CHEBI ONTOLOGY - ANNOTATIONS |
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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
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Term: | nicotine |
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Accession: | CHEBI:18723
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browse the term
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Definition: | A racemate composed of equimolar amounts of (R)- and (S)-nicotine. |
Synonyms: | exact_synonym: | rac-3-(1-methylpyrrolidin-2-yl)pyridine |
| related_synonym: | (+-)-3-(1-Methyl-2-pyrrolidinyl)pyridine; (R,S)-nicotine; (RS)-nicotine; Nicotin; Nikotin |
| xref: | Beilstein:82111; CAS:22083-74-5; DrugBank:DB00184; HMDB:HMDB0014330; KEGG:C16150; KNApSAcK:C00002057 |
| xref_mesh: | MESH:D009538 |
| xref: | PMID:10751565; PMID:11192937; PMID:11471991; PMID:11559179; PMID:11682702; PMID:11714820; PMID:11719700; PMID:11801622; PMID:11818389; PMID:11860617; PMID:12197757; PMID:12700710; PMID:12965231; PMID:14715938; PMID:15183514; PMID:15251917; PMID:15313135; PMID:15458549; PMID:15707677; PMID:15894687; PMID:15960296; PMID:15961264; PMID:16496293; PMID:16950410; PMID:17167832; PMID:17206646; PMID:17438652; PMID:17498149; PMID:17942810; PMID:18077004; PMID:18311975; PMID:18380035; PMID:18383130; PMID:18651995; PMID:18922921; PMID:19100331; PMID:19287496; PMID:19389046; PMID:19465085; PMID:20338106; PMID:20528766; PMID:21636612; PMID:21822688; PMID:21945235; PMID:22129149; PMID:22218403; PMID:22331007; PMID:22377934; PMID:22448647; PMID:22459798; PMID:22529223; PMID:22573728; PMID:22585541; PMID:22589423; PMID:22770225; PMID:22792725; PMID:22855884; PMID:22930863; PMID:22935730; PMID:23108361; PMID:23117126; PMID:7097594; PMID:7564279; PMID:7566693; PMID:7807214; PMID:7896575; PMID:8156919; PMID:8545712; PMID:8764340; PMID:9203638; PMID:9450943; PMID:9621392; Reaxys:82108; UM-BBD_compID:c0468; Wikipedia:Nicotine |
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Aacs |
acetoacetyl-CoA synthetase |
decreases expression increases methylation |
EXP |
Nicotine results in decreased expression of AACS mRNA Nicotine results in increased methylation of AACS promoter |
CTD |
PMID:26776438 |
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NCBI chr12:31,113,098...31,156,411
Ensembl chr12:31,113,098...31,160,954
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Aatk |
apoptosis-associated tyrosine kinase |
increases expression |
ISO |
Nicotine results in increased expression of AATK mRNA |
CTD |
PMID:18247414 |
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NCBI chr10:105,290,752...105,327,219
Ensembl chr10:105,291,585...105,327,112
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Abca1 |
ATP binding cassette subfamily A member 1 |
decreases expression multiple interactions |
ISO EXP |
Nicotine results in decreased expression of ABCA1 mRNA; Nicotine results in decreased expression of ABCA1 protein GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCA1 mRNA]; GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCA1 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 protein] |
CTD |
PMID:30036686 |
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NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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Abcg1 |
ATP binding cassette subfamily G member 1 |
decreases expression multiple interactions increases expression |
ISO EXP |
Nicotine results in decreased expression of ABCG1 mRNA; Nicotine results in decreased expression of ABCG1 protein GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCG1 mRNA]; GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCG1 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 protein] Nicotine results in increased expression of ABCG1 protein |
CTD |
PMID:30036686 PMID:31629012 |
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NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
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Abcg2 |
ATP binding cassette subfamily G member 2 |
increases expression |
ISO |
Nicotine results in increased expression of ABCG2 mRNA |
CTD |
PMID:17997037 |
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NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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Abtb3 |
ankyrin repeat and BTB domain containing 3 |
increases expression |
ISO |
Nicotine results in increased expression of ABTB3 mRNA |
CTD |
PMID:21955143 PMID:23825647 |
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NCBI chr 7:18,035,151...18,310,718
Ensembl chr 7:18,036,083...18,310,834
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Acaa2 |
acetyl-CoA acyltransferase 2 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ACAA2 mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ACAA2 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249
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Acaca |
acetyl-CoA carboxylase alpha |
increases expression |
EXP |
Nicotine results in increased expression of ACACA mRNA |
CTD |
PMID:24368177 PMID:29155039 |
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NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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Acan |
aggrecan |
decreases expression multiple interactions |
EXP ISO |
Nicotine results in decreased expression of ACAN mRNA; Nicotine results in decreased expression of ACAN protein NLRP3 protein affects the reaction [Nicotine results in decreased expression of ACAN mRNA] |
CTD |
PMID:29660438 PMID:31299270 PMID:34245815 PMID:39098741 |
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NCBI chr 1:132,981,582...133,044,416
Ensembl chr 1:132,981,582...133,043,627
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Ace |
angiotensin I converting enzyme |
increases expression |
ISO |
Nicotine results in increased expression of ACE mRNA |
CTD |
PMID:11166759 |
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NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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Ache |
acetylcholinesterase |
decreases activity multiple interactions increases activity |
EXP |
Nicotine results in decreased activity of ACHE protein Nicotine inhibits the reaction [Chlorpyrifos results in decreased activity of ACHE protein] Nicotine results in increased activity of ACHE protein |
CTD |
PMID:20097188 PMID:21633116 PMID:23033686 |
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NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Acot13 |
acyl-CoA thioesterase 13 |
decreases expression |
ISO |
Nicotine results in decreased expression of ACOT13 mRNA |
CTD |
PMID:17997037 |
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NCBI chr17:40,240,378...40,252,851
Ensembl chr17:40,240,378...40,252,851
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Acp1 |
acid phosphatase 1 |
decreases expression |
ISO |
Nicotine results in decreased expression of ACP1 mRNA |
CTD |
PMID:17997037 |
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NCBI chr 6:47,506,380...47,522,021
Ensembl chr 6:47,506,380...47,522,021
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Acsl1 |
acyl-CoA synthetase long-chain family member 1 |
increases splicing |
ISO |
Nicotine results in increased splicing of ACSL1 mRNA alternative form |
CTD |
PMID:23825647 |
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NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
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Acsl6 |
acyl-CoA synthetase long-chain family member 6 |
multiple interactions increases expression |
ISO EXP |
Mecamylamine inhibits the reaction [Nicotine results in increased expression of ACSL6 protein] Nicotine results in increased expression of ACSL6 mRNA |
CTD |
PMID:22205969 |
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NCBI chr10:38,439,914...38,501,182
Ensembl chr10:38,440,080...38,498,757
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Acta1 |
actin, alpha 1, skeletal muscle |
increases expression decreases expression |
ISO EXP |
Nicotine results in increased expression of ACTA1 mRNA Nicotine results in decreased expression of ACTA1 mRNA |
CTD |
PMID:17997037 PMID:27782041 |
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NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742
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Acta2 |
actin alpha 2, smooth muscle |
multiple interactions increases expression |
ISO EXP |
Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; Nicotine promotes the reaction [Quartz results in increased expression of ACTA2 protein] Nicotine results in increased expression of ACTA2 mRNA; Nicotine results in increased expression of ACTA2 protein Bungarotoxins inhibits the reaction [Nicotine results in increased expression of ACTA2 protein]; Nicotine promotes the reaction [Arginine results in increased expression of ACTA2 protein] |
CTD |
PMID:33640489 PMID:34153408 PMID:36720419 PMID:36868510 |
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NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Actb |
actin, beta |
increases expression |
ISO |
Nicotine results in increased expression of ACTB mRNA |
CTD |
PMID:17997037 |
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NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
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Actr1a |
actin related protein 1A |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ACTR1A mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ACTR1A mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 1:245,237,821...245,256,618
Ensembl chr 1:245,237,826...245,256,495
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Actrt2 |
actin-related protein T2 |
decreases expression |
EXP |
Nicotine results in decreased expression of ACTRT2 mRNA |
CTD |
PMID:27782041 |
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NCBI chr 5:165,236,092...165,237,492
Ensembl chr 5:165,236,086...165,237,629
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Ada |
adenosine deaminase |
increases activity multiple interactions |
EXP |
Nicotine results in increased activity of ADA protein Sodium Acetate inhibits the reaction [Nicotine results in increased activity of ADA protein] |
CTD |
PMID:31857090 |
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NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
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Adam19 |
ADAM metallopeptidase domain 19 |
increases expression |
ISO |
Nicotine results in increased expression of ADAM19 mRNA |
CTD |
PMID:23825647 |
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NCBI chr10:30,491,362...30,583,115
Ensembl chr10:30,491,405...30,583,105
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Adcy7 |
adenylate cyclase 7 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ADCY7 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ADCY7 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr19:18,740,875...18,798,924
Ensembl chr19:18,740,875...18,776,311
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Adgra1 |
adhesion G protein-coupled receptor A1 |
decreases expression |
ISO |
Nicotine results in decreased expression of ADGRA1 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 1:194,629,744...194,673,254
Ensembl chr 1:194,629,726...194,672,550
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Adgrg1 |
adhesion G protein-coupled receptor G1 |
increases expression |
ISO |
Nicotine results in increased expression of ADGRG1 mRNA |
CTD |
PMID:23825647 |
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NCBI chr19:10,003,963...10,041,122
Ensembl chr19:10,003,975...10,041,108
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Adgrl1 |
adhesion G protein-coupled receptor L1 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ADGRL1 mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ADGRL1 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr19:24,202,405...24,244,137
Ensembl chr19:24,204,360...24,244,139
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Adipor2 |
adiponectin receptor 2 |
increases expression |
EXP |
Nicotine results in increased expression of ADIPOR2 mRNA |
CTD |
PMID:22265867 |
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NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355
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Adk |
adenosine kinase |
increases expression |
ISO |
Nicotine results in increased expression of ADK mRNA |
CTD |
PMID:17997037 |
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NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510
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Adm2 |
adrenomedullin 2 |
multiple interactions |
EXP |
[Cholecalciferol co-treated with Nicotine] results in decreased expression of ADM2 protein |
CTD |
PMID:19910445 |
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NCBI chr 7:120,393,179...120,394,965
Ensembl chr 7:120,393,179...120,396,331
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Adnp |
activity-dependent neuroprotector homeobox |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ADNP mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ADNP mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 3:156,886,921...156,921,500
Ensembl chr 3:156,891,381...156,917,312
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Adora2a |
adenosine A2a receptor |
decreases expression |
ISO |
Nicotine results in decreased expression of ADORA2A mRNA |
CTD |
PMID:21955143 |
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NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
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Adrb1 |
adrenoceptor beta 1 |
multiple interactions increases expression |
ISO |
[Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased susceptibility to Nicotine Nicotine results in increased expression of ADRB1 mRNA |
CTD |
PMID:17003101 PMID:17369603 |
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NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259
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Adrb2 |
adrenoceptor beta 2 |
multiple interactions increases expression |
ISO |
[ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased abundance of Dinoprostone]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] which results in decreased susceptibility to Nicotine Nicotine results in increased expression of ADRB2 mRNA |
CTD |
PMID:17003101 PMID:17369603 |
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NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
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Adtrp |
androgen-dependent TFPI-regulating protein |
increases expression |
ISO |
Nicotine results in increased expression of ADTRP mRNA |
CTD |
PMID:23825647 |
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NCBI chr17:22,907,758...22,993,834
Ensembl chr17:22,930,740...22,993,826
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Agtr1a |
angiotensin II receptor, type 1a |
increases expression |
EXP |
Nicotine results in increased expression of AGTR1A protein |
CTD |
PMID:22691361 |
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NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
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Agtr1b |
angiotensin II receptor, type 1b |
increases expression |
EXP |
Nicotine results in increased expression of AGTR1B mRNA |
CTD |
PMID:22728133 |
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NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232
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Agtr2 |
angiotensin II receptor, type 2 |
decreases expression affects expression |
EXP |
Nicotine results in decreased expression of AGTR2 mRNA; Nicotine results in decreased expression of AGTR2 protein Nicotine affects the expression of AGTR2 protein |
CTD |
PMID:19429393 PMID:22691361 |
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NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057
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Ahr |
aryl hydrocarbon receptor |
increases expression |
ISO |
Nicotine results in increased expression of AHR mRNA |
CTD |
PMID:34171359 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Ak3 |
adenylate kinase 3 |
increases expression |
ISO |
Nicotine results in increased expression of AK3 mRNA |
CTD |
PMID:17456735 |
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NCBI chr 1:226,737,472...226,764,647
Ensembl chr 1:226,739,318...226,764,625
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Ak5 |
adenylate kinase 5 |
increases expression |
ISO |
Nicotine results in increased expression of AK5 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 2:241,397,297...241,581,483
Ensembl chr 2:241,397,297...241,581,458
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Akr1a1 |
aldo-keto reductase family 1 member A1 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of AKR1A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of AKR1A1 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674
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Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions increases expression increases phosphorylation decreases phosphorylation |
ISO EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein]; [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of EIF4EBP1 protein; [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of FOXO1 protein; [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3A protein; [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3B protein; CDK1 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; CDK2 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; CHRNA7 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; CSNK2A1 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of AKT1 protein modified form]; CYP1A1 protein affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein]; Nicotine affects the reaction [Camptothecin affects the phosphorylation of AKT1 protein]; Nicotine affects the reaction [Fluorouracil affects the phosphorylation of AKT1 protein]; Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein Nicotine results in decreased phosphorylation of AKT1 protein Nicotine results in increased expression of AKT1 mRNA |
CTD |
PMID:12511591 PMID:15983034 PMID:20727180 PMID:24095863 PMID:30836163 PMID:31783125 PMID:31945395 PMID:34171359 PMID:35929799 PMID:38229321 More...
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Akt2 |
AKT serine/threonine kinase 2 |
affects expression increases expression |
EXP ISO |
Nicotine affects the expression of AKT2 mRNA Nicotine results in increased expression of AKT2 mRNA |
CTD |
PMID:31945395 PMID:31972234 |
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NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
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Alad |
aminolevulinate dehydratase |
decreases activity |
ISO |
Nicotine results in decreased activity of ALAD protein |
CTD |
PMID:8687997 |
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NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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Alb |
albumin |
increases expression multiple interactions decreases expression |
EXP ISO |
Nicotine results in increased expression of ALB protein dexpanthenol inhibits the reaction [Nicotine results in decreased expression of ALB protein] |
CTD |
PMID:25662863 PMID:36720419 PMID:38229321 |
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
increases activity multiple interactions |
ISO |
Nicotine results in increased activity of ALDH1A1 protein [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ALDH1A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ALDH1A1 mRNA] |
CTD |
PMID:20230807 PMID:23219715 |
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NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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Alox12 |
arachidonate 12-lipoxygenase, 12S type |
increases expression |
ISO |
Nicotine results in increased expression of ALOX12 mRNA |
CTD |
PMID:16254210 |
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NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542
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Alox5 |
arachidonate 5-lipoxygenase |
multiple interactions increases expression |
ISO |
[RTKI cpd co-treated with AG 1879] inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]; AG 1879 inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]; MK-886 inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]; RTKI cpd inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]; U 0126 inhibits the reaction [Nicotine results in increased expression of ALOX5 mRNA] Nicotine results in increased expression of ALOX5 mRNA; Nicotine results in increased expression of ALOX5 protein |
CTD |
PMID:14569062 PMID:20061081 |
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NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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Amd1 |
adenosylmethionine decarboxylase 1 |
increases expression |
ISO |
Nicotine results in increased expression of AMD1 mRNA |
CTD |
PMID:16949557 |
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NCBI chr20:43,695,783...43,711,476
Ensembl chr20:43,697,237...43,711,476
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Amhr2 |
anti-Mullerian hormone receptor type 2 |
decreases expression |
ISO |
Nicotine results in decreased expression of AMHR2 mRNA |
CTD |
PMID:18247414 |
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NCBI chr 7:133,579,152...133,588,874
Ensembl chr 7:133,579,393...133,588,258
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G |
Angpt4 |
angiopoietin 4 |
increases expression |
ISO |
Nicotine results in increased expression of ANGPT4 mRNA |
CTD |
PMID:23825647 |
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NCBI chr 3:140,420,389...140,454,213
Ensembl chr 3:140,420,389...140,453,583
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G |
Angptl4 |
angiopoietin-like 4 |
decreases expression |
EXP |
Nicotine results in decreased expression of ANGPTL4 mRNA |
CTD |
PMID:32512034 |
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NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
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G |
Ano3 |
anoctamin 3 |
decreases expression |
ISO |
Nicotine results in decreased expression of ANO3 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 3:97,235,671...97,550,090
Ensembl chr 3:97,238,354...97,550,154
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G |
Anxa1 |
annexin A1 |
decreases expression |
EXP |
Nicotine results in decreased expression of ANXA1 mRNA |
CTD |
PMID:26776438 |
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NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
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G |
Apeh |
acylaminoacyl-peptide hydrolase |
decreases expression |
ISO |
Nicotine results in decreased expression of APEH mRNA |
CTD |
PMID:16949557 |
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NCBI chr 8:108,773,791...108,782,903
Ensembl chr 8:108,773,794...108,782,933
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G |
Apex1 |
apurinic/apyrimidinic endodeoxyribonuclease 1 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of APEX1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of APEX1 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
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G |
Api5 |
apoptosis inhibitor 5 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of API5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of API5 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 3:80,378,096...80,403,259
Ensembl chr 3:80,378,096...80,403,264
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G |
Apoe |
apolipoprotein E |
increases expression |
ISO |
Nicotine results in increased expression of APOE mRNA |
CTD |
PMID:17997037 |
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NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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G |
App |
amyloid beta precursor protein |
multiple interactions decreases expression increases metabolic processing |
ISO EXP |
[Nicotine results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form; Bungarotoxins inhibits the reaction [Nicotine inhibits the reaction [Copper results in increased expression of APP protein]]; Mecamylamine inhibits the reaction [Nicotine inhibits the reaction [Copper results in increased expression of APP protein]]; Nicotine inhibits the reaction [Copper promotes the reaction [APP protein binds to APP protein]]; Nicotine inhibits the reaction [Copper results in increased expression of APP mRNA]; Nicotine inhibits the reaction [Copper results in increased expression of APP protein]; Tubocurarine inhibits the reaction [[Nicotine results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form]; Tubocurarine inhibits the reaction [Nicotine results in increased metabolism of APP protein] Nicotine results in decreased expression of APP mRNA; Nicotine results in decreased expression of APP protein Nicotine results in decreased expression of APP protein alternative form APP protein modified form inhibits the reaction [Nicotine results in increased secretion of Acetylcholine]; spiro(imidazo-(1,2-a)pyridine-3,2-indan)-2(3H)-one inhibits the reaction [APP protein modified form inhibits the reaction [Nicotine results in increased secretion of Acetylcholine]] |
CTD |
PMID:16474004 PMID:16627626 PMID:17135361 PMID:29618714 |
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NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Aqp4 |
aquaporin 4 |
increases expression |
ISO |
Nicotine results in increased expression of AQP4 mRNA |
CTD |
PMID:21955143 |
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NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
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G |
Arc |
activity-regulated cytoskeleton-associated protein |
increases expression |
ISO |
Nicotine results in increased expression of ARC mRNA |
CTD |
PMID:23825647 |
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NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
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G |
Arf1 |
ARF GTPase 1 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ARF1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ARF1 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr10:43,997,983...44,014,461
Ensembl chr10:43,997,986...44,014,434
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G |
Arf3 |
ARF GTPase 3 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ARF3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ARF3 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 7:129,886,082...129,912,022
Ensembl chr 7:129,886,082...129,912,002
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G |
Arglu1 |
arginine and glutamate rich 1 |
increases expression |
ISO |
Nicotine results in increased expression of ARGLU1 mRNA |
CTD |
PMID:16949557 |
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NCBI chr16:80,753,300...80,777,350
Ensembl chr16:80,753,315...80,777,349
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G |
Arhgef26 |
Rho guanine nucleotide exchange factor 26 |
multiple interactions |
ISO |
[Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of ARHGEF26 mRNA |
CTD |
PMID:28065790 |
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NCBI chr 2:146,740,336...146,850,918
Ensembl chr 2:146,739,631...146,850,819
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G |
Arhgef7 |
Rho guanine nucleotide exchange factor 7 |
decreases expression |
ISO |
Nicotine results in decreased expression of ARHGEF7 mRNA |
CTD |
PMID:12588870 |
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NCBI chr16:77,671,021...77,782,593
Ensembl chr16:77,671,023...77,782,697
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G |
Arid1a |
AT-rich interaction domain 1A |
decreases expression |
ISO |
Nicotine results in decreased expression of ARID1A mRNA |
CTD |
PMID:17997037 |
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NCBI chr 5:145,908,173...145,981,552
Ensembl chr 5:145,908,181...145,985,564
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G |
Arl15 |
ARF like GTPase 15 |
multiple interactions |
ISO |
[Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of ARL15 mRNA |
CTD |
PMID:28065790 |
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NCBI chr 2:45,438,221...45,822,562
Ensembl chr 2:45,438,242...45,822,559
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G |
Arpp21 |
cAMP regulated phosphoprotein 21 |
decreases expression |
ISO |
Nicotine results in decreased expression of ARPP21 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 8:112,034,636...112,199,273
Ensembl chr 8:112,034,642...112,194,297
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G |
Arrb1 |
arrestin, beta 1 |
multiple interactions |
ISO |
ARRB1 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; ARRB1 protein affects the reaction [Nicotine results in increased phosphorylation of and results in increased activity of SRC protein] |
CTD |
PMID:16862215 |
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NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061
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G |
Ascl1 |
achaete-scute family bHLH transcription factor 1 |
decreases expression |
EXP |
Nicotine results in decreased expression of ASCL1 mRNA |
CTD |
PMID:28555334 |
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NCBI chr 7:21,903,136...21,906,003
Ensembl chr 7:21,903,126...21,905,993
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G |
Ascl2 |
achaete-scute family bHLH transcription factor 2 |
decreases expression |
EXP |
Nicotine results in decreased expression of ASCL2 mRNA |
CTD |
PMID:24368670 |
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NCBI chr 1:198,148,999...198,151,406
Ensembl chr 1:198,148,999...198,151,406
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G |
Aspm |
assembly factor for spindle microtubules |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ASPM mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ASPM mRNA] |
CTD |
PMID:20230807 |
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NCBI chr13:51,074,849...51,123,755
Ensembl chr13:51,074,849...51,123,755
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G |
Atf3 |
activating transcription factor 3 |
increases expression |
ISO |
Nicotine results in increased expression of ATF3 mRNA |
CTD |
PMID:17456735 PMID:24927667 |
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NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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G |
Atf6 |
activating transcription factor 6 |
multiple interactions |
EXP |
Nicotine inhibits the reaction [Tunicamycin results in increased expression of ATF6 protein] |
CTD |
PMID:18477628 |
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NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
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G |
Atm |
ATM serine/threonine kinase |
multiple interactions |
ISO |
Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of ATM protein modified form] |
CTD |
PMID:23907605 |
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NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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G |
Atoh1 |
atonal bHLH transcription factor 1 |
multiple interactions increases expression |
ISO |
Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased expression of ATOH1 mRNA] |
CTD |
PMID:23056257 |
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NCBI chr 4:93,912,068...93,914,163
Ensembl chr 4:93,912,068...93,914,154
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G |
Atp5f1a |
ATP synthase F1 subunit alpha |
decreases expression |
EXP |
Nicotine results in decreased expression of ATP5F1A protein |
CTD |
PMID:28681937 |
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NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
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G |
Atp5f1e |
ATP synthase F1 subunit epsilon |
increases splicing |
ISO |
Nicotine results in increased splicing of ATP5F1E mRNA alternative form |
CTD |
PMID:23825647 |
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NCBI chr 3:163,259,072...163,261,974
Ensembl chr 3:163,260,476...163,261,450
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G |
Atp6v0a4 |
ATPase H+ transporting V0 subunit a4 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ATP6V0A4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ATP6V0A4 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 4:66,760,163...66,842,126
Ensembl chr 4:66,760,159...66,842,110
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G |
Atp9a |
ATPase phospholipid transporting 9A (putative) |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ATP9A mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ATP9A mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 3:157,360,354...157,467,628
Ensembl chr 3:157,360,359...157,467,818
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G |
Atr |
ATR serine/threonine kinase |
multiple interactions |
ISO |
Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of ATR protein modified form] |
CTD |
PMID:23907605 |
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NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
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G |
Atrn |
attractin |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ATRN mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ATRN mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 3:118,110,320...118,244,326
Ensembl chr 3:118,110,229...118,244,322
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G |
Atrx |
ATRX, chromatin remodeler |
increases expression decreases expression |
ISO |
Nicotine results in increased expression of ATRX mRNA Nicotine results in decreased expression of ATRX mRNA |
CTD |
PMID:16949557 PMID:21955143 |
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NCBI chr X:70,850,981...70,997,330
Ensembl chr X:70,850,981...70,997,330
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G |
Avp |
arginine vasopressin |
decreases expression increases secretion |
ISO EXP |
Nicotine results in decreased expression of AVP mRNA Nicotine results in increased secretion of AVP protein alternative form |
CTD |
PMID:3681699 PMID:17456735 PMID:28555334 |
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NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
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G |
B4galt2 |
beta-1,4-galactosyltransferase 2 |
decreases expression |
ISO |
Nicotine results in decreased expression of B4GALT2 mRNA |
CTD |
PMID:17997037 |
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NCBI chr 5:131,412,541...131,422,573
Ensembl chr 5:131,412,541...131,421,013
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G |
Bad |
BCL2-associated agonist of cell death |
decreases expression decreases phosphorylation |
ISO EXP |
Nicotine results in decreased expression of BAD mRNA Nicotine results in decreased phosphorylation of BAD protein |
CTD |
PMID:18247414 PMID:20447445 |
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NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Bap1 |
BRCA1 associated deubiquitinase 1 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of BAP1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAP1 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr16:6,446,709...6,455,535
Ensembl chr16:6,446,709...6,455,535
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases phosphorylation decreases expression multiple interactions increases expression affects localization |
ISO EXP |
Nicotine results in increased phosphorylation of BAX protein Nicotine results in decreased expression of BAX protein 3-methyladenine inhibits the reaction [Nicotine results in increased expression of BAX protein]; [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in decreased expression of BAX protein; MK-886 inhibits the reaction [Nicotine results in decreased expression of BAX protein]; Nicotine inhibits the reaction [[Cisplatin co-treated with Etoposide] affects the localization of BAX protein]; PRKCZ protein affects the reaction [Nicotine results in increased phosphorylation of BAX protein] Nicotine results in decreased expression of BAX mRNA; Nicotine results in decreased expression of BAX protein Nicotine results in increased expression of BAX mRNA Nicotine affects the localization of BAX protein Nicotine results in increased expression of BAX mRNA; Nicotine results in increased expression of BAX protein dexpanthenol inhibits the reaction [Nicotine results in increased expression of BAX protein]; Folic Acid inhibits the reaction [Nicotine results in increased expression of BAX protein] |
CTD |
PMID:15831280 PMID:17135361 PMID:17525161 PMID:18203686 PMID:18676776 PMID:20061081 PMID:20106947 PMID:20339300 PMID:29972271 PMID:30259641 PMID:31783125 PMID:33010382 PMID:34153408 PMID:38229321 More...
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcas1 |
brain enriched myelin associated protein 1 |
increases expression |
ISO |
Nicotine results in increased expression of BCAS1 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 3:159,136,077...159,219,072
Ensembl chr 3:159,136,083...159,219,106
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G |
Bcl11b |
BCL11 transcription factor B |
increases expression |
ISO |
Nicotine results in increased expression of BCL11B mRNA |
CTD |
PMID:21955143 |
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NCBI chr 6:126,834,531...126,927,720
Ensembl chr 6:126,834,531...126,928,224
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions increases expression decreases expression increases phosphorylation |
ISO EXP |
3-methyladenine inhibits the reaction [Nicotine results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of BCL2 protein]; edelfosine inhibits the reaction [Nicotine results in increased phosphorylation of BCL2 protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of BCL2 protein]; MK-886 inhibits the reaction [Nicotine results in increased expression of BCL2 protein]; Nicotine inhibits the reaction [Aflatoxin B1 results in decreased expression of BCL2 protein] Nicotine results in increased expression of BCL2 mRNA; Nicotine results in increased expression of BCL2 protein; Nicotine results in increased expression of BCL2 protein modified form Nicotine results in decreased expression of BCL2 mRNA; Nicotine results in decreased expression of BCL2 protein Folic Acid inhibits the reaction [Nicotine results in decreased expression of BCL2 protein] royal jelly inhibits the reaction [Nicotine results in decreased expression of BCL2 mRNA] |
CTD |
PMID:12421819 PMID:15831280 PMID:18448488 PMID:18676776 PMID:20061081 PMID:20339300 PMID:20727180 PMID:22743290 PMID:29972271 PMID:30076938 PMID:30836163 PMID:30896085 PMID:31783125 PMID:33010382 PMID:34153408 More...
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2a1 |
BCL2-related protein A1 |
decreases expression |
ISO |
Nicotine results in decreased expression of BCL2A1 mRNA |
CTD |
PMID:18247414 |
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NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression multiple interactions |
ISO EXP |
Nicotine results in decreased expression of BCL2L1 mRNA resveratrol inhibits the reaction [Nicotine results in decreased expression of BCL2L1 mRNA] Nicotine results in decreased expression of BCL2L1 protein |
CTD |
PMID:22687363 PMID:38229321 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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G |
Bcl2l10 |
Bcl2-like 10 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of BCL2L10 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BCL2L10 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 8:76,107,326...76,113,373
Ensembl chr 8:76,107,326...76,113,367
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G |
Bdnf |
brain-derived neurotrophic factor |
affects response to substance multiple interactions increases secretion affects expression increases expression |
ISO EXP |
BDNF gene polymorphism affects the susceptibility to Nicotine methyllycaconitine inhibits the reaction [Nicotine results in increased secretion of BDNF protein] Nicotine affects the expression of BDNF mRNA Nicotine results in increased expression of BDNF mRNA [Nicotine co-treated with Quartz] results in increased expression of BDNF protein |
CTD |
PMID:9503263 PMID:9832142 PMID:16790237 PMID:17186223 PMID:20426880 PMID:36868510 More...
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NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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G |
Becn1 |
beclin 1 |
increases expression multiple interactions |
ISO |
Nicotine results in increased expression of BECN1 mRNA Nicotine promotes the reaction [Dextran Sulfate results in increased expression of BECN1 protein] dorsomorphin inhibits the reaction [Nicotine promotes the reaction [Dextran Sulfate results in increased expression of BECN1 protein]]; Nicotine promotes the reaction [Dextran Sulfate results in increased expression of BECN1 protein] |
CTD |
PMID:30605750 PMID:31926917 |
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NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Bglap |
bone gamma-carboxyglutamate protein |
increases expression multiple interactions decreases expression |
ISO EXP |
Nicotine results in increased expression of BGLAP Tubocurarine inhibits the reaction [Nicotine results in increased expression of BGLAP] Nicotine results in decreased expression of BGLAP Nicotine results in decreased expression of BGLAP mRNA |
CTD |
PMID:19436947 PMID:29981921 |
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NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
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G |
Birc2 |
baculoviral IAP repeat-containing 2 |
increases expression multiple interactions |
ISO |
Nicotine results in increased expression of BIRC2 protein Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC2 protein] |
CTD |
PMID:20727180 |
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NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
multiple interactions increases expression |
ISO |
Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC5 protein]; Hexamethonium affects the reaction [Nicotine results in increased expression of BIRC5 protein]; Nicotine inhibits the reaction [RB1 protein binds to BIRC5 promoter]; Nicotine promotes the reaction [E2F1 protein binds to BIRC5 promoter] Nicotine results in increased expression of BIRC5 mRNA; Nicotine results in increased expression of BIRC5 protein |
CTD |
PMID:16601104 PMID:19896492 PMID:20727180 PMID:21267677 |
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NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Bmi1 |
BMI1 proto-oncogene, polycomb ring finger |
increases expression multiple interactions |
ISO |
Nicotine results in increased expression of BMI1 mRNA; Nicotine results in increased expression of BMI1 protein SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of BMI1 mRNA] |
CTD |
PMID:23219715 |
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NCBI chr17:81,332,175...81,341,625
Ensembl chr17:81,332,214...81,388,690
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G |
Bmp4 |
bone morphogenetic protein 4 |
decreases expression |
EXP |
Nicotine results in decreased expression of BMP4 mRNA |
CTD |
PMID:20339300 |
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NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
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G |
Bmp7 |
bone morphogenetic protein 7 |
multiple interactions |
ISO |
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of CS mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of HGF mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of MMP2 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A protein; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PRDM16 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of UCP1 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of UCP1 protein; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of VEGFA mRNA |
CTD |
PMID:33091441 |
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NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788
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G |
Bnip3 |
BCL2 interacting protein 3 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of BNIP3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BNIP3 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
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G |
Bok |
BCL2 family apoptosis regulator BOK |
decreases expression |
ISO |
Nicotine results in decreased expression of BOK mRNA |
CTD |
PMID:21955143 |
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NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476
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G |
Braf |
B-Raf proto-oncogene, serine/threonine kinase |
decreases expression |
ISO |
Nicotine results in decreased expression of BRAF mRNA; Nicotine results in decreased expression of BRAF protein |
CTD |
PMID:17135361 |
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NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
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G |
Brca1 |
BRCA1, DNA repair associated |
decreases expression multiple interactions |
ISO |
Nicotine results in decreased expression of BRCA1 mRNA Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of BRCA1 protein modified form] |
CTD |
PMID:18247414 PMID:23907605 |
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NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
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G |
Brd2 |
bromodomain containing 2 |
increases expression |
ISO |
Nicotine results in increased expression of BRD2 mRNA |
CTD |
PMID:33640489 |
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NCBI chr20:4,727,078...4,735,389
Ensembl chr20:4,728,151...4,735,388
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G |
Bst2 |
bone marrow stromal cell antigen 2 |
multiple interactions |
ISO |
[nickel chloride co-treated with Nicotine] results in increased expression of BST2 mRNA |
CTD |
PMID:37951547 |
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NCBI chr16:18,216,605...18,220,979
Ensembl chr16:18,217,407...18,220,979
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G |
Btf3 |
basic transcription factor 3 |
decreases expression |
ISO |
Nicotine results in decreased expression of BTF3 mRNA |
CTD |
PMID:18247414 |
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NCBI chr 2:29,659,764...29,666,898
Ensembl chr 2:29,659,231...29,666,879 Ensembl chr13:29,659,231...29,666,879
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G |
Btg2 |
BTG anti-proliferation factor 2 |
increases expression |
ISO |
Nicotine results in increased expression of BTG2 mRNA |
CTD |
PMID:17456735 |
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NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
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G |
Btk |
Bruton tyrosine kinase |
decreases expression |
ISO |
Nicotine results in decreased expression of BTK mRNA |
CTD |
PMID:18247414 |
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NCBI chr X:97,722,796...97,762,315
Ensembl chr X:97,722,802...97,761,853
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G |
C1r |
complement C1r |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of C1R mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of C1R mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 4:157,412,718...157,423,483
Ensembl chr 4:157,412,692...157,423,484
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G |
C1s |
complement C1s |
multiple interactions |
ISO |
Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of C1S mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303
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G |
C3ar1 |
complement C3a receptor 1 |
increases expression |
ISO |
Nicotine results in increased expression of C3AR1 mRNA |
CTD |
PMID:23825647 |
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NCBI chr 4:156,074,747...156,084,680
Ensembl chr 4:156,075,389...156,084,701
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G |
C5ar1 |
complement C5a receptor 1 |
decreases expression |
ISO |
Nicotine results in decreased expression of C5AR1 mRNA |
CTD |
PMID:18247414 |
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NCBI chr 1:76,948,622...76,959,826
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G |
C7 |
complement C7 |
multiple interactions increases expression |
ISO |
alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of C7 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of C7 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of C7 mRNA] |
CTD |
PMID:16949557 |
|
NCBI chr 2:54,088,116...54,165,102
Ensembl chr 2:54,088,116...54,158,535
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G |
Cacna1c |
calcium voltage-gated channel subunit alpha1 C |
increases expression |
ISO |
Nicotine results in increased expression of CACNA1C protein |
CTD |
PMID:11756415 |
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NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
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G |
Cacna1d |
calcium voltage-gated channel subunit alpha1 D |
increases expression |
ISO |
Nicotine results in increased expression of CACNA1D protein |
CTD |
PMID:11756415 |
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NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215
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G |
Cacna1f |
calcium voltage-gated channel subunit alpha1 F |
increases expression |
ISO |
Nicotine results in increased expression of CACNA1F mRNA |
CTD |
PMID:11756415 |
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NCBI chr X:14,868,096...14,896,413
Ensembl chr X:14,868,024...14,896,413
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G |
Cacna1h |
calcium voltage-gated channel subunit alpha1 H |
increases expression |
EXP |
Nicotine results in increased expression of CACNA1H mRNA |
CTD |
PMID:27782041 |
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NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376
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G |
Cacna2d1 |
calcium voltage-gated channel auxiliary subunit alpha2delta 1 |
increases expression |
ISO |
Nicotine results in increased expression of CACNA2D1 protein |
CTD |
PMID:11756415 |
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NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969
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G |
Cacng1 |
calcium voltage-gated channel auxiliary subunit gamma 1 |
decreases expression |
EXP |
Nicotine results in decreased expression of CACNG1 mRNA |
CTD |
PMID:27782041 |
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NCBI chr10:92,652,924...92,665,612
Ensembl chr10:92,652,614...92,665,783
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G |
Cadm3 |
cell adhesion molecule 3 |
increases expression |
EXP |
Nicotine results in increased expression of CADM3 mRNA |
CTD |
PMID:27782041 |
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NCBI chr13:85,784,785...85,817,412
Ensembl chr13:85,786,483...85,817,749
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G |
Calb1 |
calbindin 1 |
increases expression multiple interactions |
EXP |
Nicotine results in increased expression of CALB1 protein Mecamylamine inhibits the reaction [Nicotine results in increased expression of CALB1 protein] |
CTD |
PMID:11226671 |
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NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431
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G |
Calcrl |
calcitonin receptor like receptor |
multiple interactions |
EXP |
[Cholecalciferol co-treated with Nicotine] results in increased expression of CALCRL protein |
CTD |
PMID:19910445 |
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NCBI chr 3:69,428,348...69,525,910
Ensembl chr 3:69,430,120...69,525,910
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G |
Calm1 |
calmodulin 1 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CALM1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CALM1 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227
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G |
Calr |
calreticulin |
increases expression |
ISO |
Nicotine results in increased expression of CALR mRNA |
CTD |
PMID:16949557 |
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NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
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G |
Camk2a |
calcium/calmodulin-dependent protein kinase II alpha |
increases expression |
ISO |
Nicotine results in increased expression of CAMK2A mRNA |
CTD |
PMID:21955143 |
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NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
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G |
Camk4 |
calcium/calmodulin-dependent protein kinase IV |
decreases expression |
ISO |
Nicotine results in decreased expression of CAMK4 mRNA |
CTD |
PMID:17997037 |
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NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487
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G |
Camp |
cathelicidin antimicrobial peptide |
increases expression |
ISO |
Nicotine results in increased expression of CAMP mRNA |
CTD |
PMID:23825647 |
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NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543
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G |
Cap1 |
cyclase associated actin cytoskeleton regulatory protein 1 |
decreases expression |
ISO |
Nicotine results in decreased expression of CAP1 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 5:135,142,108...135,168,885
Ensembl chr 5:135,142,112...135,168,769
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G |
Capn10 |
calpain 10 |
increases expression |
ISO |
Nicotine results in increased expression of CAPN10 mRNA |
CTD |
PMID:17997037 |
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NCBI chr 9:93,498,132...93,510,494
Ensembl chr 9:93,498,478...93,510,494
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G |
Capza2 |
capping actin protein of muscle Z-line subunit alpha 2 |
increases expression |
ISO |
Nicotine results in increased expression of CAPZA2 mRNA |
CTD |
PMID:16949557 |
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NCBI chr 4:45,978,142...46,014,032
Ensembl chr 4:45,977,807...46,013,864
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G |
Car3 |
carbonic anhydrase 3 |
decreases expression |
EXP |
Nicotine results in decreased expression of CAR3 mRNA |
CTD |
PMID:27782041 |
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NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
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G |
Cartpt |
CART prepropeptide |
decreases expression |
EXP ISO |
Nicotine results in decreased expression of CARTPT protein Nicotine results in decreased expression of CARTPT mRNA |
CTD |
PMID:18247414 PMID:23623838 |
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NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713
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G |
Casp1 |
caspase 1 |
multiple interactions increases expression |
ISO EXP |
CHRNA5 protein affects the reaction [Nicotine results in increased expression of and results in increased cleavage of CASP1 protein]; Nicotine affects the reaction [Staurosporine affects the localization of CASP1 protein]; Nicotine inhibits the reaction [Staurosporine results in increased activity of CASP1 protein]; Nicotine results in increased expression of and results in increased cleavage of CASP1 protein Nicotine results in increased expression of CASP1 protein Nicotine results in increased expression of CASP1 mRNA |
CTD |
PMID:16927020 PMID:35131329 PMID:39098741 |
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NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp12 |
caspase 12 |
multiple interactions |
ISO EXP |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CASP12 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP12 mRNA] Nicotine inhibits the reaction [Tunicamycin results in increased activity of CASP12 protein] |
CTD |
PMID:18477628 PMID:20230807 |
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NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
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G |
Casp14 |
caspase 14 |
increases expression |
ISO |
Nicotine results in increased expression of CASP14 mRNA |
CTD |
PMID:23825647 |
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NCBI chr 7:10,929,759...10,932,591
Ensembl chr 7:10,926,725...10,933,405
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G |
Casp2 |
caspase 2 |
affects expression |
EXP |
Nicotine affects the expression of CASP2 mRNA |
CTD |
PMID:20426880 |
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NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
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G |
Casp3 |
caspase 3 |
multiple interactions decreases activity increases activity decreases expression increases expression affects expression increases cleavage |
ISO EXP |
geldanamycin inhibits the reaction [Nicotine results in increased activity of CASP3 protein]; MK-886 inhibits the reaction [Nicotine results in decreased expression of CASP3 protein]; Nicotine inhibits the reaction [Aflatoxin B1 results in increased cleavage of CASP3 protein]; Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of CASP3 protein modified form]; Nicotine inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Nicotine inhibits the reaction [Paclitaxel results in increased activity of CASP3 protein] Nicotine results in decreased activity of CASP3 protein [Nicotine co-treated with Polylactic Acid-Polyglycolic Acid Copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP3 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP3 protein]; Resveratrol inhibits the reaction [Nicotine results in increased expression of CASP3 mRNA]; royal jelly inhibits the reaction [Nicotine results in increased expression of CASP3 mRNA] Nicotine results in decreased expression of CASP3 mRNA; Nicotine results in decreased expression of CASP3 protein Nicotine results in increased expression of CASP3; Nicotine results in increased expression of CASP3 mRNA; Nicotine results in increased expression of CASP3 protein; Nicotine results in increased expression of CASP3 protein modified form Nicotine results in increased expression of CASP3 mRNA; Nicotine results in increased expression of CASP3 protein modified form [Ethanol co-treated with Nicotine] results in increased expression of CASP3 protein; Nicotine inhibits the reaction [Ethanol results in increased activity of CASP3 protein] Nicotine affects the expression of CASP3 mRNA Nicotine results in increased activity of CASP3 protein; Nicotine results in increased activity of CASP3 protein alternative form Nicotine results in increased cleavage of CASP3 protein |
CTD |
PMID:11701223 PMID:12115584 PMID:12218695 PMID:15831280 PMID:16237857 PMID:16949557 PMID:17135361 PMID:18203686 PMID:19815060 PMID:20061081 PMID:20106947 PMID:20383341 PMID:20426880 PMID:20447445 PMID:20457658 PMID:22687363 PMID:22743290 PMID:23907605 PMID:23933227 PMID:30896085 PMID:30959089 PMID:31678612 PMID:31783125 PMID:33010382 PMID:38229321 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
affects expression |
EXP |
Nicotine affects the expression of CASP8 mRNA |
CTD |
PMID:20426880 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
multiple interactions decreases expression increases expression |
ISO EXP |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CASP9 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP9 mRNA] Nicotine results in decreased expression of CASP9 mRNA Nicotine inhibits the reaction [[Cisplatin co-treated with Etoposide] results in increased activity of CASP9 protein] Nicotine results in increased expression of CASP9 protein dexpanthenol inhibits the reaction [Nicotine results in increased expression of CASP9 protein]; Folic Acid inhibits the reaction [Nicotine results in increased expression of CASP9 protein] |
CTD |
PMID:16949557 PMID:18676776 PMID:20230807 PMID:29972271 PMID:38229321 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions decreases activity increases activity |
EXP ISO |
[acephate co-treated with methamidophos co-treated with Nicotine] results in increased activity of CAT protein; [Ethanol co-treated with Nicotine] results in decreased activity of CAT protein; [Ethanol co-treated with Nicotine] results in increased activity of CAT protein; Folic Acid inhibits the reaction [Nicotine results in decreased activity of CAT protein] Nicotine results in increased activity of CAT protein royal jelly inhibits the reaction [Nicotine results in decreased activity of CAT protein] |
CTD |
PMID:10509436 PMID:10874619 PMID:10906423 PMID:11747978 PMID:15925865 PMID:19778253 PMID:23033686 PMID:25662863 PMID:29972271 PMID:30896085 More...
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cav2 |
caveolin 2 |
decreases expression |
ISO |
Nicotine results in decreased expression of CAV2 mRNA |
CTD |
PMID:33640489 |
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NCBI chr 4:45,616,766...45,624,144
Ensembl chr 4:45,616,712...45,624,244
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G |
Cbl |
Cbl proto-oncogene |
increases expression |
ISO |
Nicotine results in increased expression of CBL mRNA |
CTD |
PMID:18247414 |
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NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176
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G |
Cbln1 |
cerebellin 1 precursor |
increases expression |
ISO |
Nicotine results in increased expression of CBLN1 mRNA |
CTD |
PMID:21955143 |
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NCBI chr19:19,608,763...19,612,572
Ensembl chr19:19,608,716...19,612,572
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G |
Cbx3 |
chromobox 3 |
increases expression |
ISO |
Nicotine results in increased expression of CBX3 mRNA |
CTD |
PMID:16949557 |
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NCBI chr 4:80,545,450...80,559,284
Ensembl chr 4:80,546,010...80,559,283 Ensembl chr 4:80,546,010...80,559,283
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G |
Cbx5 |
chromobox 5 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CBX5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CBX5 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 7:134,333,165...134,376,102
Ensembl chr 7:134,331,335...134,375,022
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G |
Ccdc136 |
coiled-coil domain containing 136 |
increases expression |
ISO |
Nicotine results in increased expression of CCDC136 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 4:57,997,825...58,027,598
Ensembl chr 4:57,997,853...58,027,646
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G |
Ccdc159 |
coiled-coil domain containing 159 |
increases expression |
ISO |
Nicotine results in increased expression of CCDC159 mRNA |
CTD |
PMID:23825647 |
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NCBI chr 8:20,457,905...20,467,232
Ensembl chr 8:20,457,909...20,466,562
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G |
Ccdc167 |
coiled-coil domain containing 167 |
increases expression |
ISO |
Nicotine results in increased expression of CCDC167 mRNA |
CTD |
PMID:23825647 |
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NCBI chr20:7,763,927...7,782,090
Ensembl chr20:7,751,782...7,781,613
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G |
Ccdc88a |
coiled coil domain containing 88A |
increases expression |
ISO |
Nicotine results in increased expression of CCDC88A mRNA |
CTD |
PMID:17456735 |
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NCBI chr14:103,104,091...103,256,112
Ensembl chr14:103,103,513...103,252,368
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G |
Cck |
cholecystokinin |
decreases expression |
ISO |
Nicotine results in decreased expression of CCK mRNA |
CTD |
PMID:21955143 |
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NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions decreases expression decreases secretion |
ISO EXP |
Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]; ZFP36 mutant form inhibits the reaction [Nicotine results in decreased expression of CCL2 mRNA] Mecamylamine inhibits the reaction [Nicotine results in decreased expression of CCL2 mRNA] Nicotine results in decreased secretion of CCL2 protein Nicotine results in decreased expression of CCL2 mRNA; Nicotine results in decreased expression of CCL2 protein |
CTD |
PMID:15135227 PMID:15976189 PMID:22093924 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
increases expression |
ISO |
Nicotine results in increased expression of CCL5 mRNA |
CTD |
PMID:18247414 |
|
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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G |
Ccn1 |
cellular communication network factor 1 |
increases expression |
ISO |
Nicotine results in increased expression of CCN1 mRNA |
CTD |
PMID:17456735 |
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NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
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G |
Ccn2 |
cellular communication network factor 2 |
increases expression |
EXP |
Nicotine results in increased expression of CCN2 protein |
CTD |
PMID:22691361 |
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NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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G |
Ccn5 |
cellular communication network factor 5 |
increases expression |
ISO |
Nicotine results in increased expression of CCN5 mRNA |
CTD |
PMID:23825647 |
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NCBI chr 3:152,491,247...152,502,639
Ensembl chr 3:152,491,220...152,502,636
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G |
Ccna2 |
cyclin A2 |
increases expression |
ISO |
Nicotine results in increased expression of CCNA2 protein |
CTD |
PMID:18448488 PMID:20106947 |
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NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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G |
Ccnb1 |
cyclin B1 |
increases expression multiple interactions |
ISO |
Nicotine results in increased expression of CCNB1 protein [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CCNB1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCNB1 mRNA] |
CTD |
PMID:20106947 PMID:20230807 |
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NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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G |
Ccnd1 |
cyclin D1 |
multiple interactions increases expression increases activity decreases expression |
ISO EXP |
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of CCND1 protein]; MK-886 inhibits the reaction [Nicotine results in increased expression of CCND1 mRNA]; MK-886 inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; Nicotine promotes the reaction [CDK4 protein binds to CCND1 protein]; Nicotine promotes the reaction [CDK6 protein binds to CCND1 protein]; U 0126 inhibits the reaction [Nicotine results in increased expression of CCND1 protein] Nicotine results in increased expression of CCND1 mRNA; Nicotine results in increased expression of CCND1 protein Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of CCND1 mRNA] Nicotine results in increased activity of CCND1 promoter Nicotine results in decreased expression of CCND1 mRNA; Nicotine results in decreased expression of CCND1 protein |
CTD |
PMID:15574422 PMID:15983034 PMID:17135361 PMID:18448488 PMID:18805435 PMID:18835254 PMID:20061081 PMID:20106947 PMID:20727180 PMID:23056257 PMID:30836163 PMID:34153408 More...
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccnd2 |
cyclin D2 |
multiple interactions decreases expression |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CCND2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCND2 mRNA] Nicotine results in decreased expression of CCND2 protein |
CTD |
PMID:15231866 PMID:20230807 |
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NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
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G |
Ccne1 |
cyclin E1 |
multiple interactions increases expression |
ISO |
MK-886 inhibits the reaction [Nicotine results in increased expression of CCNE1 protein] |
CTD |
PMID:20061081 |
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NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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G |
Ccng2 |
cyclin G2 |
increases expression |
ISO |
Nicotine results in increased expression of CCNG2 mRNA |
CTD |
PMID:23416264 |
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NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
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G |
Ccnl2 |
cyclin L2 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CCNL2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCNL2 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 5:166,416,940...166,428,997
Ensembl chr 5:166,417,508...166,436,882
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G |
Ccr5 |
C-C motif chemokine receptor 5 |
increases expression |
ISO |
Nicotine results in increased expression of CCR5 mRNA |
CTD |
PMID:18247414 |
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NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
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G |
Ccr6 |
C-C motif chemokine receptor 6 |
decreases expression |
ISO |
Nicotine results in decreased expression of CCR6 mRNA |
CTD |
PMID:18247414 |
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NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603
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G |
Ccs |
copper chaperone for superoxide dismutase |
increases expression |
ISO |
Nicotine results in increased expression of CCS protein |
CTD |
PMID:16627626 |
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NCBI chr 1:202,113,792...202,134,931
Ensembl chr 1:202,113,804...202,134,915
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G |
Cd151 |
CD151 molecule (Raph blood group) |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CD151 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CD151 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 1:196,564,744...196,568,753
Ensembl chr 1:196,565,181...196,568,753
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G |
Cd4 |
Cd4 molecule |
decreases expression |
ISO |
Nicotine results in decreased expression of CD4 mRNA |
CTD |
PMID:18247414 |
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NCBI chr 4:157,668,878...157,695,366
Ensembl chr 4:157,668,878...157,695,191
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G |
Cd44 |
CD44 molecule |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CD44 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CD44 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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G |
Cd46 |
CD46 molecule |
increases expression |
ISO |
Nicotine results in increased expression of CD46 mRNA |
CTD |
PMID:16949557 |
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NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445
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G |
Cd59b |
CD59b molecule |
increases expression |
ISO |
Nicotine results in increased expression of CD59 mRNA |
CTD |
PMID:18247414 |
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NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847
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G |
Cd68 |
Cd68 molecule |
multiple interactions |
EXP |
[Nicotine results in increased abundance of Cotinine] which results in increased expression of CD68 mRNA |
CTD |
PMID:29617909 |
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NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697
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G |
Cd86 |
CD86 molecule |
increases expression |
EXP |
Nicotine results in increased expression of CD86 mRNA |
CTD |
PMID:27782041 |
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NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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G |
Cd9 |
CD9 molecule |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CD9 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CD9 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 4:158,256,328...158,289,136
Ensembl chr 4:158,256,328...158,289,222
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G |
Cdc25a |
cell division cycle 25A |
multiple interactions |
ISO |
Nicotine inhibits the reaction [E2F4 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [E2F5 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [RB1 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [RBL1 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [RBL2 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F1 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F2 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F3 protein binds to CDC25A promoter] |
CTD |
PMID:16862215 |
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NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
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G |
Cdc42 |
cell division cycle 42 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CDC42 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CDC42 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111
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G |
Cdc6 |
cell division cycle 6 |
multiple interactions |
ISO |
Nicotine inhibits the reaction [E2F4 protein binds to CDC6 promoter]; Nicotine inhibits the reaction [E2F5 protein binds to CDC6 promoter]; Nicotine inhibits the reaction [RB1 protein binds to CDC6 promoter]; Nicotine inhibits the reaction [RBL1 protein binds to CDC6 promoter]; Nicotine inhibits the reaction [RBL2 protein binds to CDC6 promoter]; Nicotine promotes the reaction [E2F1 protein binds to CDC6 promoter]; Nicotine promotes the reaction [E2F2 protein binds to CDC6 promoter]; Nicotine promotes the reaction [E2F3 protein binds to CDC6 promoter] |
CTD |
PMID:16862215 |
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NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011
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G |
Cdh1 |
cadherin 1 |
multiple interactions decreases expression |
ISO |
MK-886 inhibits the reaction [Nicotine results in decreased expression of CDH1 mRNA]; U 0126 inhibits the reaction [Nicotine results in decreased expression of CDH1 mRNA] Nicotine results in decreased expression of CDH1 mRNA; Nicotine results in decreased expression of CDH1 protein [Nicotine co-treated with Quartz] results in increased expression of CDH1 protein |
CTD |
PMID:18844224 PMID:20061081 PMID:23219715 PMID:36868510 |
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cdh11 |
cadherin 11 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CDH11 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CDH11 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr19:2,148,447...2,305,754
Ensembl chr19:2,148,458...2,304,272
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G |
Cdh2 |
cadherin 2 |
multiple interactions |
ISO |
[Nicotine co-treated with Quartz] results in increased expression of CDH2 protein; staurosporine aglycone inhibits the reaction [[Nicotine co-treated with Quartz] results in increased expression of CDH2 protein] |
CTD |
PMID:36868510 |
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NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
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G |
Cdk1 |
cyclin-dependent kinase 1 |
increases expression multiple interactions |
ISO |
Nicotine results in increased expression of CDK1 protein CDK1 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; CHRNA7 affects the reaction [Nicotine results in increased expression of CDK1 protein] |
CTD |
PMID:35929799 |
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NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Cdk13 |
cyclin-dependent kinase 13 |
increases expression |
ISO |
Nicotine results in increased expression of CDK13 mRNA |
CTD |
PMID:16949557 |
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NCBI chr17:47,251,145...47,344,675
Ensembl chr17:47,251,163...47,341,721
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G |
Cdk2 |
cyclin dependent kinase 2 |
multiple interactions |
ISO |
CDK2 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:35929799 |
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NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdk4 |
cyclin-dependent kinase 4 |
multiple interactions decreases expression |
ISO |
Bungarotoxins inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]; Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]; Hexamethonium inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]; Nicotine promotes the reaction [CDK4 protein binds to CCND1 protein]; Nicotine promotes the reaction [NFATC2 protein results in decreased expression of CDK4 protein]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein] Nicotine results in decreased expression of CDK4 mRNA; Nicotine results in decreased expression of CDK4 protein |
CTD |
PMID:15231866 PMID:17135361 PMID:18805435 |
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NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Cdk6 |
cyclin-dependent kinase 6 |
multiple interactions increases expression |
ISO |
Nicotine promotes the reaction [CDK6 protein binds to CCND1 protein] Nicotine results in increased expression of CDK6 mRNA |
CTD |
PMID:16949557 PMID:18805435 |
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NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
decreases expression multiple interactions increases expression |
ISO |
Nicotine results in decreased expression of CDKN1A protein 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Nicotine results in decreased expression of CDKN1A protein]; Nicotine inhibits the reaction [Cisplatin results in increased expression of CDKN1A protein]; Nicotine inhibits the reaction [Gemcitabine results in increased expression of CDKN1A protein]; Nicotine inhibits the reaction [Paclitaxel results in increased expression of CDKN1A protein] Nicotine results in increased expression of CDKN1A protein Nicotine results in increased expression of CDKN1A mRNA; Nicotine results in increased expression of CDKN1A protein Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN1A mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN1A protein]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CDKN1A mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CDKN1A protein] |
CTD |
PMID:16011614 PMID:16601104 PMID:18805435 PMID:20727180 PMID:30272249 PMID:31507073 PMID:32473187 More...
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
decreases expression multiple interactions |
ISO |
Nicotine results in decreased expression of CDKN1B protein 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Nicotine results in decreased expression of CDKN1B protein]; Nicotine results in increased expression of and results in increased stability of CDKN1B protein |
CTD |
PMID:15231866 PMID:18805435 |
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NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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G |
Cdkn2a |
cyclin-dependent kinase inhibitor 2A |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN2A mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN2A protein]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CDKN2A mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CDKN2A protein] Nicotine results in increased expression of CDKN2A mRNA; Nicotine results in increased expression of CDKN2A protein |
CTD |
PMID:32473187 |
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NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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G |
Cds1 |
CDP-diacylglycerol synthase 1 |
increases splicing |
ISO |
Nicotine results in increased splicing of CDS1 mRNA alternative form |
CTD |
PMID:23825647 |
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NCBI chr14:7,820,328...7,882,943
Ensembl chr14:7,820,351...7,882,681
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G |
Ceacam1 |
CEA cell adhesion molecule 1 |
increases expression |
ISO |
Nicotine results in increased expression of CEACAM1 mRNA |
CTD |
PMID:17997037 |
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NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
multiple interactions increases expression affects expression |
EXP ISO |
[Nicotine results in increased abundance of Cotinine] which results in increased expression of CEBPA protein Nicotine results in increased expression of CEBPA mRNA Nicotine affects the expression of CEBPA mRNA |
CTD |
PMID:29617909 PMID:31622651 PMID:31972234 |
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NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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G |
Cebpb |
CCAAT/enhancer binding protein beta |
increases expression multiple interactions |
ISO EXP |
Nicotine results in increased expression of CEBPB mRNA [Nicotine results in increased abundance of Cotinine] which results in increased expression of CEBPB mRNA |
CTD |
PMID:18805435 PMID:29617909 |
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NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
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G |
Celf6 |
CUGBP, Elav-like family member 6 |
increases expression |
EXP |
Nicotine results in increased expression of CELF6 mRNA |
CTD |
PMID:27782041 |
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NCBI chr 8:59,975,095...60,006,060
Ensembl chr 8:59,975,088...60,005,041
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G |
Cenpe |
centromere protein E |
increases expression |
ISO |
Nicotine results in increased expression of CENPE mRNA |
CTD |
PMID:16949557 |
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NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669
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G |
Cers6 |
ceramide synthase 6 |
multiple interactions |
ISO |
[Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of CERS6 mRNA |
CTD |
PMID:28065790 |
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NCBI chr 3:53,630,637...53,879,692
Ensembl chr 3:53,630,959...53,876,848
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G |
Cetn2 |
centrin 2 |
decreases expression |
ISO |
Nicotine results in decreased expression of CETN2 mRNA |
CTD |
PMID:17997037 |
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NCBI chr X:150,769,944...150,774,833
Ensembl chr X:150,769,953...150,774,919
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G |
Cetn3 |
centrin 3 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CETN3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CETN3 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 2:12,089,025...12,101,828
Ensembl chr 2:12,089,226...12,101,828
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G |
Cfap43 |
cilia and flagella associated protein 43 |
decreases expression |
ISO |
Nicotine results in decreased expression of CFAP43 mRNA |
CTD |
PMID:23825647 |
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NCBI chr 1:246,625,259...246,712,438
Ensembl chr 1:246,625,262...246,712,443
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G |
Cga |
glycoprotein hormones, alpha polypeptide |
increases expression |
ISO |
Nicotine results in increased expression of CGA mRNA |
CTD |
PMID:23825647 |
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NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191
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G |
Cgref1 |
cell growth regulator with EF hand domain 1 |
increases expression |
ISO |
Nicotine results in increased expression of CGREF1 mRNA |
CTD |
PMID:23825647 |
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NCBI chr 6:25,431,846...25,443,853
Ensembl chr 6:25,431,799...25,443,852
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G |
Chat |
choline O-acetyltransferase |
decreases activity multiple interactions increases activity |
EXP |
Nicotine results in decreased activity of CHAT protein Nicotine inhibits the reaction [Vanadium results in decreased expression of CHAT protein]; Nicotine promotes the reaction [Bucladesine results in increased expression of CHAT protein] Nicotine results in increased activity of CHAT protein |
CTD |
PMID:20361958 PMID:21633116 PMID:22119111 PMID:30247698 |
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NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093
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G |
Chd2 |
chromodomain helicase DNA binding protein 2 |
increases expression |
ISO |
Nicotine results in increased expression of CHD2 mRNA |
CTD |
PMID:16949557 |
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NCBI chr 1:127,188,146...127,317,041
Ensembl chr 1:127,190,059...127,300,502
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G |
Chek2 |
checkpoint kinase 2 |
multiple interactions |
ISO |
Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of CHEK2 protein modified form] |
CTD |
PMID:23907605 |
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NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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G |
Chga |
chromogranin A |
multiple interactions increases expression increases activity |
ISO EXP |
CHGA protein alternative form inhibits the reaction [Nicotine results in increased activity of CHGA promoter]; Chlorisondamine inhibits the reaction [Nicotine results in increased activity of CHGA promoter] Nicotine results in increased expression of CHGA mRNA |
CTD |
PMID:1907749 PMID:12799369 |
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NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398
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G |
Chgb |
chromogranin B |
increases expression |
EXP |
Nicotine results in increased expression of CHGB mRNA; Nicotine results in increased expression of CHGB protein |
CTD |
PMID:1907749 |
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NCBI chr 3:120,043,824...120,057,169
Ensembl chr 3:120,043,738...120,057,166
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G |
Chrna1 |
cholinergic receptor nicotinic alpha 1 subunit |
multiple interactions affects binding |
ISO |
PLAU inhibits the reaction [Nicotine binds to CHRNA1 protein] |
CTD |
PMID:19690163 |
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NCBI chr 3:58,454,763...58,469,832
Ensembl chr 3:58,454,744...58,469,840
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G |
Chrna10 |
cholinergic receptor nicotinic alpha 10 subunit |
increases expression |
EXP |
Nicotine results in increased expression of CHRNA10 mRNA |
CTD |
PMID:30959089 PMID:31846720 |
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NCBI chr 1:156,487,279...156,494,277
Ensembl chr 1:156,487,279...156,491,476
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G |
Chrna2 |
cholinergic receptor nicotinic alpha 2 subunit |
affects response to substance multiple interactions |
ISO EXP |
CHRNA2 gene mutant form affects the susceptibility to Nicotine Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein] nicotine affects binding competes with [Epibatidine binds to Chrna2 protein] nicotine affects binding to Chrna2 protein; nicotine inhibits the reaction [epibatidine affects binding to Chrna2 protein] in rat retina |
CTD RGD |
PMID:9454827 PMID:19383498 PMID:15016836 PMID:16129735 |
RGD:2303194, RGD:2303195 |
NCBI chr15:40,342,317...40,358,601
Ensembl chr15:40,342,317...40,358,601
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G |
Chrna3 |
cholinergic receptor nicotinic alpha 3 subunit |
decreases expression multiple interactions affects response to substance increases expression increases activity |
ISO EXP |
Nicotine results in decreased expression of CHRNA3 mRNA CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein] CHRNA3 protein affects the susceptibility to Nicotine Nicotine results in increased expression of CHRNA3 mRNA Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Nicotine analog binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein] Nicotine results in increased activity of CHRNA3 protein Nicotine affects binding [Epibatidine binds to Chrna3 protein] nicotine affects binding [Epibatidine binds to Chrna3 protein] |
CTD RGD |
PMID:9454827 PMID:10336510 PMID:11600638 PMID:12628473 PMID:15275829 PMID:15615518 PMID:17135361 PMID:18450646 PMID:19483072 PMID:29293602 PMID:34628512 PMID:15016836 PMID:16129735 More...
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RGD:2303194, RGD:2303195 |
NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165
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G |
Chrna4 |
cholinergic receptor nicotinic alpha 4 subunit |
affects binding multiple interactions increases expression affects response to substance increases response to substance decreases expression |
ISO EXP |
Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein] [CHRNA4 protein binds to CHRNB2 protein] which results in increased susceptibility to Nicotine; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Nicotine inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Nicotine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]; Rosiglitazone inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein] CHRNA4 gene polymorphism affects the susceptibility to Nicotine; CHRNA4 protein affects the susceptibility to Nicotine; CHRNA4 protein mutant form affects the susceptibility to Nicotine CHRNA4 protein mutant form results in increased susceptibility to Nicotine Nicotine results in decreased expression of CHRNA4 mRNA [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide co-treated with Nicotine] inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of CHRNA4 protein]; cytisine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]; Hexamethonium inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]; Nicotine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CHRNA4 protein]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein] Nicotine results in increased expression of CHRNA4 mRNA; Nicotine results in increased expression of CHRNA4 protein 1-(5-azido-6-chloropyridin-3-ylmethyl)-2-nitroiminoimidazolidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine; [Nicotine co-treated with Benzo(a)pyrene] results in decreased expression of [CHRNA4 protein binds to CHRNB2 protein]; Bungarotoxins inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]; Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in increased expression of CHRNA4 mRNA]; imidacloprid analog inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; N-(5-azido-6-chloropyridin-3-ylmethyl)-N'-methyl-N''-nitroguanidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]; Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine results in increased expression of [CHRNA4 protein binds to CHRNB2 protein] Nicotine analog binds to [CHRNA4 protein binds to CHRNB2 protein]; Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein] nicotine affects binding to Chrna4 protein; nicotine competes with [Epibatidine binds to Chrna4 protein] nicotine affects binding to Chrna4 protein; nicotine inhibits the reaction [epibatidine affects binding to Chrna4 protein] in rat retina |
CTD RGD |
PMID:7756618 PMID:9336329 PMID:9454827 PMID:10336510 PMID:10377228 PMID:10734154 PMID:10942032 PMID:10945867 PMID:11124396 PMID:11150171 PMID:14500745 PMID:14645658 PMID:15551346 PMID:15615518 PMID:16339034 PMID:16915382 PMID:17135361 PMID:18448488 PMID:19139119 PMID:19252481 PMID:19404753 PMID:19481067 PMID:19594327 PMID:20060465 PMID:20106947 PMID:20943775 PMID:24368670 PMID:28555334 PMID:29293602 PMID:29486207 PMID:30247698 PMID:31846720 PMID:34153408 PMID:34628512 PMID:15016836 PMID:16129735 More...
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RGD:2303194, RGD:2303195 |
NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
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G |
Chrna5 |
cholinergic receptor nicotinic alpha 5 subunit |
increases response to substance multiple interactions decreases expression increases expression affects response to substance |
ISO |
CHRNA5 gene polymorphism results in increased susceptibility to Nicotine 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; alpha-conotoxin MII inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; alpha-conotoxin MII inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein]; CHRNA5 mutant form inhibits the reaction [Nicotine results in increased expression of HIF1A protein]; CHRNA5 mutant form inhibits the reaction [Nicotine results in increased expression of VEGFA protein]; CHRNA5 protein affects the reaction [Nicotine results in increased expression of and results in increased cleavage of CASP1 protein]; CHRNA5 protein affects the reaction [Nicotine results in increased expression of NLRP3 protein]; CHRNA5 protein affects the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; CHRNA5 protein affects the reaction [Nicotine results in increased secretion of IL18 protein]; CHRNA5 protein affects the reaction [Nicotine results in increased secretion of IL1B protein]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein]; Go 6976 inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; Go 6976 inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; manumycin inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; manumycin inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein] Nicotine results in decreased expression of CHRNA5 mRNA Nicotine results in increased expression of CHRNA5 mRNA; Nicotine results in increased expression of CHRNA5 protein CHRNA5 gene polymorphism affects the susceptibility to Nicotine |
CTD |
PMID:9495872 PMID:12628473 PMID:18450646 PMID:18519132 PMID:24793809 PMID:29293602 PMID:29486207 PMID:35131329 More...
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NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146
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G |
Chrna6 |
cholinergic receptor nicotinic alpha 6 subunit |
decreases expression affects response to substance multiple interactions increases expression affects binding |
ISO EXP |
Nicotine results in decreased expression of CHRNA6 mRNA CHRNA6 gene polymorphism affects the susceptibility to Nicotine Nicotine inhibits the reaction [[CHRNA6 protein binds to CHRNB2 protein] which results in increased secretion of Dopamine]; Nicotine inhibits the reaction [Paraquat results in decreased expression of [CHRNA6 protein binds to CHRNB2 protein]] Nicotine results in increased expression of CHRNA6 mRNA nicotine inhibits the reaction [alpha-Conotoxin MII binds to Chrna6]; nicotine inhibits the reaction [epibatidine binds to Chrna6]. nicotine binds to Chrna6 protein |
CTD RGD |
PMID:10734154 PMID:12628473 PMID:17227438 PMID:29293602 PMID:30959089 PMID:22550286 PMID:22550286 More...
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RGD:8549526, RGD:8549526 |
NCBI chr16:64,697,741...64,704,441
Ensembl chr16:64,697,741...64,704,441
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G |
Chrna7 |
cholinergic receptor nicotinic alpha 7 subunit |
increases response to substance multiple interactions decreases expression increases activity increases expression affects response to substance affects activity affects binding |
ISO EXP |
CHRNA7 protein mutant form results in increased susceptibility to Nicotine 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]; 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [Nicotine affects the activity of CHRNA7 protein]; 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [Nicotine results in increased activity of CHRNA7 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]; [GATA4 co-treated with GATA6] affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased abundance of Epinephrine]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of DBH mRNA]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of TH mRNA]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; [Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium; Bungarotoxins inhibits the reaction [Nicotine binds to and results in increased activity of CHRNA7 protein]; Bungarotoxins inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein]; CHRNA7 affects the reaction [Nicotine results in decreased expression of SLBP protein]; CHRNA7 affects the reaction [Nicotine results in increased expression of CDK1 protein]; CHRNA7 affects the reaction [Nicotine results in increased expression of CSNK2A1 protein]; CHRNA7 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; CHRNA7 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 mRNA]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 protein]; GATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; GATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein]; KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]; MB327 analog promotes the reaction [Nicotine affects the activity of CHRNA7 protein]; MB327 promotes the reaction [Nicotine affects the activity of CHRNA7 protein]; MB327 promotes the reaction [Nicotine results in increased activity of CHRNA7 protein]; methyllycaconitine inhibits the reaction [Nicotine binds to and results in increased activity of CHRNA7 protein]; methyllycaconitine promotes the reaction [[Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium]; Nicotine binds to and results in increased activity of CHRNA7 protein; Nicotine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]; Nicotine promotes the reaction [[GATA4 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [[GATA6 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [GATA6 protein binds to GATA4 protein binds to SP1 protein binds to CHRNA7 promoter]; Nicotine results in increased expression of and results in increased phosphorylation of CHRNA7 protein; Pyridinium Compounds analog promotes the reaction [Nicotine results in increased activity of CHRNA7 protein] Nicotine results in decreased expression of CHRNA7 mRNA Nicotine results in increased expression of CHRNA7; Nicotine results in increased expression of CHRNA7 mRNA; Nicotine results in increased expression of CHRNA7 protein CHRNA7 gene polymorphism affects the susceptibility to Nicotine; CHRNA7 protein affects the susceptibility to Nicotine [Bungarotoxins results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine; [triethyl-(beta-4-stilbenoxyethyl)ammonium results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which affects the susceptibility to Nicotine; [Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of CHRNA7 protein; [Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium; Nicotine inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]; Nicotine inhibits the reaction [methyllycaconitine binds to CHRNA7 protein]; Nicotine results in increased expression of and results in increased phosphorylation of CHRNA7 protein Nicotine results in decreased expression of CHRNA7 mRNA; Nicotine results in decreased expression of CHRNA7 protein nicotine affects binding of the neuronal nicotinic acetylcholine receptor Chrna7 in rat hippocampal neurons |
CTD RGD |
PMID:9336329 PMID:9495872 PMID:10082212 PMID:10216184 PMID:10942032 PMID:11854451 PMID:11893908 PMID:12626641 PMID:12628473 PMID:14500745 PMID:16862215 PMID:17135361 PMID:17151781 PMID:17218065 PMID:17241116 PMID:17459420 PMID:17498763 PMID:17709503 PMID:18385335 PMID:18448488 PMID:18450646 PMID:19448648 PMID:20060465 PMID:20106947 PMID:24089524 PMID:24380835 PMID:27329243 PMID:29191791 PMID:29248576 PMID:29293602 PMID:29501575 PMID:30959089 PMID:31622651 PMID:31846720 PMID:34628512 PMID:35929799 PMID:15801858 More...
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RGD:1600992 |
NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240
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G |
Chrna9 |
cholinergic receptor nicotinic alpha 9 subunit |
increases expression multiple interactions |
ISO |
Nicotine results in increased expression of CHRNA9 mRNA [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of CHRNA9 protein |
CTD |
PMID:29486207 PMID:30259641 PMID:30959089 PMID:31846720 |
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NCBI chr14:42,235,218...42,241,939
Ensembl chr14:42,235,226...42,242,192
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G |
Chrnb2 |
cholinergic receptor nicotinic beta 2 subunit |
multiple interactions affects binding increases expression affects response to substance decreases expression |
ISO EXP |
[CHRNA4 protein binds to CHRNB2 protein] which results in increased susceptibility to Nicotine; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Nicotine inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Nicotine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein] Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein] CHRNB2 promotes the reaction [Nicotine results in increased expression of RYR2 mRNA]; cytisine inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]; Hexamethonium inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]; Nicotine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine inhibits the reaction [[CHRNA6 protein binds to CHRNB2 protein] which results in increased secretion of Dopamine]; Nicotine inhibits the reaction [Paraquat results in decreased expression of [CHRNA6 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein] Nicotine results in increased expression of CHRNB2 mRNA CHRNB2 protein affects the susceptibility to Nicotine Nicotine results in increased expression of CHRNB2 mRNA; Nicotine results in increased expression of CHRNB2 protein Nicotine analog binds to [CHRNA4 protein binds to CHRNB2 protein]; Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein] Nicotine results in decreased expression of CHRNB2 mRNA 1-(5-azido-6-chloropyridin-3-ylmethyl)-2-nitroiminoimidazolidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine; [Nicotine co-treated with Benzo(a)pyrene] results in decreased expression of [CHRNA4 protein binds to CHRNB2 protein]; Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; imidacloprid analog inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; N-(5-azido-6-chloropyridin-3-ylmethyl)-N'-methyl-N''-nitroguanidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein]; Nicotine results in increased expression of [CHRNA4 protein binds to CHRNB2 protein] nicotine affects binding to Chrnb2 protein; nicotine competes with [Epibatidine binds to Chrnb2 protein] nicotine affects binding to Chrnb2 protein; nicotine inhibits the reaction [epibatidine affects binding to Chrnb2 protein] in rat retina |
CTD RGD |
PMID:7756618 PMID:9336329 PMID:10336510 PMID:10377228 PMID:10945867 PMID:11124396 PMID:11150171 PMID:14645658 PMID:14982698 PMID:15615518 PMID:16915382 PMID:16981889 PMID:17227438 PMID:18448488 PMID:19252481 PMID:19481067 PMID:20060465 PMID:20457658 PMID:20943775 PMID:21113126 PMID:28555334 PMID:29293602 PMID:29486207 PMID:30247698 PMID:31846720 PMID:34628512 PMID:15016836 PMID:16129735 More...
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RGD:2303194, RGD:2303195 |
NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
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G |
Chrnb3 |
cholinergic receptor nicotinic beta 3 subunit |
increases expression multiple interactions |
EXP |
Nicotine results in increased expression of CHRNB3 mRNA nicotine affects binding to Chrnb3 protein; nicotine inhibits the reaction [epibatidine affects binding to Chrnb3 protein] in rat retina |
CTD RGD |
PMID:30959089 PMID:16129735 |
RGD:2303195 |
NCBI chr16:64,713,438...64,751,360
Ensembl chr16:64,714,169...64,751,360
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G |
Chrnb4 |
cholinergic receptor nicotinic beta 4 subunit |
multiple interactions affects response to substance increases activity increases expression |
ISO EXP |
Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein] CHRNB4 protein affects the susceptibility to Nicotine Nicotine analog binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein] Nicotine results in increased activity of CHRNB4 protein Nicotine results in increased expression of CHRNB4 mRNA |
CTD |
PMID:9454827 PMID:11600638 PMID:15275829 PMID:15615518 PMID:19483072 PMID:29293602 PMID:34628512 More...
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NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027
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G |
Ciao1 |
cytosolic iron-sulfur assembly component 1 |
decreases expression |
EXP |
Nicotine results in decreased expression of CIAO1 mRNA |
CTD |
PMID:11478936 |
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NCBI chr 3:114,458,671...114,465,928
Ensembl chr 3:114,458,655...114,467,009
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G |
Cib1 |
calcium and integrin binding 1 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CIB1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CIB1 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 1:134,178,331...134,183,895
Ensembl chr 1:134,178,331...134,213,423
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G |
Cidea |
cell death-inducing DFFA-like effector a |
decreases expression |
EXP |
Nicotine results in decreased expression of CIDEA mRNA |
CTD |
PMID:33091441 |
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NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481
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G |
Cirbp |
cold inducible RNA binding protein |
increases expression |
ISO |
Nicotine results in increased expression of CIRBP mRNA |
CTD |
PMID:21955143 |
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NCBI chr 7:9,533,857...9,538,899
Ensembl chr 7:9,424,178...9,538,818
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G |
Ckmt1 |
creatine kinase, mitochondrial 1 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CKMT1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CKMT1 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 3:108,329,859...108,335,760
Ensembl chr 3:108,330,705...108,335,758
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G |
Ckmt2 |
creatine kinase, mitochondrial 2 |
decreases expression |
ISO |
Nicotine results in decreased expression of CKMT2 mRNA |
CTD |
PMID:16949557 |
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NCBI chr 2:23,079,918...23,110,518
Ensembl chr 2:23,079,918...23,110,430
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G |
Cks1b |
CDC28 protein kinase regulatory subunit 1B |
decreases expression |
ISO |
Nicotine results in decreased expression of CKS1B mRNA |
CTD |
PMID:18247414 |
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NCBI chr 2:174,833,025...174,837,614
Ensembl chr 2:174,833,050...174,837,636
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G |
Cks2 |
CDC28 protein kinase regulatory subunit 2 |
increases expression |
ISO |
Nicotine results in increased expression of CKS2 mRNA |
CTD |
PMID:16949557 |
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NCBI chr17:13,570,611...13,575,770
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G |
Clca2 |
chloride channel accessory 2 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CLCA2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CLCA2 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 2:233,993,619...234,022,691
Ensembl chr 2:233,995,078...234,022,199
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G |
Clcc1 |
chloride channel CLIC-like 1 |
increases expression |
ISO |
Nicotine results in increased expression of CLCC1 mRNA |
CTD |
PMID:16949557 |
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NCBI chr 2:196,296,350...196,326,914
Ensembl chr 2:196,296,393...196,326,913
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G |
Clcn3 |
chloride voltage-gated channel 3 |
increases expression |
ISO |
Nicotine results in increased expression of CLCN3 mRNA |
CTD |
PMID:16949557 |
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NCBI chr16:29,127,152...29,200,133
Ensembl chr16:29,127,419...29,200,119
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G |
Cldn4 |
claudin 4 |
decreases expression increases expression |
ISO |
Nicotine results in decreased expression of CLDN4 protein Nicotine results in increased expression of CLDN4 protein |
CTD |
PMID:31783125 |
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NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436
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G |
Clic1 |
chloride intracellular channel 1 |
decreases expression |
ISO |
Nicotine results in decreased expression of CLIC1 mRNA |
CTD |
PMID:16949557 |
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NCBI chr20:3,764,867...3,773,711
Ensembl chr20:3,761,461...3,773,712
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G |
Clmp |
CXADR-like membrane protein |
increases expression |
ISO |
Nicotine results in increased expression of CLMP mRNA |
CTD |
PMID:23825647 |
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NCBI chr 8:41,060,527...41,168,841
Ensembl chr 8:41,060,799...41,168,838
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G |
Clstn1 |
calsyntenin 1 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CLSTN1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CLSTN1 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 5:160,031,235...160,094,585
Ensembl chr 5:160,031,308...160,094,583
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G |
Cmtm5 |
CKLF-like MARVEL transmembrane domain containing 5 |
decreases expression |
ISO |
Nicotine results in decreased expression of CMTM5 mRNA |
CTD |
PMID:21955143 |
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NCBI chr15:28,412,624...28,415,304
Ensembl chr15:28,412,624...28,415,287
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G |
Cnn2 |
calponin 2 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CNN2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CNN2 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 7:9,712,505...9,719,678
Ensembl chr 7:9,712,516...9,719,656
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G |
Cnr1 |
cannabinoid receptor 1 |
affects response to substance multiple interactions increases expression |
ISO |
CNR1 protein affects the susceptibility to Nicotine [rimonabant binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to Nicotine Nicotine results in increased expression of CNR1 mRNA |
CTD |
PMID:12384171 PMID:16416159 PMID:21955143 |
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NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
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G |
Cntn1 |
contactin 1 |
multiple interactions decreases expression increases expression |
ISO |
alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]; alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA] |
CTD |
PMID:12588870 PMID:16949557 |
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NCBI chr 7:123,263,146...123,560,896
Ensembl chr 7:123,372,792...123,558,541
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions increases expression |
ISO EXP |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COL1A1 mRNA; NGF protein affects the reaction [Nicotine results in increased expression of COL1A1 mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of COL1A1 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]; Nicotine promotes the reaction [Thioacetamide results in increased expression of COL1A1] Nicotine results in increased expression of COL1A1 mRNA; Nicotine results in increased expression of COL1A1 protein |
CTD |
PMID:20230807 PMID:28440100 PMID:33082140 PMID:33640489 PMID:34153408 |
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NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Col1a2 |
collagen type I alpha 2 chain |
multiple interactions |
EXP ISO |
Nicotine promotes the reaction [Arginine results in increased expression of COL1A2 protein] Nicotine promotes the reaction [Quartz results in increased expression of COL1A2 protein] |
CTD |
PMID:34153408 PMID:36868510 |
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NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
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G |
Col2a1 |
collagen type II alpha 1 chain |
decreases expression multiple interactions |
EXP ISO |
Nicotine results in decreased expression of COL2A1 mRNA; Nicotine results in decreased expression of COL2A1 protein NLRP3 protein affects the reaction [Nicotine results in decreased expression of COL2A1 mRNA] |
CTD |
PMID:29660438 PMID:31299270 PMID:34245815 PMID:39098741 |
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NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
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G |
Col3a1 |
collagen type III alpha 1 chain |
increases expression multiple interactions |
ISO EXP |
Nicotine results in increased expression of COL3A1 mRNA NGF protein affects the reaction [Nicotine results in increased expression of COL3A1 mRNA] Nicotine results in increased expression of COL3A1 mRNA; Nicotine results in increased expression of COL3A1 protein Nicotine promotes the reaction [Arginine results in increased expression of COL3A1 protein] |
CTD |
PMID:33082140 PMID:34153408 |
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NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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G |
Col6a1 |
collagen type VI alpha 1 chain |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COL6A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of COL6A1 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597
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G |
Cort |
cortistatin |
affects expression decreases expression |
EXP |
Nicotine affects the expression of CORT protein Nicotine results in decreased expression of CORT protein |
CTD |
PMID:22975262 PMID:26776438 PMID:28555334 |
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NCBI chr 5:159,560,591...159,562,032
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G |
Cox7a2l |
cytochrome c oxidase subunit 7A2 like |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of COX7A2L mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of COX7A2L mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 6:11,184,064...11,198,287
Ensembl chr 6:11,184,285...11,198,273
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G |
Cox7c |
cytochrome c oxidase subunit 7C |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COX7C mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of COX7C mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 2:16,841,771...16,843,796
Ensembl chr 2:16,840,837...16,843,760
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G |
Crabp2 |
cellular retinoic acid binding protein 2 |
decreases expression |
ISO |
Nicotine results in decreased expression of CRABP2 mRNA |
CTD |
PMID:16949557 |
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NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379
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G |
Crct1 |
cysteine-rich C-terminal 1 |
increases expression |
ISO |
Nicotine results in increased expression of CRCT1 mRNA |
CTD |
PMID:23825647 |
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NCBI chr 2:178,633,789...178,635,274
Ensembl chr 2:178,634,092...178,634,394
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions decreases expression increases phosphorylation increases expression |
ISO EXP |
CREB1 protein promotes the reaction [Nicotine results in increased expression of MMP7 mRNA] Nicotine results in decreased expression of CREB1 mRNA Nicotine results in increased phosphorylation of CREB1 protein CREB1 protein promotes the reaction [Nicotine results in increased expression of RYR2 mRNA]; Excitatory Amino Acid Antagonists inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]; KN 93 inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]; Mecamylamine inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]; Nicotine promotes the reaction [CREB1 protein modified form binds to RYR2 promoter]; Nifedipine inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]; Ryanodine inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein] Nicotine results in increased expression of CREB1 mRNA |
CTD |
PMID:18247414 PMID:21113126 PMID:25847246 PMID:31945395 |
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NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Creb3 |
cAMP responsive element binding protein 3 |
increases expression |
ISO |
Nicotine results in increased expression of CREB3 mRNA |
CTD |
PMID:31945395 |
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NCBI chr 5:57,817,865...57,823,233
Ensembl chr 5:57,817,832...57,824,390
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G |
Creb5 |
cAMP responsive element binding protein 5 |
increases expression |
ISO |
Nicotine results in increased expression of CREB5 mRNA |
CTD |
PMID:31945395 |
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NCBI chr 4:82,393,091...82,794,320
Ensembl chr 4:82,393,730...82,790,325
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G |
Crebbp |
CREB binding protein |
increases expression |
ISO |
Nicotine results in increased expression of CREBBP mRNA |
CTD |
PMID:31945395 |
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NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
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G |
Crh |
corticotropin releasing hormone |
decreases expression increases expression |
EXP ISO |
Nicotine results in decreased expression of CRH mRNA; Nicotine results in decreased expression of CRH protein Nicotine results in increased expression of CRH protein |
CTD |
PMID:21955143 PMID:22265867 PMID:23623838 PMID:28555334 |
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NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
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G |
Cryab |
crystallin, alpha B |
decreases expression |
ISO |
Nicotine results in decreased expression of CRYAB mRNA |
CTD |
PMID:21955143 |
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NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
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G |
Cs |
citrate synthase |
multiple interactions |
ISO |
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of CS mRNA |
CTD |
PMID:33091441 |
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NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
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G |
Csdc2 |
cold shock domain containing C2 |
decreases expression |
ISO |
Nicotine results in decreased expression of CSDC2 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 7:113,451,998...113,466,464
Ensembl chr 7:113,451,998...113,466,463
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G |
Csf2 |
colony stimulating factor 2 |
multiple interactions increases secretion |
ISO |
Nicotine results in increased expression of and results in increased secretion of CSF2 protein; Tubocurarine inhibits the reaction [Nicotine results in increased secretion of CSF2 protein] |
CTD |
PMID:9606035 PMID:18082304 |
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NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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G |
Csn2 |
casein beta |
multiple interactions |
ISO |
Nicotine results in decreased expression of and results in decreased secretion of CSN2 protein |
CTD |
PMID:31783125 |
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NCBI chr14:20,322,581...20,329,818
Ensembl chr14:20,322,581...20,329,817
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G |
Csnk2a1 |
casein kinase 2 alpha 1 |
multiple interactions increases expression |
ISO |
CHRNA7 affects the reaction [Nicotine results in increased expression of CSNK2A1 protein]; CSNK2A1 affects the reaction [Nicotine results in decreased expression of SLBP protein]; CSNK2A1 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:35929799 |
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NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696
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G |
Cst3 |
cystatin C |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CST3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CST3 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822
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G |
Ctnnb1 |
catenin beta 1 |
multiple interactions increases expression |
ISO |
Carbon Tetrachloride inhibits the reaction [Nicotine results in decreased expression of CTNNB1 mRNA]; Nicotine inhibits the reaction [Carbon Tetrachloride results in decreased expression of CTNNB1 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of CTNNB1 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of CTNNB1 protein] Nicotine results in increased expression of CTNNB1 mRNA; Nicotine results in increased expression of CTNNB1 protein |
CTD |
PMID:33640489 PMID:35411647 |
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NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Ctsb |
cathepsin B |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CTSB mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CTSB mRNA] |
CTD |
PMID:20230807 |
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NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
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G |
Ctsh |
cathepsin H |
increases expression |
ISO |
Nicotine results in increased expression of CTSH mRNA |
CTD |
PMID:23825647 |
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NCBI chr 8:90,608,941...90,627,824
Ensembl chr 8:90,608,941...90,627,824
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G |
Ctsl |
cathepsin L |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CTSL mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CTSL mRNA] |
CTD |
PMID:20230807 |
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NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
decreases expression |
ISO |
Nicotine results in decreased expression of CXCL2 mRNA |
CTD |
PMID:18247414 |
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NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
decreases expression increases expression decreases secretion |
ISO |
Nicotine results in decreased expression of CXCL1 mRNA Nicotine results in increased expression of CXCL1 protein Nicotine results in decreased secretion of CXCL1 protein |
CTD |
PMID:16254210 PMID:22093924 |
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NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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G |
Cxcr2 |
C-X-C motif chemokine receptor 2 |
decreases expression increases expression |
ISO |
Nicotine results in decreased expression of CXCR2 mRNA Nicotine results in increased expression of CXCR2 mRNA |
CTD |
PMID:18247414 PMID:20457658 |
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NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
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G |
Cxcr3 |
C-X-C motif chemokine receptor 3 |
increases expression |
ISO |
Nicotine results in increased expression of CXCR3 mRNA |
CTD |
PMID:20457658 |
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NCBI chr X:66,844,318...66,846,969
Ensembl chr X:66,844,318...66,846,969
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G |
Cxcr4 |
C-X-C motif chemokine receptor 4 |
multiple interactions increases expression |
ISO |
[Mecamylamine co-treated with Dihydro-beta-Erythroidine co-treated with Bungarotoxins] inhibits the reaction [Nicotine results in increased expression of CXCR4 protein] Nicotine results in increased expression of CXCR4 mRNA; Nicotine results in increased expression of CXCR4 protein |
CTD |
PMID:20457658 |
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NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
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G |
Cycs |
cytochrome c, somatic |
multiple interactions decreases secretion affects localization increases secretion increases expression |
ISO EXP |
Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium affects the localization of CYCS protein] Nicotine results in decreased secretion of CYCS protein Nicotine affects the localization of CYCS protein Folic Acid inhibits the reaction [Nicotine results in increased expression of CYCS protein]; Nicotine inhibits the reaction [[Calcium co-treated with Phosphates] affects the localization of CYCS protein] Nicotine results in increased secretion of CYCS protein |
CTD |
PMID:11701223 PMID:15985439 PMID:18203686 PMID:29972271 |
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NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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G |
Cyp11a1 |
cytochrome P450, family 11, subfamily a, polypeptide 1 |
decreases expression multiple interactions decreases activity |
ISO EXP |
Nicotine results in decreased expression of CYP11A1 mRNA; Nicotine results in decreased expression of CYP11A1 protein [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CYP11A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP11A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 protein] Nicotine results in decreased activity of CYP11A1 protein |
CTD |
PMID:20230807 PMID:21971485 PMID:22265867 PMID:24709674 PMID:28986172 PMID:30959089 PMID:31846720 More...
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NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
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G |
Cyp11b2 |
cytochrome P450, family 11, subfamily b, polypeptide 2 |
decreases expression |
EXP |
Nicotine results in decreased expression of CYP11B1 mRNA |
CTD |
PMID:24709674 |
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NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004
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G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
decreases expression |
ISO EXP |
Nicotine results in decreased expression of CYP17A1 mRNA Nicotine results in decreased expression of CYP17A1 mRNA; Nicotine results in decreased expression of CYP17A1 protein |
CTD |
PMID:24709674 PMID:27782041 PMID:28986172 |
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NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
decreases expression multiple interactions increases activity |
EXP ISO |
Nicotine results in decreased expression of CYP19A1 mRNA; Nicotine results in decreased expression of CYP19A1 protein Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 protein] Nicotine results in increased activity of CYP19A1 protein |
CTD |
PMID:30959089 PMID:32113805 |
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NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression multiple interactions |
ISO |
Nicotine results in increased expression of CYP1A1 mRNA; Nicotine results in increased expression of CYP1A1 protein 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CYP1A1 protein]; CYP1A1 protein affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; diphenyleneiodonium inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]; SB 203580 inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]; SR 11302 inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA] |
CTD |
PMID:11849738 PMID:22498344 PMID:34171359 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression decreases activity decreases expression |
ISO EXP |
Nicotine results in increased expression of CYP1A2 protein Nicotine results in decreased activity of CYP1A2 protein Nicotine results in decreased expression of CYP1A2 mRNA |
CTD |
PMID:11849738 PMID:15916432 PMID:26463278 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp26a1 |
cytochrome P450, family 26, subfamily a, polypeptide 1 |
decreases expression |
ISO |
Nicotine results in decreased expression of CYP26A1 mRNA; Nicotine results in decreased expression of CYP26A1 protein |
CTD |
PMID:21371177 |
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NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
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G |
Cyp2a1 |
cytochrome P450, family 2, subfamily a, polypeptide 1 |
increases expression increases metabolic processing decreases activity multiple interactions |
EXP ISO |
Nicotine results in increased expression of CYP2A1 mRNA CYP2A13 protein results in increased metabolism of Nicotine Nicotine results in decreased activity of CYP2A13 protein Nicotine inhibits the reaction [[CYP2A13 protein results in increased metabolism of N'-nitrosonornicotine] which results in increased abundance of 4-hydroxy-1-(3-pyridyl)-1-butanone]; Nicotine inhibits the reaction [CYP2A13 protein results in increased susceptibility to Aflatoxin B1] |
CTD |
PMID:22743290 PMID:22934830 PMID:27567546 |
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NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
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G |
Cyp2a2 |
cytochrome P450, family 2, subfamily a, polypeptide 2 |
increases expression increases hydroxylation |
EXP |
Nicotine results in increased expression of CYP2A2 mRNA CYP2A6 protein results in increased hydroxylation of Nicotine |
CTD |
PMID:12919726 PMID:22934830 |
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NCBI chr 1:82,263,833...82,289,487
Ensembl chr 1:82,263,833...82,289,487
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G |
Cyp2a3 |
cytochrome P450, family 2, subfamily a, polypeptide 3 |
increases expression |
EXP |
Nicotine results in increased expression of CYP2A3 mRNA |
CTD |
PMID:14972772 PMID:22934830 |
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NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
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G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
increases metabolic processing increases expression multiple interactions |
EXP |
CYP2B1 protein results in increased metabolism of Nicotine Nicotine results in increased expression of CYP2B1 mRNA; Nicotine results in increased expression of CYP2B1 protein [Nicotine co-treated with 2,2',3,5',6-pentachlorobiphenyl] results in increased expression of CYP2B1 mRNA; [Nicotine results in increased expression of CYP2B1 protein] which results in increased abundance of Cotinine; [Nicotine results in increased expression of CYP2B1 protein] which results in increased metabolism of Nicotine; Nicotine results in increased expression of and results in increased activity of CYP2B1 protein |
CTD |
PMID:10799646 PMID:14972772 PMID:20599831 PMID:26463278 |
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NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
increases metabolic processing multiple interactions increases oxidation affects oxidation |
ISO |
CYP2B6 protein results in increased metabolism of Nicotine CYP2B6 gene polymorphism affects the reaction [CYP2A6 protein results in increased metabolism of Nicotine] CYP2B6 protein results in increased oxidation of Nicotine CYP2B6 gene polymorphism affects the oxidation of Nicotine |
CTD |
PMID:12488541 PMID:18004205 PMID:30906561 |
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NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
multiple interactions increases expression |
ISO |
Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA]]; Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 protein]]; Ketoconazole inhibits the reaction [Nicotine results in increased expression of CYP2D22 mRNA]; Ketoconazole inhibits the reaction [Nicotine results in increased expression of CYP2D22 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 protein]; Nicotine inhibits the reaction [Ketoconazole results in decreased expression of CYP2D22 mRNA]; Nicotine inhibits the reaction [Ketoconazole results in decreased expression of CYP2D22 protein] Nicotine results in increased expression of CYP2D22 mRNA; Nicotine results in increased expression of CYP2D22 protein |
CTD |
PMID:19594327 |
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NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
increases expression |
EXP |
Nicotine results in increased expression of CYP2E1 protein |
CTD |
PMID:16434548 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions |
EXP ISO |
[Nicotine co-treated with 2,2',3,5',6-pentachlorobiphenyl] results in increased expression of CYP3A2 mRNA [Nicotine binds to CYP3A4 promoter] which results in increased expression of CYP3A4 mRNA |
CTD |
PMID:12851153 PMID:26463278 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp4f18 |
cytochrome P450, family 4, subfamily f, polypeptide 18 |
increases expression |
ISO |
Nicotine results in increased expression of CYP4F3 mRNA |
CTD |
PMID:23825647 |
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NCBI chr16:17,763,543...17,804,944
Ensembl chr16:17,707,317...17,804,940
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G |
Dbh |
dopamine beta-hydroxylase |
multiple interactions increases expression |
ISO |
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of DBH mRNA] |
CTD |
PMID:17498763 |
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NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
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G |
Dbi |
diazepam binding inhibitor |
increases expression |
ISO |
nicotine increases expression of Dbi mRNA and protein in cerebral cortex and cortical neurons. |
RGD |
PMID:11750077 |
RGD:408356485 |
NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693
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G |
Dcaf16 |
DDB1 and CUL4 associated factor 16 |
increases expression |
ISO |
Nicotine results in increased expression of DCAF16 mRNA |
CTD |
PMID:16949557 |
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NCBI chr14:65,449,631...65,450,015
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G |
Ddb1 |
damage-specific DNA binding protein 1 |
decreases expression |
ISO |
Nicotine results in decreased expression of DDB1 mRNA |
CTD |
PMID:16949557 |
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NCBI chr 1:207,252,890...207,278,685
Ensembl chr 1:207,252,890...207,278,676
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G |
Ddhd2 |
DDHD domain containing 2 |
multiple interactions |
ISO |
[Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of DDHD2 mRNA |
CTD |
PMID:28065790 |
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NCBI chr16:66,319,469...66,349,025
Ensembl chr16:66,319,466...66,349,023
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions |
ISO EXP |
Nicotine inhibits the reaction [Cisplatin results in increased expression of DDIT3 mRNA] Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DDIT3 protein] Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of DDIT3 protein] |
CTD |
PMID:11592233 PMID:28082123 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Ddit4 |
DNA-damage-inducible transcript 4 |
increases expression |
ISO |
Nicotine results in increased expression of DDIT4 mRNA |
CTD |
PMID:17456735 PMID:23825647 |
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NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
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G |
Ddx17 |
DEAD-box helicase 17 |
increases expression |
ISO |
Nicotine results in increased expression of DDX17 mRNA |
CTD |
PMID:16949557 |
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NCBI chr 7:111,091,127...111,109,353
Ensembl chr 7:111,089,445...111,109,193
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G |
Dedd |
death effector domain-containing |
decreases expression |
ISO |
Nicotine results in decreased expression of DEDD mRNA |
CTD |
PMID:18247414 |
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NCBI chr13:83,755,874...83,769,982
Ensembl chr13:83,756,108...83,769,332
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G |
Defb23 |
defensin beta 23 |
decreases expression |
ISO |
Nicotine results in decreased expression of DEFB129 mRNA |
CTD |
PMID:23825647 |
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NCBI chr 3:140,923,474...140,927,715
Ensembl chr 3:140,923,474...140,927,686
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G |
Dffb |
DNA fragmentation factor subunit beta |
decreases expression |
ISO |
Nicotine results in decreased expression of DFFB mRNA |
CTD |
PMID:18247414 |
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NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628
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G |
Dhcr24 |
24-dehydrocholesterol reductase |
decreases expression |
ISO |
Nicotine results in decreased expression of DHCR24 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137
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G |
Dhfr |
dihydrofolate reductase |
multiple interactions decreases expression |
ISO |
alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA] |
CTD |
PMID:12588870 |
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NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
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G |
Dhps |
deoxyhypusine synthase |
decreases expression |
ISO |
Nicotine results in decreased expression of DHPS mRNA |
CTD |
PMID:16949557 |
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NCBI chr19:23,082,454...23,086,544
Ensembl chr19:23,082,448...23,086,881
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G |
Dhrs3 |
dehydrogenase/reductase 3 |
increases expression |
ISO |
Nicotine results in increased expression of DHRS3 mRNA |
CTD |
PMID:23825647 |
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NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417
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G |
Dhx36 |
DEAH-box helicase 36 |
increases expression |
ISO |
Nicotine results in increased expression of DHX36 mRNA |
CTD |
PMID:17997037 |
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NCBI chr 2:146,856,469...146,894,577
Ensembl chr 2:146,856,469...146,894,572
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G |
Dlg4 |
discs large MAGUK scaffold protein 4 |
decreases expression decreases methylation |
ISO EXP |
Nicotine results in decreased expression of DLG4 mRNA Nicotine results in decreased methylation of DLG4 gene |
CTD |
PMID:21955143 PMID:28555334 PMID:32994467 |
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NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153
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G |
Dnaja1 |
DnaJ heat shock protein family (Hsp40) member A1 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DNAJA1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DNAJA1 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967
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G |
Dnajb9 |
DnaJ heat shock protein family (Hsp40) member B9 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DNAJB9 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DNAJB9 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063
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G |
Dnase2 |
deoxyribonuclease 2, lysosomal |
decreases expression |
ISO |
Nicotine results in decreased expression of DNASE2 mRNA |
CTD |
PMID:18247414 |
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NCBI chr19:23,244,656...23,247,376
Ensembl chr19:23,244,664...23,247,376
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G |
Dnm1l |
dynamin 1-like |
increases expression |
ISO |
Nicotine results in increased expression of DNM1L protein |
CTD |
PMID:21554491 |
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NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
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G |
Dnmt1 |
DNA methyltransferase 1 |
decreases expression multiple interactions |
EXP |
Nicotine results in decreased expression of DNMT1 mRNA Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in decreased expression of DNMT1 mRNA] |
CTD |
PMID:28555334 |
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NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
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G |
Dpp4 |
dipeptidylpeptidase 4 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DPP4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DPP4 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901
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G |
Drd1 |
dopamine receptor D1 |
multiple interactions decreases expression |
EXP ISO |
[SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to Nicotine Nicotine results in decreased expression of DRD1 mRNA |
CTD |
PMID:1833784 PMID:21955143 |
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NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
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G |
Drd2 |
dopamine receptor D2 |
multiple interactions decreases response to substance |
EXP |
[Raclopride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Nicotine DRD2 mRNA results in decreased susceptibility to Nicotine |
CTD |
PMID:1833784 PMID:24239691 |
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NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
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G |
Drd3 |
dopamine receptor D3 |
increases expression |
ISO |
Nicotine results in increased expression of DRD3 protein |
CTD |
PMID:31945395 |
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NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
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G |
Dtymk |
deoxythymidylate kinase |
decreases expression |
ISO |
Nicotine results in decreased expression of DTYMK mRNA |
CTD |
PMID:16949557 |
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NCBI chr 9:94,315,552...94,324,386
Ensembl chr 9:94,315,552...94,324,870
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G |
Dusp1 |
dual specificity phosphatase 1 |
increases expression |
ISO |
Nicotine results in increased expression of DUSP1 mRNA |
CTD |
PMID:17456735 |
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NCBI chr10:16,680,478...16,683,275
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G |
Dusp11 |
dual specificity phosphatase 11 |
decreases expression |
ISO |
Nicotine results in decreased expression of DUSP11 mRNA |
CTD |
PMID:17456735 |
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NCBI chr 4:118,367,673...118,385,183
Ensembl chr 4:118,368,053...118,385,181
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G |
Dusp6 |
dual specificity phosphatase 6 |
increases expression |
ISO |
Nicotine results in increased expression of DUSP6 mRNA |
CTD |
PMID:17456735 PMID:21955143 |
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NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
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G |
Dvl2 |
dishevelled segment polarity protein 2 |
decreases expression increases expression multiple interactions |
ISO |
Nicotine results in decreased expression of DVL2 mRNA Nicotine results in increased expression of DVL2 mRNA; Nicotine results in increased expression of DVL2 protein Carbon Tetrachloride promotes the reaction [Nicotine results in increased expression of DVL2 mRNA]; Carbon Tetrachloride promotes the reaction [Nicotine results in increased expression of DVL2 protein]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of DVL2 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of DVL2 protein] |
CTD |
PMID:16949557 PMID:33640489 PMID:35411647 |
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NCBI chr10:54,723,356...54,732,823
Ensembl chr10:54,723,411...54,732,820
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G |
Dync1li2 |
dynein, cytoplasmic 1 light intermediate chain 2 |
increases expression |
ISO |
Nicotine results in increased expression of DYNC1LI2 mRNA |
CTD |
PMID:16949557 |
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NCBI chr19:531,783...554,670
Ensembl chr19:531,812...554,670
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G |
E2f1 |
E2F transcription factor 1 |
multiple interactions increases expression |
ISO |
MK-886 inhibits the reaction [Nicotine results in increased expression of E2F1 protein]; Nicotine promotes the reaction [E2F1 protein binds to BIRC5 promoter]; Nicotine promotes the reaction [E2F1 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F1 protein binds to CDC6 promoter] |
CTD |
PMID:16601104 PMID:16862215 PMID:20061081 |
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NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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G |
E2f2 |
E2F transcription factor 2 |
multiple interactions |
ISO |
Nicotine promotes the reaction [E2F2 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F2 protein binds to CDC6 promoter] |
CTD |
PMID:16862215 |
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NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217
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G |
E2f3 |
E2F transcription factor 3 |
multiple interactions |
ISO |
Nicotine promotes the reaction [E2F3 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F3 protein binds to CDC6 promoter] |
CTD |
PMID:16862215 |
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NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253
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G |
E2f4 |
E2F transcription factor 4 |
multiple interactions |
ISO |
Nicotine inhibits the reaction [E2F4 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [E2F4 protein binds to CDC6 promoter] |
CTD |
PMID:16862215 |
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NCBI chr19:33,174,396...33,181,806
Ensembl chr19:33,174,410...33,181,806
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G |
E2f5 |
E2F transcription factor 5 |
multiple interactions |
ISO |
Nicotine inhibits the reaction [E2F5 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [E2F5 protein binds to CDC6 promoter] |
CTD |
PMID:16862215 |
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NCBI chr 2:86,997,331...87,012,908
Ensembl chr 2:86,997,332...87,012,990
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G |
Ebf2 |
EBF transcription factor 2 |
increases expression |
EXP |
Nicotine results in increased expression of EBF2 mRNA |
CTD |
PMID:35026373 |
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NCBI chr15:41,435,509...41,634,403
Ensembl chr15:41,435,509...41,634,403
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G |
Ecm1 |
extracellular matrix protein 1 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ECM1 mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ECM1 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 2:183,287,491...183,292,729
Ensembl chr 2:183,287,322...183,292,671
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G |
Edn1 |
endothelin 1 |
increases expression multiple interactions |
ISO |
Nicotine results in increased expression of EDN1 mRNA; Nicotine results in increased expression of EDN1 protein MIR98 mRNA inhibits the reaction [Nicotine results in increased expression of EDN1 mRNA]; NGF protein affects the reaction [Nicotine results in increased expression of EDN1 mRNA]; Rosiglitazone inhibits the reaction [Nicotine results in increased expression of EDN1 mRNA] |
CTD |
PMID:33082140 |
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NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Ednra |
endothelin receptor type A |
decreases expression |
ISO |
Nicotine results in decreased expression of EDNRA mRNA |
CTD |
PMID:18247414 |
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NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
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G |
Ednrb |
endothelin receptor type B |
increases activity |
EXP |
Nicotine results in increased activity of EDNRB protein |
CTD |
PMID:21316381 |
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NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
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G |
Eef2 |
eukaryotic translation elongation factor 2 |
increases expression multiple interactions |
ISO |
Nicotine results in increased expression of EEF2 protein modified form [Nicotine results in increased expression of UBA2 protein] which results in increased sumoylation of EEF2 protein |
CTD |
PMID:21554491 |
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NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183
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G |
Efhd1 |
EF-hand domain family, member D1 |
decreases expression |
ISO |
Nicotine results in decreased expression of EFHD1 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 9:87,938,259...87,984,917
Ensembl chr 9:87,938,284...87,984,917
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G |
Efna2 |
ephrin A2 |
increases expression |
ISO |
Nicotine results in increased expression of EFNA2 mRNA |
CTD |
PMID:23825647 |
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NCBI chr 7:9,515,635...9,528,071
Ensembl chr 7:9,516,429...9,527,061
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G |
Efnb3 |
ephrin B3 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EFNB3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EFNB3 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr10:54,274,506...54,281,951
Ensembl chr10:54,274,506...54,280,471
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G |
Egfr |
epidermal growth factor receptor |
decreases expression multiple interactions increases phosphorylation |
EXP ISO |
Nicotine results in decreased expression of EGFR mRNA AG 1879 inhibits the reaction [Nicotine results in increased phosphorylation of EGFR protein] |
CTD |
PMID:11478936 PMID:14569062 |
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NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Egr1 |
early growth response 1 |
increases expression multiple interactions decreases expression |
ISO EXP |
Nicotine results in increased expression of EGR1 mRNA; Nicotine results in increased expression of EGR1 protein [triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]]] which results in decreased expression of FGF2 mRNA; EGR1 protein inhibits the reaction [triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased secretion of FGF2 protein]]; EGR1 protein promotes the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; EGR1 protein promotes the reaction [Nicotine results in decreased expression of HSD11B2 protein]; Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased expression of EGR1 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 protein] [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EGR1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EGR1 mRNA] Nicotine results in decreased expression of EGR1 mRNA |
CTD |
PMID:17456735 PMID:17997037 PMID:20230807 PMID:21955143 PMID:22198237 PMID:29486207 PMID:31622651 More...
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NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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G |
Egr2 |
early growth response 2 |
increases expression |
ISO |
Nicotine results in increased expression of EGR2 mRNA |
CTD |
PMID:17456735 |
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NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
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G |
Egr3 |
early growth response 3 |
decreases expression |
ISO |
Nicotine results in decreased expression of EGR3 mRNA |
CTD |
PMID:21955143 |
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NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627
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G |
Eif2ak2 |
eukaryotic translation initiation factor 2-alpha kinase 2 |
increases expression |
ISO |
Nicotine results in increased expression of EIF2AK2 mRNA |
CTD |
PMID:16949557 |
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NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions increases phosphorylation |
EXP |
Mecamylamine inhibits the reaction [Nicotine results in increased phosphorylation of EIF2AK3 protein]; ursodoxicoltaurine inhibits the reaction [Nicotine results in increased phosphorylation of EIF2AK3 protein] |
CTD |
PMID:26803847 |
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NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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G |
Eif2b4 |
eukaryotic translation initiation factor 2B subunit delta |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EIF2B4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EIF2B4 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 6:25,183,177...25,188,832
Ensembl chr 6:25,183,186...25,188,829
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G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
increases phosphorylation |
EXP |
Nicotine results in increased phosphorylation of EIF2S1 protein |
CTD |
PMID:26803847 |
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NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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G |
Eif4e |
eukaryotic translation initiation factor 4E |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EIF4E mRNA; Nicotine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EIF4E mRNA] EIF4E protein affects the reaction [Nicotine results in increased expression of BCL2 protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of CCND1 protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of MYC protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of VEGFA protein]; Nicotine promotes the reaction [EIF4EBP1 protein binds to EIF4E protein] |
CTD |
PMID:20230807 PMID:30836163 |
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NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
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G |
Eif4e3 |
eukaryotic translation initiation factor 4E family member 3 |
multiple interactions |
ISO |
[nickel chloride co-treated with Nicotine] results in increased expression of EIF4E3 mRNA |
CTD |
PMID:37951547 |
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NCBI chr 4:132,258,502...132,301,808
Ensembl chr 4:132,258,502...132,301,808
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G |
Eif4ebp1 |
eukaryotic translation initiation factor 4E binding protein 1 |
multiple interactions |
ISO |
[Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of EIF4EBP1 protein; Nicotine promotes the reaction [EIF4EBP1 protein binds to EIF4E protein]; Nicotine results in increased expression of and results in increased phosphorylation of EIF4EBP1 protein |
CTD |
PMID:12511591 PMID:30836163 |
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NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
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G |
Eif5 |
eukaryotic translation initiation factor 5 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EIF5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EIF5 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 6:130,589,162...130,597,656
Ensembl chr 6:130,589,143...130,597,656
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G |
Elk1 |
ETS transcription factor ELK1 |
multiple interactions increases phosphorylation |
ISO EXP |
Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of ELK1 protein] |
CTD |
PMID:29486207 |
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NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713
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G |
Emc3 |
ER membrane protein complex subunit 3 |
decreases expression |
ISO |
Nicotine results in decreased expression of EMC3 mRNA |
CTD |
PMID:17997037 |
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NCBI chr 4:146,663,065...146,678,976
Ensembl chr 4:146,663,067...146,679,029
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G |
Emcn |
endomucin |
increases expression |
ISO |
Nicotine results in increased expression of EMCN mRNA |
CTD |
PMID:17456735 |
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NCBI chr 2:225,891,100...225,970,932
Ensembl chr 2:225,891,100...225,970,929
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G |
Eml4 |
EMAP like 4 |
multiple interactions decreases expression |
ISO |
alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of EML4 mRNA]; Mecamylamine promotes the reaction [Nicotine results in decreased expression of EML4 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of EML4 mRNA] |
CTD |
PMID:12588870 |
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NCBI chr 6:11,219,545...11,334,824
Ensembl chr 6:11,219,566...11,334,879
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G |
Emp1 |
epithelial membrane protein 1 |
increases expression |
ISO |
Nicotine results in increased expression of EMP1 mRNA |
CTD |
PMID:23825647 |
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NCBI chr 4:168,212,901...168,233,039
Ensembl chr 4:168,212,861...168,232,904
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G |
Enc1 |
ectodermal-neural cortex 1 |
decreases expression |
ISO |
Nicotine results in decreased expression of ENC1 mRNA |
CTD |
PMID:17997037 |
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NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713
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G |
Eng |
endoglin |
decreases expression |
ISO |
Nicotine results in decreased expression of ENG mRNA |
CTD |
PMID:17456735 |
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NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230
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G |
Eno1 |
enolase 1 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ENO1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ENO1 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336 Ensembl chr 3:160,719,951...160,731,336
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G |
Entpd3 |
ectonucleoside triphosphate diphosphohydrolase 3 |
increases expression |
ISO |
Nicotine results in increased expression of ENTPD3 mRNA |
CTD |
PMID:23825647 |
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NCBI chr 8:120,246,412...120,277,943
Ensembl chr 8:120,247,121...120,277,943
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G |
Epha3 |
Eph receptor A3 |
decreases expression |
ISO |
Nicotine results in decreased expression of EPHA3 mRNA |
CTD |
PMID:18247414 |
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NCBI chr11:1,138,485...1,474,102
Ensembl chr11:1,140,985...1,473,900
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G |
Ephb3 |
Eph receptor B3 |
decreases expression |
ISO |
Nicotine results in decreased expression of EPHB3 mRNA |
CTD |
PMID:18247414 |
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NCBI chr11:79,840,668...79,859,345
Ensembl chr11:79,840,668...79,859,370
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G |
Epo |
erythropoietin |
increases expression |
ISO |
Nicotine results in increased expression of EPO mRNA |
CTD |
PMID:18247414 |
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NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ERN1 mRNA; Nicotine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERN1 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
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G |
Erp44 |
endoplasmic reticulum protein 44 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ERP44 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERP44 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 5:62,516,550...62,610,762
Ensembl chr 5:62,516,551...62,610,761
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G |
Errfi1 |
ERBB receptor feedback inhibitor 1 |
increases expression |
ISO |
Nicotine results in increased expression of ERRFI1 mRNA |
CTD |
PMID:17456735 |
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NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282
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G |
Esr1 |
estrogen receptor 1 |
decreases expression |
ISO |
Nicotine results in decreased expression of ESR1 mRNA |
CTD |
PMID:27552315 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Etfa |
electron transfer flavoprotein subunit alpha |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ETFA mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ETFA mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 8:55,835,115...55,891,890
Ensembl chr 8:55,835,134...55,891,969
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G |
Etfb |
electron transfer flavoprotein subunit beta |
decreases expression |
ISO |
Nicotine results in decreased expression of ETFB mRNA |
CTD |
PMID:17997037 |
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NCBI chr 1:93,851,908...93,866,072
Ensembl chr 1:93,851,858...93,866,068
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G |
Ezr |
ezrin |
multiple interactions increases expression |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EZR mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EZR mRNA] Nicotine results in increased expression of EZR mRNA |
CTD |
PMID:18247414 PMID:20230807 |
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NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
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G |
F2 |
coagulation factor II, thrombin |
increases expression |
ISO |
Nicotine results in increased expression of F2 mRNA |
CTD |
PMID:18805435 |
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NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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G |
F2rl2 |
coagulation factor II (thrombin) receptor-like 2 |
increases expression |
EXP |
Nicotine results in increased expression of F2RL2 mRNA |
CTD |
PMID:27782041 |
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NCBI chr 2:26,972,054...26,977,098
Ensembl chr 2:26,972,054...26,977,098
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G |
F3 |
coagulation factor III, tissue factor |
increases expression |
ISO |
Nicotine results in increased expression of F3 mRNA |
CTD |
PMID:17997037 |
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NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
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G |
Fah |
fumarylacetoacetate hydrolase |
increases expression |
ISO |
Nicotine results in increased expression of FAH mRNA |
CTD |
PMID:23825647 |
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NCBI chr 1:138,548,830...138,571,599
Ensembl chr 1:138,548,834...138,571,505
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G |
Fam107a |
family with sequence similarity 107, member A |
decreases expression |
ISO |
Nicotine results in decreased expression of FAM107A mRNA |
CTD |
PMID:21955143 |
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NCBI chr15:16,608,362...16,630,398
Ensembl chr15:16,607,205...16,630,396
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G |
Fam120a |
family with sequence similarity 120 member A |
decreases expression |
ISO |
Nicotine results in decreased expression of FAM120A mRNA |
CTD |
PMID:17997037 |
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NCBI chr17:15,684,233...15,774,964
Ensembl chr17:15,684,233...15,774,964
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G |
Fam83f |
family with sequence similarity 83, member F |
increases expression |
ISO |
Nicotine results in increased expression of FAM83F mRNA |
CTD |
PMID:23825647 |
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NCBI chr 7:112,211,164...112,240,454
Ensembl chr 7:112,211,164...112,240,452
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G |
Fas |
Fas cell surface death receptor |
increases expression |
ISO EXP |
Nicotine results in increased expression of FAS mRNA; Nicotine results in increased expression of FAS protein |
CTD |
PMID:18203686 PMID:20383341 |
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Faslg |
Fas ligand |
affects expression increases expression |
EXP ISO |
Nicotine affects the expression of FASLG mRNA Nicotine results in increased expression of FASLG protein alternative form Nicotine results in increased expression of FASLG mRNA; Nicotine results in increased expression of FASLG protein |
CTD |
PMID:18203686 PMID:18247414 PMID:19896492 PMID:20383341 PMID:20426880 |
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NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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G |
Fasn |
fatty acid synthase |
increases expression multiple interactions affects expression |
EXP ISO |
Nicotine results in increased expression of FASN mRNA; Nicotine results in increased expression of FASN protein Nicotine promotes the reaction [NR1H3 protein binds to FASN promoter] Nicotine affects the expression of FASN mRNA |
CTD |
PMID:24368177 PMID:29155039 PMID:31622651 PMID:31972234 |
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NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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G |
Fat1 |
FAT atypical cadherin 1 |
increases expression |
ISO |
Nicotine results in increased expression of FAT1 mRNA |
CTD |
PMID:16949557 |
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NCBI chr16:47,177,253...47,296,261
Ensembl chr16:47,177,248...47,296,107
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G |
Fat2 |
FAT atypical cadherin 2 |
increases expression |
ISO |
Nicotine results in increased expression of FAT2 mRNA |
CTD |
PMID:23825647 |
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NCBI chr10:39,364,072...39,456,324
Ensembl chr10:39,364,073...39,456,216
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G |
Fbn1 |
fibrillin 1 |
increases expression |
ISO |
Nicotine results in increased expression of FBN1 mRNA |
CTD |
PMID:17456735 |
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NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889
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G |
Fbxl12 |
F-box and leucine-rich repeat protein 12 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of FBXL12 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of FBXL12 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 8:19,175,864...19,183,373
Ensembl chr 8:19,160,352...19,183,607
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G |
Fbxw5 |
F-box and WD repeat domain containing 5 |
decreases expression |
ISO |
Nicotine results in decreased expression of FBXW5 mRNA |
CTD |
PMID:17997037 |
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NCBI chr 3:8,322,543...8,327,092
Ensembl chr 3:8,322,543...8,327,092
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G |
Fez1 |
fasciculation and elongation protein zeta 1 |
increases expression decreases expression multiple interactions |
ISO |
Nicotine results in increased expression of FEZ1 mRNA Nicotine results in decreased expression of FEZ1 mRNA alpha-cobratoxin promotes the reaction [Nicotine results in decreased expression of FEZ1 mRNA alternative form]; Tubocurarine promotes the reaction [Nicotine results in decreased expression of FEZ1 mRNA] |
CTD |
PMID:12588870 |
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NCBI chr 8:36,544,462...36,589,684
Ensembl chr 8:36,544,535...36,589,683
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G |
Fgf2 |
fibroblast growth factor 2 |
multiple interactions increases secretion increases expression decreases expression |
ISO EXP |
[triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]]] which results in decreased expression of FGF2 mRNA; EGR1 protein inhibits the reaction [triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased secretion of FGF2 protein]]; Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased secretion of FGF2 protein] Nicotine results in increased expression of FGF2 mRNA; Nicotine results in increased expression of FGF2 protein Nicotine results in decreased expression of FGF2 protein Mecamylamine inhibits the reaction [Nicotine results in increased expression of FGF2 mRNA]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased expression of FGF2 mRNA] |
CTD |
PMID:9503263 PMID:9832142 PMID:14732461 PMID:15465631 PMID:16365874 PMID:18190895 PMID:22198237 PMID:31622651 PMID:32512034 More...
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NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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G |
Fgf7 |
fibroblast growth factor 7 |
multiple interactions |
ISO |
Nicotine promotes the reaction [Quartz results in increased expression of FGF7 protein] |
CTD |
PMID:36868510 |
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NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929
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G |
Flrt2 |
fibronectin leucine rich transmembrane protein 2 |
increases expression |
ISO |
Nicotine results in increased expression of FLRT2 mRNA |
CTD |
PMID:23825647 |
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NCBI chr 6:114,777,547...114,872,688
Ensembl chr 6:114,777,599...114,872,785
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G |
Flt3 |
Fms related receptor tyrosine kinase 3 |
decreases expression |
ISO |
Nicotine results in decreased expression of FLT3 mRNA |
CTD |
PMID:18247414 |
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NCBI chr12:7,623,930...7,699,474
Ensembl chr12:7,623,930...7,699,474
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G |
Fmo3 |
flavin containing dimethylaniline monoxygenase 3 |
increases metabolic processing |
ISO |
FMO3 protein results in increased metabolism of Nicotine |
CTD |
PMID:12504349 |
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NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028
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G |
Fn1 |
fibronectin 1 |
decreases expression increases expression multiple interactions |
ISO |
Nicotine results in decreased expression of FN1 mRNA Nicotine results in increased expression of FN1 protein Nicotine results in increased expression of FN1 mRNA; Nicotine results in increased expression of FN1 protein MIR98 mRNA inhibits the reaction [Nicotine results in increased expression of FN1 mRNA]; NGF protein affects the reaction [Nicotine results in increased expression of FN1 mRNA]; Nicotine promotes the reaction [Quartz results in increased expression of FN1 protein]; Rosiglitazone inhibits the reaction [Nicotine results in increased expression of FN1 mRNA] |
CTD |
PMID:18247414 PMID:18844224 PMID:33082140 PMID:36868510 |
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NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Folr1 |
folate receptor alpha |
increases expression |
ISO |
Nicotine results in increased expression of FOLR1 mRNA |
CTD |
PMID:19616087 |
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NCBI chr 1:156,219,460...156,238,436
Ensembl chr 1:156,219,460...156,230,667
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression multiple interactions decreases expression affects expression increases phosphorylation |
ISO EXP |
Nicotine results in increased expression of FOS; Nicotine results in increased expression of FOS mRNA; Nicotine results in increased expression of FOS protein [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of FOS protein]; SB 203580 inhibits the reaction [Nicotine results in increased phosphorylation of FOS protein]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of FOS] Nicotine results in decreased expression of FOS mRNA Acetaldehyde promotes the reaction [Nicotine results in increased expression of FOS mRNA]; Saponins inhibits the reaction [Nicotine results in increased expression of FOS protein] Nicotine deficiency affects the expression of FOS protein |
CTD |
PMID:11425648 PMID:15857624 PMID:16251992 PMID:16690037 PMID:17003101 PMID:17151781 PMID:17287824 PMID:17456735 PMID:20426880 PMID:27126842 PMID:34171359 PMID:34890707 More...
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Fosb |
FosB proto-oncogene, AP-1 transcription factor subunit |
increases expression increases expression |
ISO EXP |
Nicotine results in increased expression of FOSB mRNA Nicotine results in increased expression of FOSB protein nicotine increases expression of FosB protein in nucleus accumbens and caudate-putamen nicotine increases expression of Fosb protein in nucleus accumbens and dentate gyrus of hippocampal formation |
CTD RGD |
PMID:16949557 PMID:17324382 PMID:17456735 PMID:17468183 PMID:17333132 |
RGD:401900124, RGD:407571683 |
NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
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G |
Foxo1 |
forkhead box O1 |
multiple interactions |
ISO |
[Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of FOXO1 protein |
CTD |
PMID:12511591 |
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NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
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G |
Foxp1 |
forkhead box P1 |
decreases expression |
ISO |
Nicotine results in decreased expression of FOXP1 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258
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G |
Foxp3 |
forkhead box P3 |
decreases expression |
ISO |
Nicotine results in decreased expression of FOXP3 protein |
CTD |
PMID:31629012 |
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NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838
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G |
Fscn1 |
fascin actin-bundling protein 1 |
decreases expression |
ISO |
Nicotine results in decreased expression of SNL mRNA |
CTD |
PMID:18247414 |
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NCBI chr12:11,597,042...11,610,183
Ensembl chr12:11,597,048...11,610,211
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G |
Fshb |
follicle stimulating hormone subunit beta |
decreases expression |
EXP |
Nicotine results in decreased expression of FSHB mRNA; Nicotine results in decreased expression of FSHB protein |
CTD |
PMID:20498001 PMID:28986172 |
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NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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G |
Fxyd1 |
FXYD domain-containing ion transport regulator 1 |
increases expression |
ISO |
Nicotine results in increased expression of FXYD1 mRNA |
CTD |
PMID:17997037 |
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NCBI chr 1:86,287,163...86,291,478
Ensembl chr 1:86,287,165...86,291,278
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G |
Fxyd7 |
FXYD domain-containing ion transport regulator 7 |
decreases expression |
ISO |
Nicotine results in decreased expression of FXYD7 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 1:86,277,678...86,286,954
Ensembl chr 1:86,277,678...86,286,954
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G |
Fyn |
FYN proto-oncogene, Src family tyrosine kinase |
multiple interactions |
ISO |
LCK protein promotes the reaction [Nicotine results in increased phosphorylation of and results in increased activity of FYN protein]; Nicotine results in increased phosphorylation of and results in increased activity of FYN protein |
CTD |
PMID:17709503 |
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NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
decreases activity |
EXP |
Nicotine results in decreased activity of G6PD protein |
CTD |
PMID:20498001 |
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NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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G |
Gab1 |
GRB2-associated binding protein 1 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GAB1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GAB1 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr19:27,131,262...27,239,236
Ensembl chr19:27,131,262...27,239,236
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G |
Gabra3 |
gamma-aminobutyric acid type A receptor subunit alpha 3 |
increases expression |
EXP |
Nicotine results in increased expression of GABRA3 mRNA |
CTD |
PMID:28339662 |
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NCBI chr X:150,244,745...150,501,566
Ensembl chr X:150,261,607...150,501,559
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G |
Gabra5 |
gamma-aminobutyric acid type A receptor subunit alpha 5 |
increases expression |
EXP |
Nicotine results in increased expression of GABRA5 mRNA |
CTD |
PMID:28339662 |
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NCBI chr 1:108,268,728...108,381,670
Ensembl chr 1:108,268,776...108,380,917
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G |
Gabra6 |
gamma-aminobutyric acid type A receptor subunit alpha6 |
increases expression |
EXP |
Nicotine results in increased expression of GABRA6 mRNA |
CTD |
PMID:28339662 |
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NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769
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G |
Gabrg2 |
gamma-aminobutyric acid type A receptor subunit gamma 2 |
increases expression |
ISO |
Nicotine results in increased expression of GABRG2 mRNA |
CTD |
PMID:21955143 |
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NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346
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G |
Gad1 |
glutamate decarboxylase 1 |
increases expression multiple interactions decreases methylation |
EXP |
Nicotine results in increased expression of GAD1 mRNA; Nicotine results in increased expression of GAD1 protein Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in increased expression of GAD1 mRNA] Nicotine results in decreased methylation of GAD1 promoter |
CTD |
PMID:18312583 PMID:28555334 |
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NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
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G |
Gad2 |
glutamate decarboxylase 2 |
decreases expression |
EXP |
Nicotine results in decreased expression of GAD2 mRNA |
CTD |
PMID:28555334 |
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NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155
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G |
Gal |
galanin and GMAP prepropeptide |
decreases expression |
ISO |
Nicotine results in decreased expression of GAL mRNA |
CTD |
PMID:21955143 |
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NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959
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G |
Gale |
UDP-galactose-4-epimerase |
decreases expression |
ISO |
Nicotine results in decreased expression of GALE mRNA |
CTD |
PMID:16949557 |
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NCBI chr 5:148,193,886...148,198,392
Ensembl chr 5:148,194,791...148,198,388
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G |
Galk2 |
galactokinase 2 |
increases expression |
ISO |
Nicotine results in increased expression of GALK2 mRNA |
CTD |
PMID:17456735 |
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NCBI chr 3:113,110,057...113,243,014
Ensembl chr 3:113,110,030...113,233,306
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G |
Gap43 |
growth associated protein 43 |
multiple interactions |
ISO |
[Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 mRNA]; [Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 protein] |
CTD |
PMID:23933227 |
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NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
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G |
Gapdh |
glyceraldehyde-3-phosphate dehydrogenase |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GAPDH mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAPDH mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
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G |
Gata2 |
GATA binding protein 2 |
multiple interactions increases expression |
ISO |
5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]; 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of GATA2 protein]; Bungarotoxins inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]; Bungarotoxins inhibits the reaction [Nicotine results in increased expression of GATA2 protein]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 mRNA]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 protein]; GATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; GATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein]; manumycin inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]; manumycin inhibits the reaction [Nicotine results in increased expression of GATA2 protein]; U 0126 inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]; U 0126 inhibits the reaction [Nicotine results in increased expression of GATA2 protein] Nicotine results in increased expression of GATA2 mRNA; Nicotine results in increased expression of GATA2 protein |
CTD |
PMID:18450646 |
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NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
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G |
Gata4 |
GATA binding protein 4 |
multiple interactions |
ISO |
[GATA4 co-treated with GATA6] affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; Nicotine promotes the reaction [[GATA4 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [GATA4 protein binds to SP1 protein]; Nicotine promotes the reaction [GATA6 protein binds to GATA4 protein binds to SP1 protein binds to CHRNA7 promoter] |
CTD |
PMID:24089524 |
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NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
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G |
Gata6 |
GATA binding protein 6 |
multiple interactions |
ISO |
[GATA4 co-treated with GATA6] affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; Nicotine promotes the reaction [[GATA6 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [GATA6 protein binds to GATA4 protein binds to SP1 protein binds to CHRNA7 promoter]; Nicotine promotes the reaction [GATA6 protein binds to SP1 protein] [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GATA6 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GATA6 mRNA] |
CTD |
PMID:20230807 PMID:24089524 |
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NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532
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G |
Gatad2b |
GATA zinc finger domain containing 2B |
increases expression |
ISO |
Nicotine results in increased expression of GATAD2B mRNA |
CTD |
PMID:33640489 |
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NCBI chr 2:175,748,594...175,829,837
Ensembl chr 2:175,749,433...175,825,542
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G |
Gch1 |
GTP cyclohydrolase 1 |
increases expression |
ISO |
Nicotine results in increased expression of GCH1 mRNA |
CTD |
PMID:16949557 |
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NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GCLC mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GCLC mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gcm1 |
glial cells missing transcription factor 1 |
decreases expression |
EXP |
Nicotine results in decreased expression of GCM1 mRNA; Nicotine results in decreased expression of GCM1 protein |
CTD |
PMID:24368670 |
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NCBI chr 8:78,925,687...78,938,924
Ensembl chr 8:78,925,687...78,938,924
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G |
Gcnt2 |
glucosaminyl (N-acetyl) transferase 2 |
increases expression decreases expression |
ISO |
Nicotine results in increased expression of GCNT2 mRNA Nicotine results in decreased expression of GCNT2 mRNA |
CTD |
PMID:17997037 PMID:21955143 |
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NCBI chr17:23,796,859...23,901,625
Ensembl chr17:23,796,859...23,901,611
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G |
Gdf1 |
growth differentiation factor 1 |
increases expression |
ISO |
Nicotine results in increased expression of GDF1 mRNA |
CTD |
PMID:18247414 |
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NCBI chr16:19,097,309...19,112,519
Ensembl chr16:19,097,314...19,112,519
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G |
Gem |
GTP binding protein overexpressed in skeletal muscle |
increases expression |
ISO |
Nicotine results in increased expression of GEM mRNA |
CTD |
PMID:17456735 |
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NCBI chr 5:25,214,309...25,225,222
Ensembl chr 5:25,214,309...25,225,222
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G |
Gfap |
glial fibrillary acidic protein |
decreases expression increases expression |
ISO |
Nicotine results in decreased expression of GFAP mRNA Nicotine results in increased expression of GFAP mRNA |
CTD |
PMID:17997037 PMID:21955143 |
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NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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G |
Ggct |
gamma-glutamyl cyclotransferase |
increases splicing |
ISO |
Nicotine results in increased splicing of GGCT mRNA alternative form |
CTD |
PMID:23825647 |
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NCBI chr 4:84,122,921...84,129,327
Ensembl chr 4:84,123,118...84,129,277
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G |
Ggt1 |
gamma-glutamyltransferase 1 |
multiple interactions increases activity |
EXP |
Sodium Acetate inhibits the reaction [Nicotine results in increased activity of GGT1 protein] |
CTD |
PMID:31857090 |
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NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
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G |
Ghitm |
growth hormone inducible transmembrane protein |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GHITM mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GHITM mRNA] |
CTD |
PMID:20230807 |
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NCBI chr16:12,885,551...12,897,887
Ensembl chr16:12,885,553...12,897,879
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G |
Gja1 |
gap junction protein, alpha 1 |
increases expression |
ISO |
Nicotine results in increased expression of GJA1 mRNA; Nicotine results in increased expression of GJA1 protein |
CTD |
PMID:36720419 |
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NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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G |
Gja4 |
gap junction protein, alpha 4 |
increases expression |
EXP |
Nicotine results in increased expression of GJA4 mRNA |
CTD |
PMID:28087314 |
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NCBI chr 5:139,633,324...139,635,857
Ensembl chr 5:139,633,287...139,635,925
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G |
Gjc2 |
gap junction protein, gamma 2 |
increases expression |
ISO |
Nicotine results in increased expression of GJC2 mRNA |
CTD |
PMID:21955143 |
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NCBI chr10:43,962,642...43,971,358
Ensembl chr10:43,962,642...43,970,467
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G |
Glipr1 |
GLI pathogenesis-related 1 |
increases expression |
ISO |
Nicotine results in increased expression of GLIPR1 mRNA |
CTD |
PMID:16949557 |
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NCBI chr 7:47,487,342...47,498,974
Ensembl chr 7:47,487,345...47,498,429
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G |
Gm2a |
ganglioside GM2 activator |
increases expression increases splicing |
ISO |
Nicotine results in increased expression of GM2A mRNA Nicotine results in increased splicing of GM2A mRNA alternative form |
CTD |
PMID:23825647 |
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NCBI chr10:39,219,221...39,231,756
Ensembl chr10:39,219,243...39,231,757
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G |
Gmfb |
glia maturation factor, beta |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GMFB mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GMFB mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr15:20,069,923...20,081,005
Ensembl chr15:20,067,263...20,080,331
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G |
Gnai2 |
G protein subunit alpha i2 |
increases splicing multiple interactions |
ISO |
Nicotine results in increased splicing of GNAI2 mRNA alternative form [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GNAI2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GNAI2 mRNA] |
CTD |
PMID:20230807 PMID:23825647 |
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NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
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G |
Gng10 |
G protein subunit gamma 10 |
increases expression |
ISO |
Nicotine results in increased expression of GNG10 mRNA |
CTD |
PMID:16949557 |
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NCBI chr 5:73,856,124...73,863,017
Ensembl chr 5:73,856,164...73,863,012 Ensembl chr 5:73,856,164...73,863,012
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G |
Gng11 |
G protein subunit gamma 11 |
decreases expression |
ISO |
Nicotine results in decreased expression of GNG11 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 4:32,023,003...32,028,443
Ensembl chr 4:32,023,003...32,028,442
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G |
Gnrhr |
gonadotropin releasing hormone receptor |
decreases expression |
EXP |
Nicotine results in decreased expression of GNRHR mRNA |
CTD |
PMID:28986172 |
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NCBI chr14:21,856,871...21,874,861
Ensembl chr14:21,856,871...21,874,861
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G |
Golga4 |
golgin A4 |
multiple interactions increases expression |
ISO |
alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of GOLGA4 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of GOLGA4 mRNA] |
CTD |
PMID:16949557 |
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NCBI chr 8:118,208,200...118,285,003
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G |
Golt1b |
golgi transport 1B |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GOLT1B mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GOLT1B mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 4:175,333,056...175,346,156
Ensembl chr 4:175,333,092...175,346,153
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G |
Gosr2 |
golgi SNAP receptor complex member 2 |
multiple interactions |
ISO |
[Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of GOSR2 mRNA |
CTD |
PMID:28065790 |
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NCBI chr10:88,585,291...88,605,642
Ensembl chr10:88,586,299...88,605,625
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G |
Gpatch2 |
G patch domain containing 2 |
increases splicing |
ISO |
Nicotine results in increased splicing of GPATCH2 mRNA alternative form |
CTD |
PMID:23825647 |
|
NCBI chr13:98,784,993...98,925,696
Ensembl chr13:98,784,969...98,925,661
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G |
Gpnmb |
glycoprotein nmb |
increases expression |
ISO |
Nicotine results in increased expression of GPNMB mRNA |
CTD |
PMID:23825647 |
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NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367
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G |
Gpr50 |
G protein-coupled receptor 50 |
increases expression increases splicing |
ISO |
Nicotine results in increased expression of GPR50 mRNA Nicotine results in increased splicing of GPR50 mRNA alternative form |
CTD |
PMID:23825647 |
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NCBI chr X:149,368,900...149,373,486
Ensembl chr X:149,368,900...149,373,486
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G |
Gpr6 |
G protein-coupled receptor 6 |
increases expression |
ISO |
Nicotine results in increased expression of GPR6 mRNA |
CTD |
PMID:21955143 |
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NCBI chr20:44,489,853...44,492,624
Ensembl chr20:44,489,853...44,492,624
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G |
Gpr83 |
G protein-coupled receptor 83 |
increases expression |
EXP |
Nicotine results in increased expression of GPR83 mRNA |
CTD |
PMID:27782041 |
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NCBI chr 8:11,693,540...11,704,028
Ensembl chr 8:11,693,540...11,704,028
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G |
Gpr88 |
G-protein coupled receptor 88 |
increases expression |
ISO |
Nicotine results in increased expression of GPR88 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 2:204,191,443...204,199,576
Ensembl chr 2:204,191,427...204,199,733
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G |
Gprasp1 |
G protein-coupled receptor associated sorting protein 1 |
increases expression |
ISO |
Nicotine results in increased expression of GPRASP1 mRNA |
CTD |
PMID:17456735 |
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NCBI chr X:98,764,853...98,772,685
Ensembl chr X:98,709,841...98,772,851
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G |
Gprc5b |
G protein-coupled receptor, class C, group 5, member B |
increases expression |
ISO |
Nicotine results in increased expression of GPRC5B mRNA |
CTD |
PMID:21955143 |
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NCBI chr 1:173,316,904...173,340,933
Ensembl chr 1:173,316,907...173,340,932
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G |
Gprc5c |
G protein-coupled receptor, class C, group 5, member C |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GPRC5C mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GPRC5C mRNA] |
CTD |
PMID:20230807 |
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NCBI chr10:99,886,900...99,908,928
Ensembl chr10:99,887,077...99,908,926
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions increases expression |
ISO EXP |
Nicotine inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein] Nicotine results in increased expression of GPT protein dexpanthenol inhibits the reaction [Nicotine results in increased expression of GPT protein] |
CTD |
PMID:35411647 PMID:38229321 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gpx1 |
glutathione peroxidase 1 |
decreases expression increases expression |
ISO EXP |
Nicotine results in decreased expression of GPX1 mRNA Nicotine results in increased expression of GPX1 protein |
CTD |
PMID:16949557 PMID:18343235 |
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NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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G |
Gpx3 |
glutathione peroxidase 3 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GPX3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GPX3 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
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G |
Gramd1b |
GRAM domain containing 1B |
increases expression |
ISO |
Nicotine results in increased expression of GRAMD1B mRNA |
CTD |
PMID:23825647 |
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NCBI chr 8:40,654,492...40,893,869
Ensembl chr 8:40,659,182...40,893,925
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G |
Gria1 |
glutamate ionotropic receptor AMPA type subunit 1 |
multiple interactions |
EXP |
Nicotine inhibits the reaction [Ethanol increases phosphorylation of Gria1 protein in the prefrontal cortex, central amygdaloid nucleus] |
RGD |
PMID:27796078 |
RGD:405649737 |
NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
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G |
Grid1 |
glutamate ionotropic receptor delta type subunit 1 |
decreases methylation |
EXP |
Nicotine results in decreased methylation of GRID1 gene |
CTD |
PMID:32994467 |
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NCBI chr16:10,138,564...10,885,803
Ensembl chr16:10,138,925...10,885,808
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G |
Grid2 |
glutamate ionotropic receptor delta type subunit 2 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GRID2 mRNA; [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GRID2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRID2 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 4:92,415,019...93,892,472
Ensembl chr 4:92,415,230...93,889,355
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G |
Grik2 |
glutamate ionotropic receptor kainate type subunit 2 |
increases expression |
ISO |
Nicotine results in increased expression of GRIK2 mRNA |
CTD |
PMID:17997037 |
|
NCBI chr20:52,135,325...52,833,061
Ensembl chr20:52,133,851...52,838,375
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G |
Grm1 |
glutamate metabotropic receptor 1 |
decreases expression |
EXP |
Nicotine results in decreased expression of GRM1 mRNA |
CTD |
PMID:28339662 |
|
NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170
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G |
Grm2 |
glutamate metabotropic receptor 2 |
affects expression |
EXP |
Nicotine affects the expression of GRM2 mRNA |
CTD |
PMID:28339662 |
|
NCBI chr 8:107,280,099...107,293,159
Ensembl chr 8:107,280,099...107,293,146
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G |
Grm5 |
glutamate metabotropic receptor 5 |
increases expression |
ISO |
Nicotine results in increased expression of GRM5 mRNA |
CTD |
PMID:21955143 |
|
NCBI chr 1:141,310,069...141,884,980
Ensembl chr 1:141,312,368...141,882,274
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G |
Gsdma |
gasdermin A |
increases expression |
ISO |
Nicotine results in increased expression of GSDMA mRNA |
CTD |
PMID:23825647 |
|
NCBI chr10:83,614,336...83,639,543
Ensembl chr10:83,627,051...83,639,543
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G |
Gsk3a |
glycogen synthase kinase 3 alpha |
multiple interactions increases expression |
ISO |
[Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3A protein Nicotine results in increased expression of GSK3A mRNA Nicotine results in increased expression of and results in decreased phosphorylation of GSK3A protein |
CTD |
PMID:12511591 PMID:31945395 |
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NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions increases expression decreases expression |
ISO |
[Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3B protein Carbon Tetrachloride inhibits the reaction [Nicotine results in decreased expression of GSK3B mRNA]; Carbon Tetrachloride inhibits the reaction [Nicotine results in decreased expression of GSK3B protein]; Nicotine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GSK3B mRNA]; Nicotine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GSK3B protein]; Nicotine promotes the reaction [Carbon Tetrachloride results in decreased expression of GSK3B mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in decreased expression of GSK3B protein]; Nicotine results in increased expression of and results in decreased phosphorylation of GSK3B protein Nicotine results in increased expression of GSK3B mRNA Nicotine results in decreased expression of GSK3B mRNA; Nicotine results in decreased expression of GSK3B protein |
CTD |
PMID:12511591 PMID:31945395 PMID:33640489 PMID:35411647 |
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Gsr |
glutathione-disulfide reductase |
decreases activity |
EXP ISO |
Nicotine results in decreased activity of GSR protein |
CTD |
PMID:19778253 PMID:20498001 |
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Gsta4 |
glutathione S-transferase alpha 4 |
decreases expression increases activity increases expression |
EXP |
Nicotine results in decreased expression of GSTA4 mRNA Nicotine results in increased activity of GSTA4 protein Nicotine results in increased expression of GSTA4 mRNA |
CTD |
PMID:9774145 |
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NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182
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G |
Gstk1 |
glutathione S-transferase kappa 1 |
decreases expression |
ISO |
Nicotine results in decreased expression of GSTK1 mRNA |
CTD |
PMID:17997037 |
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NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292
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G |
Gstm2 |
glutathione S-transferase mu 2 |
decreases expression |
ISO |
Nicotine results in decreased expression of GSTM2 mRNA |
CTD |
PMID:33640489 |
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NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
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G |
Guca1a |
guanylate cyclase activator 1A |
decreases expression |
ISO |
Nicotine results in decreased expression of GUCA1A mRNA |
CTD |
PMID:16949557 |
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NCBI chr 9:13,588,988...13,598,566
Ensembl chr 9:13,588,525...13,598,565
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G |
H2ax |
H2A.X variant histone |
multiple interactions |
ISO |
Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of H2AX protein modified form] |
CTD |
PMID:23907605 |
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NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 Ensembl chr 4:44,671,786...44,673,239
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G |
H2az2 |
H2A.Z variant histone 2 |
decreases expression |
ISO |
Nicotine results in decreased expression of H2AZ2 mRNA |
CTD |
PMID:17456735 |
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NCBI chr14:81,293,304...81,312,209
Ensembl chr14:81,293,299...81,312,144 Ensembl chr 4:81,293,299...81,312,144 Ensembl chr16:81,293,299...81,312,144
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G |
H3c1 |
H3 clustered histone 1 |
increases expression |
ISO |
Nicotine results in increased expression of H3C1 protein |
CTD |
PMID:35929799 |
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NCBI chr17:41,368,379...41,368,902
Ensembl chr17:41,368,386...41,368,856 Ensembl chr17:41,368,386...41,368,856 Ensembl chr17:41,368,386...41,368,856 Ensembl chr17:41,368,386...41,368,856
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G |
Hand1 |
heart and neural crest derivatives expressed 1 |
decreases expression |
EXP ISO |
Nicotine results in decreased expression of HAND1 mRNA; Nicotine results in decreased expression of HAND1 protein |
CTD |
PMID:24368670 PMID:31507073 |
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NCBI chr10:42,006,646...42,009,213
Ensembl chr10:42,006,651...42,009,213
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G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
increases expression |
ISO |
Nicotine results in increased expression of HAVCR1 protein |
CTD |
PMID:21511693 |
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NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
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G |
Hba-a1 |
hemoglobin alpha, adult chain 1 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HBA-A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HBA-A1 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr10:15,337,265...15,338,121
Ensembl chr10:15,307,815...15,338,392
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G |
Hdac1 |
histone deacetylase 1 |
increases expression multiple interactions |
ISO EXP |
Nicotine results in increased expression of HDAC1 mRNA SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC1 mRNA]; SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC1 protein] Nicotine results in increased expression of HDAC1 mRNA; Nicotine results in increased expression of HDAC1 protein |
CTD |
PMID:24709674 PMID:34245815 |
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NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
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G |
Hdac2 |
histone deacetylase 2 |
increases expression decreases expression multiple interactions |
EXP ISO |
Nicotine results in increased expression of HDAC2 mRNA; Nicotine results in increased expression of HDAC2 protein Nicotine results in decreased expression of HDAC2 protein SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC2 mRNA]; SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC2 protein] |
CTD |
PMID:24709674 PMID:31507073 PMID:31846720 PMID:34245815 |
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NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609
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G |
Hdac4 |
histone deacetylase 4 |
multiple interactions increases expression |
ISO EXP |
Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 protein] Nicotine results in increased expression of HDAC4 mRNA; Nicotine results in increased expression of HDAC4 protein |
CTD |
PMID:31846720 |
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NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164
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G |
Hdac7 |
histone deacetylase 7 |
increases expression |
ISO |
Nicotine results in increased expression of HDAC7 mRNA |
CTD |
PMID:24709674 |
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NCBI chr 7:128,923,918...128,961,926
Ensembl chr 7:128,923,920...128,962,072
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G |
Hddc2 |
HD domain containing 2 |
increases expression |
ISO |
Nicotine results in increased expression of HDDC2 mRNA |
CTD |
PMID:23825647 |
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NCBI chr 1:26,294,030...26,313,914
Ensembl chr 1:26,294,030...26,313,935
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G |
Hells |
helicase, lymphoid specific |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HELLS mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HELLS mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844
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G |
Hey1 |
hes-related family bHLH transcription factor with YRPW motif 1 |
increases expression |
ISO |
Nicotine results in increased expression of HEY1 mRNA |
CTD |
PMID:23825647 |
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NCBI chr 2:93,096,605...93,100,316
Ensembl chr 2:93,095,498...93,100,312
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G |
Hgf |
hepatocyte growth factor |
affects expression multiple interactions decreases expression |
EXP ISO |
Nicotine affects the expression of HGF mRNA [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of HGF mRNA Nicotine results in decreased expression of HGF protein |
CTD |
PMID:32512034 PMID:33091441 |
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NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
increases expression multiple interactions decreases expression |
ISO |
Nicotine results in increased expression of HIF1A protein CHRNA5 mutant form inhibits the reaction [Nicotine results in increased expression of HIF1A protein] resveratrol inhibits the reaction [Nicotine results in decreased expression of HIF1A mRNA] |
CTD |
PMID:22687363 PMID:24793809 |
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NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Hint1 |
histidine triad nucleotide binding protein 1 |
multiple interactions increases expression |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HINT1 mRNA; Mecamylamine inhibits the reaction [Nicotine results in increased expression of HINT1 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HINT1 mRNA] Nicotine results in increased expression of HINT1 mRNA |
CTD |
PMID:20230807 PMID:20514075 |
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NCBI chr10:38,989,516...38,993,259
Ensembl chr 4:92,100,973...92,101,568
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G |
Hipk1 |
homeodomain interacting protein kinase 1 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HIPK1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HIPK1 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 2:191,248,817...191,299,787
Ensembl chr 2:191,248,817...191,298,902
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G |
Hist1h2bc |
histone cluster 1, H2bc |
decreases expression |
ISO |
Nicotine results in decreased expression of H2BC4 mRNA |
CTD |
PMID:17456735 |
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NCBI chr17:42,692,335...42,696,601
Ensembl chr17:42,694,723...42,696,642
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G |
Hist1h2bd |
histone cluster 1 H2B family member D |
increases expression |
ISO |
Nicotine results in increased expression of H2BC5 protein |
CTD |
PMID:35929799 |
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NCBI chr17:42,792,887...42,793,268
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G |
Hltf |
helicase-like transcription factor |
decreases expression |
ISO |
Nicotine results in decreased expression of HLTF mRNA |
CTD |
PMID:18247414 |
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NCBI chr 2:102,549,724...102,609,492
Ensembl chr 2:102,549,724...102,609,327
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G |
Hmga1 |
high mobility group AT-hook 1 |
decreases expression |
ISO |
Nicotine results in decreased expression of HMGA1 mRNA |
CTD |
PMID:16949557 |
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NCBI chr20:5,611,088...5,618,755
Ensembl chr20:5,611,694...5,618,752
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
increases expression affects expression |
ISO EXP |
Nicotine results in increased expression of HMGCR mRNA Nicotine affects the expression of HMGCR mRNA |
CTD |
PMID:23416264 PMID:31972234 |
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NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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G |
Hmgcs1 |
3-hydroxy-3-methylglutaryl-CoA synthase 1 |
increases expression |
ISO |
Nicotine results in increased expression of HMGCS1 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
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G |
Hmox1 |
heme oxygenase 1 |
increases response to substance multiple interactions increases expression affects expression |
ISO EXP |
HMOX1 protein results in increased susceptibility to Nicotine [Lipopolysaccharides co-treated with Nicotine] results in increased expression of HMOX1 mRNA; [Lipopolysaccharides co-treated with Nicotine] results in increased expression of HMOX1 protein; [Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HMOX1 protein]; HMOX1 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA]; HMOX1 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; HMOX1 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 mRNA]]; HMOX1 protein promotes the reaction [Nicotine results in increased expression of ZFP36 mRNA]; HMOX1 protein promotes the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HMOX1 protein]; STAT3 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of HMOX1 mRNA] Nicotine results in increased expression of HMOX1 mRNA; Nicotine results in increased expression of HMOX1 protein Nicotine affects the expression of HMOX1 mRNA |
CTD |
PMID:22954530 PMID:23933227 PMID:23942037 PMID:24095726 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hnrnpa3 |
heterogeneous nuclear ribonucleoprotein A3 |
increases expression |
ISO |
Nicotine results in increased expression of HNRNPA3 mRNA |
CTD |
PMID:17456735 |
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NCBI chr 3:60,578,574...60,588,755
Ensembl chr 3:60,578,673...60,588,306
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G |
Hnrnpc |
heterogeneous nuclear ribonucleoprotein C |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HNRNPC mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HNRNPC mRNA] |
CTD |
PMID:20230807 |
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NCBI chr15:24,779,593...24,809,213
Ensembl chr15:24,779,450...24,809,183
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G |
Hnrnph2 |
heterogeneous nuclear ribonucleoprotein H2 |
increases expression |
ISO |
Nicotine results in increased expression of HNRNPH2 mRNA |
CTD |
PMID:17456735 |
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NCBI chr X:97,780,890...97,786,846
Ensembl chr X:97,780,785...97,787,041
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G |
Hnrnpl |
heterogeneous nuclear ribonucleoprotein L |
decreases expression |
ISO |
Nicotine results in decreased expression of HNRNPL mRNA |
CTD |
PMID:21955143 |
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NCBI chr 1:84,098,558...84,111,568
Ensembl chr 1:84,100,879...84,111,553
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G |
Hnrnpll |
heterogeneous nuclear ribonucleoprotein L-like |
increases expression |
ISO |
Nicotine results in increased expression of HNRNPLL mRNA |
CTD |
PMID:17997037 |
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NCBI chr 6:14,969,953...15,000,574
Ensembl chr 6:14,970,057...14,999,745
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G |
Hnrnpr |
heterogeneous nuclear ribonucleoprotein R |
increases expression |
ISO |
Nicotine results in increased expression of HNRNPR mRNA |
CTD |
PMID:17997037 |
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NCBI chr 5:148,542,999...148,574,888
Ensembl chr 5:148,543,044...148,574,867
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G |
Homer1 |
homer scaffold protein 1 |
decreases expression |
ISO |
Nicotine results in decreased expression of HOMER1 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
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G |
Hoxb9 |
homeo box B9 |
increases expression |
ISO |
Nicotine results in increased expression of HOXB9 mRNA |
CTD |
PMID:23825647 |
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NCBI chr10:81,237,312...81,240,818
Ensembl chr10:81,237,312...81,240,818
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G |
Hp1bp3 |
heterochromatin protein 1, binding protein 3 |
increases expression |
ISO |
Nicotine results in increased expression of HP1BP3 mRNA |
CTD |
PMID:16949557 |
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NCBI chr 5:150,435,781...150,463,004
Ensembl chr 5:150,433,740...150,463,000
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G |
Hpca |
hippocalcin |
increases expression |
ISO |
Nicotine results in increased expression of HPCA mRNA |
CTD |
PMID:21955143 |
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NCBI chr 5:141,455,616...141,466,252
Ensembl chr 5:141,455,613...141,463,841
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G |
Hpcal4 |
hippocalcin-like 4 |
increases expression |
ISO |
Nicotine results in increased expression of HPCAL4 mRNA |
CTD |
PMID:23825647 |
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NCBI chr 5:135,454,477...135,466,417
Ensembl chr 5:135,454,540...135,466,416
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G |
Hras |
HRas proto-oncogene, GTPase |
multiple interactions increases activity |
ISO EXP |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HRAS mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HRAS mRNA] Nicotine results in increased activity of HRAS protein |
CTD |
PMID:15983034 PMID:20230807 |
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NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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G |
Hsd11b1 |
hydroxysteroid 11-beta dehydrogenase 1 |
increases expression multiple interactions affects expression |
EXP ISO |
Nicotine results in increased expression of HSD11B1 mRNA ursodoxicoltaurine inhibits the reaction [Nicotine results in increased expression of HSD11B1 mRNA] Nicotine affects the expression of HSD11B1 mRNA |
CTD |
PMID:21955143 PMID:22265867 PMID:26803847 PMID:31972234 |
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NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
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G |
Hsd11b2 |
hydroxysteroid 11-beta dehydrogenase 2 |
decreases expression increases expression multiple interactions affects expression |
EXP ISO |
Nicotine results in decreased expression of HSD11B2 mRNA; Nicotine results in decreased expression of HSD11B2 protein Nicotine results in increased expression of HSD11B2 mRNA; Nicotine results in increased expression of HSD11B2 protein 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 protein]; EGR1 protein promotes the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; EGR1 protein promotes the reaction [Nicotine results in decreased expression of HSD11B2 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 protein] Nicotine affects the expression of HSD11B2 mRNA |
CTD |
PMID:22265867 PMID:29486207 PMID:31972234 |
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NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
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G |
Hsd17b1 |
hydroxysteroid (17-beta) dehydrogenase 1 |
multiple interactions decreases expression |
EXP ISO |
Taurine inhibits the reaction [Nicotine results in decreased expression of HSD17B1 protein] Nicotine results in decreased expression of HSD17B1 mRNA; Nicotine results in decreased expression of HSD17B1 protein |
CTD |
PMID:20498001 PMID:30959089 |
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NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927
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G |
Hsd17b3 |
hydroxysteroid (17-beta) dehydrogenase 3 |
decreases activity decreases expression |
EXP |
Nicotine results in decreased activity of HSD17B3 protein Nicotine results in decreased expression of HSD17B3 mRNA; Nicotine results in decreased expression of HSD17B3 protein |
CTD |
PMID:28986172 |
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NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554
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G |
Hsd17b7 |
hydroxysteroid (17-beta) dehydrogenase 7 |
increases splicing |
ISO |
Nicotine results in increased splicing of HSD17B7 mRNA alternative form |
CTD |
PMID:23825647 |
|
NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017
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G |
Hsd3b1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
decreases activity decreases expression |
EXP ISO |
Nicotine results in decreased activity of HSD3B1 protein Nicotine results in decreased expression of HSD3B1 mRNA; Nicotine results in decreased expression of HSD3B1 protein |
CTD |
PMID:28986172 PMID:30959089 |
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NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
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G |
Hsp90aa1 |
heat shock protein 90 alpha family class A member 1 |
multiple interactions increases expression |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HSP90AA1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSP90AA1 mRNA] Nicotine results in increased expression of HSP90AA1 mRNA; Nicotine results in increased expression of HSP90AA1 protein |
CTD |
PMID:12115584 PMID:20230807 |
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NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression multiple interactions |
ISO EXP |
Nicotine results in increased expression of HSPA5 Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HSPA5 protein]; Nicotine inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein] Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSPA5 protein] |
CTD |
PMID:18477628 PMID:24201001 PMID:28082123 |
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Hspe1 |
heat shock protein family E (Hsp10) member 1 |
multiple interactions |
ISO |
Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSPE1 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089
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G |
Htr1a |
5-hydroxytryptamine receptor 1A |
decreases expression increases expression decreases expression |
ISO EXP |
Nicotine results in decreased expression of HTR1A protein Nicotine results in increased expression of HTR1A protein Nicotine decreases expression of Htr1a protein in the diencephalon |
CTD RGD |
PMID:21324836 PMID:30247698 PMID:22921986 |
RGD:405850243 |
NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442
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G |
Htr1b |
5-hydroxytryptamine receptor 1B |
multiple interactions |
EXP |
Nicotine results in increased activity of [HTR1B protein binds to HTR2A protein] |
CTD |
PMID:21316381 |
|
NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549
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G |
Htr2a |
5-hydroxytryptamine receptor 2A |
multiple interactions increases expression |
EXP |
[Nicotine co-treated with Benzo(a)pyrene] results in decreased expression of HTR2A protein; Nicotine results in increased activity of [HTR1B protein binds to HTR2A protein] Nicotine results in increased expression of HTR2A protein |
CTD |
PMID:21316381 PMID:30247698 |
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NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
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G |
Ibsp |
integrin-binding sialoprotein |
decreases expression |
EXP |
Nicotine results in decreased expression of IBSP mRNA |
CTD |
PMID:29981921 |
|
NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693
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G |
Icam1 |
intercellular adhesion molecule 1 |
increases expression |
EXP |
Nicotine results in increased expression of ICAM1 protein |
CTD |
PMID:12575837 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Id1 |
inhibitor of DNA binding 1 |
decreases expression |
ISO |
Nicotine results in decreased expression of ID1 mRNA |
CTD |
PMID:17997037 |
|
NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
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G |
Id2 |
inhibitor of DNA binding 2 |
increases splicing |
ISO |
Nicotine results in increased splicing of ID2 mRNA alternative form |
CTD |
PMID:23825647 |
|
NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
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G |
Id3 |
inhibitor of DNA binding 3 |
decreases expression |
ISO |
Nicotine results in decreased expression of ID3 mRNA |
CTD |
PMID:17456735 |
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NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
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G |
Idi1 |
isopentenyl-diphosphate delta isomerase 1 |
decreases expression increases expression |
ISO |
Nicotine results in decreased expression of IDI1 mRNA Nicotine results in increased expression of IDI1 mRNA |
CTD |
PMID:16949557 PMID:17997037 |
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NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
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G |
Ifi27 |
interferon, alpha-inducible protein 27 |
increases expression multiple interactions |
ISO |
Nicotine results in increased expression of IFI27 mRNA Nicotine inhibits the reaction [nickel chloride results in increased expression of IFI27 mRNA] |
CTD |
PMID:23825647 PMID:37951547 |
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NCBI chr 6:122,590,461...122,596,996
Ensembl chr 6:122,590,472...122,779,294
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G |
Ifi44 |
interferon-induced protein 44 |
increases expression |
ISO |
Nicotine results in increased expression of IFI44 mRNA |
CTD |
PMID:23825647 |
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NCBI chr 2:240,626,058...240,643,879
Ensembl chr 2:240,626,066...240,643,844
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G |
Ifi44l |
interferon-induced protein 44-like |
increases expression |
ISO |
Nicotine results in increased expression of IFI44L mRNA |
CTD |
PMID:23825647 |
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NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:240,668,713...240,706,359
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G |
Ifih1 |
interferon induced with helicase C domain 1 |
multiple interactions |
ISO |
Nicotine inhibits the reaction [Poly I-C results in increased expression of IFIH1 mRNA] |
CTD |
PMID:31154625 |
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NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456
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G |
Ifitm1 |
interferon induced transmembrane protein 1 |
multiple interactions |
ISO |
[nickel chloride co-treated with Nicotine] results in increased expression of IFITM1 mRNA |
CTD |
PMID:37951547 |
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NCBI chr 1:196,067,163...196,069,169
Ensembl chr 1:196,067,963...196,069,169
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G |
Ifnar1 |
interferon alpha and beta receptor subunit 1 |
decreases expression |
ISO |
Nicotine results in decreased expression of IFNAR1 mRNA |
CTD |
PMID:18247414 |
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NCBI chr11:30,725,774...30,752,227
Ensembl chr11:30,725,790...30,749,979
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G |
Ifnb1 |
interferon beta 1 |
multiple interactions |
ISO |
IRF7 protein mutant form affects the reaction [Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]]; IRF7 protein mutant form inhibits the reaction [Nicotine inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]]; Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Nicotine inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein] |
CTD |
PMID:31154625 |
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NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
Nicotine inhibits the reaction [IFNG protein results in increased expression of TNF mRNA] |
CTD |
PMID:24095726 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Igf1 |
insulin-like growth factor 1 |
decreases expression multiple interactions increases expression affects expression |
EXP |
Nicotine results in decreased expression of IGF1 mRNA; Nicotine results in decreased expression of IGF1 protein rosiglitazone inhibits the reaction [Nicotine results in decreased expression of IGF1 protein] Nicotine results in increased expression of IGF1 mRNA Nicotine affects the expression of IGF1 mRNA; Nicotine affects the expression of IGF1 protein |
CTD |
PMID:20960268 PMID:22265867 PMID:29486207 PMID:31972234 |
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NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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G |
Igf1r |
insulin-like growth factor 1 receptor |
decreases expression increases expression affects expression |
EXP |
Nicotine results in decreased expression of IGF1R mRNA; Nicotine results in decreased expression of IGF1R protein Nicotine results in increased expression of IGF1R mRNA Nicotine affects the expression of IGF1R mRNA |
CTD |
PMID:20426880 PMID:20960268 PMID:22265867 PMID:31972234 |
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NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
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G |
Igf2 |
insulin-like growth factor 2 |
increases expression |
EXP |
Nicotine results in increased expression of IGF2 mRNA |
CTD |
PMID:29486207 |
|
NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
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G |
Igf2bp2 |
insulin-like growth factor 2 mRNA binding protein 2 |
increases expression |
ISO |
Nicotine results in increased expression of IGF2BP2 mRNA |
CTD |
PMID:17997037 |
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NCBI chr11:78,874,402...78,974,392
Ensembl chr11:78,874,414...78,974,377
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G |
Igfbp2 |
insulin-like growth factor binding protein 2 |
increases expression |
ISO |
Nicotine results in increased expression of IGFBP2 mRNA |
CTD |
PMID:23825647 |
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NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937
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G |
Igsf1 |
immunoglobulin superfamily, member 1 |
decreases expression |
ISO |
Nicotine results in decreased expression of IGSF1 mRNA |
CTD |
PMID:21955143 |
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NCBI chr X:129,069,891...129,085,331
Ensembl chr X:129,069,896...129,085,139
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G |
Igsf3 |
immunoglobulin superfamily, member 3 |
increases expression |
ISO |
Nicotine results in increased expression of IGSF3 mRNA |
CTD |
PMID:23825647 |
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NCBI chr 2:188,811,394...188,899,645
Ensembl chr 2:188,811,380...188,899,645
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G |
Ihh |
Indian hedgehog signaling molecule |
increases expression |
EXP |
Nicotine results in increased expression of IHH mRNA |
CTD |
PMID:27782041 |
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NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532
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G |
Il10 |
interleukin 10 |
decreases expression multiple interactions decreases secretion |
ISO |
Nicotine results in decreased expression of IL10 mRNA [Eugenol co-treated with Acetylcysteine] inhibits the reaction [Nicotine results in decreased secretion of IL10 protein]; Acetylcysteine inhibits the reaction [Nicotine results in decreased expression of IL10 mRNA]; Eugenol inhibits the reaction [Nicotine results in decreased expression of IL10 mRNA]; Nicotine inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein] Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein] |
CTD |
PMID:18247414 PMID:21237301 PMID:29673796 PMID:31926917 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il12a |
interleukin 12A |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]; Eugenol inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]; Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein] |
CTD |
PMID:21237301 |
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NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
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G |
Il12b |
interleukin 12B |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [Nicotine results in increased expression of IL12B mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]; Eugenol inhibits the reaction [Nicotine results in increased expression of IL12B mRNA]; Eugenol inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]; Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein] |
CTD |
PMID:21237301 |
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NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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G |
Il17a |
interleukin 17A |
multiple interactions |
ISO |
[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL17A mRNA; resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL17A mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL17A mRNA] |
CTD |
PMID:23199342 |
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NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il18 |
interleukin 18 |
multiple interactions increases secretion increases expression |
ISO EXP |
CHRNA5 protein affects the reaction [Nicotine results in increased secretion of IL18 protein] Nicotine results in increased expression of IL18 mRNA Nicotine results in increased expression of IL18 protein |
CTD |
PMID:35131329 PMID:39098741 |
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NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il1a |
interleukin 1 alpha |
multiple interactions |
ISO |
Nicotine results in increased expression of and results in increased secretion of IL1A protein |
CTD |
PMID:18082304 |
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NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression decreases expression increases secretion |
ISO EXP |
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 protein]]; [Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL1B mRNA; CHRNA5 protein affects the reaction [Nicotine results in increased secretion of IL1B protein]; Nicotine inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased secretion of IL1B protein]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 protein]; Nicotine promotes the reaction [IL1B protein results in increased secretion of CXCL8 protein]; Nicotine results in increased expression of and results in increased secretion of IL1B protein; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL1B mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL1B mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased secretion of IL1B protein]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 mRNA]]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased secretion of CXCL8 protein]]; U 0126 inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 protein]] Nicotine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] Nicotine results in increased expression of IL1B protein Nicotine results in increased expression of IL1B mRNA; Nicotine results in increased expression of IL1B protein [Nicotine results in increased abundance of Cotinine] which results in increased expression of IL1B mRNA; Nicotine inhibits the reaction [Acetic Acid results in increased expression of IL1B protein]; Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA] Nicotine results in decreased expression of IL1B protein |
CTD |
PMID:15976189 PMID:16254210 PMID:18082304 PMID:19673871 PMID:20943775 PMID:22119045 PMID:23199342 PMID:23810507 PMID:24095726 PMID:27180639 PMID:27766701 PMID:27984197 PMID:29617909 PMID:29642561 PMID:31926917 PMID:32473187 PMID:35131329 PMID:38229321 PMID:39098741 More...
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il1r1 |
interleukin 1 receptor type 1 |
multiple interactions increases expression |
EXP |
methyllycaconitine affects the reaction [Nicotine results in increased expression of IL1R1 mRNA]; methyllycaconitine affects the reaction [Nicotine results in increased expression of IL1R1 protein] Nicotine results in increased expression of IL1R1 mRNA; Nicotine results in increased expression of IL1R1 protein |
CTD |
PMID:27180639 |
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NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937
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G |
Il1rn |
interleukin 1 receptor antagonist |
multiple interactions |
EXP |
IL1RN protein inhibits the reaction [Nicotine results in increased activity of Capsaicin] |
CTD |
PMID:27180639 |
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NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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G |
Il2 |
interleukin 2 |
decreases response to substance |
ISO |
Nicotine results in decreased susceptibility to IL2 protein |
CTD |
PMID:15231866 |
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NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Il33 |
interleukin 33 |
increases secretion multiple interactions |
ISO |
Nicotine results in increased secretion of IL33 protein Nicotine promotes the reaction [Lipopolysaccharides results in increased secretion of IL33 protein] [Nicotine co-treated with Quartz] results in increased expression of IL33 protein |
CTD |
PMID:29673796 PMID:36868510 |
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NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
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G |
Il3ra |
interleukin 3 receptor subunit alpha |
decreases expression |
ISO |
Nicotine results in decreased expression of IL3RA mRNA |
CTD |
PMID:18247414 |
|
NCBI chr12:16,318,081...16,323,781
Ensembl chr12:16,318,081...16,323,484
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G |
Il4r |
interleukin 4 receptor |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of IL4RA mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL4RA mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980
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G |
Il6 |
interleukin 6 |
multiple interactions increases expression decreases expression decreases secretion increases secretion |
ISO EXP |
[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL6 mRNA; [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased secretion of IL6 protein; [Nicotine co-treated with Propylene Glycol co-treated with Glycerol] results in increased secretion of IL6 protein; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Nicotine results in increased expression of and results in increased secretion of IL6 protein; resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL6 mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL6 mRNA] Nicotine inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; ZFP36 mutant form inhibits the reaction [Nicotine results in decreased expression of IL6 mRNA] Nicotine results in increased expression of IL6 mRNA; Nicotine results in increased expression of IL6 protein Nicotine results in decreased expression of IL6 mRNA; Nicotine results in decreased expression of IL6 protein Nicotine results in decreased secretion of IL6 protein [Nicotine results in increased abundance of Cotinine] which results in increased expression of IL6 mRNA Nicotine results in increased secretion of IL6 protein |
CTD |
PMID:18082304 PMID:19673871 PMID:20943775 PMID:22093924 PMID:23199342 PMID:25396421 PMID:28065790 PMID:29617909 PMID:29673796 PMID:31926917 PMID:32473187 PMID:38229321 More...
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Il7 |
interleukin 7 |
multiple interactions |
ISO |
Nicotine results in increased expression of and results in increased secretion of IL7 protein |
CTD |
PMID:18082304 |
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NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075
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G |
Il9 |
interleukin 9 |
decreases expression |
ISO |
Nicotine results in decreased expression of IL9 mRNA |
CTD |
PMID:18247414 |
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NCBI chr17:8,111,772...8,114,895
Ensembl chr17:8,111,772...8,114,895
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G |
Inppl1 |
inositol polyphosphate phosphatase-like 1 |
decreases expression |
ISO |
Nicotine results in decreased expression of INPPL1 mRNA |
CTD |
PMID:17456735 |
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NCBI chr 1:156,183,043...156,197,500
Ensembl chr 1:156,183,059...156,197,500
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G |
Ins1 |
insulin 1 |
multiple interactions increases expression |
EXP ISO |
Sodium Acetate inhibits the reaction [Nicotine results in increased expression of INS1 protein] [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of CS mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of HGF mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of MMP2 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A protein; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PRDM16 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of UCP1 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of UCP1 protein; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of VEGFA mRNA |
CTD |
PMID:29155039 PMID:31857090 PMID:33091441 |
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NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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G |
Ins2 |
insulin 2 |
increases expression |
EXP |
Nicotine results in increased expression of INS2 mRNA |
CTD |
PMID:20426880 |
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NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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G |
Insig1 |
insulin induced gene 1 |
increases expression decreases expression |
ISO EXP |
Nicotine results in increased expression of INSIG1 mRNA Nicotine results in decreased expression of INSIG1 mRNA |
CTD |
PMID:23416264 PMID:26776438 |
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NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
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G |
Insr |
insulin receptor |
decreases expression |
EXP |
Nicotine results in decreased expression of INSR mRNA; Nicotine results in decreased expression of INSR protein |
CTD |
PMID:20960268 PMID:22265867 |
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NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
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G |
Irak1 |
interleukin-1 receptor-associated kinase 1 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRAK1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IRAK1 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr X:151,768,621...151,778,521
Ensembl chr X:151,768,777...151,778,521
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G |
Irf6 |
interferon regulatory factor 6 |
multiple interactions |
ISO |
[nickel chloride co-treated with Nicotine] results in increased expression of IRF6 mRNA |
CTD |
PMID:37951547 |
|
NCBI chr13:104,672,179...104,691,386
Ensembl chr13:104,672,179...104,691,386
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G |
Irf7 |
interferon regulatory factor 7 |
multiple interactions |
ISO |
IRF7 protein mutant form affects the reaction [Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]]; IRF7 protein mutant form inhibits the reaction [Nicotine inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]]; Nicotine inhibits the reaction [Poly I-C results in increased expression of IRF7 mRNA] |
CTD |
PMID:31154625 |
|
NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
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G |
Irf8 |
interferon regulatory factor 8 |
decreases expression multiple interactions |
ISO |
Nicotine results in decreased expression of IRF8 mRNA [nickel chloride co-treated with Nicotine] results in increased expression of IRF8 mRNA |
CTD |
PMID:17456735 PMID:37951547 |
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NCBI chr19:48,790,581...48,812,363
Ensembl chr19:48,790,588...48,811,829
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G |
Irf9 |
interferon regulatory factor 9 |
increases expression |
ISO |
Nicotine results in increased expression of IRF9 mRNA |
CTD |
PMID:33640489 |
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NCBI chr15:29,095,474...29,101,924
Ensembl chr15:29,095,789...29,101,236
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G |
Irs1 |
insulin receptor substrate 1 |
decreases expression |
EXP |
Nicotine results in decreased expression of IRS1 mRNA |
CTD |
PMID:22265867 |
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NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
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G |
Irx3 |
iroquois homeobox 3 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRX3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of IRX3 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr19:15,211,882...15,215,317
Ensembl chr19:15,211,878...15,215,317
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G |
Isg15 |
ISG15 ubiquitin-like modifier |
multiple interactions |
ISO |
Nicotine inhibits the reaction [Poly I-C results in increased expression of ISG15 mRNA] |
CTD |
PMID:31154625 |
|
NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
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G |
Isg20 |
interferon stimulated exonuclease gene 20 |
multiple interactions |
ISO |
[nickel chloride co-treated with Nicotine] results in increased expression of ISG20 mRNA |
CTD |
PMID:37951547 |
|
NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027
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G |
Itga2b |
integrin subunit alpha 2b |
decreases expression |
ISO |
Nicotine results in decreased expression of ITGA2B mRNA; Nicotine results in decreased expression of ITGA2B protein |
CTD |
PMID:21385097 |
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NCBI chr10:87,408,532...87,426,055
Ensembl chr10:87,408,536...87,426,168
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G |
Itgal |
integrin subunit alpha L |
decreases expression |
ISO |
Nicotine results in decreased expression of ITGAL mRNA |
CTD |
PMID:18247414 |
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NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732
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G |
Itgav |
integrin subunit alpha V |
increases expression |
ISO |
Nicotine results in increased expression of ITGAV mRNA |
CTD |
PMID:17997037 |
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NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639
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Itgb1 |
integrin subunit beta 1 |
decreases expression |
ISO |
Nicotine results in decreased expression of ITGB1 protein |
CTD |
PMID:11338295 |
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NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
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Itgb3 |
integrin subunit beta 3 |
decreases expression |
ISO |
Nicotine results in decreased expression of ITGB3 mRNA; Nicotine results in decreased expression of ITGB3 protein |
CTD |
PMID:21385097 |
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NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
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Itgb5 |
integrin subunit beta 5 |
increases expression |
EXP |
Nicotine results in increased expression of ITGB5 mRNA |
CTD |
PMID:20426880 |
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NCBI chr11:66,828,428...66,944,231
Ensembl chr11:66,829,285...66,944,472
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Itm2b |
integral membrane protein 2B |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ITM2B mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ITM2B mRNA] |
CTD |
PMID:20230807 |
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NCBI chr15:48,545,998...48,568,904
Ensembl chr15:48,546,001...48,568,917
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Itpkb |
inositol-trisphosphate 3-kinase B |
increases expression |
EXP |
Nicotine results in increased expression of ITPKB mRNA |
CTD |
PMID:11478936 |
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NCBI chr13:92,069,160...92,164,281
Ensembl chr13:92,069,216...92,162,004
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Ivl |
involucrin |
decreases expression |
ISO |
Nicotine results in decreased expression of IVL protein |
CTD |
PMID:16011614 |
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NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100
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Jagn1 |
jagunal homolog 1 |
decreases expression |
ISO |
Nicotine results in decreased expression of JAGN1 mRNA |
CTD |
PMID:17997037 |
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NCBI chr 4:146,591,577...146,596,287
Ensembl chr 4:146,591,510...146,596,288
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Jak2 |
Janus kinase 2 |
increases response to substance decreases expression multiple interactions increases phosphorylation |
ISO EXP |
JAK2 results in increased susceptibility to Nicotine Nicotine results in decreased expression of JAK2 mRNA Bungarotoxins inhibits the reaction [Nicotine results in increased phosphorylation of JAK2 protein] |
CTD |
PMID:20943775 PMID:29155039 PMID:34153408 |
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NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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Jmjd6 |
jumonji domain containing 6, arginine demethylase and lysine hydroxylase |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of JMJD6 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of JMJD6 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr10:102,041,131...102,047,182
Ensembl chr10:102,041,120...102,047,182
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Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases expression multiple interactions increases phosphorylation |
ISO EXP |
Nicotine results in increased expression of JUN protein [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of JUN protein]; Nicotine inhibits the reaction [Cisplatin results in increased expression of JUN mRNA] Nicotine results in increased phosphorylation of JUN protein Nicotine promotes the reaction [MAPK8 protein results in increased phosphorylation of JUN protein] |
CTD |
PMID:11592233 PMID:17003101 PMID:17021677 PMID:21511693 PMID:34890707 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Junb |
JunB proto-oncogene, AP-1 transcription factor subunit |
increases expression decreases expression |
ISO |
Nicotine results in increased expression of JUNB mRNA Nicotine results in decreased expression of JUNB mRNA |
CTD |
PMID:17456735 PMID:17997037 PMID:18805435 PMID:21955143 |
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NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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Kat6b |
lysine acetyltransferase 6B |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of KAT6B mRNA; Nicotine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of KAT6B mRNA] |
CTD |
PMID:20230807 |
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NCBI chr15:2,638,885...2,811,977
Ensembl chr15:2,639,200...2,812,316
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Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
increases expression |
ISO |
Nicotine results in increased expression of KCNH2 mRNA |
CTD |
PMID:17997037 |
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NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Kcnk1 |
potassium two pore domain channel subfamily K member 1 |
decreases expression |
EXP |
Nicotine results in decreased expression of KCNK1 mRNA |
CTD |
PMID:11478936 |
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NCBI chr19:53,959,411...53,997,726
Ensembl chr19:53,959,657...53,997,724
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Kdm7a |
lysine demethylase 7A |
increases expression |
ISO |
Nicotine results in increased expression of KDM7A mRNA |
CTD |
PMID:16949557 |
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NCBI chr 4:67,899,407...67,974,264
Ensembl chr 4:67,904,307...67,966,998
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Kdr |
kinase insert domain receptor |
increases expression decreases expression |
EXP |
Nicotine results in increased expression of KDR mRNA Nicotine results in decreased expression of KDR protein |
CTD |
PMID:32512034 PMID:33091441 |
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NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
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Kif21b |
kinesin family member 21B |
increases expression |
ISO |
Nicotine results in increased expression of KIF21B mRNA |
CTD |
PMID:23825647 |
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NCBI chr13:47,576,129...47,626,112
Ensembl chr13:47,576,160...47,626,127
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Kif3b |
kinesin family member 3B |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of KIF3B mRNA; Nicotine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of KIF3B mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 3:141,758,466...141,798,012
Ensembl chr 3:141,758,466...141,797,963
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Klf10 |
KLF transcription factor 10 |
decreases expression increases expression |
ISO |
Nicotine results in decreased expression of KLF10 mRNA Nicotine results in increased expression of KLF10 mRNA |
CTD |
PMID:17456735 PMID:17997037 |
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NCBI chr 7:69,467,658...69,473,726
Ensembl chr 7:69,465,619...69,473,994
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Klf11 |
KLF transcription factor 11 |
decreases expression |
ISO |
Nicotine results in decreased expression of KLF11 mRNA |
CTD |
PMID:18247414 |
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NCBI chr 6:41,285,699...41,297,548
Ensembl chr 6:41,285,842...41,297,550
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Klf4 |
KLF transcription factor 4 |
multiple interactions increases expression |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of KLF4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of KLF4 mRNA] Nicotine results in increased expression of KLF4 mRNA |
CTD |
PMID:17456735 PMID:20230807 |
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NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
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Klk5 |
kallikrein related-peptidase 5 |
increases expression |
ISO |
Nicotine results in increased expression of KLK5 mRNA |
CTD |
PMID:23825647 |
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NCBI chr 1:94,296,574...94,304,768
Ensembl chr 1:94,296,168...94,304,666
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Kmt2c |
lysine methyltransferase 2C |
multiple interactions decreases expression |
ISO |
alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA] |
CTD |
PMID:12588870 |
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NCBI chr 4:9,620,638...9,834,787
Ensembl chr 4:9,609,627...9,833,539
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Kng1 |
kininogen 1 |
multiple interactions decreases activity |
EXP |
Capsaicin promotes the reaction [Nicotine results in decreased activity of KNG1 protein alternative form]; Kainic Acid promotes the reaction [Nicotine results in decreased activity of KNG1 protein alternative form] |
CTD |
PMID:7807204 |
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NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555
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Krt15 |
keratin 15 |
increases expression |
ISO |
Nicotine results in increased expression of KRT15 mRNA |
CTD |
PMID:23825647 |
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NCBI chr10:85,066,797...85,070,614
Ensembl chr10:85,066,802...85,171,799
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Krt80 |
keratin 80 |
increases expression |
ISO |
Nicotine results in increased expression of KRT80 mRNA |
CTD |
PMID:23825647 |
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NCBI chr 7:132,463,216...132,485,134
Ensembl chr 7:132,463,218...132,485,508
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Krt85 |
keratin 85 |
increases expression |
ISO |
Nicotine results in increased expression of KRT85 mRNA |
CTD |
PMID:23825647 |
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NCBI chr 7:132,630,184...132,637,061
Ensembl chr 7:132,630,058...132,637,049
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Lamb1 |
laminin subunit beta 1 |
increases expression |
ISO |
Nicotine results in increased expression of LAMB1 mRNA |
CTD |
PMID:16949557 |
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NCBI chr 6:47,835,492...47,902,585
Ensembl chr 6:47,835,525...47,902,585
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Lamp2 |
lysosomal-associated membrane protein 2 |
decreases expression |
ISO |
Nicotine results in decreased expression of LAMP2 protein |
CTD |
PMID:33010382 |
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NCBI chr X:117,173,097...117,222,090
Ensembl chr X:117,057,606...117,260,522
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Lce1b |
late cornified envelope 1B |
increases expression |
ISO |
Nicotine results in increased expression of LCE1B mRNA |
CTD |
PMID:23825647 |
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NCBI chr 2:178,255,351...178,257,533
Ensembl chr 2:178,256,213...178,257,985
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Lck |
LCK proto-oncogene, Src family tyrosine kinase |
multiple interactions |
ISO |
LCK protein promotes the reaction [Nicotine results in increased phosphorylation of and results in increased activity of FYN protein]; Nicotine results in increased phosphorylation of and results in increased activity of LCK protein |
CTD |
PMID:17709503 |
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NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794
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Lcp1 |
lymphocyte cytosolic protein 1 |
affects response to substance |
ISO |
LCP1 gene SNP affects the susceptibility to Nicotine |
CTD |
PMID:18438686 |
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NCBI chr15:50,443,300...50,544,682
Ensembl chr15:50,488,149...50,544,680
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Ldlr |
low density lipoprotein receptor |
increases expression |
ISO |
Nicotine results in increased expression of LDLR mRNA |
CTD |
PMID:23416264 |
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NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
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Ldlrad3 |
low density lipoprotein receptor class A domain containing 3 |
increases splicing |
ISO |
Nicotine results in increased splicing of LDLRAD3 mRNA alternative form |
CTD |
PMID:23825647 |
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NCBI chr 3:88,239,529...88,481,340
Ensembl chr 3:88,239,622...88,481,267
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Lep |
leptin |
increases expression decreases response to substance |
EXP |
Nicotine results in increased expression of LEP protein Nicotine results in decreased susceptibility to LEP protein |
CTD |
PMID:23623838 PMID:29155039 |
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NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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Lepr |
leptin receptor |
increases expression decreases expression |
EXP |
Nicotine results in increased expression of LEPR mRNA Nicotine results in decreased expression of LEPR mRNA |
CTD |
PMID:22265867 PMID:29155039 |
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NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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Lgals1 |
galectin 1 |
increases expression |
ISO |
Nicotine results in increased expression of LGALS1 mRNA |
CTD |
PMID:23825647 |
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NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345
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Lhb |
luteinizing hormone subunit beta |
decreases expression increases secretion |
EXP ISO |
Nicotine results in decreased expression of LHB mRNA; Nicotine results in decreased expression of LHB protein Nicotine results in increased secretion of LHB protein |
CTD |
PMID:12893845 PMID:20498001 PMID:28986172 |
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NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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Lig4 |
DNA ligase 4 |
increases expression |
ISO |
Nicotine results in increased expression of LIG4 mRNA |
CTD |
PMID:16949557 |
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NCBI chr16:79,518,393...79,526,956
Ensembl chr16:79,518,312...79,527,040
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Lin7c |
lin-7 homolog C, crumbs cell polarity complex component |
decreases expression |
ISO |
Nicotine results in decreased expression of LIN7C mRNA |
CTD |
PMID:21955143 |
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NCBI chr 3:96,406,800...96,417,779
Ensembl chr 3:96,406,813...96,417,728
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Lipe |
lipase E, hormone sensitive type |
decreases expression |
EXP |
Nicotine results in decreased expression of LIPE mRNA |
CTD |
PMID:29155039 |
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NCBI chr 1:80,965,612...80,984,313
Ensembl chr 1:80,965,627...80,984,310
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Litaf |
lipopolysaccharide-induced TNF factor |
multiple interactions decreases expression increases expression |
ISO |
alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of LITAF mRNA]; Mecamylamine promotes the reaction [Nicotine results in decreased expression of LITAF mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of LITAF mRNA] Nicotine results in increased expression of LITAF mRNA |
CTD |
PMID:12588870 PMID:21955143 |
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NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763
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Lmo7 |
LIM domain 7 |
decreases expression |
ISO |
Nicotine results in decreased expression of LMO7 mRNA |
CTD |
PMID:21955143 |
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NCBI chr15:78,566,999...78,769,833
Ensembl chr15:78,567,023...78,769,783
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G |
Lpar4 |
lysophosphatidic acid receptor 4 |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of LPAR4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of LPAR4 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr X:72,033,486...72,046,978
Ensembl chr X:72,033,486...72,046,977
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Lpl |
lipoprotein lipase |
increases expression |
ISO |
Nicotine results in increased expression of LPL mRNA |
CTD |
PMID:21955143 |
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NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
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G |
Lrrfip1 |
LRR binding FLII interacting protein 1 |
increases expression |
ISO |
Nicotine results in increased expression of LRRFIP1 mRNA |
CTD |
PMID:16949557 |
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NCBI chr 9:91,592,032...91,720,250
Ensembl chr 9:91,643,197...91,720,250
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Lrrtm4 |
leucine rich repeat transmembrane neuronal 4 |
increases methylation |
EXP |
Nicotine results in increased methylation of LRRTM4 gene |
CTD |
PMID:32994467 |
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NCBI chr 4:112,545,874...113,338,713
Ensembl chr 4:112,545,917...113,335,865
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Ltb |
lymphotoxin beta |
decreases expression |
ISO |
Nicotine results in decreased expression of LTB mRNA |
CTD |
PMID:18247414 |
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NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381
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Ltf |
lactotransferrin |
decreases expression |
ISO |
Nicotine results in decreased expression of LTF mRNA |
CTD |
PMID:23825647 |
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NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795
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G |
Ltn1 |
listerin E3 ubiquitin protein ligase 1 |
multiple interactions |
ISO |
[Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of LTN1 mRNA |
CTD |
PMID:28065790 |
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NCBI chr11:26,603,903...26,660,871
Ensembl chr11:26,603,903...26,660,886
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G |
Lyl1 |
LYL1, basic helix-loop-helix family member |
decreases expression |
ISO |
Nicotine results in decreased expression of LYL1 mRNA |
CTD |
PMID:17456735 |
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NCBI chr19:23,452,140...23,455,007
Ensembl chr19:23,452,140...23,455,007
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G |
Lysmd3 |
LysM domain containing 3 |
affects response to substance |
ISO |
LYSMD3 gene SNP affects the susceptibility to Nicotine |
CTD |
PMID:18438686 |
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NCBI chr 2:11,933,787...11,939,944
Ensembl chr 2:11,933,768...11,942,961
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G |
Madd |
MAP-kinase activating death domain |
decreases expression |
ISO |
Nicotine results in decreased expression of MADD mRNA |
CTD |
PMID:18247414 |
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NCBI chr 3:77,114,330...77,157,865
Ensembl chr 3:77,114,314...77,157,701
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G |
Maoa |
monoamine oxidase A |
multiple interactions |
ISO |
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MAOA mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAOA mRNA] |
CTD |
PMID:20230807 |
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NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593
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