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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:diisopropyl fluorophosphate
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Accession:CHEBI:17941 term browser browse the term
Definition:A dialkyl phosphate that has formula C6H14FO3P.
Synonyms:exact_synonym: bis(propan-2-yl) fluorophosphate
 related_synonym: DFP;   Diisopropoxyphosphoryl fluoride;   Diisopropyl fluorophosphonate;   Diisopropyl phosphofluoridate;   Diisopropyl phosphorofluoridate;   Diisopropylfluorophosphate;   Diisopropylfluorophosphoric acid ester;   Diisopropylphosphorofluoridate;   Fluorodiisopropyl phosphate;   Formula=C6H14FO3P;   InChI=1S/C6H14FO3P/c1-5(2)9-11(7,8)10-6(3)4/h5-6H,1-4H3;   InChIKey=MUCZHBLJLSDCSD-UHFFFAOYSA-N;   Isofluorphate;   Isoflurophate;   Isoflurophosphate;   Isopropyl fluophosphate;   Isopropyl phosphorofluoridate;   Neoglaucit;   O,O'-Diisopropyl phosphoryl fluoride;   SMILES=CC(C)OP(F)(=O)OC(C)C
 alt_id: CHEBI:14166;   CHEBI:4598
 xref: CAS:55-91-4;   DrugBank:DB00677;   Drug_Central:1494;   KEGG:C00202;   KEGG:D00043
 xref_mesh: MESH:D007531
 xref: Wikipedia:Isoflurophate


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diisopropyl fluorophosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadac arylacetamide deacetylase multiple interactions ISO Isoflurophate inhibits the reaction [AADAC protein results in decreased acetylation of Rifabutin]; Isoflurophate inhibits the reaction [AADAC protein results in decreased acetylation of Rifampin]; Isoflurophate inhibits the reaction [AADAC protein results in decreased acetylation of rifapentine] CTD PMID:21856291 NCBI chr 2:144,163,436...144,186,086
Ensembl chr 2:144,135,319...144,174,734 		JBrowse link
G Ache acetylcholinesterase multiple interactions
decreases activity
decreases response to substance
decreases expression		 ISO
EXP		 Fullerenes analog inhibits the reaction [Isoflurophate results in decreased activity of ACHE protein]; Glucosides inhibits the reaction [Isoflurophate results in decreased activity of ACHE protein]; N,N'-monomethylenebis(pyridiniumaldoxime) inhibits the reaction [Isoflurophate results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Isoflurophate results in decreased activity of ACHE protein]; Oximes inhibits the reaction [Isoflurophate results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Isoflurophate results in decreased activity of ACHE protein]; Trimedoxime inhibits the reaction [Isoflurophate results in decreased activity of ACHE protein]
ACHE protein results in decreased susceptibility to Isoflurophate; ACHE results in decreased susceptibility to Isoflurophate
Corticosterone inhibits the reaction [Isoflurophate results in decreased activity of ACHE protein]; Isoflurophate binds to and results in increased phosphorylation of and results in decreased activity of ACHE protein
Isoflurophate analog results in decreased activity of ACHE protein; Isoflurophate results in decreased activity of ACHE protein
Isoflurophate results in decreased expression of ACHE mRNA		 CTD PMID:1609424 PMID:3215484 PMID:7150809 PMID:7178195 PMID:7234437 More... NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Aif1 allograft inflammatory factor 1 increases expression EXP Isoflurophate results in increased expression of AIF1 protein CTD PMID:28329845 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668 		JBrowse link
G Alb albumin affects binding
increases expression		 ISO
EXP		 Isoflurophate binds to ALB protein
Isoflurophate results in increased expression of ALB protein		 CTD PMID:15525694 PMID:17188226 PMID:35500718 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Apoh apolipoprotein H increases expression EXP Isoflurophate results in increased expression of APOH protein CTD PMID:30389396 NCBI chr10:93,342,435...93,356,334
Ensembl chr10:93,310,977...93,356,329 		JBrowse link
G Bche butyrylcholinesterase multiple interactions
decreases activity
decreases response to substance		 ISO
EXP		 Glucosides inhibits the reaction [Isoflurophate results in decreased activity of BCHE protein]; Isoflurophate inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]; pralidoxime inhibits the reaction [Isoflurophate inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]]; pralidoxime inhibits the reaction [Isoflurophate results in decreased activity of BCHE protein]
diacetylmonoxime inhibits the reaction [Isoflurophate results in decreased activity of BCHE protein]
BCHE protein results in decreased susceptibility to Isoflurophate		 CTD PMID:1276991 PMID:4631366 PMID:7150809 PMID:16213467 PMID:17698511 More... NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression
multiple interactions		 EXP Isoflurophate results in decreased expression of BDNF protein
Ketamine inhibits the reaction [Isoflurophate results in decreased expression of BDNF protein]		 CTD PMID:32592718 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
decreases expression		 EXP
ISO		 Corticosterone promotes the reaction [Isoflurophate results in increased expression of CCL2 mRNA]
[Corticosterone co-treated with Isoflurophate] results in increased expression of CCL2 mRNA; CORT protein inhibits the reaction [Isoflurophate results in decreased expression of CCL2 mRNA]; Corticosterone promotes the reaction [Isoflurophate results in increased expression of CCL2 mRNA]		 CTD PMID:28500787 PMID:28782715 PMID:29846716 PMID:30339781 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression EXP Isoflurophate results in increased expression of CDKN2A protein CTD PMID:38745692 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cort cortistatin multiple interactions ISO [CORT protein co-treated with Isoflurophate] affects the secretion of IL5 protein; [CORT protein co-treated with Isoflurophate] results in decreased secretion of IL4 protein; [CORT protein co-treated with Isoflurophate] results in increased expression of LIF mRNA; [CORT protein co-treated with Pyridostigmine Bromide co-treated with DEET co-treated with Isoflurophate] affects the secretion of IL10 protein; [Pyridostigmine Bromide co-treated with DEET] affects the reaction [[CORT protein co-treated with Isoflurophate] affects the secretion of IL5 protein]; [Pyridostigmine Bromide co-treated with DEET] inhibits the reaction [[CORT protein co-treated with Isoflurophate] results in increased expression of LIF mRNA]; [Pyridostigmine Bromide co-treated with DEET] promotes the reaction [CORT protein inhibits the reaction [Isoflurophate results in increased expression of IL1B mRNA]]; [Pyridostigmine Bromide co-treated with DEET] promotes the reaction [CORT protein inhibits the reaction [Isoflurophate results in increased expression of IL6 mRNA]]; [Pyridostigmine Bromide co-treated with DEET] promotes the reaction [CORT protein inhibits the reaction [Isoflurophate results in increased expression of OSM mRNA]]; CORT protein inhibits the reaction [Isoflurophate results in decreased expression of CCL2 mRNA]; CORT protein inhibits the reaction [Isoflurophate results in decreased expression of TNF mRNA]; CORT protein inhibits the reaction [Isoflurophate results in increased expression of IL10 mRNA]; CORT protein inhibits the reaction [Isoflurophate results in increased expression of IL1B mRNA]; CORT protein inhibits the reaction [Isoflurophate results in increased expression of IL6 mRNA]; CORT protein inhibits the reaction [Isoflurophate results in increased expression of OSM mRNA]; CORT protein inhibits the reaction [Isoflurophate results in increased secretion of CXCL1 protein]; CORT protein inhibits the reaction [Isoflurophate results in increased secretion of IL6 protein] CTD PMID:30339781 NCBI chr 5:159,560,591...159,562,032 JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression
multiple interactions		 EXP Isoflurophate results in increased expression of CXCL1 protein
AEOL 10150 inhibits the reaction [Isoflurophate results in increased expression of CXCL1 protein]		 CTD PMID:29272548 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases secretion
multiple interactions		 ISO Isoflurophate results in increased secretion of CXCL1 protein
[Pyridostigmine Bromide co-treated with DEET] inhibits the reaction [Isoflurophate results in increased secretion of CXCL1 protein]; CORT protein inhibits the reaction [Isoflurophate results in increased secretion of CXCL1 protein]		 CTD PMID:30339781 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Ddc dopa decarboxylase affects binding ISO Isoflurophate binds to [DDC protein binds to Pyridoxal Phosphate]; Isoflurophate binds to DDC protein CTD PMID:35151785 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208 		JBrowse link
G Fga fibrinogen alpha chain increases expression EXP Isoflurophate results in increased expression of FGA protein CTD PMID:30389396 NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528 		JBrowse link
G Fgg fibrinogen gamma chain increases expression EXP Isoflurophate results in increased expression of FGG protein CTD PMID:30389396 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322 		JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B decreases expression EXP Isoflurophate results in decreased expression of FKBP1B protein CTD PMID:30859209 NCBI chr 6:27,832,128...27,850,600
Ensembl chr 6:27,838,802...27,848,653 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Isoflurophate results in increased expression of FOS mRNA; Isoflurophate results in increased expression of FOS protein CTD PMID:35500718 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression EXP Isoflurophate results in increased expression of FOSB mRNA; Isoflurophate results in increased expression of FOSB protein alternative form CTD PMID:35500718 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Gad1 glutamate decarboxylase 1 affects binding ISO Isoflurophate binds to [GAD1 protein binds to Pyridoxal Phosphate]; Isoflurophate binds to GAD1 protein CTD PMID:35151785 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333 		JBrowse link
G Gad2 glutamate decarboxylase 2 affects binding ISO Isoflurophate binds to [GAD2 protein binds to Pyridoxal Phosphate]; Isoflurophate binds to GAD2 protein CTD PMID:35151785 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155 		JBrowse link
G Hdc histidine decarboxylase affects binding ISO Isoflurophate binds to [HDC protein binds to Pyridoxal Phosphate]; Isoflurophate binds to HDC protein CTD PMID:35151785 NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341 		JBrowse link
G Homer1 homer scaffold protein 1 increases expression EXP Isoflurophate results in increased expression of HOMER1 mRNA CTD PMID:35500718 NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785 		JBrowse link
G Hp haptoglobin increases expression
decreases expression		 EXP Isoflurophate results in increased expression of HP protein
Isoflurophate results in decreased expression of HP protein		 CTD PMID:30389396 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523 		JBrowse link
G IgG-2a gamma-2a immunoglobulin heavy chain increases expression EXP Isoflurophate results in increased expression of IGG-2A protein CTD PMID:30389396
G Il10 interleukin 10 multiple interactions
increases expression		 ISO [CORT protein co-treated with Pyridostigmine Bromide co-treated with DEET co-treated with Isoflurophate] affects the secretion of IL10 protein; [Pyridostigmine Bromide co-treated with DEET co-treated with Isoflurophate] affects the secretion of IL10 protein; [Pyridostigmine Bromide co-treated with DEET] inhibits the reaction [Isoflurophate results in increased expression of IL10 mRNA]; CORT protein inhibits the reaction [Isoflurophate results in increased expression of IL10 mRNA] CTD PMID:30339781 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 EXP
ISO		 Isoflurophate results in increased expression of IL1B mRNA
Corticosterone promotes the reaction [Isoflurophate results in increased expression of IL1B mRNA]
[Corticosterone co-treated with Isoflurophate] results in increased expression of IL1B mRNA; [Pyridostigmine Bromide co-treated with DEET] inhibits the reaction [Isoflurophate results in increased expression of IL1B mRNA]; [Pyridostigmine Bromide co-treated with DEET] promotes the reaction [CORT protein inhibits the reaction [Isoflurophate results in increased expression of IL1B mRNA]]; CORT protein inhibits the reaction [Isoflurophate results in increased expression of IL1B mRNA]		 CTD PMID:28500787 PMID:28782715 PMID:29846716 PMID:30339781 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 increases secretion ISO Isoflurophate results in increased secretion of IL2 protein CTD PMID:30339781 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il4 interleukin 4 decreases secretion
multiple interactions		 ISO Isoflurophate results in decreased secretion of IL4 protein
[CORT protein co-treated with Isoflurophate] results in decreased secretion of IL4 protein		 CTD PMID:30339781 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 multiple interactions
decreases secretion		 ISO [CORT protein co-treated with Isoflurophate] affects the secretion of IL5 protein; [Pyridostigmine Bromide co-treated with DEET] affects the reaction [[CORT protein co-treated with Isoflurophate] affects the secretion of IL5 protein]
Isoflurophate results in decreased secretion of IL5 protein		 CTD PMID:30339781 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
increases secretion		 EXP
ISO		 Isoflurophate results in increased expression of IL6 mRNA; Isoflurophate results in increased expression of IL6 protein
AEOL 10150 inhibits the reaction [Isoflurophate results in increased expression of IL6 protein]; Corticosterone inhibits the reaction [Isoflurophate results in increased expression of IL6 mRNA]
Isoflurophate results in increased secretion of IL6 protein
[Pyridostigmine Bromide co-treated with DEET] inhibits the reaction [Isoflurophate results in increased expression of IL6 mRNA]; [Pyridostigmine Bromide co-treated with DEET] inhibits the reaction [Isoflurophate results in increased secretion of IL6 protein]; [Pyridostigmine Bromide co-treated with DEET] promotes the reaction [CORT protein inhibits the reaction [Isoflurophate results in increased expression of IL6 mRNA]]; CORT protein inhibits the reaction [Isoflurophate results in increased expression of IL6 mRNA]; CORT protein inhibits the reaction [Isoflurophate results in increased secretion of IL6 protein]; Isoflurophate inhibits the reaction [Corticosterone results in decreased expression of IL6 mRNA]		 CTD PMID:28500787 PMID:28782715 PMID:29272548 PMID:29846716 PMID:30339781 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Lif LIF, interleukin 6 family cytokine multiple interactions
increases expression		 EXP
ISO		 [Corticosterone co-treated with Isoflurophate] results in increased expression of LIF mRNA
[CORT protein co-treated with Isoflurophate] results in increased expression of LIF mRNA; [Corticosterone co-treated with Isoflurophate] results in increased expression of LIF mRNA; [Pyridostigmine Bromide co-treated with DEET] inhibits the reaction [[CORT protein co-treated with Isoflurophate] results in increased expression of LIF mRNA]; [Pyridostigmine Bromide co-treated with DEET] inhibits the reaction [Isoflurophate results in increased expression of LIF mRNA]		 CTD PMID:28500787 PMID:28782715 PMID:29846716 PMID:30339781 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Isoflurophate inhibits the reaction [PLG protein results in increased phosphorylation of MAPK1 protein] CTD PMID:17482686 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Isoflurophate inhibits the reaction [PLG protein results in increased phosphorylation of MAPK3 protein] CTD PMID:17482686 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 decreases activity ISO Isoflurophate results in decreased activity of NCEH1 protein CTD PMID:16978018 NCBI chr 2:110,074,985...110,135,592
Ensembl chr 2:110,074,957...110,135,588 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases degradation ISO Isoflurophate results in decreased degradation of NR3C1 protein CTD PMID:3545320 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Oprm1 opioid receptor, mu 1 affects response to substance ISO OPRM1 affects the susceptibility to Isoflurophate CTD PMID:15378609 PMID:15800401 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Osm oncostatin M multiple interactions
increases expression		 EXP
ISO		 [Corticosterone co-treated with Isoflurophate] results in increased expression of OSM mRNA
Isoflurophate results in increased expression of OSM mRNA
[Corticosterone co-treated with Isoflurophate] results in increased expression of OSM mRNA; [Pyridostigmine Bromide co-treated with DEET] inhibits the reaction [Isoflurophate results in increased expression of OSM mRNA]; [Pyridostigmine Bromide co-treated with DEET] promotes the reaction [CORT protein inhibits the reaction [Isoflurophate results in increased expression of OSM mRNA]]; CORT protein inhibits the reaction [Isoflurophate results in increased expression of OSM mRNA]		 CTD PMID:28500787 PMID:28782715 PMID:29846716 PMID:30339781 NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313 		JBrowse link
G Pepd peptidase D increases hydrolysis
decreases response to substance		 ISO PEPD protein results in increased hydrolysis of Isoflurophate
PEPD protein results in decreased susceptibility to Isoflurophate		 CTD PMID:20176006 PMID:22120822 PMID:22677456 PMID:22982776 NCBI chr 1:87,536,650...87,681,233
Ensembl chr 1:87,536,609...87,681,231 		JBrowse link
G Plg plasminogen multiple interactions ISO Isoflurophate inhibits the reaction [PLG protein results in increased phosphorylation of MAPK1 protein]; Isoflurophate inhibits the reaction [PLG protein results in increased phosphorylation of MAPK3 protein] CTD PMID:17482686 NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786 		JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 affects response to substance
decreases activity		 ISO
EXP		 PNPLA6 protein mutant form affects the susceptibility to Isoflurophate
Isoflurophate results in decreased activity of PNPLA6 protein		 CTD PMID:7713347 PMID:9268605 PMID:20382209 PMID:24395470 NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734 		JBrowse link
G Pon1 paraoxonase 1 increases hydrolysis
multiple interactions		 ISO PON1 protein results in increased hydrolysis of Isoflurophate
2-hydroxyquinoline inhibits the reaction [PON1 protein results in increased hydrolysis of Isoflurophate]		 CTD PMID:20176006 PMID:21382471 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression EXP Isoflurophate results in increased expression of PTGS2 mRNA CTD PMID:35500718 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rbfox3 RNA binding fox-1 homolog 3 decreases expression EXP Isoflurophate results in decreased expression of RBFOX3 protein CTD PMID:21513723 NCBI chr10:103,720,355...104,157,277
Ensembl chr10:103,720,636...104,156,935 		JBrowse link
G Rgn regucalcin increases hydrolysis ISO RGN protein results in increased hydrolysis of Isoflurophate CTD PMID:20176006 NCBI chr  X:1,619,030...1,634,456
Ensembl chr  X:1,619,032...1,634,450 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [Corticosterone co-treated with Isoflurophate] results in increased phosphorylation of STAT3 protein CTD PMID:28500787 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tf transferrin affects binding
increases expression
decreases expression		 ISO
EXP		 Isoflurophate binds to TRF protein
Isoflurophate binds to TF protein
Isoflurophate results in increased expression of TF protein
Isoflurophate results in decreased expression of TF protein		 CTD PMID:18930948 PMID:30389396 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
decreases expression		 EXP
ISO		 [Corticosterone co-treated with Isoflurophate] results in increased expression of TNF mRNA; AEOL 10150 inhibits the reaction [Isoflurophate results in increased expression of TNF protein]
Isoflurophate results in increased expression of TNF mRNA; Isoflurophate results in increased expression of TNF protein
Isoflurophate results in decreased expression of TNF mRNA
[Corticosterone co-treated with Isoflurophate] results in increased expression of TNF mRNA; CORT protein inhibits the reaction [Isoflurophate results in decreased expression of TNF mRNA]; Corticosterone promotes the reaction [Isoflurophate results in increased expression of TNF mRNA]		 CTD PMID:28500787 PMID:28782715 PMID:29272548 PMID:29846716 PMID:30339781 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions
increases expression		 EXP Isoflurophate promotes the reaction [XDH protein alternative form results in increased abundance of F2-Isoprostanes]; Isoflurophate promotes the reaction [XDH protein alternative form results in increased abundance of Reactive Oxygen Species]; Tubocurarine inhibits the reaction [Isoflurophate results in increased expression of XDH protein alternative form] CTD PMID:9789800 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        NMR chemical shift reference compound 18065
          phosphoric acid 13926
            phosphoric acid derivative 13835
              organic phosphate 13834
                alkyl phosphate 7980
                  dialkyl phosphate 7516
                    diisopropyl fluorophosphate 48
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      chalcogen 19563
                        oxygen atom 19535
                          oxygen molecular entity 19535
                            hydroxides 19341
                              oxoacid 18777
                                pnictogen oxoacid 14974
                                  phosphorus oxoacid 14577
                                    phosphoric acids 13926
                                      phosphoric acid 13926
                                        phosphoric acid derivative 13835
                                          phosphate 13834
                                            organic phosphate 13834
                                              alkyl phosphate 7980
                                                dialkyl phosphate 7516
                                                  diisopropyl fluorophosphate 48
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