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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1,4-dihydroxy-2-naphthoic acid
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Accession:CHEBI:18094 term browser browse the term
Definition:A naphthoic acid that is 2-naphthoic acid substituted by hydroxy groups at positions 1 and 4.
Synonyms:related_synonym: 1,4-Dihydroxy-2-naphthalenecarboxylic acid;   1,4-dihydroxynaphthalene-2-carboxylic acid;   Formula=C11H8O4;   InChI=1S/C11H8O4/c12-9-5-8(11(14)15)10(13)7-4-2-1-3-6(7)9/h1-5,12-13H,(H,14,15);   InChIKey=VOJUXHHACRXLTD-UHFFFAOYSA-N;   SMILES=OC(=O)c1cc(O)c2ccccc2c1O
 alt_id: CHEBI:18933;   CHEBI:539
 xref: Beilstein:2111226;   CAS:31519-22-9;   ECMDB:ECMDB04054;   KEGG:C03657;   KNApSAcK:C00000736
 xref_mesh: MESH:C024023
 xref: PMID:1091286;   PMID:23801651;   Reaxys:2111226
 cyclic_relationship: is_conjugate_acid_of CHEBI:11173


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1,4-dihydroxy-2-naphthoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO 1,4-dihydroxy-2-naphthoic acid binds to and results in increased activity of AHR protein; [1,4-dihydroxy-2-naphthoic acid binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; [1,4-dihydroxy-2-naphthoic acid binds to and results in increased activity of AHR protein] which results in increased expression of CYP1B1 mRNA CTD PMID:27837168 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [1,4-dihydroxy-2-naphthoic acid binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA CTD PMID:27837168 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO [1,4-dihydroxy-2-naphthoic acid binds to and results in increased activity of AHR protein] which results in increased expression of CYP1B1 mRNA CTD PMID:27837168 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Gpr35 G protein-coupled receptor 35 multiple interactions ISO 1,4-dihydroxy-2-naphthoic acid binds to and results in increased activity of GPR35 protein CTD PMID:20826425 NCBI chr 9:93,527,165...93,539,573
Ensembl chr 9:93,527,127...93,539,299 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19917
    role 19887
      biological role 19885
        biochemical role 19569
          metabolite 19577
            xenobiotic metabolite 16161
              2-naphthoic acid 14
                1,4-dihydroxy-2-naphthoic acid 4
                  1,4-dihydroxy-2-naphthoyl-CoA 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19917
    subatomic particle 19915
      composite particle 19915
        hadron 19915
          baryon 19915
            nucleon 19915
              atomic nucleus 19915
                atom 19915
                  main group element atom 19855
                    p-block element atom 19855
                      carbon group element atom 19774
                        carbon atom 19790
                          organic molecular entity 19790
                            organic molecule 19743
                              organic cyclic compound 19533
                                carbocyclic compound 18614
                                  carbopolycyclic compound 17190
                                    carbobicyclic compound 5895
                                      naphthalenes 3860
                                        hydroxynaphthalene 282
                                          naphthalenediols 14
                                            1,4-dihydroxy-2-naphthoic acid 4
                                              1,4-dihydroxy-2-naphthoyl-CoA 0
paths to the root