oncogene family increases expression
multiple interactions		 EXP maduramicin results in increased expression of RAB7A protein
ATP6V0C protein affects the reaction [maduramicin results in increased expression of RAB7A protein]		 CTD PMID:37394175 NCBI chr 4:120,461,966...120,510,756
Ensembl chr 4:120,461,963...120,506,889 		JBrowse link
G Rac1 Rac family small GTPase 1 increases expression EXP maduramicin results in increased expression of RAC1 mRNA; maduramicin results in increased expression of RAC1 protein CTD PMID:33890316 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Sqstm1 sequestosome 1 increases expression EXP maduramicin results in increased expression of SQSTM1 protein CTD PMID:29047155 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO maduramicin results in increased expression of TNFRSF10A protein CTD PMID:31229567 NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467 		JBrowse link
G Tnfsf10 TNF superfamily member 10 increases expression EXP maduramicin results in increased expression of TNFSF10 protein CTD PMID:29047155 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
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  CHEBI ontology 19874
    chemical entity 19872
      atom 19872
        nonmetal atom 19794
          oxygen atom 19535
            oxygen molecular entity 19535
              organooxygen compound 19184
                carbohydrates and carbohydrate derivatives 15285
                  carbohydrate derivative 14300
                    glycosyl compound 13062
                      glycoside 11830
                        Maduramicin 29
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  CHEBI ontology 19874
    subatomic particle 19872
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                  main group element atom 19811
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                          organic molecular entity 19748
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                              organochalcogen compound 19268
                                organooxygen compound 19184
                                  carbohydrates and carbohydrate derivatives 15285
                                    carbohydrate 15285
                                      carbohydrate derivative 14300
                                        glycosyl compound 13062
                                          glycoside 11830
                                            Maduramicin 29
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