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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:isoorientin
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Accession:CHEBI:17965 term browser browse the term
Definition:A flavone C-glycoside consisting of luteolin having a beta-D-glucosyl residue at the 6-position.
Synonyms:exact_synonym: (1S)-1,5-anhydro-1-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-6-yl]-D-glucitol
 related_synonym: 2-(3,4-dihydroxyphenyl)-6-beta-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one;   Formula=C21H20O11;   Homoorientin;   InChI=1S/C21H20O11/c22-6-14-17(27)19(29)20(30)21(32-14)16-11(26)5-13-15(18(16)28)10(25)4-12(31-13)7-1-2-8(23)9(24)3-7/h1-5,14,17,19-24,26-30H,6H2/t14-,17-,19+,20-,21+/m1/s1;   InChIKey=ODBRNZZJSYPIDI-VJXVFPJBSA-N;   Luteolin-6-C-beta-D-glucoside;   SMILES=OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1c(O)cc2oc(cc(=O)c2c1O)-c1ccc(O)c(O)c1
 alt_id: CHEBI:14471;   CHEBI:24905;   CHEBI:6034
 xref: CAS:4261-42-1;   KEGG:C01821;   KNApSAcK:C00001055;   LIPID_MAPS_instance:LMPK12110469
 xref_mesh: MESH:C057912
 xref: PMID:21080643;   PMID:22529049;   PMID:22948221;   PMID:22980875;   PMID:23026832;   PMID:23220614;   Reaxys:68256;   Wikipedia:Isoorientin
 cyclic_relationship: is_conjugate_acid_of CHEBI:58333


show annotations for term's descendants           Sort by:
isoorientin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases expression ISO homoorientin results in decreased expression of ABCC1 protein CTD PMID:34019859 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP homoorientin inhibits the reaction [Ethanol results in increased expression of ACTA2 protein] CTD PMID:22446813 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 ISO homoorientin results in decreased phosphorylation of AKT1 protein
homoorientin promotes the reaction [Zinc Oxide analog results in decreased phosphorylation of AKT1 protein]; Zinc Oxide analog promotes the reaction [homoorientin results in decreased phosphorylation of AKT1 protein]		 CTD PMID:24374571 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP homoorientin inhibits the reaction [Ethanol results in increased expression of BCL2 mRNA] CTD PMID:22446813 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO homoorientin results in increased expression of CDH1 protein CTD PMID:34019859 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 decreases expression ISO homoorientin results in decreased expression of CDH2 protein CTD PMID:34019859 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO homoorientin results in decreased expression of CTNNB1 protein CTD PMID:34019859 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation ISO homoorientin results in decreased phosphorylation of GSK3B protein CTD PMID:34019859 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP homoorientin inhibits the reaction [Ethanol results in increased expression of IL6 protein] CTD PMID:22446813 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 decreases expression ISO homoorientin results in decreased expression of LEF1 protein CTD PMID:34019859 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO homoorientin promotes the reaction [Zinc Oxide analog results in decreased phosphorylation of MAPK1 protein]; Zinc Oxide analog promotes the reaction [homoorientin results in decreased phosphorylation of MAPK1 protein] CTD PMID:24374571 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO homoorientin promotes the reaction [Zinc Oxide analog results in decreased phosphorylation of MAPK3 protein]; Zinc Oxide analog promotes the reaction [homoorientin results in decreased phosphorylation of MAPK3 protein] CTD PMID:24374571 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO homoorientin results in decreased expression of MMP7 protein CTD PMID:34019859 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP homoorientin inhibits the reaction [Ethanol results in increased activity of MPO protein] CTD PMID:22446813 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO homoorientin results in decreased expression of POU5F1 protein CTD PMID:34019859 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Snai2 snail family transcriptional repressor 2 decreases expression ISO homoorientin results in decreased expression of SNAI2 protein CTD PMID:34019859 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression ISO homoorientin results in decreased expression of SOX2 protein CTD PMID:34019859 NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases expression
decreases phosphorylation		 ISO homoorientin results in decreased expression of STAT3 protein modified form
homoorientin results in decreased phosphorylation of STAT3 protein		 CTD PMID:34019859 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tcf7 transcription factor 7 decreases expression ISO homoorientin results in decreased expression of TCF7 protein CTD PMID:34019859 NCBI chr10:36,423,443...36,454,350
Ensembl chr10:36,423,445...36,453,535 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP homoorientin inhibits the reaction [Ethanol results in increased expression of TGFB1 protein] CTD PMID:22446813 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP homoorientin inhibits the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:22446813 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vim vimentin decreases expression ISO homoorientin results in decreased expression of VIM protein CTD PMID:34019859 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        immunomodulator 15067
          luteolin 240
            isoorientin 22
              3''-oxohomoorientin(2-) 0
              7-O-(6-feruoylglucosyl)isoorientin 0
              7-O-(6-sinapoylglucosyl)isoorientin 0
              7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucosyl]isoorientin 0
              isoorientin 2''-O-glucoside 0
              isoorientin 2''-O-rhamnoside + 0
              isoorientin 7,3'-dimethyl ether 0
              isoorientin 7-O-glucoside 0
              swertiajaponin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic heterocyclic compound 18868
                                  oxacycle 17903
                                    benzopyran 11971
                                      1-benzopyran 11725
                                        flavonoid 7225
                                          anthoxanthin 4584
                                            flavones 4584
                                              hydroxyflavone 4561
                                                3'-hydroxyflavonoid 307
                                                  luteolin 240
                                                    isoorientin 22
                                                      3''-oxohomoorientin(2-) 0
                                                      7-O-(6-feruoylglucosyl)isoorientin 0
                                                      7-O-(6-sinapoylglucosyl)isoorientin 0
                                                      7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucosyl]isoorientin 0
                                                      isoorientin 2''-O-glucoside 0
                                                      isoorientin 2''-O-rhamnoside + 0
                                                      isoorientin 7,3'-dimethyl ether 0
                                                      isoorientin 7-O-glucoside 0
                                                      swertiajaponin 0
paths to the root