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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:arsenic acid
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Accession:CHEBI:18231 term browser browse the term
Definition:An arsenic oxoacid comprising one oxo group and three hydroxy groups attached to a central arsenic atom.
Synonyms:exact_synonym: tetraoxoarsenic acid;   trihydrogen tetraoxoarsenate;   trihydroxidooxidoarsenic
 related_synonym: Formula=AsH3O4;   Formula=H3AsO4;   H3AsO4;   InChI=1S/AsH3O4/c2-1(3,4)5/h(H3,2,3,4,5);   InChIKey=DJHGAFSJWGLOIV-UHFFFAOYSA-N;   Orthoarsenic acid;   SMILES=O[As](O)(O)=O;   [AsO(OH)3];   arsoric acid
 alt_id: CHEBI:22631;   CHEBI:2843
 xref: CAS:7778-39-4;   Gmelin:2294;   KEGG:C01478
 xref_mesh: MESH:C025657
 xref: PPDB:2913
 cyclic_relationship: is_conjugate_acid_of CHEBI:22629;   is_conjugate_acid_of CHEBI:48600


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arsenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases response to substance ISO ABCC1 protein results in decreased susceptibility to arsenic acid; ABCC1 results in decreased susceptibility to arsenic acid CTD PMID:7954421 PMID:21918036 PMID:29752257 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO AIFM1 protein inhibits the reaction [arsenic acid results in decreased reduction of Glutathione]; AIFM1 protein promotes the reaction [arsenic acid results in decreased reduction of Adenine Nucleotides] CTD PMID:15316071 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO arsenic acid results in decreased phosphorylation of AKT1 protein CTD PMID:26763397 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alad aminolevulinate dehydratase decreases activity EXP arsenic acid results in decreased activity of ALAD protein CTD PMID:15202869 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G As3mt arsenite methyltransferase affects abundance
affects methylation
affects metabolic processing
affects secretion
multiple interactions		 ISO
EXP		 AS3MT protein affects the abundance of arsenic acid
AS3MT protein affects the methylation of arsenic acid
AS3MT protein affects the metabolism of arsenic acid
AS3MT protein affects the secretion of arsenic acid
Glutathione affects the reaction [AS3MT protein affects the metabolism of arsenic acid]		 CTD PMID:15606138 PMID:19691357 NCBI chr 1:245,595,939...245,628,921
Ensembl chr 1:245,596,108...245,627,872 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO arsenic acid results in increased expression of BCL2 mRNA CTD PMID:8946558 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp12 caspase 12 increases activity EXP arsenic acid results in increased activity of CASP12 protein CTD PMID:18226606 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Cat catalase multiple interactions EXP [CAT protein results in decreased oxidation of arsenite] which results in decreased chemical synthesis of arsenic acid CTD PMID:18619986 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions
increases expression		 ISO Dietary Fats promotes the reaction [arsenic acid results in increased expression of COL3A1 mRNA] CTD PMID:18296743 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO arsenic acid results in increased expression of CXCL1 mRNA CTD PMID:18296743 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Dpp4 dipeptidylpeptidase 4 decreases expression ISO arsenic acid results in decreased expression of DPP4 mRNA CTD PMID:29355690 NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901 		JBrowse link
G Egfr epidermal growth factor receptor increases phosphorylation
multiple interactions		 ISO arsenic acid results in increased phosphorylation of EGFR protein
EGFR protein affects the reaction [arsenic acid results in increased activity of MAPK1 protein]; EGFR protein affects the reaction [arsenic acid results in increased activity of MAPK3 protein]		 CTD PMID:14674888 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Elk1 ETS transcription factor ELK1 increases activity EXP arsenic acid results in increased activity of ELK1 protein CTD PMID:10445758 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713 		JBrowse link
G Folr2 folate receptor beta decreases response to substance ISO FOLR2 results in decreased susceptibility to arsenic acid CTD PMID:14745917 NCBI chr 1:156,200,044...156,218,380
Ensembl chr 1:156,200,060...156,205,724 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP arsenic acid results in increased expression of FOS CTD PMID:10445758 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Foxo1 forkhead box O1 affects localization ISO arsenic acid affects the localization of FOXO1 protein CTD PMID:26763397 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Foxo3 forkhead box O3 affects localization ISO arsenic acid affects the localization of FOXO3 protein CTD PMID:26763397 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Glb1 galactosidase, beta 1 increases activity ISO arsenic acid results in increased activity of GLB1 protein CTD PMID:26763397 NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO arsenic acid results in increased expression of GPX1 mRNA; arsenic acid results in increased expression of GPX1 protein CTD PMID:19429247 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gpx2 glutathione peroxidase 2 decreases expression ISO arsenic acid results in decreased expression of GPX2 mRNA CTD PMID:19429247 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Gpx4 glutathione peroxidase 4 increases expression ISO arsenic acid results in increased expression of GPX4 mRNA; arsenic acid results in increased expression of GPX4 protein CTD PMID:19429247 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Grb2 growth factor receptor bound protein 2 multiple interactions ISO arsenic acid promotes the reaction [SHC1 protein binds to GRB2 protein] CTD PMID:14674888 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 decreases expression EXP arsenic acid analog results in decreased expression of GRIA1 mRNA CTD PMID:19761793 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 decreases expression EXP arsenic acid analog results in decreased expression of GRIA2 mRNA CTD PMID:19761793 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510 		JBrowse link
G Gsto1 glutathione S-transferase omega 1 increases reduction ISO GSTO1 protein results in increased reduction of arsenic acid CTD PMID:16930657 NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP arsenic acid results in increased expression of HMOX1 protein CTD PMID:18226606 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 affects methylation ISO arsenic acid affects the methylation of HSD11B1 gene CTD PMID:26855884 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 increases expression ISO arsenic acid results in increased expression of HSD11B2 mRNA CTD PMID:26855884 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO Dietary Fats promotes the reaction [arsenic acid results in increased expression of IL6 mRNA] CTD PMID:18296743 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 increases activity ISO arsenic acid results in increased activity of MAP2K1 protein CTD PMID:14674888 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 increases activity ISO arsenic acid results in increased activity of MAP2K2 protein CTD PMID:14674888 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity
multiple interactions		 ISO arsenic acid results in increased activity of MAPK1 protein
EGFR protein affects the reaction [arsenic acid results in increased activity of MAPK1 protein]; RTKI cpd inhibits the reaction [arsenic acid results in increased activity of MAPK1 protein]; Suramin inhibits the reaction [arsenic acid results in increased activity of MAPK1 protein]		 CTD PMID:14674888 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases activity		 ISO EGFR protein affects the reaction [arsenic acid results in increased activity of MAPK3 protein]; RTKI cpd inhibits the reaction [arsenic acid results in increased activity of MAPK3 protein]; Suramin inhibits the reaction [arsenic acid results in increased activity of MAPK3 protein] CTD PMID:14674888 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP
ISO		 arsenic acid results in increased expression of MYC
arsenic acid results in increased expression of MYC mRNA		 CTD PMID:10445758 PMID:29355690 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization
multiple interactions		 ISO arsenic acid affects the localization of NFE2L2 protein
Sodium Selenite promotes the reaction [arsenic acid affects the localization of NFE2L2 protein]		 CTD PMID:19429247 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases methylation
increases expression		 ISO arsenic acid results in decreased methylation of NR3C1 gene
arsenic acid results in increased expression of NR3C1 mRNA		 CTD PMID:26855884 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Otc ornithine transcarbamylase increases reduction EXP OTC protein results in increased reduction of arsenic acid CTD PMID:19248796 NCBI chr  X:12,453,834...12,529,954
Ensembl chr  X:12,453,834...12,566,918 		JBrowse link
G Papss1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 multiple interactions ISO PAPSS1 protein binds to and affects the metabolism of arsenic acid CTD PMID:15065880 NCBI chr 2:220,040,343...220,114,399
Ensembl chr 2:220,040,312...220,114,395 		JBrowse link
G Pnp purine nucleoside phosphorylase increases reduction
multiple interactions
increases metabolic processing		 ISO PNP protein results in increased reduction of arsenic acid
[PNP protein results in increased metabolism of arsenic acid] which results in increased chemical synthesis of arsenite		 CTD PMID:12928150 PMID:15929903 NCBI chr15:24,170,607...24,178,269
Ensembl chr15:24,170,602...24,203,986 		JBrowse link
G Selenof selenoprotein F decreases expression ISO arsenic acid results in decreased expression of SELENOF mRNA CTD PMID:19429247 NCBI chr 2:233,642,075...233,674,853
Ensembl chr 2:233,641,932...233,674,846 		JBrowse link
G Selenoh selenoprotein H decreases expression ISO arsenic acid results in decreased expression of SELENOH mRNA CTD PMID:19429247 NCBI chr 3:69,751,850...69,753,417
Ensembl chr 3:69,752,757...69,753,417 		JBrowse link
G Selenoi selenoprotein I decreases expression ISO arsenic acid results in decreased expression of SELENOI mRNA CTD PMID:19429247 NCBI chr 6:26,073,127...26,111,326
Ensembl chr 6:26,072,648...26,111,314 		JBrowse link
G Selenok selenoprotein K decreases expression ISO arsenic acid results in decreased expression of SELENOK mRNA CTD PMID:19429247 NCBI chr16:5,152,066...5,160,648
Ensembl chr16:5,152,066...5,159,188 		JBrowse link
G Selenom selenoprotein M decreases expression ISO arsenic acid results in decreased expression of SELENOM mRNA CTD PMID:19429247 NCBI chr14:78,395,826...78,398,429
Ensembl chr14:78,395,826...78,398,429 		JBrowse link
G Selenos selenoprotein S decreases expression ISO arsenic acid results in decreased expression of SELENOS mRNA CTD PMID:19429247 NCBI chr 1:119,659,779...119,669,546
Ensembl chr 1:119,659,751...119,669,833 		JBrowse link
G Shc1 SHC adaptor protein 1 increases phosphorylation
multiple interactions		 ISO arsenic acid results in increased phosphorylation of SHC1 protein
arsenic acid promotes the reaction [SHC1 protein binds to GRB2 protein]		 CTD PMID:14674888 NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536 		JBrowse link
G Si sucrase-isomaltase decreases expression ISO arsenic acid results in decreased expression of SI mRNA CTD PMID:29355690 NCBI chr 2:157,505,893...157,586,228
Ensembl chr 2:157,506,342...157,585,260 		JBrowse link
G Snca synuclein alpha decreases expression EXP arsenic acid results in decreased expression of SNCA CTD PMID:25639566 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Stk4 serine/threonine kinase 4 increases phosphorylation ISO arsenic acid results in increased phosphorylation of STK4 protein CTD PMID:26763397 NCBI chr 3:152,745,958...152,827,747
Ensembl chr 3:152,745,681...152,827,744 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
increases expression		 ISO Dietary Fats promotes the reaction [arsenic acid results in increased expression of TIMP1 mRNA] CTD PMID:18296743 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO arsenic acid results in increased expression of TIMP2 mRNA CTD PMID:18296743 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Tnf tumor necrosis factor increases secretion
increases expression		 ISO arsenic acid results in increased secretion of TNF protein
arsenic acid results in increased expression of TNF mRNA		 CTD PMID:9548797 PMID:18296743 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO arsenic acid results in increased expression of TRP53 mRNA CTD PMID:8946558 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases activity
increases expression
multiple interactions		 ISO arsenic acid results in increased activity of TXNRD1 protein
arsenic acid results in increased expression of TXNRD1 mRNA; arsenic acid results in increased expression of TXNRD1 protein
Sodium Selenite promotes the reaction [arsenic acid results in increased activity of TXNRD1 protein]		 CTD PMID:19429247 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Vil1 villin 1 decreases expression ISO arsenic acid results in decreased expression of VIL1 mRNA CTD PMID:29355690 NCBI chr 9:75,991,141...76,018,860
Ensembl chr 9:75,991,141...76,018,858 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    chemical entity 19878
      atom 19878
        metalloid atom 15399
          arsenic atom 14690
            arsenic molecular entity 14690
              arsenic oxoacid 4242
                arsenic acid 55
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      chalcogen 19569
                        oxygen atom 19541
                          oxygen molecular entity 19541
                            hydroxides 19347
                              oxoacid 18782
                                pnictogen oxoacid 14977
                                  arsenic oxoacid 4242
                                    arsenic acid 55
paths to the root