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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:glutamic acid
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Accession:CHEBI:18237 term browser browse the term
Definition:An α-amino acid that is glutaric acid bearing a single amino substituent at position 2.
Synonyms:related_synonym: 2-Aminoglutaric acid;   2-aminopentanedioic acid;   DL-Glutamic acid;   DL-Glutaminic acid;   E;   Glu;   Glutamate;   Glutaminic acid;   Glutaminsaeure
 alt_id: CHEBI:24314;   CHEBI:5431
 xref: CAS:617-65-2;   Gmelin:101971;   KNApSAcK:C00001358;   KNApSAcK:C00019577;   Reaxys:1723799;   kegg.compound:C00302;   kegg.drug:D04341;   pubmed:15739367;   pubmed:17190852;   pubmed:24616376;   pubmed:24984001;   wikipedia.en:Glutamic_acid
 chemrof_formula: C5H9NO4
 chemrof_inchi: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)
 chemrof_smiles: NC(CCC(=O)O)C(=O)O
 chemrof_inchikey: WHUUTDBJXJRKMK-UHFFFAOYSA-N
 cyclic_relationship: is_conjugate_acid_of CHEBI:14321


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glutamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 decreases expression EXP Glutamate decreases expression of Gria1 protein in interneurons, medium spiny neurons RGD PMID:12390532 RGD:405649864 NCBI chr10:41,710,540...42,030,105
Ensembl chr10:41,711,080...42,030,309 		JBrowse link
L-glutamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
increases activity 		ISO dihydroactinidiolide inhibits the reaction [Glutamic Acid results in increased activity of ACHE protein] CTD PMID:33617922 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions
increases expression 		ISO gastrodin inhibits the reaction [Glutamic Acid results in increased expression of ACSL4 protein] CTD PMID:31698019 NCBI chr  X:110,739,633...110,803,416
Ensembl chr  X:110,739,648...110,803,261 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation 		ISO 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide co-treated with Glutamic Acid] results in increased phosphorylation of AKT1 protein]; 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [[cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with Glutamic Acid] results in increased phosphorylation of AKT1 protein]; 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [[JZL 184 co-treated with Glutamic Acid] results in increased phosphorylation of AKT1 protein]; [3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide co-treated with Glutamic Acid] results in increased phosphorylation of AKT1 protein; [cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with Glutamic Acid] results in increased phosphorylation of AKT1 protein; [JZL 184 co-treated with Glutamic Acid] results in increased phosphorylation of AKT1 protein; AM 251 inhibits the reaction [[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide co-treated with Glutamic Acid] results in increased phosphorylation of AKT1 protein]; AM 251 inhibits the reaction [[cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with Glutamic Acid] results in increased phosphorylation of AKT1 protein]; AM 251 inhibits the reaction [[JZL 184 co-treated with Glutamic Acid] results in increased phosphorylation of AKT1 protein]; CNR1 protein affects the reaction [Glutamic Acid results in increased phosphorylation of AKT1 protein]; GRM5 protein affects the reaction [[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide co-treated with Glutamic Acid] results in increased phosphorylation of AKT1 protein]; GRM5 protein affects the reaction [[cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with Glutamic Acid] results in increased phosphorylation of AKT1 protein]; GRM5 protein affects the reaction [[JZL 184 co-treated with Glutamic Acid] results in increased phosphorylation of AKT1 protein]; GRM5 protein affects the reaction [Glutamic Acid results in increased phosphorylation of AKT1 protein] CTD PMID:27543109 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Glutamic Acid; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Glutamic Acid] CTD PMID:39172838 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971 		JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha decreases expression EXP Glutamic Acid results in decreased expression of ARHGDIA mRNA CTD PMID:25797319 NCBI chr10:106,352,858...106,356,347
Ensembl chr10:106,353,491...106,356,347 		JBrowse link
G Atf4 activating transcription factor 4 increases expression
multiple interactions 		EXP Glutamic Acid results in increased expression of ATF4 protein
sinapinic acid inhibits the reaction [Glutamic Acid results in increased expression of ATF4 protein] 		CTD PMID:39615638 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions
increases expression 		EXP shikonin inhibits the reaction [Glutamic Acid results in increased expression of ATF6 protein] CTD PMID:35028790 NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression 		ISO
EXP 		dihydroactinidiolide inhibits the reaction [Glutamic Acid results in increased expression of BAX protein]
[Enzyme Activators results in increased activity of EIF2AK3 protein] inhibits the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased expression of BAX protein]]; Glutamic Acid results in increased expression of and affects the localization of BAX protein; shikonin inhibits the reaction [Glutamic Acid results in increased expression of and affects the localization of BAX protein]; ursodoxicoltaurine inhibits the reaction [Glutamic Acid results in increased expression of BAX protein] 		CTD PMID:33617922 PMID:35028790 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions 		EXP
ISO 		Glutamic Acid results in decreased expression of BCL2 protein
1,3-benzothiazol-2-yl(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile promotes the reaction [shikonin inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein]]; Memantine analog inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein]; Memantine inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein]; MKC8866 promotes the reaction [shikonin inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein]]; shikonin inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein]; ursodoxicoltaurine inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein]; ursodoxicoltaurine inhibits the reaction [shikonin inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein]]
dihydroactinidiolide inhibits the reaction [Glutamic Acid results in decreased expression of BCL2 protein] 		CTD PMID:32092300 PMID:33617922 PMID:35028790 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G C1qb complement C1q B chain increases expression EXP Glutamic Acid results in increased expression of C1QB mRNA CTD PMID:7870303 NCBI chr 5:154,402,276...154,407,827
Ensembl chr 5:154,402,279...154,407,840 		JBrowse link
G Casp12 caspase 12 multiple interactions EXP [Enzyme Activators results in increased activity of EIF2AK3 protein] inhibits the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased cleavage of CASP12 protein]]; Glutamic Acid results in increased expression of and results in increased cleavage of CASP12 protein; shikonin inhibits the reaction [Glutamic Acid results in increased expression of and results in increased cleavage of CASP12 protein] CTD PMID:35028790 NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression
increases cleavage 		ISO
EXP 		Dronabinol inhibits the reaction [Glutamic Acid results in increased activity of CASP3 protein]
Glutamic Acid results in increased expression of CASP3 protein
[Glutamic Acid co-treated with malic acid co-treated with Ubiquinone] inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; [Glutamic Acid co-treated with malic acid] inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; dihydroactinidiolide inhibits the reaction [Glutamic Acid results in increased expression of CASP3 protein]
schizandrin inhibits the reaction [Glutamic Acid results in increased expression of CASP3 protein]; shikonin inhibits the reaction [Glutamic Acid results in increased expression of CASP3 protein modified form]; sinapinic acid inhibits the reaction [Glutamic Acid results in increased cleavage of CASP3 protein]
Glutamic Acid results in increased expression of CASP3 protein; Glutamic Acid results in increased expression of CASP3 protein modified form 		CTD PMID:18490855 PMID:24732427 PMID:27654887 PMID:33617922 PMID:35028790 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp9 caspase 9 increases expression
multiple interactions 		EXP Glutamic Acid results in increased expression of CASP9 protein
schizandrin inhibits the reaction [Glutamic Acid results in increased expression of CASP9 protein] 		CTD PMID:18490855 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Clu clusterin increases expression EXP Glutamic Acid results in increased expression of CLU mRNA CTD PMID:7870303 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860 		JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions ISO CNR1 protein affects the reaction [Glutamic Acid results in increased phosphorylation of AKT1 protein]; CNR1 protein affects the reaction [Glutamic Acid results in increased phosphorylation of MAPK1 protein]; CNR1 protein affects the reaction [Glutamic Acid results in increased phosphorylation of MAPK3 protein] CTD PMID:27543109 NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:53,204,260...53,239,252 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression 		EXP [Enzyme Activators results in increased activity of EIF2AK3 protein] inhibits the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased expression of DDIT3 protein]]; shikonin inhibits the reaction [Glutamic Acid results in increased expression of DDIT3 protein]; sinapinic acid inhibits the reaction [Glutamic Acid results in increased expression of DDIT3 protein] CTD PMID:35028790 PMID:39615638 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation
multiple interactions 		EXP Glutamic Acid results in increased phosphorylation of EIF2AK3 protein
[Enzyme Activators results in increased activity of EIF2AK3 protein] inhibits the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased cleavage of CASP12 protein]]; [Enzyme Activators results in increased activity of EIF2AK3 protein] inhibits the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased expression of BAX protein]]; [Enzyme Activators results in increased activity of EIF2AK3 protein] inhibits the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased expression of DDIT3 protein]]; GSK2656157 promotes the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased phosphorylation of EIF2AK3 protein]]; shikonin inhibits the reaction [Glutamic Acid results in increased phosphorylation of EIF2AK3 protein]; ursodoxicoltaurine inhibits the reaction [Glutamic Acid results in increased phosphorylation of EIF2AK3 protein]; ursodoxicoltaurine promotes the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased phosphorylation of EIF2AK3 protein]] 		CTD PMID:35028790 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions
increases phosphorylation 		EXP GSK2656157 promotes the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased phosphorylation of EIF2S1 protein]]; shikonin inhibits the reaction [Glutamic Acid results in increased phosphorylation of EIF2S1 protein]; ursodoxicoltaurine inhibits the reaction [Glutamic Acid results in increased phosphorylation of EIF2S1 protein]; ursodoxicoltaurine promotes the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased phosphorylation of EIF2S1 protein]] CTD PMID:35028790 NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions
increases phosphorylation 		EXP shikonin inhibits the reaction [Glutamic Acid results in increased phosphorylation of ERN1 protein] CTD PMID:35028790 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791 		JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions ISO [GAD1 protein binds to Pyridoxal Phosphate] which binds to and results in increased metabolism of Glutamic Acid CTD PMID:35151785 NCBI chr 3:75,777,260...75,818,099
Ensembl chr 3:75,777,534...75,818,759 		JBrowse link
G Gad2 glutamate decarboxylase 2 multiple interactions ISO [GAD2 protein binds to Pyridoxal Phosphate] which binds to and results in increased metabolism of Glutamic Acid CTD PMID:35151785 NCBI chr17:89,671,718...89,734,246
Ensembl chr17:89,671,716...89,941,089 		JBrowse link
G Got1l1 glutamic-oxaloacetic transaminase 1-like 1 affects abundance ISO GOT1L1 protein affects the abundance of Glutamic Acid CTD PMID:25287256 NCBI chr16:71,563,562...71,576,446
Ensembl chr16:71,563,534...71,570,468 		JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions
decreases expression 		ISO gastrodin inhibits the reaction [Glutamic Acid results in decreased expression of GPX4 mRNA]; gastrodin inhibits the reaction [Glutamic Acid results in decreased expression of GPX4 protein]
Glutamic Acid results in decreased expression of GPX4 mRNA; Glutamic Acid results in decreased expression of GPX4 protein 		CTD PMID:31698019 NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629 		JBrowse link
G Grm5 glutamate metabotropic receptor 5 affects response to substance
multiple interactions 		ISO GRM5 protein affects the susceptibility to Glutamic Acid
GRM5 protein affects the reaction [[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide co-treated with Glutamic Acid] results in increased phosphorylation of AKT1 protein]; GRM5 protein affects the reaction [[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]; GRM5 protein affects the reaction [[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; GRM5 protein affects the reaction [[cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with Glutamic Acid] results in increased phosphorylation of AKT1 protein]; GRM5 protein affects the reaction [[cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]; GRM5 protein affects the reaction [[cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; GRM5 protein affects the reaction [[JZL 184 co-treated with Glutamic Acid] results in increased phosphorylation of AKT1 protein]; GRM5 protein affects the reaction [[JZL 184 co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]; GRM5 protein affects the reaction [[JZL 184 co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; GRM5 protein affects the reaction [Glutamic Acid results in increased phosphorylation of AKT1 protein]; GRM5 protein affects the reaction [Glutamic Acid results in increased phosphorylation of MAPK1 protein]; GRM5 protein affects the reaction [Glutamic Acid results in increased phosphorylation of MAPK3 protein] 		CTD PMID:27543109 NCBI chr 1:150,722,711...151,297,585
Ensembl chr 1:150,733,678...151,296,649 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Memantine analog inhibits the reaction [Glutamic Acid results in decreased phosphorylation of and results in increased activity of GSK3B protein]]; Glutamic Acid results in decreased phosphorylation of and results in increased activity of GSK3B protein; Memantine analog inhibits the reaction [Glutamic Acid results in decreased phosphorylation of and results in increased activity of GSK3B protein] CTD PMID:32092300 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression 		ISO gastrodin inhibits the reaction [Glutamic Acid results in decreased expression of HMOX1 protein]
[dihydroactinidiolide co-treated with Glutamic Acid] results in increased expression of HMOX1 mRNA 		CTD PMID:31698019 PMID:33617922 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 decreases expression EXP Glutamic Acid results in decreased expression of HSD17B10 mRNA CTD PMID:25797319 NCBI chr  X:24,568,551...24,571,012
Ensembl chr  X:24,568,551...24,574,681 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions 		EXP Glutamic Acid results in increased expression of HSPA5 protein
sinapinic acid inhibits the reaction [Glutamic Acid results in increased expression of HSPA5 protein] 		CTD PMID:39615638 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression 		EXP sinapinic acid inhibits the reaction [Glutamic Acid results in increased expression of IL1B protein] CTD PMID:39615638 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Itpr3 inositol 1,4,5-trisphosphate receptor, type 3 affects metabolic processing ISO ITPR3 mutant form affects the metabolism of Glutamic Acid CTD PMID:32853769 NCBI chr20:5,138,553...5,204,189
Ensembl chr20:5,118,834...5,204,184 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 multiple interactions ISO [TNF protein co-treated with Glutamic Acid] results in increased activity of MAP3K7 protein CTD PMID:36912451 NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:51,154,352...51,212,012 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation 		EXP
ISO 		[bisphenol A co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein; [Dihydrotestosterone co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein; [Estradiol co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein; afimoxifene inhibits the reaction [[bisphenol A co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]; bisphenol A inhibits the reaction [[Dihydrotestosterone co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]; bisphenol A inhibits the reaction [[Estradiol co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]; Flutamide inhibits the reaction [[bisphenol A co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]
Glutamic Acid results in increased phosphorylation of MAPK1 protein
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]; 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [[cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]; 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [[JZL 184 co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]; [3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein; [cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein; [JZL 184 co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein; AM 251 inhibits the reaction [[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]; AM 251 inhibits the reaction [[cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]; AM 251 inhibits the reaction [[JZL 184 co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]; CNR1 protein affects the reaction [Glutamic Acid results in increased phosphorylation of MAPK1 protein]; GRM5 protein affects the reaction [[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]; GRM5 protein affects the reaction [[cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]; GRM5 protein affects the reaction [[JZL 184 co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]; GRM5 protein affects the reaction [Glutamic Acid results in increased phosphorylation of MAPK1 protein] 		CTD PMID:27543109 PMID:30707916 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation 		EXP
ISO 		[bisphenol A co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein; [Dihydrotestosterone co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein; [Estradiol co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein; afimoxifene inhibits the reaction [[bisphenol A co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; bisphenol A inhibits the reaction [[Dihydrotestosterone co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; bisphenol A inhibits the reaction [[Estradiol co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; Flutamide inhibits the reaction [[bisphenol A co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [[cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [[JZL 184 co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; [3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein; [cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein; [JZL 184 co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein; AM 251 inhibits the reaction [[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; AM 251 inhibits the reaction [[cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; AM 251 inhibits the reaction [[JZL 184 co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; CNR1 protein affects the reaction [Glutamic Acid results in increased phosphorylation of MAPK3 protein]; GRM5 protein affects the reaction [[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; GRM5 protein affects the reaction [[cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; GRM5 protein affects the reaction [[JZL 184 co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; GRM5 protein affects the reaction [Glutamic Acid results in increased phosphorylation of MAPK3 protein] 		CTD PMID:27543109 PMID:30707916 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation 		EXP shikonin inhibits the reaction [Glutamic Acid results in increased phosphorylation of MAPK8 protein] CTD PMID:35028790 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions 		EXP Glutamic Acid results in increased phosphorylation of MAPK9 protein
shikonin inhibits the reaction [Glutamic Acid results in increased phosphorylation of MAPK9 protein] 		CTD PMID:35028790 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228 		JBrowse link
G Nckap1 NCK-associated protein 1 decreases expression EXP Glutamic Acid results in decreased expression of NCKAP1 mRNA CTD PMID:25797319 NCBI chr 3:85,824,333...85,898,748
Ensembl chr 3:85,824,336...85,898,797 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization
multiple interactions 		ISO Glutamic Acid affects the localization of NFE2L2 protein
gastrodin affects the reaction [Glutamic Acid affects the localization of NFE2L2 protein]
[dihydroactinidiolide co-treated with Glutamic Acid] results in increased expression of NFE2L2 mRNA 		CTD PMID:31698019 PMID:33617922 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Palld palladin, cytoskeletal associated protein increases expression EXP Glutamic Acid results in increased expression of PALLD mRNA CTD PMID:25797319 NCBI chr16:33,238,943...33,632,236
Ensembl chr16:33,238,956...33,632,232 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO [Glutamic Acid co-treated with asiatic acid] results in increased expression of PPARGC1A protein CTD PMID:22447225 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213 		JBrowse link
G Ppia peptidylprolyl isomerase A decreases expression EXP Glutamic Acid results in decreased expression of PPIA mRNA CTD PMID:25797319 NCBI chr14:85,491,223...85,496,884
Ensembl chr14:85,492,484...85,497,115 		JBrowse link
G Prdx6 peroxiredoxin 6 decreases expression ISO Glutamic Acid results in decreased expression of PRDX6 mRNA; Glutamic Acid results in decreased expression of PRDX6 protein CTD PMID:26447207 NCBI chr13:76,062,082...76,072,631
Ensembl chr13:76,061,554...76,072,657 		JBrowse link
G Psen1 presenilin 1 multiple interactions ISO [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Glutamic Acid; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Glutamic Acid] CTD PMID:39172838 NCBI chr 6:109,054,160...109,106,191
Ensembl chr 6:109,060,352...109,106,189 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions 		ISO Glutamic Acid results in increased expression of PTGS2 mRNA; Glutamic Acid results in increased expression of PTGS2 protein
gastrodin inhibits the reaction [Glutamic Acid results in increased expression of PTGS2 mRNA]; gastrodin inhibits the reaction [Glutamic Acid results in increased expression of PTGS2 protein] 		CTD PMID:31698019 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 multiple interactions
increases expression 		EXP geissoschizine methylether promotes the reaction [Glutamic Acid results in increased expression of SLC3A2 mRNA]; hirsuteine promotes the reaction [Glutamic Acid results in increased expression of SLC3A2 mRNA]; hirsutine promotes the reaction [Glutamic Acid results in increased expression of SLC3A2 mRNA]; procyanidin B1 promotes the reaction [Glutamic Acid results in increased expression of SLC3A2 mRNA]; Yi-Gan San promotes the reaction [Glutamic Acid results in increased expression of SLC3A2 mRNA] CTD PMID:25551766 NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:215,033,601...215,048,064 		JBrowse link
G Slc40a1 solute carrier family 40 member 1 multiple interactions
decreases expression 		ISO gastrodin inhibits the reaction [Glutamic Acid results in decreased expression of SLC40A1 protein] CTD PMID:31698019 NCBI chr 9:55,525,457...55,633,463
Ensembl chr 9:55,525,532...55,543,460 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression
multiple interactions 		EXP Glutamic Acid results in increased expression of SLC7A11 mRNA
geissoschizine methylether promotes the reaction [Glutamic Acid results in increased expression of SLC7A11 mRNA]; hirsuteine promotes the reaction [Glutamic Acid results in increased expression of SLC7A11 mRNA]; hirsutine promotes the reaction [Glutamic Acid results in increased expression of SLC7A11 mRNA]; procyanidin B1 promotes the reaction [Glutamic Acid results in increased expression of SLC7A11 mRNA]; Yi-Gan San promotes the reaction [Glutamic Acid results in increased expression of SLC7A11 mRNA] 		CTD PMID:25551766 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695 		JBrowse link
G Snca synuclein alpha multiple interactions EXP Glutamic Acid inhibits the reaction [zolmitriptan inhibits the reaction [Reserpine results in increased expression of SNCA protein]] CTD PMID:38229316 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression 		ISO
EXP 		[TNF protein co-treated with Glutamic Acid] results in increased activity of MAP3K7 protein
sinapinic acid inhibits the reaction [Glutamic Acid results in increased expression of TNF protein] 		CTD PMID:36912451 PMID:39615638 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 multiple interactions
increases activity 		ISO 9-phenanthrol inhibits the reaction [Glutamic Acid results in increased activity of TRPM4 protein]
9-phenanthrol inhibits the reaction [Glutamic Acid results in increased activity of TRPM4 protein]; YWHAG protein affects the reaction [Glutamic Acid results in increased activity of TRPM4 protein] 		CTD PMID:25047048 NCBI chr 1:104,918,462...104,949,453
Ensembl chr 1:104,918,462...104,948,653 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 increases expression EXP Glutamic Acid results in increased expression of VDAC1 mRNA CTD PMID:25797319 NCBI chr10:37,029,377...37,060,542
Ensembl chr10:37,023,145...37,060,541 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions
increases expression 		EXP MKC8866 promotes the reaction [shikonin inhibits the reaction [Glutamic Acid results in increased expression of XBP1 protein alternative form]]; shikonin inhibits the reaction [Glutamic Acid results in increased expression of XBP1 protein alternative form] CTD PMID:35028790 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706 		JBrowse link
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma multiple interactions ISO YWHAG protein affects the reaction [Glutamic Acid results in increased activity of TRPM4 protein] CTD PMID:25047048 NCBI chr12:26,381,106...26,409,466
Ensembl chr12:26,380,816...26,409,465 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        biochemical role 19888
          metabolite 19624
            fundamental metabolite 3145
              glutamic acid 53
                D-glutamic acid 0
                L-glutamic acid + 52
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            heteroorganic entity 20201
                              organochalcogen compound 19822
                                organooxygen compound 19713
                                  carbon oxoacid 17678
                                    carboxylic acid 17675
                                      amino acid 7910
                                        polar amino acid 212
                                          glutamic acid 53
                                            D-glutamic acid 0
                                            L-glutamic acid + 52
paths to the root