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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3-Nitrobenzanthrone
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Accession:CHEBI:181932 term browser browse the term
Synonyms:exact_synonym: 3-nitrobenzo[b]phenalen-7-one
 related_synonym: Formula=C17H9NO3;   InChI=1S/C17H9NO3/c19-17-12-5-2-1-4-10(12)11-8-9-15(18(20)21)13-6-3-7-14(17)16(11)13/h1-9H;   InChIKey=QAJOWHGESRCVLY-UHFFFAOYSA-N;   SMILES=O=C1C=2C3=C(C=4C1=CC=CC4)C=CC([N+]([O-])=O)=C3C=CC2
 xref: CAS:17117-34-9;   Chemspider:2103821;   KEGG:C20824
 xref_mesh: MESH:C117220



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3-Nitrobenzanthrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi3bp ABI family member 3 binding protein increases expression ISO 3-nitrobenzanthrone results in increased expression of ABI3BP mRNA CTD PMID:34036453 NCBI chr11:43,912,187...44,128,888 JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of ADAMTS1 mRNA CTD PMID:34036453 NCBI chr11:38,418,565...38,427,384 JBrowse link
G Adgra2 adhesion G protein-coupled receptor A2 increases expression ISO 3-nitrobenzanthrone results in increased expression of ADGRA2 mRNA CTD PMID:34036453 NCBI chr16:64,932,964...64,971,433 JBrowse link
G Adm2 adrenomedullin 2 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of ADM2 mRNA CTD PMID:34036453 NCBI chr 7:120,393,179...120,394,965 JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO 3-nitrobenzanthrone binds to and results in increased activity of AHR protein CTD PMID:28186253 NCBI chr 6:57,961,423...57,998,901 JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 multiple interactions
increases reduction
ISO [AKR1C1 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of 3-aminobenzanthrone; [AKR1C1 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of N-hydroxy-3-aminobenzanthrone CTD PMID:30406992 NCBI chr17:70,720,397...70,747,285 JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 multiple interactions
increases reduction
ISO [AKR1C2 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of 3-aminobenzanthrone; [AKR1C2 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of N-hydroxy-3-aminobenzanthrone CTD PMID:30406992 NCBI chr17:70,669,684...70,717,935 JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases reduction
multiple interactions
ISO AKR1C3 protein results in increased reduction of 3-nitrobenzanthrone
[AKR1C3 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of 3-aminobenzanthrone; [AKR1C3 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of N-hydroxy-3-aminobenzanthrone
CTD PMID:30406992 NCBI chr17:71,020,884...71,037,779 JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO 3-nitrobenzanthrone results in increased expression of and results in increased phosphorylation of AKT1 protein; EREG protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of AKT1 protein] CTD PMID:34036453 NCBI chr 6:137,534,810...137,555,131 JBrowse link
G Ang angiogenin decreases expression ISO 3-nitrobenzanthrone results in decreased expression of ANG mRNA CTD PMID:34036453 NCBI chr15:24,312,711...24,323,361 JBrowse link
G Apoe apolipoprotein E increases expression ISO 3-nitrobenzanthrone results in increased expression of APOE mRNA CTD PMID:34036453 NCBI chr 1:88,481,889...88,485,816 JBrowse link
G Arap2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of ARAP2 mRNA CTD PMID:34036453 NCBI chr14:50,921,323...51,120,972 JBrowse link
G Areg amphiregulin increases expression ISO 3-nitrobenzanthrone results in increased expression of AREG mRNA CTD PMID:34036453 NCBI chr14:17,256,384...17,265,641 JBrowse link
G Bicc1 BicC family RNA binding protein 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of BICC1 mRNA CTD PMID:34036453 NCBI chr20:17,449,639...17,686,775 JBrowse link
G Bmp4 bone morphogenetic protein 4 increases expression ISO 3-nitrobenzanthrone results in increased expression of BMP4 mRNA CTD PMID:34036453 NCBI chr15:22,098,191...22,113,145 JBrowse link
G Bmper BMP-binding endothelial regulator increases expression ISO 3-nitrobenzanthrone results in increased expression of BMPER mRNA CTD PMID:34036453 NCBI chr 8:30,008,049...30,253,201 JBrowse link
G Bnc2 basonuclin zinc finger protein 2 increases expression ISO 3-nitrobenzanthrone results in increased expression of BNC2 mRNA CTD PMID:34036453 NCBI chr 5:103,724,934...104,061,890 JBrowse link
G Btg1 BTG anti-proliferation factor 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of BTG1 mRNA CTD PMID:34036453 NCBI chr 7:33,228,149...33,230,406 JBrowse link
G Cav1 caveolin 1 increases expression ISO 3-nitrobenzanthrone results in increased expression of CAV1 mRNA CTD PMID:34036453 NCBI chr 4:46,606,538...46,639,616 JBrowse link
G Ccbe1 collagen and calcium binding EGF domains 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of CCBE1 mRNA CTD PMID:34036453 NCBI chr18:61,849,821...62,093,876 JBrowse link
G Cd24 CD24 molecule increases expression ISO 3-nitrobenzanthrone results in increased expression of CD24 mRNA CTD PMID:34036453 NCBI chr20:47,074,353...47,079,662 JBrowse link
G Cd34 CD34 molecule affects expression ISO 3-nitrobenzanthrone affects the expression of CD34 mRNA CTD PMID:34036453 NCBI chr13:109,008,786...109,029,317 JBrowse link
G Cdh1 cadherin 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of CDH1 mRNA; 3-nitrobenzanthrone results in decreased expression of CDH1 protein CTD PMID:34036453 NCBI chr19:51,402,178...51,471,572 JBrowse link
G Cdk14 cyclin-dependent kinase 14 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of CDK14 mRNA CTD PMID:34036453 NCBI chr 4:29,619,237...30,213,651 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO 3-nitrobenzanthrone results in increased expression of CDKN1A protein CTD PMID:25230394 NCBI chr20:7,150,820...7,161,373 JBrowse link
G Chrdl1 chordin-like 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of CHRDL1 mRNA CTD PMID:34036453 NCBI chr  X:106,889,125...106,992,937 JBrowse link
G Cldn3 claudin 3 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of CLDN3 mRNA CTD PMID:34036453 NCBI chr12:27,345,075...27,346,547 JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain decreases expression ISO 3-nitrobenzanthrone results in decreased expression of COL18A1 mRNA CTD PMID:34036453 NCBI chr20:11,474,104...11,582,593 JBrowse link
G Col5a2 collagen type V alpha 2 chain increases expression ISO 3-nitrobenzanthrone results in increased expression of COL5A2 mRNA CTD PMID:34036453 NCBI chr 9:54,940,768...55,090,151 JBrowse link
G Col6a1 collagen type VI alpha 1 chain affects expression ISO 3-nitrobenzanthrone affects the expression of COL6A1 mRNA CTD PMID:34036453 NCBI chr20:11,905,690...11,924,111 JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of CTNNB1 mRNA CTD PMID:34036453 NCBI chr 8:129,517,576...129,544,661 JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 increases expression ISO 3-nitrobenzanthrone results in increased expression of CXCL14 mRNA CTD PMID:19879285 NCBI chr17:8,323,150...8,331,176 JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of CXCR4 mRNA CTD PMID:34036453 NCBI chr13:42,630,383...42,634,288 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO CYP1A1 protein affects the reaction [3-nitrobenzanthrone results in increased abundance of Reactive Oxygen Species]
3-nitrobenzanthrone results in increased expression of CYP1A1 mRNA
CTD PMID:17477947 PMID:25230394 NCBI chr 8:66,991,940...66,998,014 JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO 3-nitrobenzanthrone results in increased expression of CYP1B1 mRNA CTD PMID:34036453 NCBI chr 6:21,093,927...21,103,091 JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 affects expression ISO 3-nitrobenzanthrone affects the expression of DDR2 mRNA CTD PMID:34036453 NCBI chr13:84,726,412...84,851,032 JBrowse link
G Dsc2 desmocollin 2 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of DSC2 mRNA CTD PMID:34036453 NCBI chr18:11,725,466...11,757,591 JBrowse link
G Ecm1 extracellular matrix protein 1 affects expression ISO 3-nitrobenzanthrone affects the expression of ECM1 mRNA CTD PMID:34036453 NCBI chr 2:183,287,491...183,292,729 JBrowse link
G Epcam epithelial cell adhesion molecule decreases expression ISO 3-nitrobenzanthrone results in decreased expression of EPCAM mRNA CTD PMID:34036453 NCBI chr 6:12,633,715...12,649,678 JBrowse link
G Eps8l1 EPS8 signaling adaptor L1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of EPS8L1 mRNA CTD PMID:34036453 NCBI chr 1:69,343,202...69,359,778 JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of ERBB2 mRNA CTD PMID:34036453 NCBI chr10:83,907,491...83,931,365 JBrowse link
G Ereg epiregulin increases expression
multiple interactions
ISO 3-nitrobenzanthrone results in increased expression of EREG mRNA; 3-nitrobenzanthrone results in increased expression of EREG protein
EREG protein affects the reaction [3-nitrobenzanthrone results in increased expression of SOX9 protein]; EREG protein affects the reaction [3-nitrobenzanthrone results in increased expression of TWIST2 protein]; EREG protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of AKT1 protein]; EREG protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of MAPK1 protein]; EREG protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of MAPK3 protein]; EREG protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of STAT3 protein]
CTD PMID:34036453 NCBI chr14:17,311,485...17,325,260 JBrowse link
G Etv4 ETS variant transcription factor 4 increases expression ISO 3-nitrobenzanthrone results in increased expression of ETV4 mRNA CTD PMID:34036453 NCBI chr10:86,706,749...86,721,974 JBrowse link
G F11r F11 receptor decreases expression ISO 3-nitrobenzanthrone results in decreased expression of F11R mRNA CTD PMID:34036453 NCBI chr13:86,406,229...86,429,819 JBrowse link
G Fbln1 fibulin 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of FBLN1 mRNA CTD PMID:34036453 NCBI chr 7:116,310,582...116,390,075 JBrowse link
G Fbln5 fibulin 5 increases expression ISO 3-nitrobenzanthrone results in increased expression of FBLN5 mRNA CTD PMID:34036453 NCBI chr 6:120,899,219...120,977,829 JBrowse link
G Fgf18 fibroblast growth factor 18 affects expression ISO 3-nitrobenzanthrone affects the expression of FGF18 mRNA CTD PMID:34036453 NCBI chr10:17,706,011...17,737,702 JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression ISO 3-nitrobenzanthrone results in increased expression of FGF2 mRNA CTD PMID:34036453 NCBI chr 2:122,164,454...122,218,796 JBrowse link
G Fgf9 fibroblast growth factor 9 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of FGF9 mRNA CTD PMID:34036453 NCBI chr15:32,208,993...32,254,952 JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 increases expression ISO 3-nitrobenzanthrone results in increased expression of FGFR2 mRNA CTD PMID:34036453 NCBI chr 1:194,175,703...194,280,914 JBrowse link
G Flt4 Fms related receptor tyrosine kinase 4 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of FLT4 mRNA CTD PMID:34036453 NCBI chr10:34,414,834...34,455,878 JBrowse link
G Foxo4 forkhead box O4 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of FOXO4 mRNA CTD PMID:34036453 NCBI chr  X:66,385,241...66,392,115 JBrowse link
G Fst follistatin increases expression ISO 3-nitrobenzanthrone results in increased expression of FST mRNA CTD PMID:34036453 NCBI chr 2:47,856,345...47,863,670 JBrowse link
G Gdf6 growth differentiation factor 6 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of GDF6 mRNA CTD PMID:34036453 NCBI chr 5:27,793,561...27,809,884 JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist increases expression ISO 3-nitrobenzanthrone results in increased expression of GREM1 mRNA CTD PMID:34036453 NCBI chr 3:100,512,317...100,524,001 JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 increases expression ISO 3-nitrobenzanthrone results in increased expression of HIPK2 mRNA CTD PMID:34036453 NCBI chr 4:68,399,358...68,586,404 JBrowse link
G Hoxb3 homeo box B3 increases expression ISO 3-nitrobenzanthrone results in increased expression of HOXB3 mRNA CTD PMID:34036453 NCBI chr10:81,258,739...81,314,134 JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 multiple interactions ISO [NAT2 protein co-treated with 3-nitrobenzanthrone] results in increased mutagenesis of HPRT1 gene; [SULT1A1 protein co-treated with 3-nitrobenzanthrone] results in increased mutagenesis of HPRT1 gene CTD PMID:17483118 NCBI chr  X:132,736,175...132,768,149 JBrowse link
G Id2 inhibitor of DNA binding 2 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of ID2 mRNA CTD PMID:34036453 NCBI chr 6:47,469,162...47,470,995 JBrowse link
G Igfbp4 insulin-like growth factor binding protein 4 increases expression ISO 3-nitrobenzanthrone results in increased expression of IGFBP4 mRNA CTD PMID:34036453 NCBI chr10:84,491,471...84,503,487 JBrowse link
G Il15 interleukin 15 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of IL15 mRNA CTD PMID:34036453 NCBI chr19:42,536,160...42,611,349 JBrowse link
G Il18 interleukin 18 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of IL18 mRNA CTD PMID:34036453 NCBI chr 8:59,802,072...59,829,275 JBrowse link
G Il1b interleukin 1 beta affects expression ISO 3-nitrobenzanthrone affects the expression of IL1B mRNA CTD PMID:34036453 NCBI chr 3:137,030,200...137,036,581 JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
increases secretion
ISO 3-nitrobenzanthrone results in increased expression of IL6 mRNA
IL6 protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of MAPK1 protein]; IL6 protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of MAPK3 protein]; IL6 protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of STAT3 protein]
3-nitrobenzanthrone results in increased secretion of IL6 protein
CTD PMID:34036453 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Inhba inhibin subunit beta A increases expression ISO 3-nitrobenzanthrone results in increased expression of INHBA mRNA CTD PMID:34036453 NCBI chr17:53,787,159...53,810,942 JBrowse link
G Irf6 interferon regulatory factor 6 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of IRF6 mRNA CTD PMID:34036453 NCBI chr13:104,672,179...104,691,386 JBrowse link
G Isl1 ISL LIM homeobox 1 affects expression ISO 3-nitrobenzanthrone affects the expression of ISL1 mRNA CTD PMID:34036453 NCBI chr 2:49,813,618...49,823,442 JBrowse link
G Itga1 integrin subunit alpha 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of ITGA1 mRNA CTD PMID:34036453 NCBI chr 2:48,379,181...48,545,336 JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 increases expression ISO 3-nitrobenzanthrone results in increased expression of ITGB1BP1 mRNA CTD PMID:34036453 NCBI chr 6:46,549,994...46,564,735 JBrowse link
G Itgb3 integrin subunit beta 3 affects expression ISO 3-nitrobenzanthrone affects the expression of ITGB3 mRNA CTD PMID:34036453 NCBI chr10:90,009,927...90,067,787 JBrowse link
G Itm2a integral membrane protein 2A affects expression ISO 3-nitrobenzanthrone affects the expression of ITM2A mRNA CTD PMID:34036453 NCBI chr  X:72,486,383...72,492,344 JBrowse link
G Jam2 junctional adhesion molecule 2 affects expression ISO 3-nitrobenzanthrone affects the expression of JAM2 mRNA CTD PMID:34036453 NCBI chr11:37,316,287...37,366,517 JBrowse link
G Jcad junctional cadherin 5 associated increases expression ISO 3-nitrobenzanthrone results in increased expression of JCAD mRNA CTD PMID:34036453 NCBI chr17:53,089,382...53,130,996 JBrowse link
G Krt7 keratin 7 affects expression ISO 3-nitrobenzanthrone affects the expression of KRT7 mRNA CTD PMID:34036453 NCBI chr 7:134,407,626...134,423,787 JBrowse link
G Lad1 ladinin 1 increases expression ISO 3-nitrobenzanthrone results in increased expression of LAD1 mRNA CTD PMID:34036453 NCBI chr13:47,249,605...47,263,967 JBrowse link
G Llgl2 LLGL scribble cell polarity complex component 2 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of LLGL2 mRNA CTD PMID:34036453 NCBI chr10:101,050,978...101,086,527 JBrowse link
G Lum lumican decreases expression ISO 3-nitrobenzanthrone results in decreased expression of LUM mRNA CTD PMID:34036453 NCBI chr 7:34,245,323...34,252,510 JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO 3-nitrobenzanthrone results in increased phosphorylation of MAPK1 protein
EREG protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of MAPK1 protein]; IL6 protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of MAPK1 protein]
CTD PMID:34036453 NCBI chr11:97,462,025...97,529,193 JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO 3-nitrobenzanthrone results in increased phosphorylation of MAPK3 protein
EREG protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of MAPK3 protein]; IL6 protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of MAPK3 protein]
CTD PMID:34036453 NCBI chr 1:190,797,189...190,803,411 JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO 3-nitrobenzanthrone results in increased expression of MET mRNA; 3-nitrobenzanthrone results in increased expression of MET protein CTD PMID:34036453 NCBI chr 4:46,756,823...46,864,041 JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of MMP2 mRNA CTD PMID:34036453 NCBI chr19:30,327,643...30,355,856 JBrowse link
G Myo1d myosin ID affects expression ISO 3-nitrobenzanthrone affects the expression of MYO1D mRNA CTD PMID:34036453 NCBI chr10:65,489,153...65,765,812 JBrowse link
G Myo5c myosin VC decreases expression ISO 3-nitrobenzanthrone results in decreased expression of MYO5C mRNA CTD PMID:34036453 NCBI chr 8:84,870,031...84,946,996 JBrowse link
G Nat1 N-acetyltransferase 1 multiple interactions
increases activity
ISO [NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone
NAT1 protein results in increased activity of 3-nitrobenzanthrone
CTD PMID:15805261 PMID:20545351 NCBI chr16:22,218,217...22,238,516 JBrowse link
G Nat2 N-acetyltransferase 2 multiple interactions
increases activity
increases response to substance
ISO [NAT2 protein co-treated with 3-nitrobenzanthrone] results in increased mutagenesis of HPRT1 gene; [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]; [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]
NAT2 protein results in increased activity of 3-nitrobenzanthrone
NAT2 protein results in increased susceptibility to 3-nitrobenzanthrone
CTD PMID:15805261 PMID:17483118 PMID:20545351 NCBI chr16:26,974,874...27,005,191 JBrowse link
G Ndrg1 N-myc downstream regulated 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of NDRG1 mRNA CTD PMID:34036453 NCBI chr 7:100,573,526...100,614,902 JBrowse link
G Nf1 neurofibromin 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of NF1 mRNA CTD PMID:34036453 NCBI chr10:64,803,986...65,037,086 JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects metabolic processing
affects response to substance
multiple interactions
ISO NFE2L2 protein affects the metabolism of 3-nitrobenzanthrone
NFE2L2 protein affects the susceptibility to 3-nitrobenzanthrone
[NFE2L2 protein affects the metabolism of 3-nitrobenzanthrone] which affects the abundance of 3-aminobenzanthrone
CTD PMID:31746589 NCBI chr 3:81,001,529...81,031,165 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
increases activity
increases metabolic processing
affects binding
multiple interactions
increases reduction
ISO 3-nitrobenzanthrone results in increased expression of NQO1 mRNA
NQO1 protein results in increased activity of 3-nitrobenzanthrone
NQO1 protein results in increased metabolism of 3-nitrobenzanthrone
3-nitrobenzanthrone binds to NQO1 protein
[NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]; [NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; [NQO1 protein co-treated with NADP co-treated with Phosphoadenosine Phosphosulfate co-treated with SULT1A1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; [NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; [NQO1 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of 3-aminobenzanthrone; [NQO1 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of N-hydroxy-3-aminobenzanthrone
CTD PMID:15805261 PMID:20545351 PMID:25230394 PMID:28922594 PMID:30406992 NCBI chr19:52,205,374...52,220,267 JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression ISO 3-nitrobenzanthrone results in increased expression of NR4A1 mRNA CTD PMID:34036453 NCBI chr 7:132,368,399...132,389,300 JBrowse link
G Nrp1 neuropilin 1 increases expression ISO 3-nitrobenzanthrone results in increased expression of NRP1 mRNA CTD PMID:34036453 NCBI chr19:73,256,557...73,411,705 JBrowse link
G Nrp2 neuropilin 2 affects expression ISO 3-nitrobenzanthrone affects the expression of NRP2 mRNA CTD PMID:34036453 NCBI chr 9:71,616,602...71,731,869 JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A decreases expression ISO 3-nitrobenzanthrone results in decreased expression of OAS1 mRNA CTD PMID:34036453 NCBI chr12:35,669,798...35,680,505 JBrowse link
G Pdpn podoplanin decreases expression ISO 3-nitrobenzanthrone results in decreased expression of PDPN mRNA CTD PMID:34036453 NCBI chr 5:155,601,691...155,635,656 JBrowse link
G Pkn1 protein kinase N1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of PKN1 mRNA CTD PMID:34036453 NCBI chr19:41,346,855...41,374,832 JBrowse link
G Plxnd1 plexin D1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of PLXND1 mRNA CTD PMID:34036453 NCBI chr 4:149,002,786...149,043,097 JBrowse link
G Pmp22 peripheral myelin protein 22 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of PMP22 mRNA CTD PMID:34036453 NCBI chr10:48,294,932...48,324,941 JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [POR protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; POR protein results in increased activity of and results in increased reduction of 3-nitrobenzanthrone CTD PMID:20545351 NCBI chr12:26,587,674...26,655,612 JBrowse link
G Ppfibp2 PPFIA binding protein 2 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of PPFIBP2 mRNA CTD PMID:34036453 NCBI chr 1:161,504,774...161,687,339 JBrowse link
G Ppl periplakin decreases expression ISO 3-nitrobenzanthrone results in decreased expression of PPL mRNA CTD PMID:34036453 NCBI chr10:10,450,919...10,496,575 JBrowse link
G Ptx3 pentraxin 3 increases expression ISO 3-nitrobenzanthrone results in increased expression of PTX3 mRNA CTD PMID:34036453 NCBI chr 2:152,797,563...152,803,372 JBrowse link
G Pycard PYD and CARD domain containing decreases expression ISO 3-nitrobenzanthrone results in decreased expression of PYCARD mRNA CTD PMID:34036453 NCBI chr 1:192,032,124...192,033,419 JBrowse link
G Ramp2 receptor activity modifying protein 2 increases expression ISO 3-nitrobenzanthrone results in increased expression of RAMP2 mRNA CTD PMID:34036453 NCBI chr10:86,689,148...86,690,956 JBrowse link
G RT1-Hb-ps1 RT1 class II, locus Hb, pseudogene 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of HLA-DPB1 mRNA CTD PMID:34036453 NCBI chr20:4,775,598...4,779,590 JBrowse link
G Sema3e semaphorin 3E decreases expression ISO 3-nitrobenzanthrone results in decreased expression of SEMA3E mRNA CTD PMID:34036453 NCBI chr 4:20,297,534...20,555,287 JBrowse link
G Sfrp1 secreted frizzled-related protein 1 increases expression ISO 3-nitrobenzanthrone results in increased expression of SFRP1 mRNA CTD PMID:34036453 NCBI chr16:75,278,325...75,316,736 JBrowse link
G Slc37a1 solute carrier family 37 member 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of SLC37A1 mRNA CTD PMID:34036453 NCBI chr20:9,360,501...9,433,895 JBrowse link
G Slit2 slit guidance ligand 2 increases expression ISO 3-nitrobenzanthrone results in increased expression of SLIT2 mRNA CTD PMID:34036453 NCBI chr14:66,829,661...67,168,517 JBrowse link
G Snai2 snail family transcriptional repressor 2 increases expression ISO 3-nitrobenzanthrone results in increased expression of SNAI2 mRNA; 3-nitrobenzanthrone results in increased expression of SNAI2 protein CTD PMID:34036453 NCBI chr11:99,686,934...99,690,349 JBrowse link
G Snai3 snail family transcriptional repressor 3 increases expression ISO 3-nitrobenzanthrone results in increased expression of SNAI3 mRNA CTD PMID:34036453 NCBI chr19:67,425,311...67,437,830 JBrowse link
G Sox9 SRY-box transcription factor 9 increases expression
multiple interactions
ISO 3-nitrobenzanthrone results in increased expression of SOX9 mRNA; 3-nitrobenzanthrone results in increased expression of SOX9 protein
EREG protein affects the reaction [3-nitrobenzanthrone results in increased expression of SOX9 protein]
CTD PMID:34036453 NCBI chr10:98,305,744...98,311,250 JBrowse link
G Spint1 serine peptidase inhibitor, Kunitz type 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of SPINT1 mRNA CTD PMID:34036453 NCBI chr 3:126,685,017...126,697,957 JBrowse link
G Spock3 SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of SPOCK3 mRNA CTD PMID:34036453 NCBI chr16:26,382,895...26,815,943 JBrowse link
G Srf serum response factor increases expression ISO 3-nitrobenzanthrone results in increased expression of SRF mRNA CTD PMID:34036453 NCBI chr 9:21,924,050...21,933,338 JBrowse link
G Srgn serglycin increases expression ISO 3-nitrobenzanthrone results in increased expression of SRGN mRNA CTD PMID:34036453 NCBI chr20:30,985,508...31,022,296 JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of STAT1 mRNA CTD PMID:34036453 NCBI chr 9:56,911,522...56,951,926 JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation
multiple interactions
ISO 3-nitrobenzanthrone results in increased phosphorylation of STAT3 protein
EREG protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of STAT3 protein]; IL6 protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of STAT3 protein]
CTD PMID:34036453 NCBI chr10:86,311,528...86,363,513 JBrowse link
G Sulf1 sulfatase 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of SULF1 mRNA CTD PMID:34036453 NCBI chr 5:6,362,894...6,526,174 JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions
increases response to substance
increases activity
ISO [NQO1 protein co-treated with NADP co-treated with Phosphoadenosine Phosphosulfate co-treated with SULT1A1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; [SULT1A1 protein co-treated with 3-nitrobenzanthrone] results in increased mutagenesis of HPRT1 gene
SULT1A1 protein results in increased susceptibility to 3-nitrobenzanthrone
SULT1A1 protein results in increased activity of 3-nitrobenzanthrone
CTD PMID:15805261 PMID:17483118 PMID:20545351 NCBI chr 1:190,702,592...190,706,112 JBrowse link
G Syne1 spectrin repeat containing nuclear envelope protein 1 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of SYNE1 mRNA CTD PMID:34036453 NCBI chr 1:41,512,146...41,983,382 JBrowse link
G Tcf4 transcription factor 4 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of TCF4 mRNA CTD PMID:34036453 NCBI chr18:65,216,840...65,563,186 JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO 3-nitrobenzanthrone results in increased expression of THBS1 mRNA CTD PMID:34036453 NCBI chr 3:125,510,250...125,525,402 JBrowse link
G Thbs2 thrombospondin 2 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of THBS2 mRNA CTD PMID:34036453 NCBI chr 1:64,343,523...64,372,918 JBrowse link
G Timp4 TIMP metallopeptidase inhibitor 4 affects expression ISO 3-nitrobenzanthrone affects the expression of TIMP4 mRNA CTD PMID:34036453 NCBI chr 4:148,306,021...148,312,558 JBrowse link
G Tjp3 tight junction protein 3 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of TJP3 mRNA CTD PMID:34036453 NCBI chr 7:8,427,650...8,446,279 JBrowse link
G Tnc tenascin C increases expression ISO 3-nitrobenzanthrone results in increased expression of TNC mRNA CTD PMID:34036453 NCBI chr 5:82,391,340...82,476,197 JBrowse link
G Tnfsf12 TNF superfamily member 12 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of TNFSF12 mRNA CTD PMID:34036453 NCBI chr10:54,902,616...54,912,628 JBrowse link
G Tns1 tensin 1 affects expression ISO 3-nitrobenzanthrone affects the expression of TNS1 mRNA CTD PMID:34036453 NCBI chr 9:75,491,886...75,702,853 JBrowse link
G Tom1l1 target of myb1 like 1 membrane trafficking protein decreases expression ISO 3-nitrobenzanthrone results in decreased expression of TOM1L1 mRNA CTD PMID:34036453 NCBI chr10:75,464,577...75,508,304 JBrowse link
G Tp53 tumor protein p53 decreases expression
increases expression
increases mutagenesis
ISO 3-nitrobenzanthrone results in decreased expression of TP53 mRNA; 3-nitrobenzanthrone results in decreased expression of TP53 protein
3-nitrobenzanthrone results in increased expression of TRP53 protein
3-nitrobenzanthrone results in increased mutagenesis of TP53 gene
CTD PMID:18765419 PMID:25230394 PMID:34036453 NCBI chr10:54,798,871...54,810,300 JBrowse link
G Twist1 twist family bHLH transcription factor 1 increases expression
affects expression
ISO 3-nitrobenzanthrone results in increased expression of TWIST1 protein
3-nitrobenzanthrone affects the expression of TWIST1 mRNA
CTD PMID:34036453 NCBI chr 6:50,674,910...50,676,904 JBrowse link
G Twist2 twist family bHLH transcription factor 2 multiple interactions
increases expression
ISO EREG protein affects the reaction [3-nitrobenzanthrone results in increased expression of TWIST2 protein]
3-nitrobenzanthrone results in increased expression of TWIST2 mRNA; 3-nitrobenzanthrone results in increased expression of TWIST2 protein
CTD PMID:34036453 NCBI chr 9:99,822,242...99,866,722 JBrowse link
G Vamp8 vesicle-associated membrane protein 8 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of VAMP8 mRNA CTD PMID:34036453 NCBI chr 4:104,442,383...104,452,884 JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 increases expression ISO 3-nitrobenzanthrone results in increased expression of ZEB1 mRNA CTD PMID:34036453 NCBI chr17:56,644,397...56,811,155 JBrowse link
G Zeb2 zinc finger E-box binding homeobox 2 decreases expression ISO 3-nitrobenzanthrone results in decreased expression of ZEB2 mRNA CTD PMID:34036453 NCBI chr 3:29,214,581...29,344,890 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19869
      biological role 19867
        xenobiotic 18752
          phenanthrenes 305
            3-Nitrobenzanthrone 135
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            organic molecule 19724
                              organic cyclic compound 19516
                                carbocyclic compound 18612
                                  carbopolycyclic compound 17194
                                    carbotricyclic compound 1569
                                      phenanthrenes 305
                                        3-Nitrobenzanthrone 135
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