Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:L-glutamine
go back to main search page
Accession:CHEBI:18050 term browser browse the term
Definition:An optically active form of glutamine having L-configuration.
Synonyms:related_synonym: (2S)-2,5-diamino-5-oxopentanoic acid;   (2S)-2-amino-4-carbamoylbutanoic acid;   (S)-2,5-diamino-5-oxopentanoic acid;   Formula=C5H10N2O3;   GLUTAMINE;   Glutamic acid 5-amide;   Glutamic acid amide;   InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1;   InChIKey=ZDXPYRJPNDTMRX-VKHMYHEASA-N;   L-2-Aminoglutaramic acid;   L-Glutamin;   L-Glutaminsaeure-5-amid;   L-glutamic acid gamma-amide;   Levoglutamide;   Q;   SMILES=N[C@@H](CCC(N)=O)C(O)=O
 alt_id: CHEBI:13110;   CHEBI:21308;   CHEBI:42812;   CHEBI:42814;   CHEBI:42899;   CHEBI:42943;   CHEBI:6227
 xref: Beilstein:1723797;   CAS:56-85-9;   DrugBank:DB00130;   Drug_Central:1311;   ECMDB:ECMDB00641;   Gmelin:3509;   HMDB:HMDB0000641;   KEGG:C00064;   KEGG:D00015;   KNApSAcK:C00001359;   LINCS:LSM-4741
 xref_mesh: MESH:D005973
 xref: MetaCyc:GLN;   PDBeChem:GLN;   PMID:11139387;   PMID:15204730;   PMID:22055478;   PMID:22206385;   PMID:22451274;   PMID:22453904;   PMID:22575040;   PMID:22770225;   PMID:29438107;   Reaxys:1723797;   Wikipedia:Glutamine;   YMDB:YMDB00002
 cyclic_relationship: is_conjugate_acid_of CHEBI:32665;   is_conjugate_base_of CHEBI:32666;   is_enantiomer_of CHEBI:17061;   is_tautomer_of CHEBI:58359


show annotations for term's descendants           Sort by:
L-glutamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase multiple interactions EXP Glutamine inhibits the reaction [Fructose results in increased activity of ADA protein] CTD PMID:31233715 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Glutamine deficiency inhibits the reaction [sodium arsenite results in increased expression of CCND1 protein] CTD PMID:33781819 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP Glutamine deficiency results in increased expression of DDIT3 mRNA CTD PMID:23123503 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Fgf21 fibroblast growth factor 21 increases expression EXP Glutamine deficiency results in increased expression of FGF21 mRNA CTD PMID:23123503 NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP Glutamine inhibits the reaction [Fructose results in decreased expression of G6PD protein] CTD PMID:31233715 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Got1l1 glutamic-oxaloacetic transaminase 1-like 1 affects abundance ISO GOT1L1 protein affects the abundance of Glutamine CTD PMID:25287256 NCBI chr16:64,860,308...64,873,656
Ensembl chr16:64,860,704...64,866,162 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression EXP Glutamine deficiency results in increased expression of HSPA5 mRNA CTD PMID:23123503 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Glutamine deficiency inhibits the reaction [sodium arsenite results in increased expression of PCNA protein] CTD PMID:33781819 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression EXP Glutamine deficiency results in increased expression of PPP1R15A mRNA CTD PMID:23123503 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP Glutamine inhibits the reaction [Fructose results in increased activity of XDH protein] CTD PMID:31233715 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
N(5)-ethyl-L-glutamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccn2 cellular communication network factor 2 multiple interactions
decreases expression		 EXP theanine inhibits the reaction [Carbon Tetrachloride results in increased expression of CCN2 protein]
theanine results in decreased expression of CCN2 protein		 CTD PMID:25852135 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccna2 cyclin A2 multiple interactions EXP theanine inhibits the reaction [Carbon Tetrachloride results in increased expression of CCNA2 mRNA] CTD PMID:25852135 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions EXP theanine inhibits the reaction [Carbon Tetrachloride results in increased activity of GGT1 protein] CTD PMID:25852135 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP theanine inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein] CTD PMID:25852135 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Il10 interleukin 10 increases expression
multiple interactions		 EXP theanine results in increased expression of IL10 protein
theanine promotes the reaction [Carbon Tetrachloride results in increased expression of IL10 protein]		 CTD PMID:25852135 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression		 EXP theanine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]
theanine results in decreased expression of IL1B protein		 CTD PMID:25852135 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions		 EXP theanine results in decreased expression of IL6 protein
theanine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]		 CTD PMID:25852135 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions EXP theanine affects the reaction [Carbon Tetrachloride results in increased expression of MMP13 protein] CTD PMID:25852135 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression
multiple interactions		 EXP theanine results in decreased expression of RELA protein
theanine inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein]		 CTD PMID:25852135 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions		 EXP theanine results in decreased expression of TGFB1 protein
theanine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; theanine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]		 CTD PMID:25852135 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    role 19894
      application 19735
        pharmaceutical 19543
          drug 19543
            nutraceutical 13374
              L-glutamine 20
                2-methyl-L-glutamine 0
                Ala-Asn-Gln-Ser 0
                Ala-Gln-Pro 0
                Ala-Leu-Thr-Gln 0
                Ala-Met-Gln-Gln 0
                Arg-Asn-Gln-Arg 0
                Arg-Asp-Gln-Ser 0
                Asn-Gln 0
                Asn-Met-Gln-Pro 0
                Asp-Gln-Arg 0
                Asp-Gln-Ser 0
                Asp-Leu-Asp-Gln 0
                Asp-Leu-Leu-Gln 0
                Asp-Phe-Asp-Gln 0
                Cys-Gln-Gln 0
                Cys-Met-Gln 0
                Gln-Asn 0
                Gln-Cys-Cys 0
                Gln-Gln 0
                Gln-Leu 0
                Gln-Leu-Leu-Pro 0
                Gln-Phe 0
                Gln-Phe-Trp-Tyr 0
                Gln-Phe-Tyr 0
                Gln-Ser 0
                Gln-Trp 0
                Gln-Tyr 0
                Gln-Val 0
                Glu-Asp-Gln-Gln 0
                Glu-Gln 0
                Glu-Glu-Gln 0
                Glu-Phe-Gln-Gln 0
                L-glutamine derivative + 10
                L-glutamine residue + 0
                L-glutaminyl group 0
                Leu-Asp-Gln 0
                Leu-Thr-Gln 0
                Lys-Gln 0
                N(2)-L-glutamino group 0
                N(5)-L-glutamino group 0
                chrysopine + 0
                gamma-Glu-Gln 0
                gamma-glutamyl-beta-cyanoalanine 0
                indigoidine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    main group molecular entity 19838
                      s-block molecular entity 19698
                        hydrogen molecular entity 19679
                          hydrides 19181
                            inorganic hydride 18192
                              pnictogen hydride 18157
                                nitrogen hydride 18070
                                  azane 17873
                                    ammonia 17898
                                      organic amino compound 17898
                                        amino acid 16074
                                          alpha-amino acid 13947
                                            L-alpha-amino acid 12968
                                              glutamine family amino acid 10325
                                                L-glutamine 20
                                                  2-methyl-L-glutamine 0
                                                  Ala-Asn-Gln-Ser 0
                                                  Ala-Gln-Pro 0
                                                  Ala-Leu-Thr-Gln 0
                                                  Ala-Met-Gln-Gln 0
                                                  Arg-Asn-Gln-Arg 0
                                                  Arg-Asp-Gln-Ser 0
                                                  Asn-Gln 0
                                                  Asn-Met-Gln-Pro 0
                                                  Asp-Gln-Arg 0
                                                  Asp-Gln-Ser 0
                                                  Asp-Leu-Asp-Gln 0
                                                  Asp-Leu-Leu-Gln 0
                                                  Asp-Phe-Asp-Gln 0
                                                  Cys-Gln-Gln 0
                                                  Cys-Met-Gln 0
                                                  Gln-Asn 0
                                                  Gln-Cys-Cys 0
                                                  Gln-Gln 0
                                                  Gln-Leu 0
                                                  Gln-Leu-Leu-Pro 0
                                                  Gln-Phe 0
                                                  Gln-Phe-Trp-Tyr 0
                                                  Gln-Phe-Tyr 0
                                                  Gln-Ser 0
                                                  Gln-Trp 0
                                                  Gln-Tyr 0
                                                  Gln-Val 0
                                                  Glu-Asp-Gln-Gln 0
                                                  Glu-Gln 0
                                                  Glu-Glu-Gln 0
                                                  Glu-Phe-Gln-Gln 0
                                                  L-glutamine derivative + 10
                                                  L-glutamine residue + 0
                                                  L-glutaminyl group 0
                                                  Leu-Asp-Gln 0
                                                  Leu-Thr-Gln 0
                                                  Lys-Gln 0
                                                  N(2)-L-glutamino group 0
                                                  N(5)-L-glutamino group 0
                                                  chrysopine + 0
                                                  gamma-Glu-Gln 0
                                                  gamma-glutamyl-beta-cyanoalanine 0
                                                  indigoidine 0
paths to the root