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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:7-Hydroxymitragynine
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Accession:CHEBI:180536 term browser browse the term
Synonyms:exact_synonym: methyl (E)-2-[(2S,3S,7aS,12bS)-3-ethyl-7a-hydroxy-8-methoxy-2,3,4,6,7,12b-hexahydro-1H-indolo[2,3-a]quinolizin-2-yl]-3-methoxyprop-2-enoate
 related_synonym: Formula=C23H30N2O5;   InChI=1S/C23H30N2O5/c1-5-14-12-25-10-9-23(27)20-17(7-6-8-19(20)29-3)24-21(23)18(25)11-15(14)16(13-28-2)22(26)30-4/h6-8,13-15,18,27H,5,9-12H2,1-4H3/b16-13+/t14-,15+,18+,23+/m1/s1;   InChIKey=RYENLSMHLCNXJT-CYXFISRXSA-N;   SMILES=O[C@]12C(=NC3=C1C(OC)=CC=C3)[C@]4(N(C[C@H]([C@H](C4)/C(/C(OC)=O)=C\\OC)CC)CC2)[H]
 xref: CAS:174418-82-7;   Chemspider:23152144
 xref_mesh: MESH:C482678


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7-Hydroxymitragynine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oprd1 opioid receptor, delta 1 multiple interactions ISO 7-hydroxymitragynine binds to and affects the activity of OPRD1 protein
7-hydroxymitragynine affects the reaction [Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein]		 CTD PMID:27192616 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprk1 opioid receptor, kappa 1 multiple interactions
affects binding		 ISO 7-hydroxymitragynine inhibits the reaction [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein]
7-hydroxymitragynine binds to OPRK1 protein		 CTD PMID:27192616 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprm1 opioid receptor, mu 1 increases activity
multiple interactions
affects binding		 ISO 7-hydroxymitragynine results in increased activity of OPRM1 protein
7-hydroxymitragynine affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]; 7-hydroxymitragynine binds to and results in increased activity of OPRM1 protein
7-hydroxymitragynine binds to OPRM1 protein		 CTD PMID:27192616 PMID:32734307 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19867
    role 19837
      biological role 19835
        biochemical role 19552
          metabolite 19539
            alkaloid 8020
              7-Hydroxymitragynine 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19867
    subatomic particle 19865
      composite particle 19865
        hadron 19865
          baryon 19865
            nucleon 19865
              atomic nucleus 19865
                atom 19865
                  main group element atom 19803
                    main group molecular entity 19803
                      p-block molecular entity 19803
                        carbon group molecular entity 19744
                          organic molecular entity 19740
                            heteroorganic entity 19512
                              organonitrogen compound 18832
                                alkaloid 8020
                                  7-Hydroxymitragynine 3
paths to the root