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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:aureusidin
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Accession:CHEBI:18149 term browser browse the term
Definition:A hydroxyaurone that is aurone substituted by hydroxy groups at positions 4, 6, 3' and 4' respectively.
Synonyms:related_synonym: (2Z)-2-[(3,4-dihydroxyphenyl)methylidene]-4,6-dihydroxy-1-benzofuran-3(2H)-one
 alt_id: CHEBI:13867;   CHEBI:2926
 xref: CAS:38216-54-5;   KNApSAcK:C00008027
 xref_mesh: MESH:C416232
 xref: Reaxys:35491;   kegg.compound:C08576;   pubmed:22924954
 chemrof_formula: C15H10O6
 chemrof_inchi: InChI=1S/C15H10O6/c16-8-5-11(19)14-12(6-8)21-13(15(14)20)4-7-1-2-9(17)10(18)3-7/h1-6,16-19H/b13-4-
 chemrof_smiles: O=C1/C(=C/c2ccc(O)c(O)c2)Oc2cc(O)cc(O)c21
 chemrof_inchikey: WBEFUVAYFSOUEA-PQMHYQBVSA-N
 cyclic_relationship: has_functional_parent CHEBI:47964;   is_conjugate_acid_of CHEBI:58393


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aureusidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation EXP aureusidin results in increased phosphorylation of AKT1 protein CTD PMID:31790703 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO aureusidin inhibits the reaction [Oxidopamine results in increased expression of BAX mRNA]; aureusidin inhibits the reaction [Oxidopamine results in increased expression of BAX protein] CTD PMID:38056806 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO aureusidin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 mRNA]; aureusidin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein] CTD PMID:38056806 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO aureusidin inhibits the reaction [Oxidopamine results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:38056806 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cat catalase multiple interactions ISO aureusidin inhibits the reaction [Oxidopamine results in decreased activity of CAT protein] CTD PMID:38056806 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO aureusidin inhibits the reaction [Oxidopamine results in increased expression of and affects the localization of CYCS protein] CTD PMID:38056806 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression 		EXP
ISO 		2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [aureusidin results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [aureusidin results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [aureusidin results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [aureusidin results in increased expression of HMOX1 protein]
aureusidin results in increased expression of HMOX1 mRNA; aureusidin results in increased expression of HMOX1 protein 		CTD PMID:31790703 PMID:38056806 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO aureusidin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:31790703 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression
increases expression 		EXP
ISO 		aureusidin results in decreased expression of KEAP1 mRNA; aureusidin results in decreased expression of KEAP1 protein
aureusidin results in increased expression of KEAP1 mRNA 		CTD PMID:31790703 PMID:38056806 NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions 		EXP aureusidin results in increased phosphorylation of MAPK1 protein
Acetylcysteine inhibits the reaction [aureusidin results in increased phosphorylation of MAPK1 protein] 		CTD PMID:31790703 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions 		EXP aureusidin results in increased phosphorylation of MAPK3 protein
Acetylcysteine inhibits the reaction [aureusidin results in increased phosphorylation of MAPK3 protein] 		CTD PMID:31790703 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation 		EXP Acetylcysteine inhibits the reaction [aureusidin results in increased phosphorylation of MAPK8 protein] CTD PMID:31790703 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression
affects localization 		EXP
ISO 		2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [aureusidin affects the localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [aureusidin affects the localization of NFE2L2 protein]; aureusidin results in increased expression of and affects the localization of NFE2L2 protein; pyrazolanthrone inhibits the reaction [aureusidin affects the localization of NFE2L2 protein]; SB 203580 inhibits the reaction [aureusidin affects the localization of NFE2L2 protein]
aureusidin results in increased expression of NFE2L2 mRNA 		CTD PMID:31790703 PMID:38056806 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO aureusidin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:31790703 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO aureusidin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; aureusidin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:31790703 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP
ISO 		aureusidin results in increased expression of NQO1 mRNA CTD PMID:31790703 PMID:38056806 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO aureusidin inhibits the reaction [Oxidopamine affects the cleavage of PARP1 protein] CTD PMID:38056806 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO aureusidin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; aureusidin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:31790703 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO aureusidin inhibits the reaction [Lipopolysaccharides results in increased expression of and affects the localization of RELA protein] CTD PMID:31790703 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO aureusidin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; aureusidin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:31790703 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        biochemical role 19888
          metabolite 19624
            eukaryotic metabolite 19368
              plant metabolite 16205
                aureusidin 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                organic heterocyclic compound 19381
                                  oxacycle 18273
                                    benzofurans 3322
                                      1-benzofurans 1437
                                        aurones 20
                                          hydroxyaurone 20
                                            aureusidin 20
paths to the root