CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: gamma-tocopherol
Accession: CHEBI:18185
browse the term
Definition: A tocopherol in which the chroman-6-ol core is substituted by methyl groups at positions 7 and 8. It is found particularly in maize (corn) oil and soya bean (soybean) oils.
Synonyms: exact_synonym: (2R)-2,7,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-ol
related_synonym: (2R)-3,4-dihydro-2,7,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol; (2R,4'R,8'R)-gamma-tocopherol; (R,R,R)-gamma-tocopherol; 7,8-dimethyltocol; D-gamma-tocopherol; E308; Formula=C28H48O2; InChI=1S/C28H48O2/c1-20(2)11-8-12-21(3)13-9-14-22(4)15-10-17-28(7)18-16-25-19-26(29)23(5)24(6)27(25)30-28/h19-22,29H,8-18H2,1-7H3/t21-,22-,28-/m1/s1; InChIKey=QUEDXNHFTDJVIY-DQCZWYHMSA-N; RRR-gamma-tocopherol; SMILES=CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2cc(O)c(C)c(C)c2O1
alt_id: CHEBI:10579; CHEBI:12406; CHEBI:24199; MESH:D024504
xref: AGR:IND605428769; AGR:IND607289207; Beilstein:93072; CAS:54-28-4; Chemspider:83708; DrugBank:DB15394; FooDB:FDB002431; HMDB:HMDB0001492; KEGG:C02483; KNApSAcK:C00007365; LIPID_MAPS_instance:LMPR02020065
xref_mesh: MESH:D024505
xref: MetaCyc:GAMA-TOCOPHEROL; PMID:10875465; PMID:1146729; PMID:11811542; PMID:14871472; PMID:14988604; PMID:15189696; PMID:15190048; PMID:15213374; PMID:15256801; PMID:15493460; PMID:15753151; PMID:15932790; PMID:16115338; PMID:16336861; PMID:16384840; PMID:16400056; PMID:16481153; PMID:16875031; PMID:17823432; PMID:18582912; PMID:19838939; PMID:22411374; PMID:22513202; PMID:22607470; PMID:22888664; PMID:23429409; PMID:2388136; PMID:23993952; PMID:25501796; PMID:25916693; PMID:28211759; PMID:28506847; PMID:28629117; PMID:30361021; PMID:31136626; PMID:31583056; PMID:31957471; PMID:32065446; PMID:32197490; PMID:32488024; PMID:33352218; PMID:33549947; PMID:6618108; PMID:6875389; PMID:6959572; PMID:8514270; PMID:9537614; PMID:9808643; Reaxys:93072; Wikipedia:Gamma-Tocopherol
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Abcc1
ATP binding cassette subfamily C member 1
decreases activity multiple interactions
ISO
Tocopherols results in decreased activity of ABCC1 protein Tocopherols inhibits the reaction [ABCC1 protein affects the export of Etoposide]
CTD
PMID:15617835
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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Alb
albumin
multiple interactions
EXP
gamma-Tocopherol inhibits the reaction [ALB protein results in increased expression of MUC5AC mRNA]
CTD
PMID:19389874
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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App
amyloid beta precursor protein
decreases abundance multiple interactions
EXP
APP protein modified form results in decreased abundance of Tocopherols resveratrol inhibits the reaction [APP protein modified form results in decreased abundance of Tocopherols]
CTD
PMID:25654502
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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Ar
androgen receptor
decreases expression decreases activity
ISO
[Tocopherols results in decreased expression of AR protein] which results in decreased expression of KLK3 protein; Tocopherols results in decreased expression of AR mRNA; Tocopherols results in decreased expression of AR protein Tocopherols results in decreased activity of AR protein
CTD
PMID:12032296 PMID:16302272
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Arf3
ADP-ribosylation factor 3
increases expression
ISO
Tocopherols results in increased expression of ARF3 mRNA
CTD
PMID:17654050
NCBI chr 7:129,886,082...129,912,022
Ensembl chr 7:129,886,082...129,912,002
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Aspm
assembly factor for spindle microtubules
increases expression
ISO
Tocopherols results in increased expression of ASPM mRNA
CTD
PMID:17056531
NCBI chr13:51,074,849...51,123,755
Ensembl chr13:51,074,849...51,123,755
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Atp1a2
ATPase Na+/K+ transporting subunit alpha 2
increases expression
ISO
Tocopherols results in increased expression of ATP1A2 mRNA
CTD
PMID:17654050
NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544
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Atp1b2
ATPase Na+/K+ transporting subunit beta 2
increases expression
ISO
Tocopherols results in increased expression of ATP1B2 mRNA
CTD
PMID:17654050
NCBI chr10:54,318,698...54,324,933
Ensembl chr10:54,318,701...54,324,933
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Aurka
aurora kinase A
increases expression
ISO
Tocopherols results in increased expression of AURKA mRNA
CTD
PMID:17056531
NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
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Bax
BCL2 associated X, apoptosis regulator
increases response to substance increases expression multiple interactions
ISO
BAX protein results in increased susceptibility to Tocopherols gamma-Tocopherol results in increased expression of BAX mRNA [Fluorouracil co-treated with gamma-Tocopherol] results in increased expression of BAX mRNA
CTD
PMID:16001965 PMID:31587439
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
increases expression decreases response to substance decreases expression multiple interactions
ISO
Tocopherols results in increased expression of BCL2 mRNA; Tocopherols results in increased expression of BCL2 protein BCL2 protein results in decreased susceptibility to Tocopherols gamma-Tocopherol results in decreased expression of BCL2 mRNA [Fluorouracil co-treated with gamma-Tocopherol] results in decreased expression of BCL2 mRNA
CTD
PMID:8970189 PMID:16001965 PMID:31587439
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l1
Bcl2-like 1
decreases response to substance
ISO
BCL2L1 protein results in decreased susceptibility to Tocopherols
CTD
PMID:16001965
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Birc5
baculoviral IAP repeat-containing 5
increases expression
ISO
Tocopherols results in increased expression of BIRC5 mRNA
CTD
PMID:17056531
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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Camk2g
calcium/calmodulin-dependent protein kinase II gamma
increases expression
ISO
Tocopherols results in increased expression of CAMK2G mRNA
CTD
PMID:17654050
NCBI chr15:3,504,017...3,563,050
Ensembl chr15:3,504,085...3,563,050
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Casp3
caspase 3
increases activity multiple interactions
ISO EXP
gamma-Tocopherol results in increased activity of CASP3 protein thermozymocidin inhibits the reaction [gamma-Tocopherol results in increased activity of CASP3 protein] [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of CASP3 protein]
CTD
PMID:15596715 PMID:22389237
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9
caspase 9
increases activity
ISO
gamma-Tocopherol results in increased activity of CASP9 protein
CTD
PMID:15596715
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
increases expression
ISO
gamma-Tocopherol results in increased expression of CAT protein
CTD
PMID:19115203
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccnb2
cyclin B2
increases expression
ISO
Tocopherols results in increased expression of CCNB2 mRNA
CTD
PMID:17056531
NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
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Ccnd1
cyclin D1
decreases expression multiple interactions
ISO
gamma-Tocopherol results in decreased expression of CCND1 mRNA; gamma-Tocopherol results in decreased expression of CCND1 protein; Tocopherols results in decreased expression of CCND1 protein [Fluorouracil co-treated with gamma-Tocopherol] results in decreased expression of CCND1 mRNA
CTD
PMID:12368234 PMID:12504091 PMID:31587439
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Ccnd3
cyclin D3
decreases expression
ISO
Tocopherols results in decreased expression of CCND3 protein
CTD
PMID:12504091
NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
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Ccne1
cyclin E1
decreases expression multiple interactions
ISO
gamma-Tocopherol results in decreased expression of CCNE1 mRNA; gamma-Tocopherol results in decreased expression of CCNE1 protein; Tocopherols results in decreased expression of CCNE1 mRNA; Tocopherols results in decreased expression of CCNE1 protein [Fluorouracil co-treated with gamma-Tocopherol] results in decreased expression of CCNE1 mRNA
CTD
PMID:12368234 PMID:12504091 PMID:31587439
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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Cdc6
cell division cycle 6
increases expression
ISO
Tocopherols results in increased expression of CDC6 mRNA
CTD
PMID:17056531
NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011
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Cdk1
cyclin-dependent kinase 1
increases expression
ISO
Tocopherols results in increased expression of CDK1 mRNA
CTD
PMID:17056531
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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Cdk2
cyclin dependent kinase 2
decreases expression
ISO
Tocopherols results in decreased expression of CDK2 protein
CTD
PMID:12504091
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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Cdk4
cyclin-dependent kinase 4
multiple interactions
ISO
Tocopherols results in decreased expression of and results in decreased activity of CDK4 protein
CTD
PMID:12504091
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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Cdk5r1
cyclin-dependent kinase 5 regulatory subunit 1
increases expression
ISO
Tocopherols results in increased expression of CDK5R1 mRNA
CTD
PMID:17654050
NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
decreases expression
ISO
gamma-Tocopherol results in decreased expression of CDKN1A protein
CTD
PMID:12368234
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
decreases expression
ISO
gamma-Tocopherol results in decreased expression of CDKN1B protein
CTD
PMID:12368234
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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Cdkn2a
cyclin-dependent kinase inhibitor 2A
decreases expression
ISO
gamma-Tocopherol results in decreased expression of CDKN2A protein
CTD
PMID:12368234
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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Clec4e
C-type lectin domain family 4, member E
increases expression
ISO
Tocopherols results in increased expression of CLEC4E mRNA
CTD
PMID:17056531
NCBI chr 4:156,606,927...156,612,911
Ensembl chr 4:156,607,614...156,612,767
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Cplx1
complexin 1
increases expression
ISO
Tocopherols results in increased expression of CPLX1 mRNA
CTD
PMID:17654050
NCBI chr14:1,184,677...1,216,392
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Cplx2
complexin 2
increases expression
ISO
Tocopherols results in increased expression of CPLX2 mRNA
CTD
PMID:17654050
NCBI chr17:10,219,577...10,292,835
Ensembl chr17:10,222,347...10,293,855
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Crabp2
cellular retinoic acid binding protein 2
multiple interactions
ISO
[Tretinoin co-treated with gamma-Tocopherol] results in increased expression of CRABP2 mRNA
CTD
PMID:15225641
NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379
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Crp
C-reactive protein
multiple interactions
ISO
[alpha-Tocopherol co-treated with gamma-Tocopherol] results in decreased expression of CRP protein
CTD
PMID:18191645
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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Csf1r
colony stimulating factor 1 receptor
increases expression
ISO
Tocopherols results in increased expression of CSF1R mRNA
CTD
PMID:17056531
NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
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Csrp2
cysteine and glycine-rich protein 2
increases expression
ISO
Tocopherols results in increased expression of CSRP2 mRNA
CTD
PMID:17056531
NCBI chr 7:46,349,109...46,367,743
Ensembl chr 7:46,348,686...46,367,745
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions
EXP
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of CYP1A1 mRNA]
CTD
PMID:22389237
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Dnajc5
DnaJ heat shock protein family (Hsp40) member C5
increases expression
ISO
Tocopherols results in increased expression of DNAJC5 mRNA
CTD
PMID:17654050
NCBI chr 3:168,621,905...168,656,570
Ensembl chr 3:168,621,969...168,655,935
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E2f1
E2F transcription factor 1
increases expression
ISO
Tocopherols results in increased expression of E2F1 protein
CTD
PMID:15883045
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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Egr1
early growth response 1
decreases activity
ISO
Tocopherols results in decreased activity of EGR1 protein
CTD
PMID:15878867
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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Esr1
estrogen receptor 1
multiple interactions
EXP
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR1 protein]
CTD
PMID:22389237
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Esr2
estrogen receptor 2
multiple interactions
EXP
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR2 mRNA]
CTD
PMID:22389237
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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Fcer1a
Fc epsilon receptor Ia
increases expression
ISO
Tocopherols results in increased expression of FCER1A mRNA
CTD
PMID:17056531
NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351
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Fes
FES proto-oncogene, tyrosine kinase
increases expression
ISO
Tocopherols results in increased expression of FES mRNA
CTD
PMID:17056531
NCBI chr 1:134,337,698...134,346,934
Ensembl chr 1:134,337,698...134,346,934
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Fgf1
fibroblast growth factor 1
decreases expression
ISO
Tocopherols results in decreased expression of FGF1 mRNA
CTD
PMID:15878867
NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
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Fgf2
fibroblast growth factor 2
decreases expression
ISO
Tocopherols results in decreased expression of FGF2 mRNA
CTD
PMID:15878867
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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Fgfr1
Fibroblast growth factor receptor 1
decreases expression
ISO
Tocopherols results in decreased expression of FGFR1 mRNA
CTD
PMID:15144885
NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350
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Fkbp9
FKBP prolyl isomerase 9
increases expression
ISO
Tocopherols results in increased expression of FKBP9 mRNA
CTD
PMID:17056531
NCBI chr 4:86,106,256...86,156,723
Ensembl chr 4:86,106,282...86,156,721
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
Tocopherols results in increased expression of FOS mRNA; Tocopherols results in increased expression of FOS protein
CTD
PMID:8970189
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Gclm
glutamate cysteine ligase, modifier subunit
multiple interactions
EXP
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GCLM mRNA]
CTD
PMID:22389237
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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Gria2
glutamate ionotropic receptor AMPA type subunit 2
increases expression
ISO
Tocopherols results in increased expression of GRIA2 mRNA
CTD
PMID:17654050
NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510
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Grin1
glutamate ionotropic receptor NMDA type subunit 1
increases expression
ISO
Tocopherols results in increased expression of GRIN1 mRNA
CTD
PMID:17654050
NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
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Gstm1
glutathione S-transferase mu 1
increases expression multiple interactions
ISO EXP
gamma-Tocopherol results in increased expression of GSTM1 mRNA; gamma-Tocopherol results in increased expression of GSTM1 protein [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GSTM1 mRNA]
CTD
PMID:19115203 PMID:22389237
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
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Gsto1
glutathione S-transferase omega 1
decreases activity
ISO
Tocopherols results in decreased activity of GSTO1 protein
CTD
PMID:16781109
NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468
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Haspin
histone H3 associated protein kinase
increases expression
ISO
Tocopherols results in increased expression of HASPIN mRNA
CTD
PMID:17056531
NCBI chr10:57,747,731...57,750,518
Ensembl chr10:57,747,573...57,750,512
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Hmox1
heme oxygenase 1
increases expression multiple interactions
ISO EXP
gamma-Tocopherol results in increased expression of HMOX1 protein [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of HMOX1 protein]
CTD
PMID:19115203 PMID:22389237
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
Tocopherols results in increased expression of JUN mRNA; Tocopherols results in increased expression of JUN protein
CTD
PMID:8970189
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Kif20a
kinesin family member 20A
increases expression
ISO
Tocopherols results in increased expression of KIF20A mRNA
CTD
PMID:17056531
NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780
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Kif4a
kinesin family member 4A
increases expression
ISO
Tocopherols results in increased expression of KIF4 mRNA
CTD
PMID:17056531
NCBI chr X:65,721,746...65,824,277
Ensembl chr X:65,721,779...65,824,139
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Klk1c10
kallikrein 1-related peptidase C10
decreases expression multiple interactions
ISO
[Tocopherols results in decreased expression of AR protein] which results in decreased expression of KLK3 protein; Tocopherols results in decreased expression of KLK3 mRNA; Tocopherols results in decreased expression of KLK3 protein Tocopherols inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA]; Tocopherols inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 protein]
CTD
PMID:12032296 PMID:16302272
NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052
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Mcl1
MCL1 apoptosis regulator, BCL2 family member
decreases response to substance
ISO
MCL1 protein results in decreased susceptibility to Tocopherols
CTD
PMID:16001965
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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Muc5ac
mucin 5AC, oligomeric mucus/gel-forming
multiple interactions
EXP
gamma-Tocopherol inhibits the reaction [ALB protein results in increased expression of MUC5AC mRNA]
CTD
PMID:19389874
NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
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Myc
MYC proto-oncogene, bHLH transcription factor
decreases expression decreases activity
ISO
Tocopherols results in decreased expression of MYC mRNA Tocopherols results in decreased activity of MYC protein
CTD
PMID:8970189
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Napb
NSF attachment protein beta
increases expression
ISO
Tocopherols results in increased expression of NAPB mRNA
CTD
PMID:17654050
NCBI chr 3:136,132,248...136,179,280
Ensembl chr 3:136,133,428...136,179,345
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Nfe2l2
NFE2 like bZIP transcription factor 2
increases expression multiple interactions
ISO EXP
gamma-Tocopherol results in increased expression of NFE2L2 mRNA; gamma-Tocopherol results in increased expression of NFE2L2 protein [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NFE2L2 protein]
CTD
PMID:19115203 PMID:22389237
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions
EXP
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NQO1 mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NQO1 protein]
CTD
PMID:22389237
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nsf
N-ethylmaleimide sensitive factor, vesicle fusing ATPase
increases expression
ISO
Tocopherols results in increased expression of NSF mRNA
CTD
PMID:17654050
NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386
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Pcna
proliferating cell nuclear antigen
multiple interactions decreases expression
EXP
[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PCNA protein] Tocopherols results in decreased expression of PCNA
CTD
PMID:17927505 PMID:22389237
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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Pparg
peroxisome proliferator-activated receptor gamma
increases expression multiple interactions
ISO EXP
gamma-Tocopherol results in increased expression of PPARG mRNA; gamma-Tocopherol results in increased expression of PPARG protein [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG mRNA]; [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PPARG protein]
CTD
PMID:14521714 PMID:22389237
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Ppp3ca
protein phosphatase 3 catalytic subunit alpha
increases expression
ISO
Tocopherols results in increased expression of PPP3CA mRNA
CTD
PMID:17654050
NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
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Prtn3
proteinase 3
increases expression
ISO
Tocopherols results in increased expression of PRTN3 mRNA
CTD
PMID:17056531
NCBI chr 7:9,822,123...9,831,300
Ensembl chr 7:9,822,122...9,831,944
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Ptgs2
prostaglandin-endoperoxide synthase 2
decreases activity multiple interactions
ISO EXP
gamma-Tocopherol results in decreased activity of PTGS2 protein [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of PTGS2 protein]
CTD
PMID:15225597 PMID:22389237
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Ptpro
protein tyrosine phosphatase, receptor type, O
increases expression
ISO
Tocopherols results in increased expression of PTPRO mRNA
CTD
PMID:17056531
NCBI chr 4:170,164,071...170,374,790
Ensembl chr 4:170,164,431...170,374,771
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Rab11b
RAB11B, member RAS oncogene family
increases expression
ISO
Tocopherols results in increased expression of RAB11B mRNA
CTD
PMID:17654050
NCBI chr 7:14,521,448...14,534,589
Ensembl chr 7:14,521,368...14,534,593
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Rab3a
RAB3A, member RAS oncogene family
increases expression
ISO
Tocopherols results in increased expression of RAB3A mRNA
CTD
PMID:17654050
NCBI chr16:18,684,185...18,688,297
Ensembl chr16:18,684,188...18,688,336
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Rab6b
RAB6B, member RAS oncogene family
increases expression
ISO
Tocopherols results in increased expression of RAB6B mRNA
CTD
PMID:17654050
NCBI chr 8:103,695,328...103,764,023
Ensembl chr 8:103,695,631...103,805,732
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Rb1
RB transcriptional corepressor 1
decreases phosphorylation
ISO
Tocopherols results in decreased phosphorylation of RB1 protein
CTD
PMID:12504091
NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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Rrm1
ribonucleotide reductase catalytic subunit M1
increases expression
ISO
Tocopherols results in increased expression of RRM1 mRNA
CTD
PMID:17056531
NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261
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Rrm2
ribonucleotide reductase regulatory subunit M2
increases expression
ISO
Tocopherols results in increased expression of RRM2 mRNA
CTD
PMID:17056531
NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
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Snca
synuclein alpha
increases expression
ISO
Tocopherols results in increased expression of SNCA mRNA
CTD
PMID:17654050
NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
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Sncb
synuclein, beta
increases expression
ISO
Tocopherols results in increased expression of SNCB mRNA
CTD
PMID:17654050
NCBI chr17:9,846,802...9,855,013
Ensembl chr17:9,846,802...9,855,012
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Sod1
superoxide dismutase 1
increases expression
ISO
gamma-Tocopherol results in increased expression of SOD1 protein
CTD
PMID:19115203
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Stx1a
syntaxin 1A
increases expression
ISO
Tocopherols results in increased expression of STX1A mRNA
CTD
PMID:17654050
NCBI chr12:21,641,971...21,670,022
Ensembl chr12:21,641,969...21,669,930
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Stxbp1
syntaxin binding protein 1
increases expression
ISO
Tocopherols results in increased expression of STXBP1 mRNA
CTD
PMID:17654050
NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369
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Sv2a
synaptic vesicle glycoprotein 2a
increases expression
ISO
Tocopherols results in increased expression of SV2A mRNA
CTD
PMID:17654050
NCBI chr 2:183,741,489...183,757,290
Ensembl chr 2:183,741,547...183,756,927
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Syn1
synapsin I
increases expression
ISO
Tocopherols results in increased expression of SYN1 mRNA
CTD
PMID:17654050
NCBI chr X:1,172,208...1,227,400
Ensembl chr X:1,172,208...1,227,396
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Syn2
synapsin II
increases expression
ISO
Tocopherols results in increased expression of SYN2 mRNA
CTD
PMID:17654050
NCBI chr 4:148,178,846...148,347,010
Ensembl chr 4:148,186,270...148,344,192
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Syngr1
synaptogyrin 1
increases expression
ISO
Tocopherols results in increased expression of SYNGR1 mRNA
CTD
PMID:17654050
NCBI chr 7:111,635,911...111,659,341
Ensembl chr 7:111,635,918...111,659,341
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Syp
synaptophysin
increases expression
ISO
Tocopherols results in increased expression of SYP mRNA
CTD
PMID:17654050
NCBI chr X:14,849,444...14,864,553
Ensembl chr X:14,849,444...14,864,745
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Syt11
synaptotagmin 11
increases expression
ISO
Tocopherols results in increased expression of SYT11 mRNA
CTD
PMID:17654050
NCBI chr 2:174,206,032...174,232,540
Ensembl chr 2:174,206,191...174,231,964
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Syt13
synaptotagmin 13
increases expression
ISO
Tocopherols results in increased expression of SYT13 mRNA
CTD
PMID:17654050
NCBI chr 3:78,877,114...78,917,527
Ensembl chr 3:78,877,114...78,917,392
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Tnf
tumor necrosis factor
multiple interactions
ISO EXP
[alpha-Tocopherol co-treated with gamma-Tocopherol] results in decreased expression of TNF protein Tocopherols inhibits the reaction [TNF protein results in decreased export of Potassium]
CTD
PMID:17337591 PMID:18191645
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfaip2
TNF alpha induced protein 2
increases expression
ISO
Tocopherols results in increased expression of TNFAIP2 mRNA
CTD
PMID:17056531
NCBI chr 6:130,476,832...130,489,914
Ensembl chr 6:130,476,889...130,489,914
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Tp53
tumor protein p53
increases activity
ISO
Tocopherols results in increased activity of TP53 protein
CTD
PMID:15883045
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Ttc3
tetratricopeptide repeat domain 3
increases expression
ISO
Tocopherols results in increased expression of TTC3 mRNA
CTD
PMID:17654050
NCBI chr11:33,689,119...33,788,976
Ensembl chr11:33,688,952...33,788,975
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Ugt1a1
UDP glucuronosyltransferase family 1 member A1
increases expression multiple interactions
ISO EXP
gamma-Tocopherol results in increased expression of UGT1A1 mRNA [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of UGT1A1 mRNA]
CTD
PMID:19115203 PMID:22389237
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Vamp1
vesicle-associated membrane protein 1
increases expression
ISO
Tocopherols results in increased expression of VAMP1 mRNA
CTD
PMID:17654050
NCBI chr 4:158,012,634...158,019,350
Ensembl chr 4:158,012,663...158,019,349
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Vamp2
vesicle-associated membrane protein 2
increases expression
ISO
Tocopherols results in increased expression of VAMP2 mRNA
CTD
PMID:17654050
NCBI chr10:53,793,581...53,797,815
Ensembl chr10:53,793,923...53,797,809
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Vdr
vitamin D receptor
increases expression
ISO
Tocopherols results in increased expression of VDR mRNA
CTD
PMID:12032296
NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
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