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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ornithine
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Accession:CHEBI:18257 term browser browse the term
Definition:An alpha-amino acid that is pentanoic acid bearing two amino substituents at positions 2 and 5.
Synonyms:related_synonym: 2,5-Diaminopentanoic acid;   2,5-Diaminovaleric acid;   DL-Ornithine;   Formula=C5H12N2O2;   InChI=1S/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9);   InChIKey=AHLPHDHHMVZTML-UHFFFAOYSA-N;   Orn;   SMILES=NCCCC(N)C(O)=O
 alt_id: CHEBI:7784
 xref: Beilstein:1722296;   CAS:616-07-9;   Gmelin:847696;   KEGG:C01602;   KNApSAcK:C00001384
 xref_mesh: MESH:D009952
 xref: PMID:15449570;   PMID:17190852;   PMID:22264337;   Reaxys:1722296
 cyclic_relationship: is_conjugate_acid_of CHEBI:32964;   is_conjugate_base_of CHEBI:46912


show annotations for term's descendants           Sort by:
ornithine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Ornithine; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Ornithine] CTD PMID:39172838 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Egf epidermal growth factor multiple interactions EXP [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Ornithine; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Ornithine] CTD PMID:22689575 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Psen1 presenilin 1 multiple interactions ISO [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Ornithine; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Ornithine] CTD PMID:39172838 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
rhodotorulic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases activity		 ISO Calcium Chloride inhibits the reaction [rhodotorulic acid results in decreased activity of MMP2 protein]; ferric chloride inhibits the reaction [rhodotorulic acid results in decreased activity of MMP2 protein] CTD PMID:10086886 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
S-methyl-L-thiocitrulline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 multiple interactions EXP S-methylthiocitrulline inhibits the reaction [EDN1 protein results in increased abundance of Nitric Oxide] CTD PMID:16380457 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
decreases activity		 EXP
ISO		 [S-methylthiocitrulline results in decreased activity of NOS1 protein] which affects the abundance of Sodium
[S-methylthiocitrulline results in decreased activity of NOS1 protein] which affects the susceptibility to Methamphetamine		 CTD PMID:11006970 PMID:12511180 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions EXP S-methylthiocitrulline inhibits the reaction [Methamphetamine results in decreased activity of SLC18A2 protein]; S-methylthiocitrulline inhibits the reaction [Methamphetamine results in decreased expression of SLC18A2 protein] CTD PMID:17683483 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325 		JBrowse link
sinefungin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnmt1 DNA methyltransferase 1 decreases activity ISO sinefungin results in decreased activity of DNMT1 protein CTD PMID:23671287 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha decreases activity ISO sinefungin results in decreased activity of DNMT3A protein CTD PMID:23671287 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19917
    role 19887
      biological role 19885
        biochemical role 19569
          metabolite 19577
            eukaryotic metabolite 19378
              algal metabolite 16157
                ornithine 9
                  D-ornithine + 0
                  L-ornithine + 6
                  N(2)-ornithino group + 0
                  N(5)-ornithino group + 0
                  eflornithine + 0
                  ornithine derivative + 4
                  ornithine residue + 0
                  ornithyl group + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19917
    subatomic particle 19915
      composite particle 19915
        hadron 19915
          baryon 19915
            nucleon 19915
              atomic nucleus 19915
                atom 19915
                  main group element atom 19855
                    main group molecular entity 19855
                      s-block molecular entity 19666
                        hydrogen molecular entity 19668
                          hydrides 19176
                            inorganic hydride 18187
                              pnictogen hydride 18177
                                nitrogen hydride 18090
                                  azane 17896
                                    ammonia 17895
                                      organic amino compound 17895
                                        amino acid 16070
                                          non-proteinogenic amino acid 3994
                                            non-proteinogenic alpha-amino acid 3799
                                              ornithine 9
                                                D-ornithine + 0
                                                L-ornithine + 6
                                                N(2)-ornithino group + 0
                                                N(5)-ornithino group + 0
                                                eflornithine + 0
                                                ornithine derivative + 4
                                                ornithine residue + 0
                                                ornithyl group + 0
paths to the root