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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:amperozide
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Accession:CHEBI:180480 term browser browse the term
Definition:A member of the class of ureas that is urea in which three of the four hydrogens are replaced by ethyl and 4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl groups. An atypical antipsychotic which was in clinical development for the treatment of schizophrenia and substance-related disorders. It is a potent 5-HT2A antagonist and used in veterinary medicine because of its sedative effect on pigs.
Synonyms:exact_synonym: 4-[4,4-bis(4-fluorophenyl)butyl]-N-ethylpiperazine-1-carboxamide
 related_synonym: 4-(4,4-bis(p-fluorophenyl)butyl)-N-ethyl-1-piperazinecarboxamide;   Formula=C23H29F2N3O;   InChI=1S/C23H29F2N3O/c1-2-26-23(29)28-16-14-27(15-17-28)13-3-4-22(18-5-9-20(24)10-6-18)19-7-11-21(25)12-8-19/h5-12,22H,2-4,13-17H2,1H3,(H,26,29);   InChIKey=NNAIYOXJNVGUOM-UHFFFAOYSA-N;   SMILES=CCNC(=O)N1CCN(CCCC(C2=CC=C(F)C=C2)C2=CC=C(F)C=C2)CC1;   amperozida;   amperozidum
 alt_id: CHEBI:92913
 xref: CAS:75558-90-6;   Chemspider:66062;   DrugBank:DB08927;   Drug_Central:193;   HMDB:HMDB0248358;   LINCS:LSM-3159
 xref_mesh: MESH:C049058
 xref: PMID:10068147;   PMID:10512574;   PMID:10627067;   PMID:10975635;   PMID:12127016;   PMID:12213521;   PMID:18666714;   PMID:19850474;   PMID:2106131;   PMID:2111999;   PMID:2154737;   PMID:2224491;   PMID:2304894;   PMID:2304896;   PMID:2406715;   PMID:24134630;   PMID:2746728;   PMID:3751811;   PMID:7879876;   PMID:8050470;   PMID:8060520;   PMID:8255902;   PMID:8405119;   PMID:9443541;   PMID:9597673;   PMID:9631953;   PMID:9686999;   Patent:EP0517787;   Patent:WO9112805;   Wikipedia:Amperozide
 cyclic_relationship: is_conjugate_base_of CHEBI:180484


show annotations for term's descendants           Sort by:
amperozide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO amperozide inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:19583963 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      application 19722
        pharmaceutical 19556
          drug 19556
            protective agent 18263
              geroprotector 17404
                amperozide 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            heteroorganic entity 19541
                              organochalcogen compound 19301
                                organooxygen compound 19193
                                  carbon oxoacid 18681
                                    carboxylic acid 18678
                                      carboacyl group 17728
                                        univalent carboacyl group 17728
                                          carbamoyl group 17548
                                            carboxamide 17580
                                              monocarboxylic acid amide 15752
                                                urea 6228
                                                  ureas 6226
                                                    amperozide 1
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