Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:superoxide
go back to main search page
Accession:CHEBI:18421 term browser browse the term
Definition:An oxygen radical that has formula O2.
Synonyms:exact_synonym: dioxidanidyl
 related_synonym: Dioxid(1-);   Formula=O2;   Hyperoxid;   InChI=1S/HO2/c1-2/h1H/p-1;   InChIKey=OUUQCZGPVNCOIJ-UHFFFAOYSA-M;   O2-;   SMILES=[O][O-];   Superoxide anion;   dioxide(1-);   hiperoxido;   hyperoxide;   superoxide radical;   superoxide radical anion;   superoxido;   superoxyde
 alt_id: CHEBI:15143;   CHEBI:26839;   CHEBI:7710
 xref: CAS:11062-77-4;   Chemspider:4514331;   FooDB:FDB022880;   Gmelin:487;   HMDB:HMDB0002168;   KEGG:C00704
 xref_mesh: MESH:D013481
 xref: MetaCyc:SUPER-OXIDE;   PDBeChem:2FK;   PMID:10440226;   PMID:10523323;   PMID:10588368;   PMID:11008114;   PMID:11333112;   PMID:11485972;   PMID:12097818;   PMID:12137408;   PMID:12598407;   PMID:14529453;   PMID:14703794;   PMID:14726604;   PMID:15586010;   PMID:15807660;   PMID:15952898;   PMID:1671684;   PMID:16771675;   PMID:16814528;   PMID:17052238;   PMID:17303648;   PMID:17531522;   PMID:18519744;   PMID:18827931;   PMID:19273321;   PMID:19482633;   PMID:19628033;   PMID:19857607;   PMID:19914407;   PMID:20868230;   PMID:21297912;   PMID:21434856;   PMID:21473702;   PMID:2160451;   PMID:217531;   PMID:22198225;   PMID:22247596;   PMID:22521482;   PMID:22729857;   PMID:22759590;   PMID:23542447;   PMID:23660153;   PMID:23668959;   PMID:24567847;   PMID:24862271;   PMID:2552230;   PMID:26047895;   PMID:26475962;   PMID:26875845;   PMID:27066025;   PMID:27066179;   PMID:27085844;   PMID:27357008;   PMID:27590268;   PMID:27965593;   PMID:28341974;   PMID:28599858;   PMID:28825637;   PMID:28842347;   PMID:28842493;   PMID:29259135;   PMID:29385710;   PMID:29669742;   PMID:29896077;   PMID:30307099;   PMID:30500433;   PMID:30573187;   PMID:30886134;   PMID:31254369;   PMID:31484901;   PMID:32144830;   PMID:32220789;   PMID:32478084;   PMID:32667121;   PMID:32760286;   PMID:32927603;   PMID:33248264;   PMID:33716500;   PMID:33805942;   PMID:34635271;   PMID:7998676;   PMID:8577306;   PMID:8720916;   PMID:8959373;   PMID:9337481;   Wikipedia:Superoxide


show annotations for term's descendants           Sort by:
superoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO ABCC1 protein affects the reaction [AGT protein results in increased abundance of Superoxides] CTD PMID:17272743 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Aco1 aconitase 1 decreases activity
multiple interactions		 ISO Superoxides results in decreased activity of ACO1 protein
[SOD1 protein results in decreased abundance of Superoxides] which results in increased expression of ACO1 protein		 CTD PMID:28542246 NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391 		JBrowse link
G Aco2 aconitase 2 multiple interactions
decreases activity		 EXP [[[Superoxides results in decreased activity of ACO2 protein] which results in increased abundance of Iron] which co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Hydroxyl Radical; [Superoxides results in decreased activity of ACO2 protein] which results in increased abundance of Iron CTD PMID:16162655 NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261 		JBrowse link
G Ada adenosine deaminase multiple interactions ISO ADA protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides] CTD PMID:10947063 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Agt angiotensinogen multiple interactions
increases abundance		 ISO
EXP		 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; ABCC1 protein affects the reaction [AGT protein results in increased abundance of Superoxides]; acetovanillone inhibits the reaction [AGT protein results in increased abundance of Superoxides]; ATOX1 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; NOS3 protein affects the reaction [AGT protein results in increased abundance of Superoxides]; Propranolol inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; SOD1 protein inhibits the reaction [AGT protein results in increased abundance of Superoxides]; SOD3 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; tempol inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; tempol inhibits the reaction [ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; acetovanillone inhibits the reaction [AGT protein results in increased abundance of Superoxides]; bisindolylmaleimide I inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; tempol inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]
AGT protein modified form results in increased abundance of Superoxides; AGT protein results in increased abundance of Superoxides
SOD1 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]		 CTD PMID:12606818 PMID:16531806 PMID:16864745 PMID:17272743 PMID:17391658 More... NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP [Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides] CTD PMID:23824088 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions ISO [AKR1C3 protein results in increased reduction of 9,10-phenanthrenequinone] which results in increased abundance of Superoxides; [AKR1C3 protein results in increased reduction of and affects the activity of benzo(a)pyrene-3,6-quinone] which results in increased chemical synthesis of Superoxides CTD PMID:19442656 PMID:21910479 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 multiple interactions ISO [[AKR7A2 protein co-treated with NADP] results in increased reduction of and affects the activity of 4-hydroxyequilenin-o-quinone] which results in increased chemical synthesis of Superoxides; [[AKR7A2 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione] which results in increased chemical synthesis of Superoxides CTD PMID:21910479 NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909 		JBrowse link
G Alb albumin increases chemical synthesis
multiple interactions		 ISO ALB protein modified form results in increased chemical synthesis of Superoxides
Etomidate promotes the reaction [ALB protein modified form results in increased chemical synthesis of Superoxides]		 CTD PMID:25421967 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Aldh5a1 aldehyde dehydrogenase 5 family, member A1 multiple interactions ISO [ALDH5A1 gene mutant form results in increased susceptibility to 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo(h)(1,6)naphthyridin-2(1H)-one] which results in increased abundance of Superoxides; [ALDH5A1 gene mutant form results in increased susceptibility to NCS 382] which results in increased abundance of Superoxides CTD PMID:29031482 NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677 		JBrowse link
G Apoe apolipoprotein E increases chemical synthesis
multiple interactions
increases abundance		 ISO APOE gene mutant form results in increased chemical synthesis of Superoxides
imisopasem manganese inhibits the reaction [APOE gene mutant form results in increased chemical synthesis of Superoxides]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [APOE gene mutant form results in increased abundance of Superoxides]		 CTD PMID:11397713 PMID:12871831 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G App amyloid beta precursor protein multiple interactions
increases chemical synthesis		 ISO 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine inhibits the reaction [APP gene mutant form results in increased chemical synthesis of Superoxides]; GW 501516 inhibits the reaction [APP gene mutant form results in increased chemical synthesis of Superoxides]; Resveratrol inhibits the reaction [APP protein results in increased abundance of Superoxides] CTD PMID:16212921 PMID:22886847 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Ar androgen receptor multiple interactions ISO Superoxides promotes the reaction [methylselenic acid results in decreased expression of AR protein] CTD PMID:16928829 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Arf6 ADP-ribosylation factor 6 multiple interactions ISO 1-Butanol inhibits the reaction [ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 1-Butanol inhibits the reaction [ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 2,3-Diphosphoglycerate inhibits the reaction [ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 2,3-Diphosphoglycerate inhibits the reaction [ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]; ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides] CTD PMID:10931844 NCBI chr 6:87,853,742...87,854,890
Ensembl chr 6:87,840,142...87,874,114 		JBrowse link
G Arrb2 arrestin, beta 2 affects abundance ISO ARRB2 protein affects the abundance of Superoxides CTD PMID:16210646 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Atox1 antioxidant 1 copper chaperone multiple interactions ISO ATOX1 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides] CTD PMID:22753205 NCBI chr10:39,564,855...39,579,892
Ensembl chr10:39,564,857...39,579,950 		JBrowse link
G Atp7a ATPase copper transporting alpha increases abundance
multiple interactions		 ISO ATP7A mutant form results in increased abundance of Superoxides
[ATP7A protein results in increased activity of SOD3 protein] which results in decreased chemical synthesis of Superoxides; ATP7A gene mutant form promotes the reaction [Streptozocin results in increased chemical synthesis of Superoxides]; ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]; ATP7A protein inhibits the reaction [Streptozocin results in increased chemical synthesis of Superoxides]; tempol inhibits the reaction [ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]]		 CTD PMID:18768397 PMID:23884884 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354 		JBrowse link
G C5 complement C5 multiple interactions
increases abundance		 ISO 8-(4-sulfophenyl)theophylline promotes the reaction [C5 protein modified form results in increased abundance of Superoxides]; Theophylline inhibits the reaction [C5 protein modified form results in increased abundance of Superoxides]; Theophylline promotes the reaction [C5 protein modified form results in increased abundance of Superoxides] CTD PMID:10947063 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994 		JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein]; CAT protein inhibits the reaction [Superoxides results in increased secretion of TGFB1 protein] CTD PMID:19268487 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cbs cystathionine beta synthase affects abundance
multiple interactions		 ISO CBS protein affects the abundance of Superoxides
SMPD1 protein affects the reaction [CBS protein affects the abundance of Superoxides]		 CTD PMID:23024785 NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression		 ISO Superoxides affects the reaction [Fructose results in increased secretion of CCL2 protein]
1,3-dimethylthiourea inhibits the reaction [Superoxides results in increased expression of CCL2 mRNA]		 CTD PMID:8856246 PMID:19158351 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cd38 CD38 molecule affects localization
multiple interactions		 ISO Superoxides affects the localization of CD38 protein
tempol inhibits the reaction [Superoxides affects the localization of CD38 protein]		 CTD PMID:23940720 NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986 		JBrowse link
G Crp C-reactive protein multiple interactions EXP CRP protein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides] CTD PMID:9767445 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
increases abundance		 ISO
EXP		 CYBA protein promotes the reaction [arsenite results in increased abundance of Superoxides]
CYBA protein results in increased abundance of Superoxides		 CTD PMID:10720412 PMID:14871555 PMID:20523355 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO CYBB mutant form inhibits the reaction [Homocysteine results in increased abundance of Superoxides]; CYBB protein affects the reaction [Folic Acid deficiency results in increased chemical synthesis of Superoxides]; CYBB protein affects the reaction [Homocysteine results in increased abundance of Superoxides]; CYBB protein promotes the reaction [[Doxorubicin co-treated with NADP] results in increased abundance of Superoxides]
IL1B protein promotes the reaction [CYBB protein results in increased chemical synthesis of Superoxides]		 CTD PMID:16354686 PMID:17275678 PMID:20116427 PMID:21647593 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases abundance ISO CYP1A1 protein results in increased abundance of Superoxides CTD PMID:20634294 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Dcxr dicarbonyl and L-xylulose reductase multiple interactions
increases chemical synthesis		 ISO [DCXR protein results in increased metabolism of Vitamin K 3] which results in increased chemical synthesis of Superoxides; Diacetyl inhibits the reaction [[DCXR protein results in increased metabolism of Vitamin K 3] which results in increased chemical synthesis of Superoxides]
DCXR protein results in increased chemical synthesis of Superoxides		 CTD PMID:28595002 NCBI chr10:106,006,404...106,008,293 JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases abundance
multiple interactions
increases expression		 ISO DDIT3 protein results in increased abundance of Superoxides
[DDIT3 protein results in increased abundance of Superoxides] which results in decreased expression of ITGA3 protein; [DDIT3 protein results in increased abundance of Superoxides] which results in decreased expression of ITGB1 protein
Superoxides results in increased expression of DDIT3 mRNA; Superoxides results in increased expression of DDIT3 protein		 CTD PMID:16400006 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Edn1 endothelin 1 multiple interactions
increases abundance		 EXP
ISO		 [EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides; Catechin inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]; NOS3 protein affects the reaction [[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides]; Polyphenols inhibits the reaction [[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides]
NOX1 mutant form inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]		 CTD PMID:20977430 PMID:23940720 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ednra endothelin receptor type A affects abundance EXP EDNRA protein affects the abundance of Superoxides CTD PMID:12600921 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Ep300 E1A binding protein p300 decreases abundance ISO EP300 protein results in decreased abundance of Superoxides CTD PMID:25440059 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Epo erythropoietin multiple interactions ISO EPO protein inhibits the reaction [[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides] CTD PMID:25490417 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor multiple interactions
increases abundance
decreases abundance		 ISO 3-aminobenzamide inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]; 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]; NU 1025 inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]
ERCC6 protein results in decreased abundance of Superoxides		 CTD PMID:25440059 NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol binds to and results in increased activity of ESR1 protein] which results in decreased abundance of Superoxides; [ESR1 protein results in increased susceptibility to Estradiol] which results in increased abundance of Superoxides; ESR1 protein affects the reaction [Estradiol results in decreased chemical synthesis of Superoxides] CTD PMID:18354059 PMID:23000059 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 multiple interactions
increases abundance		 ISO Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [FMR1 5' UTR mutant form results in increased abundance of Superoxides] CTD PMID:27385396 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050 		JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP Superoxides affects the reaction [Glucose results in increased expression of FN1 mRNA] CTD PMID:16572112 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 ISO SOD2 protein inhibits the reaction [Superoxides results in increased expression of FOS mRNA] CTD PMID:9067545 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO
EXP		 SOD2 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein]
UCP1 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein]		 CTD PMID:11050244 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Gas5 growth arrest specific 5 increases expression ISO Superoxides results in increased expression of GAS5 mRNA; Superoxides results in increased expression of GAS5 protein CTD PMID:16400006 NCBI chr13:73,303,611...73,306,932 JBrowse link
G Gch1 GTP cyclohydrolase 1 affects abundance ISO GCH1 protein affects the abundance of Superoxides CTD PMID:21963838 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases abundance
decreases abundance		 ISO
EXP		 [[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased abundance of Superoxides; Deferoxamine inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]; zinc protoporphyrin inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]
[[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased abundance of Superoxides; [cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in decreased abundance of Superoxides; [cobaltous chloride results in increased expression of HMOX1 protein] which results in decreased abundance of Superoxides; [stannous chloride results in increased activity of HMOX1 protein] which results in decreased abundance of Superoxides; [tin mesoporphyrin results in decreased activity of HMOX1 protein] which results in increased abundance of Superoxides; Deferoxamine inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]; zinc protoporphyrin inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]
[tetrathiomolybdate analog results in increased abundance of Superoxides] which results in increased reduction of HMOX1 protein
HMOX1 protein results in decreased abundance of Superoxides		 CTD PMID:15821039 PMID:16959961 PMID:18073186 PMID:18178725 PMID:18334666 More... NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hras HRas proto-oncogene, GTPase increases abundance
multiple interactions		 ISO HRAS protein mutant form results in increased abundance of Superoxides
[HRAS protein mutant form results in increased abundance of Superoxides] which results in decreased susceptibility to TNF protein		 CTD PMID:11313892 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions
decreases abundance		 ISO [tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in decreased abundance of Superoxides] which results in decreased expression of HSPB1 protein
HSPB1 protein results in decreased abundance of Superoxides		 CTD PMID:14975446 PMID:19193722 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Ier3 immediate early response 3 affects chemical synthesis ISO IER3 protein affects the chemical synthesis of Superoxides CTD PMID:20713914 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583 		JBrowse link
G Igf1 insulin-like growth factor 1 decreases abundance ISO IGF1 protein results in decreased abundance of Superoxides CTD PMID:22843358 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases abundance		 ISO diphenyleneiodonium inhibits the reaction [IL1B protein results in increased abundance of Superoxides]; IL1B protein promotes the reaction [CYBB protein results in increased chemical synthesis of Superoxides] CTD PMID:16354686 PMID:21211511 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO 1-Methyl-3-isobutylxanthine promotes the reaction [Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]]; Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]; ICI 118551 inhibits the reaction [Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]] CTD PMID:16238794 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP [TXN1 protein co-treated with INS1 protein] inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides] CTD PMID:20457604 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Itga3 integrin subunit alpha 3 multiple interactions ISO [DDIT3 protein results in increased abundance of Superoxides] which results in decreased expression of ITGA3 protein CTD PMID:16400006 NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118 		JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions ISO [DDIT3 protein results in increased abundance of Superoxides] which results in decreased expression of ITGB1 protein CTD PMID:16400006 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 EXP
ISO		 Superoxides affects the reaction [Glucose results in increased phosphorylation of JUN protein]
SOD2 protein inhibits the reaction [Superoxides results in increased expression of JUN mRNA]		 CTD PMID:9067545 PMID:16572112 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kat2a lysine acetyltransferase 2A decreases abundance ISO KAT2A protein results in decreased abundance of Superoxides CTD PMID:25440059 NCBI chr10:85,632,216...85,640,561
Ensembl chr10:85,632,216...85,640,166 		JBrowse link
G Kat2b lysine acetyltransferase 2B decreases abundance ISO KAT2B protein results in decreased abundance of Superoxides CTD PMID:25440059 NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064 		JBrowse link
G Kdr kinase insert domain receptor increases phosphorylation ISO Superoxides results in increased phosphorylation of KDR protein CTD PMID:19571580 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Lep leptin multiple interactions
increases abundance		 ISO acetovanillone inhibits the reaction [LEP protein results in increased abundance of Superoxides]; BQ 788 inhibits the reaction [LEP protein results in increased abundance of Superoxides]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [LEP protein results in increased abundance of Superoxides]
[LEP protein results in increased oxidation of Fatty Acids] which results in increased chemical synthesis of Superoxides		 CTD PMID:11342529 PMID:16380530 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lepr leptin receptor multiple interactions
increases abundance		 ISO acetovanillone inhibits the reaction [LEPR gene mutant form results in increased abundance of Superoxides]; resveratrol inhibits the reaction [LEPR gene mutant form results in increased abundance of Superoxides] CTD PMID:19478208 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 EXP
ISO		 Superoxides affects the reaction [Glucose results in increased phosphorylation of MAPK1 protein]
Superoxides results in increased phosphorylation of MAPK1 protein		 CTD PMID:16572112 PMID:19268487 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 EXP
ISO		 Superoxides affects the reaction [Glucose results in increased phosphorylation of MAPK3 protein]
Superoxides results in increased phosphorylation of MAPK3 protein		 CTD PMID:16572112 PMID:19268487 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO Superoxides results in increased phosphorylation of MAPK8 protein CTD PMID:33290831 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO Superoxides results in increased phosphorylation of MAPK9 protein CTD PMID:33290831 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [MPO protein results in increased oxidation of hydrazine] which results in increased chemical synthesis of Superoxides CTD PMID:26867495 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mt3 metallothionein 3 decreases response to substance ISO MT3 protein results in decreased susceptibility to Superoxides CTD PMID:12383939 NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP NCF1 protein affects the reaction [Lipopolysaccharides results in increased abundance of Superoxides] CTD PMID:17448908 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions EXP NCF2 protein affects the reaction [Lipopolysaccharides results in increased abundance of Superoxides] CTD PMID:17448908 NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO [Ozone results in increased expression of NOS2 protein] which results in increased abundance of Superoxides CTD PMID:11919077 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases abundance
decreases abundance
affects chemical synthesis		 ISO
EXP		 7,8-dihydrobiopterin promotes the reaction [NOS3 protein results in increased abundance of Superoxides]; [Equol results in increased chemical synthesis of Superoxides] which results in increased activity of and results in increased phosphorylation of NOS3 protein; sapropterin deficiency inhibits the reaction [NOS3 protein results in increased abundance of Superoxides]; sapropterin deficiency promotes the reaction [NOS3 protein results in increased abundance of Superoxides]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Equol results in increased chemical synthesis of Superoxides] which results in increased phosphorylation of NOS3 protein]
[Calcimycin results in increased activity of NOS3 protein] which results in increased abundance of Superoxides; Nitroglycerin promotes the reaction [[Calcimycin results in increased activity of NOS3 protein] which results in increased abundance of Superoxides]; NOS3 protein affects the reaction [[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides]
[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides; EPO protein inhibits the reaction [[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides]; NOS3 protein affects the reaction [AGT protein results in increased abundance of Superoxides]
NOS3 protein results in decreased abundance of Superoxides
NOS3 protein affects the chemical synthesis of Superoxides		 CTD PMID:10625313 PMID:17272743 PMID:18714161 PMID:19011239 PMID:19696404 More... NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions
increases abundance		 EXP
ISO		 [Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides]; NOX1 mRNA promotes the reaction [Tobacco Smoke Pollution results in increased chemical synthesis of Superoxides]
diphenyleneiodonium inhibits the reaction [NOX1 protein results in increased abundance of Superoxides]; NOX1 mutant form inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]		 CTD PMID:23824088 PMID:23940720 PMID:24912985 PMID:27816504 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Nox3 NADPH oxidase 3 multiple interactions ISO [resveratrol results in decreased expression of and results in decreased activity of NOX3 protein] which results in decreased abundance of Superoxides CTD PMID:20675566 NCBI chr 1:44,238,012...44,302,851
Ensembl chr 1:44,236,992...44,302,851 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO NOX4 promotes the reaction [sodium arsenite results in increased abundance of Superoxides] CTD PMID:26535918 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions ISO PARK7 protein affects the reaction [Paraquat results in increased abundance of Superoxides] CTD PMID:21300143 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 affects abundance ISO PDHA1 protein affects the abundance of Superoxides CTD PMID:21846590 NCBI chr  X:34,700,481...34,714,309
Ensembl chr  X:34,700,409...34,714,311 		JBrowse link
G Pink1 PTEN induced kinase 1 affects abundance ISO PINK1 protein affects the abundance of Superoxides CTD PMID:21421046 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Polg DNA polymerase gamma, catalytic subunit increases chemical synthesis
multiple interactions		 ISO POLG gene mutant form results in increased chemical synthesis of Superoxides
Mn(III) meso-tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin inhibits the reaction [POLG protein results in increased chemical synthesis of Superoxides]; polyethylene glycol-superoxide dismutase inhibits the reaction [POLG gene mutant form results in increased chemical synthesis of Superoxides]; Rotenone promotes the reaction [POLG gene mutant form results in increased chemical synthesis of Superoxides]		 CTD PMID:30038268 NCBI chr 1:133,382,764...133,399,578
Ensembl chr 1:133,382,766...133,398,567 		JBrowse link
G Pomc proopiomelanocortin increases abundance EXP POMC protein results in increased abundance of Superoxides CTD PMID:16620303 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Pon2 paraoxonase 2 increases expression ISO Superoxides results in increased expression of PON2 protein CTD PMID:15544923 NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides; [POR protein results in increased metabolism of Paraquat] which results in increased abundance of Superoxides; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased abundance of Superoxides]
[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides]		 CTD PMID:21215309 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO [Ethanol results in increased localization of and results in increased activity of PRKCA protein] promotes the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides] CTD PMID:10651808 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkcb protein kinase C, beta multiple interactions ISO [Ethanol results in increased localization of and results in increased activity of PRKCB protein] promotes the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides] CTD PMID:10651808 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 ISO resveratrol inhibits the reaction [Superoxides results in increased expression of PTGS2 protein] CTD PMID:10718345 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO [resveratrol results in decreased activity of RPS6KB1 protein] which results in decreased abundance of Superoxides; [Sirolimus results in decreased activity of RPS6KB1 protein] which results in decreased abundance of Superoxides CTD PMID:21544240 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Selenoh selenoprotein H decreases abundance ISO SELENOH protein results in decreased abundance of Superoxides CTD PMID:17389926 NCBI chr 3:69,751,850...69,753,417
Ensembl chr 3:69,752,757...69,753,417 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [[Superoxides co-treated with Hydroxyl Radical] results in increased oxidation of LPA protein] which results in decreased secretion of SERPINE1 protein CTD PMID:11681624 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Superoxides]] CTD PMID:18424637 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc25a14 solute carrier family 25 member 14 multiple interactions ISO SLC25A14 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased abundance of Superoxides]; SLC25A14 protein inhibits the reaction [Dopamine results in increased abundance of Superoxides] CTD PMID:20600837 NCBI chr  X:127,807,630...127,845,823
Ensembl chr  X:127,807,449...127,845,823 		JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 multiple interactions ISO SMPD1 protein affects the reaction [CBS protein affects the abundance of Superoxides] CTD PMID:23024785 NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794 		JBrowse link
G Sod1 superoxide dismutase 1 increases abundance
multiple interactions
decreases chemical synthesis
decreases abundance		 ISO SOD1 protein results in increased abundance of Superoxides
[SOD1 protein results in decreased abundance of Superoxides] which results in increased expression of ACO1 protein; SOD1 protein inhibits the reaction [AGT protein results in increased abundance of Superoxides]
SOD1 protein results in decreased chemical synthesis of Superoxides
[[Chelating Agents binds to Copper] which affects the activity of SOD1 protein] which results in increased abundance of Superoxides; [tetrathiomolybdate results in decreased activity of SOD1 protein] which results in increased abundance of Superoxides; SOD1 protein inhibits the reaction [[spermine nitric oxide complex results in increased abundance of Nitric Oxide] which results in increased abundance of Superoxides]; SOD1 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]		 CTD PMID:11756504 PMID:12489993 PMID:15364863 PMID:15829915 PMID:17391658 More... NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 increases metabolic processing
affects abundance
affects chemical synthesis
multiple interactions
decreases abundance
increases expression
affects metabolic processing		 ISO
EXP		 SOD2 protein results in increased metabolism of Superoxides
SOD2 protein affects the abundance of Superoxides
SOD2 protein affects the chemical synthesis of Superoxides
[SOD2 protein results in increased metabolism of Superoxides] which results in increased chemical synthesis of Hydrogen Peroxide; Tamoxifen inhibits the reaction [SOD2 protein affects the abundance of Superoxides]
SOD2 protein results in decreased abundance of Superoxides
[Rotenone results in increased abundance of Superoxides] which results in increased expression of SOD2 protein; [TNF protein results in increased expression of SOD2 protein] which results in decreased susceptibility to Superoxides; SOD2 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein]
Superoxides results in increased expression of SOD2 protein
[tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in decreased abundance of Superoxides] which results in decreased expression of SOD2 protein; SOD2 protein affects the reaction [Troglitazone results in increased abundance of Superoxides]; SOD2 protein inhibits the reaction [sodium arsenite results in increased abundance of Superoxides]; SOD2 protein inhibits the reaction [Superoxides results in increased expression of FOS mRNA]; SOD2 protein inhibits the reaction [Superoxides results in increased expression of JUN mRNA]
SOD2 protein polymorphism affects the metabolism of Superoxides		 CTD PMID:1850207 PMID:9067545 PMID:11050244 PMID:16179351 PMID:17150972 More... NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions ISO [ATP7A protein results in increased activity of SOD3 protein] which results in decreased chemical synthesis of Superoxides; [Streptozocin results in decreased activity of SOD3 protein] which results in increased chemical synthesis of Superoxides; SOD3 gene mutant form promotes the reaction [Streptozocin results in increased chemical synthesis of Superoxides]; SOD3 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides] CTD PMID:16864745 PMID:23884884 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases abundance
increases secretion		 EXP
ISO		 Superoxides affects the reaction [Glucose results in increased expression of TGFB1 mRNA]
TGFB1 protein results in increased abundance of Superoxides
[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein; CAT protein inhibits the reaction [[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein]; CAT protein inhibits the reaction [Superoxides results in increased secretion of TGFB1 protein]		 CTD PMID:12606818 PMID:16572112 PMID:19268487 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases abundance
decreases abundance
affects abundance		 ISO [HRAS protein mutant form results in increased abundance of Superoxides] which results in decreased susceptibility to TNF protein; [N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides; [TNF protein results in increased expression of SOD2 protein] which results in decreased susceptibility to Superoxides; acetovanillone inhibits the reaction [TNF protein results in increased abundance of Superoxides]; Acetylcysteine inhibits the reaction [TNF protein results in increased abundance of Superoxides]; cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased abundance of Superoxides]; Cyclosporine inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased abundance of Superoxides]; Tacrolimus inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides]
TNF protein inhibits the reaction [Dichloroacetic Acid results in increased abundance of Superoxides]
TNF gene mutant form results in decreased abundance of Superoxides
TNF protein affects the abundance of Superoxides		 CTD PMID:1850207 PMID:11121130 PMID:11313892 PMID:15450858 PMID:19478208 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Txn1 thioredoxin 1 multiple interactions EXP [TXN1 protein co-treated with INS1 protein] inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides] CTD PMID:20457604 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions EXP [TXN1 protein co-treated with INS1 protein] inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; [TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides; Auranofin inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Dinitrochlorobenzene promotes the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Dithionitrobenzoic Acid inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; formic acid promotes the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Oxygen deficiency inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Pentetic Acid promotes the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Sodium Selenite inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides] CTD PMID:20457604 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions EXP UCP1 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein] CTD PMID:11050244 NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852 		JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions
decreases abundance		 EXP
ISO		 [[benzo(a)pyrene-1,6-quinone results in increased abundance of Superoxides] co-treated with [benzo(a)pyrene-1,6-quinone results in decreased abundance of Hydrogen Peroxide]] results in increased expression of UCP2 mRNA
UCP2 protein results in decreased abundance of Superoxides		 CTD PMID:10860543 PMID:25440059 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
G Vav2 vav guanine nucleotide exchange factor 2 multiple interactions
increases abundance		 ISO 2-acetylphenothiazine inhibits the reaction [VAV2 protein results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [VAV2 protein results in increased abundance of Superoxides] CTD PMID:23940720 NCBI chr 3:10,584,688...10,754,128
Ensembl chr 3:10,584,688...10,754,052 		JBrowse link
G Vdr vitamin D receptor decreases abundance ISO VDR protein results in decreased abundance of Superoxides CTD PMID:25201890 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions
increases chemical synthesis		 ISO [[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein; CAT protein inhibits the reaction [[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein]; taxifolin inhibits the reaction [XDH protein results in increased chemical synthesis of Superoxides] CTD PMID:19268487 PMID:19555678 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    chemical entity 19920
      molecular entity 19920
        elemental molecular entity 17203
          elemental oxygen 9103
            diatomic oxygen 4029
              superoxide 97
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      chalcogen 19587
                        oxygen atom 19587
                          oxygen molecular entity 19587
                            elemental oxygen 9103
                              diatomic oxygen 4029
                                superoxide 97
paths to the root