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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:histamine
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Accession:CHEBI:18295 term browser browse the term
Definition:A member of the class of imidazoles that is 1H-imidazole substituted at position C-4 by a 2-aminoethyl group.
Synonyms:related_synonym: 1H-Imidazole-4-ethanamine;   2-(1H-Imidazol-4-yl)ethanamine;   2-(4-Imidazolyl)ethylamine;   Formula=C5H9N3;   InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8);   InChIKey=NTYJJOPFIAHURM-UHFFFAOYSA-N;   SMILES=NCCc1c[nH]cn1
 alt_id: CHEBI:14401;   CHEBI:24596;   CHEBI:43187;   CHEBI:817
 xref: CAS:51-45-6;   Drug_Central:1375;   Gmelin:2968;   HMDB:HMDB0000870;   KEGG:C00388;   KEGG:D08040;   KNApSAcK:C00001414
 xref_mesh: MESH:D006632
 xref: MetaCyc:HISTAMINE;   PDBeChem:HSM;   PMID:16399866;   PMID:19547708;   PMID:19843401;   PMID:22770225;   PMID:24101735;   Reaxys:2012;   Wikipedia:Histamine
 cyclic_relationship: is_conjugate_base_of CHEBI:58432


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histamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]; [BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine; Imatinib Mesylate inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]; nilotinib inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine] CTD PMID:16849647 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Adcyap1 adenylate cyclase activating polypeptide 1 increases secretion
multiple interactions		 EXP ADCYAP1 protein results in increased secretion of Histamine
Dinoprostone inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]; Galanin inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]; IL1B protein inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]; Misoprostol inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]; SST protein inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]; TNF protein inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]		 CTD PMID:11164953 NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773 		JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions
increases activity
decreases response to substance		 ISO
EXP		 Histamine promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]
Histamine results in increased activity of ADRB2 protein
[Epinephrine results in increased activity of ADRB2 protein] which results in increased secretion of Histamine; [Isoproterenol results in increased activity of ADRB2 protein] which results in increased secretion of Histamine; [Terbutaline results in increased activity of ADRB2 protein] which results in increased secretion of Histamine
ADRB2 results in decreased susceptibility to Histamine
Alprenolol inhibits the reaction [ADRB2 results in decreased susceptibility to Histamine]; Carvedilol inhibits the reaction [ADRB2 results in decreased susceptibility to Histamine]; ICI 118551 inhibits the reaction [ADRB2 results in decreased susceptibility to Histamine]		 CTD PMID:11164953 PMID:12198331 PMID:17196553 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO ALOX5 protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]; zileuton inhibits the reaction [ALOX5 protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]] CTD PMID:9609743 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein multiple interactions ISO ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]; L 655238 inhibits the reaction [ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]]; MK-886 inhibits the reaction [ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]] CTD PMID:9609743 NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986 		JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor decreases secretion EXP AMBP protein results in decreased secretion of Histamine CTD PMID:9579392 NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331 		JBrowse link
G Aoc1 amine oxidase, copper containing 1 increases metabolic processing ISO AOC1 protein results in increased metabolism of Histamine CTD PMID:12072962 NCBI chr 4:77,812,260...77,831,846
Ensembl chr 4:77,812,260...77,831,840 		JBrowse link
G Aqp5 aquaporin 5 affects localization
multiple interactions
decreases expression		 ISO Histamine affects the localization of AQP5 protein
Glycyrrhizic Acid inhibits the reaction [Histamine results in decreased expression of AQP5 protein]; prolinedithiocarbamate inhibits the reaction [Histamine results in decreased expression of AQP5 protein]		 CTD PMID:19443731 PMID:29452068 NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Histamine results in increased expression of BAX mRNA CTD PMID:36565801 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP Histamine results in decreased expression of BCL2 mRNA CTD PMID:36565801 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcr BCR activator of RhoGEF and GTPase multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]; [BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine; Imatinib Mesylate inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]; nilotinib inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine] CTD PMID:16849647 NCBI chr20:13,469,325...13,596,942
Ensembl chr20:13,471,668...13,597,016 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions
increases secretion		 EXP [KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein; Dinoprostone inhibits the reaction [Flurbiprofen inhibits the reaction [Histamine results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]]; Flurbiprofen inhibits the reaction [Histamine results in increased secretion of CALCA protein]; Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein] CTD PMID:11166334 PMID:12791437 PMID:14991081 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Casp3 caspase 3 increases expression EXP Histamine results in increased expression of CASP3 mRNA; Histamine results in increased expression of CASP3 protein CTD PMID:36565801 PMID:38348711 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase affects expression
decreases activity		 ISO
EXP		 Histamine affects the expression of CAT protein
Histamine results in decreased activity of CAT protein		 CTD PMID:17729160 PMID:36565801 PMID:38348711 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Lipopolysaccharides promotes the reaction [Histamine results in increased expression of CCL2 protein]; TNF protein promotes the reaction [Histamine results in increased expression of CCL2 protein] CTD PMID:11336536 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [HRH4 protein results in increased susceptibility to Histamine] which results in decreased expression of CCND1 protein CTD PMID:22363581 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cd14 CD14 molecule affects expression
multiple interactions		 ISO Histamine affects the expression of CD14 protein
HRH2 protein affects the reaction [Histamine affects the expression of CD14 protein]		 CTD PMID:14499251 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cd40 CD40 molecule multiple interactions ISO [alpha-fluoromethylhistamine results in decreased chemical synthesis of Histamine] which results in decreased expression of CD40 protein; [tiotidine inhibits the reaction [Histamine binds to and results in increased activity of HRH2 protein]] which results in decreased expression of CD40 protein; [Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of CD40 protein CTD PMID:11306145 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cd80 Cd80 molecule multiple interactions ISO Famotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]]; Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]] CTD PMID:12538815 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO [HRH4 protein results in increased susceptibility to Histamine] which results in decreased expression of CDK2 protein CTD PMID:22363581 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [HRH4 protein results in increased susceptibility to Histamine] which results in increased expression of CDKN1A protein CTD PMID:22363581 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO [HRH4 protein results in increased susceptibility to Histamine] which results in increased expression of CDKN1B protein CTD PMID:22363581 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions
affects response to substance		 ISO CHRM3 protein affects the reaction [Histamine results in increased secretion of Acids]
CHRM3 protein affects the susceptibility to Histamine		 CTD PMID:14724830 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
G Clca1 chloride channel accessory 1 increases expression ISO Histamine results in increased expression of CLCA1 mRNA CTD PMID:17622767 NCBI chr 2:233,938,677...233,964,369
Ensembl chr 2:233,938,677...233,964,369 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
decreases phosphorylation		 ISO Glycyrrhizic Acid inhibits the reaction [Histamine results in decreased phosphorylation of CREB1 protein]; prolinedithiocarbamate inhibits the reaction [Histamine results in decreased phosphorylation of CREB1 protein] CTD PMID:29452068 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Csf1 colony stimulating factor 1 decreases expression ISO Histamine results in decreased expression of CSF1 mRNA CTD PMID:9657254 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704 		JBrowse link
G Csf2 colony stimulating factor 2 increases expression
increases secretion
multiple interactions		 ISO
EXP		 Histamine results in increased expression of CSF2 protein
CSF2 results in increased secretion of Histamine
Histamine results in increased secretion of CSF2 protein
Particulate Matter analog promotes the reaction [Histamine results in increased secretion of CSF2 protein]; Vehicle Emissions analog promotes the reaction [Histamine results in increased secretion of CSF2 protein]		 CTD PMID:9606035 PMID:9685678 PMID:9856766 PMID:10051702 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Edn1 endothelin 1 multiple interactions ISO EDN1 protein results in decreased activity of [Atropine co-treated with Histamine] CTD PMID:12906840 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO EGFR protein affects the reaction [Histamine results in increased secretion of MMP1 protein] CTD PMID:17656145 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions
increases expression
increases activity		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Histamine results in increased expression of F3]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Histamine results in increased expression of F3]; [Histamine co-treated with splitomicin] results in increased expression of F3 protein; Chlorpheniramine inhibits the reaction [Histamine results in increased expression of F3]; Diphenhydramine inhibits the reaction [Histamine results in increased expression of F3]; pyrazolanthrone inhibits the reaction [Histamine results in increased expression of F3]; Pyrilamine inhibits the reaction [Histamine results in increased activity of F3 protein]; Pyrilamine inhibits the reaction [Histamine results in increased expression of F3]; SB 203580 inhibits the reaction [Histamine results in increased expression of F3]; wortmannin promotes the reaction [Histamine results in increased expression of F3]
Histamine results in increased expression of F3 mRNA; Histamine results in increased expression of F3 protein		 CTD PMID:16009787 PMID:20978007 PMID:25569083 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fcer1a Fc epsilon receptor Ia affects secretion ISO FCER1A polymorphism affects the secretion of Histamine CTD PMID:17125826 NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351 		JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression EXP Histamine results in increased expression of FGF1 protein CTD PMID:15264218 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Histamine binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA; Famotidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA] CTD PMID:9187264 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gast gastrin affects abundance
increases secretion
affects activity
multiple interactions		 ISO
EXP		 GAST protein affects the abundance of Histamine
GAST protein modified form results in increased secretion of Histamine; GAST protein results in increased secretion of Histamine
Histamine affects the activity of GAST protein
[fluanisone co-treated with Fentanyl co-treated with Midazolam] inhibits the reaction [GAST protein results in increased secretion of Histamine]; alpha-methylhistamine inhibits the reaction [GAST protein modified form results in increased secretion of Histamine]; Chloral Hydrate inhibits the reaction [GAST protein results in increased secretion of Histamine]; CXCL8 protein inhibits the reaction [GAST protein results in increased secretion of Histamine]; Dinoprostone inhibits the reaction [GAST protein results in increased secretion of Histamine]; Galanin inhibits the reaction [GAST protein results in increased secretion of Histamine]; Impromidine inhibits the reaction [GAST protein modified form results in increased secretion of Histamine]; Misoprostol inhibits the reaction [GAST protein results in increased secretion of Histamine]; Pentobarbital inhibits the reaction [GAST protein results in increased secretion of Histamine]; SST protein inhibits the reaction [GAST protein results in increased secretion of Histamine]; TNF protein inhibits the reaction [GAST protein results in increased secretion of Histamine]; Urethane inhibits the reaction [GAST protein results in increased secretion of Histamine]		 CTD PMID:2470453 PMID:10864877 PMID:11164953 PMID:12190085 PMID:12893847 More... NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496 		JBrowse link
G Ghrl ghrelin and obestatin prepropeptide multiple interactions EXP Histamine affects the reaction [GHRL protein results in increased secretion of Acids] CTD PMID:16838121 NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621 		JBrowse link
G Gusb glucuronidase, beta multiple interactions
increases expression		 ISO fexofenadine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of GUSB protein]; fexofenadine inhibits the reaction [Histamine results in increased expression of GUSB protein]; HRH1 protein promotes the reaction [Histamine results in increased expression of GUSB protein] CTD PMID:11238657 NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905 		JBrowse link
G Hdc histidine decarboxylase increases chemical synthesis
multiple interactions		 EXP
ISO		 HDC protein results in increased chemical synthesis of Histamine
[troglitazone results in decreased expression of HDC mRNA] which results in decreased secretion of Histamine		 CTD PMID:11834241 PMID:17075268 NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341 		JBrowse link
G Hnmt histamine N-methyltransferase increases methylation
multiple interactions		 ISO HNMT protein results in increased methylation of Histamine
SK&F 91488 inhibits the reaction [HNMT protein results in increased methylation of Histamine]		 CTD PMID:7943261 NCBI chr 3:6,591,804...6,623,821
Ensembl chr 3:6,591,463...6,624,012 		JBrowse link
G Hrh1 histamine receptor H 1 increases activity
affects binding
multiple interactions
increases expression
affects response to substance		 ISO
EXP		 Histamine results in increased activity of HRH1 protein
HRH1 protein binds to Histamine
1-Methyl-3-isobutylxanthine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP]]; [Histamine results in increased activity of HRH1 protein] which results in increased abundance of Calcium; [HRH1 protein binds to Histamine] which results in increased import of Calcium; [Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of CD40 protein; [Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of PTPRC protein; Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]]; fexofenadine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased abundance of Calcium]; fexofenadine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of GUSB protein]; Guanosine Triphosphate analog affects the reaction [Histamine inhibits the reaction [Pyrilamine binds to HRH1 protein]]; Histamine inhibits the reaction [Pyrilamine binds to HRH1 protein]; Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]; HRH1 affects the reaction [Histamine promotes the reaction [TLR2 results in increased expression of PTGS2]]; HRH1 protein affects the reaction [Histamine results in increased transport of fluorescein isothiocyanate bovine serum albumin]; HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP]; HRH1 protein promotes the reaction [Histamine results in increased export of Calcium]; HRH1 protein promotes the reaction [Histamine results in increased expression of GUSB protein]; HRH1 protein promotes the reaction [Histamine results in increased expression of IL6 protein]; HRH1 protein promotes the reaction [Histamine results in increased metabolism of Phosphatidylinositols]; Quercetin inhibits the reaction [Histamine results in increased expression of HRH1 mRNA]; Triprolidine inhibits the reaction [[Histamine results in increased activity of HRH1 protein] which results in increased abundance of Calcium]; Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]; Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP]]; Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in increased export of Calcium]]; Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in increased metabolism of Phosphatidylinositols]]
HRH1 protein affects the susceptibility to Histamine
[epinastine binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Histamine; [Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine; [Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein; [Histamine results in increased activity of HRH1 protein] which affects the transport of Potassium; [Tripelennamine binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Histamine; Histamine binds to and results in increased activity of HRH1 protein; Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine]; Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein]; Ro 31-8220 inhibits the reaction [Histamine results in increased expression of HRH1 mRNA]; Triprolidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein]		 CTD PMID:2419744 PMID:11238657 PMID:11306145 PMID:11527950 PMID:12095164 More... NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455 		JBrowse link
G Hrh2 histamine receptor H 2 multiple interactions
increases activity
affects localization
affects expression		 ISO
EXP		 [Cimetidine binds to and results in decreased activity of HRH2 protein] results in decreased susceptibility to [Histamine co-treated with [Oxygen deficiency co-treated with Oxygen]]; [Histamine affects the localization of HRH2 protein] which affects the degradation of HRH2 protein; [Histamine binds to and results in increased activity of HRH2 protein] which results in decreased expression of IFNG mRNA; [Histamine binds to and results in increased activity of HRH2 protein] which results in increased abundance of Cyclic AMP; [Histamine binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA; [Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12A protein; [Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12B protein; [tiotidine inhibits the reaction [Histamine binds to and results in increased activity of HRH2 protein]] which results in decreased expression of CD40 protein; [tiotidine inhibits the reaction [Histamine binds to and results in increased activity of HRH2 protein]] which results in decreased expression of PTPRC protein; Burimamide inhibits the reaction [[Cyclic AMP binds to and results in increased activity of HRH2 protein] which results in increased abundance of Histamine]; Burimamide inhibits the reaction [Histamine binds to and results in increased activity of HRH2 protein]; Cimetidine inhibits the reaction [HRH2 protein promotes the reaction [Histamine results in increased expression of IL16 protein]]; Cyclic AMP promotes the reaction [[Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12A protein]; Cyclic AMP promotes the reaction [[Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12B protein]; Famotidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA]; Histamine binds to and results in increased activity of HRH2 protein; HRH2 protein affects the reaction [Histamine affects the expression of CD14 protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]; HRH2 protein promotes the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG mRNA]]; HRH2 protein promotes the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]]; HRH2 protein promotes the reaction [Histamine results in decreased expression of IL12A protein]; HRH2 protein promotes the reaction [Histamine results in decreased expression of IL12B protein]; HRH2 protein promotes the reaction [Histamine results in increased expression of IL16 protein]; tiotidine inhibits the reaction [Histamine binds to and results in increased activity of HRH2 protein]
[[thioperamide results in increased abundance of Histamine] which results in increased activity of HRH2 protein] which results in decreased susceptibility to Scopolamine; [Famotidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Histamine; [roxatidine acetate binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Histamine; [thioperamide results in increased abundance of Histamine] which results in increased activity of HRH2 protein; Cimetidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in decreased susceptibility to Scopolamine]; Histamine binds to and results in increased activity of HRH2 protein; Histamine inhibits the reaction [tiotidine binds to HRH2 protein]
HRH2 protein affects the reaction [Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TNF protein]]; HRH2 protein affects the reaction [Histamine results in increased expression of IL18 protein]
Histamine affects the expression of HRH2 protein		 CTD PMID:9187264 PMID:9681472 PMID:9819373 PMID:10569698 PMID:11306145 More... NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631 		JBrowse link
G Hrh3 histamine receptor H3 multiple interactions ISO
EXP		 Histamine binds to and results in increased activity of HRH3 protein
Histamine binds to Hrh3 protein; Histamine inhibits the reaction [N-methylhistamine binds to Hrh3 protein]
[Histamine binds to and results in increased activity of HRH3 protein] which results in increased transport of Calcium; Histamine binds to and results in increased activity of HRH3 protein		 CTD
RGD		 PMID:12706455 PMID:10869375 RGD:632981 NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642 		JBrowse link
G Hrh4 histamine receptor H4 multiple interactions
increases response to substance
increases activity		 ISO 1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine inhibits the reaction [HRH4 protein results in increased susceptibility to Histamine]; [Histamine binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium; [Histamine binds to and results in increased activity of HRH4 protein] which results in increased phosphorylation of MAPK1 protein; [Histamine binds to and results in increased activity of HRH4 protein] which results in increased phosphorylation of MAPK3 protein; [Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12A protein; [Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12B protein; [HRH4 protein results in increased susceptibility to Histamine] which results in decreased expression of CCND1 protein; [HRH4 protein results in increased susceptibility to Histamine] which results in decreased expression of CDK2 protein; [HRH4 protein results in increased susceptibility to Histamine] which results in increased expression of CDKN1A protein; [HRH4 protein results in increased susceptibility to Histamine] which results in increased expression of CDKN1B protein; Histamine binds to and results in increased activity of HRH4 protein; Histamine promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to HRH4 protein]; U 0126 inhibits the reaction [[Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12A protein]; U 0126 inhibits the reaction [[Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12B protein] CTD PMID:11181941 PMID:15843518 PMID:22363581 NCBI chr18:4,166,270...4,182,426
Ensembl chr18:4,166,270...4,246,345 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]; Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]; Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]] CTD PMID:11752121 PMID:12364868 PMID:12538815 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma multiple interactions
affects expression		 ISO [Histamine binds to and results in increased activity of HRH2 protein] which results in decreased expression of IFNG mRNA; [Histamine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA; [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Cimetidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]; Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG mRNA]; Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; HRH2 protein promotes the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG mRNA]]; HRH2 protein promotes the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]]
Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG mRNA]; Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG protein]]
Histamine affects the expression of IFNG protein		 CTD PMID:10569698 PMID:11752121 PMID:12364868 PMID:17346280 PMID:19277450 More... NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; Terfenadine inhibits the reaction [Histamine results in increased expression of IL10 protein] CTD PMID:11752121 PMID:12925206 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12a interleukin 12A multiple interactions
increases expression
decreases expression		 ISO [Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12A protein; [Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12A protein; [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Cyclic AMP promotes the reaction [[Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12A protein]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; HRH2 protein promotes the reaction [Histamine results in decreased expression of IL12A protein]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Ranitidine inhibits the reaction [Histamine results in decreased expression of IL12A protein]; U 0126 inhibits the reaction [[Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12A protein]
Histamine results in increased expression of IL12A protein
Histamine results in decreased expression of IL12A mRNA; Histamine results in decreased expression of IL12A protein		 CTD PMID:9819373 PMID:11752121 PMID:12364868 PMID:15843518 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B decreases expression
increases expression
multiple interactions		 ISO Histamine results in decreased expression of IL12B mRNA; Histamine results in decreased expression of IL12B protein
Histamine results in increased expression of IL12B protein
[Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12B protein; [Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12B protein; [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Cyclic AMP promotes the reaction [[Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12B protein]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; HRH2 protein promotes the reaction [Histamine results in decreased expression of IL12B protein]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Ranitidine inhibits the reaction [Histamine results in decreased expression of IL12B protein]; U 0126 inhibits the reaction [[Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12B protein]		 CTD PMID:9819373 PMID:11752121 PMID:12364868 PMID:15843518 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il16 interleukin 16 multiple interactions
increases expression		 ISO Cimetidine inhibits the reaction [HRH2 protein promotes the reaction [Histamine results in increased expression of IL16 protein]]; HRH2 protein promotes the reaction [Histamine results in increased expression of IL16 protein]; thioperamide inhibits the reaction [Histamine results in increased expression of IL16 protein] CTD PMID:12235264 NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130 		JBrowse link
G Il18 interleukin 18 multiple interactions
increases expression		 ISO [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; [IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]; Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]; Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]; Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]; Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]; Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Histamine results in increased expression of IL18 protein]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]
HRH2 protein affects the reaction [Histamine results in increased expression of IL18 protein]		 CTD PMID:11752121 PMID:12364868 PMID:16723495 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 EXP IL1B protein inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]
Histamine results in increased expression of IL1B mRNA		 CTD PMID:11164953 PMID:36565801 PMID:38348711 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]]
[Histamine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA		 CTD PMID:19277450 PMID:29594315 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il4 interleukin 4 multiple interactions
increases response to substance		 ISO Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 protein]]
IL4 protein results in increased susceptibility to Histamine		 CTD PMID:12370375 PMID:19277450 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO Terfenadine inhibits the reaction [Histamine results in increased expression of IL5 protein] CTD PMID:12925206 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion
increases expression		 ISO Calcimycin inhibits the reaction [Calcium promotes the reaction [Histamine results in increased expression of IL6 protein]]; Calcium promotes the reaction [Histamine results in increased expression of IL6 protein]; Diphenhydramine inhibits the reaction [Histamine results in increased expression of IL6 protein]; Edetic Acid inhibits the reaction [Calcium promotes the reaction [Histamine results in increased expression of IL6 protein]]; fexofenadine inhibits the reaction [Histamine results in increased expression of IL6 protein]; Glycyrrhizic Acid inhibits the reaction [Histamine results in increased expression of IL6 mRNA]; Glycyrrhizic Acid inhibits the reaction [Histamine results in increased secretion of IL6 protein]; HRH1 protein promotes the reaction [Histamine results in increased expression of IL6 protein]; Lipopolysaccharides promotes the reaction [Histamine results in increased expression of IL6 protein]; prolinedithiocarbamate inhibits the reaction [Histamine results in increased expression of IL6 mRNA]; prolinedithiocarbamate inhibits the reaction [Histamine results in increased secretion of IL6 protein]; TNF protein promotes the reaction [Histamine results in increased expression of IL6 protein]
Histamine results in increased expression of IL6 mRNA; Histamine results in increased expression of IL6 protein		 CTD PMID:9657254 PMID:9856766 PMID:11238657 PMID:11336536 PMID:29452068 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itga2 integrin subunit alpha 2 multiple interactions EXP ITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine] CTD PMID:18234883 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481 		JBrowse link
G Kcnq2 potassium voltage-gated channel subfamily Q member 2 multiple interactions ISO Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]]; Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein] CTD PMID:12147327 NCBI chr 3:168,194,776...168,253,831
Ensembl chr 3:168,195,357...168,275,071 		JBrowse link
G Kcnq3 potassium voltage-gated channel subfamily Q member 3 multiple interactions ISO Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]]; Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein] CTD PMID:12147327 NCBI chr 7:97,730,219...98,025,652
Ensembl chr 7:97,730,465...98,025,653 		JBrowse link
G Kng1 kininogen 1 multiple interactions EXP [KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased abundance of Dinoprostone; [KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein; [Serotonin co-treated with Histamine] promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]; Dinoprostone promotes the reaction [Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased abundance of Dinoprostone]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased secretion of CALCA protein]; Flurbiprofen inhibits the reaction [[Serotonin co-treated with Histamine] promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]]; Flurbiprofen inhibits the reaction [Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]]; Histamine promotes the reaction [[KNG1 protein co-treated with Serotonin] results in increased secretion of CALCA protein]; Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]; ITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine] CTD PMID:11166334 PMID:12791437 PMID:18234883 NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555 		JBrowse link
G Ltc4s leukotriene C4 synthase decreases response to substance ISO LTC4S polymorphism results in decreased susceptibility to Histamine CTD PMID:19862937 NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO
EXP		 [Histamine binds to and results in increased activity of HRH4 protein] which results in increased phosphorylation of MAPK1 protein; Famotidine inhibits the reaction [Histamine results in increased phosphorylation of MAPK1 protein]; Histamine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Hydrogen Peroxide promotes the reaction [Histamine results in increased phosphorylation of MAPK1 protein]; Pyrilamine inhibits the reaction [Histamine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [Histamine results in increased phosphorylation of MAPK1 protein] CTD PMID:11181941 PMID:16009787 PMID:17656145 PMID:21179406 PMID:30310171 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO
EXP		 [Histamine binds to and results in increased activity of HRH4 protein] which results in increased phosphorylation of MAPK3 protein; Famotidine inhibits the reaction [Histamine results in increased phosphorylation of MAPK3 protein]; Histamine results in increased phosphorylation of and results in increased activity of MAPK3 protein; Hydrogen Peroxide promotes the reaction [Histamine results in increased phosphorylation of MAPK3 protein]; Pyrilamine inhibits the reaction [Histamine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [Histamine results in increased phosphorylation of MAPK3 protein] CTD PMID:11181941 PMID:16009787 PMID:17656145 PMID:21179406 PMID:30310171 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP Histamine inhibits the reaction [decamethrin results in decreased nitrosation of MAPK8 protein] CTD PMID:25299849 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions
increases expression
increases secretion		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Histamine results in increased expression of MMP1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Histamine results in increased secretion of MMP1 protein]; EGFR protein affects the reaction [Histamine results in increased secretion of MMP1 protein]; Famotidine inhibits the reaction [Histamine results in increased expression of MMP1 mRNA]; Famotidine inhibits the reaction [Histamine results in increased secretion of MMP1 protein]; RTKI cpd inhibits the reaction [Histamine results in increased expression of MMP1 mRNA]; RTKI cpd inhibits the reaction [Histamine results in increased secretion of MMP1 protein] CTD PMID:9856766 PMID:17656145 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions
increases secretion
increases expression		 ISO Chlorpheniramine inhibits the reaction [Histamine results in increased expression of MUC5AC mRNA]; Chlorpheniramine inhibits the reaction [Histamine results in increased expression of MUC5AC protein]; Glycyrrhizic Acid inhibits the reaction [Histamine results in increased expression of MUC5AC mRNA]; Glycyrrhizic Acid inhibits the reaction [Histamine results in increased secretion of MUC5AC protein]; Niflumic Acid inhibits the reaction [Histamine results in increased expression of MUC5AC mRNA]; Niflumic Acid inhibits the reaction [Histamine results in increased expression of MUC5AC protein]; prolinedithiocarbamate inhibits the reaction [Histamine results in increased expression of MUC5AC mRNA]; prolinedithiocarbamate inhibits the reaction [Histamine results in increased secretion of MUC5AC protein]
Histamine results in increased expression of MUC5AC mRNA; Histamine results in increased expression of MUC5AC protein		 CTD PMID:17622767 PMID:29452068 NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
affects localization		 ISO Histamine promotes the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]; Histamine promotes the reaction [TNF protein affects the localization of NFKB1 protein]
Histamine affects the localization of NFKB1 protein		 CTD PMID:11336536 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases phosphorylation		 ISO Glycyrrhizic Acid inhibits the reaction [Histamine results in increased phosphorylation of NFKBIA protein] CTD PMID:29452068 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP [Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein; Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein]; Triprolidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein] CTD PMID:15167971 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
increases phosphorylation		 ISO
EXP		 [PRKAA1 protein co-treated with PRKAA2 protein] affects the reaction [Histamine results in increased phosphorylation of NOS2 protein]; Deoxyglucose promotes the reaction [STO 609 inhibits the reaction [Histamine results in increased phosphorylation of NOS2 protein]]; STK11 protein promotes the reaction [Histamine results in increased phosphorylation of NOS2 protein]; STO 609 inhibits the reaction [Histamine results in increased phosphorylation of NOS2 protein]
Histamine results in increased expression of NOS2 protein		 CTD PMID:21145922 PMID:36565801 PMID:38348711 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP Histamine inhibits the reaction [decamethrin results in decreased expression of NOS3 protein] CTD PMID:25299849 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Ntf3 neurotrophin 3 multiple interactions
increases expression		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Histamine results in increased expression of NTF3 protein]; [Pyrilamine co-treated with Famotidine co-treated with ciproxifan] inhibits the reaction [Histamine results in increased expression of NTF3 protein]; [Pyrilamine co-treated with Famotidine] inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Cimetidine inhibits the reaction [Histamine results in increased expression of NTF3 protein]; ciproxifan inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Famotidine inhibits the reaction [Histamine results in increased expression of NTF3 protein]; KN 62 inhibits the reaction [Histamine results in increased expression of NTF3 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Pertussis Toxin inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Pyrilamine inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Staurosporine inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Histamine results in increased expression of NTF3 protein]; thioperamide inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Triprolidine inhibits the reaction [Histamine results in increased expression of NTF3 protein]
Histamine results in increased expression of NTF3 mRNA; Histamine results in increased expression of NTF3 protein		 CTD PMID:21276809 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596 		JBrowse link
G Pcna proliferating cell nuclear antigen affects expression ISO Histamine affects the expression of PCNA protein CTD PMID:17729160 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pde4b phosphodiesterase 4B multiple interactions
increases expression		 ISO Cimetidine inhibits the reaction [Histamine results in increased expression of PDE4B mRNA] CTD PMID:11131300 NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696 		JBrowse link
G Pla2g4a phospholipase A2 group 4A multiple interactions
increases expression		 ISO Dexamethasone inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA]; Diphenhydramine inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA]; MK-886 inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA] CTD PMID:9609743 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha increases expression EXP Histamine results in increased expression of PPP3CA protein CTD PMID:30310171 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO [PRKAA1 protein co-treated with PRKAA2 protein] affects the reaction [Histamine results in increased phosphorylation of NOS2 protein] CTD PMID:21145922 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions ISO [PRKAA1 protein co-treated with PRKAA2 protein] affects the reaction [Histamine results in increased phosphorylation of NOS2 protein] CTD PMID:21145922 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543 		JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO epigallocatechin gallate inhibits the reaction [Histamine results in increased phosphorylation of PRKCD protein]; Histamine results in increased phosphorylation of and affects the localization of PRKCD protein; Quercetin inhibits the reaction [Histamine results in increased phosphorylation of and affects the localization of PRKCD protein] CTD PMID:23333628 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions EXP [SC 560 binds to and results in decreased activity of PTGS1 protein] promotes the reaction [Histamine results in increased secretion of Acids] CTD PMID:16299412 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 ISO
EXP		 Histamine promotes the reaction [[TLR2 results in increased expression of PTGS2] which results in increased chemical synthesis of Dinoprostone]; Histamine promotes the reaction [TLR2 results in increased expression of PTGS2]; HRH1 affects the reaction [Histamine promotes the reaction [TLR2 results in increased expression of PTGS2]]
Histamine results in increased expression of PTGS2 mRNA		 CTD PMID:20040740 PMID:36565801 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C multiple interactions ISO [alpha-fluoromethylhistamine results in decreased chemical synthesis of Histamine] which results in decreased expression of PTPRC protein; [tiotidine inhibits the reaction [Histamine binds to and results in increased activity of HRH2 protein]] which results in decreased expression of PTPRC protein; [Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of PTPRC protein CTD PMID:11306145 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
increases expression
increases phosphorylation
multiple interactions		 ISO
EXP		 Histamine affects the localization of RELA protein
Histamine results in increased expression of RELA mRNA
Histamine results in increased phosphorylation of RELA protein
Glycyrrhizic Acid inhibits the reaction [Histamine results in increased phosphorylation of RELA protein]; Histamine promotes the reaction [Lipopolysaccharides affects the localization of RELA protein]; Histamine promotes the reaction [TNF protein affects the localization of RELA protein]; Histamine results in increased activity of [CXCL8 protein binds to RELA protein]		 CTD PMID:9609743 PMID:11336536 PMID:29452068 PMID:38348711 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc18a1 solute carrier family 18 member A1 multiple interactions ISO Histamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin] CTD PMID:8245983 NCBI chr16:20,653,268...20,687,051
Ensembl chr16:20,653,508...20,687,051 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions
affects binding
increases secretion		 EXP
ISO		 Rabeprazole promotes the reaction [SLC18A2 protein results in increased secretion of Histamine]
Histamine binds to SLC18A2 protein		 CTD PMID:7912402 PMID:14642791 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions
increases uptake
increases transport
affects uptake		 EXP
ISO		 Corticosterone inhibits the reaction [SLC22A3 protein results in increased transport of Histamine]; Estradiol inhibits the reaction [SLC22A3 protein results in increased transport of Histamine]; Histamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; pseudoisocyanine inhibits the reaction [SLC22A3 protein results in increased transport of Histamine]; Serotonin inhibits the reaction [SLC22A3 protein results in increased transport of Histamine]
SLC22A3 protein results in increased uptake of Histamine
SLC22A3 protein polymorphism affects the uptake of Histamine		 CTD PMID:12411423 PMID:16928864 PMID:20562519 PMID:20858707 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612 		JBrowse link
G Slc29a4 solute carrier family 29 member 4 increases uptake ISO SLC29A4 protein results in increased uptake of Histamine CTD PMID:20858707 NCBI chr12:11,853,540...11,884,660
Ensembl chr12:11,853,540...11,874,834 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Histamine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Histamine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904 		JBrowse link
G Sod1 superoxide dismutase 1 affects expression ISO Histamine affects the expression of SOD1 protein CTD PMID:17729160 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sst somatostatin multiple interactions EXP SST protein inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]; SST protein inhibits the reaction [GAST protein results in increased secretion of Histamine] CTD PMID:11164953 NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 increases expression ISO Histamine results in increased expression of STAT6 protein CTD PMID:12755381 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495 		JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions
increases phosphorylation		 ISO STK11 protein promotes the reaction [Histamine results in increased abundance of Cyclic GMP]; STK11 protein promotes the reaction [Histamine results in increased phosphorylation of NOS2 protein]
Histamine results in increased phosphorylation of STK11 protein		 CTD PMID:21145922 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315 		JBrowse link
G Taar1 trace-amine-associated receptor 1 increases activity
multiple interactions		 ISO Histamine results in increased activity of TAAR1 protein
[Histamine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP		 CTD PMID:19725810 NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084 		JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions
increases secretion		 ISO
EXP		 Nedocromil inhibits the reaction [TAC1 protein results in increased secretion of Histamine]; Theophylline inhibits the reaction [TAC1 protein results in increased secretion of Histamine]
Dinoprostone promotes the reaction [Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]]; Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]; ITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine]		 CTD PMID:1707400 PMID:9291295 PMID:11166334 PMID:18234883 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO Histamine promotes the reaction [[TLR2 results in increased expression of PTGS2] which results in increased chemical synthesis of Dinoprostone]; Histamine promotes the reaction [TLR2 results in increased expression of PTGS2]; HRH1 affects the reaction [Histamine promotes the reaction [TLR2 results in increased expression of PTGS2]] CTD PMID:20040740 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO
EXP		 Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]; Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Histamine promotes the reaction [TNF protein affects the localization of NFKB1 protein]; Histamine promotes the reaction [TNF protein affects the localization of RELA protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; TNF protein promotes the reaction [Histamine results in increased expression of CCL2 protein]; TNF protein promotes the reaction [Histamine results in increased expression of CXCL8 protein]; TNF protein promotes the reaction [Histamine results in increased expression of IL6 protein]
Histamine results in increased expression of TNF mRNA; Histamine results in increased expression of TNF protein
TNF protein inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]; TNF protein inhibits the reaction [GAST protein results in increased secretion of Histamine]
Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TNF protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TNF protein]]		 CTD PMID:11164953 PMID:11336536 PMID:11752121 PMID:12538815 PMID:14499251 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Ucp2 uncoupling protein 2 decreases secretion
affects secretion
affects abundance		 ISO UCP2 protein results in decreased secretion of Histamine
UCP2 protein affects the secretion of Histamine
UCP2 protein affects the abundance of Histamine		 CTD PMID:19846869 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
G Vip vasoactive intestinal peptide increases secretion EXP VIP protein results in increased secretion of Histamine CTD PMID:11164953 NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216 		JBrowse link
4-methylhistamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO 4-methylhistamine results in decreased expression of CCL2 protein CTD PMID:17507084 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cd14 CD14 molecule multiple interactions ISO [4-methylhistamine binds to and results in increased activity of HRH2 protein] which affects the expression of CD14 protein CTD PMID:14499251 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cd80 Cd80 molecule multiple interactions ISO 4-methylhistamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein] CTD PMID:12538815 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030 		JBrowse link
G Hrh2 histamine receptor H 2 multiple interactions ISO 4-methylhistamine binds to and results in increased activity of HRH2 protein; [4-methylhistamine binds to and results in increased activity of HRH2 protein] which affects the expression of CD14 protein CTD PMID:14499251 NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631 		JBrowse link
G Hrh4 histamine receptor H4 multiple interactions ISO 1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine inhibits the reaction [[4-methylhistamine binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium]; 4-methylhistamine binds to and results in increased activity of HRH4 protein; [4-methylhistamine binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium CTD PMID:17507084 NCBI chr18:4,166,270...4,182,426
Ensembl chr18:4,166,270...4,246,345 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]; 4-methylhistamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein] CTD PMID:11752121 PMID:12364868 PMID:12538815 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma affects expression
multiple interactions		 ISO 4-methylhistamine affects the expression of IFNG protein
4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]		 CTD PMID:11752121 PMID:12364868 PMID:17346280 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO 4-methylhistamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein] CTD PMID:11752121 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12a interleukin 12A multiple interactions ISO 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]] CTD PMID:11752121 PMID:12364868 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]] CTD PMID:11752121 PMID:12364868 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO 4-methylhistamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]; 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]; 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]; 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]; 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of TNF protein] CTD PMID:11752121 PMID:12364868 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]; 4-methylhistamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:11752121 PMID:12538815 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
alpha-methylhistamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gal galanin and GMAP prepropeptide decreases expression EXP alpha-methylhistamine results in decreased expression of GAL mRNA CTD PMID:11956952 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959 		JBrowse link
G Gast gastrin multiple interactions EXP alpha-methylhistamine inhibits the reaction [GAST protein modified form results in increased secretion of Histamine] CTD PMID:2470453 NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496 		JBrowse link
G Hdc histidine decarboxylase decreases expression EXP alpha-methylhistamine results in decreased expression of HDC mRNA CTD PMID:11956952 NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341 		JBrowse link
G Hrh3 histamine receptor H3 multiple interactions
affects binding		 EXP
ISO		 6-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-pyridazin-3-one inhibits the reaction [alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein]]; alpha-methylhistamine binds to and results in increased activity of HRH3 protein; alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein]
alpha-methylhistamine binds to HRH3 protein
6-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-pyridazin-3-one inhibits the reaction [alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein]]; alpha-methylhistamine binds to and results in increased activity of HRH3 protein; alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein]; Endocannabinoids inhibits the reaction [alpha-methylhistamine binds to and results in increased activity of HRH3 protein]; Histamine H3 Antagonists inhibits the reaction [alpha-methylhistamine binds to HRH3 protein]		 CTD PMID:11956952 PMID:21634396 PMID:30102254 PMID:31369746 NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642 		JBrowse link
G Hrh4 histamine receptor H4 multiple interactions ISO [alpha-methylhistamine binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium; alpha-methylhistamine binds to and results in increased activity of HRH4 protein; HRH4 protein promotes the reaction [alpha-methylhistamine results in increased expression of IL16 protein] CTD PMID:11181941 PMID:12235264 NCBI chr18:4,166,270...4,182,426
Ensembl chr18:4,166,270...4,246,345 		JBrowse link
G Ifng interferon gamma affects expression ISO alpha-methylhistamine affects the expression of IFNG protein CTD PMID:17346280 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il16 interleukin 16 multiple interactions
increases expression		 ISO HRH4 protein promotes the reaction [alpha-methylhistamine results in increased expression of IL16 protein] CTD PMID:12235264 NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of IL1B protein]] CTD PMID:31369746 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of IL6 protein]] CTD PMID:31369746 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of NOS2 protein]] CTD PMID:31369746 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of PTGS2 protein]] CTD PMID:31369746 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of RELA protein]] CTD PMID:31369746 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of TNF protein]] CTD PMID:31369746 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
histamine phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F3 coagulation factor III, tissue factor increases expression ISO histamine phosphate results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
N(tele)-methylhistamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aoc1 amine oxidase, copper containing 1 increases metabolic processing ISO AOC1 protein results in increased metabolism of tele-methylhistamine CTD PMID:12072962 NCBI chr 4:77,812,260...77,831,846
Ensembl chr 4:77,812,260...77,831,840 		JBrowse link
G Hrh3 histamine receptor H3 affects binding EXP N(tele)-methylhistamine binds to Hrh3 protein RGD PMID:10869375 RGD:632981 NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        molecular messenger 18659
          neurotransmitter 11681
            histamine 98
              2-methylhistamine 0
              4-methylhistamine 12
              N(alpha)-gamma-L-glutamylhistamine + 0
              N(tele)-methylhistamine 2
              N-acetylhistamine 0
              N-guanylhistamine 0
              N-hydroxyhistamine 0
              alpha-methylhistamine 13
              carcinine 0
              histamine phosphate 1
              testosterone-3-CMO-Hist + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic heterocyclic compound 18868
                                  heteroarene 17151
                                    monocyclic heteroarene 14980
                                      azole 14503
                                        diazole 10770
                                          imidazoles 10220
                                            histamine 98
                                              2-methylhistamine 0
                                              4-methylhistamine 12
                                              N(alpha)-gamma-L-glutamylhistamine + 0
                                              N(tele)-methylhistamine 2
                                              N-acetylhistamine 0
                                              N-guanylhistamine 0
                                              N-hydroxyhistamine 0
                                              alpha-methylhistamine 13
                                              carcinine 0
                                              histamine phosphate 1
                                              testosterone-3-CMO-Hist + 0
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