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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:aureusidin
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Accession:CHEBI:18149 term browser browse the term
Definition:A hydroxyaurone that is aurone substituted by hydroxy groups at positions 4, 6, 3' and 4' respectively.
Synonyms:exact_synonym: (2Z)-2-[(3,4-dihydroxyphenyl)methylidene]-4,6-dihydroxy-1-benzofuran-3(2H)-one
 related_synonym: Formula=C15H10O6;   InChI=1S/C15H10O6/c16-8-5-11(19)14-12(6-8)21-13(15(14)20)4-7-1-2-9(17)10(18)3-7/h1-6,16-19H/b13-4-;   InChIKey=WBEFUVAYFSOUEA-PQMHYQBVSA-N;   SMILES=Oc1cc(O)c2C(=O)\\C(Oc2c1)=C\\c1ccc(O)c(O)c1
 alt_id: CHEBI:13867;   CHEBI:2926
 xref: CAS:38216-54-5;   KEGG:C08576;   KNApSAcK:C00008027
 xref_mesh: MESH:C416232
 xref: PMID:22924954;   Reaxys:35491
 cyclic_relationship: is_conjugate_acid_of CHEBI:58393


show annotations for term's descendants           Sort by:
aureusidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation EXP aureusidin results in increased phosphorylation of AKT1 protein CTD PMID:31790703 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO aureusidin inhibits the reaction [Oxidopamine results in increased expression of BAX mRNA]; aureusidin inhibits the reaction [Oxidopamine results in increased expression of BAX protein] CTD PMID:38056806 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO aureusidin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 mRNA]; aureusidin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein] CTD PMID:38056806 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO aureusidin inhibits the reaction [Oxidopamine results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:38056806 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions ISO aureusidin inhibits the reaction [Oxidopamine results in decreased activity of CAT protein] CTD PMID:38056806 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO aureusidin inhibits the reaction [Oxidopamine results in increased expression of and affects the localization of CYCS protein] CTD PMID:38056806 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 EXP
ISO		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [aureusidin results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [aureusidin results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [aureusidin results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [aureusidin results in increased expression of HMOX1 protein]
aureusidin results in increased expression of HMOX1 mRNA; aureusidin results in increased expression of HMOX1 protein		 CTD PMID:31790703 PMID:38056806 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO aureusidin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:31790703 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression
increases expression		 EXP
ISO		 aureusidin results in decreased expression of KEAP1 mRNA; aureusidin results in decreased expression of KEAP1 protein
aureusidin results in increased expression of KEAP1 mRNA		 CTD PMID:31790703 PMID:38056806 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 EXP aureusidin results in increased phosphorylation of MAPK1 protein
Acetylcysteine inhibits the reaction [aureusidin results in increased phosphorylation of MAPK1 protein]		 CTD PMID:31790703 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 EXP aureusidin results in increased phosphorylation of MAPK3 protein
Acetylcysteine inhibits the reaction [aureusidin results in increased phosphorylation of MAPK3 protein]		 CTD PMID:31790703 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation		 EXP Acetylcysteine inhibits the reaction [aureusidin results in increased phosphorylation of MAPK8 protein] CTD PMID:31790703 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression
affects localization		 EXP
ISO		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [aureusidin affects the localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [aureusidin affects the localization of NFE2L2 protein]; aureusidin results in increased expression of and affects the localization of NFE2L2 protein; pyrazolanthrone inhibits the reaction [aureusidin affects the localization of NFE2L2 protein]; SB 203580 inhibits the reaction [aureusidin affects the localization of NFE2L2 protein]
aureusidin results in increased expression of NFE2L2 mRNA		 CTD PMID:31790703 PMID:38056806 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO aureusidin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:31790703 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO aureusidin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; aureusidin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:31790703 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP
ISO		 aureusidin results in increased expression of NQO1 mRNA CTD PMID:31790703 PMID:38056806 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO aureusidin inhibits the reaction [Oxidopamine affects the cleavage of PARP1 protein] CTD PMID:38056806 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO aureusidin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; aureusidin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:31790703 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO aureusidin inhibits the reaction [Lipopolysaccharides results in increased expression of and affects the localization of RELA protein] CTD PMID:31790703 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO aureusidin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; aureusidin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:31790703 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        biochemical role 19556
          metabolite 19544
            eukaryotic metabolite 19368
              plant metabolite 17985
                aureusidin 14
                  4,6,3',4'-tetramethoxyaurone 0
                  aureusidin 6-O-beta-glucoside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic heterocyclic compound 18874
                                  oxacycle 17906
                                    benzofurans 3287
                                      1-benzofurans 1427
                                        aurones 14
                                          aurone 14
                                            aureusidin 14
                                              4,6,3',4'-tetramethoxyaurone 0
                                              aureusidin 6-O-beta-glucoside 0
paths to the root