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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:varespladib
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Accession:CHEBI:189668 term browser browse the term
Definition:A member of the class of indoles that is 1H-indole substituted by benzyl, ethyl, oxamoyl, and carboxymethoxy groups at positions 1, 2, 3, and 4, respectively. It is an oral secretory phospholipase A2 inhibitor and exhibits anti-inflammatory effects.
Synonyms:exact_synonym: ({3-[amino(oxo)acetyl]-1-benzyl-2-ethyl-1H-indol-4-yl}oxy)acetic acid
 related_synonym: 2-[2-ethyl-3-oxamoyl-1-(phenylmethyl)indol-4-yl]oxyethanoic acid;   2-[[3-(2-Amino-2-oxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetic acid;   A-001;   Formula=C21H20N2O5;   InChI=1S/C21H20N2O5/c1-2-14-19(20(26)21(22)27)18-15(9-6-10-16(18)28-12-17(24)25)23(14)11-13-7-4-3-5-8-13/h3-10H,2,11-12H2,1H3,(H2,22,27)(H,24,25);   InChIKey=BHLXTPHDSZUFHR-UHFFFAOYSA-N;   LY 315920;   LY315920;   S 5920;   SMILES=CCC1=C(C(=O)C(N)=O)C2=C(OCC(O)=O)C=CC=C2N1CC1=CC=CC=C1;   varespladibum
 xref: CAS:172732-68-2;   Chemspider:137248;   DrugBank:DB11909;   HMDB:HMDB0259766;   KEGG:D08107
 xref_mesh: MESH:C117948
 xref: PDBeChem:VRD;   PMID:10027849;   PMID:12626975;   PMID:15467263;   PMID:16096451;   PMID:20809869;   PMID:21446779;   PMID:23071714;   PMID:27571102;   PMID:29439513;   PMID:30447275;   PMID:30453607;   PMID:30518149;   PMID:31748642;   PMID:32093386;   PMID:32442717;   PMID:32485836;   PMID:32512199;   PMID:32560391;   PMID:32889027;   PMID:33359941;   PMID:33865953;   PMID:33922825;   PMID:34143707;   PMID:34562493;   PMID:34744732;   PMID:34774704;   PMID:34929179;   PMID:35095526;   Patent:CN101838232;   Wikipedia:Varespladib
 cyclic_relationship: is_conjugate_acid_of CHEBI:189666



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varespladib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F10 coagulation factor X multiple interactions ISO varespladib inhibits the reaction [micrurus venom results in decreased activity of F10 protein] CTD PMID:33197555 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP [Antivenins co-treated with varespladib] inhibits the reaction [micrurus venom results in increased expression of GPT protein] CTD PMID:34774704 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Pla2g2a phospholipase A2 group IIA decreases activity
multiple interactions
EXP
ISO
varespladib results in decreased activity of PLA2G2A protein
varespladib inhibits the reaction [PLA2G2A protein results in increased abundance of Thromboxane A2 metabolite]; varespladib inhibits the reaction [PLA2G2A protein results in increased abundance of Thromboxane B2]
CTD PMID:10027849 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014
JBrowse link
varespladib methyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions ISO varespladib methyl inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA]; varespladib methyl inhibits the reaction [IL1B protein results in increased expression of MMP2 mRNA]; varespladib methyl inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; varespladib methyl inhibits the reaction [IL1B protein results in increased expression of MMP9 mRNA]; varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of MMP1 protein]; varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of MMP2 protein]; varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein]; varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of MMP9 protein]; varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of PLA2G2A protein] CTD PMID:19765281 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO varespladib methyl inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA]; varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of MMP1 protein] CTD PMID:19765281 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO varespladib methyl inhibits the reaction [IL1B protein results in increased expression of MMP2 mRNA]; varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of MMP2 protein] CTD PMID:19765281 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO varespladib methyl inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein] CTD PMID:19765281 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO varespladib methyl inhibits the reaction [IL1B protein results in increased expression of MMP9 mRNA]; varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of MMP9 protein] CTD PMID:19765281 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Pla2g2a phospholipase A2 group IIA multiple interactions ISO varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of PLA2G2A protein] CTD PMID:19765281 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      application 19714
        anti-inflammatory agent 16684
          anti-inflammatory drug 14974
            varespladib 8
              varespladib methyl 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19771
                          organic molecular entity 19771
                            heteroorganic entity 19528
                              organochalcogen compound 19290
                                organooxygen compound 19206
                                  carbon oxoacid 18675
                                    carboxylic acid 18672
                                      carboacyl group 17712
                                        univalent carboacyl group 17712
                                          carbamoyl group 17563
                                            carboxamide 17563
                                              dicarboxylic acid amide 3153
                                                dicarboxylic acid monoamide 683
                                                  varespladib 8
                                                    varespladib methyl 6
paths to the root