|
G |
Acaca |
acetyl-CoA carboxylase alpha |
multiple interactions increases expression |
ISO EXP |
[lard co-treated with Cholesterol co-treated with Sucrose co-treated with Atrazine] results in increased expression of ACACA mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Ethinyl Estradiol] results in increased expression of ACACA mRNA Sucrose results in increased expression of ACACA mRNA [Dietary Fats co-treated with Sucrose] results in increased expression of ACACA mRNA; Biological Products inhibits the reaction [[Dietary Fats co-treated with Sucrose] results in increased expression of ACACA mRNA] |
CTD |
PMID:24440342 PMID:31175915 PMID:33930463 |
|
NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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|
G |
Acadm |
acyl-CoA dehydrogenase medium chain |
multiple interactions |
ISO |
[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of ACADM mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of ACADM mRNA] |
CTD |
PMID:24440342 |
|
NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
|
|
G |
Acly |
ATP citrate lyase |
multiple interactions |
ISO |
[lard co-treated with Cholesterol co-treated with Sucrose co-treated with Atrazine] results in increased expression of ACLY mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Ethinyl Estradiol] results in increased expression of ACLY mRNA |
CTD |
PMID:24440342 |
|
NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
|
|
G |
Acox1 |
acyl-CoA oxidase 1 |
multiple interactions |
ISO |
[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of ACOX1 mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of ACOX1 mRNA]; cypermethrin promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of ACOX1 mRNA]; Ethinyl Estradiol promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of ACOX1 mRNA] |
CTD |
PMID:24440342 |
|
NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232
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|
G |
Agt |
angiotensinogen |
multiple interactions |
EXP |
Sucrose inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; Sucrose inhibits the reaction [AGT protein binds to and results in increased localization of AGTR1A protein] |
CTD |
PMID:18267125 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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|
G |
Agtr1a |
angiotensin II receptor, type 1a |
multiple interactions |
EXP |
Sucrose inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; Sucrose inhibits the reaction [AGT protein binds to and results in increased localization of AGTR1A protein] |
CTD |
PMID:18267125 |
|
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
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|
G |
Alad |
aminolevulinate dehydratase |
multiple interactions |
ISO |
[Cadmium co-treated with Sucrose] affects the activity of ALAD protein |
CTD |
PMID:15454309 |
|
NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
|
|
G |
Alpl |
alkaline phosphatase, biomineralization associated |
multiple interactions |
EXP |
[Dietary Fats co-treated with Sucrose] results in increased expression of ALPL protein; gamma-sitosterol inhibits the reaction [[Dietary Fats co-treated with Sucrose] results in increased expression of ALPL protein] |
CTD |
PMID:30461321 |
|
NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
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|
G |
Ang |
angiogenin |
increases expression |
ISO |
Sucrose results in increased expression of ANG mRNA |
CTD |
PMID:23086926 |
|
NCBI chr15:24,312,711...24,323,361
|
|
G |
Ar |
androgen receptor |
multiple interactions |
ISO |
[2,4-Dichlorophenoxyacetic Acid co-treated with Glyphosate co-treated with lard co-treated with Cholesterol co-treated with Glucose co-treated with Sucrose co-treated with Fructose] results in decreased expression of AR protein; [Sucrose co-treated with Dietary Fats co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of AR mRNA |
CTD |
PMID:37516258 PMID:37615203 |
|
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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|
G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
ISO |
Sucrose results in increased activity of CASP3 protein 2,4-Dichlorophenoxyacetic Acid inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in increased expression of CASP3 mRNA]; [Sucrose co-treated with Dietary Fats] results in increased expression of CASP3 mRNA; EIF2AK2 protein affects the reaction [Sucrose results in increased activity of and results in increased cleavage of CASP3 protein]; EIF2AK2 protein affects the reaction [Sucrose results in increased cleavage of CASP3 protein]; GW 506033X inhibits the reaction [Sucrose results in increased activity of CASP3 protein]; Sucrose results in increased activity of and results in increased cleavage of CASP3 protein |
CTD |
PMID:15975986 PMID:27920257 PMID:37516258 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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|
G |
Cat |
catalase |
multiple interactions |
EXP ISO |
[Dietary Fats co-treated with Sucrose] results in decreased activity of CAT protein; gamma-sitosterol inhibits the reaction [[Dietary Fats co-treated with Sucrose] results in decreased activity of CAT protein] 2,4-Dichlorophenoxyacetic Acid inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in increased expression of CAT mRNA]; [Sucrose co-treated with Dietary Fats] results in increased expression of CAT mRNA |
CTD |
PMID:30461321 PMID:37516258 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
[Sucrose co-treated with Palmitates] results in increased expression of CCL2 mRNA |
CTD |
PMID:26895660 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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|
G |
Cpt1a |
carnitine palmitoyltransferase 1A |
multiple interactions |
ISO |
[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of CPT1A mRNA; [Sucrose co-treated with Oleic Acid] results in increased expression of CPT1A mRNA; [Sucrose co-treated with Palmitates] results in increased expression of CPT1A mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of CPT1A mRNA]; cypermethrin promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of CPT1A mRNA]; Ethinyl Estradiol promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of CPT1A mRNA] |
CTD |
PMID:24440342 PMID:26895660 |
|
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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G |
Creb1 |
cAMP responsive element binding protein 1 |
increases phosphorylation |
EXP |
Sucrose results in increased phosphorylation of CREB1 protein |
CTD |
PMID:12514263 |
|
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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|
G |
Cs |
citrate synthase |
multiple interactions |
ISO |
[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of CS mRNA |
CTD |
PMID:24440342 |
|
NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
decreases expression |
EXP |
Sucrose results in decreased expression of CYP1A1 protein |
CTD |
PMID:12680239 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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|
G |
Cyp4a1 |
cytochrome P450, family 4, subfamily a, polypeptide 1 |
multiple interactions |
EXP |
[Sucrose co-treated with Orotic Acid] results in increased expression of CYP4A1 mRNA |
CTD |
PMID:15670589 |
|
NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
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|
G |
Cyp4a2 |
cytochrome P450, family 4, subfamily a, polypeptide 2 |
multiple interactions |
EXP |
[Sucrose co-treated with Orotic Acid] results in increased expression of CYP4A2 mRNA |
CTD |
PMID:15670589 |
|
NCBI chr 5:128,922,355...128,934,188
Ensembl chr 5:128,923,615...128,934,165
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G |
Dgat1 |
diacylglycerol O-acyltransferase 1 |
multiple interactions |
ISO |
[lard co-treated with Cholesterol co-treated with Sucrose co-treated with cypermethrin] results in increased expression of DGAT1 mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Ethinyl Estradiol] results in increased expression of DGAT1 mRNA |
CTD |
PMID:24440342 |
|
NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299
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|
G |
Dgat2 |
diacylglycerol O-acyltransferase 2 |
multiple interactions |
ISO |
[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of DGAT2 mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of DGAT2 mRNA]; Ethinyl Estradiol promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of DGAT2 mRNA] |
CTD |
PMID:24440342 |
|
NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428
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|
G |
Dicer1 |
dicer 1 ribonuclease III |
multiple interactions |
ISO |
2,4-Dichlorophenoxyacetic Acid inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in increased expression of DICER1 mRNA]; [Sucrose co-treated with Dietary Fats] results in increased expression of DICER1 mRNA |
CTD |
PMID:37516258 |
|
NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965
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|
G |
Dnmt1 |
DNA methyltransferase 1 |
multiple interactions |
ISO |
2,4-Dichlorophenoxyacetic Acid inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in increased expression of DNMT1 mRNA]; [Sucrose co-treated with Dietary Fats] results in increased expression of DNMT1 mRNA |
CTD |
PMID:37516258 |
|
NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
|
|
G |
Drosha |
drosha ribonuclease III |
multiple interactions |
ISO |
2,4-Dichlorophenoxyacetic Acid inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in increased expression of DROSHA mRNA]; [Sucrose co-treated with Dietary Fats] results in increased expression of DROSHA mRNA |
CTD |
PMID:37516258 |
|
NCBI chr 2:61,864,886...61,976,688
Ensembl chr 2:61,864,970...61,976,688
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G |
Eif2ak2 |
eukaryotic translation initiation factor 2-alpha kinase 2 |
multiple interactions increases phosphorylation |
ISO |
EIF2AK2 protein affects the reaction [Sucrose results in increased activity of and results in increased cleavage of CASP3 protein]; EIF2AK2 protein affects the reaction [Sucrose results in increased cleavage of CASP3 protein]; EIF2AK2 protein affects the reaction [Sucrose results in increased expression of IL6 mRNA]; EIF2AK2 protein affects the reaction [Sucrose results in increased expression of NOS2 mRNA]; EIF2AK2 protein affects the reaction [Sucrose results in increased phosphorylation of RELA protein]; GW 506033X inhibits the reaction [Sucrose results in increased phosphorylation of EIF2AK2 protein] |
CTD |
PMID:27920257 |
|
NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971
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G |
Fas |
Fas cell surface death receptor |
multiple interactions |
EXP |
[Sucrose co-treated with Dietary Fats] results in decreased expression of FAS mRNA; [Sucrose co-treated with Dietary Fats] results in decreased expression of FAS protein; Resveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of FAS mRNA]; Resveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of FAS protein] |
CTD |
PMID:23127599 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
|
|
G |
Fasn |
fatty acid synthase |
multiple interactions increases expression |
ISO |
[Sucrose co-treated with Oleic Acid] results in increased expression of FASN mRNA; [Sucrose co-treated with Palmitates] results in increased expression of FASN mRNA Sucrose results in increased expression of FASN mRNA |
CTD |
PMID:26895660 PMID:33930463 |
|
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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|
G |
Fgf2 |
fibroblast growth factor 2 |
increases expression |
ISO |
Sucrose results in increased expression of FGF2 mRNA |
CTD |
PMID:26800359 |
|
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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|
G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
increases expression |
EXP |
Sucrose results in increased expression of G6PC1 mRNA |
CTD |
PMID:12514263 |
|
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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|
G |
Gapdh |
glyceraldehyde-3-phosphate dehydrogenase |
affects localization multiple interactions |
ISO |
Sucrose affects the localization of GAPDH protein GW 506033X inhibits the reaction [Sucrose affects the localization of GAPDH protein] |
CTD |
PMID:27920257 |
|
NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
|
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G |
Gnat3 |
G protein subunit alpha transducin 3 |
affects response to substance |
ISO |
GNAT3 protein affects the susceptibility to Sucrose |
CTD |
PMID:16740645 |
|
NCBI chr 4:17,162,500...17,212,283
Ensembl chr 4:17,162,490...17,212,283
|
|
G |
Got1 |
glutamic-oxaloacetic transaminase 1 |
multiple interactions |
EXP |
[Dietary Fats co-treated with Sucrose] results in increased expression of GOT1 protein; gamma-sitosterol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in increased expression of GOT1 protein] |
CTD |
PMID:30461321 |
|
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
|
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G |
Gpam |
glycerol-3-phosphate acyltransferase, mitochondrial |
multiple interactions |
ISO |
[lard co-treated with Cholesterol co-treated with Sucrose co-treated with Atrazine] results in increased expression of GPAM mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Ethinyl Estradiol] results in increased expression of GPAM mRNA |
CTD |
PMID:24440342 |
|
NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
|
|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP |
[Dietary Fats co-treated with Sucrose] results in increased expression of GPT protein; Biological Products inhibits the reaction [[Dietary Fats co-treated with Sucrose] results in increased expression of GPT protein]; gamma-sitosterol inhibits the reaction [[Dietary Fats co-treated with Sucrose] results in increased expression of GPT protein] |
CTD |
PMID:30461321 PMID:31175915 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
|
|
G |
Gpx1 |
glutathione peroxidase 1 |
multiple interactions |
EXP |
[Dietary Fats co-treated with Sucrose] results in decreased activity of GPX1 protein; gamma-sitosterol inhibits the reaction [[Dietary Fats co-treated with Sucrose] results in decreased activity of GPX1 protein]; Sucrose inhibits the reaction [Tobacco Smoke Pollution results in increased activity of GPX1 protein] |
CTD |
PMID:27470987 PMID:30461321 |
|
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
|
|
G |
Gsk3a |
glycogen synthase kinase 3 alpha |
decreases phosphorylation |
EXP |
Sucrose results in decreased phosphorylation of GSK3A protein |
CTD |
PMID:12514263 |
|
NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802
|
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
EXP ISO |
[Dietary Fats co-treated with Sucrose] results in decreased activity of GSR protein; [Tobacco Smoke Pollution co-treated with Sucrose] results in increased activity of GSR protein; gamma-sitosterol inhibits the reaction [[Dietary Fats co-treated with Sucrose] results in decreased activity of GSR protein] 2,4-Dichlorophenoxyacetic Acid inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in increased expression of GSR mRNA]; [Sucrose co-treated with Dietary Fats] results in increased expression of GSR mRNA |
CTD |
PMID:27470987 PMID:30461321 PMID:37516258 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
|
|
G |
Gsta1 |
glutathione S-transferase alpha 1 |
multiple interactions increases activity |
EXP |
Tobacco Smoke Pollution inhibits the reaction [Sucrose results in increased activity of GSTA1 protein] |
CTD |
PMID:27470987 |
|
NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
|
|
G |
Hbegf |
heparin-binding EGF-like growth factor |
increases expression |
ISO |
Sucrose results in increased expression of HBEGF mRNA |
CTD |
PMID:26800359 |
|
NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
|
|
G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
multiple interactions |
EXP |
[Dietary Fats co-treated with Sucrose] results in increased expression of HMGCR mRNA; [Dietary Fats co-treated with Sucrose] results in increased expression of HMGCR protein; Biological Products inhibits the reaction [[Dietary Fats co-treated with Sucrose] results in increased expression of HMGCR mRNA] |
CTD |
PMID:31175915 |
|
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
|
|
G |
Igf1r |
insulin-like growth factor 1 receptor |
multiple interactions |
EXP |
[Dietary Fats co-treated with Sucrose] results in decreased expression of IGF1R protein; gamma-sitosterol inhibits the reaction [[Dietary Fats co-treated with Sucrose] results in decreased expression of IGF1R protein] |
CTD |
PMID:30461321 |
|
NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
|
|
G |
Ikbke |
inhibitor of nuclear factor kappa B kinase subunit epsilon |
multiple interactions |
ISO |
IKBKE protein affects the reaction [Sucrose results in increased expression of NOS2 protein] |
CTD |
PMID:27920257 |
|
NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143
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|
G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
2,4-Dichlorophenoxyacetic Acid inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in increased expression of IL10 mRNA]; [Sucrose co-treated with Dietary Fats] results in increased expression of IL10 mRNA |
CTD |
PMID:37516258 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
|
|
G |
Il6 |
interleukin 6 |
increases expression multiple interactions |
ISO |
Sucrose results in increased expression of IL6 mRNA 2,4-Dichlorophenoxyacetic Acid inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in increased expression of IL6 mRNA]; [Sucrose co-treated with Dietary Fats] results in increased expression of IL6 mRNA; EIF2AK2 protein affects the reaction [Sucrose results in increased expression of IL6 mRNA]; RELA protein affects the reaction [Sucrose results in increased expression of IL6 mRNA] |
CTD |
PMID:27920257 PMID:37516258 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Ins1 |
insulin 1 |
multiple interactions |
EXP |
[Dietary Fats co-treated with Sucrose] affects the expression of INS1 protein; Quercetin affects the reaction [[Dietary Fats co-treated with Sucrose] affects the expression of INS1 protein] |
CTD |
PMID:24338341 |
|
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
|
|
G |
Ins2 |
insulin 2 |
increases expression |
ISO |
Sucrose results in increased expression of INS protein |
CTD |
PMID:1805284 |
|
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
|
|
G |
Irs1 |
insulin receptor substrate 1 |
multiple interactions |
ISO |
Oligosaccharides inhibits the reaction [[Sucrose co-treated with Dietary Fats] affects the expression of IRS1 mRNA]; Oligosaccharides inhibits the reaction [[Sucrose co-treated with Dietary Fats] affects the expression of IRS1 protein] |
CTD |
PMID:31181236 |
|
NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
|
|
G |
Itgav |
integrin subunit alpha V |
multiple interactions decreases expression |
EXP |
[Tobacco Smoke Pollution co-treated with Sucrose] results in decreased expression of ITGAV mRNA Sucrose results in decreased expression of ITGAV mRNA |
CTD |
PMID:27470987 |
|
NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639
|
|
G |
Itgb6 |
integrin subunit beta 6 |
increases expression |
EXP |
Sucrose results in increased expression of ITGB6 mRNA |
CTD |
PMID:27470987 |
|
NCBI chr 3:45,046,295...45,170,532
Ensembl chr 3:45,048,044...45,121,671
|
|
G |
Lct |
lactase |
increases expression |
EXP |
Sucrose results in increased expression of LCT mRNA |
CTD |
PMID:11242478 |
|
NCBI chr13:39,781,929...39,824,456
Ensembl chr13:39,781,929...39,824,456
|
|
G |
Ldlr |
low density lipoprotein receptor |
multiple interactions |
EXP |
[Sucrose co-treated with Dietary Fats] results in decreased expression of LDLR mRNA; [Sucrose co-treated with Dietary Fats] results in decreased expression of LDLR protein; resveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of LDLR mRNA]; resveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of LDLR protein] |
CTD |
PMID:23127599 |
|
NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
|
|
G |
Lepr |
leptin receptor |
affects abundance |
ISO |
LEPR affects the abundance of Sucrose |
CTD |
PMID:20567778 |
|
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO EXP |
Sucrose results in decreased phosphorylation of and results in decreased activity of MAPK1 protein Sucrose results in increased phosphorylation of and results in increased activity of MAPK1 protein |
CTD |
PMID:15975986 PMID:18267125 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions |
ISO |
Sucrose results in increased phosphorylation of and results in increased activity of MAPK14 protein |
CTD |
PMID:15975986 |
|
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO EXP |
Sucrose results in decreased phosphorylation of and results in decreased activity of MAPK3 protein Sucrose results in increased phosphorylation of and results in increased activity of MAPK3 protein |
CTD |
PMID:15975986 PMID:18267125 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
Oligosaccharides inhibits the reaction [[Sucrose co-treated with Dietary Fats] affects the expression of MAPK8 mRNA] |
CTD |
PMID:31181236 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions |
ISO |
[Oligosaccharides co-treated with Sucrose co-treated with Dietary Fats] affects the expression of MAPK9 mRNA |
CTD |
PMID:31181236 |
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NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
multiple interactions increases expression |
ISO |
RELA protein affects the reaction [Sucrose results in increased expression of MCL1 mRNA] |
CTD |
PMID:27920257 |
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NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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G |
Mki67 |
marker of proliferation Ki-67 |
multiple interactions |
ISO |
2,4-Dichlorophenoxyacetic Acid inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in increased expression of MKI67 mRNA]; [Sucrose co-treated with Dietary Fats] results in increased expression of MKI67 mRNA |
CTD |
PMID:37516258 |
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NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Mlxip |
MLX interacting protein |
affects localization multiple interactions increases expression |
ISO |
Sucrose affects the localization of MLXIP protein pyrrolidine dithiocarbamic acid inhibits the reaction [Sucrose affects the localization of MLXIP protein] Sucrose results in increased expression of MLXIP mRNA |
CTD |
PMID:33930463 |
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NCBI chr12:33,128,524...33,192,300
Ensembl chr12:33,128,520...33,192,374
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G |
Mlxipl |
MLX interacting protein-like |
multiple interactions |
ISO |
[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of MLXIPL mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of MLXIPL mRNA] |
CTD |
PMID:24440342 |
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NCBI chr12:21,541,608...21,577,120
Ensembl chr12:21,543,576...21,577,112
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G |
Nfkbia |
NFKB inhibitor alpha |
increases expression multiple interactions |
ISO |
Sucrose results in increased expression of NFKBIA mRNA RELA protein affects the reaction [Sucrose results in increased expression of NFKBIA mRNA]; Sucrose results in decreased expression of and results in increased phosphorylation of NFKBIA protein |
CTD |
PMID:27920257 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos2 |
nitric oxide synthase 2 |
increases expression multiple interactions |
ISO |
Sucrose results in increased expression of NOS2 mRNA; Sucrose results in increased expression of NOS2 protein EIF2AK2 protein affects the reaction [Sucrose results in increased expression of NOS2 mRNA]; GW 506033X inhibits the reaction [Sucrose results in increased expression of NOS2 mRNA]; IKBKE protein affects the reaction [Sucrose results in increased expression of NOS2 protein]; RELA protein affects the reaction [Sucrose results in increased expression of NOS2 mRNA] |
CTD |
PMID:27920257 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions decreases expression |
EXP |
Chromium inhibits the reaction [Sucrose results in decreased expression of NOS3 protein] |
CTD |
PMID:17215582 |
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NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Nts |
neurotensin |
multiple interactions decreases activity |
ISO |
Sucrose promotes the reaction [bisindolylmaleimide I results in increased activity of NTS protein]; Sucrose promotes the reaction [Tetradecanoylphorbol Acetate results in decreased activity of NTS protein] Sucrose results in decreased activity of NTS protein |
CTD |
PMID:18313772 |
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NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
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G |
Pck1 |
phosphoenolpyruvate carboxykinase 1 |
multiple interactions |
EXP |
[Dietary Fats co-treated with Sucrose] results in increased expression of PCK1 mRNA; Biological Products inhibits the reaction [[Dietary Fats co-treated with Sucrose] results in increased expression of PCK1 mRNA] |
CTD |
PMID:31175915 |
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NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
ISO |
[2,4-Dichlorophenoxyacetic Acid co-treated with Glyphosate] promotes the reaction [[lard co-treated with Cholesterol co-treated with Glucose co-treated with Sucrose co-treated with Fructose] results in decreased expression of PCNA protein]; [2,4-Dichlorophenoxyacetic Acid co-treated with lard co-treated with Cholesterol co-treated with Glucose co-treated with Sucrose co-treated with Fructose] results in decreased expression of PCNA protein; [Glyphosate co-treated with lard co-treated with Cholesterol co-treated with Glucose co-treated with Sucrose co-treated with Fructose] results in decreased expression of PCNA protein; [lard co-treated with Cholesterol co-treated with Glucose co-treated with Sucrose co-treated with Fructose] results in decreased expression of PCNA protein |
CTD |
PMID:37615203 |
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NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pik3ca |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
multiple interactions |
ISO |
Oligosaccharides inhibits the reaction [[Sucrose co-treated with Dietary Fats] affects the expression of PIK3CA mRNA] |
CTD |
PMID:31181236 |
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NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
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G |
Pklr |
pyruvate kinase L/R |
multiple interactions |
ISO |
[lard co-treated with Cholesterol co-treated with Sucrose co-treated with Atrazine] results in increased expression of PKLR mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with cypermethrin] results in increased expression of PKLR mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Ethinyl Estradiol] results in increased expression of PKLR mRNA |
CTD |
PMID:24440342 |
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NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
EXP ISO |
[Sucrose co-treated with Orotic Acid] results in decreased expression of PPARA protein [lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of PPARA mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of PPARA mRNA]; cypermethrin promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of PPARA mRNA]; Ethinyl Estradiol promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of PPARA mRNA] |
CTD |
PMID:15670589 PMID:24440342 |
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NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
ISO |
[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of PPARG mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of PPARG mRNA] |
CTD |
PMID:24440342 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Prkaa2 |
protein kinase AMP-activated catalytic subunit alpha 2 |
multiple interactions |
EXP |
[Dietary Fats co-treated with Sucrose] results in decreased expression of PRKAA2 mRNA; Biological Products inhibits the reaction [[Dietary Fats co-treated with Sucrose] results in decreased expression of PRKAA2 mRNA] |
CTD |
PMID:31175915 |
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NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543
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G |
Prkg1 |
protein kinase cGMP-dependent 1 |
decreases expression |
EXP |
Sucrose results in decreased expression of PRKG1 protein |
CTD |
PMID:17215582 |
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NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
EXP |
Sucrose inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein] |
CTD |
PMID:18267125 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rac1 |
Rac family small GTPase 1 |
increases activity |
ISO |
Sucrose results in increased activity of RAC1 protein |
CTD |
PMID:15975986 |
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NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions affects localization increases phosphorylation |
ISO |
EIF2AK2 protein affects the reaction [Sucrose results in increased phosphorylation of RELA protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Sucrose affects the localization of RELA protein]; RELA protein affects the reaction [Sucrose results in increased expression of IL6 mRNA]; RELA protein affects the reaction [Sucrose results in increased expression of MCL1 mRNA]; RELA protein affects the reaction [Sucrose results in increased expression of NFKBIA mRNA]; RELA protein affects the reaction [Sucrose results in increased expression of NOS2 mRNA] |
CTD |
PMID:27920257 PMID:33930463 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Rnh1 |
ribonuclease/angiogenin inhibitor 1 |
increases expression |
ISO |
Sucrose results in increased expression of RNH1 mRNA |
CTD |
PMID:23086926 |
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NCBI chr 1:196,269,293...196,281,763
Ensembl chr 1:196,269,293...196,281,910
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G |
Rxra |
retinoid X receptor alpha |
multiple interactions |
EXP |
[Sucrose co-treated with Orotic Acid] results in decreased expression of RXRA protein |
CTD |
PMID:15670589 |
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NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
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G |
Scarb1 |
scavenger receptor class B, member 1 |
multiple interactions |
EXP |
[Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 mRNA; [Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 protein; resveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 mRNA]; resveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 protein] |
CTD |
PMID:23127599 |
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NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
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G |
Scd |
stearoyl-CoA desaturase |
multiple interactions increases expression increases activity |
ISO EXP |
[lard co-treated with Cholesterol co-treated with Sucrose co-treated with Atrazine] results in increased expression of SCD1 mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with cypermethrin] results in increased expression of SCD1 mRNA; [Sucrose co-treated with Oleic Acid] results in increased expression of SCD1 mRNA; [Sucrose co-treated with Palmitates] results in increased expression of SCD1 mRNA Sucrose results in increased expression of SCD1 mRNA Sucrose results in increased activity of SCD1 protein |
CTD |
PMID:22413010 PMID:24440342 PMID:26895660 |
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NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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G |
Si |
sucrase-isomaltase |
increases expression |
EXP |
Sucrose results in increased expression of SI mRNA |
CTD |
PMID:10222385 PMID:11242478 |
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NCBI chr 2:157,505,893...157,586,228
Ensembl chr 2:157,506,342...157,585,260
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G |
Slc2a2 |
solute carrier family 2 member 2 |
increases expression multiple interactions |
EXP ISO |
Sucrose results in increased expression of SLC2A2 mRNA [lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of SLC2A2 mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of SLC2A2 mRNA]; cypermethrin promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of SLC2A2 mRNA]; Ethinyl Estradiol promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of SLC2A2 mRNA] |
CTD |
PMID:10222385 PMID:24440342 |
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NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
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G |
Slc2a4 |
solute carrier family 2 member 4 |
decreases localization multiple interactions |
ISO EXP |
Sucrose results in decreased localization of SLC2A4 protein Chromium inhibits the reaction [Sucrose results in decreased localization of SLC2A4 protein] Oligosaccharides inhibits the reaction [[Sucrose co-treated with Dietary Fats] affects the expression of SLC2A4 mRNA]; Oligosaccharides inhibits the reaction [[Sucrose co-treated with Dietary Fats] affects the expression of SLC2A4 protein] [Dietary Fats co-treated with Sucrose] results in decreased expression of SLC2A4 protein; gamma-sitosterol inhibits the reaction [[Dietary Fats co-treated with Sucrose] results in decreased expression of SLC2A4 protein] |
CTD |
PMID:18806091 PMID:30461321 PMID:31181236 |
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NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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G |
Slc2a5 |
solute carrier family 2 member 5 |
increases expression |
EXP |
Sucrose results in increased expression of SLC2A5 mRNA |
CTD |
PMID:9124564 PMID:10222385 |
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NCBI chr 5:160,583,055...160,609,994
Ensembl chr 5:160,583,234...160,611,106
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G |
Slc39a4 |
solute carrier family 39 member 4 |
multiple interactions |
ISO |
Sucrose inhibits the reaction [Zinc results in increased degradation of SLC39A4 protein] |
CTD |
PMID:17202136 |
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NCBI chr 7:108,333,368...108,337,553
Ensembl chr 7:108,333,381...108,337,553
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G |
Slc5a1 |
solute carrier family 5 member 1 |
increases expression |
EXP |
Sucrose results in increased expression of SLC5A1 mRNA; Sucrose results in increased expression of SLC5A1 protein |
CTD |
PMID:8048533 PMID:10222385 |
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NCBI chr14:77,553,990...77,618,589
Ensembl chr14:77,553,843...77,618,547
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
EXP ISO |
[Dietary Fats co-treated with Sucrose] results in decreased activity of SOD1 protein; gamma-sitosterol inhibits the reaction [[Dietary Fats co-treated with Sucrose] results in decreased activity of SOD1 protein]; Sucrose inhibits the reaction [Copper inhibits the reaction [Trientine results in decreased activity of SOD1 protein]] 2,4-Dichlorophenoxyacetic Acid inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in increased expression of SOD1 mRNA]; [Sucrose co-treated with Dietary Fats] results in increased expression of SOD1 mRNA |
CTD |
PMID:22362149 PMID:30461321 PMID:37516258 |
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions |
ISO EXP |
[lard co-treated with Cholesterol co-treated with Sucrose co-treated with Atrazine] results in increased expression of SREBF1 mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Ethinyl Estradiol] results in increased expression of SREBF1 mRNA [Dietary Fats co-treated with Sucrose] results in increased expression of SREBF1 mRNA; [Dietary Fats co-treated with Sucrose] results in increased expression of SREBF1 protein; Biological Products inhibits the reaction [[Dietary Fats co-treated with Sucrose] results in increased expression of SREBF1 mRNA]; Biological Products inhibits the reaction [[Dietary Fats co-treated with Sucrose] results in increased expression of SREBF1 protein] |
CTD |
PMID:24440342 PMID:31175915 |
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NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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G |
Sri |
sorcin |
decreases expression multiple interactions |
ISO |
Sucrose results in decreased expression of SRI mRNA; Sucrose results in decreased expression of SRI protein pyrrolidine dithiocarbamic acid inhibits the reaction [Sucrose results in decreased expression of SRI protein] |
CTD |
PMID:33930463 |
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NCBI chr 4:25,973,493...25,997,879
Ensembl chr 4:25,966,750...25,998,077
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G |
Tac1 |
tachykinin, precursor 1 |
multiple interactions |
EXP |
Sucrose inhibits the reaction [TAC1 protein affects the localization of TACR1 protein] |
CTD |
PMID:7524481 |
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NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
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G |
Tacr1 |
tachykinin receptor 1 |
multiple interactions |
EXP |
Sucrose inhibits the reaction [TAC1 protein affects the localization of TACR1 protein] |
CTD |
PMID:7524481 |
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NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
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G |
Tas1r2 |
taste 1 receptor member 2 |
multiple interactions |
ISO |
Sucrose binds to and results in increased activity of TAS1R2 protein; Sucrose results in increased activity of [TAS1R2 protein binds to TAS1R3 protein] |
CTD |
PMID:20173092 |
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NCBI chr 5:151,909,617...151,925,760
Ensembl chr 5:151,830,701...151,925,345
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G |
Tas1r3 |
taste 1 receptor member 3 |
multiple interactions |
ISO |
Sucrose results in increased activity of [TAS1R2 protein binds to TAS1R3 protein] |
CTD |
PMID:20173092 |
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NCBI chr 5:166,468,703...166,472,759
Ensembl chr 5:166,469,589...166,472,742
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
2,4-Dichlorophenoxyacetic Acid inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in increased expression of TNF mRNA]; [Sucrose co-treated with Dietary Fats] results in increased expression of TNF mRNA |
CTD |
PMID:37516258 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
2,4-Dichlorophenoxyacetic Acid inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in increased expression of TP53 mRNA]; [Sucrose co-treated with Dietary Fats] results in increased expression of TP53 mRNA; Sucrose results in increased phosphorylation of and affects the localization of TRP53 protein |
CTD |
PMID:15975986 PMID:37516258 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Vasp |
vasodilator-stimulated phosphoprotein |
multiple interactions decreases phosphorylation |
EXP |
Chromium inhibits the reaction [Sucrose results in decreased phosphorylation of VASP protein] |
CTD |
PMID:17215582 |
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NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
[Gallic Acid co-treated with Butyric Acid co-treated with verbascose] affects the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased secretion of IL1B protein]; verbascose affects the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased secretion of IL1B protein]; verbascose inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased secretion of CXCL8 protein]; verbascose promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased secretion of TNF protein] |
CTD |
PMID:33130239 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
[Gallic Acid co-treated with Butyric Acid co-treated with verbascose] affects the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased secretion of IL1B protein]; verbascose affects the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased secretion of IL1B protein] |
CTD |
PMID:33130239 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
verbascose promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased secretion of TNF protein] |
CTD |
PMID:33130239 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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